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Conserved domains on  [gi|767922177|ref|XP_011531604|]
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cAMP-regulated phosphoprotein 21 isoform X1 [Homo sapiens]

Protein Classification

R3H_encore_like and SUZ domain-containing protein( domain architecture ID 12927641)

protein containing domains R3H_encore_like, SUZ, and PAT1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
163-224 8.40e-26

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


:

Pssm-ID: 100071  Cd Length: 63  Bit Score: 100.75  E-value: 8.40e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922177 163 DRMILLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 224
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
245-300 2.59e-13

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


:

Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 65.04  E-value: 2.59e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767922177  245 ESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS 300
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
608-795 6.37e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  608 PPSGPVYPSSLmPQPAQQPSYVIASTG-----QQLPTGGFSGSGPPISQQVLQPPPSPqgfvQQPPPAQMPVYYYPSGQY 682
Cdd:pfam09770 166 APKKAAAPAPA-PQPAAQPASLPAPSRkmmslEEVEAAMRAQAKKPAQQPAPAPAQPP----AAPPAQQAQQQQQFPPQI 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  683 PTSTTQQYRPMAPVQYNAQrsqqmpqaaqqaGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQS---------VM 753
Cdd:pfam09770 241 QQQQQPQQQPQQPQQHPGQ------------GHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVqptqilqnpNR 308
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 767922177  754 VSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPA 795
Cdd:pfam09770 309 LSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
PHA03247 super family cl33720
large tegument protein UL36; Provisional
428-695 1.49e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  428 PPLQSTPLVSGVAAGSPGCVPYPENGIGGQVAPSSTSYILLPLEAATGIPPGSillnphtgqpfVNPDGTPAIYNPPTSQ 507
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----------PARPARPPTTAGPPAP 2769
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  508 QPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQMAGPlvTQSVQGLQASSQSVQYPAVSFPPqhllPVSPTQhfpmrdd 587
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP--PAAVLAPAAALPPAASPAGPLPP----PTSAQP------- 2836
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  588 vatqfgqmtlsrqssgETPEPPSGPVyPSSLMPQPAQQPSYVIASTG--QQLPTGGFSGSGPPISQqVLQPPPSPQGFVQ 665
Cdd:PHA03247 2837 ----------------TAPPPPPGPP-PPSLPLGGSVAPGGDVRRRPpsRSPAAKPAAPARPPVRR-LARPAVSRSTESF 2898
                         250       260       270
                  ....*....|....*....|....*....|.
gi 767922177  666 -QPPPAQMPVYYYPSGQYPTSTTQQYRPMAP 695
Cdd:PHA03247 2899 aLPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
163-224 8.40e-26

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 100.75  E-value: 8.40e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922177 163 DRMILLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 224
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
147-224 4.43e-14

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 68.10  E-value: 4.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177   147 IDLHEFLINTLKNNSRDRMILLKMEQEIIDFIAdNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINKT 224
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
245-300 2.59e-13

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 65.04  E-value: 2.59e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767922177  245 ESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS 300
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
165-223 3.80e-12

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 61.74  E-value: 3.80e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767922177  165 MILLKMEQEIIDFIADNNNHYKkFPQMSSYQRMLVHRVAAYFGLDHNV--DQTGKSVIINK 223
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
608-795 6.37e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  608 PPSGPVYPSSLmPQPAQQPSYVIASTG-----QQLPTGGFSGSGPPISQQVLQPPPSPqgfvQQPPPAQMPVYYYPSGQY 682
Cdd:pfam09770 166 APKKAAAPAPA-PQPAAQPASLPAPSRkmmslEEVEAAMRAQAKKPAQQPAPAPAQPP----AAPPAQQAQQQQQFPPQI 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  683 PTSTTQQYRPMAPVQYNAQrsqqmpqaaqqaGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQS---------VM 753
Cdd:pfam09770 241 QQQQQPQQQPQQPQQHPGQ------------GHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVqptqilqnpNR 308
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 767922177  754 VSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPA 795
Cdd:pfam09770 309 LSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
PHA03247 PHA03247
large tegument protein UL36; Provisional
428-695 1.49e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  428 PPLQSTPLVSGVAAGSPGCVPYPENGIGGQVAPSSTSYILLPLEAATGIPPGSillnphtgqpfVNPDGTPAIYNPPTSQ 507
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----------PARPARPPTTAGPPAP 2769
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  508 QPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQMAGPlvTQSVQGLQASSQSVQYPAVSFPPqhllPVSPTQhfpmrdd 587
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP--PAAVLAPAAALPPAASPAGPLPP----PTSAQP------- 2836
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  588 vatqfgqmtlsrqssgETPEPPSGPVyPSSLMPQPAQQPSYVIASTG--QQLPTGGFSGSGPPISQqVLQPPPSPQGFVQ 665
Cdd:PHA03247 2837 ----------------TAPPPPPGPP-PPSLPLGGSVAPGGDVRRRPpsRSPAAKPAAPARPPVRR-LARPAVSRSTESF 2898
                         250       260       270
                  ....*....|....*....|....*....|.
gi 767922177  666 -QPPPAQMPVYYYPSGQYPTSTTQQYRPMAP 695
Cdd:PHA03247 2899 aLPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929
PRK10263 PRK10263
DNA translocase FtsK; Provisional
609-801 3.49e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  609 PSGPVYPSSLMPQPAQQPSYVIASTgQQLPtggfsgsGPPISQQVLQPppSPQGFVQQPPPAQmpvyyyPSGQYPTSTTQ 688
Cdd:PRK10263  336 PVEPVTQTPPVASVDVPPAQPTVAW-QPVP-------GPQTGEPVIAP--APEGYPQQSQYAQ------PAVQYNEPLQQ 399
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  689 QYRPMAPVQYNAQRSQQMPQAAQQAGYQPVLSGQQGFQgligVQQPPQSQNVINNQQGTPVQSvMVSYPTMSSYQVPMTQ 768
Cdd:PRK10263  400 PVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA----PEQPVAGNAWQAEEQQSTFAP-QSTYQTEQTYQQPAAQ 474
                         170       180       190
                  ....*....|....*....|....*....|...
gi 767922177  769 GSQGLPQQSYQQPIMLPNQAGQGSLPATGMPVY 801
Cdd:PRK10263  475 EPLYQQPQPVEQQPVVEPEPVVEETKPARPPLY 507
SP1-4_arthropods_N cd22553
N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; ...
578-821 4.56e-03

N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in the chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. One SP is clade SP1-4, which is expressed ubiquitously throughout development. SP1-4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. This model represents the N-terminal domain of SP1-4 from arthropods.


Pssm-ID: 411778 [Multi-domain]  Cd Length: 384  Bit Score: 40.39  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177 578 PTQHFPMRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQ--PAQQPsyVIASTGQ------QLPTGGFSGSGPPI 649
Cdd:cd22553  113 ANQQTLIRPNTVQGQANASNVLQNIAQIASGGNAVQLPLNNMTQtiPVQVP--VSTANGQtvyqtiQVPIQAIQSGNAGG 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177 650 SQQVLQPPPSPQgfVQQPPPAQMPVYYYPSGQ-----YPTSTTQQYRPMAPVQYNaQRSQQMPQAAQQAGYQPVLSGQQG 724
Cdd:cd22553  191 GNQALQAQVIPQ--LAQAAQLQPQQLAQVSSQgyiqqIPANASQQQPQMVQQGPN-QSGQIIGQVASASSIQAAAIPLTV 267
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177 725 FQGLIGvqqppqSQNVINNQQGTPVQSV--------MVSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPAT 796
Cdd:cd22553  268 YTGALA------GQNGSNQQQVGQIVTSpiqgmtqgLTAPASSSIPTVVQQQAIQGNPLPPGTQIIAAGQQLQQDPNDPT 341
                        250       260
                 ....*....|....*....|....*
gi 767922177 797 GMPVYCNVTPPTPQnNLRLIGPHCP 821
Cdd:cd22553  342 KWQVVADGTPGSKK-RLRRVACTCP 365
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
163-224 8.40e-26

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 100.75  E-value: 8.40e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767922177 163 DRMILLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG-KSVIINKT 224
Cdd:cd02642    1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
147-224 4.43e-14

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 68.10  E-value: 4.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177   147 IDLHEFLINTLKNNSRDRMILLKMEQEIIDFIAdNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINKT 224
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGpkRRVVISKK 79
SUZ pfam12752
SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched ...
245-300 2.59e-13

SUZ domain; The SUZ domain is a conserved RNA-binding domain found in eukaryotes and enriched in positively charged amino acids. It was first characterized in the C.elegans protein Szy-20 where it has been shown to bind RNA and allow their localization to the centrosome. Warning- the domain has a compositionally biased character.


Pssm-ID: 463689 [Multi-domain]  Cd Length: 56  Bit Score: 65.04  E-value: 2.59e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767922177  245 ESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS 300
Cdd:pfam12752   1 PPPKMKILRRPSSGSSSSSSAGSSGASSSSGSDSKTLEEREAEYAEARARIFGSSE 56
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
167-223 1.89e-12

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 62.63  E-value: 1.89e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767922177 167 LLKMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTG--KSVIINK 223
Cdd:cd02325    1 REEREEELEAFAKDAAGKSLELPPMNSYERKLIHDLAEYYGLKSESEGEGpnRRVVITK 59
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
165-223 3.80e-12

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 61.74  E-value: 3.80e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767922177  165 MILLKMEQEIIDFIADNNNHYKkFPQMSSYQRMLVHRVAAYFGLDHNV--DQTGKSVIINK 223
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
608-795 6.37e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  608 PPSGPVYPSSLmPQPAQQPSYVIASTG-----QQLPTGGFSGSGPPISQQVLQPPPSPqgfvQQPPPAQMPVYYYPSGQY 682
Cdd:pfam09770 166 APKKAAAPAPA-PQPAAQPASLPAPSRkmmslEEVEAAMRAQAKKPAQQPAPAPAQPP----AAPPAQQAQQQQQFPPQI 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  683 PTSTTQQYRPMAPVQYNAQrsqqmpqaaqqaGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQS---------VM 753
Cdd:pfam09770 241 QQQQQPQQQPQQPQQHPGQ------------GHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVqptqilqnpNR 308
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 767922177  754 VSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPA 795
Cdd:pfam09770 309 LSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ 350
PHA03247 PHA03247
large tegument protein UL36; Provisional
428-695 1.49e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  428 PPLQSTPLVSGVAAGSPGCVPYPENGIGGQVAPSSTSYILLPLEAATGIPPGSillnphtgqpfVNPDGTPAIYNPPTSQ 507
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----------PARPARPPTTAGPPAP 2769
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  508 QPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQMAGPlvTQSVQGLQASSQSVQYPAVSFPPqhllPVSPTQhfpmrdd 587
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP--PAAVLAPAAALPPAASPAGPLPP----PTSAQP------- 2836
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  588 vatqfgqmtlsrqssgETPEPPSGPVyPSSLMPQPAQQPSYVIASTG--QQLPTGGFSGSGPPISQqVLQPPPSPQGFVQ 665
Cdd:PHA03247 2837 ----------------TAPPPPPGPP-PPSLPLGGSVAPGGDVRRRPpsRSPAAKPAAPARPPVRR-LARPAVSRSTESF 2898
                         250       260       270
                  ....*....|....*....|....*....|.
gi 767922177  666 -QPPPAQMPVYYYPSGQYPTSTTQQYRPMAP 695
Cdd:PHA03247 2899 aLPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929
PHA03247 PHA03247
large tegument protein UL36; Provisional
425-844 1.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  425 RTHPPLQSTPLVSGVAAGS----PGCVPYPENGIG---------GQVAPSStsyilLPLEAATGIPPgsillnPHTGQPF 491
Cdd:PHA03247 2566 RSVPPPRPAPRPSEPAVTSrarrPDAPPQSARPRApvddrgdprGPAPPSP-----LPPDTHAPDPP------PPSPSPA 2634
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  492 VNPDGTPAIYNPPTSQQPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQ-PQMAGPLVTQSVQGL------QASSQSVQYP 564
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRpRRRAARPTVGSLTSLadppppPPTPEPAPHA 2714
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  565 AVSFPPQHLLPVSPTQHFPMR----------DDVATQFGQMTLSRQSSGETPEPPSGPVYPSS----------------- 617
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALpaapappavpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAgpprrltrpavaslses 2794
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  618 -----LMPQPAQQPSYVIASTGQQLPTGGFSGSGPPISQQVLQPPPSPQGFVqqPPPAQMPVYYYPSGQY---PTSTTQQ 689
Cdd:PHA03247 2795 reslpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP--PPSLPLGGSVAPGGDVrrrPPSRSPA 2872
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  690 YRPMAPVQYNAQRSQqmpqaaqqagyQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQSVMVSYPTMSsyqvPMTQG 769
Cdd:PHA03247 2873 AKPAAPARPPVRRLA-----------RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP----PPPPP 2937
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767922177  770 SQGLPQQSYQQPIMLPNQAGQGSLPATGMPVYCNVTPPTpqnnlRLIGPHCPSSTVPVMSASCRTNCASMSNAGW 844
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR-----FRVPQPAPSREAPASSTPPLTGHSLSRVSSW 3007
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
507-845 2.13e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  507 QQPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQMAGPLVTQSVQGLQASSQSVQYPAVSFPPQHLLPVSPTQHFPMRD 586
Cdd:pfam03154 164 QQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLP 243
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  587 DVATQFGQMTLSRQSSGETPEPPSGPVY--PSSLMPQPAQ------------QPSYVIASTGQ-QLPTGGFSGSGPPISQ 651
Cdd:pfam03154 244 SPHPPLQPMTQPPPPSQVSPQPLPQPSLhgQMPPMPHSLQtgpshmqhpvppQPFPLTPQSSQsQVPPGPSPAAPGQSQQ 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  652 QVLQPPPSPQGFVQQP------PPAQMPVyyyPSGQYPTSTtqqyrPMAPVQyNAQRSQqmpqaaqqagYQPVLSGQQGF 725
Cdd:pfam03154 324 RIHTPPSQSQLQSQQPpreqplPPAPLSM---PHIKPPPTT-----PIPQLP-NPQSHK----------HPPHLSGPSPF 384
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  726 QGLIGVQQPPQSQnvinnqqgtPVQSVMVSYPTmSSYQVP---MTQgSQGLPQQSYQQPIMLPNQ---AGQGSLPATGMP 799
Cdd:pfam03154 385 QMNSNLPPPPALK---------PLSSLSTHHPP-SAHPPPlqlMPQ-SQQLPPPPAQPPVLTQSQslpPPAASHPPTSGL 453
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 767922177  800 VYCNVTPPTPQNnlrligPHCPSSTVPVMSASCRTNCASMSNAGWQ 845
Cdd:pfam03154 454 HQVPSQSPFPQH------PFVPGGPPPITPPSGPPTSTSSAMPGIQ 493
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
485-809 2.66e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  485 PHTGQPFVNPDGTPAIYNPPTSQQPLRSAMvgQSQQQPPQQQPSPQPQQQVQPPQPQMAGPLVTQSVQGLQASSQSVQYP 564
Cdd:pfam03154 199 PTPSAPSVPPQGSPATSQPPNQTQSTAAPH--TLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMP 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  565 AVSFP----PQHLLPVSPTQHFPMRDDVATQFGQMTLSRQSSGETPEPPSGPvyPSSLMPQPAQQPSYviastgQQLPTG 640
Cdd:pfam03154 277 PMPHSlqtgPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTP--PSQSQLQSQQPPRE------QPLPPA 348
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  641 gfsgsgpPISQQVLQPPPS--------PQG-----FVQQPPPAQMPVYY-YPSGQYPTSTTQQYRPMAPVQYNAQRSQQM 706
Cdd:pfam03154 349 -------PLSMPHIKPPPTtpipqlpnPQShkhppHLSGPSPFQMNSNLpPPPALKPLSSLSTHHPPSAHPPPLQLMPQS 421
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  707 PQAAQQAGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQSVMVSYPT-MSSYQVPMTQGSQGLPqqSYQQPIMLP 785
Cdd:pfam03154 422 QQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPpITPPSGPPTSTSSAMP--GIQPPSSAS 499
                         330       340
                  ....*....|....*....|....
gi 767922177  786 nqagqgslPATGMPVYCNVTPPTP 809
Cdd:pfam03154 500 --------VSSSGPVPAAVSCPLP 515
R3H_unknown_2 cd06006
R3H domain of a group of fungal proteins with unknown function. The name of the R3H domain ...
169-209 2.88e-03

R3H domain of a group of fungal proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100076  Cd Length: 59  Bit Score: 36.58  E-value: 2.88e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767922177 169 KMEQEIIDFIADNNNHYKKFPQMSSYQRMLVHRVAAYFGLD 209
Cdd:cd06006    3 QIESTLRKFINDKSKRSLRFPPMRSPQRAFIHELAKDYGLY 43
PRK10263 PRK10263
DNA translocase FtsK; Provisional
609-801 3.49e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  609 PSGPVYPSSLMPQPAQQPSYVIASTgQQLPtggfsgsGPPISQQVLQPppSPQGFVQQPPPAQmpvyyyPSGQYPTSTTQ 688
Cdd:PRK10263  336 PVEPVTQTPPVASVDVPPAQPTVAW-QPVP-------GPQTGEPVIAP--APEGYPQQSQYAQ------PAVQYNEPLQQ 399
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177  689 QYRPMAPVQYNAQRSQQMPQAAQQAGYQPVLSGQQGFQgligVQQPPQSQNVINNQQGTPVQSvMVSYPTMSSYQVPMTQ 768
Cdd:PRK10263  400 PVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPA----PEQPVAGNAWQAEEQQSTFAP-QSTYQTEQTYQQPAAQ 474
                         170       180       190
                  ....*....|....*....|....*....|...
gi 767922177  769 GSQGLPQQSYQQPIMLPNQAGQGSLPATGMPVY 801
Cdd:PRK10263  475 EPLYQQPQPVEQQPVVEPEPVVEETKPARPPLY 507
SP1-4_arthropods_N cd22553
N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; ...
578-821 4.56e-03

N-terminal domain of transcription factor Specificity Protein (SP) 1-4 from arthropods; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. There are many SPs in vertebrates (9 SPs in humans and mice, 7 SPs in the chicken, and 11 SPs in teleost fish), but arthropods only have 3 SPs. One SP is clade SP1-4, which is expressed ubiquitously throughout development. SP1-4 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. This model represents the N-terminal domain of SP1-4 from arthropods.


Pssm-ID: 411778 [Multi-domain]  Cd Length: 384  Bit Score: 40.39  E-value: 4.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177 578 PTQHFPMRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQ--PAQQPsyVIASTGQ------QLPTGGFSGSGPPI 649
Cdd:cd22553  113 ANQQTLIRPNTVQGQANASNVLQNIAQIASGGNAVQLPLNNMTQtiPVQVP--VSTANGQtvyqtiQVPIQAIQSGNAGG 190
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177 650 SQQVLQPPPSPQgfVQQPPPAQMPVYYYPSGQ-----YPTSTTQQYRPMAPVQYNaQRSQQMPQAAQQAGYQPVLSGQQG 724
Cdd:cd22553  191 GNQALQAQVIPQ--LAQAAQLQPQQLAQVSSQgyiqqIPANASQQQPQMVQQGPN-QSGQIIGQVASASSIQAAAIPLTV 267
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177 725 FQGLIGvqqppqSQNVINNQQGTPVQSV--------MVSYPTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPAT 796
Cdd:cd22553  268 YTGALA------GQNGSNQQQVGQIVTSpiqgmtqgLTAPASSSIPTVVQQQAIQGNPLPPGTQIIAAGQQLQQDPNDPT 341
                        250       260
                 ....*....|....*....|....*
gi 767922177 797 GMPVYCNVTPPTPQnNLRLIGPHCP 821
Cdd:cd22553  342 KWQVVADGTPGSKK-RLRRVACTCP 365
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
601-697 5.68e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.14  E-value: 5.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922177 601 SSGETPEPPSGP---VYPSSLMPQPAQQPSYVIASTGQQLPTGgfSGSGPPISQQVLQPPPS-PQGFVQQPPPAQMPVYY 676
Cdd:PRK14971 364 QKGDDASGGRGPkqhIKPVFTQPAAAPQPSAAAAASPSPSQSS--AAAQPSAPQSATQPAGTpPTVSVDPPAAVPVNPPS 441
                         90       100
                 ....*....|....*....|.
gi 767922177 677 YPSGQYPTSTTQQYRPMAPVQ 697
Cdd:PRK14971 442 TAPQAVRPAQFKEEKKIPVSK 462
R3H_Smubp-2_like cd02641
R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and ...
174-221 6.51e-03

R3H domain of Smubp-2_like proteins. Smubp-2_like proteins also contain a helicase_like and an AN1-like Zinc finger domain and have been shown to bind single-stranded DNA. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA.


Pssm-ID: 100070  Cd Length: 60  Bit Score: 35.79  E-value: 6.51e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 767922177 174 IIDFIADNNNHYKKFP-QMSSYQRMLVHRVAAYFGLDHNVDQTGKSVII 221
Cdd:cd02641    8 VKAFMKDPKATELEFPpTLSSHDRLLVHELAEELGLRHESTGEGSDRVI 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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