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Conserved domains on  [gi|767922476|ref|XP_011531721|]
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coiled-coil domain-containing protein 13 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 4-234 9.78e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 9.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476     4 LRNQIQSVKQELRMAQKVLAR-EVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGT--------- 73
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTElEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELraeltllne 817

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    74 --ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMG 151
Cdd:TIGR02168  818 eaANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE 897

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   152 TLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMV----AEREAKVRQL 227
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIeddeEEARRRLKRL 977


                   ....*..
gi 767922476   228 EMEIGQL 234
Cdd:TIGR02168  978 ENKIKEL 984
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 4-234 9.78e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 9.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476     4 LRNQIQSVKQELRMAQKVLAR-EVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGT--------- 73
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTElEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELraeltllne 817

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    74 --ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMG 151
Cdd:TIGR02168  818 eaANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE 897

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   152 TLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMV----AEREAKVRQL 227
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIeddeEEARRRLKRL 977


                   ....*..
gi 767922476   228 EMEIGQL 234
Cdd:TIGR02168  978 ENKIKEL 984
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 35-235 3.08e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 3.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  35 LLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLR-IRSLERE---KQEGLEK 110
Cdd:COG4942    8 ALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARrIRALEQElaaLEAELAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476 111 LASERDVLQRELEELKKKFE---------GMRSRNKLL--SSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILG 179
Cdd:COG4942   88 LEKEIAELRAELEAQKEELAellralyrlGRQPPLALLlsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767922476 180 SLSLQEEKTRVSQHHLDQQ---LNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLN 235
Cdd:COG4942  168 ELEAERAELEALLAELEEEraaLEALKAERQKLLARLEKELAELAAELAELQQEAEELE 226
PRK12704 PRK12704
phosphodiesterase; Provisional
 60-223 4.64e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.92  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  60 EKQLGQARSQSAGT---ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRElEELKKKFEGMRSR 135
Cdd:PRK12704  30 EAKIKEAEEEAKRIleeAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKlEKRLLQKE-ENLDRKLELLEKR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476 136 NKLLSSEMKTLKSQMGTLVEKgrhDDELIDALMDQLKQLQEILGsLSLQEEKTRvsqhhLDQQLNSEAQrsnslvAQLQA 215
Cdd:PRK12704 109 EEELEKKEKELEQKQQELEKK---EEELEELIEEQLQELERISG-LTAEEAKEI-----LLEKVEEEAR------HEAAV 173

                        170
                 ....*....|
gi 767922476 216 MV--AEREAK 223
Cdd:PRK12704 174 LIkeIEEEAK 183
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 3-243 6.50e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 39.33  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476     3 DLRNQIQSVKQELRmAQKVLAREVGEDINVQ--QLLSSPGTWRGRAQQILVLQSKVQELE---------------KQLGQ 65
Cdd:pfam15921  142 DLRNQLQNTVHELE-AAKCLKEDMLEDSNTQieQLRKMMLSHEGVLQEIRSILVDFEEASgkkiyehdsmstmhfRSLGS 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    66 ARSQSAGTASDELS-----VYPDPRKLSA-QEKNLLRIRSLEREKQEGLEKLASERDVlqrELEELKKKFEGMRsrnkll 139
Cdd:pfam15921  221 AISKILRELDTEISylkgrIFPVEDQLEAlKSESQNKIELLLQQHQDRIEQLISEHEV---EITGLTEKASSAR------ 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   140 sSEMKTLKSQMGTLVEKGRHDDELidaLMDQLKQLQEILGSL--SLQEEKTRVSQ--HHLDQQL---NSE---------- 202
Cdd:pfam15921  292 -SQANSIQSQLEIIQEQARNQNSM---YMRQLSDLESTVSQLrsELREAKRMYEDkiEELEKQLvlaNSEltearterdq 367

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 767922476   203 -AQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKG 243
Cdd:pfam15921  368 fSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG 409
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 4-234 9.78e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.14  E-value: 9.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476     4 LRNQIQSVKQELRMAQKVLAR-EVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGT--------- 73
Cdd:TIGR02168  738 LEAEVEQLEERIAQLSKELTElEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELraeltllne 817

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    74 --ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMG 151
Cdd:TIGR02168  818 eaANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELE 897

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   152 TLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMV----AEREAKVRQL 227
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIeddeEEARRRLKRL 977


                   ....*..
gi 767922476   228 EMEIGQL 234
Cdd:TIGR02168  978 ENKIKEL 984
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 35-235 3.08e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 3.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  35 LLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLR-IRSLERE---KQEGLEK 110
Cdd:COG4942    8 ALLLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARrIRALEQElaaLEAELAE 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476 111 LASERDVLQRELEELKKKFE---------GMRSRNKLL--SSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILG 179
Cdd:COG4942   88 LEKEIAELRAELEAQKEELAellralyrlGRQPPLALLlsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRA 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767922476 180 SLSLQEEKTRVSQHHLDQQ---LNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLN 235
Cdd:COG4942  168 ELEAERAELEALLAELEEEraaLEALKAERQKLLARLEKELAELAAELAELQQEAEELE 226
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 47-230 2.47e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.97  E-value: 2.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    47 QQILVLQSKVQELEKQLGQARSQSAGTASDELSVYPDPRKLSAQEKNLLriRSLEREKQEgLEKLASERDVLQRELEELK 126
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALR--KDLARLEAE-VEQLEERIAQLSKELTELE 760

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   127 KKFEGMRSRNKLLSSEMKTLKSQMGTLvekgrhdDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRS 206
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAEIEEL-------EAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRI 833

                          170       180
                   ....*....|....*....|....
gi 767922476   207 NSLVAQLQamVAEREAKVRQLEME 230
Cdd:TIGR02168  834 AATERRLE--DLEEQIEELSEDIE 855
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 85-234 2.48e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  85 RKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELI 164
Cdd:COG1196  232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476 165 DALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQL 234
Cdd:COG1196  312 RELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEEL 381
PRK12704 PRK12704
phosphodiesterase; Provisional
 60-223 4.64e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 45.92  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  60 EKQLGQARSQSAGT---ASDELSVYPDPRKLSAQEKNLLRIRSLEREKQEGLEKLAS-ERDVLQRElEELKKKFEGMRSR 135
Cdd:PRK12704  30 EAKIKEAEEEAKRIleeAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKlEKRLLQKE-ENLDRKLELLEKR 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476 136 NKLLSSEMKTLKSQMGTLVEKgrhDDELIDALMDQLKQLQEILGsLSLQEEKTRvsqhhLDQQLNSEAQrsnslvAQLQA 215
Cdd:PRK12704 109 EEELEKKEKELEQKQQELEKK---EEELEELIEEQLQELERISG-LTAEEAKEI-----LLEKVEEEAR------HEAAV 173

                        170
                 ....*....|
gi 767922476 216 MV--AEREAK 223
Cdd:PRK12704 174 LIkeIEEEAK 183
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
46-228 5.33e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   46 AQQILVLQSKVQELEKQLGQARSQSAgTASDELSVYPDPRKLSAQEKNLL----RIRSLEREKQEgLEKLASERDVLQRE 121
Cdd:COG4913   616 EAELAELEEELAEAEERLEALEAELD-ALQERREALQRLAEYSWDEIDVAsaerEIAELEAELER-LDASSDDLAALEEQ 693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  122 LEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVekgrhddELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDqqlNS 201
Cdd:COG4913   694 LEELEAELEELEEELDELKGEIGRLEKELEQAE-------EELDELQDRLEAAEDLARLELRALLEERFAAALGD---AV 763

                         170       180
                  ....*....|....*....|....*..
gi 767922476  202 EAQRSNSLVAQLQAMVAEREAKVRQLE 228
Cdd:COG4913   764 ERELRENLEERIDALRARLNRAEEELE 790
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 67-235 1.03e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 45.33  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   67 RSQSAGTASDELSVYPDPRKLSAQEKnllrirSLEREKQEgLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTL 146
Cdd:COG3096   490 RSQAWQTARELLRRYRSQQALAQRLQ------QLRAQLAE-LEQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAEL 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  147 KSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQ---HHLDQQLNSEAQRSNSLVAQLQAMV-AEREA 222
Cdd:COG3096   563 EAQLEELEEQAAEAVEQRSELRQQLEQLRARIKELAARAPAWLAAQdalERLREQSGEALADSQEVTAAMQQLLeREREA 642

                         170       180
                  ....*....|....*....|..
gi 767922476  223 KV---------RQLEMEIGQLN 235
Cdd:COG3096   643 TVerdelaarkQALESQIERLS 664
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 85-228 1.11e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  85 RKLSAQEKNLLRIRSLEREKQEGLEKLASERDV------LQRELEELK-----KKFEGMRSRNKLLSSEMKTLKSQMGTL 153
Cdd:COG1196  179 RKLEATEENLERLEDILGELERQLEPLERQAEKaeryreLKEELKELEaelllLKLRELEAELEELEAELEELEAELEEL 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767922476 154 VEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 228
Cdd:COG1196  259 EAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELE 333
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 86-386 1.25e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    86 KLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELID 165
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   166 ALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAER---EAKVRQLEMEIGQLNvhylrnk 242
Cdd:TIGR02168  313 NLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeelESRLEELEEQLETLR------- 385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   243 gvgegssgREVSPAYTQFLEdpgLTKSPASAGDHVGRLGSSRSVTslgHTLVESALTRPslpsphrtsprfsDSPEQKGW 322
Cdd:TIGR02168  386 --------SKVAQLELQIAS---LNNEIERLEARLERLEDRRERL---QQEIEELLKKL-------------EEAELKEL 438

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767922476   323 QAQVSEIKALWQAAEVERDRLTEFVTVLQKRVEESNSKLLESERKLQEERHRTVVLEQHLEKIR 386
Cdd:TIGR02168  439 QAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLE 502
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 2-226 5.58e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.06  E-value: 5.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   2 SDLRNQIQSVKQELRMAQKVLAREVGEDINVQQLLSSpgtwrgRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVY 81
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA------LERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  82 pdpRKLSAQEKNL-LRIRSLER-EKQEGLEKLASERDVLQ--RELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKG 157
Cdd:COG4942   97 ---AELEAQKEELaELLRALYRlGRQPPLALLLSPEDFLDavRRLQYLKYLAPARREQAEELRADLAELAALRAELEAER 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922476 158 RHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQ 226
Cdd:COG4942  174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
85-228 1.04e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.97  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  85 RKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKK---KFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDD 161
Cdd:PRK03918 193 ELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEElkeEIEELEKELESLEGSKRKLEEKIRELEERIEELK 272

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922476 162 ELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLD--QQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 228
Cdd:PRK03918 273 KEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDelREIEKRLSRLEEEINGIEERIKELEEKEERLE 341
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 119-392 1.15e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   119 QRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQ 198
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKE 755

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   199 LNSEAQRSNSL---VAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKgvgegSSGREVSPAYTQfLEDPGLTKSPASAGD 275
Cdd:TIGR02168  756 LTELEAEIEELeerLEEAEEELAEAEAEIEELEAQIEQLKEELKALR-----EALDELRAELTL-LNEEAANLRERLESL 829

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   276 HVGRLGSSRSVTSLGHTLVESALTRPSLpsphrtsprfsdSPEQKGWQAQVSEIKALWQAAEVERDRLTEFVTVLQKRVE 355
Cdd:TIGR02168  830 ERRIAATERRLEDLEEQIEELSEDIESL------------AAEIEELEELIEELESELEALLNERASLEEALALLRSELE 897

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 767922476   356 ESNSKLLESERKLQEERHRTVVLEQHLEKIRLEPGKA 392
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGL 934
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 3-230 1.31e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   3 DLRNQIQSVKQELRMAQKVLAREVGEdinvqqllsspgtWRGRAQQILVLQSKVQELEKQLGQARSQSAGTASDELSVYP 82
Cdd:COG1196  236 ELEAELEELEAELEELEAELEELEAE-------------LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQ 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  83 DPRKLSAQEKNLL-RIRSLEREKQEGLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDD 161
Cdd:COG1196  303 DIARLEERRRELEeRLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767922476 162 ELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEME 230
Cdd:COG1196  383 ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1-219 3.73e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.90  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    1 MSDLRNQIQSVKQELRMAQKvlAREVGEDINVQQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQARSQSAgtasdelsv 80
Cdd:COG4913   244 LEDAREQIELLEPIRELAER--YAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEAELE--------- 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   81 ypdprKLSAQEKNLL-RIRSLEREKQE----GLEKLASERDVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVE 155
Cdd:COG4913   313 -----RLEARLDALReELDELEAQIRGnggdRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRA 387

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767922476  156 KGRhddELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAE 219
Cdd:COG4913   388 EAA---ALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDA 448
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 85-228 3.86e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 3.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    85 RKLSAQEKNLLRIRSLEREKQEGLEKLASER---------------------------------------DVLQRELEEL 125
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRRERekaeryqallkekreyegyellkekealerqkeaierqlASLEEELEKL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   126 KKKFEGMRSR---------------NKLLSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQEEKTRV 190
Cdd:TIGR02169  257 TEEISELEKRleeieqlleelnkkiKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLA 336

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 767922476   191 SQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 228
Cdd:TIGR02169  337 EIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELE 374
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 3-243 6.50e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 39.33  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476     3 DLRNQIQSVKQELRmAQKVLAREVGEDINVQ--QLLSSPGTWRGRAQQILVLQSKVQELE---------------KQLGQ 65
Cdd:pfam15921  142 DLRNQLQNTVHELE-AAKCLKEDMLEDSNTQieQLRKMMLSHEGVLQEIRSILVDFEEASgkkiyehdsmstmhfRSLGS 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476    66 ARSQSAGTASDELS-----VYPDPRKLSA-QEKNLLRIRSLEREKQEGLEKLASERDVlqrELEELKKKFEGMRsrnkll 139
Cdd:pfam15921  221 AISKILRELDTEISylkgrIFPVEDQLEAlKSESQNKIELLLQQHQDRIEQLISEHEV---EITGLTEKASSAR------ 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   140 sSEMKTLKSQMGTLVEKGRHDDELidaLMDQLKQLQEILGSL--SLQEEKTRVSQ--HHLDQQL---NSE---------- 202
Cdd:pfam15921  292 -SQANSIQSQLEIIQEQARNQNSM---YMRQLSDLESTVSQLrsELREAKRMYEDkiEELEKQLvlaNSEltearterdq 367

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 767922476   203 -AQRSNSLVAQLQAMVAEREAKVRQLEMEIGQLNVHYLRNKG 243
Cdd:pfam15921  368 fSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG 409
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
85-234 7.43e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.98  E-value: 7.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  85 RKLSAQEKNLLRIRSLEREKQEGLEKLASERDVLQRELEELKK--KFEGMRSRNKLLSSEMKTLKSQMGTLVEKGRHDDE 162
Cdd:COG4717   81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKllQLLPLYQELEALEAELAELPERLEELEERLEELRE 160

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767922476 163 LIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLEMEIGQL 234
Cdd:COG4717  161 LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQL 232
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1-228 7.90e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 7.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   1 MSDLRNQIQSVKQELRMAQKvlAREVGEDINVQQLlsspgtwRGRAQQILVLQSKVQELEKQLGQARSQSAgtasdelsv 80
Cdd:COG1196  195 LGELERQLEPLERQAEKAER--YRELKEELKELEA-------ELLLLKLRELEAELEELEAELEELEAELE--------- 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  81 ypdprKLSAQEKNLLRIRSLEREKQEGLEKLASER----DVLQRELEELKKKFEGMRSRNKLLSSEMKTLKSQMGTLVEK 156
Cdd:COG1196  257 -----ELEAELAELEAELEELRLELEELELELEEAqaeeYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEE 331

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767922476 157 GRHDDELIDALMDQLKQLQEILGSLSLQEEKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMVAEREAKVRQLE 228
Cdd:COG1196  332 LEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLE 403
mukB PRK04863
chromosome partition protein MukB;
33-220 9.18e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 38.78  E-value: 9.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476   33 QQLLSSPGTWRGRAQQILVLQSKVQELEKQLGQarSQSAGTASDELSvypdpRKLSAQEKNLLRIRSLEREKQEGLEKLA 112
Cdd:PRK04863  499 RELLRRLREQRHLAEQLQQLRMRLSELEQRLRQ--QQRAERLLAEFC-----KRLGKNLDDEDELEQLQEELEARLESLS 571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922476  113 SE-------RDVLQRELEELKKKFEGMRSRnkllSSEMKTLKSQMGTLVEKGRHDDELIDALMDQLKQLQEILGSLSLQE 185
Cdd:PRK04863  572 ESvsearerRMALRQQLEQLQARIQRLAAR----APAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVER 647

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 767922476  186 EKTRVSQHHLDQQLNSEAQRSNSLVAQLQAMvAER 220
Cdd:PRK04863  648 DELAARKQALDEEIERLSQPGGSEDPRLNAL-AER 681
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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