NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767922627|ref|XP_011531780|]
View 

5-aminolevulinate synthase, non-specific, mitochondrial isoform X2 [Homo sapiens]

Protein Classification

Preseq_ALAS and KBL_like domain-containing protein( domain architecture ID 11181659)

Preseq_ALAS and KBL_like domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 214-564 0e+00

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member TIGR01821:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 402  Bit Score: 548.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  214 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 293
Cdd:TIGR01821   1 MDYDQFFNKEIDKLHLEGRYRVFADLERQAGEFPFAQWHRPD--GAKDVTVWCSNDYLGMGQHPEVLQAMHETLDKYGAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  294 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 373
Cdd:TIGR01821  79 AGGTRNISGTNIPHVELEAELADLHGKESALVFTSGYVANDATLATLAKIIPGCVIFSDELNHASMIEGIRHSGAEKFIF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  374 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 406
Cdd:TIGR01821 159 RHNDVAHLEKLLQSVDPNRPKIIAFESVYSMDGdiapieeicdladkygaltyldevhavglygprgggiaerdglmhri 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  407 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEgrVLRRQHQRNVKLMRQMLM 478
Cdd:TIGR01821 239 diiegtlaKAFGVVGGYIAASRKLIDAIRSYAPGFIFTTSLPPAIAAGATASIRHLKESQ--DLRRAHQENVKRLKNLLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  479 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 558
Cdd:TIGR01821 317 ALGIPVIPNPSHIVPVIIGDAALCKKVSDLLLNKHGIYVQPINYPTVPRGTERLRITPTPAHTDKMIDDLVEALLLVWDR 396


                  ....*.
gi 767922627  559 VGLELK 564
Cdd:TIGR01821 397 LGLPLS 402
Preseq_ALAS pfam09029
5-aminolevulinate synthase presequence; The N terminal presequence domain found in ...
 19-154 1.16e-54

5-aminolevulinate synthase presequence; The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.


:

Pssm-ID: 462658  Cd Length: 114  Bit Score: 181.15  E-value: 1.16e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627   19 ESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMevgakpaPRALSTAAVHYQQIKE-TPPASEKDKTAKAkvqqtpd 97
Cdd:pfam09029   1 ASVLRRCPFLSRVPQAFLQKARKSLLSYAQRCPVMM-------TRALSTSSANLQGEKEeTPVAGPTAKQAKA------- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767922627   98 gsqqspdgtqLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEM 154
Cdd:pfam09029  67 ----------LPLGHPSPQAGQSVASKCPFLAAEMGQKNSNVVRKASPEVQEDVQEV 113
 
Name Accession Description Interval E-value
5aminolev_synth TIGR01821
5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an ...
 214-564 0e+00

5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an enzyme for one of two routes to the heme precursor 5-aminolevulinate. The protein is a pyridoxal phosphate-dependent enzyme related to 2-amino-3-ketobutyrate CoA tranferase and 8-amino-7-oxononanoate synthase. This enzyme appears restricted to the alpha Proteobacteria and mitochondrial derivatives. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273820 [Multi-domain]  Cd Length: 402  Bit Score: 548.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  214 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 293
Cdd:TIGR01821   1 MDYDQFFNKEIDKLHLEGRYRVFADLERQAGEFPFAQWHRPD--GAKDVTVWCSNDYLGMGQHPEVLQAMHETLDKYGAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  294 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 373
Cdd:TIGR01821  79 AGGTRNISGTNIPHVELEAELADLHGKESALVFTSGYVANDATLATLAKIIPGCVIFSDELNHASMIEGIRHSGAEKFIF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  374 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 406
Cdd:TIGR01821 159 RHNDVAHLEKLLQSVDPNRPKIIAFESVYSMDGdiapieeicdladkygaltyldevhavglygprgggiaerdglmhri 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  407 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEgrVLRRQHQRNVKLMRQMLM 478
Cdd:TIGR01821 239 diiegtlaKAFGVVGGYIAASRKLIDAIRSYAPGFIFTTSLPPAIAAGATASIRHLKESQ--DLRRAHQENVKRLKNLLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  479 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 558
Cdd:TIGR01821 317 ALGIPVIPNPSHIVPVIIGDAALCKKVSDLLLNKHGIYVQPINYPTVPRGTERLRITPTPAHTDKMIDDLVEALLLVWDR 396


                  ....*.
gi 767922627  559 VGLELK 564
Cdd:TIGR01821 397 LGLPLS 402
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 214-570 1.35e-140

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 414.25  E-value: 1.35e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 214 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 293
Cdd:PRK13392   2 MNYDSYFDAALAQLHQEGRYRVFADLEREAGRFPRARDHGPD--GPRRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 294 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 373
Cdd:PRK13392  80 AGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALSTLGKLLPGCVILSDALNHASMIEGIRRSGAEKQVF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 374 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 406
Cdd:PRK13392 160 RHNDLADLEEQLASVDPDRPKLIAFESVYSMDGdiapieaicdladrynaltyvdevhavglygargggiaerdglmdri 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLM 478
Cdd:PRK13392 240 dmiqgtlaKAFGCLGGYIAASADLIDFVRSFAPGFIFTTALPPAVAAGATAAIRHLKTSQTE--RDAHQDRVAALKAKLN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 479 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 558
Cdd:PRK13392 318 ANGIPVMPSPSHIVPVMVGDPTLCKAISDRLMSEHGIYIQPINYPTVPRGTERLRITPTPLHDDEDIDALVAALVAIWDR 397

                        410
                 ....*....|..
gi 767922627 559 VGLELKPHSSAE 570
Cdd:PRK13392 398 LELPRWREAAQA 409
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 260-560 5.66e-138

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 405.41  E-value: 5.66e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 260 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 339
Cdd:cd06454    1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 340 LakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSD-PSVPKIVAFETVHSMDG------------ 406
Cdd:cd06454   81 L--AGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLREARrPYGKKLIVTEGVYSMDGdiaplpelvdla 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 -------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPML 443
Cdd:cd06454  159 kkygailfvdeahsvgvygphgrgveefggltddvdiimgtlgKAFGAVGGYIAGSKELIDYLRSYARGFIFSTSLPPAV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 444 LAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVAD-AAKNTEVCDELMSRhNIYVQAINY 522
Cdd:cd06454  239 AAAALAALEVLQGGPER--RERLQENVRYLRRGLKELGFPVGGSPSHIIPPLIGDdPAKAVAFSDALLER-GIYVQAIRY 315

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767922627 523 PTVPRGEELLRIAPTPHHTPQMMNYFLENLlvtwKQVG 560
Cdd:cd06454  316 PTVPRGTARLRISLSAAHTKEDIDRLLEAL----KEVG 349
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 216-558 1.13e-125

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 375.16  E-value: 1.13e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 216 YDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDysdslitkKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAG 295
Cdd:COG0156    1 LLDRLEAELAALKAAGLYRYLRVLESPQGPRVTIDG--------REVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 296 GTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 375
Cdd:COG0156   73 GSRLVSGTTPLHEELEEELAEFLGKEAALLFSSGYAANLGVISALAG--RGDLIFSDELNHASIIDGARLSGAKVVRFRH 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 376 NDVSHLRELLQRSDPSVPKIVAFETVHSMDG------------------------------------------------- 406
Cdd:COG0156  151 NDMDDLERLLKKARAARRKLIVTDGVFSMDGdiaplpeivelaekygallyvddahgtgvlgetgrglvehfgledrvdi 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 ------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDA 480
Cdd:COG0156  231 imgtlsKALGSSGGFVAGSKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPEL--RERLWENIAYFREGLKEL 308

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767922627 481 GLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 558
Cdd:COG0156  309 GFDLGPSESPIVPVIVGDAERALALADALLER-GIYVSAIRPPTVPKGTARLRITLSAAHTEEDIDRLLEALAEVGKE 385
Preseq_ALAS pfam09029
5-aminolevulinate synthase presequence; The N terminal presequence domain found in ...
 19-154 1.16e-54

5-aminolevulinate synthase presequence; The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.


Pssm-ID: 462658  Cd Length: 114  Bit Score: 181.15  E-value: 1.16e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627   19 ESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMevgakpaPRALSTAAVHYQQIKE-TPPASEKDKTAKAkvqqtpd 97
Cdd:pfam09029   1 ASVLRRCPFLSRVPQAFLQKARKSLLSYAQRCPVMM-------TRALSTSSANLQGEKEeTPVAGPTAKQAKA------- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767922627   98 gsqqspdgtqLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEM 154
Cdd:pfam09029  67 ----------LPLGHPSPQAGQSVASKCPFLAAEMGQKNSNVVRKASPEVQEDVQEV 113
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
265-550 6.75e-45

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 162.86  E-value: 6.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  265 WCSNDYLGMsrhprVCGAVMDTLKQhgAGAGGTRNISGTSKFHVDLERELADLHG--------KDAALLFSSCFVANDST 336
Cdd:pfam00155   6 LGSNEYLGD-----TLPAVAKAEKD--ALAGGTRNLYGPTDGHPELREALAKFLGrspvlkldREAAVVFGSGAGANIEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  337 LFTLAKMmPGCEIYSDSGNHASMIQGIRNSRVPKYIFR-------HNDVSHLRELLQRSdpsvPKIVAFETVHSMDG--- 406
Cdd:pfam00155  79 LIFLLAN-PGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK----PKVVLHTSPHNPTGtva 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  407 -------------------------------------------------------KAFGCVG---GYIASTSSLIDTVRS 428
Cdd:pfam00155 154 tleeleklldlakehnilllvdeayagfvfgspdavatrallaegpnllvvgsfsKAFGLAGwrvGYILGNAAVISQLRK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  429 YAAGFIFTTSLPPMLLAGALESvrILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDE 508
Cdd:pfam00155 234 LARPFYSSTHLQAAAAAALSDP--LLVASELEEMRQRIKERRDYLRDGLQAAGLSVLPSQAGFFLLTGLDPETAKELAQV 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 767922627  509 LMSRHNIYVQAINYPTVPrgeELLRIAPTpHHTPQMMNYFLE 550
Cdd:pfam00155 312 LLEEVGVYVTPGSSPGVP---GWLRITVA-GGTEEELEELLE 349
 
Name Accession Description Interval E-value
5aminolev_synth TIGR01821
5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an ...
 214-564 0e+00

5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an enzyme for one of two routes to the heme precursor 5-aminolevulinate. The protein is a pyridoxal phosphate-dependent enzyme related to 2-amino-3-ketobutyrate CoA tranferase and 8-amino-7-oxononanoate synthase. This enzyme appears restricted to the alpha Proteobacteria and mitochondrial derivatives. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273820 [Multi-domain]  Cd Length: 402  Bit Score: 548.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  214 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 293
Cdd:TIGR01821   1 MDYDQFFNKEIDKLHLEGRYRVFADLERQAGEFPFAQWHRPD--GAKDVTVWCSNDYLGMGQHPEVLQAMHETLDKYGAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  294 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 373
Cdd:TIGR01821  79 AGGTRNISGTNIPHVELEAELADLHGKESALVFTSGYVANDATLATLAKIIPGCVIFSDELNHASMIEGIRHSGAEKFIF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  374 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 406
Cdd:TIGR01821 159 RHNDVAHLEKLLQSVDPNRPKIIAFESVYSMDGdiapieeicdladkygaltyldevhavglygprgggiaerdglmhri 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  407 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEgrVLRRQHQRNVKLMRQMLM 478
Cdd:TIGR01821 239 diiegtlaKAFGVVGGYIAASRKLIDAIRSYAPGFIFTTSLPPAIAAGATASIRHLKESQ--DLRRAHQENVKRLKNLLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  479 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 558
Cdd:TIGR01821 317 ALGIPVIPNPSHIVPVIIGDAALCKKVSDLLLNKHGIYVQPINYPTVPRGTERLRITPTPAHTDKMIDDLVEALLLVWDR 396


                  ....*.
gi 767922627  559 VGLELK 564
Cdd:TIGR01821 397 LGLPLS 402
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 214-570 1.35e-140

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 414.25  E-value: 1.35e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 214 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 293
Cdd:PRK13392   2 MNYDSYFDAALAQLHQEGRYRVFADLEREAGRFPRARDHGPD--GPRRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 294 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 373
Cdd:PRK13392  80 AGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALSTLGKLLPGCVILSDALNHASMIEGIRRSGAEKQVF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 374 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 406
Cdd:PRK13392 160 RHNDLADLEEQLASVDPDRPKLIAFESVYSMDGdiapieaicdladrynaltyvdevhavglygargggiaerdglmdri 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLM 478
Cdd:PRK13392 240 dmiqgtlaKAFGCLGGYIAASADLIDFVRSFAPGFIFTTALPPAVAAGATAAIRHLKTSQTE--RDAHQDRVAALKAKLN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 479 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 558
Cdd:PRK13392 318 ANGIPVMPSPSHIVPVMVGDPTLCKAISDRLMSEHGIYIQPINYPTVPRGTERLRITPTPLHDDEDIDALVAALVAIWDR 397

                        410
                 ....*....|..
gi 767922627 559 VGLELKPHSSAE 570
Cdd:PRK13392 398 LELPRWREAAQA 409
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 260-560 5.66e-138

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 405.41  E-value: 5.66e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 260 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 339
Cdd:cd06454    1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 340 LakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSD-PSVPKIVAFETVHSMDG------------ 406
Cdd:cd06454   81 L--AGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLREARrPYGKKLIVTEGVYSMDGdiaplpelvdla 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 -------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPML 443
Cdd:cd06454  159 kkygailfvdeahsvgvygphgrgveefggltddvdiimgtlgKAFGAVGGYIAGSKELIDYLRSYARGFIFSTSLPPAV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 444 LAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVAD-AAKNTEVCDELMSRhNIYVQAINY 522
Cdd:cd06454  239 AAAALAALEVLQGGPER--RERLQENVRYLRRGLKELGFPVGGSPSHIIPPLIGDdPAKAVAFSDALLER-GIYVQAIRY 315

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767922627 523 PTVPRGEELLRIAPTPHHTPQMMNYFLENLlvtwKQVG 560
Cdd:cd06454  316 PTVPRGTARLRISLSAAHTKEDIDRLLEAL----KEVG 349
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 216-558 1.13e-125

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 375.16  E-value: 1.13e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 216 YDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDysdslitkKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAG 295
Cdd:COG0156    1 LLDRLEAELAALKAAGLYRYLRVLESPQGPRVTIDG--------REVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 296 GTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 375
Cdd:COG0156   73 GSRLVSGTTPLHEELEEELAEFLGKEAALLFSSGYAANLGVISALAG--RGDLIFSDELNHASIIDGARLSGAKVVRFRH 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 376 NDVSHLRELLQRSDPSVPKIVAFETVHSMDG------------------------------------------------- 406
Cdd:COG0156  151 NDMDDLERLLKKARAARRKLIVTDGVFSMDGdiaplpeivelaekygallyvddahgtgvlgetgrglvehfgledrvdi 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 ------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDA 480
Cdd:COG0156  231 imgtlsKALGSSGGFVAGSKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPEL--RERLWENIAYFREGLKEL 308

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767922627 481 GLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 558
Cdd:COG0156  309 GFDLGPSESPIVPVIVGDAERALALADALLER-GIYVSAIRPPTVPKGTARLRITLSAAHTEEDIDRLLEALAEVGKE 385
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 220-552 3.62e-73

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 239.29  E-value: 3.62e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 220 FEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDysdslitkKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRN 299
Cdd:PRK05958   7 LEAALAQRRAAGLYRSLRPREGGAGRWLVVDG--------RRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 300 ISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVS 379
Cdd:PRK05958  79 VTGNSPAHEALEEELAEWFGAERALLFSSGYAANLAVLTAL--AGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 380 HLRELLQRSDPSvPKIVAFETVHSMDG----------------------------------------------------- 406
Cdd:PRK05958 157 ALEALLAKWRAG-RALIVTESVFSMDGdlaplaelvalarrhgawllvdeahgtgvlgpqgrglaaeaglagepdvilvg 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 ---KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGrvlRRQH-QRNVKLMRQMLMDAGL 482
Cdd:PRK05958 236 tlgKALGSSGAAVLGSETLIDYLINRARPFIFTTALPPAQAAAARAALRILRREPE---RRERlAALIARLRAGLRALGF 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 483 PVVHCPSHIIPVRVADAAKNTEVCDELmSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENL 552
Cdd:PRK05958 313 QLMDSQSAIQPLIVGDNERALALAAAL-QEQGFWVGAIRPPTVPAGTSRLRITLTAAHTEADIDRLLEAL 381
bioF TIGR00858
8-amino-7-oxononanoate synthase; 7-keto-8-aminopelargonic acid synthetase is an alternate name. ...
 260-552 1.91e-71

8-amino-7-oxononanoate synthase; 7-keto-8-aminopelargonic acid synthetase is an alternate name. This model represents 8-amino-7-oxononanoate synthase, the BioF protein of biotin biosynthesis. This model is based on a careful phylogenetic analysis to separate members of this family from 2-amino-3-ketobutyrate and other related pyridoxal phosphate-dependent enzymes. In several species, including Staphylococcus and Coxiella, a candidate 8-amino-7-oxononanoate synthase is confirmed by location in the midst of a biotin biosynthesis operon but scores below the trusted cutoff of this model. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273303 [Multi-domain]  Cd Length: 360  Bit Score: 234.08  E-value: 1.91e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  260 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 339
Cdd:TIGR00858  16 RRLLNFSSNDYLGLASHPEVIQAAQQGAEQYGAGSTASRLVSGNSPLHEELEEELAEWKGTEAALLFSSGYLANVGVISA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  340 LAKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG------------- 406
Cdd:TIGR00858  96 LVG--KGDLILSDALNHASLIDGCRLSGARVRRYRHNDVEHLERLLEKNRGERRKLIVTDGVFSMDGdiaplpqlvalae 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  407 -------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPML 443
Cdd:TIGR00858 174 rygawlmvddahgtgvlgedgrgtlehfglkpepvdiqvgtlsKALGSYGAYVAGSQALIDYLINRARTLIFSTALPPAV 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  444 LAGALESVRILksAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYP 523
Cdd:TIGR00858 254 AAAALAALELI--QEEPWRREKLLALIARLRAGLEALGFTLMPSCTPIVPVIIGDNASALALAEELQQQ-GIFVGAIRPP 330

                         330       340
                  ....*....|....*....|....*....
gi 767922627  524 TVPRGEELLRIAPTPHHTPQMMNYFLENL 552
Cdd:TIGR00858 331 TVPAGTSRLRLTLSAAHTPGDIDRLAEAL 359
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 219-564 8.00e-58

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 199.27  E-value: 8.00e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 219 FFEKKIDEKKNDHTY---RVFKTVNRrAHIfpmaddysdSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAG 295
Cdd:PRK06939   8 QLREELEEIKAEGLYkeeRVITSPQG-ADI---------TVADGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 296 GTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 375
Cdd:PRK06939  78 SVRFICGTQDLHKELEEKLAKFLGTEDAILYSSCFDANGGLFETL--LGKEDAIISDALNHASIIDGVRLCKAKRYRYAN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 376 NDVSHLRELLQRSDPSVP--KIVAFETVHSMDG----------------------------------------------- 406
Cdd:PRK06939 156 NDMADLEAQLKEAKEAGArhKLIATDGVFSMDGdiaplpeicdladkydalvmvddshavgfvgengrgtvehfgvmdrv 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 --------KAF-GCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKsaEGRVLRRQHQRNVKLMRQML 477
Cdd:PRK06939 236 diitgtlgKALgGASGGYTAGRKEVIDWLRQRSRPYLFSNSLAPAIVAASIKVLELLE--ESDELRDRLWENARYFREGM 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 478 MDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLEnllvTWK 557
Cdd:PRK06939 314 TAAGFTLGPGEHPIIPVMLGDAKLAQEFADRLLEE-GVYVIGFSFPVVPKGQARIRTQMSAAHTKEQLDRAID----AFE 388


                 ....*..
gi 767922627 558 QVGLELK 564
Cdd:PRK06939 389 KVGKELG 395
Preseq_ALAS pfam09029
5-aminolevulinate synthase presequence; The N terminal presequence domain found in ...
 19-154 1.16e-54

5-aminolevulinate synthase presequence; The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.


Pssm-ID: 462658  Cd Length: 114  Bit Score: 181.15  E-value: 1.16e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627   19 ESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMevgakpaPRALSTAAVHYQQIKE-TPPASEKDKTAKAkvqqtpd 97
Cdd:pfam09029   1 ASVLRRCPFLSRVPQAFLQKARKSLLSYAQRCPVMM-------TRALSTSSANLQGEKEeTPVAGPTAKQAKA------- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767922627   98 gsqqspdgtqLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEM 154
Cdd:pfam09029  67 ----------LPLGHPSPQAGQSVASKCPFLAAEMGQKNSNVVRKASPEVQEDVQEV 113
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
265-550 6.75e-45

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 162.86  E-value: 6.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  265 WCSNDYLGMsrhprVCGAVMDTLKQhgAGAGGTRNISGTSKFHVDLERELADLHG--------KDAALLFSSCFVANDST 336
Cdd:pfam00155   6 LGSNEYLGD-----TLPAVAKAEKD--ALAGGTRNLYGPTDGHPELREALAKFLGrspvlkldREAAVVFGSGAGANIEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  337 LFTLAKMmPGCEIYSDSGNHASMIQGIRNSRVPKYIFR-------HNDVSHLRELLQRSdpsvPKIVAFETVHSMDG--- 406
Cdd:pfam00155  79 LIFLLAN-PGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK----PKVVLHTSPHNPTGtva 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  407 -------------------------------------------------------KAFGCVG---GYIASTSSLIDTVRS 428
Cdd:pfam00155 154 tleeleklldlakehnilllvdeayagfvfgspdavatrallaegpnllvvgsfsKAFGLAGwrvGYILGNAAVISQLRK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627  429 YAAGFIFTTSLPPMLLAGALESvrILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDE 508
Cdd:pfam00155 234 LARPFYSSTHLQAAAAAALSDP--LLVASELEEMRQRIKERRDYLRDGLQAAGLSVLPSQAGFFLLTGLDPETAKELAQV 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 767922627  509 LMSRHNIYVQAINYPTVPrgeELLRIAPTpHHTPQMMNYFLE 550
Cdd:pfam00155 312 LLEEVGVYVTPGSSPGVP---GWLRITVA-GGTEEELEELLE 349
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 260-543 7.91e-29

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 120.16  E-value: 7.91e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 260 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 339
Cdd:PLN02955 102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAANMAAMVA 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 340 L--------AKMMP----GCEIYSDSGNHASMIQGI----RNSRVPKYIFRHNDVSHLRELLQRSDPSvPKIVAFETVHS 403
Cdd:PLN02955 182 IgsvasllaASGKPlkneKVAIFSDALNHASIIDGVrlaeRQGNVEVFVYRHCDMYHLNSLLSSCKMK-RKVVVTDSLFS 260

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 404 MDG-------------------------------------------------------KAFGCVGGYIASTSSLIDTVRS 428
Cdd:PLN02955 261 MDGdfapmeelsqlrkkygfllviddahgtfvcgengggvaeefnceadvdlcvgtlsKAAGCHGGFIACSKKWKQLIQS 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 429 YAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMlmdAGLPVvhcPSHIIPVRVADAAKNTEVCDE 508
Cdd:PLN02955 341 RGRSFIFSTAIPVPMAAAAYAAVVVARKEKWR--RKAIWERVKEFKAL---SGVDI---SSPIISLVVGNQEKALKASRY 412

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 767922627 509 LMsRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQ 543
Cdd:PLN02955 413 LL-KSGFHVMAIRPPTVPPNSCRLRVTLSAAHTTE 446
PLN02483 PLN02483
serine palmitoyltransferase
 267-570 3.18e-28

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 118.33  E-value: 3.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 267 SNDYLGMSRHPRVCGA-VMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLakMMP 345
Cdd:PLN02483 107 SYNYLGFAAADEYCTPrVIESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYATNSTIIPAL--IGK 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 346 GCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQ--------RSDPSVPKI-VAFETVHSMDG---------- 406
Cdd:PLN02483 185 GGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLReqiaegqpRTHRPWKKIiVIVEGIYSMEGelcklpeiva 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 ----------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLP 440
Cdd:PLN02483 265 vckkykayvyldeahsigavgktgrgvcellgvdpadvdimmgtftKSFGSCGGYIAGSKELIQYLKRTCPAHLYATSMS 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 441 PMLLAGALESVRILKSAEG-----RVLRRQHQrNVKLMRQMLMDAGLPVV-HCPSHIIPVRVADAAKNTEVCDELMSRhN 514
Cdd:PLN02483 345 PPAVQQVISAIKVILGEDGtnrgaQKLAQIRE-NSNFFRSELQKMGFEVLgDNDSPVMPIMLYNPAKIPAFSRECLKQ-N 422

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767922627 515 IYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPHSSAE 570
Cdd:PLN02483 423 VAVVVVGFPATPLLLARARICISASHSREDLIKALEVISEVGDLVGIKYFPAEPKK 478
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
267-550 9.65e-27

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 112.80  E-value: 9.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 267 SNDYLGMSRHPRVCGAVMDTLKQHGagaggtRNISGTSKFHVD------LERELADLHGKDAALLFSSCFVANDSTLFTL 340
Cdd:PRK07179  61 SNDYLNLSGHPDIIKAQIAALQEEG------DSLVMSAVFLHDdspkpqFEKKLAAFTGFESCLLCQSGWAANVGLLQTI 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 341 AKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSvpkIVAFETVHSMDG------------KA 408
Cdd:PRK07179 135 AD--PNTPVYIDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQIERHGPG---IIVVDSVYSTTGtiapladivdiaEE 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 409 FGCV-------------------------------------------GGYIASTSSLIDTVR--SYAAgfIFTTSLPPML 443
Cdd:PRK07179 210 FGCVlvvdeshslgthgpqgaglvaelgltsrvhfitaslakafagrAGIITCPRELAEYVPfvSYPA--IFSSTLLPHE 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 444 LAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDAGLPvVHCPSHIIPVrVADAAKNTEVC-DELMSRhNIYVQAINY 522
Cdd:PRK07179 288 IAGLEATLEVIESADDR--RARLHANARFLREGLSELGYN-IRSESQIIAL-ETGSERNTEVLrDALEER-NVFGAVFCA 362

                        330       340
                 ....*....|....*....|....*...
gi 767922627 523 PTVPRGEELLRIAPTPHHTPQMMNYFLE 550
Cdd:PRK07179 363 PATPKNRNLIRLSLNADLTASDLDRVLE 390
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 264-515 1.19e-17

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 85.34  E-value: 1.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 264 VWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKM 343
Cdd:PLN03227   2 NFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAKR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 344 mpGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQR---SDPS------------------------VP--K 394
Cdd:PLN03227  82 --GDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQvraQDVAlkrkptdqrrflvveglykntgtlAPlkE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 395 IVAFETVHS----MD--------GK--------------------------AFGCVGGYIASTSSLIDTVRSYAAGFIFT 436
Cdd:PLN03227 160 LVALKEEFHyrliLDesfsfgtlGKsgrgslehaglkpmvhaeivtfslenAFGSVGGMTVGSEEVVDHQRLSGSGYCFS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 437 TSLPPMLLAGALESVRILKsAEGRVLRRQHQrNVKLMRQMLMDAGLPVVHCP-----------SHIIPVRVADAAKnTEV 505
Cdd:PLN03227 240 ASAPPFLAKADATATAGEL-AGPQLLNRLHD-SIANLYSTLTNSSHPYALKLrnrlvitsdpiSPIIYLRLSDQEA-TRR 316

                        330
                 ....*....|
gi 767922627 506 CDELMSRHNI 515
Cdd:PLN03227 317 TDETLILDQI 326
PLN02822 PLN02822
serine palmitoyltransferase
 257-479 1.01e-13

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 73.62  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 257 ITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDST 336
Cdd:PLN02822 106 INGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSV 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 337 LFTLAKMmpGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELL-----------------------QRSDPSVP 393
Cdd:PLN02822 186 IPAFCKK--GDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLekltaenkrkkklrryivveaiyQNSGQIAP 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 394 ---------------------------------------KIVAFETVHSMDGKAFGCVGGYIASTSSLIDTVRSYAAGFI 434
Cdd:PLN02822 264 ldeivrlkekyrfrvlldesnsfgvlgksgrglsehfgvPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYV 343

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767922627 435 FTTSLPPMLLAGALESVRILKSaEGRVLRRQHQrNVKLMRQMLMD 479
Cdd:PLN02822 344 FSASLPPYLASAAITAIDVLED-NPSVLAKLKE-NIALLHKGLSD 386
PRK07505 PRK07505
hypothetical protein; Provisional
 266-543 1.71e-12

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 69.62  E-value: 1.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 266 CSNDYLGMSRHPRVCGAVMDTLKqhgagAGGTRNISgTSKFHV------DLERELADLHGKDAaLLFSSCFVANDSTLFT 339
Cdd:PRK07505  52 VSCSYLGLDTHPAIIEGAVDALK-----RTGSLHLS-SSRTRVrsqilkDLEEALSELFGASV-LTFTSCSAAHLGILPL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 340 LAK--MMPGCEIYS--DSGNHASM--IQGIRNSRVPKYIFRHNDVSHLRELLQRSdpsvpKIVAF--ETVHSMDG----- 406
Cdd:PRK07505 125 LASghLTGGVPPHMvfDKNAHASLniLKGICADETEVETIDHNDLDALEDICKTN-----KTVAYvaDGVYSMGGiapvk 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 407 ---------------------------------------------------KAFGCVGGYIA-STSSLIDTVRSYAAGFI 434
Cdd:PRK07505 200 ellrlqekyglflyiddahglsiygkngegyvrseldyrlnertiiaaslgKAFGASGGVIMlGDAEQIELILRYAGPLA 279

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 435 FTTSLPPMLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMD--AGLPVvhcpshiiPVRVA---DAAKNTEVCDEL 509
Cdd:PRK07505 280 FSQSLNVAALGAILASAEIHLSEELDQLQQKLQNNIALFDSLIPTeqSGSFL--------PIRLIyigDEDTAIKAAKQL 351

                        330       340       350
                 ....*....|....*....|....*....|....
gi 767922627 510 MSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQ 543
Cdd:PRK07505 352 LDR-GFYTSPVFFPVVAKGRAGLRIMFRASHTND 384
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 267-386 2.20e-10

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 62.49  E-value: 2.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767922627 267 SNDYLGMSRHPRVCGAVMDTLKQH-------GAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 339
Cdd:PRK05937  11 TNDFLGFSRSDTLVHEVEKRYRLYcrqfphaQLGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLGLCAH 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767922627 340 LAKMMPgcEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQ 386
Cdd:PRK05937  91 LSSVTD--YVLWDEQVHISVVYSLSVISGWHQSFRHNDLDHLESLLE 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH