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Conserved domains on  [gi|1034633988|ref|XP_011532151|]
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interleukin-17 receptor D isoform X1 [Homo sapiens]

Protein Classification

IL17R_D_N and SEFIR domain-containing protein( domain architecture ID 11073309)

IL17R_D_N and SEFIR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 212-367 3.03e-57

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


:

Pssm-ID: 254756  Cd Length: 150  Bit Score: 189.14  E-value: 3.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633988 212 PKVFLCYSSkDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNY 291
Cdd:pfam08357   1 RKVFIVYSS-DSALHTEVVLKFAEFLQDYCGCEVALDLWELNEIAEIGPVAWLERQIQEADKVIIVCSKGAKAFCDKKAD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034633988 292 KHKGGGRGSGKGELFLVAVSAIaekLRQAKQssSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLCSHL 367
Cdd:pfam08357  80 KRKGGVGTESQHDLFIPALSLI---LRDFKQ--SAALRKYLVVYFGYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
IL17R_D_N super family cl25080
N-terminus of interleukin 17 receptor D; IL17R_D_N is found in higher eukaryotes. The function ...
 1-25 7.08e-10

N-terminus of interleukin 17 receptor D; IL17R_D_N is found in higher eukaryotes. The function of this N-terminal domain is not known.


The actual alignment was detected with superfamily member pfam16742:

Pssm-ID: 465254  Cd Length: 122  Bit Score: 57.15  E-value: 7.08e-10
                          10        20
                  ....*....|....*....|....*
gi 1034633988   1 MESQPFLNMKFETDYFVKVVPFPSI 25
Cdd:pfam16742  98 MSSQPFLNLKFETDYMVRIVPFPSF 122
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 212-367 3.03e-57

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 189.14  E-value: 3.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633988 212 PKVFLCYSSkDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNY 291
Cdd:pfam08357   1 RKVFIVYSS-DSALHTEVVLKFAEFLQDYCGCEVALDLWELNEIAEIGPVAWLERQIQEADKVIIVCSKGAKAFCDKKAD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034633988 292 KHKGGGRGSGKGELFLVAVSAIaekLRQAKQssSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLCSHL 367
Cdd:pfam08357  80 KRKGGVGTESQHDLFIPALSLI---LRDFKQ--SAALRKYLVVYFGYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
IL17R_D_N pfam16742
N-terminus of interleukin 17 receptor D; IL17R_D_N is found in higher eukaryotes. The function ...
 1-25 7.08e-10

N-terminus of interleukin 17 receptor D; IL17R_D_N is found in higher eukaryotes. The function of this N-terminal domain is not known.


Pssm-ID: 465254  Cd Length: 122  Bit Score: 57.15  E-value: 7.08e-10
                          10        20
                  ....*....|....*....|....*
gi 1034633988   1 MESQPFLNMKFETDYFVKVVPFPSI 25
Cdd:pfam16742  98 MSSQPFLNLKFETDYMVRIVPFPSF 122
 
Name Accession Description Interval E-value
SEFIR pfam08357
SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are ...
 212-367 3.03e-57

SEFIR domain; This family comprises IL17 receptors (IL17Rs) and SEF proteins. The latter are feedback inhibitors of FGF signalling and are also thought to be receptors. Due to its similarity to the TIR domain (pfam01582), the SEFIR region is thought to be involved in homotypic interactions with other SEFIR/TIR-domain-containing proteins. Thus, SEFs and IL17Rs may be involved in TOLL/IL1R-like signalling pathways.


Pssm-ID: 254756  Cd Length: 150  Bit Score: 189.14  E-value: 3.03e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633988 212 PKVFLCYSSkDGQNHMNVVQCFAYFLQDFCGCEVALDLWEDFSLCREGQREWVIQKIHESQFIIVVCSKGMKYFVDKKNY 291
Cdd:pfam08357   1 RKVFIVYSS-DSALHTEVVLKFAEFLQDYCGCEVALDLWELNEIAEIGPVAWLERQIQEADKVIIVCSKGAKAFCDKKAD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034633988 292 KHKGGGRGSGKGELFLVAVSAIaekLRQAKQssSAALSKFIAVYFDYSCEGDVPGILDLSTKYRLMDNLPQLCSHL 367
Cdd:pfam08357  80 KRKGGVGTESQHDLFIPALSLI---LRDFKQ--SAALRKYLVVYFGYADKKDVPTILRVLPKYSLMDQLPQLLAEL 150
IL17R_D_N pfam16742
N-terminus of interleukin 17 receptor D; IL17R_D_N is found in higher eukaryotes. The function ...
 1-25 7.08e-10

N-terminus of interleukin 17 receptor D; IL17R_D_N is found in higher eukaryotes. The function of this N-terminal domain is not known.


Pssm-ID: 465254  Cd Length: 122  Bit Score: 57.15  E-value: 7.08e-10
                          10        20
                  ....*....|....*....|....*
gi 1034633988   1 MESQPFLNMKFETDYFVKVVPFPSI 25
Cdd:pfam16742  98 MSSQPFLNLKFETDYMVRIVPFPSF 122
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 214-280 2.44e-03

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 38.07  E-value: 2.44e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034633988 214 VFLCYSSKDgqnhMNVVQCFAYFLQDfCGCEVALDLWEdfslCREGQR--EWVIQKIHESQFIIVVCSK 280
Cdd:pfam13676   1 VFISYAGED----RAWAEWLADALEA-AGYRVWLDRWD----IRPGDDwvEEIEEAIENSDRVLVVLSP 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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