NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767924350|ref|XP_011532438|]
View 

WD repeat-containing protein 82 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-222 7.79e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.50  E-value: 7.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEG 79
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  80 LIFAAGVNSEMVKLYDLRSFDkgPFATFKMQYDRTcewTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSk 159
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA- 332

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767924350 160 avTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACS 222
Cdd:COG2319  333 --VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-222 7.79e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.50  E-value: 7.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEG 79
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  80 LIFAAGVNSEMVKLYDLRSFDkgPFATFKMQYDRTcewTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSk 159
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA- 332

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767924350 160 avTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACS 222
Cdd:COG2319  333 --VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-220 4.45e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 4.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   7 NTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPEGLIFAA 84
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  85 GVNSEMVKLYDLRSFdkGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGyaNSKAVTlE 164
Cdd:cd00200  153 SSQDGTIKLWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HENGVN-S 224

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767924350 165 ASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASA 220
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-55 2.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 2.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767924350    16 DNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 55
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
17-55 2.80e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 2.80e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767924350   17 NKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 55
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-222 7.79e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.50  E-value: 7.79e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEG 79
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSvaFSPDG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  80 LIFAAGVNSEMVKLYDLRSFDkgPFATFKMQYDRTcewTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANSk 159
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGE--LLRTLTGHSGGV---NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA- 332

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767924350 160 avTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACS 222
Cdd:COG2319  333 --VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-220 4.45e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 4.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   7 NTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPEGLIFAA 84
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVnsVAFSPDGTFVAS 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  85 GVNSEMVKLYDLRSFdkGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGyaNSKAVTlE 164
Cdd:cd00200  153 SSQDGTIKLWDLRTG--KCVATLT---GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG--HENGVN-S 224

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767924350 165 ASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASA 220
Cdd:cd00200  225 VAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
2-223 1.93e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.25  E-value: 1.93e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEG 79
Cdd:COG2319   95 SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSvaFSPDG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  80 LIFAAGVNSEMVKLYDLRSFDkgPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANS- 158
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGK--LLRTLT---GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSv 249

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767924350 159 KAVtleaSFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACSN 223
Cdd:COG2319  250 RSV----AFSPDGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDD 309
WD40 COG2319
WD40 repeat [General function prediction only];
2-222 2.63e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 2.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPEG 79
Cdd:COG2319   53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVrsVAFSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  80 LIFAAGVNSEMVKLYDLRsfDKGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYANsk 159
Cdd:COG2319  133 KTLASGSADGTVRLWDLA--TGKLLRTLT---GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-- 205

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767924350 160 AVTlEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACS 222
Cdd:COG2319  206 AVR-SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSA 266
WD40 COG2319
WD40 repeat [General function prediction only];
2-187 3.10e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 3.10e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEG 79
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSvaFSPDG 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  80 LIFAAGVNSEMVKLYDLRSFDkgPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYanSK 159
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGK--LLRTLT---GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH--TG 373

                        170       180
                 ....*....|....*....|....*...
gi 767924350 160 AVTlEASFTPDSQFIMIGSEDGKIHVWN 187
Cdd:COG2319  374 AVT-SVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 20-228 2.80e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 2.80e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  20 IRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLM--HLQGKPVCSFDPEG-LIFAAGVNSeMVKLYDL 96
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkgHTGPVRDVAASADGtYLASGSSDK-TIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  97 RSFDKgpFATFKMQydrTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGyaNSKAVTlEASFTPDSQFIMI 176
Cdd:cd00200   81 ETGEC--VRTLTGH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWVN-SVAFSPDGTFVAS 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767924350 177 GSEDGKIHVWNGESGIKVAVLDGkHTGPITCLQFNPKFMTFASACSNMAFWL 228
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-187 1.31e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 1.31e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPvDDTFI-SGSLDKTIRLWDLRSPNCQGLMHLQGKPV--CSFDPE 78
Cdd:cd00200  110 SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVnsVAFSPD 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350  79 GLIFAAGVNSEMVKLYDLRSFDkgpfatFKMQYDRTCEW-TGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTFGGYAN 157
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLSTGK------CLGTLRGHENGvNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN 262

                        170       180       190
                 ....*....|....*....|....*....|
gi 767924350 158 SkaVTLeASFTPDSQFIMIGSEDGKIHVWN 187
Cdd:cd00200  263 S--VTS-LAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-143 1.66e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCS--FDPEG 79
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSvaFSPDG 342

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767924350  80 LIFAAGVNSEMVKLYDLRSfdKGPFATFKmqyDRTCEWTGLKFSNDGKLILISTNGSFIRLIDA 143
Cdd:COG2319  343 KTLASGSDDGTVRLWDLAT--GELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
2-58 1.87e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 1.87e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767924350   2 TARRANTIRYLSLHDNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRS 58
Cdd:COG2319  347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 16-55 2.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 2.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767924350    16 DNKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 55
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
17-55 2.80e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 2.80e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767924350   17 NKYIRYFPGHSKRVVALSMSPVDDTFISGSLDKTIRLWD 55
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 112-152 3.33e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 3.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767924350  112 DRTCEWTGLKFSNDGKLILISTNGSFIRLIDAFKGVVMHTF 152
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH