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Conserved domains on  [gi|767924716|ref|XP_011532583|]
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TBC1 domain family member 5 isoform X1 [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 10640016)

TBC (Tre-2/Bub2/Cdc1) domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
79-381 9.53e-55

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 188.28  E-value: 9.53e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716    79 GQLRSSRFRSICWKLFLCVLPQDKSQWisrieelRAWYSNIKEIHITNPRKVVgqqdlminnplsqdegslwnkffqdke 158
Cdd:smart00164   2 RKGVPPSLRGVVWKLLLNAQPMDTSAD-------KDLYSRLLKETAPDDKSIV--------------------------- 47
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   159 lrSMIEQDVKRTFPEMQFFQQEN--VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLhcdhqaflhasesaqpsee 236
Cdd:smart00164  48 --HQIEKDLRRTFPEHSFFQDKEgpGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM------------------- 106
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   237 mktvlnpeYLEHDAYAVFSQLMETAEPWFSTFEHDGqkgketlmtpipfarpqdlgptiaiVTKVNQIQDHLLKKHDIEL 316
Cdd:smart00164 107 --------EDEEDAFWCLVKLMERYGPNFYLPDMSG-------------------------LQLDLLQLDRLVKEYDPDL 153
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767924716   317 YMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGlsLGLVDYIFVAMLLYIRDALI 381
Cdd:smart00164 154 YKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEG--SDFLFRVALALLKLHRDVLL 216
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
79-381 9.53e-55

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 188.28  E-value: 9.53e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716    79 GQLRSSRFRSICWKLFLCVLPQDKSQWisrieelRAWYSNIKEIHITNPRKVVgqqdlminnplsqdegslwnkffqdke 158
Cdd:smart00164   2 RKGVPPSLRGVVWKLLLNAQPMDTSAD-------KDLYSRLLKETAPDDKSIV--------------------------- 47
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   159 lrSMIEQDVKRTFPEMQFFQQEN--VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLhcdhqaflhasesaqpsee 236
Cdd:smart00164  48 --HQIEKDLRRTFPEHSFFQDKEgpGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM------------------- 106
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   237 mktvlnpeYLEHDAYAVFSQLMETAEPWFSTFEHDGqkgketlmtpipfarpqdlgptiaiVTKVNQIQDHLLKKHDIEL 316
Cdd:smart00164 107 --------EDEEDAFWCLVKLMERYGPNFYLPDMSG-------------------------LQLDLLQLDRLVKEYDPDL 153
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767924716   317 YMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGlsLGLVDYIFVAMLLYIRDALI 381
Cdd:smart00164 154 YKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEG--SDFLFRVALALLKLHRDVLL 216
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
163-381 1.28e-26

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 107.34  E-value: 1.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716  163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPivfvlhcdhqaFLHASESaqpseemktvln 242
Cdd:pfam00566  12 IEKDVPRTFPHSFFFDNGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAP-----------LLLVYLD------------ 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716  243 peylEHDAYAVFSQLMETAEPWfSTFEHDGQKGKETLmtpipfarpqdlgptiaivtkvnQIQDHLLKKHDIELYMHLNR 322
Cdd:pfam00566  69 ----EEDAFWCFVSLLENYLLR-DFYTPDFPGLKRDL-----------------------YVFEELLKKKLPKLYKHLKE 120
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767924716  323 LEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVdYIFVAMLLYIRDALI 381
Cdd:pfam00566 121 LGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLF-RVALAILKRFREELL 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
4-384 2.48e-12

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 70.22  E-value: 2.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   4 SLSETRHPLQPEEQEVGIDPLSSYSnksgGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIR---------- 73
Cdd:COG5210   79 EELPTLLETADRSSSPGNESLSAVV----SNFGLNNKSLKSQSTSPELPKRLKDSLPTHLPEASSTEKDFssfkgsssln 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716  74 ------QKGINGQLRSSRFRSICWKLFLCVLPQD------KSQWISRIEELRA-WYSNIKEIHitnpRKVVGQQDLMINN 140
Cdd:COG5210  155 snpelnKEINELSLKEEPQKLRYYELAADKLWISyldpnpLSFLPVQLSKLRElIRKGIPNEL----RGDVWEFLLGIGF 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716 141 PLSQDEG---SLWNK----FFQDKELRSMIEQDVKRTFPEMQFFQQENVR--KILTDVLFCYARENEQLLYKQGMHELLA 211
Cdd:COG5210  231 DLDKNPGlyeRLLNLhreaKIPTQEIISQIEKDLSRTFPDNSLFQTEISIraENLRRVLKAYSLYNPEVGYVQGMNFLAA 310
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716 212 PIVFVLhcdhqaflhasesaqPSEEmktvlnpeylehDAYAVFSQLMEtaepwfstfehdgQKGKETLmtpipFARPQDL 291
Cdd:COG5210  311 PLLLVL---------------ESEE------------QAFWCLVKLLK-------------NYGLPGY-----FLKNLSG 345
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716 292 GPTIAIVtkvnqiQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVdyIFVA 371
Cdd:COG5210  346 LHRDLKV------LDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQ--LALA 417
                        410
                 ....*....|...
gi 767924716 372 MLLYIRDALISSN 384
Cdd:COG5210  418 ILKLLRDKLLKLD 430
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
79-381 9.53e-55

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 188.28  E-value: 9.53e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716    79 GQLRSSRFRSICWKLFLCVLPQDKSQWisrieelRAWYSNIKEIHITNPRKVVgqqdlminnplsqdegslwnkffqdke 158
Cdd:smart00164   2 RKGVPPSLRGVVWKLLLNAQPMDTSAD-------KDLYSRLLKETAPDDKSIV--------------------------- 47
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   159 lrSMIEQDVKRTFPEMQFFQQEN--VRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLhcdhqaflhasesaqpsee 236
Cdd:smart00164  48 --HQIEKDLRRTFPEHSFFQDKEgpGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM------------------- 106
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   237 mktvlnpeYLEHDAYAVFSQLMETAEPWFSTFEHDGqkgketlmtpipfarpqdlgptiaiVTKVNQIQDHLLKKHDIEL 316
Cdd:smart00164 107 --------EDEEDAFWCLVKLMERYGPNFYLPDMSG-------------------------LQLDLLQLDRLVKEYDPDL 153
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767924716   317 YMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGlsLGLVDYIFVAMLLYIRDALI 381
Cdd:smart00164 154 YKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEG--SDFLFRVALALLKLHRDVLL 216
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
163-381 1.28e-26

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 107.34  E-value: 1.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716  163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPivfvlhcdhqaFLHASESaqpseemktvln 242
Cdd:pfam00566  12 IEKDVPRTFPHSFFFDNGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAP-----------LLLVYLD------------ 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716  243 peylEHDAYAVFSQLMETAEPWfSTFEHDGQKGKETLmtpipfarpqdlgptiaivtkvnQIQDHLLKKHDIELYMHLNR 322
Cdd:pfam00566  69 ----EEDAFWCFVSLLENYLLR-DFYTPDFPGLKRDL-----------------------YVFEELLKKKLPKLYKHLKE 120
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767924716  323 LEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVdYIFVAMLLYIRDALI 381
Cdd:pfam00566 121 LGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVLF-RVALAILKRFREELL 178
COG5210 COG5210
GTPase-activating protein [General function prediction only];
4-384 2.48e-12

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 70.22  E-value: 2.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716   4 SLSETRHPLQPEEQEVGIDPLSSYSnksgGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIR---------- 73
Cdd:COG5210   79 EELPTLLETADRSSSPGNESLSAVV----SNFGLNNKSLKSQSTSPELPKRLKDSLPTHLPEASSTEKDFssfkgsssln 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716  74 ------QKGINGQLRSSRFRSICWKLFLCVLPQD------KSQWISRIEELRA-WYSNIKEIHitnpRKVVGQQDLMINN 140
Cdd:COG5210  155 snpelnKEINELSLKEEPQKLRYYELAADKLWISyldpnpLSFLPVQLSKLRElIRKGIPNEL----RGDVWEFLLGIGF 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716 141 PLSQDEG---SLWNK----FFQDKELRSMIEQDVKRTFPEMQFFQQENVR--KILTDVLFCYARENEQLLYKQGMHELLA 211
Cdd:COG5210  231 DLDKNPGlyeRLLNLhreaKIPTQEIISQIEKDLSRTFPDNSLFQTEISIraENLRRVLKAYSLYNPEVGYVQGMNFLAA 310
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716 212 PIVFVLhcdhqaflhasesaqPSEEmktvlnpeylehDAYAVFSQLMEtaepwfstfehdgQKGKETLmtpipFARPQDL 291
Cdd:COG5210  311 PLLLVL---------------ESEE------------QAFWCLVKLLK-------------NYGLPGY-----FLKNLSG 345
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767924716 292 GPTIAIVtkvnqiQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVdyIFVA 371
Cdd:COG5210  346 LHRDLKV------LDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQ--LALA 417
                        410
                 ....*....|...
gi 767924716 372 MLLYIRDALISSN 384
Cdd:COG5210  418 ILKLLRDKLLKLD 430
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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