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Conserved domains on  [gi|767938378|ref|XP_011532854|]
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magnesium transporter NIPA4 isoform X1 [Homo sapiens]

Protein Classification

DMT family transporter( domain architecture ID 581036)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0005215|GO:0005886
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EamA super family cl23754
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
1-245 2.35e-97

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


The actual alignment was detected with superfamily member pfam05653:

Pssm-ID: 474045  Cd Length: 295  Bit Score: 288.59  E-value: 2.35e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378    1 MWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVT 80
Cdd:pfam05653  51 LWWAGLLTMGVGEAANFAAYAFAPATLVTPLGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIE 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378   81 TIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPL 160
Cdd:pfam05653 131 SLREVWHLLTDPGFLVYVILVVGVVLALILYFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPI 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378  161 PYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLH 240
Cdd:pfam05653 211 AWILLLVMITCCVTQINYLNKALDIFNTSIVTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLH 290

                  ....*
gi 767938378  241 AFKDL 245
Cdd:pfam05653 291 AFRDK 295
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
1-245 2.35e-97

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 288.59  E-value: 2.35e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378    1 MWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVT 80
Cdd:pfam05653  51 LWWAGLLTMGVGEAANFAAYAFAPATLVTPLGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIE 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378   81 TIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPL 160
Cdd:pfam05653 131 SLREVWHLLTDPGFLVYVILVVGVVLALILYFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPI 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378  161 PYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLH 240
Cdd:pfam05653 211 AWILLLVMITCCVTQINYLNKALDIFNTSIVTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLH 290

                  ....*
gi 767938378  241 AFKDL 245
Cdd:pfam05653 291 AFRDK 295
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
7-71 1.26e-04

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 41.32  E-value: 1.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767938378   7 LTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVI 71
Cdd:COG2510   73 LATGLSWLFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSL 137
 
Name Accession Description Interval E-value
Mg_trans_NIPA pfam05653
Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family ...
1-245 2.35e-97

Magnesium transporter NIPA; NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters.


Pssm-ID: 398984  Cd Length: 295  Bit Score: 288.59  E-value: 2.35e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378    1 MWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIHAPEEEKVT 80
Cdd:pfam05653  51 LWWAGLLTMGVGEAANFAAYAFAPATLVTPLGALSVIISAVLASFFLKEKLNLSGKLGCVLCILGSTVIVIHAPKEQEIE 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378   81 TIMEMASKMKDTGFIVFAVLLLVSCLILIFVIAPRYGQRNILIYIIICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPL 160
Cdd:pfam05653 131 SLREVWHLLTDPGFLVYVILVVGVVLALILYFEPRHGQTNIVVYITICSLIGSLTVMSVKAVGIAIKLTFTGKNQLTYPI 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767938378  161 PYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSIILFKEWYSMSAVDIAGTLSGFVTIILGVFMLH 240
Cdd:pfam05653 211 AWILLLVMITCCVTQINYLNKALDIFNTSIVTPVYYVMFTTSVIIASAILFKEWLGMAFLDVAGELCGFFTVITGVFLLH 290

                  ....*
gi 767938378  241 AFKDL 245
Cdd:pfam05653 291 AFRDK 295
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
7-71 1.26e-04

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 41.32  E-value: 1.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767938378   7 LTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVI 71
Cdd:COG2510   73 LATGLSWLFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILLSL 137
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
1-72 2.46e-03

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 38.67  E-value: 2.46e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767938378   1 MWWAGFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVIH 72
Cdd:COG0697   68 LLLRGLLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGP 139
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
5-71 3.34e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 37.17  E-value: 3.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767938378    5 GFLTMAAGEVANFGAYAFAPATVVTPLGALSVLISAILSSYFLRESLNLLGKLGCVICVAGSTVMVI 71
Cdd:pfam00892  70 GVLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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