poly(A)-specific ribonuclease PNLDC1 isoform X7 [Homo sapiens]
Protein Classification
CAF1 family ribonuclease( domain architecture ID 10522102)
CAF1 family ribonuclease such as human poly(A)-specific ribonuclease PNLDC1, a 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, and target of EGR1 protein 1 (TOE1) that inhibits cell growth rate and cell cycle
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| CAF1 | pfam04857 | CAF1 family ribonuclease; The major pathways of mRNA turnover in eukaryotes initiate with ... |
30-246 | 1.90e-50 | ||||
CAF1 family ribonuclease; The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localizes to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain pfam01424. This family of proteins is related to other exonucleases pfam00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 has been resolved at 2.3 Angstrom resolution. : Pssm-ID: 461457 Cd Length: 375 Bit Score: 174.14 E-value: 1.90e-50
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| Name | Accession | Description | Interval | E-value | ||||
| CAF1 | pfam04857 | CAF1 family ribonuclease; The major pathways of mRNA turnover in eukaryotes initiate with ... |
30-246 | 1.90e-50 | ||||
CAF1 family ribonuclease; The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localizes to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain pfam01424. This family of proteins is related to other exonucleases pfam00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 has been resolved at 2.3 Angstrom resolution. Pssm-ID: 461457 Cd Length: 375 Bit Score: 174.14 E-value: 1.90e-50
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| Name | Accession | Description | Interval | E-value | ||||
| CAF1 | pfam04857 | CAF1 family ribonuclease; The major pathways of mRNA turnover in eukaryotes initiate with ... |
30-246 | 1.90e-50 | ||||
CAF1 family ribonuclease; The major pathways of mRNA turnover in eukaryotes initiate with shortening of the polyA tail. CAF1 encodes a critical component of the major cytoplasmic deadenylase in yeast. Both Caf1p is required for normal mRNA deadenylation in vivo and localizes to the cytoplasm. Caf1p copurifies with a Ccr4p-dependent polyA-specific exonuclease activity. Some members of this family include and inserted RNA binding domain pfam01424. This family of proteins is related to other exonucleases pfam00929 (Bateman A pers. obs.). The crystal structure of Saccharomyces cerevisiae Pop2 has been resolved at 2.3 Angstrom resolution. Pssm-ID: 461457 Cd Length: 375 Bit Score: 174.14 E-value: 1.90e-50
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