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Conserved domains on  [gi|767942174|ref|XP_011533855|]
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adenylate kinase 9 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 993-1161 8.01e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 8.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1072
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1073 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1149
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942174 1150 QVDDQDIFDRLL 1161
Cdd:cd01428   112 DVPDEVLIERIL 123
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 33-276 1.16e-20

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 91.91  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 112
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  113 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 191
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  192 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 271
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942174  272 PAEEL 276
Cdd:cd01428   190 DIDEV 194
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 1413-1540 9.36e-20

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 89.22  E-value: 9.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:cd01428     1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942174 1493 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1540
Cdd:cd01428    74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 930-985 7.70e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942174  930 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 985
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 993-1161 8.01e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 8.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1072
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1073 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1149
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942174 1150 QVDDQDIFDRLL 1161
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 33-276 1.16e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.91  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 112
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  113 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 191
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  192 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 271
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942174  272 PAEEL 276
Cdd:cd01428   190 DIDEV 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1413-1540 9.36e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 89.22  E-value: 9.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:cd01428     1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942174 1493 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1540
Cdd:cd01428    74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 33-277 2.31e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.87  E-value: 2.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   33 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  107 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPevienh 184
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPP------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  185 rkkKKEAQKDGKGEEeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 262
Cdd:COG0563   145 ---KVEGVCDKCGGE--------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 767942174  263 yLIELNGNKPAEELF 277
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
35-180 5.45e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 5.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174    35 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 114
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767942174   115 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 180
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1413-1540 1.74e-16

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 79.97  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1413 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQ-----AKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 767942174  1493 SVCNTAGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1540
Cdd:TIGR01351   74 NDDNENGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
PLN02842 PLN02842
nucleotide kinase
 37-277 5.92e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 82.99  E-value: 5.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   37 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 116
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  117 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 196
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  197 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 273
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 767942174  274 EELF 277
Cdd:PLN02842  190 EVVF 193
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1413-1540 2.46e-14

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 74.01  E-value: 2.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:COG0563     2 RIILLGPPGAGKGT-----QAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942174 1493 SVCnTAGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1540
Cdd:COG0563    75 PDC-ANGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
AAA_17 pfam13207
AAA domain;
1417-1544 2.17e-13

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 68.81  E-value: 2.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1417 VGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCN 1496
Cdd:pfam13207    1 TGVPGSGKTTQ-----LKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767942174  1497 TAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1544
Cdd:pfam13207   71 EGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 1413-1540 3.10e-13

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 70.95  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:PRK00279    2 RLILLGPPGAGKGT-----QAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767942174 1493 SVCNTaGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1540
Cdd:PRK00279   75 PDCKN-GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 993-1161 4.67e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.07  E-value: 4.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1072
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1073 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1148
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942174 1149 IQVDDQDIFDRLL 1161
Cdd:COG0563   113 LDVDDEELVERLS 125
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 930-985 7.70e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942174  930 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 985
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 993-1161 1.15e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.16  E-value: 1.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1072
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1073 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1151
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942174  1152 DDQDIFDRLL 1161
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 993-1161 8.14e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.29  E-value: 8.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1072
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1073 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1145
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942174 1146 AVFIQVDDQDIFDRLL 1161
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
997-1161 1.05e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 49.93  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   997 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1075
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1076 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1149
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942174  1150 QVDDQDIFDRLL 1161
Cdd:pfam13207  109 EADPEEILERRL 120
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 935-983 6.35e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 6.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942174   935 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 983
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 993-1161 8.01e-23

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 98.08  E-value: 8.01e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1072
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1073 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1149
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942174 1150 QVDDQDIFDRLL 1161
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 33-276 1.16e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 91.91  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 112
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  113 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 191
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  192 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 271
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942174  272 PAEEL 276
Cdd:cd01428   190 DIDEV 194
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1413-1540 9.36e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 89.22  E-value: 9.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:cd01428     1 RILLLGPPGSGKGTQ-----AERLAKKYGLPHISTGDLLREEIAS--GTELGKKAKEYIDSGKLVPDEIVIKLLKERLKK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942174 1493 SVCNTaGVVIDGYPVTKHQMNLLE---ARSIIPMVIFELSVPSKEIFKRLL 1540
Cdd:cd01428    74 PDCKK-GFILDGFPRTVDQAEALDellDEGIKPDKVIELDVPDEVLIERIL 123
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 33-277 2.31e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 82.87  E-value: 2.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   33 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  107 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPevienh 184
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPP------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  185 rkkKKEAQKDGKGEEeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 262
Cdd:COG0563   145 ---KVEGVCDKCGGE--------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 767942174  263 yLIELNGNKPAEELF 277
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
35-180 5.45e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.82  E-value: 5.45e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174    35 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 114
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767942174   115 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 180
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1413-1540 1.74e-16

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 79.97  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1413 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQ-----AKRIAEKYGLPHISTGDLLRAEIKA--GTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQ 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 767942174  1493 SVCNTAGVVIDGYPVTKHQMNLLEARSIIPM-VIFELSVPSKEIFKRLL 1540
Cdd:TIGR01351   74 NDDNENGFILDGFPRTLSQAEALDALLEEPIdAVIELDVPDEELVERLS 122
PLN02842 PLN02842
nucleotide kinase
 37-277 5.92e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 82.99  E-value: 5.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   37 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 116
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  117 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 196
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  197 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 273
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 767942174  274 EELF 277
Cdd:PLN02842  190 EVVF 193
adk PRK00279
adenylate kinase; Reviewed
 33-180 2.12e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 77.11  E-value: 2.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   33 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:PRK00279    3 LILLGPPGAGKGTQAKFIAEKYG------IPhistgdMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767942174  107 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 180
Cdd:PRK00279   77 -CKNGFLLDGFPrTIPQaEALD-----EMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKV 146
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 27-172 1.40e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 75.22  E-value: 1.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   27 LSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 106
Cdd:PTZ00088    3 LKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767942174  107 VCHF-GYIITEIPSlsqdamTTLQQIELIKNLNlkPDVIINIKCPDYDLCQRISGQRQHNNTGYIYS 172
Cdd:PTZ00088   83 DDCFkGFILDGFPR------NLKQCKELGKITN--IDLFVNIYLPRNILIKKLLGRRICNTCNRNFN 141
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1413-1540 2.46e-14

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 74.01  E-value: 2.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:COG0563     2 RIILLGPPGAGKGT-----QAKRLAEKYGIPHISTGDMLRAAVKA--GTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942174 1493 SVCnTAGVVIDGYPVTKHQM----NLLEARSIIPMVIFELSVPSKEIFKRLL 1540
Cdd:COG0563    75 PDC-ANGFILDGFPRTVAQAealdELLAELGIKLDAVIELDVDDEELVERLS 125
AAA_17 pfam13207
AAA domain;
1417-1544 2.17e-13

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 68.81  E-value: 2.17e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1417 VGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhpETELALMLNwHLHKGMTAPDELAIQALELSLMESvCN 1496
Cdd:pfam13207    1 TGVPGSGKTTQ-----LKKLAEKLGFPHISAGDLLREEAK---ERGLVEDRD-EMRKLPLEPQKELQKLAAERIAEE-AG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 767942174  1497 TAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSVPSKEIFKRLLLEKE 1544
Cdd:pfam13207   71 EGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKDRT 124
adk PRK00279
adenylate kinase; Reviewed
 1413-1540 3.10e-13

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 70.95  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:PRK00279    2 RLILLGPPGAGKGT-----QAKFIAEKYGIPHISTGDMLRAAVKA--GTELGKEAKSYMDAGELVPDEIVIGLVKERLAQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767942174 1493 SVCNTaGVVIDGYPVTKHQM----NLLEARSI-IPMVIfELSVPSKEIFKRLL 1540
Cdd:PRK00279   75 PDCKN-GFLLDGFPRTIPQAealdEMLKELGIkLDAVI-EIDVPDEELVERLS 125
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 993-1161 4.67e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 67.07  E-value: 4.67e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1072
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1073 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1148
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942174 1149 IQVDDQDIFDRLL 1161
Cdd:COG0563   113 LDVDDEELVERLS 125
ADK pfam00406
Adenylate kinase;
1416-1540 4.13e-10

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 60.79  E-value: 4.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1416 IVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESVC 1495
Cdd:pfam00406    1 LLGPPGAGKGTQ-----AEKIVQKYGLPHLSTGDLLRAEIKS--GTELGKEAKEYMDKGELVPDEVVVGLVKERLEQNDC 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 767942174  1496 NTaGVVIDGYPVTKHQMNLLEA--RSIIPM-VIFELSVPSKEIFKRLL 1540
Cdd:pfam00406   74 KN-GFLLDGFPRTVPQAEALEEllERGIKLdYVIEFDVPDEVLVERLT 120
PRK14528 PRK14528
adenylate kinase; Provisional
 1413-1548 1.05e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 60.03  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:PRK14528    3 NIIFMGPPGAGKGT-----QAKILCERLSIPQISTGDILREAVKN--QTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIRE 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767942174 1493 SVCNTaGVVIDGYPVTKHQMNLLEA------RSIIPMVifELSVPSKEIFKRLLLEKENEQR 1548
Cdd:PRK14528   76 ADCKN-GFLLDGFPRTVEQADALDAllknegKSIDKAI--NLEVPDGELLKRLLGRAEIEGR 134
PRK14528 PRK14528
adenylate kinase; Provisional
 34-197 1.35e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 59.64  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   34 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYI 113
Cdd:PRK14528    5 IFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREAD-CKNGFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  114 ITEIPSLSQDAMTTlqqIELIKNLNLKPDVIINIKCPDYDLCQRISGQ-----RQHNNTGYIYSR-DQWDPE---VIENH 184
Cdd:PRK14528   84 LDGFPRTVEQADAL---DALLKNEGKSIDKAINLEVPDGELLKRLLGRaeiegRADDNEATIKNRlDNYNKKtlpLLDFY 160

                         170
                  ....*....|...
gi 767942174  185 RKKKKEAQKDGKG 197
Cdd:PRK14528  161 AAQKKLSQVNGVG 173
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 1410-1540 1.86e-09

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 59.06  E-value: 1.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1410 VPIrIIIVGPPKSGKTTvLCfsvaKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELS 1489
Cdd:TIGR01360    3 CKI-IFIVGGPGSGKGT-QC----EKIVEKYGFTHLSTGDLLRAEVAS--GSERGKQLQAIMESGDLVPLDTVLDLLKDA 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942174  1490 LMESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKRLL 1540
Cdd:TIGR01360   75 MVAALGTSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLL 125
adk PRK02496
adenylate kinase; Provisional
 34-195 2.55e-09

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 58.61  E-value: 2.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   34 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 113
Cdd:PRK02496    5 IFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN-GWI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  114 ITEIP-SLSQDAmtTLQqiELIKNLNLKPDVIINIKCPDYDLCQRISGQ-RQHNNTGYIYSR-----DQWDPeVIENHRK 186
Cdd:PRK02496   84 LDGFPrKVTQAA--FLD--ELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDTEEVIRRRlevyrEQTAP-LIDYYRD 158


                  ....*....
gi 767942174  187 KKKEAQKDG 195
Cdd:PRK02496  159 RQKLLTIDG 167
PRK14527 PRK14527
adenylate kinase; Provisional
 1409-1606 2.74e-09

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 58.65  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1409 TVPIRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALR-YVLNNhpeTELALMLNWHLHKGMTAPDELAIQAL- 1486
Cdd:PRK14527    4 TKNKVVIFLGPPGAGKGT-----QAERLAQELGLKKLSTGDILRdHVARG---TELGQRAKPIMEAGDLVPDELILALIr 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1487 -ELSLMESVcntaGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRLPyplHNSAQIVA 1561
Cdd:PRK14527   76 dELAGMEPV----RVIFDGFPRTLAQAEaldrLLEELGARLLAVVLLEVPDEELIRRIVERARQEGRSD---DNEETVRR 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 767942174 1562 VNNVkYRKNIGEIRQYYQEQHQnWYVIDGFHSKWWVWNEVIKNVQ 1606
Cdd:PRK14527  149 RQQV-YREQTQPLVDYYEARGH-LKRVDGLGTPDEVYARILKALG 191
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 930-985 7.70e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.47  E-value: 7.70e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942174  930 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 985
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
PRK14530 PRK14530
adenylate kinase; Provisional
 1413-1539 1.10e-07

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 54.41  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALR---YVLNNHPETELALMLNWhLHKGMTAPDELAIQALEls 1489
Cdd:PRK14530    5 RILLLGAPGAGKGTQ-----SSNLAEEFGVEHVTTGDALRankQMDISDMDTEYDTPGEY-MDAGELVPDAVVNEIVE-- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767942174 1490 lmESVCNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFeLSVPSKEIFKRL 1539
Cdd:PRK14530   77 --EALSDADGFVLDGYPRNLEQAEYLESITDLDVVLY-LDVSEEELVDRL 123
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 993-1161 1.15e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 54.16  E-value: 1.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1072
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1073 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1151
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942174  1152 DDQDIFDRLL 1161
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 993-1161 8.14e-07

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 51.29  E-value: 8.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  993 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1072
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1073 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1145
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942174 1146 AVFIQVDDQDIFDRLL 1161
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
997-1161 1.05e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 49.93  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   997 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1075
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1076 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1149
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942174  1150 QVDDQDIFDRLL 1161
Cdd:pfam13207  109 EADPEEILERRL 120
PRK14532 PRK14532
adenylate kinase; Provisional
 1414-1581 1.15e-06

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 50.98  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1414 IIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNHpeTELALMLNWHLHKGMTAPDELAIQALELSLMES 1493
Cdd:PRK14532    3 LILFGPPAAGKGT-----QAKRLVEERGMVQLSTGDMLRAAIASG--SELGQRVKGIMDRGELVSDEIVIALIEERLPEA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1494 VcNTAGVVIDGYPVTKHQMN----LLEARSIIPMVIFELSVPSKEIFKRLLLEKENEQRlpyPLHNSAQIVaVNNVKYRK 1569
Cdd:PRK14532   76 E-AAGGAIFDGFPRTVAQAEaldkMLASRGQKIDVVIRLKVDDEALIERIVKRFEEQGR---PDDNPEVFV-TRLDAYNA 150

                         170
                  ....*....|..
gi 767942174 1570 NIGEIRQYYQEQ 1581
Cdd:PRK14532  151 QTAPLLPYYAGQ 162
adk PRK02496
adenylate kinase; Provisional
 1412-1590 2.25e-06

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 50.13  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1412 IRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLM 1491
Cdd:PRK02496    2 TRLIFLGPPGAGKGT-----QAVVLAEHLHIPHISTGDILRQAIKE--QTPLGIKAQGYMDKGELVPDQLVLDLVQERLQ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1492 ESvcNTA-GVVIDGYPVTKHQMNLLE------ARSIIPMVifELSVPSKEIFKRLLL---EKENEQrlpyPLHNSAQIva 1561
Cdd:PRK02496   75 QP--DAAnGWILDGFPRKVTQAAFLDellqeiGQSGERVV--NLDVPDDVVVERLLArgrKDDTEE----VIRRRLEV-- 144

                         170       180
                  ....*....|....*....|....*....
gi 767942174 1562 vnnvkYRKNIGEIRQYYQEQHQnWYVIDG 1590
Cdd:PRK02496  145 -----YREQTAPLIDYYRDRQK-LLTIDG 167
ADK pfam00406
Adenylate kinase;
996-1161 7.65e-06

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 48.46  E-value: 7.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   996 LVGPQGSGK-TMCGRqLAEKLNIFHIQFEEVLQEklllktekkvgpefeedsenEQAAKQELEELAiqanvkveeentKK 1074
Cdd:pfam00406    1 LLGPPGAGKgTQAEK-IVQKYGLPHLSTGDLLRA--------------------EIKSGTELGKEA------------KE 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1075 QLPEVQLTEEEEVIKssLMENEplppeilevilsewwLKEPIRSTGFILDGFPRYPEEAQFLGD---RGFFPDAAVFIQV 1151
Cdd:pfam00406   48 YMDKGELVPDEVVVG--LVKER---------------LEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFDV 110

                          170
                   ....*....|
gi 767942174  1152 DDQDIFDRLL 1161
Cdd:pfam00406  111 PDEVLVERLT 120
PLN02842 PLN02842
nucleotide kinase
 1415-1538 1.66e-05

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 49.86  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1415 IIVGPPKSGKTTvLCFSVAKKitseYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSLMESV 1494
Cdd:PLN02842    1 MISGAPASGKGT-QCELIVHK----FGLVHISTGDLLRAEVSA--GTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSRED 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767942174 1495 CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIFELSVPSKEIFKR 1538
Cdd:PLN02842   74 AKEKGWLLDGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDR 117
adk PRK00279
adenylate kinase; Reviewed
 992-1161 2.24e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.45  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  992 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqaakqeleelaiqANVKVEEEN 1071
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR-----------------------------------AAVKAGTEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1072 TKKqlpevqlteeeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQ----FLGDRGFFPDAAV 1147
Cdd:PRK00279   46 GKE-------------AKSYMDAGELVPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVI 111

                         170
                  ....*....|....
gi 767942174 1148 FIQVDDQDIFDRLL 1161
Cdd:PRK00279  112 EIDVPDEELVERLS 125
PLN02200 PLN02200
adenylate kinase family protein
 30-163 7.79e-05

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 46.04  E-value: 7.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   30 PVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCH 109
Cdd:PLN02200   43 PFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767942174  110 FgyIITEIPSlsqdamTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQ 163
Cdd:PLN02200  123 F--LIDGFPR------TEENRIAFERIIGAEPNVVLFFDCPEEEMVKRVLNRNQ 168
PLN02674 PLN02674
adenylate kinase
 1413-1516 1.01e-04

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 46.03  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGMTAPDELAIQALELSLME 1492
Cdd:PLN02674   33 RLILIGPPGSGKGT-----QSPIIKDEYCLCHLATGDMLRAAVA--AKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKK 105

                          90       100
                  ....*....|....*....|....
gi 767942174 1493 SVCNTaGVVIDGYPVTKHQMNLLE 1516
Cdd:PLN02674  106 PSCQK-GFILDGFPRTVVQAQKLD 128
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1411-1540 1.65e-04

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 45.18  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1411 PIRIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALRYVLNNhpETELALMLNWHLHKGMTAPDELAIQALELSL 1490
Cdd:PTZ00088    6 PLKIVLFGAPGVGKGT-----FAEILSKKENLKHINMGNILREEIKA--KTTIGKEIQKVVTSGNLVPDNLVIAIVKDEI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767942174 1491 MESV-CNTAGVVIDGYPVTKHQMNLLEARSIIPMVIfELSVPSKEIFKRLL 1540
Cdd:PTZ00088   79 AKVTdDCFKGFILDGFPRNLKQCKELGKITNIDLFV-NIYLPRNILIKKLL 128
PRK14531 PRK14531
adenylate kinase; Provisional
 1413-1540 1.79e-04

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 44.42  E-value: 1.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174 1413 RIIIVGPPKSGKTTVlcfsvAKKITSEYGLKHLSIGGALRYVLNnhPETELALMLNWHLHKGmtapdELAIQALELSLME 1492
Cdd:PRK14531    4 RLLFLGPPGAGKGTQ-----AARLCAAHGLRHLSTGDLLRSEVA--AGSALGQEAEAVMNRG-----ELVSDALVLAIVE 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767942174 1493 S---VCNTAGVVIDGYPVTKHQMNLLEA------RSIIPMVIFELSvpSKEIFKRLL 1540
Cdd:PRK14531   72 SqlkALNSGGWLLDGFPRTVAQAEALEPlleelkQPIEAVVLLELD--DAVLIERLL 126
PRK13808 PRK13808
adenylate kinase; Provisional
 34-158 1.86e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 45.65  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   34 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 113
Cdd:PRK13808    4 ILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-GFI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767942174  114 ITEIPSlsqdamtTLQQIE----LIKNLNLKPDVIINIKCPDYDLCQRI 158
Cdd:PRK13808   83 LDGFPR-------TVPQAEaldaLLKDKQLKLDAVVELRVNEGALLARV 124
AAA_18 pfam13238
AAA domain;
994-1067 4.08e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 42.03  E-value: 4.08e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942174   994 ICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKV 1067
Cdd:pfam13238    1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGN 74
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 968-1038 5.76e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 44.52  E-value: 5.76e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767942174  968 EAKEKFLEHPEDYVAHEEPlkaPPLRICLVGPQGSGKTMCGRQLAEKL--NIFHIQFEEVLQeKLLLKTEKKV 1038
Cdd:COG0464   171 ELVALPLKRPELREEYGLP---PPRGLLLYGPPGTGKTLLARALAGELglPLIEVDLSDLVS-KYVGETEKNL 239
AAA_17 pfam13207
AAA domain;
36-157 6.39e-04

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 41.84  E-value: 6.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174    36 FGKPGVGKTTLARYITQAWKcirveaLPILE--EQIAAETESG--VMLQSMLISGQSIPDELVIKLMLEKLNSpEVCHFG 111
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLG------FPHISagDLLREEAKERglVEDRDEMRKLPLEPQKELQKLAAERIAE-EAGEGG 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 767942174   112 YIITEIPS-LSQDAMTTLQQIELIKnlNLKPDVIINIKCPDYDLCQR 157
Cdd:pfam13207   74 VIVDGHPRiKTPAGYLPGLPVEVLR--ELKPDAIILLEADPEEILER 118
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 1414-1548 6.41e-04

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 42.74  E-value: 6.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1414 IIIVGPPKSGKTTVlCfsvaKKITSEYGLKHLSIGGALRYVLNNHPETELALMLNwHLHKGMTAPDELAIQALElSLMES 1493
Cdd:TIGR01359    2 VFVLGGPGSGKGTQ-C----AKIVENFGFTHLSAGDLLRAEIKREGSENGSLIES-YIKEGKIVPSEVTVELLK-KAIQE 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  1494 VCNTAGVVIDGYPvtKHQMNL-----LEARSIIPMVIFELSVPSKEIFKRLLLEKENEQR 1548
Cdd:TIGR01359   75 DGSSKKFLIDGFP--RNEENLeawekLMDNKVNFKFVLFFDCPEETMIKRLLKRGQTSGR 132
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 1414-1452 6.78e-04

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 42.41  E-value: 6.78e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767942174  1414 IIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGGALR 1452
Cdd:TIGR02173    3 ITISGPPGSGKTT-----VAKILAEKLSLKLISAGDIFR 36
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 990-1044 8.16e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.88  E-value: 8.16e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767942174  990 PPLRICLVGPQGSGKTMCGRQLAEKLNI--FHIQFEEvLQEKLLLKTEKKVGPEFEE 1044
Cdd:cd19481    25 LPKGILLYGPPGTGKTLLAKALAGELGLplIVVKLSS-LLSKYVGESEKNLRKIFER 80
PRK04182 PRK04182
cytidylate kinase; Provisional
 1413-1448 2.04e-03

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 41.33  E-value: 2.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIG 1448
Cdd:PRK04182    2 IITISGPPGSGKTT-----VARLLAEKLGLKHVSAG 32
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
966-1030 2.43e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 41.79  E-value: 2.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  966 SAEAKEKFLEHPEDYVAHEEPLK---APPLRICLVGPQGSGKTMCGRQLAEKLN--IFHIQFEEVLQEKL 1030
Cdd:COG1223     7 QEEAKKKLKLIIKELRRRENLRKfglWPPRKILFYGPPGTGKTMLAEALAGELKlpLLTVRLDSLIGSYL 76
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
992-1110 3.36e-03

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 42.20  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174  992 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllKTEKKVGPEFEEDSEN--EQAAKQELEELAIQANVKV-- 1067
Cdd:PRK13951    1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIER----REGRSVRRIFEEDGEEyfRLKEKELLRELVERDNVVVat 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942174 1068 --------EEENTKKQLPEVQLTEEEEVIKSSL-MENEPLPPEILEVILSEW 1110
Cdd:PRK13951   77 gggvvidpENRELLKKEKTLFLYAPPEVLMERVtTENRPLLREGKERIREIW 128
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 935-983 6.35e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 6.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942174   935 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 983
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
PRK14526 PRK14526
adenylate kinase; Provisional
 33-172 7.83e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 39.83  E-value: 7.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942174   33 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVcHFGY 112
Cdd:PRK14526    3 LVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDNF 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942174  113 IITEIPSlsqdamTTLQQIELIKNL-NLKpdvIINIKCPDYDLCQRISGQRQHNNTGYIYS 172
Cdd:PRK14526   82 ILDGFPR------NINQAKALDKFLpNIK---IINFLIDEELLIKRLSGRRICKSCNNIFN 133
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 1413-1449 8.79e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 38.62  E-value: 8.79e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767942174 1413 RIIIVGPPKSGKTTvlcfsVAKKITSEYGLKHLSIGG 1449
Cdd:cd02020     1 IIAIDGPAGSGKST-----VAKLLAKKLGLPYLDTGG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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