NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767942182|ref|XP_011533858|]
View 

adenylate kinase 9 isoform X11 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1065-1233 1.24e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


:

Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 96.92  E-value: 1.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1144
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1145 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1221
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942182 1222 QVDDQDIFDRLL 1233
Cdd:cd01428   112 DVPDEVLIERIL 123
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 105-348 1.99e-20

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member cd01428:

Pssm-ID: 450170 [Multi-domain]  Cd Length: 194  Bit Score: 90.76  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942182  344 PAEEL 348
Cdd:cd01428   190 DIDEV 194
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 1002-1057 5.23e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


:

Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.86  E-value: 5.23e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942182 1002 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 1057
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1065-1233 1.24e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 96.92  E-value: 1.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1144
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1145 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1221
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942182 1222 QVDDQDIFDRLL 1233
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 105-348 1.99e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 90.76  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942182  344 PAEEL 348
Cdd:cd01428   190 DIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 105-349 4.01e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 81.71  E-value: 4.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPevienh 256
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPP------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  257 rkkKKEAQKDGKGEEeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 334
Cdd:COG0563   145 ---KVEGVCDKCGGE--------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 767942182  335 yLIELNGNKPAEELF 349
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
107-252 6.98e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.05  E-value: 6.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182   107 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 186
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767942182   187 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
PLN02842 PLN02842
nucleotide kinase
 109-349 4.99e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 82.99  E-value: 4.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  109 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 188
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  189 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 268
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  269 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 345
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 767942182  346 EELF 349
Cdd:PLN02842  190 EVVF 193
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1065-1233 6.08e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 66.69  E-value: 6.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1144
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1145 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1220
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942182 1221 IQVDDQDIFDRLL 1233
Cdd:COG0563   113 LDVDDEELVERLS 125
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 1002-1057 5.23e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.86  E-value: 5.23e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942182 1002 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 1057
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1065-1233 1.13e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 53.78  E-value: 1.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1144
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1145 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1223
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942182  1224 DDQDIFDRLL 1233
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 1065-1233 1.17e-06

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 50.52  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1144
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1145 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1217
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942182 1218 AVFIQVDDQDIFDRLL 1233
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
1069-1233 2.65e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 48.39  E-value: 2.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1069 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1147
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1148 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1221
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942182  1222 QVDDQDIFDRLL 1233
Cdd:pfam13207  109 EADPEEILERRL 120
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 1007-1055 5.04e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 5.04e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942182  1007 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 1055
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
 
Name Accession Description Interval E-value
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 1065-1233 1.24e-22

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 96.92  E-value: 1.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEkkvgpefeedseneqaakqeleelaiqanvkveeent 1144
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTE------------------------------------- 43

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1145 kkqlpevqLTEEeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQFL---GDRGFFPDAAVFI 1221
Cdd:cd01428    44 --------LGKK---AKEYIDSGKLVPDEIVIKLLKER-LKKPDCKKGFILDGFPRTVDQAEALdelLDEGIKPDKVIEL 111

                         170
                  ....*....|..
gi 767942182 1222 QVDDQDIFDRLL 1233
Cdd:cd01428   112 DVPDEVLIERIL 123
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 105-348 1.99e-20

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 90.76  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGY 184
Cdd:cd01428     2 ILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKGF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  185 IITEIP-SLSQdamttLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYsrdqwdpevienHRKKKKEA 263
Cdd:cd01428    81 ILDGFPrTVDQ-----AEALDELLDEGIKPDKVIELDVPDEVLIERILGRRICPVSGRVY------------HLGKDDVT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  264 QKDgkgeeeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKETILQTLEEVMaehNPQYLIELNGNK 343
Cdd:cd01428   144 GEP-------------------------------LSQRSDDNEETIKKRLEVYKEQTAPLIDYYK---KKGKLVEIDGSG 189


                  ....*
gi 767942182  344 PAEEL 348
Cdd:cd01428   190 DIDEV 194
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 105-349 4.01e-17

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 81.71  E-value: 4.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:COG0563     3 IILLGPPGAGKGTQAKRLAEKYG------IPhistgdMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPevienh 256
Cdd:COG0563    77 -CANGFILDGFPrTVAQaEALD-----ELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPP------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  257 rkkKKEAQKDGKGEEeeeeeeqeeeeafiaemqmvaeilhhLVQRPEDYLENVENIVKLYKEtilQT--LEEVMAEHNPq 334
Cdd:COG0563   145 ---KVEGVCDKCGGE--------------------------LVQRADDNEETVRKRLEVYHE---QTapLIDYYRKKGK- 191

                         250
                  ....*....|....*
gi 767942182  335 yLIELNGNKPAEELF 349
Cdd:COG0563   192 -LVEIDGEGSIEEVT 205
ADK pfam00406
Adenylate kinase;
107-252 6.98e-17

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 80.05  E-value: 6.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182   107 VFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYII 186
Cdd:pfam00406    1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQND-CKNGFLL 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767942182   187 TEIP-SLSQ-DAMTTLQQieliknLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:pfam00406   80 DGFPrTVPQaEALEELLE------RGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKV 141
PLN02842 PLN02842
nucleotide kinase
 109-349 4.99e-16

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 82.99  E-value: 4.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  109 GKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHFGYIITE 188
Cdd:PLN02842    4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  189 IPSlsqdamtTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEvienhrkkkkeaqkdgk 268
Cdd:PLN02842   84 YPR-------SFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----------------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  269 geeeeeeeeqeeeeafiaemqmVAEILHHLVQRPEDYLENVENIVKLYK---ETILQTLEEVMaehnpqylIELNGNKPA 345
Cdd:PLN02842  140 ----------------------SEEIKARLITRPDDTEEKVKARLQIYKknaEAILSTYSDIM--------VKIDGNRPK 189


                  ....
gi 767942182  346 EELF 349
Cdd:PLN02842  190 EVVF 193
adk PRK00279
adenylate kinase; Reviewed
 105-252 2.87e-15

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 76.34  E-value: 2.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKcirveaLP------ILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:PRK00279    3 LILLGPPGAGKGTQAKFIAEKYG------IPhistgdMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQPD 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767942182  179 vCHFGYIITEIP-SLSQ-DAMTtlqqiELIKNLNLKPDVIINIKCPDYDLCQRISGQRQHNNTGYIYSRDQWDPEV 252
Cdd:PRK00279   77 -CKNGFLLDGFPrTIPQaEALD-----EMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKV 146
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 99-244 1.04e-14

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 75.22  E-value: 1.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182   99 LSKPVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:PTZ00088    3 LKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767942182  179 VCHF-GYIITEIPSlsqdamTTLQQIELIKNLNlkPDVIINIKCPDYDLCQRISGQRQHNNTGYIYS 244
Cdd:PTZ00088   83 DDCFkGFILDGFPR------NLKQCKELGKITN--IDLFVNIYLPRNILIKKLLGRRICNTCNRNFN 141
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 1065-1233 6.08e-12

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 66.69  E-value: 6.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQAnvkveeent 1144
Cdd:COG0563     2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLR-----------------------AAVKAGTELGKKA--------- 49

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1145 kkqlpevqlteeEEVIKSSLMenepLPPEILEVILsEWWLKEPIRSTGFILDGFPRYPEEAQFL----GDRGFFPDAAVF 1220
Cdd:COG0563    50 ------------KEYMDAGEL----VPDEIVIGLV-KERLAQPDCANGFILDGFPRTVAQAEALdellAELGIKLDAVIE 112

                         170
                  ....*....|...
gi 767942182 1221 IQVDDQDIFDRLL 1233
Cdd:COG0563   113 LDVDDEELVERLS 125
PRK14528 PRK14528
adenylate kinase; Provisional
 106-269 1.60e-09

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 58.87  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEvCHFGYI 185
Cdd:PRK14528    5 IFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREAD-CKNGFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  186 ITEIPSLSQDAMTTlqqIELIKNLNLKPDVIINIKCPDYDLCQRISGQ-----RQHNNTGYIYSR-DQWDPE---VIENH 256
Cdd:PRK14528   84 LDGFPRTVEQADAL---DALLKNEGKSIDKAINLEVPDGELLKRLLGRaeiegRADDNEATIKNRlDNYNKKtlpLLDFY 160

                         170
                  ....*....|...
gi 767942182  257 RKKKKEAQKDGKG 269
Cdd:PRK14528  161 AAQKKLSQVNGVG 173
adk PRK02496
adenylate kinase; Provisional
 106-267 3.64e-09

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 57.84  E-value: 3.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 185
Cdd:PRK02496    5 IFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAAN-GWI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  186 ITEIP-SLSQDAmtTLQqiELIKNLNLKPDVIINIKCPDYDLCQRISGQ-RQHNNTGYIYSR-----DQWDPeVIENHRK 258
Cdd:PRK02496   84 LDGFPrKVTQAA--FLD--ELLQEIGQSGERVVNLDVPDDVVVERLLARgRKDDTEEVIRRRlevyrEQTAP-LIDYYRD 158


                  ....*....
gi 767942182  259 KKKEAQKDG 267
Cdd:PRK02496  159 RQKLLTIDG 167
YHS COG3350
Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport ...
 1002-1057 5.23e-08

Heavy metal-bindng TRASH/YHS domain, predicted Cu/Ag metallochaperone [Inorganic ion transport and metabolism];


Pssm-ID: 442578  Cd Length: 56  Bit Score: 50.86  E-value: 5.23e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767942182 1002 GDTKHFCPVVLKEnfiLQPGNTEEAAKYREKIYYFSSAEAKEKFLEHPEDYVAHEE 1057
Cdd:COG3350     3 GVAMVIDPVCGMT---VDPGSAAYTAEYDGKTYYFCSEECRDKFKANPEKYLPQYG 55
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 1065-1233 1.13e-07

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 53.78  E-value: 1.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllktekkvgpEFEEDSENEQAAKQELEelaiqanvkveeent 1144
Cdd:TIGR01351    1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRA------------EIKAGTPLGKKAKEYME--------------- 53

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1145 KKQLpevqlteeeeviksslmenepLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFLGDRGFFP-DAAVFIQV 1223
Cdd:TIGR01351   54 KGEL---------------------VPDEIVNQLVKERLTQNDDNENGFILDGFPRTLSQAEALDALLEEPiDAVIELDV 112

                          170
                   ....*....|
gi 767942182  1224 DDQDIFDRLL 1233
Cdd:TIGR01351  113 PDEELVERLS 122
adk PRK02496
adenylate kinase; Provisional
 1065-1233 1.17e-06

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 50.52  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1065 RICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqAAKQELEELAIQANvkveeent 1144
Cdd:PRK02496    3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILR-----------------------QAIKEQTPLGIKAQ-------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1145 kkqlpevqlteeeeviksSLMENEPLPPEILEVILSEWWLKEPIRSTGFILDGFPRYPEEAQFL-------GDRGffpDA 1217
Cdd:PRK02496   52 ------------------GYMDKGELVPDQLVLDLVQERLQQPDAANGWILDGFPRKVTQAAFLdellqeiGQSG---ER 110

                         170
                  ....*....|....*.
gi 767942182 1218 AVFIQVDDQDIFDRLL 1233
Cdd:PRK02496  111 VVNLDVPDDVVVERLL 126
AAA_17 pfam13207
AAA domain;
1069-1233 2.65e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 48.39  E-value: 2.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1069 VGPQGSGK-TMCgRQLAEKLNIFHIQFEEVLqeklllktekkvgpeFEEdseneqAAKQELEElaiqanvkveeenTKKQ 1147
Cdd:pfam13207    1 TGVPGSGKtTQL-KKLAEKLGFPHISAGDLL---------------REE------AKERGLVE-------------DRDE 45

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1148 LPEVQLTEEEEVIKsslmeneplppEILEVIlsewwlKEPIRSTGFILDGFPRYPEEAQFLGD------RGFFPDAAVFI 1221
Cdd:pfam13207   46 MRKLPLEPQKELQK-----------LAAERI------AEEAGEGGVIVDGHPRIKTPAGYLPGlpvevlRELKPDAIILL 108

                          170
                   ....*....|..
gi 767942182  1222 QVDDQDIFDRLL 1233
Cdd:pfam13207  109 EADPEEILERRL 120
ADK pfam00406
Adenylate kinase;
1068-1233 9.52e-06

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 47.69  E-value: 9.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1068 LVGPQGSGK-TMCGRqLAEKLNIFHIQFEEVLQEklllktekkvgpefeedsenEQAAKQELEELAiqanvkveeentKK 1146
Cdd:pfam00406    1 LLGPPGAGKgTQAEK-IVQKYGLPHLSTGDLLRA--------------------EIKSGTELGKEA------------KE 47

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  1147 QLPEVQLTEEEEVIKssLMENEplppeilevilsewwLKEPIRSTGFILDGFPRYPEEAQFLGD---RGFFPDAAVFIQV 1223
Cdd:pfam00406   48 YMDKGELVPDEVVVG--LVKER---------------LEQNDCKNGFLLDGFPRTVPQAEALEElleRGIKLDYVIEFDV 110

                          170
                   ....*....|
gi 767942182  1224 DDQDIFDRLL 1233
Cdd:pfam00406  111 PDEVLVERLT 120
adk PRK00279
adenylate kinase; Reviewed
 1064-1233 2.56e-05

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 47.07  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1064 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQeklllktekkvgpefeedseneqaakqeleelaiqANVKVEEEN 1143
Cdd:PRK00279    1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLR-----------------------------------AAVKAGTEL 45

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1144 TKKqlpevqlteeeevIKSSLMENEPLPPEILEVILSEWwLKEPIRSTGFILDGFPRYPEEAQ----FLGDRGFFPDAAV 1219
Cdd:PRK00279   46 GKE-------------AKSYMDAGELVPDEIVIGLVKER-LAQPDCKNGFLLDGFPRTIPQAEaldeMLKELGIKLDAVI 111

                         170
                  ....*....|....
gi 767942182 1220 FIQVDDQDIFDRLL 1233
Cdd:PRK00279  112 EIDVPDEELVERLS 125
PLN02200 PLN02200
adenylate kinase family protein
 102-235 7.03e-05

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 46.04  E-value: 7.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  102 PVCFVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCH 181
Cdd:PLN02200   43 PFITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNK 122

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767942182  182 FgyIITEIPSlsqdamTTLQQIELIKNLNLKPDVIINIKCPDYDLCQRISGQRQ 235
Cdd:PLN02200  123 F--LIDGFPR------TEENRIAFERIIGAEPNVVLFFDCPEEEMVKRVLNRNQ 168
PRK13808 PRK13808
adenylate kinase; Provisional
 106-230 1.56e-04

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 45.65  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  106 VVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVCHfGYI 185
Cdd:PRK13808    4 ILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAAN-GFI 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767942182  186 ITEIPSlsqdamtTLQQIE----LIKNLNLKPDVIINIKCPDYDLCQRI 230
Cdd:PRK13808   83 LDGFPR-------TVPQAEaldaLLKDKQLKLDAVVELRVNEGALLARV 124
AAA_18 pfam13238
AAA domain;
1066-1139 4.19e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 41.65  E-value: 4.19e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942182  1066 ICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEKLLLKTEKKVGPEFEEDSENEQAAKQELEELAIQANVKV 1139
Cdd:pfam13238    1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGN 74
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 1062-1116 6.68e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 41.88  E-value: 6.68e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767942182 1062 PPLRICLVGPQGSGKTMCGRQLAEKLNI--FHIQFEEvLQEKLLLKTEKKVGPEFEE 1116
Cdd:cd19481    25 LPKGILLYGPPGTGKTLLAKALAGELGLplIVVKLSS-LLSKYVGESEKNLRKIFER 80
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 1040-1110 6.80e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 43.75  E-value: 6.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767942182 1040 EAKEKFLEHPEDYVAHEEPlkaPPLRICLVGPQGSGKTMCGRQLAEKL--NIFHIQFEEVLQeKLLLKTEKKV 1110
Cdd:COG0464   171 ELVALPLKRPELREEYGLP---PPRGLLLYGPPGTGKTLLARALAGELglPLIEVDLSDLVS-KYVGETEKNL 239
AAA_17 pfam13207
AAA domain;
108-229 1.16e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 40.69  E-value: 1.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182   108 FGKPGVGKTTLARYITQAWKcirveaLPILE--EQIAAETESG--VMLQSMLISGQSIPDELVIKLMLEKLNSpEVCHFG 183
Cdd:pfam13207    1 TGVPGSGKTTQLKKLAEKLG------FPHISagDLLREEAKERglVEDRDEMRKLPLEPQKELQKLAAERIAE-EAGEGG 73

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 767942182   184 YIITEIPS-LSQDAMTTLQQIELIKnlNLKPDVIINIKCPDYDLCQR 229
Cdd:pfam13207   74 VIVDGHPRiKTPAGYLPGLPVEVLR--ELKPDAIILLEADPEEILER 118
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
1038-1102 2.35e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 41.41  E-value: 2.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1038 SAEAKEKFLEHPEDYVAHEEPLK---APPLRICLVGPQGSGKTMCGRQLAEKLN--IFHIQFEEVLQEKL 1102
Cdd:COG1223     7 QEEAKKKLKLIIKELRRRENLRKfglWPPRKILFYGPPGTGKTMLAEALAGELKlpLLTVRLDSLIGSYL 76
PRK13951 PRK13951
bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;
1064-1182 3.13e-03

bifunctional shikimate kinase AroK/3-dehydroquinate synthase AroB;


Pssm-ID: 172457 [Multi-domain]  Cd Length: 488  Bit Score: 41.81  E-value: 3.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182 1064 LRICLVGPQGSGKTMCGRQLAEKLNIFHIQFEEVLQEklllKTEKKVGPEFEEDSEN--EQAAKQELEELAIQANVKV-- 1139
Cdd:PRK13951    1 MRIFLVGMMGSGKSTIGKRVSEVLDLQFIDMDEEIER----REGRSVRRIFEEDGEEyfRLKEKELLRELVERDNVVVat 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767942182 1140 --------EEENTKKQLPEVQLTEEEEVIKSSL-MENEPLPPEILEVILSEW 1182
Cdd:PRK13951   77 gggvvidpENRELLKKEKTLFLYAPPEVLMERVtTENRPLLREGKERIREIW 128
FAP206 pfam12018
Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There ...
 1007-1055 5.04e-03

Domain of unknown function; This domain of about 280 residues is found in eukaryotes. There are two conserved sequence motifs: GFC and GLL. This family is also known as UPF0704. This domain is found in FAP206, a protein associated with cilia and flagella. In the ciliate Tetrahymena, the cilium has radial spokes, each of which is a macromolecular complex essential for motility. A triplet of three radial spokes, RS1, RS2, and RS3, is repeated every 96 nm along the doublet microtubule. Each spoke has a distinct base that docks to the doublet and is linked to different inner dynein arms. Knockout of the FAP206 gene results in slow cell motility and the 96-nm repeats lack RS2 and dynein c. FAP206 is probably part of the front prong and docks RS2 and dynein c to the microtubule.


Pssm-ID: 463432  Cd Length: 273  Bit Score: 40.71  E-value: 5.04e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767942182  1007 FCPVVL-KENFILQPGNTE-EAAKYREKIYYFSSAEAKEKFLEHPEDYVAH 1055
Cdd:pfam12018  201 FCAWTLvVRDGLLLPGNPSiGVLKYKDKYYAFSSKEAAYEFASDPDRFIAA 251
PRK14526 PRK14526
adenylate kinase; Provisional
 105-244 6.72e-03

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 39.83  E-value: 6.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKCIRVEALPILEEQIAAETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPEVcHFGY 184
Cdd:PRK14526    3 LVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-NDNF 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767942182  185 IITEIPSlsqdamTTLQQIELIKNL-NLKpdvIINIKCPDYDLCQRISGQRQHNNTGYIYS 244
Cdd:PRK14526   82 ILDGFPR------NINQAKALDKFLpNIK---IINFLIDEELLIKRLSGRRICKSCNNIFN 133
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
105-147 7.95e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 38.74  E-value: 7.95e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767942182  105 FVVFGKPGVGKTTLARYITQAWKCIR----VEALPILEEQIAAETES 147
Cdd:COG0645     2 ILVCGLPGSGKSTLARALAERLGAVRlrsdVVRKRLFGAGLAPLERS 48
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 99-217 8.64e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 38.28  E-value: 8.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942182   99 LSKPVCFVVFGKPGVGKTTLARYItqAWKCIRVEAlPILeeqiaaETESGVMLQSMLISGQSIPDELVIKLMLEKLNSPE 178
Cdd:cd00009    16 LPPPKNLLLYGPPGTGKTTLARAI--ANELFRPGA-PFL------YLNASDLLEGLVVAELFGHFLVRLLFELAEKAKPG 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767942182  179 VchfgYIITEIPSLSQDAMTTLQQI--ELIKNLNLKPDVII 217
Cdd:cd00009    87 V----LFIDEIDSLSRGAQNALLRVleTLNDLRIDRENVRV 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH