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Conserved domains on  [gi|767942519|ref|XP_011533999|]
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WD repeat-containing protein 27 isoform X17 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 1.06e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942519 205 WRaGTLISASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200  230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 1.06e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942519 205 WRaGTLISASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200  230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-267 2.37e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319  183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 123 lgkVLCLQLSLDDHVVAVC-AGNKIFMLDIEQRFSVTYIERPDvnnrHKV------PPPTFLHTFSQTQAVR-------- 187
Cdd:COG2319  249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHS----GGVnsvafsPDGKLLASGSDDGTVRlwdlatgk 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 188 --AELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIF 265
Cdd:COG2319  322 llRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLW 399


                 ..
gi 767942519 266 SL 267
Cdd:COG2319  400 DL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-223 3.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767942519   183 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-223 4.50e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767942519  188 AELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWD 223
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-266 1.06e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVEFCP 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDL------------------------------STGKCLGTLRGHENGVNSVAFSP 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767942519 205 WRaGTLISASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200  230 DG-YLLASGSEDGTIRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-267 2.37e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319  183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 123 lgkVLCLQLSLDDHVVAVC-AGNKIFMLDIEQRFSVTYIERPDvnnrHKV------PPPTFLHTFSQTQAVR-------- 187
Cdd:COG2319  249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHS----GGVnsvafsPDGKLLASGSDDGTVRlwdlatgk 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 188 --AELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIF 265
Cdd:COG2319  322 llRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLW 399


                 ..
gi 767942519 266 SL 267
Cdd:COG2319  400 DL 401
WD40 COG2319
WD40 repeat [General function prediction only];
48-270 8.80e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 8.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnpLLIcSASLDYVI-MWNLDECRE-KVLQGLVprgtvmgsl 122
Cdd:COG2319  141 DGT-VRLWDLATGK-LLRTLTGHSGAVTSVAFspdGK----LLA-SGSDDGTVrLWDLATGKLlRTLTGHT--------- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 123 lGKVLCLQLSLDDHVVAVCAGNK-IFMLDIeqrfsvtyierpdvnnrhkvppptflhtfsQTQAVRAELQGHLGPVTAVE 201
Cdd:COG2319  205 -GAVRSVAFSPDGKLLASGSADGtVRLWDL------------------------------ATGKLLRTLTGHSGSVRSVA 253

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767942519 202 FCPWRAgTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 270
Cdd:COG2319  254 FSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-270 2.25e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 2.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  48 DGTeLCIWNTKDPShQLLILRGHHQPIT---AMAFGNKvnpllICSASLDY-VIMWNLdecrekvlQGLVPRGTVMGSLl 123
Cdd:cd00200   30 DGT-IKVWDLETGE-LLRTLKGHTGPVRdvaASADGTY-----LASGSSDKtIRLWDL--------ETGECVRTLTGHT- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 124 GKVLCLQLSLDDHVVAVCAGNK-IFMLDIE---QRFSVTYIERPdVNNRHKVPPPTFLHTFSQTQAVR----------AE 189
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKtIKVWDVEtgkCLTTLRGHTDW-VNSVAFSPDGTFVASSSQDGTIKlwdlrtgkcvAT 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 190 LQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIYS-----SSVLSAypllsLFIDaeSRQLVTGCA-DGQLW 263
Cdd:cd00200  173 LTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTlrgheNGVNSV-----AFSP--DGYLLASGSeDGTIR 244


                 ....*..
gi 767942519 264 IFSLMDG 270
Cdd:cd00200  245 VWDLRTG 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-272 3.93e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.73  E-value: 3.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519  67 LRGHHQPITAMAFGNKVNplLICSASLD-YVIMWNLDECR-EKVLQGlvprgtvmgsLLGKVLCLQLSLDDHVVAVCAGN 144
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGK--LLATGSGDgTIKVWDLETGElLRTLKG----------HTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 145 K-IFMLDIEQRFSVTYIE--RPDVNNRHKVPPPTFL-----------HTFSQTQAVRAeLQGHLGPVTAVEFCPwrAGTL 210
Cdd:cd00200   73 KtIRLWDLETGECVRTLTghTSYVSSVAFSPDGRILssssrdktikvWDVETGKCLTT-LRGHTDWVNSVAFSP--DGTF 149

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767942519 211 I-SASEDRGFKVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFSLMDGHH 272
Cdd:cd00200  150 VaSSSQDGTIKLWDLRTGKCVA---TLTGHtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-271 1.82e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 187 RAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFS 266
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWD 79


                 ....*
gi 767942519 267 LMDGH 271
Cdd:cd00200   80 LETGE 84
WD40 COG2319
WD40 repeat [General function prediction only];
182-270 4.60e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 4.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 182 QTQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQ 261
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGT 185


                 ....*....
gi 767942519 262 LWIFSLMDG 270
Cdd:COG2319  186 VRLWDLATG 194
WD40 COG2319
WD40 repeat [General function prediction only];
181-270 2.97e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 2.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942519 181 SQTQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADG 260
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTG-AVRSVAFSPDGKTLASGSADG 142

                         90
                 ....*....|
gi 767942519 261 QLWIFSLMDG 270
Cdd:COG2319  143 TVRLWDLATG 152
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-223 3.39e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.39e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767942519   183 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
188-223 4.50e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 4.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 767942519  188 AELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWD 223
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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