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Conserved domains on  [gi|767942864|ref|XP_011534135|]
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mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2 [Homo sapiens]

Protein Classification

glycoside hydrolase family 47 protein( domain architecture ID 10479221)

glycoside hydrolase family 47 protein such as ER class I alpha1,2-mannosidase, which is a critical enzyme in the maturation of N-linked oligosaccharides and ER-associated degradation

CATH:  1.50.10.10
CAZY:  GH47
EC:  3.2.1.-
SCOP:  3000996

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_47 pfam01532
Glycosyl hydrolase family 47; Members of this family are alpha-mannosidases that catalyze the ...
13-451 0e+00

Glycosyl hydrolase family 47; Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).


:

Pssm-ID: 460241  Cd Length: 453  Bit Score: 601.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864   13 MMKHAWNNYKGYAWGLNELKPISKGGHSSslFGNIkGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNA-EISVFE 91
Cdd:pfam01532   1 AFLHAWDGYKKYAWGHDELRPISGGGNDT--FGGW-GATIVDSLDTLIIMGLTDEFEEAVDWVEKTLDFDKDStEVSVFE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864   92 VNIRFVGGLLSAYYLS--GEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWAsGGSSILAEFGTLHLEFM 169
Cdd:pfam01532  78 TTIRYLGGLLSAYDLSgdGDDVLLEKAVDLADRLLPAFDTPTGIPYPRVNLKTGKGGNGHVA-GGASSLAEAGTLQLEFT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  170 HLSHLSGNPIFAEKVMNIRTVLNKLE---KPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKK 246
Cdd:pfam01532 157 RLSQLTGDPKYEDLAQKIMDVLWKNQsrtPLPGLVPIYIDPDTGKFVGSNIGLGARGDSYYEYLLKQYLLTGGTDPEYRD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  247 MYFDAVQAIETHLIRKSS--SGLTYIAEWK---GGLLEHKMGHLTCFAGGMFALGADAAPEgmAQHYLELGAEIARTCHE 321
Cdd:pfam01532 237 MYEEAMDAIKKHLLFRPStpSDLLFIGELDsggGGKLSPKMDHLSCFAGGMLALGATLGLP--REGDLELAEKLTEGCYK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  322 SYNRTFMKLGPEAFRFDGGVE---------AIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRV 392
Cdd:pfam01532 315 TYDSTPTGLGPEIFYFDPCDEdcpwdedkwDFYVKIEDPHYLLRPETIESLFYLYRATGDPKYREWGWEIFQAIEKYTRT 394
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767942864  393 NGGYSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPI 451
Cdd:pfam01532 395 ECGYSGLQDVTSPPGEKEDNMESFWLAETLKYLYLLFSDDDLLSLDEWVFNTEAHPLPV 453
 
Name Accession Description Interval E-value
Glyco_hydro_47 pfam01532
Glycosyl hydrolase family 47; Members of this family are alpha-mannosidases that catalyze the ...
13-451 0e+00

Glycosyl hydrolase family 47; Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).


Pssm-ID: 460241  Cd Length: 453  Bit Score: 601.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864   13 MMKHAWNNYKGYAWGLNELKPISKGGHSSslFGNIkGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNA-EISVFE 91
Cdd:pfam01532   1 AFLHAWDGYKKYAWGHDELRPISGGGNDT--FGGW-GATIVDSLDTLIIMGLTDEFEEAVDWVEKTLDFDKDStEVSVFE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864   92 VNIRFVGGLLSAYYLS--GEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWAsGGSSILAEFGTLHLEFM 169
Cdd:pfam01532  78 TTIRYLGGLLSAYDLSgdGDDVLLEKAVDLADRLLPAFDTPTGIPYPRVNLKTGKGGNGHVA-GGASSLAEAGTLQLEFT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  170 HLSHLSGNPIFAEKVMNIRTVLNKLE---KPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKK 246
Cdd:pfam01532 157 RLSQLTGDPKYEDLAQKIMDVLWKNQsrtPLPGLVPIYIDPDTGKFVGSNIGLGARGDSYYEYLLKQYLLTGGTDPEYRD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  247 MYFDAVQAIETHLIRKSS--SGLTYIAEWK---GGLLEHKMGHLTCFAGGMFALGADAAPEgmAQHYLELGAEIARTCHE 321
Cdd:pfam01532 237 MYEEAMDAIKKHLLFRPStpSDLLFIGELDsggGGKLSPKMDHLSCFAGGMLALGATLGLP--REGDLELAEKLTEGCYK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  322 SYNRTFMKLGPEAFRFDGGVE---------AIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRV 392
Cdd:pfam01532 315 TYDSTPTGLGPEIFYFDPCDEdcpwdedkwDFYVKIEDPHYLLRPETIESLFYLYRATGDPKYREWGWEIFQAIEKYTRT 394
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767942864  393 NGGYSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPI 451
Cdd:pfam01532 395 ECGYSGLQDVTSPPGEKEDNMESFWLAETLKYLYLLFSDDDLLSLDEWVFNTEAHPLPV 453
PTZ00470 PTZ00470
glycoside hydrolase family 47 protein; Provisional
13-455 0e+00

glycoside hydrolase family 47 protein; Provisional


Pssm-ID: 240427  Cd Length: 522  Bit Score: 575.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  13 MMKHAWNNYKGYAWGLNELKPISKGGHSSslFGniKGATIVDALDTLFIMEMKHEFEEAKSWVEENL--DFNVNAEISVF 90
Cdd:PTZ00470  79 AMKHAWEGYKEYAWGHDELRPLTKRHHEW--FG--LGLTIIDSLDTLKIMGLKKEYKEGRDWVANNLkqSKDTGLGVSVF 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  91 EVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWAsGGSSILAEFGTLHLEFMH 170
Cdd:PTZ00470 155 ETTIRVLGGLLSAYDLTGDEMYLEKAREIADRLLPAFNEDTGFPASEINLATGRKSYPGWA-GGCSILSEVGTLQLEFNY 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864 171 LSHLSGNPIFAEKVMNIRTVLNKLEKP-QGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMYF 249
Cdd:PTZ00470 234 LSEITGDPKYAEYVDKVMDALFSMKPAiNGLYPIFLNPDAGRFCGNHISLGALGDSYYEYLLKQWLYTNGREERYRRLFV 313
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864 250 DAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADAAPEG---MAQHYLELGAEIARTCHESYNRT 326
Cdd:PTZ00470 314 ESAKGIIEHLYKRSPKGLTYIAEMDGGSLTNKMEHLACFAGGMFALGAAINITPddeKSARYMEVGEEVTKTCYETYATS 393
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864 327 FMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLH 406
Cdd:PTZ00470 394 PTGLGPEIFHFDPNSGDISPNVHDSHYILRPETVESIFILYRLTGDPKYREWAWKIFQAIEKHCKTENGYSGLKNVLTVH 473
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 767942864 407 ESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKD 455
Cdd:PTZ00470 474 PQQDDFQESFFLAETLKYLYLLFQPDHVIPLDKYVFNTEAHPIPIQKTN 522
 
Name Accession Description Interval E-value
Glyco_hydro_47 pfam01532
Glycosyl hydrolase family 47; Members of this family are alpha-mannosidases that catalyze the ...
13-451 0e+00

Glycosyl hydrolase family 47; Members of this family are alpha-mannosidases that catalyze the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).


Pssm-ID: 460241  Cd Length: 453  Bit Score: 601.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864   13 MMKHAWNNYKGYAWGLNELKPISKGGHSSslFGNIkGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNA-EISVFE 91
Cdd:pfam01532   1 AFLHAWDGYKKYAWGHDELRPISGGGNDT--FGGW-GATIVDSLDTLIIMGLTDEFEEAVDWVEKTLDFDKDStEVSVFE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864   92 VNIRFVGGLLSAYYLS--GEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWAsGGSSILAEFGTLHLEFM 169
Cdd:pfam01532  78 TTIRYLGGLLSAYDLSgdGDDVLLEKAVDLADRLLPAFDTPTGIPYPRVNLKTGKGGNGHVA-GGASSLAEAGTLQLEFT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  170 HLSHLSGNPIFAEKVMNIRTVLNKLE---KPQGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKK 246
Cdd:pfam01532 157 RLSQLTGDPKYEDLAQKIMDVLWKNQsrtPLPGLVPIYIDPDTGKFVGSNIGLGARGDSYYEYLLKQYLLTGGTDPEYRD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  247 MYFDAVQAIETHLIRKSS--SGLTYIAEWK---GGLLEHKMGHLTCFAGGMFALGADAAPEgmAQHYLELGAEIARTCHE 321
Cdd:pfam01532 237 MYEEAMDAIKKHLLFRPStpSDLLFIGELDsggGGKLSPKMDHLSCFAGGMLALGATLGLP--REGDLELAEKLTEGCYK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  322 SYNRTFMKLGPEAFRFDGGVE---------AIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRV 392
Cdd:pfam01532 315 TYDSTPTGLGPEIFYFDPCDEdcpwdedkwDFYVKIEDPHYLLRPETIESLFYLYRATGDPKYREWGWEIFQAIEKYTRT 394
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767942864  393 NGGYSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPI 451
Cdd:pfam01532 395 ECGYSGLQDVTSPPGEKEDNMESFWLAETLKYLYLLFSDDDLLSLDEWVFNTEAHPLPV 453
PTZ00470 PTZ00470
glycoside hydrolase family 47 protein; Provisional
13-455 0e+00

glycoside hydrolase family 47 protein; Provisional


Pssm-ID: 240427  Cd Length: 522  Bit Score: 575.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  13 MMKHAWNNYKGYAWGLNELKPISKGGHSSslFGniKGATIVDALDTLFIMEMKHEFEEAKSWVEENL--DFNVNAEISVF 90
Cdd:PTZ00470  79 AMKHAWEGYKEYAWGHDELRPLTKRHHEW--FG--LGLTIIDSLDTLKIMGLKKEYKEGRDWVANNLkqSKDTGLGVSVF 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864  91 EVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWAsGGSSILAEFGTLHLEFMH 170
Cdd:PTZ00470 155 ETTIRVLGGLLSAYDLTGDEMYLEKAREIADRLLPAFNEDTGFPASEINLATGRKSYPGWA-GGCSILSEVGTLQLEFNY 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864 171 LSHLSGNPIFAEKVMNIRTVLNKLEKP-QGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMYF 249
Cdd:PTZ00470 234 LSEITGDPKYAEYVDKVMDALFSMKPAiNGLYPIFLNPDAGRFCGNHISLGALGDSYYEYLLKQWLYTNGREERYRRLFV 313
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864 250 DAVQAIETHLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADAAPEG---MAQHYLELGAEIARTCHESYNRT 326
Cdd:PTZ00470 314 ESAKGIIEHLYKRSPKGLTYIAEMDGGSLTNKMEHLACFAGGMFALGAAINITPddeKSARYMEVGEEVTKTCYETYATS 393
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767942864 327 FMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGGYSGLRDVYLLH 406
Cdd:PTZ00470 394 PTGLGPEIFHFDPNSGDISPNVHDSHYILRPETVESIFILYRLTGDPKYREWAWKIFQAIEKHCKTENGYSGLKNVLTVH 473
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 767942864 407 ESYDDVQQSFFLAETLKYLYLIFSDDDLLPLEHWIFNSEAHLLPILPKD 455
Cdd:PTZ00470 474 PQQDDFQESFFLAETLKYLYLLFQPDHVIPLDKYVFNTEAHPIPIQKTN 522
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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