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Conserved domains on  [gi|767943133|ref|XP_011534245|]
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ethylmalonyl-CoA decarboxylase isoform X4 [Homo sapiens]

Protein Classification

enoyl-CoA hydratase/isomerase family protein( domain architecture ID 10158671)

enoyl-CoA hydratase/isomerase family protein similar to enoyl-CoA hydratase, which catalyzes the second step in the beta-oxidation pathway of fatty acid metabolism, the syn-addition of a water molecule across the double bond of a trans-2-enoyl-CoA thioester, resulting in the formation of a beta-hydroxyacyl-CoA thioester

CATH:  1.10.12.10
Gene Ontology:  GO:0003824
PubMed:  18470480|11263873
SCOP:  4000036

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 60-145 7.86e-17

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


:

Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 72.98  E-value: 7.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  60 EDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMF-MQN 138
Cdd:cd06558    5 RDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFIReLQE 84


                 ....*..
gi 767943133 139 TLTRFMR 145
Cdd:cd06558   85 LLRALLR 91
 
Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 60-145 7.86e-17

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 72.98  E-value: 7.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  60 EDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMF-MQN 138
Cdd:cd06558    5 RDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFIReLQE 84


                 ....*..
gi 767943133 139 TLTRFMR 145
Cdd:cd06558   85 LLRALLR 91
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 55-145 5.71e-15

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 69.04  E-value: 5.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  55 IDLQKEDnGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCM 134
Cdd:COG1024    1 VLVEREG-GVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKELAAAADPEEARAFAR 79

                         90
                 ....*....|.
gi 767943133 135 FMQNTLTRFMR 145
Cdd:COG1024   80 GLQRLFRALRR 90
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 57-131 5.92e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 49.87  E-value: 5.92e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943133  57 LQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAV-KSLGTPEDGMA 131
Cdd:PRK06688   8 LVELEDGVLTITINRPDKKNALTAAMYQALADALEAAATDPAVRVVVLTGAGRAFSAGGDIKDFpKAPPKPPDELA 83
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 62-117 5.81e-05

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 41.19  E-value: 5.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767943133   62 NGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDL 117
Cdd:pfam00378   4 AGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTGGDKAFCAGADL 59
 
Name Accession Description Interval E-value
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 60-145 7.86e-17

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 72.98  E-value: 7.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  60 EDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCMF-MQN 138
Cdd:cd06558    5 RDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKELAALSDAGEEARAFIReLQE 84


                 ....*..
gi 767943133 139 TLTRFMR 145
Cdd:cd06558   85 LLRALLR 91
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 55-145 5.71e-15

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 69.04  E-value: 5.71e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  55 IDLQKEDnGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCM 134
Cdd:COG1024    1 VLVEREG-GVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGAGKAFCAGADLKELAAAADPEEARAFAR 79

                         90
                 ....*....|.
gi 767943133 135 FMQNTLTRFMR 145
Cdd:COG1024   80 GLQRLFRALRR 90
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 57-131 5.92e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 49.87  E-value: 5.92e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943133  57 LQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAV-KSLGTPEDGMA 131
Cdd:PRK06688   8 LVELEDGVLTITINRPDKKNALTAAMYQALADALEAAATDPAVRVVVLTGAGRAFSAGGDIKDFpKAPPKPPDELA 83
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 55-119 7.64e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 49.62  E-value: 7.64e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767943133  55 IDLQKEDnGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNA 119
Cdd:PRK08260   6 IRYDVAD-GIATITLNRPDKLNAFTVTMARELIEAFDAADADDAVRAVIVTGAGRAFCAGADLSA 69
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 61-130 2.05e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 48.18  E-value: 2.05e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAV--KSLGTPEDGM 130
Cdd:PRK05870  10 DDGVALITVNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVVTGAGKAFCAGADLTALgaAPGRPAEDGL 81
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 49-131 5.40e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 47.29  E-value: 5.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  49 QFPGGSIDLQKE-DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGA-KNTFSSGSDLNAVKSLGTP 126
Cdd:PRK06144   2 AMTTSTDELLLEvRGGIARITFNRPAARNAMTWAMYEGLAEICEAIAADPSIRAVVLRGAgDKAFVAGTDIAQFRAFSTA 81


                 ....*
gi 767943133 127 EDGMA 131
Cdd:PRK06144  82 EDAVA 86
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 54-128 1.30e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 46.18  E-value: 1.30e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767943133  54 SIDLQKEDNgIGILTLNNPSRMNAFSGVMMLQLLEKVIELENwTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPED 128
Cdd:PRK07659   7 SVVVKYEGR-VATIMLNRPEALNALDEPMLKELLQALKEVAE-SSAHIVVLRGNGRGFSAGGDIKMMLSSNDESK 79
PLN02888 PLN02888
enoyl-CoA hydratase
 55-119 4.20e-06

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 44.74  E-value: 4.20e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767943133  55 IDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNA 119
Cdd:PLN02888  11 ILVPKSRNGIATITINRPKALNALTRPMMVELAAAFKRLDEDDSVKVIILTGSGRAFCSGVDLTA 75
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 61-117 1.56e-05

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 43.09  E-value: 1.56e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENwTEGKGLIVRGAKNT--FSSGSDL 117
Cdd:PRK11423  11 INKIATITFNNPAKRNALSKVLIDDLMQALSDLNR-PEIRVVILRAPSGSkvWSAGHDI 68
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 63-116 2.15e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 42.51  E-value: 2.15e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767943133  63 GIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSD 116
Cdd:PRK05864  19 EIALITLNRPERMNSMAFDVMVPLKEALAEVSYDNSVRVVVLTGAGRGFSSGAD 72
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
63-119 2.27e-05

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 42.67  E-value: 2.27e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767943133  63 GIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNA 119
Cdd:PRK08252  12 RVLIITINRPEARNAVNAAVAQGLAAALDELDADPDLSVGILTGAGGTFCAGMDLKA 68
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
 57-120 2.39e-05

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 42.78  E-value: 2.39e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767943133  57 LQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAV 120
Cdd:PLN02988  12 LVEEKSSVRILTLNRPKQLNALSFHMISRLLQLFLAFEEDPSVKLVILKGHGRAFCAGGDVAAV 75
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 61-145 2.66e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 42.21  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENwTEGKGLIVRGAKNTFSSGSDLN--AVKSLGTPED-GMAVCMFMq 137
Cdd:PRK08140  11 EAGVATLTLNRPDKLNSFTREMHRELREALDQVED-DGARALLLTGAGRGFCAGQDLAdrDVTPGGAMPDlGESIETFY- 88


                 ....*...
gi 767943133 138 NTLTRFMR 145
Cdd:PRK08140  89 NPLVRRLR 96
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 61-129 4.48e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 41.61  E-value: 4.48e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGtPEDG 129
Cdd:PRK06210  13 DSGVAVITLNRPDRLNAWTPVMEAEVYAAMDRAEADPAVRVIVLTGAGRGFCAGADMGELQTID-PSDG 80
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 62-117 5.81e-05

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 41.19  E-value: 5.81e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767943133   62 NGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDL 117
Cdd:pfam00378   4 AGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTGGDKAFCAGADL 59
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 61-117 6.41e-05

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 41.15  E-value: 6.41e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVM---MLQLLEkviELENWTEGKGLIVRGAKNTFSSGSDL 117
Cdd:PRK09120  15 EDGIAWVTLNRPEKRNAMSPTLnreMIDVLD---ALEFDDDAGVLVLTGAGDAWSAGMDL 71
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
61-145 8.10e-05

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 40.87  E-value: 8.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLE--KVIElENWTEGKGLIVRGAKNTFSSGSDL----NAVKSLGTPEDGMAVCM 134
Cdd:PRK05981  11 DGGVAILTLDHPEVMNAVSIDMLGGLAEalDAIE-DGKAEVRCLVLTGAGRGFCTGANLqgrgSGGRESDSGGDAGAALE 89

                         90
                 ....*....|.
gi 767943133 135 FMQNTLTRFMR 145
Cdd:PRK05981  90 TAYHPFLRRLR 100
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 54-118 1.16e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 40.29  E-value: 1.16e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943133  54 SIDLQKEDNG-IGILTLNNPSrMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNT-FSSGSDLN 118
Cdd:PRK09076   2 MIELDLEIDGhVAILTLNNPP-ANTWTADSLQALKQLVLELNADKDVYALVITGDGEKfFSAGADLN 67
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
61-121 1.24e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 40.34  E-value: 1.24e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEG-KGLIVRGAKNTFSSGSDLNAVK 121
Cdd:PRK09245  10 DGHIVTLTMNRPETRNALSDNDAVDALVAACAAINADRSvRAVILTGAGTAFSSGGNVKDMR 71
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
66-119 1.97e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 39.70  E-value: 1.97e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767943133  66 ILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNA 119
Cdd:PRK07799  17 IVTMNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCILTGAGGAFCAGMDLKA 70
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 54-114 2.04e-04

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 39.57  E-value: 2.04e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943133  54 SIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSG 114
Cdd:PRK07110   5 VVELREVEEGIAQVTMQDRVNKNAFSDELCDQLHEAFDTIAQDPRYKVVILTGYPNYFATG 65
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 51-132 2.30e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 39.57  E-value: 2.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  51 PGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLnavKSLGTPEDGM 130
Cdd:PRK06190   1 MTEPILLVETHDRVRTLTLNRPEARNALSAALRRALFAALAEADADDDVDVVVLTGADPAFCAGLDL---KELGGDGSAY 77


                 ..
gi 767943133 131 AV 132
Cdd:PRK06190  78 GA 79
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 54-117 3.02e-04

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 39.41  E-value: 3.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767943133  54 SIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDL 117
Cdd:PRK05674   6 TIELIRDPRGFATLWLSRADKNNAFNAQMIRELILALDQVQSDASLRFLLLRGRGRHFSAGADL 69
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 61-117 3.71e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 38.95  E-value: 3.71e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKN-TFSSGSDL 117
Cdd:PRK07657  11 TPHVVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEkAFCAGADL 68
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 57-142 4.75e-04

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 38.77  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  57 LQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDL---NAVKSLGTPEDGMAVC 133
Cdd:PRK08139  14 LREDRDGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGKAFCAGHDLkemRAARGLAYFRALFARC 93


                 ....*....
gi 767943133 134 MFMQNTLTR 142
Cdd:PRK08139  94 SRVMQAIVA 102
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 63-122 5.50e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 38.61  E-value: 5.50e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  63 GIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKS 122
Cdd:PRK06072   9 GYAIVTMSRPDKLNALNLEMRNEFISKLKQINADPKIRVVIVTGEGRAFCVGADLSEFAP 68
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 47-117 6.43e-04

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 38.53  E-value: 6.43e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767943133  47 LQQFPGGSIDLQKEDnGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGA-KNTFSSGSDL 117
Cdd:PRK06127   5 SISSPTGKLLAEKTG-GLGRITFNNPARHNAMSLDMWEALPQALAAAEDDDAIRVVVLTGAgEKAFVSGADI 75
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
51-129 8.46e-04

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 38.14  E-value: 8.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767943133  51 PGGSIDLQKEDNgIGILTLNNPSrMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLnavKSLGTPEDG 129
Cdd:PRK06495   2 MMSQLKLEVSDH-VAVVTLDNPP-VNALSRELRDELIAVFDEISERPDVRVVVLTGAGKVFCAGADL---KGRPDVIKG 75
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 54-118 1.13e-03

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 37.44  E-value: 1.13e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943133  54 SIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEkVIELENWTEGKGLIV-RGAKNTFSSGSDLN 118
Cdd:PRK09674   2 SELLVSRQQRVLLLTLNRPEARNALNNALLTQLVN-ELEAAATDTSIGVCViTGNARFFAAGADLN 66
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 64-135 1.20e-03

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 37.45  E-value: 1.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767943133   64 IGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGA-KNTFSSGSDLNAVKSLGTPEDGMAVCMF 135
Cdd:pfam16113   1 VGVITLNRPKALNALNLEMVRALLAALKAWEDDPAVKLVVLKGAgERAFCAGGDVRALYEAAKAGGGEAGRDF 73
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 64-123 1.26e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 37.33  E-value: 1.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943133  64 IGILTLNNPSRMNAFSGVMMLQLLEKVIELENwTEGKGLIV-RGAKNTFSSGSDLNAVKSL 123
Cdd:PRK05862  14 VGLITLNRPKALNALNDALMDELGAALAAFDA-DEGIGAIViTGSEKAFAAGADIKEMADL 73
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
54-120 2.08e-03

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 36.92  E-value: 2.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943133  54 SIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAV 120
Cdd:PRK07327  12 ALRFDRPPPGVLEIVLNGPGALNAADARMHRELADIWRDVDRDPDVRVVLIRGEGKAFSAGGDLALV 78
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
55-120 2.36e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 36.78  E-value: 2.36e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767943133  55 IDLQKEDnGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAV 120
Cdd:PRK07509   5 VSVTIED-GIADVRLNRPDKMNALDFAMFEELIATIKRLKKDRGIRAVILSGEGGAFCAGLDVKSV 69
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
50-128 4.12e-03

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 36.38  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  50 FPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSL-GTPED 128
Cdd:PRK11730   3 YQGKTLQVDWLEDGIAELVFDAPGSVNKLDRATLASLGEALDALEAQSDLKGLLLTSAKDAFIVGADITEFLSLfAAPEE 82
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
55-129 4.60e-03

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 35.88  E-value: 4.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767943133  55 IDLQKEDNgIGILTLNNPSRMNAFSGvMMLQLLEKVIE-LENWTEGKGLIVRGA-KNTFSSGSDLNAVKSLgTPEDG 129
Cdd:PRK05809   6 VILEKEGH-IAVVTINRPKALNALNS-ETLKELDTVLDdIENDDNVYAVILTGAgEKAFVAGADISEMKDL-NEEEG 79
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
61-129 5.00e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 35.71  E-value: 5.00e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAV------KSLGTPEDG 129
Cdd:PRK06563   6 RGHVLLIGLDRPAKRNAFDSAMLDDLALALGEYEADDELRVAVLFAHGEHFTAGLDLADVapklaaGGFPFPEGG 80
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
 46-128 5.43e-03

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 35.93  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  46 TLQQFPGGSIDLQKEDNGIGILTLNNPSRMNAFSGVMMLQLLEKvieLENWTE---GKGLIVRGAKNTFSSGSDLNAVKS 122
Cdd:PLN02874   3 QQVQNPAEEVVLGEEKGRVRVITLNRPRQLNVISLSVVSLLAEF---LEQWEKddsVELIIIKGAGRAFSAGGDLKMFYD 79


                 ....*.
gi 767943133 123 LGTPED 128
Cdd:PLN02874  80 GRESDD 85
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 66-118 5.83e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 35.36  E-value: 5.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767943133  66 ILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLN 118
Cdd:PRK07511  15 VLTLSNPGARNALHPDMYAAGIEALNTAERDPSIRAVVLTGAGGFFCAGGNLN 67
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
60-117 6.63e-03

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 35.38  E-value: 6.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767943133  60 EDNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENwtEGKGLIVRGAKNTFSSGSDL 117
Cdd:PRK08150   8 LDGGVATIGLNRPAKRNALNDGLIAALRAAFARLPE--GVRAVVLHGEGDHFCAGLDL 63
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 55-142 6.78e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 35.38  E-value: 6.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767943133  55 IDLQKEDnGIGILTLNNPSrMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVKSLGTPEDGMAVCM 134
Cdd:PRK07658   4 LSVRVED-HVAVITLNHPP-ANALSSQVLHELSELLDQVEKDDNVRVVVIHGEGRFFSAGADIKEFTSVTEAEQATELAQ 81


                 ....*...
gi 767943133 135 FMQNTLTR 142
Cdd:PRK07658  82 LGQVTFER 89
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 61-121 6.97e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 35.49  E-value: 6.97e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767943133  61 DNGIGILTLNNPSRMNAFSGVMMLQLLEKVIELENWTEGKGLIVRGAKNTFSSGSDLNAVK 121
Cdd:PRK07260   9 EDDLATLTLNRPEVSNGFNIPMCQEILEALRLAEEDPSVRFLLINANGKVFSVGGDLVEMK 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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