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Conserved domains on  [gi|767979537|ref|XP_011534657|]
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protein transport protein Sec23A isoform X2 [Homo sapiens]

Protein Classification

protein transport protein sec23( domain architecture ID 1004043)

protein transport protein sec23 is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

CATH:  1.20.120.730
Gene Ontology:  GO:0006886|GO:0008270|GO:0005096
PubMed:  8898360|18534853

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN00162 super family cl33419
transport protein sec23; Provisional
12-762 0e+00

transport protein sec23; Provisional


The actual alignment was detected with superfamily member PLN00162:

Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 1127.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  12 EERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCsrTTCRAVLNPLCQVDYRAKLWACNFCYQR 91
Cdd:PLN00162   7 EAIDGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPLRC--RTCRAVLNPYCRVDFQAKIWICPFCFQR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  92 NQFPPSYAGISELNQPAELLPQFSSIEYVVLR---GPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLIT 168
Cdd:PLN00162  85 NHFPPHYSSISETNLPAELFPQYTTVEYTLPPgsgGAPSPPVFVFVVDTCMIEEELGALKSALLQAIALLPENALVGLIT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 169 FGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPLTQATRGPQVQQPPPS----NRFLQPVQKIDMNLTDLL 244
Cdd:PLN00162 165 FGTHVHVHELGFSECSKSYVFRGNKEVSKDQILEQLGLGGKKRRPAGGGIAGARDGLSssgvNRFLLPASECEFTLNSAL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 245 GELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYV 324
Cdd:PLN00162 245 EELQKDPWPVPPGHRPARCTGAALSVAAGLLGACVPGTGARIMAFVGGPCTEGPGAIVSKDLSEPIRSHKDLDKDAAPYY 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 325 KKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGG 404
Cdd:PLN00162 325 KKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGHSVFKDSLRRVFERDGEGSLGLSFNG 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 405 TLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNA-PIPQGGRGAIQFVT 483
Cdd:PLN00162 405 TFEVNCSKDVKVQGAIGPCASLEKKGPSVSDTEIGEGGTTAWKLCGLDKKTSLAVFFEVANSGQSnPQPPGQQFFLQFLT 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 484 QYQHSSGQRRIRVTTIARNWADAqTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKD 563
Cdd:PLN00162 485 RYQHSNGQTRLRVTTVTRRWVEG-SSSEELVAGFDQEAAAVVMARLASHKMETEEEFDATRWLDRALIRLCSKFGDYRKD 563
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 564 DPSSFRFSETFSLYPQrrdfpktsgeilenqekarsaclkFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMI 643
Cdd:PLN00162 564 DPSSFRLSPNFSLYPQ------------------------FMFNLRRSQFVQVFNNSPDETAYFRMMLNRENVTNSLVMI 619
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 644 QPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSR 723
Cdd:PLN00162 620 QPTLISYSFNGPPEPVLLDVASIAADRILLLDSYFSVVIFHGSTIAQWRKAGYHNQPEHEAFAQLLEAPQADAQAIIKER 699
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|
gi 767979537 724 FPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAW-GQEI 762
Cdd:PLN00162 700 FPVPRLVVCDQHGSQARFLLAKLNPSATYNSANAMgGSDI 739
 
Name Accession Description Interval E-value
PLN00162 PLN00162
transport protein sec23; Provisional
12-762 0e+00

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 1127.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  12 EERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCsrTTCRAVLNPLCQVDYRAKLWACNFCYQR 91
Cdd:PLN00162   7 EAIDGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPLRC--RTCRAVLNPYCRVDFQAKIWICPFCFQR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  92 NQFPPSYAGISELNQPAELLPQFSSIEYVVLR---GPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLIT 168
Cdd:PLN00162  85 NHFPPHYSSISETNLPAELFPQYTTVEYTLPPgsgGAPSPPVFVFVVDTCMIEEELGALKSALLQAIALLPENALVGLIT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 169 FGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPLTQATRGPQVQQPPPS----NRFLQPVQKIDMNLTDLL 244
Cdd:PLN00162 165 FGTHVHVHELGFSECSKSYVFRGNKEVSKDQILEQLGLGGKKRRPAGGGIAGARDGLSssgvNRFLLPASECEFTLNSAL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 245 GELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYV 324
Cdd:PLN00162 245 EELQKDPWPVPPGHRPARCTGAALSVAAGLLGACVPGTGARIMAFVGGPCTEGPGAIVSKDLSEPIRSHKDLDKDAAPYY 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 325 KKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGG 404
Cdd:PLN00162 325 KKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGHSVFKDSLRRVFERDGEGSLGLSFNG 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 405 TLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNA-PIPQGGRGAIQFVT 483
Cdd:PLN00162 405 TFEVNCSKDVKVQGAIGPCASLEKKGPSVSDTEIGEGGTTAWKLCGLDKKTSLAVFFEVANSGQSnPQPPGQQFFLQFLT 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 484 QYQHSSGQRRIRVTTIARNWADAqTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKD 563
Cdd:PLN00162 485 RYQHSNGQTRLRVTTVTRRWVEG-SSSEELVAGFDQEAAAVVMARLASHKMETEEEFDATRWLDRALIRLCSKFGDYRKD 563
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 564 DPSSFRFSETFSLYPQrrdfpktsgeilenqekarsaclkFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMI 643
Cdd:PLN00162 564 DPSSFRLSPNFSLYPQ------------------------FMFNLRRSQFVQVFNNSPDETAYFRMMLNRENVTNSLVMI 619
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 644 QPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSR 723
Cdd:PLN00162 620 QPTLISYSFNGPPEPVLLDVASIAADRILLLDSYFSVVIFHGSTIAQWRKAGYHNQPEHEAFAQLLEAPQADAQAIIKER 699
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|
gi 767979537 724 FPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAW-GQEI 762
Cdd:PLN00162 700 FPVPRLVVCDQHGSQARFLLAKLNPSATYNSANAMgGSDI 739
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
9-762 0e+00

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 904.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537   9 QQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCsRTTCRAVLNPLCQVDYRAKLWACNFC 88
Cdd:COG5047    4 EIIEENDGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKC-TAPCKAVLNPYCHIDERNQSWICPFC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  89 YQRNQFPPSYAGISELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLIT 168
Cdd:COG5047   83 NQRNTLPPQYRDISNANLPLELLPQSSTIEYTLSKPVILPPVFFFVVDACCDEEELTALKDSLIVSLSLLPPEALVGLIT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 169 FGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKV--PLTQATRGPQVQQPPPSnRFLQPVQKIDMNLTDLLGE 246
Cdd:COG5047  163 YGTSIQVHELNAENHRRSYVFSGNKEYTKENLQELLALSKPtkSGGFESKISGIGQFASS-RFLLPTQQCEFKLLNILEQ 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 247 LQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYVKK 326
Cdd:COG5047  242 LQPDPWPVPAGKRPLRCTGSALNIASSLLEQCFPNAGCHIVLFAGGPCTVGPGTVVSTELKEPMRSHHDIESDSAQHSKK 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 327 GTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTL 406
Cdd:COG5047  322 ATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRIFNRDSEGYLKMGFNANM 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 407 EIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGG-RGAIQFVTQY 485
Cdd:COG5047  402 EVKTSKNLKIKGLIGHAVSVKKKANNISDSEIGIGATNSWKMASLSPKSNYALYFEIALGAASGSAQRPaEAYIQFITTY 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 486 QHSSGQRRIRVTTIARNWADAQTQIqnIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDP 565
Cdd:COG5047  482 QHSSGTYRIRVTTVARMFTDGGLPK--INRSFDQEAAAVFMARIAAFKAETEDIIDVFRWIDRNLIRLCQKFADYRKDDP 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 566 SSFRFSETFSLYPQrrdfpktsgeilenqekarsaclkFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQP 645
Cdd:COG5047  560 SSFRLDPNFTLYPQ------------------------FMYHLRRSPFLSVFNNSPDETAFYRHMLNNADVNDSLIMIQP 615
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 646 ILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFP 725
Cdd:COG5047  616 TLQSYSFEKGGVPVLLDSVSVKPDVILLLDTFFHILIFHGSYIAQWRNAGYQEQPEYLNLKELLEAPRLEAAELLQDRFP 695
                        730       740       750
                 ....*....|....*....|....*....|....*..
gi 767979537 726 MPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQEI 762
Cdd:COG5047  696 IPRFIVTEQGGSQARFLLSKINPSDITNKMSGGGSET 732
Sec23-like cd01478
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
126-388 9.15e-165

Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 23 is very similar to Sec24. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup lack the consensus MIDAS motif but have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238755 [Multi-domain]  Cd Length: 267  Bit Score: 476.48  E-value: 9.15e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 126 QMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLG 205
Cdd:cd01478    1 TSPPVFLFVVDTCMDEEELDALKESLIMSLSLLPPNALVGLITFGTMVQVHELGFEECSKSYVFRGNKDYTAKQIQDMLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 206 LSKV---PLTQATRGPQVQQPP-PSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPN 281
Cdd:cd01478   81 LGGPamrPSASQHPGAGNPLPSaAASRFLLPVSQCEFTLTDLLEQLQPDPWPVPAGHRPLRCTGVALSIAVGLLEACFPN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 282 TGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMK 361
Cdd:cd01478  161 TGARIMLFAGGPCTVGPGAVVSTELKDPIRSHHDIDKDNAKYYKKAVKFYDSLAKRLAANGHAVDIFAGCLDQVGLLEMK 240
                        250       260
                 ....*....|....*....|....*..
gi 767979537 362 CCPNLTGGYMVMGDSFNTSLFKQTFQR 388
Cdd:cd01478  241 VLVNSTGGHVVLSDSFTTSIFKQSFQR 267
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
126-390 1.09e-93

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 292.23  E-value: 1.09e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  126 QMPLIFLYVVDTCME---DEDLQALKESMQMSLSLLP--PTALVGLITFGRMVQVHELGCEGisksyvfRGTKDLSAKQL 200
Cdd:pfam04811   1 PQPPVFLFVIDVSYNaikSGLLAALKESLLQSLDLLPgdPRARVGFITFDSTVHFFNLGSSL-------RQPQMLVVSDL 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  201 QEMLglskvpltqatrgpqvqqPPPSNRFLQPVQKIDMNLTDLLGELQRdPWPVPqgKRPLRSSGVALSIAVGLLECTFp 280
Cdd:pfam04811  74 QDMF------------------LPLPDRFLVPLSECRFVLEDLLEQLPP-MFPVT--KRPERCLGPALQAAFLLLKAAF- 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  281 nTGARIMMFIGGPATQGPGMVVGDELKtpiRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEM 360
Cdd:pfam04811 132 -TGGKIMVFQGGLPTVGPGGKLKSRLD---ESHHGTDKEKAKLVKKADKFYKSLAKECVKQGHSVDLFAFSLDYVDVATL 207
                         250       260       270
                  ....*....|....*....|....*....|....
gi 767979537  361 KCCPNLTGGYMVMGDSFN----TSLFKQTFQRVF 390
Cdd:pfam04811 208 GQLSRLTGGQVYLYPSFQadvdGSKFKQDLQRYF 241
 
Name Accession Description Interval E-value
PLN00162 PLN00162
transport protein sec23; Provisional
12-762 0e+00

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 1127.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  12 EERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCsrTTCRAVLNPLCQVDYRAKLWACNFCYQR 91
Cdd:PLN00162   7 EAIDGVRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPELPVLPYDPLRC--RTCRAVLNPYCRVDFQAKIWICPFCFQR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  92 NQFPPSYAGISELNQPAELLPQFSSIEYVVLR---GPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLIT 168
Cdd:PLN00162  85 NHFPPHYSSISETNLPAELFPQYTTVEYTLPPgsgGAPSPPVFVFVVDTCMIEEELGALKSALLQAIALLPENALVGLIT 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 169 FGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKVPLTQATRGPQVQQPPPS----NRFLQPVQKIDMNLTDLL 244
Cdd:PLN00162 165 FGTHVHVHELGFSECSKSYVFRGNKEVSKDQILEQLGLGGKKRRPAGGGIAGARDGLSssgvNRFLLPASECEFTLNSAL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 245 GELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYV 324
Cdd:PLN00162 245 EELQKDPWPVPPGHRPARCTGAALSVAAGLLGACVPGTGARIMAFVGGPCTEGPGAIVSKDLSEPIRSHKDLDKDAAPYY 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 325 KKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGG 404
Cdd:PLN00162 325 KKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLVVLAESFGHSVFKDSLRRVFERDGEGSLGLSFNG 404
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 405 TLEIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNA-PIPQGGRGAIQFVT 483
Cdd:PLN00162 405 TFEVNCSKDVKVQGAIGPCASLEKKGPSVSDTEIGEGGTTAWKLCGLDKKTSLAVFFEVANSGQSnPQPPGQQFFLQFLT 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 484 QYQHSSGQRRIRVTTIARNWADAqTQIQNIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKD 563
Cdd:PLN00162 485 RYQHSNGQTRLRVTTVTRRWVEG-SSSEELVAGFDQEAAAVVMARLASHKMETEEEFDATRWLDRALIRLCSKFGDYRKD 563
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 564 DPSSFRFSETFSLYPQrrdfpktsgeilenqekarsaclkFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMI 643
Cdd:PLN00162 564 DPSSFRLSPNFSLYPQ------------------------FMFNLRRSQFVQVFNNSPDETAYFRMMLNRENVTNSLVMI 619
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 644 QPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSR 723
Cdd:PLN00162 620 QPTLISYSFNGPPEPVLLDVASIAADRILLLDSYFSVVIFHGSTIAQWRKAGYHNQPEHEAFAQLLEAPQADAQAIIKER 699
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|
gi 767979537 724 FPMPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAW-GQEI 762
Cdd:PLN00162 700 FPVPRLVVCDQHGSQARFLLAKLNPSATYNSANAMgGSDI 739
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
9-762 0e+00

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 904.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537   9 QQNEERDGVRFSWNVWPSSRLEATRMVVPVAALFTPLKERPDLPPIQYEPVLCsRTTCRAVLNPLCQVDYRAKLWACNFC 88
Cdd:COG5047    4 EIIEENDGIRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEPVKC-TAPCKAVLNPYCHIDERNQSWICPFC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  89 YQRNQFPPSYAGISELNQPAELLPQFSSIEYVVLRGPQMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLIT 168
Cdd:COG5047   83 NQRNTLPPQYRDISNANLPLELLPQSSTIEYTLSKPVILPPVFFFVVDACCDEEELTALKDSLIVSLSLLPPEALVGLIT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 169 FGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLGLSKV--PLTQATRGPQVQQPPPSnRFLQPVQKIDMNLTDLLGE 246
Cdd:COG5047  163 YGTSIQVHELNAENHRRSYVFSGNKEYTKENLQELLALSKPtkSGGFESKISGIGQFASS-RFLLPTQQCEFKLLNILEQ 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 247 LQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPNTGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYVKK 326
Cdd:COG5047  242 LQPDPWPVPAGKRPLRCTGSALNIASSLLEQCFPNAGCHIVLFAGGPCTVGPGTVVSTELKEPMRSHHDIESDSAQHSKK 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 327 GTKHFEALANRAATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLFKQTFQRVFTKDMHGQFKMGFGGTL 406
Cdd:COG5047  322 ATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQSFQRIFNRDSEGYLKMGFNANM 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 407 EIKTSREIKISGAIGPCVSLNSKGPCVSENEIGTGGTCQWKICGLSPTTTLAIYFEVVNQHNAPIPQGG-RGAIQFVTQY 485
Cdd:COG5047  402 EVKTSKNLKIKGLIGHAVSVKKKANNISDSEIGIGATNSWKMASLSPKSNYALYFEIALGAASGSAQRPaEAYIQFITTY 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 486 QHSSGQRRIRVTTIARNWADAQTQIqnIAASFDQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKDDP 565
Cdd:COG5047  482 QHSSGTYRIRVTTVARMFTDGGLPK--INRSFDQEAAAVFMARIAAFKAETEDIIDVFRWIDRNLIRLCQKFADYRKDDP 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 566 SSFRFSETFSLYPQrrdfpktsgeilenqekarsaclkFMFHLRRSSFLQVFNNSPDESSYYRHHFMRQDLTQSLIMIQP 645
Cdd:COG5047  560 SSFRLDPNFTLYPQ------------------------FMYHLRRSPFLSVFNNSPDETAFYRHMLNNADVNDSLIMIQP 615
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 646 ILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPVDDAQEILHSRFP 725
Cdd:COG5047  616 TLQSYSFEKGGVPVLLDSVSVKPDVILLLDTFFHILIFHGSYIAQWRNAGYQEQPEYLNLKELLEAPRLEAAELLQDRFP 695
                        730       740       750
                 ....*....|....*....|....*....|....*..
gi 767979537 726 MPRYIDTEHGGSQARFLLSKVNPSQTHNNMYAWGQEI 762
Cdd:COG5047  696 IPRFIVTEQGGSQARFLLSKINPSDITNKMSGGGSET 732
Sec23-like cd01478
Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
126-388 9.15e-165

Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 23 is very similar to Sec24. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup lack the consensus MIDAS motif but have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238755 [Multi-domain]  Cd Length: 267  Bit Score: 476.48  E-value: 9.15e-165
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 126 QMPLIFLYVVDTCMEDEDLQALKESMQMSLSLLPPTALVGLITFGRMVQVHELGCEGISKSYVFRGTKDLSAKQLQEMLG 205
Cdd:cd01478    1 TSPPVFLFVVDTCMDEEELDALKESLIMSLSLLPPNALVGLITFGTMVQVHELGFEECSKSYVFRGNKDYTAKQIQDMLG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 206 LSKV---PLTQATRGPQVQQPP-PSNRFLQPVQKIDMNLTDLLGELQRDPWPVPQGKRPLRSSGVALSIAVGLLECTFPN 281
Cdd:cd01478   81 LGGPamrPSASQHPGAGNPLPSaAASRFLLPVSQCEFTLTDLLEQLQPDPWPVPAGHRPLRCTGVALSIAVGLLEACFPN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 282 TGARIMMFIGGPATQGPGMVVGDELKTPIRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEMK 361
Cdd:cd01478  161 TGARIMLFAGGPCTVGPGAVVSTELKDPIRSHHDIDKDNAKYYKKAVKFYDSLAKRLAANGHAVDIFAGCLDQVGLLEMK 240
                        250       260
                 ....*....|....*....|....*..
gi 767979537 362 CCPNLTGGYMVMGDSFNTSLFKQTFQR 388
Cdd:cd01478  241 VLVNSTGGHVVLSDSFTTSIFKQSFQR 267
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
126-390 1.09e-93

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 292.23  E-value: 1.09e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  126 QMPLIFLYVVDTCME---DEDLQALKESMQMSLSLLP--PTALVGLITFGRMVQVHELGCEGisksyvfRGTKDLSAKQL 200
Cdd:pfam04811   1 PQPPVFLFVIDVSYNaikSGLLAALKESLLQSLDLLPgdPRARVGFITFDSTVHFFNLGSSL-------RQPQMLVVSDL 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  201 QEMLglskvpltqatrgpqvqqPPPSNRFLQPVQKIDMNLTDLLGELQRdPWPVPqgKRPLRSSGVALSIAVGLLECTFp 280
Cdd:pfam04811  74 QDMF------------------LPLPDRFLVPLSECRFVLEDLLEQLPP-MFPVT--KRPERCLGPALQAAFLLLKAAF- 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  281 nTGARIMMFIGGPATQGPGMVVGDELKtpiRSWHDIDKDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLEM 360
Cdd:pfam04811 132 -TGGKIMVFQGGLPTVGPGGKLKSRLD---ESHHGTDKEKAKLVKKADKFYKSLAKECVKQGHSVDLFAFSLDYVDVATL 207
                         250       260       270
                  ....*....|....*....|....*....|....
gi 767979537  361 KCCPNLTGGYMVMGDSFN----TSLFKQTFQRVF 390
Cdd:pfam04811 208 GQLSRLTGGQVYLYPSFQadvdGSKFKQDLQRYF 241
Sec23_C cd11287
C-terminal Actin depolymerization factor-homology domain of Sec23; The C-terminal domain of ...
634-754 2.23e-84

C-terminal Actin depolymerization factor-homology domain of Sec23; The C-terminal domain of the Sec23 subunit of the coat protein complex II (COPII) is distantly related to gelsolin-like repeats and the actin depolymerizing domains found in cofilin and similar proteins. Sec23 forms a tight complex with Sec24. The cytoplasmic Sec23/24 complex is recruited together with Sar1-GTP and Sec13/31 to induce coat polymerization and membrane deformation in the forming of COPII-coated endoplasmic reticulum vesicles. The function of the Sec23 C-terminal domain is unclear.


Pssm-ID: 200443 [Multi-domain]  Cd Length: 121  Bit Score: 263.08  E-value: 2.23e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 634 QDLTQSLIMIQPILYAYSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQWRKSGYQDMPEYENFRHLLQAPV 713
Cdd:cd11287    1 EDVSNSLIMIQPTLYSYSFNGPPEPVLLDSSSILPDRILLLDTFFHILIYHGETIAQWRKAGYQDQPEYENFKDLLEAPV 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767979537 714 DDAQEILHSRFPMPRYIDTEHGGSQARFLLSKVNPSQTHNN 754
Cdd:cd11287   81 DDAQELLQDRFPMPRYIVTEQGGSQARFLLSKVNPSQTHNN 121
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
126-388 2.02e-82

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 262.57  E-value: 2.02e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 126 QMPLIFLYVVDTCME---DEDLQALKESMQMSLSLLP--PTALVGLITFGRMVQVHELGCEGI-SKSYVFRGTKDLsakq 199
Cdd:cd01468    1 PQPPVFVFVIDVSYEaikEGLLQALKESLLASLDLLPgdPRARVGLITYDSTVHFYNLSSDLAqPKMYVVSDLKDV---- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 200 lqemlglskvpltqatrgpqvqQPPPSNRFLQPVQKIDMNLTDLLGELQRDPWPVPqGKRPLRSSGVALSIAVGLLECTF 279
Cdd:cd01468   77 ----------------------FLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPVP-THRPERCLGPALQAAFLLLKGTF 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 280 pnTGARIMMFIGGPATQGPGMVVGDELKTPIRSWhdidkDNAKYVKKGTKHFEALANRAATTGHVIDIYACALDQTGLLE 359
Cdd:cd01468  134 --AGGRIIVFQGGLPTVGPGKLKSREDKEPIRSH-----DEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVAT 206
                        250       260       270
                 ....*....|....*....|....*....|...
gi 767979537 360 MKCCPNLTGGYMVMGDSFN----TSLFKQTFQR 388
Cdd:cd01468  207 LKQLAKSTGGQVYLYDSFQapndGSKFKQDLQR 239
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
401-504 5.22e-32

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 119.18  E-value: 5.22e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  401 GFGGTLEIKTSREIKISGAIGPCVSLNSkgpcvseneigtGGTcqWKICGLSPTTTLAIYFEvvnqHNAPIPQGGRGAIQ 480
Cdd:pfam08033   1 GFNAVLRVRTSKGLKVSGFIGNFVSRSS------------GDT--WKLPSLDPDTSYAFEFD----IDEPLPNGSNAYIQ 62
                          90       100
                  ....*....|....*....|....
gi 767979537  481 FVTQYQHSSGQRRIRVTTIARNWA 504
Cdd:pfam08033  63 FALLYTHSSGERRIRVTTVALPVT 86
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
518-641 4.38e-29

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 111.44  E-value: 4.38e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  518 DQEAAAILMARLAIYRAETEEGPDVLRWLDRQLIRLCQKFGEYHKD--DPSSFRFSETFSLYPQrrdfpktsgeilenqe 595
Cdd:pfam04815   1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASssSPGQLILPESLKLLPL---------------- 64
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767979537  596 karsaclkFMFHLRRSSFLQVFNNSP-DESSYYRHHFMRQDLTQSLI 641
Cdd:pfam04815  65 --------YMLALLKSPALRGGNSSPsDERAYARHLLLSLPVEELLL 103
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
58-97 2.57e-15

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 70.17  E-value: 2.57e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 767979537   58 PVLCSRttCRAVLNPLCQVDYRAKLWACNFCYQRNQFPPS 97
Cdd:pfam04810   1 PVRCRR--CRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
9-691 2.96e-15

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 80.22  E-value: 2.96e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537   9 QQNEERDGVRFSWNVWP--SSRLEATRmvVPVAALFTPLKE-RPDLPPIQYE----PVLCSRttCRAVLNPLCQVDYRAK 81
Cdd:COG5028  145 QSNCSPKYVRSTMYAIPetNDLLKKSK--IPFGLVIRPFLElYPEEDPVPLVedgsIVRCRR--CRSYINPFVQFIEQGR 220
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  82 LWACNFCYQRNQFP-----PSYAGI--SELNQPAELLpqFSSIEYVV-----LRGPQmPLIFLYVVDT---CMEDEDLQA 146
Cdd:COG5028  221 KWRCNICRSKNDVPegfdnPSGPNDprSDRYSRPELK--SGVVDFLApkeysLRQPP-PPVYVFLIDVsfeAIKNGLVKA 297
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 147 LKESMQMSLSLLP---PTALVGLITFGRMVqvhelgcegisksYVFRGTKDLSAKQLqemlglskvpLTQATRGPQVqqP 223
Cdd:COG5028  298 AIRAILENLDQIPnfdPRTKIAIICFDSSL-------------HFFKLSPDLDEQML----------IVSDLDEPFL--P 352
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 224 PPSNRFLQPVQKIDMNLTDLLGELQRdpwpVPQGKR-PLRSSGVALSIAVGLLEctfpNTGARIMMFIGGPATQGPGMVv 302
Cdd:COG5028  353 FPSGLFVLPLKSCKQIIETLLDRVPR----IFQDNKsPKNALGPALKAAKSLIG----GTGGKIIVFLSTLPNMGIGKL- 423
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 303 gdELKTPIRSWHDIDKDnaKYVKKGTKHFealanraATTGHVIDIYACALDQTGLLEMKCCPNLTGGYMVMGDSFNTSLF 382
Cdd:COG5028  424 --QLREDKESSLLSCKD--SFYKEFAIEC-------SKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATRP 492
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 383 KQTFQrvFTKDM--HGQFKMGFGGTLEIKTSREIKISGAIGPCVSlNSKGPCvsenEIGTggtcqwkicgLSPTTTLAIY 460
Cdd:COG5028  493 NDATK--LANDLvsHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFN-RSSDLC----AFST----------MPRDTSLLVE 555
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 461 FEVVNQHNAPipqggRGAIQFVTQYQHSSGQRRIRVTTIArnwADAQTQIQNIAASFDQEAAAILMARLAIyraeTEEGP 540
Cdd:COG5028  556 FSIDEKLMTS-----DVYFQVALLYTLNDGERRIRVVNLS---LPTSSSIREVYASADQLAIACILAKKAS----TKALN 623
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 541 DVLRWLDRQLIRLCQKFGEYHKDDPSSFRFSETFSLYPQRRDFPktsgeilenqekarsaclKFMFHLRRSSFLQVFNNS 620
Cdd:COG5028  624 SSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLP------------------LLMLALLKSSAFRSGSTP 685
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767979537 621 PDESSYYRHHFMRQDLTQSLIMIQPILYA----YSFSGPPEPVLLDSSSILADRILLMDTFFQILIYHGETIAQW 691
Cdd:COG5028  686 SDIRISALNRLTSLPLKQLMRNIYPTLYAlhdmPIEAGLPDEGLLVLPSPINATSSLLESGGLYLIDTGQKIFLW 760
Gelsolin pfam00626
Gelsolin repeat;
656-742 7.96e-14

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 66.95  E-value: 7.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537  656 PEPVLLDSSSILADRILLMDTFFqiliyhgeTIAQWRksGYQDMPEYENFRHLLQAPVDDAQeilhsRFPMPRYIDTEHG 735
Cdd:pfam00626   5 PPPVPLSQESLNSGDCYLLDNGF--------TIFLWV--GKGSSLLEKLFAALLAAQLDDDE-----RFPLPEVIRVPQG 69

                  ....*..
gi 767979537  736 GSQARFL 742
Cdd:pfam00626  70 KEPARFL 76
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
644-742 9.35e-14

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 67.39  E-value: 9.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979537 644 QPILYAYSFSG--PPEPVLLDSSSILADRILLMDTFFQILIYHGEtiaqwrksgyqdmpeyENFRHLLQAPVDDAQEILH 721
Cdd:cd11280    1 PPRLYRVRGSKaiEIEEVPLASSSLDSDDVFVLDTGSEIYIWQGR----------------ASSQAELAAAALLAKELDE 64
                         90       100
                 ....*....|....*....|.
gi 767979537 722 SRFPMPRYIDTEHGGSQARFL 742
Cdd:cd11280   65 ERKGKPEIVRIRQGQEPREFW 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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