NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767979959|ref|XP_011534835|]
View 

echinoderm microtubule-associated protein-like 5 isoform X10 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
720-1074 1.99e-38

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 1.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  720 QRFYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVV 799
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSAD--GTVR 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  800 LWDWKKGEKLSIARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRKAGDVCIWrdiflvkTVKAHDGPVFSMHALEK 876
Cdd:COG2319   146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPD 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  877 G--FVTGGKDGIVALWDDSFERCLKTYAikraalapgskglllEDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPI 951
Cdd:COG2319   216 GklLASGSADGTVRLWDLATGKLLRTLT---------------GHSGSVRSVAFSPdGRLLAsGSADGTVRLWDlATGEL 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  952 TLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLM 1028
Cdd:COG2319   281 LRTLTGH-SGGVNSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 767979959 1029 ANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNV 1074
Cdd:COG2319   357 WDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 2.58e-31

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 2.58e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959   58 RGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  218 GDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETdqgykglSVRSVCWR 292
Cdd:COG2319   184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  293 --GDHILVGTQDSEIFeIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPI 369
Cdd:COG2319   256 pdGRLLASGSADGTVR-LWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAV 333
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767979959  370 RCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1382-1769 3.29e-31

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 3.29e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1382 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1461
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1462 WQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLAGRALLSkkgllsTLEdARMQTMLAIAFGANNLTF- 1539
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLR------TLT-GHTGAVRSVAFSPDGKLLa 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1540 TGTISGDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdC 1617
Cdd:COG2319   221 SGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE---L 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1618 VRSVcrgkgkilvgtrnaeiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlG 1697
Cdd:COG2319   281 LRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-G 328
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767979959 1698 HAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 1769
Cdd:COG2319   329 HTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
2-49 7.00e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 7.00e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767979959     2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
672-715 8.99e-18

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 79.13  E-value: 8.99e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767979959   672 APGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
1317-1364 1.32e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 70.27  E-value: 1.32e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767979959  1317 KKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1364
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1651-1907 4.32e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 4.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1651 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 1728
Cdd:cd00200     5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1729 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSSYl 1799
Cdd:cd00200    75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1800 qVSSGCYKR--HVYEVPSGKHLMDHaaidritwatwtsilgdevlgiwsrHAEKADVNCACVSHSGISLVTGDDFGMVKL 1877
Cdd:cd00200   150 -VASSSQDGtiKLWDLRTGKCVATL-------------------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
                         250       260       270
                  ....*....|....*....|....*....|....
gi 767979959 1878 FDFPCPEKFVSLC----FVYYYQFTPNFDVLSSA 1907
Cdd:cd00200   204 WDLSTGKCLGTLRghenGVNSVAFSPDGYLLASG 237
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
720-1074 1.99e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 1.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  720 QRFYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVV 799
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSAD--GTVR 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  800 LWDWKKGEKLSIARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRKAGDVCIWrdiflvkTVKAHDGPVFSMHALEK 876
Cdd:COG2319   146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPD 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  877 G--FVTGGKDGIVALWDDSFERCLKTYAikraalapgskglllEDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPI 951
Cdd:COG2319   216 GklLASGSADGTVRLWDLATGKLLRTLT---------------GHSGSVRSVAFSPdGRLLAsGSADGTVRLWDlATGEL 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  952 TLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLM 1028
Cdd:COG2319   281 LRTLTGH-SGGVNSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 767979959 1029 ANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNV 1074
Cdd:COG2319   357 WDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
725-1025 2.10e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 2.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  725 GHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWDWK 804
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSD--KTIRLWDLE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  805 KGEKLSIARGSKDKIFVVKMNPYvpDKLITAGikhmkfwRKAGDVCIW--RDIFLVKTVKAHDGPVFSMHALE-KGFVTG 881
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPD--GRILSSS-------SRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPdGTFVAS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  882 GK-DGIVALWDDSFERCLKTYaikraalaPGSKGlllednpSIRAISLGH--GHILVGTKNGEILEVDKSGPITL-LVQG 957
Cdd:cd00200   153 SSqDGTIKLWDLRTGKCVATL--------TGHTG-------EVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLgTLRG 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767979959  958 HmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGS 1025
Cdd:cd00200   218 H-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 2.58e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 2.58e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959   58 RGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  218 GDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETdqgykglSVRSVCWR 292
Cdd:COG2319   184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  293 --GDHILVGTQDSEIFeIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPI 369
Cdd:COG2319   256 pdGRLLASGSADGTVR-LWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAV 333
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767979959  370 RCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1382-1769 3.29e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 3.29e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1382 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1461
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1462 WQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLAGRALLSkkgllsTLEdARMQTMLAIAFGANNLTF- 1539
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLR------TLT-GHTGAVRSVAFSPDGKLLa 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1540 TGTISGDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdC 1617
Cdd:COG2319   221 SGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE---L 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1618 VRSVcrgkgkilvgtrnaeiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlG 1697
Cdd:COG2319   281 LRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-G 328
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767979959 1698 HAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 1769
Cdd:COG2319   329 HTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
57-353 2.48e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 2.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959   57 YRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKdVHTHGIACLAFDLDGQRLVSVGLDskNAVCVWD 136
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  137 WKRGKMLSMAPGHTDRIFDISWDlyqPNK--LVSCGV-KHIKFWSLcgNALTPKRGVFGKTGDlqtILCLACARDE-LTY 212
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS---PDGriLSSSSRdKTIKVWDV--ETGKCLTTLRGHTDW---VNSVAFSPDGtFVA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  213 SGALNGDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDlretdqgYKGLSVR 287
Cdd:cd00200   152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLsTGKCLGTLR-------GHENGVN 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  288 SVCW--RGDHILVGTQDS--EIFEIVVQERNKPFlimQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:cd00200   224 SVAFspDGYLLASGSEDGtiRVWDLRTGECVQTL---SGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1430-1732 4.26e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 4.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1430 HSKGVCSVSFSATGKLLLSVGLDpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLagra 1508
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSdKTIRLWDL---- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1509 llSKKGLLSTLEDARmQTMLAIAFGANNLTFTGTIS-GDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDGLIVTGgker 1586
Cdd:cd00200    81 --ETGECVRTLTGHT-SYVSSVAFSPDGRILSSSSRdKTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVAS---- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1587 pSKEGGAVKLWD-QELRRCRAFRLETGQatdcVRSVC--RGKGKILVGTRNAEIIEVGEKNAACNILVNGHvDGPIWGLA 1663
Cdd:cd00200   153 -SSQDGTIKLWDlRTGKCVATLTGHTGE----VNSVAfsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVA 226
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767979959 1664 THPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlGHAAR--TVCYSPEGDMVAIGMKNGefiillvsSLKIW 1732
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSvtSLAWSPDGKRLASGSADG--------TIRIW 288
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
2-49 7.00e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 7.00e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767979959     2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
672-715 8.99e-18

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 79.13  E-value: 8.99e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767979959   672 APGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
1317-1364 1.32e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 70.27  E-value: 1.32e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767979959  1317 KKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1364
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1651-1907 4.32e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 4.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1651 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 1728
Cdd:cd00200     5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1729 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSSYl 1799
Cdd:cd00200    75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1800 qVSSGCYKR--HVYEVPSGKHLMDHaaidritwatwtsilgdevlgiwsrHAEKADVNCACVSHSGISLVTGDDFGMVKL 1877
Cdd:cd00200   150 -VASSSQDGtiKLWDLRTGKCVATL-------------------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
                         250       260       270
                  ....*....|....*....|....*....|....
gi 767979959 1878 FDFPCPEKFVSLC----FVYYYQFTPNFDVLSSA 1907
Cdd:cd00200   204 WDLSTGKCLGTLRghenGVNSVAFSPDGYLLASG 237
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
1703-1785 1.43e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.35  E-value: 1.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  1703 VCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRR-CAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCK 1781
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEdLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80

                   ....
gi 767979959  1782 DIPS 1785
Cdd:pfam12894   81 DLIT 84
WD40 COG2319
WD40 repeat [General function prediction only];
1663-1879 1.87e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1663 ATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC-YSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCA 1741
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1742 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIsycKDIPSFVIQMDFSADSSYLqVSSGCYKR-HVYEVPSGKH-- 1818
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTL-ASGSADGTvRLWDLATGKLlr 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767979959 1819 -LMDHA-AIDRITWA----TWTSILGDEVLGIWSRHAEK---------ADVNCACVSHSGISLVTGDDFGMVKLFD 1879
Cdd:COG2319   157 tLTGHSgAVTSVAFSpdgkLLASGSDDGTVRLWDLATGKllrtltghtGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
760-802 3.71e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767979959    760 TIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:smart00320    1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
1652-1684 4.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 4.06e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767979959   1652 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1684
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-353 1.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.24e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767979959   314 NKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:pfam00400    1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
315-353 2.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 2.12e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767979959    315 KPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:smart00320    3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
762-802 4.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 4.58e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767979959   762 KPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:pfam00400    2 KLLKTLEGHTG-SVTSLAFSPDGKLLASGSDD--GTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
720-1074 1.99e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 1.99e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  720 QRFYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVV 799
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSAD--GTVR 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  800 LWDWKKGEKLSIARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRKAGDVCIWrdiflvkTVKAHDGPVFSMHALEK 876
Cdd:COG2319   146 LWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPD 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  877 G--FVTGGKDGIVALWDDSFERCLKTYAikraalapgskglllEDNPSIRAISLGH-GHILV-GTKNGEILEVD-KSGPI 951
Cdd:COG2319   216 GklLASGSADGTVRLWDLATGKLLRTLT---------------GHSGSVRSVAFSPdGRLLAsGSADGTVRLWDlATGEL 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  952 TLLVQGHmEGEVWGLATHP---YLpicATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLM 1028
Cdd:COG2319   281 LRTLTGH-SGGVNSVAFSPdgkLL---ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 767979959 1029 ANADTLEDLVSFHHRKDMISDIRFSPgSGKYLAVASHDSFIDIYNV 1074
Cdd:COG2319   357 WDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
725-1025 2.10e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 2.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  725 GHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWDWK 804
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSD--KTIRLWDLE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  805 KGEKLSIARGSKDKIFVVKMNPYvpDKLITAGikhmkfwRKAGDVCIW--RDIFLVKTVKAHDGPVFSMHALE-KGFVTG 881
Cdd:cd00200    82 TGECVRTLTGHTSYVSSVAFSPD--GRILSSS-------SRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPdGTFVAS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  882 GK-DGIVALWDDSFERCLKTYaikraalaPGSKGlllednpSIRAISLGH--GHILVGTKNGEILEVDKSGPITL-LVQG 957
Cdd:cd00200   153 SSqDGTIKLWDLRTGKCVATL--------TGHTG-------EVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLgTLRG 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767979959  958 HmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGS 1025
Cdd:cd00200   218 H-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
719-1025 7.45e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 7.45e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  719 TQRFYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTV 798
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSPDGKTLASG--SADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDD--GTV 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  799 VLWDWKKGEKLSIARGSKDKIFVVKMNPyvpD--KLITAGI-KHMKFWRKAGDVCIwrdiflvKTVKAHDGPVFSMHALE 875
Cdd:COG2319   187 RLWDLATGKLLRTLTGHTGAVRSVAFSP---DgkLLASGSAdGTVRLWDLATGKLL-------RTLTGHSGSVRSVAFSP 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  876 KG--FVTGGKDGIVALWDDSFERCLKTY-----AIKRAALAPGSKglllednpsiraislghgHILVGTKNGEILEVD-K 947
Cdd:COG2319   257 DGrlLASGSADGTVRLWDLATGELLRTLtghsgGVNSVAFSPDGK------------------LLASGSDDGTVRLWDlA 318
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767979959  948 SGPITLLVQGHmEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGS 1025
Cdd:COG2319   319 TGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
58-438 2.58e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 2.58e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959   58 RGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNAVCVWDW 137
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWDL 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  138 KRGKMLSMAPGHTDRIFDISWDlyqPNklvscgvkhikfwslcgnaltpkrgvfGKTgdlqtilcLAcardeltySGALN 217
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAFS---PD---------------------------GKL--------LA--------SGSDD 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  218 GDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDLRETdqgykglSVRSVCWR 292
Cdd:COG2319   184 GTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLaTGKLLRTLTGHSG-------SVRSVAFS 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  293 --GDHILVGTQDSEIFeIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPI 369
Cdd:COG2319   256 pdGRLLASGSADGTVR-LWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAV 333
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767979959  370 RCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVA 438
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
1382-1769 3.29e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 3.29e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1382 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1461
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1462 WQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLAGRALLSkkgllsTLEdARMQTMLAIAFGANNLTF- 1539
Cdd:COG2319   149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLR------TLT-GHTGAVRSVAFSPDGKLLa 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1540 TGTISGDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdC 1617
Cdd:COG2319   221 SGSADGTVRLWDlATGKLLRTLTGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGE---L 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1618 VRSVcrgkgkilvgtrnaeiievgeknaacnilvnGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlG 1697
Cdd:COG2319   281 LRTL-------------------------------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-G 328
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767979959 1698 HAA--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLT 1769
Cdd:COG2319   329 HTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
52-354 1.29e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 1.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959   52 HRQKFYRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKDvHTHGIACLAFDLDGQRLVSVGLDskNA 131
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GT 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  132 VCVWDWKRGKMLSMAPGHTDRIFDISWDlyqPN--KLVSCGV-KHIKFWSLcgnaltpKRGVFGKT--GDLQTILCLACA 206
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkLLASGSAdGTVRLWDL-------ATGKLLRTltGHSGSVRSVAFS 255
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  207 RDELT-YSGALNGDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIdlretdQG 280
Cdd:COG2319   256 PDGRLlASGSADGTVRLWdlATGELLRTLTG-HSGGVNSVAFSPDGklLASGSDDGTVRLWDLaTGKLLRTL------TG 328
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767979959  281 YKGlSVRSVCWR--GDHILVGTQDSEI--FEIvvqERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSL 354
Cdd:COG2319   329 HTG-AVRSVAFSpdGKTLASGSDDGTVrlWDL---ATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
57-353 2.48e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 2.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959   57 YRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKdVHTHGIACLAFDLDGQRLVSVGLDskNAVCVWD 136
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  137 WKRGKMLSMAPGHTDRIFDISWDlyqPNK--LVSCGV-KHIKFWSLcgNALTPKRGVFGKTGDlqtILCLACARDE-LTY 212
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS---PDGriLSSSSRdKTIKVWDV--ETGKCLTTLRGHTDW---VNSVAFSPDGtFVA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  213 SGALNGDIYVW--KGINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIDlretdqgYKGLSVR 287
Cdd:cd00200   152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLsTGKCLGTLR-------GHENGVN 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  288 SVCW--RGDHILVGTQDS--EIFEIVVQERNKPFlimQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:cd00200   224 SVAFspDGYLLASGSEDGtiRVWDLRTGECVQTL---SGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
260-802 3.84e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 3.84e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  260 RLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHcEGELWALAVHPTKPL 339
Cdd:COG2319    14 ADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  340 AVTGSDDRSVRIWSLVDHALIARCNM-EEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSP 418
Cdd:COG2319    93 LASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  419 DGTYLAVGCNDSSVDIYGVAQrykkvGECLGSL----SFITHLDWSSDSRYLQTNDGNGK-RLfYRMPGGKEVTSTEEik 493
Cdd:COG2319   173 DGKLLASGSDDGTVRLWDLAT-----GKLLRTLtghtGAVRSVAFSPDGKLLASGSADGTvRL-WDLATGKLLRTLTG-- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  494 gvHWASWTCVSglevngiWpkysdindinSVDGnyigQVLVTADDYGIIKLFRypcLRKGAKFRKYIGHSAHVTNVRWSH 573
Cdd:COG2319   245 --HSGSVRSVA-------F----------SPDG----RLLASGSADGTVRLWD---LATGELLRTLTGHSGGVNSVAFSP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  574 DYQWVISiGGADHSVFQWkfiperklkdavhiapqesladshsdesdsdlsdvpeldseieqetqltyrrqvykedlpql 653
Cdd:COG2319   299 DGKLLAS-GSDDGTVRLW-------------------------------------------------------------- 315
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  654 keqckekqksatskrrERAPGNSIRLHfvhgyrgydcrsnlfytqigeivyhvaavgviynrqqntqrfyLGHDDDILCL 733
Cdd:COG2319   316 ----------------DLATGKLLRTL-------------------------------------------TGHTGAVRSV 336
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767979959  734 TIHPLKDYVATGqvGRDPSIHIWDTETIKPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:COG2319   337 AFSPDGKTLASG--SDDGTVRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSAD--GTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
251-591 7.14e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 7.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  251 ATGGRDGCIRLWDLTFKPITVIDLRETDqgykglSVRSVCWR--GDHILVGTQDSEI--FEIvvqERNKPFLIMQGHcEG 326
Cdd:COG2319    94 ASASADGTVRLWDLATGLLLRTLTGHTG------AVRSVAFSpdGKTLASGSADGTVrlWDL---ATGKLLRTLTGH-SG 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  327 ELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIK 405
Cdd:COG2319   164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  406 DRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQrykkvGECLGSL----SFITHLDWSSDSRYLQTNDGNGKrlfyrmp 481
Cdd:COG2319   244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLtghsGGVNSVAFSPDGKLLASGSDDGT------- 311
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  482 ggkevtsteeIKGVHWASWTCVSGLEVNGIWpkysdindINSVDGNYIGQVLVTADDYGIIKLFRypcLRKGAKFRKYIG 561
Cdd:COG2319   312 ----------VRLWDLATGKLLRTLTGHTGA--------VRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTG 370
                         330       340       350
                  ....*....|....*....|....*....|
gi 767979959  562 HSAHVTNVRWSHDYQWVISiGGADHSVFQW 591
Cdd:COG2319   371 HTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
148-435 2.48e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 2.48e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  148 GHTDRIFDISWDlYQPNKLVSCGV-KHIKFWSLCGNalTPKRGVFGKTGDLQTilCLACARDELTYSGALNGDIYVW--K 224
Cdd:cd00200     7 GHTGGVTCVAFS-PDGKLLATGSGdGTIKVWDLETG--ELLRTLKGHTGPVRD--VAASADGTYLASGSSDKTIRLWdlE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  225 GINLIRTIQGaHAAGIFSMNACEEG--FATGGRDGCIRLWDL-TFKPITVIdlretdQGYKGlSVRSVCWRGDHILV--G 299
Cdd:cd00200    82 TGECVRTLTG-HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVeTGKCLTTL------RGHTD-WVNSVAFSPDGTFVasS 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  300 TQDSEIFEIVVQErNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCN-MEEPIRCAAVNADG 378
Cdd:cd00200   154 SQDGTIKLWDLRT-GKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPDG 231
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767979959  379 IHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIY 435
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
1411-1687 3.47e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 3.47e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1411 SIHIWDAMNKQTLSILRCyHSKGVCSVSFSATGKLLLSVGLDpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTq 1490
Cdd:COG2319   143 TVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL- 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1491 FVSVGV-KHVKFWTLAGRALLSkkgllsTLEDARmQTMLAIAFGANNLTF-TGTISGDVCVWK-DHILCRIVARAHNGPV 1567
Cdd:COG2319   219 LASGSAdGTVRLWDLATGKLLR------TLTGHS-GSVRSVAFSPDGRLLaSGSADGTVRLWDlATGELLRTLTGHSGGV 291
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1568 FAMyTTLRDG-LIVTGGkerpskEGGAVKLWDQELRRC-RAFRLETGQatdcVRSVC-RGKGKILVGTRNAEIIEVGE-K 1643
Cdd:COG2319   292 NSV-AFSPDGkLLASGS------DDGTVRLWDLATGKLlRTLTGHTGA----VRSVAfSPDGKTLASGSDDGTVRLWDlA 360
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 767979959 1644 NAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIAD 1687
Cdd:COG2319   361 TGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
1382-1879 2.41e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 2.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1382 LTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRcYHSKGVCSVSFSATGKLLLSVGLDpeHTITIWR 1461
Cdd:COG2319    30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-GHTAAVLSVAFSPDGRLLASASAD--GTVRLWD 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1462 WQEGAKIASRAGHNQRIFVAEFRPDSDTqFVSVGV-KHVKFWTLAGRALLSkkgllstledarmqtmlaiafgannlTFT 1540
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKT-LASGSAdGTVRLWDLATGKLLR--------------------------TLT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1541 GtisgdvcvwkdhilcrivaraHNGPVFAMyTTLRDG-LIVTGGkerpskEGGAVKLWDqelrrcrafrLETGQatdCVR 1619
Cdd:COG2319   160 G---------------------HSGAVTSV-AFSPDGkLLASGS------DDGTVRLWD----------LATGK---LLR 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1620 SVcrgkgkilvgtrnaeiievgeknaacnilvNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlGHA 1699
Cdd:COG2319   199 TL------------------------------TGH-TGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHS 246
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1700 A--RTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRI 1777
Cdd:COG2319   247 GsvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL 326
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1778 sycKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKhlmdhaaidritwatwtsilgdeVLGIWSRHAekADVNCA 1857
Cdd:COG2319   327 ---TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-----------------------LLRTLTGHT--GAVTSV 378
                         490       500
                  ....*....|....*....|..
gi 767979959 1858 CVSHSGISLVTGDDFGMVKLFD 1879
Cdd:COG2319   379 AFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1430-1732 4.26e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 4.26e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1430 HSKGVCSVSFSATGKLLLSVGLDpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSdTQFVSVGV-KHVKFWTLagra 1508
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSdKTIRLWDL---- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1509 llSKKGLLSTLEDARmQTMLAIAFGANNLTFTGTIS-GDVCVWK-DHILCRIVARAHNGPVFAMyTTLRDGLIVTGgker 1586
Cdd:cd00200    81 --ETGECVRTLTGHT-SYVSSVAFSPDGRILSSSSRdKTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVAS---- 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1587 pSKEGGAVKLWD-QELRRCRAFRLETGQatdcVRSVC--RGKGKILVGTRNAEIIEVGEKNAACNILVNGHvDGPIWGLA 1663
Cdd:cd00200   153 -SSQDGTIKLWDlRTGKCVATLTGHTGE----VNSVAfsPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVA 226
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767979959 1664 THPSRDFFLSAAEDGTVRLWDIADKKMLNKVNlGHAAR--TVCYSPEGDMVAIGMKNGefiillvsSLKIW 1732
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHTNSvtSLAWSPDGKRLASGSADG--------TIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
228-592 1.82e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  228 LIRTIQGaHAAGIFSM--NACEEGFATGGRDGCIRLWDLTFKpitviDLRETDQGYKGlSVRSVCWRGDH--ILVGTQDS 303
Cdd:cd00200     1 LRRTLKG-HTGGVTCVafSPDGKLLATGSGDGTIKVWDLETG-----ELLRTLKGHTG-PVRDVAASADGtyLASGSSDK 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  304 EIFeIVVQERNKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNM-EEPIRCAAVNADGIHLA 382
Cdd:cd00200    74 TIR-LWDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVA 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  383 LGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRyKKVGECLGSLSFITHLDWSSD 462
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPD 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  463 SRYLqtndgngkrlfyrmpggkevtsteeikgvhwaswtcvsglevngiwpkysdindinsvdgnyigqvlVTADDYGII 542
Cdd:cd00200   231 GYLL-------------------------------------------------------------------ASGSEDGTI 243
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 767979959  543 KLFRypcLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISiGGADHSVFQWK 592
Cdd:cd00200   244 RVWD---LRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
2-49 7.00e-19

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 82.60  E-value: 7.00e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767979959     2 AARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSP 49
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
672-715 8.99e-18

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 79.13  E-value: 8.99e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 767979959   672 APGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNR 715
Cdd:pfam03451   29 PPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1372-1684 1.17e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 1.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1372 YQEHNDDILCLTVNQHPKFInivATGqvgdSADmsataPSIHIWDaMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGL 1451
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLL---ATG----SGD-----GTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSS 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1452 DpeHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSdtQFVSVGVKH--VKFWTLAgrallsKKGLLSTLEDARMQTMlA 1529
Cdd:cd00200    72 D--KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVE------TGKCLTTLRGHTDWVN-S 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1530 IAF-GANNLTFTGTISGDVCVWKDHIL-CRIVARAHNGPVFAMYTTLRDGLIVTGGkerpskEGGAVKLWDQELRRCRA- 1606
Cdd:cd00200   141 VAFsPDGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLGt 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767979959 1607 FRLETGQATDCVRSvcrGKGKILVGTRNAEIIEVGE-KNAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1684
Cdd:cd00200   215 LRGHENGVNSVAFS---PDGYLLASGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
444-891 4.71e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 4.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  444 VGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGGKEVTS-TEEIKGVHWASWtcvsglevngiwpkysdindin 522
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTlKGHTGPVRDVAA---------------------- 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  523 SVDGNYIgqvLVTADDyGIIKLFRypcLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISiGGADHSVFQWKFIPERKLKDa 602
Cdd:cd00200    60 SADGTYL---ASGSSD-KTIRLWD---LETGECVRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTT- 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  603 vhiapqesladshsdesdsdlsdvpeldseieqetqltyrrqvykedlpqlkeqckekqksatskrrerapgnsirlhfv 682
Cdd:cd00200       --------------------------------------------------------------------------------
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  683 hgyrgydcrsnlfytqigeivyhvaavgviynrqqntqrfYLGHDDDILCLTIHPLKDYVATGqvGRDPSIHIWDTETIK 762
Cdd:cd00200   131 ----------------------------------------LRGHTDWVNSVAFSPDGTFVASS--SQDGTIKLWDLRTGK 168
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  763 PLSILKGhHQYGVSAVDFSADGKRLASVGIDDshTVVLWDWKKGEKLSIARGSKDKIFVVKMNPyvPDKLITAGIK--HM 840
Cdd:cd00200   169 CVATLTG-HTGEVNSVAFSPDGEKLLSSSSDG--TIKLWDLSTGKCLGTLRGHENGVNSVAFSP--DGYLLASGSEdgTI 243
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767979959  841 KFWRKAGDVCiwrdiflVKTVKAHDGPVFSM--HALEKGFVTGGKDGIVALWD 891
Cdd:cd00200   244 RVWDLRTGEC-------VQTLSGHTNSVTSLawSPDGKRLASGSADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
1317-1364 1.32e-14

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 70.27  E-value: 1.32e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 767979959  1317 KKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGdDIIYHTASVGILHNV 1364
Cdd:pfam03451   26 KKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1618-1879 2.90e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 2.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1618 VRSVC--RGKGKILVGTRNAEIIEVGEKNAACNILVNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVN 1695
Cdd:cd00200    12 VTCVAfsPDGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1696 lGHAA--RTVCYSPEGDMVAIGMKNGefiillvsSLKIW----GKK----RDRRCAIHDIRFSPDSRYLAVGSSENSVDF 1765
Cdd:cd00200    91 -GHTSyvSSVAFSPDGRILSSSSRDK--------TIKVWdvetGKClttlRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1766 YDLTLGPTLNRIsycKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKHLMD-HAAIDRITWATW-------TSIL 1837
Cdd:cd00200   162 WDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTlRGHENGVNSVAFspdgyllASGS 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767979959 1838 GDEVLGIWSRHAEK---------ADVNCACVSHSGISLVTGDDFGMVKLFD 1879
Cdd:cd00200   239 EDGTIRVWDLRTGEcvqtlsghtNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1651-1907 4.32e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 4.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1651 VNGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLnKVNLGHAA--RTVCYSPEGDMVAIGMKNGefiillvsS 1728
Cdd:cd00200     5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL-RTLKGHTGpvRDVAASADGTYLASGSSDK--------T 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1729 LKIWgKKRDRRC---------AIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDipsFVIQMDFSADSSYl 1799
Cdd:cd00200    75 IRLW-DLETGECvrtltghtsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTF- 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1800 qVSSGCYKR--HVYEVPSGKHLMDHaaidritwatwtsilgdevlgiwsrHAEKADVNCACVSHSGISLVTGDDFGMVKL 1877
Cdd:cd00200   150 -VASSSQDGtiKLWDLRTGKCVATL-------------------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203
                         250       260       270
                  ....*....|....*....|....*....|....
gi 767979959 1878 FDFPCPEKFVSLC----FVYYYQFTPNFDVLSSA 1907
Cdd:cd00200   204 WDLSTGKCLGTLRghenGVNSVAFSPDGYLLASG 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
46-178 3.50e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959   46 VYSPREHR-QKFYRGHSDDIISLALHPERVLVATGQVGKEpyICIWDSYTVQTISVLKdVHTHGIACLAFDLDGQRLVSV 124
Cdd:cd00200   161 LWDLRTGKcVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT--IKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASG 237
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767979959  125 GLDSKnaVCVWDWKRGKMLSMAPGHTDRIFDISWDlYQPNKLVSCGV-KHIKFWS 178
Cdd:cd00200   238 SEDGT--IRVWDLRTGECVQTLSGHTNSVTSLAWS-PDGKRLASGSAdGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
1703-1785 1.43e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.35  E-value: 1.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  1703 VCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRR-CAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCK 1781
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDKEdLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80

                   ....
gi 767979959  1782 DIPS 1785
Cdd:pfam12894   81 DLIT 84
WD40 COG2319
WD40 repeat [General function prediction only];
1663-1879 1.87e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1663 ATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVC-YSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCA 1741
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLaASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1742 IHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRIsycKDIPSFVIQMDFSADSSYLqVSSGCYKR-HVYEVPSGKH-- 1818
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTL-ASGSADGTvRLWDLATGKLlr 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767979959 1819 -LMDHA-AIDRITWA----TWTSILGDEVLGIWSRHAEK---------ADVNCACVSHSGISLVTGDDFGMVKLFD 1879
Cdd:COG2319   157 tLTGHSgAVTSVAFSpdgkLLASGSDDGTVRLWDLATGKllrtltghtGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 pfam00400
WD domain, G-beta repeat;
1652-1684 3.00e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 3.00e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767979959  1652 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1684
Cdd:pfam00400    8 EGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
760-802 3.71e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767979959    760 TIKPLSILKGHHQYgVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:smart00320    1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
1652-1684 4.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 4.06e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767979959   1652 NGHvDGPIWGLATHPSRDFFLSAAEDGTVRLWD 1684
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
314-353 1.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.24e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767979959   314 NKPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:pfam00400    1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
250-354 1.97e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.60  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959  250 FATGGRDGCIRLWDLTF--KPITVIDLRETdqGYKGLSVRSvcwRGDHILVGTQDSEIFEIVVQErNKPFLIMQGHCEGE 327
Cdd:cd22857   195 IVTGTGYHQVRLYDTRAqrRPVVSVDFGET--PIKAVAEDP---DGHTVYVGDTSGDLASIDLRT-GKLLGCFKGKCGGS 268
                          90       100
                  ....*....|....*....|....*..
gi 767979959  328 LWALAVHPTKPLAVTGSDDRSVRIWSL 354
Cdd:cd22857   269 IRSIARHPELPLIASCGLDRYLRIWDT 295
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
315-353 2.12e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 2.12e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 767979959    315 KPFLIMQGHcEGELWALAVHPTKPLAVTGSDDRSVRIWS 353
Cdd:smart00320    3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
956-988 3.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 3.05e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 767979959    956 QGHmEGEVWGLATHPYLPICATVSDDKTLRIWD 988
Cdd:smart00320    9 KGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
762-802 4.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 4.58e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767979959   762 KPLSILKGHHQyGVSAVDFSADGKRLASVGIDdsHTVVLWD 802
Cdd:pfam00400    2 KLLKTLEGHTG-SVTSLAFSPDGKLLASGSDD--GTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1660-1770 9.54e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 9.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1660 WGLATHPSRDF-FLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVS-----SLKIWg 1733
Cdd:COG3391   113 RGLAVDPDGGRlYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVSVIVSvidtaTGKVV- 191
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767979959 1734 KKRDRRCAIHDIRFSPDSRYLAVGSSE-NSVDFYDLTL 1770
Cdd:COG3391   192 ATIPVGGGPVGVAVSPDGRRLYVANRGsNTSNGGSNTV 229
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1671-1804 9.98e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 9.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979959 1671 FLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAI-GMKNGEFIILLVSSLKIWGKkrdrrcaI------H 1743
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVaDSGNGRVSVIDTATGKVVAT-------IpvgagpH 155
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767979959 1744 DIRFSPDSRYLAVGSSENS-----VDFYDLTLGPTLNRIsyckDIPSFVIQMDFSADSSYLQVSSG 1804
Cdd:COG3391   156 GIAVDPDGKRLYVANSGSNtvsviVSVIDTATGKVVATI----PVGGGPVGVAVSPDGRRLYVANR 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH