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Conserved domains on  [gi|767980172|ref|XP_011534912|]
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kelch domain-containing protein 2 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-269 4.41e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 88.29  E-value: 4.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172   6 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 85
Cdd:COG3055    3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  86 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 165
Cdd:COG3055   74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 166 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFTTD--------------------------- 218
Cdd:COG3055  132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGRNGSgfsntwttlaplptaraghaaavlggk 208

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767980172 219 -------KQPLSDAWTYCISKNEWIQFNHpyTEKPRLWHTACASDeGEVIVFGGCANN 269
Cdd:COG3055  209 ilvfggeSGFSDEVEAYDPATNTWTALGE--LPTPRHGHAAVLTD-GKVYVIGGETKP 263
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-269 4.41e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 88.29  E-value: 4.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172   6 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 85
Cdd:COG3055    3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  86 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 165
Cdd:COG3055   74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 166 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFTTD--------------------------- 218
Cdd:COG3055  132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGRNGSgfsntwttlaplptaraghaaavlggk 208

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767980172 219 -------KQPLSDAWTYCISKNEWIQFNHpyTEKPRLWHTACASDeGEVIVFGGCANN 269
Cdd:COG3055  209 ilvfggeSGFSDEVEAYDPATNTWTALGE--LPTPRHGHAAVLTD-GKVYVIGGETKP 263
PLN02193 PLN02193
nitrile-specifier protein
 59-241 3.97e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.82  E-value: 3.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  59 QWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYgYLPEDKVlgtfefdetsfwnsshprgwNDHVHILDTETFTWSQPIT 138
Cdd:PLN02193 152 KWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGE-FTPNQPI--------------------DKHLYVFDLETRTWSISPA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 139 TGKAPSPRAAHAC-ATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTpVSSDHLFLFGGFT- 216
Cdd:PLN02193 211 TGDVPHLSCLGVRmVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMA-ADEENVYVFGGVSa 289

                        170       180
                 ....*....|....*....|....*
gi 767980172 217 TDKQPLSDAwtYCISKNEWIQFNHP 241
Cdd:PLN02193 290 TARLKTLDS--YNIVDKKWFHCSTP 312
Kelch_4 pfam13418
Galactose oxidase, central domain;
195-235 1.07e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.61  E-value: 1.07e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767980172  195 GRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW 235
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-269 4.41e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 88.29  E-value: 4.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172   6 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 85
Cdd:COG3055    3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  86 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 165
Cdd:COG3055   74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 166 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFTTD--------------------------- 218
Cdd:COG3055  132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGRNGSgfsntwttlaplptaraghaaavlggk 208

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767980172 219 -------KQPLSDAWTYCISKNEWIQFNHpyTEKPRLWHTACASDeGEVIVFGGCANN 269
Cdd:COG3055  209 ilvfggeSGFSDEVEAYDPATNTWTALGE--LPTPRHGHAAVLTD-GKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
132-273 4.90e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 76.73  E-value: 4.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 132 TWSqpiTTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFL 211
Cdd:COG3055    2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP---LPGPPRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767980172 212 FGGFTTDK---QPLSDAWTYCISKNEWIQfnHPYTEKPRLWHTAcASDEGEVIVFGGCANNLLVH 273
Cdd:COG3055   76 FGGFTGANpssTPLNDVYVYDPATNTWTK--LAPMPTPRGGATA-LLLDGKIYVVGGWDDGGNVA 137
PLN02193 PLN02193
nitrile-specifier protein
 59-241 3.97e-11

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 63.82  E-value: 3.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  59 QWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYgYLPEDKVlgtfefdetsfwnsshprgwNDHVHILDTETFTWSQPIT 138
Cdd:PLN02193 152 KWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGE-FTPNQPI--------------------DKHLYVFDLETRTWSISPA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 139 TGKAPSPRAAHAC-ATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTpVSSDHLFLFGGFT- 216
Cdd:PLN02193 211 TGDVPHLSCLGVRmVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMA-ADEENVYVFGGVSa 289

                        170       180
                 ....*....|....*....|....*
gi 767980172 217 TDKQPLSDAwtYCISKNEWIQFNHP 241
Cdd:PLN02193 290 TARLKTLDS--YNIVDKKWFHCSTP 312
PLN02193 PLN02193
nitrile-specifier protein
 1-224 1.04e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 62.28  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172   1 METGRWKKINTEGDVPP-SMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTdrvlQWERIDC--QGIPPSS----- 72
Cdd:PLN02193 200 LETRTWSISPATGDVPHlSCLGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTN----EWKLLTPveEGPTPRSfhsma 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  73 KDKLGVWVyknklifFGGYGYLPEDKVLGTFEFDETSFWNSSHP----------------------RGWN----DHVHIL 126
Cdd:PLN02193 276 ADEENVYV-------FGGVSATARLKTLDSYNIVDKKWFHCSTPgdsfsirggaglevvqgkvwvvYGFNgcevDDVHYY 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 127 DTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGryrDARMNDLHY------------LNLDTWEWNELIPQGI--- 191
Cdd:PLN02193 349 DPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG---EIAMDPLAHvgpgqltdgtfaLDTETLQWERLDKFGEeee 425

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 767980172 192 CPVGRSWHSLTPVSSD---HLFLFGGfttdKQPLSD 224
Cdd:PLN02193 426 TPSSRGWTASTTGTIDgkkGLVMHGG----KAPTND 457
PLN02153 PLN02153
epithiospecifier protein
 140-265 7.95e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 59.23  E-value: 7.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 140 GKAPSPRAAHACATVGNRGFVFGGRYRDARM--NDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGfTT 217
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGELKPNEHidKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGG-RD 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767980172 218 DKQPLSDAWTYCISKNEW---IQFNHPYTEKPRLWHTAcASDEGEVIVFGG 265
Cdd:PLN02153  96 EKREFSDFYSYDTVKNEWtflTKLDEEGGPEARTFHSM-ASDENHVYVFGG 145
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-226 2.54e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.09  E-value: 2.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172   3 TGRWKKInteGDVP-PSMSGSCAVCVDRVLYLFGG----HHSRGNTNKFYMLDSrSTDRvlqWERIdcqGIPPSSKDKLG 77
Cdd:COG3055   47 TNTWSEL---APLPgPPRHHAAAVAQDGKLYVFGGftgaNPSSTPLNDVYVYDP-ATNT---WTKL---APMPTPRGGAT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  78 VWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSfW----NSSHPRGW-------NDHVHIL--DTETFTWSQPITTGKAPS 144
Cdd:COG3055  117 ALLLDGKIYVVGGWDDGGNVAWVEVYDPATGT-WtqlaPLPTPRDHlaaavlpDGKILVIggRNGSGFSNTWTTLAPLPT 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 145 PRAAHACATVGNRGFVFGGRYrdARMNDLHYLNLDTWEWNELipqGICPVGRswHSLTPVS-SDHLFLFGGFTTDKQPLS 223
Cdd:COG3055  196 ARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTAL---GELPTPR--HGHAAVLtDGKVYVIGGETKPGVRTP 268


                 ...
gi 767980172 224 DAW 226
Cdd:COG3055  269 LVT 271
PLN02153 PLN02153
epithiospecifier protein
 3-231 9.52e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 56.15  E-value: 9.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172   3 TGRWKKINTEGDVPP-SMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTdrvlQWE---RIDCQGIPPS------S 72
Cdd:PLN02153  59 THTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDEKREFSDFYSYDTVKN----EWTfltKLDEEGGPEArtfhsmA 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172  73 KDKLGVWVY----KNKL--------------IFFGGYGYLP------EDKVLGTFEFDETSFW------NSSHPRGWNDH 122
Cdd:PLN02153 135 SDENHVYVFggvsKGGLmktperfrtieaynIADGKWVQLPdpgenfEKRGGAGFAVVQGKIWvvygfaTSILPGGKSDY 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 123 ----VHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGR-YRDAR--------MNDLHYLNLDTWEWNELIPQ 189
Cdd:PLN02153 215 esnaVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGGEvWPDLKghlgpgtlSNEGYALDTETLVWEKLGEC 294

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 767980172 190 GICPVGRSWHSLTPVSSD---HLFLFGGFTTDKQPLSDAWTYCIS 231
Cdd:PLN02153 295 GEPAMPRGWTAYTTATVYgknGLLMHGGKLPTNERTDDLYFYAVN 339
PLN02193 PLN02193
nitrile-specifier protein
 133-265 6.00e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.81  E-value: 6.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172 133 WSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMND--LHYLNLDTWEWNELIPQGICPvGRSWHSLTPVS-SDHL 209
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDkhLYVFDLETRTWSISPATGDVP-HLSCLGVRMVSiGSTL 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767980172 210 FLFGGFTTDKQpLSDAWTYCISKNEWiQFNHPYTE--KPRLWHTAcASDEGEVIVFGG 265
Cdd:PLN02193 232 YVFGGRDASRQ-YNGFYSFDTTTNEW-KLLTPVEEgpTPRSFHSM-AADEENVYVFGG 286
Kelch_4 pfam13418
Galactose oxidase, central domain;
195-235 1.07e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.61  E-value: 1.07e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767980172  195 GRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW 235
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
Kelch_3 pfam13415
Galactose oxidase, central domain;
207-254 8.52e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 8.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767980172  207 DHLFLFGGFTTDKQP-LSDAWTYCISKNEWIQFNHPYTekPRLWHTACA 254
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPP--PRSGHSATY 48
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 145-186 1.69e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 1.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767980172  145 PRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNEL 186
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
Kelch_3 pfam13415
Galactose oxidase, central domain;
155-202 1.24e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767980172  155 GNRGFVFGGRYRDA--RMNDLHYLNLDTWEWNELipqGICPVGRSWHSLT 202
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSAT 47
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 16-50 5.41e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.08  E-value: 5.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767980172   16 PPSMSGSCAVCVDRVLYLFGGHHSRGN--TNKFYMLD 50
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGqpSDDVYVLS 37
PHA03098 PHA03098
kelch-like protein; Provisional
 2-132 7.19e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 38.21  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980172   2 ETGRWKKINTegdVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTdRVLQWERIDCQGIPpssKDKLGVWVY 81
Cdd:PHA03098 414 NTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVESYNP-VTNKWTELSSLNFP---RINASLCIF 486

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767980172  82 KNKLIFFGGYGYLPEDKVLGTFEfDETSFWNSSHprGWNDHVHILDTETFT 132
Cdd:PHA03098 487 NNKIYVVGGDKYEYYINEIEVYD-DKTNTWTLFC--KFPKVIGSLEKNIFT 534
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 193-230 8.77e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 8.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767980172  193 PVGRSWHSLTpVSSDHLFLFGGFT-TDKQPLSDAWTYCI 230
Cdd:pfam13854   1 PVPRYGHCAV-TVGDYIYLYGGYTgGEGQPSDDVYVLSL 38
Kelch_6 pfam13964
Kelch motif;
145-186 9.55e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 33.85  E-value: 9.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767980172  145 PRAAHACATVGNRGFVFGGRYRDA-RMNDLHYLNLDTWEWNEL 186
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASpALNKLEVYNPLTKSWEEL 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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