P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981583   65 GVKQVIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSM 144
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALARLG--YKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSI 78

                          90       100
                  ....*....|....*....|....*...
gi 767981583  145 GFLVE-ESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:pfam10609  79 GFLLPdEDDAVIWRGPMKSGAIKQFLTD 106

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981583   65 GVKQVIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSM 144
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALARLG--YKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSI 78

                          90       100
                  ....*....|....*....|....*...
gi 767981583  145 GFLVE-ESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:pfam10609  79 GFLLPdEDDAVIWRGPMKSGAIKQFLTD 106

iron-sulfur cluster carrier protein ApbC;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981583  60 QKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSkaIGLLDVDVYGPSVPKMMNLKGNPELSQSNL-MRPLLNYG 138
Cdd:PRK11670 100 QPGVNGVKNIIAVSSGKGGVGKSSTAVNLALALAAEGAK--VGILDADIYGPSIPTMLGAEDQRPTSPDGThMAPIMAHG 177

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767981583 139 IACMSMGFLVEESEPVVWRGLMVMSAIEKLL 169
Cdd:PRK11670 178 LATNSIGYLVTDDNAMVWRGPMASKALMQML 208

septum site-determining protein MinD; This model describes the bacterial and chloroplast form of MinD, a multifunctional cell division protein that guides correct placement of the septum. The homologous archaeal MinD proteins, with many archaeal genomes having two or more forms, are described by a separate model. [Cellular processes, Cell division]

                          10
                  ....*....|....*....
gi 767981583   69 VIVVASGKGGVGKSTTAVN 87
Cdd:TIGR01968   3 VIVITSGKGGVGKTTTTAN 21

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981583   65 GVKQVIVVASGKGGVGKSTTAVNLALALAANDssKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSM 144
Cdd:pfam10609   1 GVKHVIAVASGKGGVGKSTVAVNLALALARLG--YKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSI 78

                          90       100
                  ....*....|....*....|....*...
gi 767981583  145 GFLVE-ESEPVVWRGLMVMSAIEKLLRQ 171
Cdd:pfam10609  79 GFLLPdEDDAVIWRGPMKSGAIKQFLTD 106

iron-sulfur cluster carrier protein ApbC;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767981583  60 QKPIEGVKQVIVVASGKGGVGKSTTAVNLALALAANDSSkaIGLLDVDVYGPSVPKMMNLKGNPELSQSNL-MRPLLNYG 138
Cdd:PRK11670 100 QPGVNGVKNIIAVSSGKGGVGKSSTAVNLALALAAEGAK--VGILDADIYGPSIPTMLGAEDQRPTSPDGThMAPIMAHG 177

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767981583 139 IACMSMGFLVEESEPVVWRGLMVMSAIEKLL 169
Cdd:PRK11670 178 LATNSIGYLVTDDNAMVWRGPMASKALMQML 208

partition proteins ParAB family; ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single-stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis. ParA shares sequence similarity to a conserved and widespread family of ATPases which includes the repA protein of the repABC operon in Rhizobium etli symbiotic plasmid. This operon is involved in the plasmid replication and partition.

                         10
                 ....*....|....*....
gi 767981583  69 VIVVASGKGGVGKSTTAVN 87
Cdd:cd02042    2 VIAVANQKGGVGKTTLAVN 20

Septum site-determining ATPase MinD [Cell cycle control, cell division, chromosome partitioning];

                         10        20
                 ....*....|....*....|
gi 767981583  68 QVIVVASGKGGVGKSTTAVN 87
Cdd:COG2894    3 KVIVVTSGKGGVGKTTTTAN 22

septum site-determining protein MinD; Septum site-determining protein MinD is part of the operon MinCDE that determines the site of the formation of a septum at mid-cell, an important part of bacterial cell division. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal role, selecting the mid-cell over other sites through the activation and regulation of MinC and MinE. MinD is a membrane-associated ATPase, related to nitrogenase iron protein.

                         10
                 ....*....|....*....
gi 767981583  69 VIVVASGKGGVGKSTTAVN 87
Cdd:cd02036    2 VIVITSGKGGVGKTTTTAN 20

AAA domain; This family includes a wide variety of AAA domains including some that have lost essential nucleotide binding residues in the P-loop.

                          10        20
                  ....*....|....*....|
gi 767981583   68 QVIVVASGKGGVGKSTTAVN 87
Cdd:pfam13614   2 KVIAIANQKGGVGKTTTSVN 21

septum site-determining protein MinD; This model describes the bacterial and chloroplast form of MinD, a multifunctional cell division protein that guides correct placement of the septum. The homologous archaeal MinD proteins, with many archaeal genomes having two or more forms, are described by a separate model. [Cellular processes, Cell division]

                          10
                  ....*....|....*....
gi 767981583   69 VIVVASGKGGVGKSTTAVN 87
Cdd:TIGR01968   3 VIVITSGKGGVGKTTTTAN 21

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767981583  70 IVVASGKGGVGKSTTAVNLALalaandSSKAIGLLDVDVYGPSVPKMMNLKGNPE 124
Cdd:cd03110    2 IAVLSGKGGTGKTTITANLAV------LLYNVILVDCDVDAPNLHLLLGPEPEEE 50