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Conserved domains on  [gi|767974773|ref|XP_011536841|]
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stabilin-2 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 1641-1733 4.87e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


:

Pssm-ID: 239592  Cd Length: 93  Bit Score: 178.04  E-value: 4.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1641 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1720
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 767974773 1721 RPNKSEMWDVFCY 1733
Cdd:cd03515    81 RLNLSERWDAYCY 93
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 452-572 1.09e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 109.65  E-value: 1.09e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   452 IFNRWINNASLQPTLSAT-SNLTVLVPSQQATEDMDQDEKSFWLSQSN-IPALIKYHMLLGTYRVADLQTLSSsdmlATS 529
Cdd:pfam02469    5 TFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLLKDKEqLKNLLKYHVVPGRLTSSDLKNGGT----LAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767974773   530 LQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 572
Cdd:pfam02469   81 LQGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1060-1169 3.74e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1060 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 1135
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 767974773  1136 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 1169
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1195-1325 3.78e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.78e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1195 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 1274
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767974773  1275 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 1325
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 591-708 3.65e-22

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 93.86  E-value: 3.65e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   591 PDYSIFRGYIIQYNLANAIEAADA-YTVFAPNNNAIENYIRE-----KKVLSLEEDVLRYHVVlEEKLLKNDLHNGMHRE 664
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKLPAGtlnflLKDKEQLKNLLKYHVV-PGRLTSSDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 767974773   665 TMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 708
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1799-1892 3.01e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


:

Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.17  E-value: 3.01e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1799 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPlqptETRFVDGR 1868
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 767974773   1869 AILQWDIFASNGIIHVISRPLKAP 1892
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 918-954 7.97e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 7.97e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   918 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 954
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
Fasciclin super family cl02663
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 19-97 2.52e-07

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


The actual alignment was detected with superfamily member pfam02469:

Pssm-ID: 470649  Cd Length: 123  Bit Score: 51.10  E-value: 2.52e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974773    19 ILQGSRKLLELVRYHIVPfTQLEVATLISTPHIRSMANQLIQFNTTdNGQILANDVAMEEIEITAKNGRIYTLTGVLIP 97
Cdd:pfam02469   47 LLKDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVT-GGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1570-1607 2.90e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.36  E-value: 2.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767974773  1570 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 1607
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1002-1038 6.11e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 6.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773  1002 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 1038
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 280-308 4.47e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 4.47e-06
                           10        20
                   ....*....|....*....|....*....
gi 767974773   280 CHIHATCEYSNGTASCICKAGYEGDGTLC 308
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 960-996 1.65e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 1.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   960 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 996
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1529-1564 4.03e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 4.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767974773  1529 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 1564
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 400-436 2.43e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.27  E-value: 2.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   400 CLEQTGKCHPLASCQSTSSGVwSCVCQEGYEGDGFLC 436
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 880-912 4.47e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.50  E-value: 4.47e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974773   880 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 912
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 319-351 6.50e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 6.50e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974773   319 PGGCSRNAECIKTGtGTHTCVCQQGWTGNGRDC 351
Cdd:pfam12947    5 NGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 363-394 1.51e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.51e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767974773   363 GGCHDNASCLYVgPGQNECECKKGFRGNGIDC 394
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 1641-1733 4.87e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 178.04  E-value: 4.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1641 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1720
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 767974773 1721 RPNKSEMWDVFCY 1733
Cdd:cd03515    81 RLNLSERWDAYCY 93
Xlink pfam00193
Extracellular link domain;
1641-1733 3.09e-37

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 135.39  E-value: 3.09e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1641 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1720
Cdd:pfam00193    1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 767974773  1721 RPNKSEMWDVFCY 1733
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 452-572 1.09e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 109.65  E-value: 1.09e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   452 IFNRWINNASLQPTLSAT-SNLTVLVPSQQATEDMDQDEKSFWLSQSN-IPALIKYHMLLGTYRVADLQTLSSsdmlATS 529
Cdd:pfam02469    5 TFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLLKDKEqLKNLLKYHVVPGRLTSSDLKNGGT----LAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767974773   530 LQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 572
Cdd:pfam02469   81 LQGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1060-1169 3.74e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1060 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 1135
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 767974773  1136 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 1169
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1195-1325 3.78e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.78e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1195 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 1274
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767974773  1275 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 1325
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
LINK smart00445
Link (Hyaluronan-binding);
1641-1734 1.07e-26

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 105.50  E-value: 1.07e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1641 GVFHLRsPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGp 1720
Cdd:smart00445    3 GVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQYG- 80

                            90
                    ....*....|....
gi 767974773   1721 RPNKSEMWDVFCYR 1734
Cdd:smart00445   81 FPDPTSRYDAYCFN 94
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1064-1169 8.27e-24

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 99.98  E-value: 8.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1064 VKDLVGPGPFTVFAPLSAAFDE--EARVKDWDK---YGLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQS 1138
Cdd:COG2335    56 VDTLSGEGPFTVFAPTDAAFAAlpAGTLDALLKpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGG 134

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767974773 1139 TVYINNkAKIISSDIISTNGIVHIIDKLLSP 1169
Cdd:COG2335   135 GVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1074-1170 2.52e-22

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 93.20  E-value: 2.52e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1074 TVFAPLSAAFDE-EARVKDWDKYgLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQ--STVYINNkAKIIS 1150
Cdd:smart00554    1 TVFAPTDEAFQKlPPDLNSLLAD-KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVE 77

                            90       100
                    ....*....|....*....|
gi 767974773   1151 SDIISTNGIVHIIDKLLSPK 1170
Cdd:smart00554   78 ADIAATNGVVHVIDRVLLPP 97
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 591-708 3.65e-22

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 93.86  E-value: 3.65e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   591 PDYSIFRGYIIQYNLANAIEAADA-YTVFAPNNNAIENYIRE-----KKVLSLEEDVLRYHVVlEEKLLKNDLHNGMHRE 664
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKLPAGtlnflLKDKEQLKNLLKYHVV-PGRLTSSDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 767974773   665 TMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 708
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 443-572 4.32e-21

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 91.89  E-value: 4.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  443 ELSFLSEAaifnrwINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPAL---IKYHMLLGTYRVADLQT 519
Cdd:COG2335    42 DFSTLVAA------LKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPENKATLtkiLTYHVVPGKVTAADLKD 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767974773  520 LSSsdmlATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 572
Cdd:COG2335   116 GKT----LTTLQGQTLTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1221-1327 3.15e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.64  E-value: 3.15e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1221 TLFWPTDQALHALPAEQQDFLfnqdnKDKLKEYLKFHVIRDaKVLAVDLPTSTAWKTLQGSELSVKCgaGRDIGDLFLNG 1300
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR--SGGSGTVTVNG 72

                            90       100
                    ....*....|....*....|....*..
gi 767974773   1301 QtcRIVQRELLFDLGVAYGIDCLLIDP 1327
Cdd:smart00554   73 A--RIVEADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1185-1325 1.86e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.79  E-value: 1.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1185 QNLTTLATNNGyiKFSNL---IQDSGLLSVITDPihTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIrD 1261
Cdd:COG2335    31 KNIVETAANNP--DFSTLvaaLKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVV-P 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974773 1262 AKVLAVDLPTSTAWKTLQGSELSVKcgagRDIGDLFLNGQTcrIVQRELLFDLGVAYGIDCLLI 1325
Cdd:COG2335   106 GKVTAADLKDGKTLTTLQGQTLTVT----VSGGGVTVNGAN--VITADIEASNGVIHVIDKVLL 163
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
473-572 1.15e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 74.32  E-value: 1.15e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773    473 TVLVPSQQATEDMDQDEKSFWLSQsnIPALIKYHMLLGTYRVADLQtlssSDMLATSLQGN--FLHLAKVDGNITIEGAS 550
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADK--LKNLLLYHVVPGRLSSADLL----NGGTLPTLAGSklRITRSGGSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|..
gi 767974773    551 IVDGDNAATNGVIHIINKVLVP 572
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLP 96
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 581-708 2.07e-15

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 75.71  E-value: 2.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  581 PNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIrEKKVLSLEED--------VLRYHVVlEEKL 652
Cdd:COG2335    31 KNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALP-AGTLDALLKPenkatltkILTYHVV-PGKV 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767974773  653 LKNDLHNGMHRETMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 708
Cdd:COG2335   109 TAADLKDGKTLTTLQGQT--LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVL 162
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1799-1892 3.01e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.17  E-value: 3.01e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1799 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPlqptETRFVDGR 1868
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 767974773   1869 AILQWDIFASNGIIHVISRPLKAP 1892
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
616-708 8.90e-12

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 63.15  E-value: 8.90e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773    616 TVFAPNNNAIENYIREKKVLSLE--EDVLRYHVVlEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTN 693
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADklKNLLLYHVV-PGRLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 767974773    694 VATDKGVIHGLGKVL 708
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 918-954 7.97e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 7.97e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   918 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 954
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1799-1889 9.38e-08

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 52.64  E-value: 9.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1799 TLFVPQNSGLGE------NETLSGRD-----IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLqptetrFVDG 1867
Cdd:pfam02469   27 TVFAPTNEAFAKlpagtlNFLLKDKEqlknlLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVTGGSV------TVNG 99

                           90       100
                   ....*....|....*....|..
gi 767974773  1868 RAILQWDIFASNGIIHVISRPL 1889
Cdd:pfam02469  100 ARVVQADIEATNGVIHVIDKVL 121
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 19-97 2.52e-07

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 51.10  E-value: 2.52e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974773    19 ILQGSRKLLELVRYHIVPfTQLEVATLISTPHIRSMANQLIQFNTTdNGQILANDVAMEEIEITAKNGRIYTLTGVLIP 97
Cdd:pfam02469   47 LLKDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVT-GGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1570-1607 2.90e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.36  E-value: 2.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767974773  1570 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 1607
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1002-1038 6.11e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 6.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773  1002 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 1038
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1738-1889 4.43e-06

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 48.75  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1738 VNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNfLTEVLAYSNssargraflehLTD-LSIRG--TLFVPQNS-----GLG 1809
Cdd:COG2335    14 AACASSAAAEGAAMAPTKNIVETAANNPDFST-LVAALKAAG-----------LVDtLSGEGpfTVFAPTDAafaalPAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1810 ENETLSG-------RDI-EHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLQptetrfVDGRAILQWDIFASNGI 1881
Cdd:COG2335    82 TLDALLKpenkatlTKIlTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT------VNGANVITADIEASNGV 154


                  ....*...
gi 767974773 1882 IHVISRPL 1889
Cdd:COG2335   155 IHVIDKVL 162
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 280-308 4.47e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 4.47e-06
                           10        20
                   ....*....|....*....|....*....
gi 767974773   280 CHIHATCEYSNGTASCICKAGYEGDGTLC 308
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
25-98 8.76e-06

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 46.20  E-value: 8.76e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767974773     25 KLLELVRYHIVPfTQLEVATLISTPHIRSMANQLIQFNTT-DNGQILANDVAMEEIEITAKNGRIYTLTGVLIPP 98
Cdd:smart00554   24 KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSgGSGTVTVNGARIVEADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 960-996 1.65e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 1.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   960 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 996
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1529-1564 4.03e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 4.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767974773  1529 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 1564
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 400-436 2.43e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.27  E-value: 2.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   400 CLEQTGKCHPLASCQSTSSGVwSCVCQEGYEGDGFLC 436
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 25-97 2.61e-04

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 43.74  E-value: 2.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767974773   25 KLLELVRYHIVPfTQLEVATLISTPHIRSMANQLIQFnTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIP 97
Cdd:COG2335    94 TLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTV-TVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 880-912 4.47e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.50  E-value: 4.47e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974773   880 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 912
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 319-351 6.50e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 6.50e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974773   319 PGGCSRNAECIKTGtGTHTCVCQQGWTGNGRDC 351
Cdd:pfam12947    5 NGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 363-394 1.51e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.51e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767974773   363 GGCHDNASCLYVgPGQNECECKKGFRGNGIDC 394
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 1641-1733 4.87e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 178.04  E-value: 4.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1641 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1720
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 767974773 1721 RPNKSEMWDVFCY 1733
Cdd:cd03515    81 RLNLSERWDAYCY 93
Xlink pfam00193
Extracellular link domain;
1641-1733 3.09e-37

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 135.39  E-value: 3.09e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1641 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1720
Cdd:pfam00193    1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 767974773  1721 RPNKSEMWDVFCY 1733
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 452-572 1.09e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 109.65  E-value: 1.09e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   452 IFNRWINNASLQPTLSAT-SNLTVLVPSQQATEDMDQDEKSFWLSQSN-IPALIKYHMLLGTYRVADLQTLSSsdmlATS 529
Cdd:pfam02469    5 TFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLLKDKEqLKNLLKYHVVPGRLTSSDLKNGGT----LAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767974773   530 LQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 572
Cdd:pfam02469   81 LQGSKLRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1060-1169 3.74e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.74e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1060 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 1135
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 767974773  1136 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 1169
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1195-1325 3.78e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 3.78e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1195 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 1274
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767974773  1275 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 1325
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
LINK smart00445
Link (Hyaluronan-binding);
1641-1734 1.07e-26

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 105.50  E-value: 1.07e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1641 GVFHLRsPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGp 1720
Cdd:smart00445    3 GVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQYG- 80

                            90
                    ....*....|....
gi 767974773   1721 RPNKSEMWDVFCYR 1734
Cdd:smart00445   81 FPDPTSRYDAYCFN 94
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1064-1169 8.27e-24

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 99.98  E-value: 8.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1064 VKDLVGPGPFTVFAPLSAAFDE--EARVKDWDK---YGLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQS 1138
Cdd:COG2335    56 VDTLSGEGPFTVFAPTDAAFAAlpAGTLDALLKpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGG 134

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767974773 1139 TVYINNkAKIISSDIISTNGIVHIIDKLLSP 1169
Cdd:COG2335   135 GVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 1641-1733 1.17e-23

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 96.72  E-value: 1.17e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1641 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 1720
Cdd:cd01102     1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGRNPGVRSYGN 80

                          90
                  ....*....|...
gi 767974773 1721 rPNKSEMWDVFCY 1733
Cdd:cd01102    81 -PAPSGRYDAYCF 92
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1074-1170 2.52e-22

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 93.20  E-value: 2.52e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1074 TVFAPLSAAFDE-EARVKDWDKYgLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQ--STVYINNkAKIIS 1150
Cdd:smart00554    1 TVFAPTDEAFQKlPPDLNSLLAD-KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVE 77

                            90       100
                    ....*....|....*....|
gi 767974773   1151 SDIISTNGIVHIIDKLLSPK 1170
Cdd:smart00554   78 ADIAATNGVVHVIDRVLLPP 97
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 591-708 3.65e-22

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 93.86  E-value: 3.65e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   591 PDYSIFRGYIIQYNLANAIEAADA-YTVFAPNNNAIENYIRE-----KKVLSLEEDVLRYHVVlEEKLLKNDLHNGMHRE 664
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKLPAGtlnflLKDKEQLKNLLKYHVV-PGRLTSSDLKNGGTLA 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 767974773   665 TMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 708
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVL 121
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 443-572 4.32e-21

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 91.89  E-value: 4.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  443 ELSFLSEAaifnrwINNASLQPTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPAL---IKYHMLLGTYRVADLQT 519
Cdd:COG2335    42 DFSTLVAA------LKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPENKATLtkiLTYHVVPGKVTAADLKD 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767974773  520 LSSsdmlATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVP 572
Cdd:COG2335   116 GKT----LTTLQGQTLTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1221-1327 3.15e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.64  E-value: 3.15e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1221 TLFWPTDQALHALPAEQQDFLfnqdnKDKLKEYLKFHVIRDaKVLAVDLPTSTAWKTLQGSELSVKCgaGRDIGDLFLNG 1300
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR--SGGSGTVTVNG 72

                            90       100
                    ....*....|....*....|....*..
gi 767974773   1301 QtcRIVQRELLFDLGVAYGIDCLLIDP 1327
Cdd:smart00554   73 A--RIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 1642-1733 3.16e-17

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 78.60  E-value: 3.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1642 VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNC---GSGVVGIVDY 1718
Cdd:cd03517     2 VFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCygdMDGFPGVRNY 81

                          90
                  ....*....|....*
gi 767974773 1719 GPRpNKSEMWDVFCY 1733
Cdd:cd03517    82 GVR-DPDELYDVYCY 95
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 1642-1733 6.59e-17

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 77.85  E-value: 6.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1642 VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCG--SGVVGIVDYG 1719
Cdd:cd03518     2 VFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGgkRTVPGLRSYG 81

                          90
                  ....*....|....
gi 767974773 1720 PRPNKSEMWDVFCY 1733
Cdd:cd03518    82 ERDKMLSRYDAFCF 95
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1185-1325 1.86e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.79  E-value: 1.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1185 QNLTTLATNNGyiKFSNL---IQDSGLLSVITDPihTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIrD 1261
Cdd:COG2335    31 KNIVETAANNP--DFSTLvaaLKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVV-P 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974773 1262 AKVLAVDLPTSTAWKTLQGSELSVKcgagRDIGDLFLNGQTcrIVQRELLFDLGVAYGIDCLLI 1325
Cdd:COG2335   106 GKVTAADLKDGKTLTTLQGQTLTVT----VSGGGVTVNGAN--VITADIEASNGVIHVIDKVLL 163
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
473-572 1.15e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 74.32  E-value: 1.15e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773    473 TVLVPSQQATEDMDQDEKSFWLSQsnIPALIKYHMLLGTYRVADLQtlssSDMLATSLQGN--FLHLAKVDGNITIEGAS 550
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADK--LKNLLLYHVVPGRLSSADLL----NGGTLPTLAGSklRITRSGGSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|..
gi 767974773    551 IVDGDNAATNGVIHIINKVLVP 572
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLP 96
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 581-708 2.07e-15

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 75.71  E-value: 2.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  581 PNLLMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIrEKKVLSLEED--------VLRYHVVlEEKL 652
Cdd:COG2335    31 KNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALP-AGTLDALLKPenkatltkILTYHVV-PGKV 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767974773  653 LKNDLHNGMHRETMLGFSyfLSFFLHNDQLYVNEAPINYTNVATDKGVIHGLGKVL 708
Cdd:COG2335   109 TAADLKDGKTLTTLQGQT--LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVL 162
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1799-1892 3.01e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.17  E-value: 3.01e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773   1799 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPlqptETRFVDGR 1868
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 767974773   1869 AILQWDIFASNGIIHVISRPLKAP 1892
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 1642-1733 2.26e-13

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 67.72  E-value: 2.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1642 VFHLRSPlgqYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVG---IVDY 1718
Cdd:cd03520     2 VFYATAP---EKFTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGGLPGvrtLYRF 78

                          90
                  ....*....|....*...
gi 767974773 1719 GPR---PNKSEMWDVFCY 1733
Cdd:cd03520    79 PNQtgfPDPHSRFDAYCF 96
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 1641-1733 4.35e-12

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 63.98  E-value: 4.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1641 GVFHLRSPLgqyKLTFDKAREACANEAATMATYNQLSYAQK-AKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYG 1719
Cdd:cd03519     1 GVFYLLHPG---KLTFSEAVAACQRDGAQIAKVGQLFAAWKfHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFG 77

                          90
                  ....*....|....
gi 767974773 1720 PRPNKSEMWDVFCY 1733
Cdd:cd03519    78 FPDKKHKLYGVYCY 91
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
616-708 8.90e-12

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 63.15  E-value: 8.90e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773    616 TVFAPNNNAIENYIREKKVLSLE--EDVLRYHVVlEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTN 693
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADklKNLLLYHVV-PGRLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 767974773    694 VATDKGVIHGLGKVL 708
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 1641-1737 9.49e-10

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 59.01  E-value: 9.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1641 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYgp 1720
Cdd:cd03516     7 GVFLVEKN-GRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCGKNGTGVYIL-- 83

                          90
                  ....*....|....*..
gi 767974773 1721 RPNKSEMWDVFCYRMKD 1737
Cdd:cd03516    84 NSNLSSRYDAYCYNSSD 100
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 918-954 7.97e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 7.97e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   918 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 954
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1799-1889 9.38e-08

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 52.64  E-value: 9.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773  1799 TLFVPQNSGLGE------NETLSGRD-----IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLqptetrFVDG 1867
Cdd:pfam02469   27 TVFAPTNEAFAKlpagtlNFLLKDKEqlknlLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVTGGSV------TVNG 99

                           90       100
                   ....*....|....*....|..
gi 767974773  1868 RAILQWDIFASNGIIHVISRPL 1889
Cdd:pfam02469  100 ARVVQADIEATNGVIHVIDKVL 121
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 19-97 2.52e-07

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 51.10  E-value: 2.52e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974773    19 ILQGSRKLLELVRYHIVPfTQLEVATLISTPHIRSMANQLIQFNTTdNGQILANDVAMEEIEITAKNGRIYTLTGVLIP 97
Cdd:pfam02469   47 LLKDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVT-GGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1570-1607 2.90e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 48.36  E-value: 2.90e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767974773  1570 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 1607
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1002-1038 6.11e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 6.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773  1002 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 1038
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1738-1889 4.43e-06

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 48.75  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1738 VNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNfLTEVLAYSNssargraflehLTD-LSIRG--TLFVPQNS-----GLG 1809
Cdd:COG2335    14 AACASSAAAEGAAMAPTKNIVETAANNPDFST-LVAALKAAG-----------LVDtLSGEGpfTVFAPTDAafaalPAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974773 1810 ENETLSG-------RDI-EHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLQptetrfVDGRAILQWDIFASNGI 1881
Cdd:COG2335    82 TLDALLKpenkatlTKIlTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT------VNGANVITADIEASNGV 154


                  ....*...
gi 767974773 1882 IHVISRPL 1889
Cdd:COG2335   155 IHVIDKVL 162
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 280-308 4.47e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 44.90  E-value: 4.47e-06
                           10        20
                   ....*....|....*....|....*....
gi 767974773   280 CHIHATCEYSNGTASCICKAGYEGDGTLC 308
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
25-98 8.76e-06

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 46.20  E-value: 8.76e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767974773     25 KLLELVRYHIVPfTQLEVATLISTPHIRSMANQLIQFNTT-DNGQILANDVAMEEIEITAKNGRIYTLTGVLIPP 98
Cdd:smart00554   24 KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSgGSGTVTVNGARIVEADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 960-996 1.65e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.36  E-value: 1.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   960 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 996
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1529-1564 4.03e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.20  E-value: 4.03e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767974773  1529 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 1564
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 400-436 2.43e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.27  E-value: 2.43e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974773   400 CLEQTGKCHPLASCQSTSSGVwSCVCQEGYEGDGFLC 436
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSF-TCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 25-97 2.61e-04

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 43.74  E-value: 2.61e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767974773   25 KLLELVRYHIVPfTQLEVATLISTPHIRSMANQLIQFnTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIP 97
Cdd:COG2335    94 TLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTV-TVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 880-912 4.47e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.50  E-value: 4.47e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974773   880 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 912
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 319-351 6.50e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 6.50e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974773   319 PGGCSRNAECIKTGtGTHTCVCQQGWTGNGRDC 351
Cdd:pfam12947    5 NGGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 363-394 1.51e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.96  E-value: 1.51e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767974773   363 GGCHDNASCLYVgPGQNECECKKGFRGNGIDC 394
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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