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Conserved domains on  [gi|767974779|ref|XP_011536844|]
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stabilin-2 isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 885-977 4.42e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


:

Pssm-ID: 239592  Cd Length: 93  Bit Score: 177.27  E-value: 4.42e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  885 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 964
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 767974779  965 RPNKSEMWDVFCY 977
Cdd:cd03515    81 RLNLSERWDAYCY 93
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 304-413 2.28e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 2.28e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   304 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 379
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 767974779   380 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 413
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 439-569 2.30e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 2.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   439 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 518
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767974779   519 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 569
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1043-1136 1.84e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


:

Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.17  E-value: 1.84e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   1043 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPlqptETRFVDGR 1112
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 767974779   1113 AILQWDIFASNGIIHVISRPLKAP 1136
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 162-198 8.50e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.13  E-value: 8.50e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   162 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 198
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 814-851 3.22e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 3.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767974779   814 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 851
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 246-282 6.39e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 6.39e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   246 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 282
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 204-240 1.64e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.97  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   204 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 240
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 773-808 3.75e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 3.75e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767974779   773 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 808
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 124-156 4.28e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 4.28e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974779   124 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 156
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 885-977 4.42e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 177.27  E-value: 4.42e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  885 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 964
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 767974779  965 RPNKSEMWDVFCY 977
Cdd:cd03515    81 RLNLSERWDAYCY 93
Xlink pfam00193
Extracellular link domain;
885-977 3.78e-37

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 134.62  E-value: 3.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   885 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 964
Cdd:pfam00193    1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 767974779   965 RPNKSEMWDVFCY 977
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 304-413 2.28e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 2.28e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   304 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 379
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 767974779   380 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 413
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 439-569 2.30e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 2.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   439 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 518
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767974779   519 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 569
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
LINK smart00445
Link (Hyaluronan-binding);
885-978 1.26e-26

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 104.73  E-value: 1.26e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779    885 GVFHLRsPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGp 964
Cdd:smart00445    3 GVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQYG- 80

                            90
                    ....*....|....
gi 767974779    965 RPNKSEMWDVFCYR 978
Cdd:smart00445   81 FPDPTSRYDAYCFN 94
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 308-413 4.96e-24

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 99.98  E-value: 4.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  308 VKDLVGPGPFTVFAPLSAAFDE--EARVKDWDK---YGLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQS 382
Cdd:COG2335    56 VDTLSGEGPFTVFAPTDAAFAAlpAGTLDALLKpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGG 134

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767974779  383 TVYINNkAKIISSDIISTNGIVHIIDKLLSP 413
Cdd:COG2335   135 GVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
318-414 1.54e-22

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 93.20  E-value: 1.54e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779    318 TVFAPLSAAFDE-EARVKDWDKYgLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQ--STVYINNkAKIIS 394
Cdd:smart00554    1 TVFAPTDEAFQKlPPDLNSLLAD-KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVE 77

                            90       100
                    ....*....|....*....|
gi 767974779    395 SDIISTNGIVHIIDKLLSPK 414
Cdd:smart00554   78 ADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
465-571 1.93e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.64  E-value: 1.93e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779    465 TLFWPTDQALHALPAEQQDFLfnqdnKDKLKEYLKFHVIRDaKVLAVDLPTSTAWKTLQGSELSVKCgaGRDIGDLFLNG 544
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR--SGGSGTVTVNG 72

                            90       100
                    ....*....|....*....|....*..
gi 767974779    545 QtcRIVQRELLFDLGVAYGIDCLLIDP 571
Cdd:smart00554   73 A--RIVEADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 429-569 1.12e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.79  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  429 QNLTTLATNNGyiKFSNL---IQDSGLLSVITDPihTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIrD 505
Cdd:COG2335    31 KNIVETAANNP--DFSTLvaaLKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVV-P 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974779  506 AKVLAVDLPTSTAWKTLQGSELSVKcgagRDIGDLFLNGQTcrIVQRELLFDLGVAYGIDCLLI 569
Cdd:COG2335   106 GKVTAADLKDGKTLTTLQGQTLTVT----VSGGGVTVNGAN--VITADIEASNGVIHVIDKVLL 163
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1043-1136 1.84e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.17  E-value: 1.84e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   1043 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPlqptETRFVDGR 1112
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 767974779   1113 AILQWDIFASNGIIHVISRPLKAP 1136
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1043-1133 5.71e-08

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 52.64  E-value: 5.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  1043 TLFVPQNSGLGE------NETLSGRD-----IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLqptetrFVDG 1111
Cdd:pfam02469   27 TVFAPTNEAFAKlpagtlNFLLKDKEqlknlLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVTGGSV------TVNG 99

                           90       100
                   ....*....|....*....|..
gi 767974779  1112 RAILQWDIFASNGIIHVISRPL 1133
Cdd:pfam02469  100 ARVVQADIEATNGVIHVIDKVL 121
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 162-198 8.50e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.13  E-value: 8.50e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   162 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 198
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 814-851 3.22e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 3.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767974779   814 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 851
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 246-282 6.39e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 6.39e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   246 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 282
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 982-1133 2.67e-06

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 48.75  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  982 VNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNfLTEVLAYSNssargraflehLTD-LSIRG--TLFVPQNS-----GLG 1053
Cdd:COG2335    14 AACASSAAAEGAAMAPTKNIVETAANNPDFST-LVAALKAAG-----------LVDtLSGEGpfTVFAPTDAafaalPAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779 1054 ENETLSG-------RDI-EHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLQptetrfVDGRAILQWDIFASNGI 1125
Cdd:COG2335    82 TLDALLKpenkatlTKIlTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT------VNGANVITADIEASNGV 154


                  ....*...
gi 767974779 1126 IHVISRPL 1133
Cdd:COG2335   155 IHVIDKVL 162
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 204-240 1.64e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.97  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   204 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 240
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 773-808 3.75e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 3.75e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767974779   773 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 808
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 124-156 4.28e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 4.28e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974779   124 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 156
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 885-977 4.42e-52

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 177.27  E-value: 4.42e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  885 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 964
Cdd:cd03515     1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                          90
                  ....*....|...
gi 767974779  965 RPNKSEMWDVFCY 977
Cdd:cd03515    81 RLNLSERWDAYCY 93
Xlink pfam00193
Extracellular link domain;
885-977 3.78e-37

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 134.62  E-value: 3.78e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   885 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 964
Cdd:pfam00193    1 GVFHLESP-GRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 767974779   965 RPNKSEMWDVFCY 977
Cdd:pfam00193   80 RDPLSERYDAYCY 92
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 304-413 2.28e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 2.28e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   304 QEHFVKDLVGP-GPFTVFAPLSAAFDE--EARVKDW-DKYGLMPQVLRYHVVAChQLLLENLKLISNATSLQGEPIVISV 379
Cdd:pfam02469   12 AAGLVDTLNGSqGPFTVFAPTNEAFAKlpAGTLNFLlKDKEQLKNLLKYHVVPG-RLTSSDLKNGGTLATLQGSKLRVNV 90

                           90       100       110
                   ....*....|....*....|....*....|....
gi 767974779   380 SQSTVYINNkAKIISSDIISTNGIVHIIDKLLSP 413
Cdd:pfam02469   91 TGGSVTVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 439-569 2.30e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.11  E-value: 2.30e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   439 GYIKFSNLIQDSGLLSVITDPiHTPVTLFWPTDQALHALPAEQQDFLFNqdNKDKLKEYLKFHVIRDaKVLAVDLPTSTA 518
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNGS-QGPFTVFAPTNEAFAKLPAGTLNFLLK--DKEQLKNLLKYHVVPG-RLTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 767974779   519 WKTLQGSELSVKCGAGRdigdLFLNGqtCRIVQRELLFDLGVAYGIDCLLI 569
Cdd:pfam02469   78 LATLQGSKLRVNVTGGS----VTVNG--ARVVQADIEATNGVIHVIDKVLL 122
LINK smart00445
Link (Hyaluronan-binding);
885-978 1.26e-26

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 104.73  E-value: 1.26e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779    885 GVFHLRsPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGp 964
Cdd:smart00445    3 GVFHVE-KNGRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQYG- 80

                            90
                    ....*....|....
gi 767974779    965 RPNKSEMWDVFCYR 978
Cdd:smart00445   81 FPDPTSRYDAYCFN 94
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 308-413 4.96e-24

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 99.98  E-value: 4.96e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  308 VKDLVGPGPFTVFAPLSAAFDE--EARVKDWDK---YGLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQS 382
Cdd:COG2335    56 VDTLSGEGPFTVFAPTDAAFAAlpAGTLDALLKpenKATLTKILTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGG 134

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767974779  383 TVYINNkAKIISSDIISTNGIVHIIDKLLSP 413
Cdd:COG2335   135 GVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 885-977 1.04e-23

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 96.33  E-value: 1.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  885 GVFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGP 964
Cdd:cd01102     1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGRNPGVRSYGN 80

                          90
                  ....*....|...
gi 767974779  965 rPNKSEMWDVFCY 977
Cdd:cd01102    81 -PAPSGRYDAYCF 92
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
318-414 1.54e-22

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 93.20  E-value: 1.54e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779    318 TVFAPLSAAFDE-EARVKDWDKYgLMPQVLRYHVVAcHQLLLENLKLISNATSLQGEPIVISVSQ--STVYINNkAKIIS 394
Cdd:smart00554    1 TVFAPTDEAFQKlPPDLNSLLAD-KLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVE 77

                            90       100
                    ....*....|....*....|
gi 767974779    395 SDIISTNGIVHIIDKLLSPK 414
Cdd:smart00554   78 ADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
465-571 1.93e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.64  E-value: 1.93e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779    465 TLFWPTDQALHALPAEQQDFLfnqdnKDKLKEYLKFHVIRDaKVLAVDLPTSTAWKTLQGSELSVKCgaGRDIGDLFLNG 544
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITR--SGGSGTVTVNG 72

                            90       100
                    ....*....|....*....|....*..
gi 767974779    545 QtcRIVQRELLFDLGVAYGIDCLLIDP 571
Cdd:smart00554   73 A--RIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 886-977 2.91e-17

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 78.22  E-value: 2.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  886 VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNC---GSGVVGIVDY 962
Cdd:cd03517     2 VFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCygdMDGFPGVRNY 81

                          90
                  ....*....|....*
gi 767974779  963 GPRpNKSEMWDVFCY 977
Cdd:cd03517    82 GVR-DPDELYDVYCY 95
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 886-977 6.38e-17

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 77.08  E-value: 6.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  886 VFHLRSPLGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCG--SGVVGIVDYG 963
Cdd:cd03518     2 VFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGgkRTVPGLRSYG 81

                          90
                  ....*....|....
gi 767974779  964 PRPNKSEMWDVFCY 977
Cdd:cd03518    82 ERDKMLSRYDAFCF 95
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 429-569 1.12e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.79  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  429 QNLTTLATNNGyiKFSNL---IQDSGLLSVITDPihTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIrD 505
Cdd:COG2335    31 KNIVETAANNP--DFSTLvaaLKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGTLDALLKPENKATLTKILTYHVV-P 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974779  506 AKVLAVDLPTSTAWKTLQGSELSVKcgagRDIGDLFLNGQTcrIVQRELLFDLGVAYGIDCLLI 569
Cdd:COG2335   106 GKVTAADLKDGKTLTTLQGQTLTVT----VSGGGVTVNGAN--VITADIEASNGVIHVIDKVLL 163
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1043-1136 1.84e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.17  E-value: 1.84e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779   1043 TLFVPQNSGLgeNETLSGRD----------IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPlqptETRFVDGR 1112
Cdd:smart00554    1 TVFAPTDEAF--QKLPPDLNslladklknlLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGGS----GTVTVNGA 73

                            90       100
                    ....*....|....*....|....
gi 767974779   1113 AILQWDIFASNGIIHVISRPLKAP 1136
Cdd:smart00554   74 RIVEADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 886-977 2.21e-13

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 66.95  E-value: 2.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  886 VFHLRSPlgqYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVG---IVDY 962
Cdd:cd03520     2 VFYATAP---EKFTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGGLPGvrtLYRF 78

                          90
                  ....*....|....*...
gi 767974779  963 GPR---PNKSEMWDVFCY 977
Cdd:cd03520    79 PNQtgfPDPHSRFDAYCF 96
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 885-977 5.23e-12

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 62.83  E-value: 5.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  885 GVFHLRSPLgqyKLTFDKAREACANEAATMATYNQLSYAQK-AKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYG 963
Cdd:cd03519     1 GVFYLLHPG---KLTFSEAVAACQRDGAQIAKVGQLFAAWKfHGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFG 77

                          90
                  ....*....|....
gi 767974779  964 PRPNKSEMWDVFCY 977
Cdd:cd03519    78 FPDKKHKLYGVYCY 91
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 885-981 5.85e-10

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 59.01  E-value: 5.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  885 GVFHLRSPlGQYKLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYgp 964
Cdd:cd03516     7 GVFLVEKN-GRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCGKNGTGVYIL-- 83

                          90
                  ....*....|....*..
gi 767974779  965 RPNKSEMWDVFCYRMKD 981
Cdd:cd03516    84 NSNLSSRYDAYCYNSSD 100
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1043-1133 5.71e-08

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 52.64  E-value: 5.71e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  1043 TLFVPQNSGLGE------NETLSGRD-----IEHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLqptetrFVDG 1111
Cdd:pfam02469   27 TVFAPTNEAFAKlpagtlNFLLKDKEqlknlLKYHVVP-GRLTSSDLKNGGTLATLQGSKLRVNVTGGSV------TVNG 99

                           90       100
                   ....*....|....*....|..
gi 767974779  1112 RAILQWDIFASNGIIHVISRPL 1133
Cdd:pfam02469  100 ARVVQADIEATNGVIHVIDKVL 121
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 162-198 8.50e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.13  E-value: 8.50e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   162 CEISNGGCSAKADCKRTtPGRRVCTCKAGYTGDGIVC 198
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 814-851 3.22e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 47.59  E-value: 3.22e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767974779   814 CADGlNGGCHEHATCKMTgPGKHKCECKSHYVGDGLNC 851
Cdd:pfam12947    1 CSDN-NGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 246-282 6.39e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 6.39e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   246 CLTKNGGCSEFAICNHTGQvERTCTCKPNYIGDGFTC 282
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGG-SFTCTCNDGYTGDGVTC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 982-1133 2.67e-06

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 48.75  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779  982 VNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNfLTEVLAYSNssargraflehLTD-LSIRG--TLFVPQNS-----GLG 1053
Cdd:COG2335    14 AACASSAAAEGAAMAPTKNIVETAANNPDFST-LVAALKAAG-----------LVDtLSGEGpfTVFAPTDAafaalPAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974779 1054 ENETLSG-------RDI-EHHLANvSMFFYNDLVNGTTLQTRLGSKLLITASQDPLQptetrfVDGRAILQWDIFASNGI 1125
Cdd:COG2335    82 TLDALLKpenkatlTKIlTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVSGGGVT------VNGANVITADIEASNGV 154


                  ....*...
gi 767974779 1126 IHVISRPL 1133
Cdd:COG2335   155 IHVIDKVL 162
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 204-240 1.64e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.97  E-value: 1.64e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767974779   204 CLENHGGCDKNAECTQTgPNQAACNCLPAYTGDGKVC 240
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 773-808 3.75e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 3.75e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767974779   773 CKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSC 808
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 124-156 4.28e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 4.28e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767974779   124 NGTCHTSANClTNSDGTASCKCAAGFQGNGTIC 156
Cdd:pfam12947    5 NGGCHPNATC-TNTGGSFTCTCNDGYTGDGVTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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