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Conserved domains on  [gi|767974945|ref|XP_011536905|]
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calcium-binding and coiled-coil domain-containing protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
122-596 0e+00

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


:

Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 540.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  122 RPMDELVTLEEA----DGGSDILLVVPKATVLQNQLDESQQERNDLMQL------------------KLQLEGQVTELRS 179
Cdd:pfam07888   1 KPLDELVTLEEEshgeEGGTDMLLVVPRAELLQNRLEECLQERAELLQAqeaanrqrekekerykrdREQWERQRRELES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  180 RVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVK 259
Cdd:pfam07888  81 RVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  260 altreqeKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELE 339
Cdd:pfam07888 161 -------KAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  340 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV 419
Cdd:pfam07888 234 ALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSA 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  420 EAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 499
Cdd:pfam07888 314 EADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEY 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  500 MRKLEARLEKVADEKWNEDATTEDEEAavglscPAALTDSEDESPEDMRLPP----YGLCERG-----DPGSSPAGPREA 570
Cdd:pfam07888 394 IRQLEQRLETVADAKWSEAALTSTERP------DSPLSDSEDENPEALQPPRplghYSLCEQGqpdslLLATPPPSPRDP 467
                         490       500
                  ....*....|....*....|....*.
gi 767974945  571 SPLVVISQPAPISPHlsgpaEDSSSD 596
Cdd:pfam07888 468 ESTVVISQPAPLSSP-----HQSSSD 488
SKICH pfam17751
SKICH domain; The SKICH domains of SKIP and PIPP mediate plasma membrane localization. The ...
15-118 7.28e-40

SKICH domain; The SKICH domains of SKIP and PIPP mediate plasma membrane localization. The functions of the SKICH domains of NDP52 and CALCOCO1 are not known.


:

Pssm-ID: 465482  Cd Length: 102  Bit Score: 141.61  E-value: 7.28e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWssVPESTTDGSPIHTSVQFQASYLPKPG 94
Cdd:pfam17751   1 VVFQNVGEWYPPDEDIECSYTLTPDFTPSSWDWIGLFKVGWKSVNDYVTYVW--AKDDEVEGSNSVRQVLFKASYLPKEP 78
                          90       100
                  ....*....|....*....|....
gi 767974945   95 AQLYQFRYVNRQGQVCGQSPPFQF 118
Cdd:pfam17751  79 EGFYQFCYVSNLGSVVGISTPFQF 102
Zn-C2H2_CALCOCO1 cd21967
C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing ...
678-706 4.34e-14

C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins; CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). It is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. It is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. It functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. In association with CCAR1, CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. CALCOCO1 contains a C2H2-type zinc binding domain.


:

Pssm-ID: 412013  Cd Length: 29  Bit Score: 66.37  E-value: 4.34e-14
                         10        20
                 ....*....|....*....|....*....
gi 767974945 678 KECPICKERFPAESDKDALEDHMDGHFFF 706
Cdd:cd21967    1 KECPICKERFPLECDKDALEDHIDSHFFF 29
 
Name Accession Description Interval E-value
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
122-596 0e+00

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 540.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  122 RPMDELVTLEEA----DGGSDILLVVPKATVLQNQLDESQQERNDLMQL------------------KLQLEGQVTELRS 179
Cdd:pfam07888   1 KPLDELVTLEEEshgeEGGTDMLLVVPRAELLQNRLEECLQERAELLQAqeaanrqrekekerykrdREQWERQRRELES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  180 RVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVK 259
Cdd:pfam07888  81 RVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  260 altreqeKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELE 339
Cdd:pfam07888 161 -------KAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  340 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV 419
Cdd:pfam07888 234 ALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSA 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  420 EAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 499
Cdd:pfam07888 314 EADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEY 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  500 MRKLEARLEKVADEKWNEDATTEDEEAavglscPAALTDSEDESPEDMRLPP----YGLCERG-----DPGSSPAGPREA 570
Cdd:pfam07888 394 IRQLEQRLETVADAKWSEAALTSTERP------DSPLSDSEDENPEALQPPRplghYSLCEQGqpdslLLATPPPSPRDP 467
                         490       500
                  ....*....|....*....|....*.
gi 767974945  571 SPLVVISQPAPISPHlsgpaEDSSSD 596
Cdd:pfam07888 468 ESTVVISQPAPLSSP-----HQSSSD 488
SKICH pfam17751
SKICH domain; The SKICH domains of SKIP and PIPP mediate plasma membrane localization. The ...
15-118 7.28e-40

SKICH domain; The SKICH domains of SKIP and PIPP mediate plasma membrane localization. The functions of the SKICH domains of NDP52 and CALCOCO1 are not known.


Pssm-ID: 465482  Cd Length: 102  Bit Score: 141.61  E-value: 7.28e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWssVPESTTDGSPIHTSVQFQASYLPKPG 94
Cdd:pfam17751   1 VVFQNVGEWYPPDEDIECSYTLTPDFTPSSWDWIGLFKVGWKSVNDYVTYVW--AKDDEVEGSNSVRQVLFKASYLPKEP 78
                          90       100
                  ....*....|....*....|....
gi 767974945   95 AQLYQFRYVNRQGQVCGQSPPFQF 118
Cdd:pfam17751  79 EGFYQFCYVSNLGSVVGISTPFQF 102
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
174-542 5.81e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 104.63  E-value: 5.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 174 VTELRSRVQELERALATAR--QEHTELMEQYKGISRSHgeiteERDILSRQQGDHVARILELEDDIQTISEKVLTKEVEL 251
Cdd:COG1196  195 LGELERQLEPLERQAEKAEryRELKEELKELEAELLLL-----KLRELEAELEELEAELEELEAELEELEAELAELEAEL 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 252 DRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQA 331
Cdd:COG1196  270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 332 QQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKE 411
Cdd:COG1196  350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 412 RAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQvfktELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQE 491
Cdd:COG1196  430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA----ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEG 505
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767974945 492 EKQELLEYMRKLEARL--EKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDE 542
Cdd:COG1196  506 FLEGVKAALLLAGLRGlaGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEV 558
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
167-491 3.96e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 89.36  E-value: 3.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   167 KLQLEGQVTELRSRVQELERALATARQEHT-------ELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT 239
Cdd:TIGR02169  669 SRSEPAELQRLRERLEGLKRELSSLQSELRrienrldELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSS 748
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   240 ISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQA----------DKEQSEAELQVAQQENHHLNLDLKEAKSWQEE 309
Cdd:TIGR02169  749 LEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEArlshsripeiQAELSKLEEEVSRIEARLREIEQKLNRLTLEK 828
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   310 QSAQAQRlKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
Cdd:TIGR02169  829 EYLEKEI-QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE 907
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   390 VNGRLAELGLHLKEEKCQWSkERAGLLQSVEAEKDKILKLSAEILRLEKaVQEERTQNQVFKTELAREKDSSLVQLSESK 469
Cdd:TIGR02169  908 LEAQIEKKRKRLSELKAKLE-ALEEELSEIEDPKGEDEEIPEEELSLED-VQAELQRVEEEIRALEPVNMLAIQEYEEVL 985
                          330       340
                   ....*....|....*....|..
gi 767974945   470 RELTELRSALRVLQKEKEQLQE 491
Cdd:TIGR02169  986 KRLDELKEKRAKLEEERKAILE 1007
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
149-527 1.95e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 77.39  E-value: 1.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITE---ERDILSRQQGD 225
Cdd:PRK02224 204 LHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRETIAEterEREELAEEVRD 283
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 226 HVARILELEDDIQTISEkvltkEVELDRLRDtvKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKS 305
Cdd:PRK02224 284 LRERLEELEEERDDLLA-----EAGLDDADA--EAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEE 356
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 306 WQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAaaaRDRTIAELHRSRL 385
Cdd:PRK02224 357 RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREE---RDELREREAELEA 433
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 386 EVAEVNGRLAELGLHLKEEKC---QWSKERAGLLQSVEAEKDKILKLSAEILRLEkaVQEERTQNQVFKTELAREKDSSL 462
Cdd:PRK02224 434 TLRTARERVEEAEALLEAGKCpecGQPVEGSPHVETIEEDRERVEELEAELEDLE--EEVEEVEERLERAEDLVEAEDRI 511
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767974945 463 VQLSESKRELTELRSalrvlqkEKEQLQEEKQELLEYMRKLEARLEKVADEKwnEDATTEDEEAA 527
Cdd:PRK02224 512 ERLEERREDLEELIA-------ERRETIEEKRERAEELRERAAELEAEAEEK--REAAAEAEEEA 567
Zn-C2H2_CALCOCO1 cd21967
C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing ...
678-706 4.34e-14

C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins; CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). It is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. It is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. It functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. In association with CCAR1, CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. CALCOCO1 contains a C2H2-type zinc binding domain.


Pssm-ID: 412013  Cd Length: 29  Bit Score: 66.37  E-value: 4.34e-14
                         10        20
                 ....*....|....*....|....*....
gi 767974945 678 KECPICKERFPAESDKDALEDHMDGHFFF 706
Cdd:cd21967    1 KECPICKERFPLECDKDALEDHIDSHFFF 29
Zn-C2H2_12 pfam18112
Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and ...
678-704 2.06e-10

Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and coiled-coil domain 2/NDP25 (CALCOCO2/NDP25) found in Homo sapiens. CALCOCO2/NDP25 is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. This domain is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.


Pssm-ID: 407946  Cd Length: 27  Bit Score: 55.73  E-value: 2.06e-10
                          10        20
                  ....*....|....*....|....*..
gi 767974945  678 KECPICKERFPAESDKDALEDHMDGHF 704
Cdd:pfam18112   1 KECPLCGEMFSPNIDQSEFEEHVESHF 27
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
230-347 3.43e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.47  E-value: 3.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   230 ILELEDDIQTISEKVLTKEVEL-----DRLRDTVKALTREqeklLGQLKEVQADKEQ-SEAELQVAQQENHHLNLDLKEA 303
Cdd:smart00787 148 GLDENLEGLKEDYKLLMKELELlnsikPKLRDRKDALEEE----LRQLKQLEDELEDcDPTELDRAKEKLKKLLQEIMIK 223
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 767974945   304 KSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRG 347
Cdd:smart00787 224 VKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
 
Name Accession Description Interval E-value
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
122-596 0e+00

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 540.64  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  122 RPMDELVTLEEA----DGGSDILLVVPKATVLQNQLDESQQERNDLMQL------------------KLQLEGQVTELRS 179
Cdd:pfam07888   1 KPLDELVTLEEEshgeEGGTDMLLVVPRAELLQNRLEECLQERAELLQAqeaanrqrekekerykrdREQWERQRRELES 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  180 RVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVK 259
Cdd:pfam07888  81 RVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  260 altreqeKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELE 339
Cdd:pfam07888 161 -------KAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENE 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  340 PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV 419
Cdd:pfam07888 234 ALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRARWAQERETLQQSA 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  420 EAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEY 499
Cdd:pfam07888 314 EADKDRIEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEY 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  500 MRKLEARLEKVADEKWNEDATTEDEEAavglscPAALTDSEDESPEDMRLPP----YGLCERG-----DPGSSPAGPREA 570
Cdd:pfam07888 394 IRQLEQRLETVADAKWSEAALTSTERP------DSPLSDSEDENPEALQPPRplghYSLCEQGqpdslLLATPPPSPRDP 467
                         490       500
                  ....*....|....*....|....*.
gi 767974945  571 SPLVVISQPAPISPHlsgpaEDSSSD 596
Cdd:pfam07888 468 ESTVVISQPAPLSSP-----HQSSSD 488
SKICH pfam17751
SKICH domain; The SKICH domains of SKIP and PIPP mediate plasma membrane localization. The ...
15-118 7.28e-40

SKICH domain; The SKICH domains of SKIP and PIPP mediate plasma membrane localization. The functions of the SKICH domains of NDP52 and CALCOCO1 are not known.


Pssm-ID: 465482  Cd Length: 102  Bit Score: 141.61  E-value: 7.28e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   15 VNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWssVPESTTDGSPIHTSVQFQASYLPKPG 94
Cdd:pfam17751   1 VVFQNVGEWYPPDEDIECSYTLTPDFTPSSWDWIGLFKVGWKSVNDYVTYVW--AKDDEVEGSNSVRQVLFKASYLPKEP 78
                          90       100
                  ....*....|....*....|....
gi 767974945   95 AQLYQFRYVNRQGQVCGQSPPFQF 118
Cdd:pfam17751  79 EGFYQFCYVSNLGSVVGISTPFQF 102
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
174-542 5.81e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 104.63  E-value: 5.81e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 174 VTELRSRVQELERALATAR--QEHTELMEQYKGISRSHgeiteERDILSRQQGDHVARILELEDDIQTISEKVLTKEVEL 251
Cdd:COG1196  195 LGELERQLEPLERQAEKAEryRELKEELKELEAELLLL-----KLRELEAELEELEAELEELEAELEELEAELAELEAEL 269
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 252 DRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQA 331
Cdd:COG1196  270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 332 QQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKE 411
Cdd:COG1196  350 EEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEA 429
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 412 RAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQvfktELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQE 491
Cdd:COG1196  430 LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA----ELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEG 505
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767974945 492 EKQELLEYMRKLEARL--EKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDE 542
Cdd:COG1196  506 FLEGVKAALLLAGLRGlaGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEV 558
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
145-529 3.20e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 89.61  E-value: 3.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQG 224
Cdd:COG1196  226 EAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIA 305
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 225 DHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAK 304
Cdd:COG1196  306 RLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 305 SWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSR 384
Cdd:COG1196  386 EELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELL 465
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 385 LEVAEVNGRLAELGLHLKEEKCQ-----WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKD 459
Cdd:COG1196  466 AELLEEAALLEAALAELLEELAEaaarlLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALA 545
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945 460 SSLVQ-LSESKRELTELRSALRV--------LQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVG 529
Cdd:COG1196  546 AALQNiVVEDDEVAAAAIEYLKAakagratfLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLG 624
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
167-491 3.96e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 89.36  E-value: 3.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   167 KLQLEGQVTELRSRVQELERALATARQEHT-------ELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQT 239
Cdd:TIGR02169  669 SRSEPAELQRLRERLEGLKRELSSLQSELRrienrldELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSS 748
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   240 ISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQA----------DKEQSEAELQVAQQENHHLNLDLKEAKSWQEE 309
Cdd:TIGR02169  749 LEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEArlshsripeiQAELSKLEEEVSRIEARLREIEQKLNRLTLEK 828
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   310 QSAQAQRlKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
Cdd:TIGR02169  829 EYLEKEI-QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE 907
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   390 VNGRLAELGLHLKEEKCQWSkERAGLLQSVEAEKDKILKLSAEILRLEKaVQEERTQNQVFKTELAREKDSSLVQLSESK 469
Cdd:TIGR02169  908 LEAQIEKKRKRLSELKAKLE-ALEEELSEIEDPKGEDEEIPEEELSLED-VQAELQRVEEEIRALEPVNMLAIQEYEEVL 985
                          330       340
                   ....*....|....*....|..
gi 767974945   470 RELTELRSALRVLQKEKEQLQE 491
Cdd:TIGR02169  986 KRLDELKEKRAKLEEERKAILE 1007
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
149-485 1.46e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 80.88  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKlqlegqvtELRSRVQELERALATARQEHTElmEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:TIGR02169  196 KRQQLERLRREREKAERYQ--------ALLKEKREYEGYELLKEKEALE--RQKEAIERQLASLEEELEKLTEEISELEK 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   229 RILELEDDIQTISEKVLTK-EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
Cdd:TIGR02169  266 RLEEIEQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREI 345
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   308 EEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEplkEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEV 387
Cdd:TIGR02169  346 EEERKRRDKLTEEYAELKEELEDLRAELEEVD---KEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEEL 422
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   388 AEVNGRLAELglhlkeekcqwskeRAGLLQSVEAEKDKILKLSA---EILRLEKAVQEERTQNQVFKTELAREKDsslvQ 464
Cdd:TIGR02169  423 ADLNAAIAGI--------------EAKINELEEEKEDKALEIKKqewKLEQLAADLSKYEQELYDLKEEYDRVEK----E 484
                          330       340
                   ....*....|....*....|.
gi 767974945   465 LSESKRELTELRSALRVLQKE 485
Cdd:TIGR02169  485 LSKLQRELAEAEAQARASEER 505
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
160-455 4.04e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 79.72  E-value: 4.04e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   160 RNDLMQLKLQLEG-QVTELRSRVQELERALATARQEHTELMEQykgISRSHGEITEERDI---LSRQQGDHVARILELED 235
Cdd:TIGR02168  219 KAELRELELALLVlRLEELREELEELQEELKEAEEELEELTAE---LQELEEKLEELRLEvseLEEEIEELQKELYALAN 295
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   236 DIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQE-------NHHLNLDLKEAKSWQE 308
Cdd:TIGR02168  296 EISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEElesleaeLEELEAELEELESRLE 375
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   309 EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQElaassQQKATLLGEELASAAAARDRTIAELHRSRLEVA 388
Cdd:TIGR02168  376 ELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE-----RLQQEIEELLKKLEEAELKELQAELEELEEELE 450
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767974945   389 EVNGRLAELGLHLKEEKcqwsKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELA 455
Cdd:TIGR02168  451 ELQEELERLEEALEELR----EELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLK 513
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
150-506 6.42e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 78.95  E-value: 6.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATAR-------QEHTELMEQYKGISRSHGEITEERDILSRQ 222
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRkeleelsRQISALRKDLARLEAEVEQLEERIAQLSKE 755
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   223 QGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKE 302
Cdd:TIGR02168  756 LTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAA 835
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   303 AKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEplkEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHR 382
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSE 912
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   383 SRLEVAEVNGRLAELGLHlkeekcqwskeraglLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSL 462
Cdd:TIGR02168  913 LRRELEELREKLAQLELR---------------LEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRL 977
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767974945   463 ---------VQLsESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
Cdd:TIGR02168  978 enkikelgpVNL-AAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDRE 1029
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
149-527 1.95e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 77.39  E-value: 1.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITE---ERDILSRQQGD 225
Cdd:PRK02224 204 LHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRETIAEterEREELAEEVRD 283
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 226 HVARILELEDDIQTISEkvltkEVELDRLRDtvKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKS 305
Cdd:PRK02224 284 LRERLEELEEERDDLLA-----EAGLDDADA--EAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEE 356
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 306 WQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAaaaRDRTIAELHRSRL 385
Cdd:PRK02224 357 RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREE---RDELREREAELEA 433
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 386 EVAEVNGRLAELGLHLKEEKC---QWSKERAGLLQSVEAEKDKILKLSAEILRLEkaVQEERTQNQVFKTELAREKDSSL 462
Cdd:PRK02224 434 TLRTARERVEEAEALLEAGKCpecGQPVEGSPHVETIEEDRERVEELEAELEDLE--EEVEEVEERLERAEDLVEAEDRI 511
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767974945 463 VQLSESKRELTELRSalrvlqkEKEQLQEEKQELLEYMRKLEARLEKVADEKwnEDATTEDEEAA 527
Cdd:PRK02224 512 ERLEERREDLEELIA-------ERRETIEEKRERAEELRERAAELEAEAEEK--REAAAEAEEEA 567
Zn-C2H2_CALCOCO1 cd21967
C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing ...
678-706 4.34e-14

C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins; CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). It is recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation CALCOCO1 acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. It is involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. It functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. In association with CCAR1, CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. CALCOCO1 contains a C2H2-type zinc binding domain.


Pssm-ID: 412013  Cd Length: 29  Bit Score: 66.37  E-value: 4.34e-14
                         10        20
                 ....*....|....*....|....*....
gi 767974945 678 KECPICKERFPAESDKDALEDHMDGHFFF 706
Cdd:cd21967    1 KECPICKERFPLECDKDALEDHIDSHFFF 29
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
149-526 5.51e-14

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 75.57  E-value: 5.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEgqvtELRSRVQELERALATARQEHTEL--MEQYKGISRSHGEITEERDILSRQQG-- 224
Cdd:COG4717   76 LEEELKEAEEKEEEYAELQEELE----ELEEELEELEAELEELREELEKLekLLQLLPLYQELEALEAELAELPERLEel 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 225 -DHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQ-EKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKe 302
Cdd:COG4717  152 eERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAELEEELEEAQEELEELEEELE- 230
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 303 akswQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLG-------EELASAAAARDR 375
Cdd:COG4717  231 ----QLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLAllflllaREKASLGKEAEE 306
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 376 TIAELHRSRLEVAEVNGRLAELGL-----------------HLKEEKCQWSKERAGL-LQSVEAEKDKILKLS------- 430
Cdd:COG4717  307 LQALPALEELEEEELEELLAALGLppdlspeellelldrieELQELLREAEELEEELqLEELEQEIAALLAEAgvedeee 386
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 431 -AEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKREltELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 509
Cdd:COG4717  387 lRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREELAELEAELEQ 464
                        410
                 ....*....|....*..
gi 767974945 510 VADEKWNEDATTEDEEA 526
Cdd:COG4717  465 LEEDGELAELLQELEEL 481
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
149-504 1.76e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 74.33  E-value: 1.76e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRshgEITEERDilsrQQGDHVA 228
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQ---EIENVKS----ELKELEA 765
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   229 RILELEDDIQTISEKVLTKEVELDRLR-DTVKALTREQEK----LLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEA 303
Cdd:TIGR02169  766 RIEELEEDLHKLEEALNDLEARLSHSRiPEIQAELSKLEEevsrIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL 845
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   304 KSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGaQELAASSQQKATLLGEELASAAAARDRTIAELHRS 383
Cdd:TIGR02169  846 KEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKK-ERDELEAQLRELERKIEELEAQIEKKRKRLSELKA 924
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   384 RLEVAEvnGRLAELGLHLKEEkcqwsKERAGLLQSVEAEKDKILKLSAEILRLE----KAVQEertqnqvFKTELAREKD 459
Cdd:TIGR02169  925 KLEALE--EELSEIEDPKGED-----EEIPEEELSLEDVQAELQRVEEEIRALEpvnmLAIQE-------YEEVLKRLDE 990
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 767974945   460 sslvqlseskreltelrsalrvLQKEKEQLQEEKQELLEYMRKLE 504
Cdd:TIGR02169  991 ----------------------LKEKRAKLEEERKAILERIEEYE 1013
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
244-542 2.73e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 73.55  E-value: 2.73e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   244 VLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQ 323
Cdd:TIGR02168  672 ILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQ 751
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   324 MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRsrlEVAEVNGRLAELGLHLKE 403
Cdd:TIGR02168  752 LSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRA---ELTLLNEEAANLRERLES 828
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   404 EKCQ---WSKERAGLLQSVEAEKDKILKLSAEILRLEKAV---QEERTQNQVFKTELAREKDSSLVQLSESKRELTELRS 477
Cdd:TIGR02168  829 LERRiaaTERRLEDLEEQIEELSEDIESLAAEIEELEELIeelESELEALLNERASLEEALALLRSELEELSEELRELES 908
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767974945   478 ALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDE 542
Cdd:TIGR02168  909 KRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRR 973
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
276-513 3.78e-13

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 71.72  E-value: 3.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 276 QADKEQSEAELQVAQQEnhhlnldLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEplkeqlrgaQELAASS 355
Cdd:COG4942   19 ADAAAEAEAELEQLQQE-------IAELEKELAALKKEEKALLKQLAALERRIAALARRIRALE---------QELAALE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 356 QQKATLlGEELASAAAARDRTIAELhRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSV-EAEKDKILKLSA--- 431
Cdd:COG4942   83 AELAEL-EKEIAELRAELEAQKEEL-AELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLaPARREQAEELRAdla 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 432 EILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVA 511
Cdd:COG4942  161 ELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240

                 ..
gi 767974945 512 DE 513
Cdd:COG4942  241 ER 242
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
149-398 8.36e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 72.01  E-value: 8.36e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATER 838
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKswqe 308
Cdd:TIGR02168  839 RLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELR---- 914
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   309 eqsAQAQRLKDKVAQMKDTLGQAQQRVAElepLKEQLRGAQELAAssqqkatllgEELASAAAARDRTIAELHRsrlEVA 388
Cdd:TIGR02168  915 ---RELEELREKLAQLELRLEGLEVRIDN---LQERLSEEYSLTL----------EEAEALENKIEDDEEEARR---RLK 975
                          250
                   ....*....|
gi 767974945   389 EVNGRLAELG 398
Cdd:TIGR02168  976 RLENKIKELG 985
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
149-527 9.89e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 71.89  E-value: 9.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:COG1196  335 LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLE 414
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKS--- 305
Cdd:COG1196  415 RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAArll 494
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 306 ------WQEEQSAQAQRLKDKVAQMKD----------------------TLGQAQQRVAE--------LEPLKEQLRGAQ 349
Cdd:COG1196  495 llleaeADYEGFLEGVKAALLLAGLRGlagavavligveaayeaaleaaLAAALQNIVVEddevaaaaIEYLKAAKAGRA 574
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 350 ELAASSQQKATLLGEELASAAAARDRTI-----AELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKD 424
Cdd:COG1196  575 TFLPLDKIRARAALAAALARGAIGAAVDlvasdLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGE 654
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 425 KILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRV---------LQKEKEQLQEEKQE 495
Cdd:COG1196  655 GGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEaeeerleeeLEEEALEEQLEAER 734
                        410       420       430
                 ....*....|....*....|....*....|..
gi 767974945 496 LLEYMRKLEARLEKVADEKwNEDATTEDEEAA 527
Cdd:COG1196  735 EELLEELLEEEELLEEEAL-EELPEPPDLEEL 765
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
149-513 3.05e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 70.48  E-value: 3.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:TIGR02169  341 LEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSE 420
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSwQE 308
Cdd:TIGR02169  421 ELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEA-QA 499
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   309 EQSAQAQR-LKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAA---ARDR-----TIAE 379
Cdd:TIGR02169  500 RASEERVRgGRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAVAKEAielLKRRkagraTFLP 579
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   380 LHRSRLEVAEVnGRLAELG-----LHLKEEKCQWSK------ERAGLLQSVEAEKD-----KILKLSAEIL--------- 434
Cdd:TIGR02169  580 LNKMRDERRDL-SILSEDGvigfaVDLVEFDPKYEPafkyvfGDTLVVEDIEAARRlmgkyRMVTLEGELFeksgamtgg 658
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   435 -------RLEKAVQEERTQN-QVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
Cdd:TIGR02169  659 sraprggILFSRSEPAELQRlRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER 738

                   ....*..
gi 767974945   507 LEKVADE 513
Cdd:TIGR02169  739 LEELEED 745
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
150-513 4.18e-12

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 69.66  E-value: 4.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQEL--ERALATARQEHTELMEQYKGISRSHGEITEERDILSR--QQgd 225
Cdd:TIGR04523 266 KKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLnnQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQlnEQ-- 343
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  226 hvarILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKS 305
Cdd:TIGR04523 344 ----ISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ 419
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  306 WQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQElaaSSQQKATLLGEELASAAAARDRTIAELHRSRL 385
Cdd:TIGR04523 420 EKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRE---SLETQLKVLSRSINKIKQNLEQKQKELKSKEK 496
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  386 EVAEvngrlaelglhLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAR-----EKDS 460
Cdd:TIGR04523 497 ELKK-----------LNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKenlekEIDE 565
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767974945  461 SLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 513
Cdd:TIGR04523 566 KNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKE 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
149-509 8.28e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.81  E-value: 8.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:COG1196  370 AEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLK------- 301
Cdd:COG1196  450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLagavavl 529
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 302 ---EAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQ--------RVAELEPLKEQLRGAQELAASS--QQKATLLGEELAS 368
Cdd:COG1196  530 igvEAAYEAALEAALAAALQNIVVEDDEVAAAAIEylkaakagRATFLPLDKIRARAALAAALARgaIGAAVDLVASDLR 609
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 369 AAAARDRTIAELHRSRLEVAE----VNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
Cdd:COG1196  610 EADARYYVLGDTLLGRTLVAArleaALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLA 689
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 445 TQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMR-----------------KLEARL 507
Cdd:COG1196  690 EEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEElleeealeelpeppdleELEREL 769

                 ..
gi 767974945 508 EK 509
Cdd:COG1196  770 ER 771
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
169-514 3.38e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.60  E-value: 3.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 169 QLEGQVTELRSRVQELERALATAR--------------QEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELE 234
Cdd:PRK02224 353 DLEERAEELREEAAELESELEEAReavedrreeieeleEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELE 432
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 235 DDIQTISEKVltkeVELDRLRDTVKALTREQEKLLGQLKEVQADKEQ---------SEAELQVAQQENHHLNL-DLKEAK 304
Cdd:PRK02224 433 ATLRTARERV----EEAEALLEAGKCPECGQPVEGSPHVETIEEDRErveeleaelEDLEEEVEEVEERLERAeDLVEAE 508
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 305 SWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAElepLKEQlrgAQELAASSQQKAtllgeelASAAAARDRtiAELHRSr 384
Cdd:PRK02224 509 DRIERLEERREDLEELIAERRETIEEKRERAEE---LRER---AAELEAEAEEKR-------EAAAEAEEE--AEEARE- 572
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 385 lEVAEVNGRLAELglhlkeekcqwsKERAGLLQSVEAEKDKILKLSAEILRLekavQEERTQnqvfKTELAREKDSSLVQ 464
Cdd:PRK02224 573 -EVAELNSKLAEL------------KERIESLERIRTLLAAIADAEDEIERL----REKREA----LAELNDERRERLAE 631
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 767974945 465 LSESKRELTELRSALRVlqkekEQLQEEKQELLEYMRKLEARLEKVADEK 514
Cdd:PRK02224 632 KRERKRELEAEFDEARI-----EEAREDKERAEEYLEQVEEKLDELREER 676
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
145-375 4.68e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 65.17  E-value: 4.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQG 224
Cdd:COG4942   21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELE 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 225 DHVARILELEDDIQTISEKVLTKEV-------ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQEnhhLN 297
Cdd:COG4942  101 AQKEELAELLRALYRLGRQPPLALLlspedflDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE---LE 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767974945 298 LDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLrgaQELAASSQQKATLLGEELASAAAARDR 375
Cdd:COG4942  178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL---EALIARLEAEAAAAAERTPAAGFAALK 252
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
170-497 6.30e-11

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 65.61  E-value: 6.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  170 LEGQVTELRSRVQELERALATARQEHTELMEQYKGISrshGEITEERDILSRQQgdhvARILELEDDIQTISEKVLTKEV 249
Cdd:pfam10174 343 LQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLA---GEIRDLKDMLDVKE----RKINVLQKKIENLQEQLRDKDK 415
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  250 ELDRLRDTVK-----------ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAK-------------- 304
Cdd:pfam10174 416 QLAGLKERVKslqtdssntdtALTTLEEALSEKERIIERLKEQREREDRERLEELESLKKENKDLKekvsalqpelteke 495
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  305 ----SWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQ-------------QKATLLGEELA 367
Cdd:pfam10174 496 ssliDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRtnpeindrirlleQEVARYKEESG 575
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  368 SAAAARDRTIAELHRSRLEVAEVNGRLAEL--------------GLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEI 433
Cdd:pfam10174 576 KAQAEVERLLGILREVENEKNDKDKKIAELesltlrqmkeqnkkVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQL 655
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767974945  434 LRLEKAVQEERTQNQVFKTELareKDSSLVQ-LSESKRELTELRSALRvlqKEKEQLQEEKQELL 497
Cdd:pfam10174 656 QLEELMGALEKTRQELDATKA---RLSSTQQsLAEKDGHLTNLRAERR---KQLEEILEMKQEAL 714
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
149-518 1.08e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 65.14  E-value: 1.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQ-----LEGQVTELRSRVQELERALATARQEHTELMEQYKGISRshgEITEERDILSRQQ 223
Cdd:pfam15921  243 VEDQLEALKSESQNKIELLLQqhqdrIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQE---QARNQNSMYMRQL 319
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   224 GDHVARILEL-----------EDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQE 292
Cdd:pfam15921  320 SDLESTVSQLrselreakrmyEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQ 399
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   293 NHHL-------NLDLKEAKSWQEEQSAQAQRLKDKVAQMK-DTLGQAQQRV-----------------AELEPLKEQLRG 347
Cdd:pfam15921  400 NKRLwdrdtgnSITIDHLRRELDDRNMEVQRLEALLKAMKsECQGQMERQMaaiqgkneslekvssltAQLESTKEMLRK 479
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   348 -AQELAA------SSQQKATLLGEELASAAAARDRTIAELHRSRlevAEVNGRLAELGlHLK--EEKCQWSKERAGLLQS 418
Cdd:pfam15921  480 vVEELTAkkmtleSSERTVSDLTASLQEKERAIEATNAEITKLR---SRVDLKLQELQ-HLKneGDHLRNVQTECEALKL 555
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   419 VEAEKDKILK-LSAEILRLEKAV-QEERTQN--QVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQ 494
Cdd:pfam15921  556 QMAEKDKVIEiLRQQIENMTQLVgQHGRTAGamQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKV 635
                          410       420
                   ....*....|....*....|....
gi 767974945   495 ELLEYMRKleaRLEKVADEKWNED 518
Cdd:pfam15921  636 KLVNAGSE---RLRAVKDIKQERD 656
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
149-526 1.70e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 64.27  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTEL---MEQYKGISRSHGEITEERDILSRQQGd 225
Cdd:TIGR04523 150 KEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLellLSNLKKKIQKNKSLESQISELKKQNN- 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  226 hvarilELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQ-----SEAELQVAQQENHHLNLDL 300
Cdd:TIGR04523 229 ------QLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQnnkkiKELEKQLNQLKSEISDLNN 302
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  301 KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRgaQELAASSQQKATlLGEELASAAAARDRTIAEL 380
Cdd:TIGR04523 303 QKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLK--KELTNSESENSE-KQRELEEKQNEIEKLKKEN 379
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  381 HRSRLEVAEVNGRLAELGLHLKEEKcQWSKERAGLLQSVEAEKDKILK----LSAEILRLEKAVQEERTQNQVFKT---E 453
Cdd:TIGR04523 380 QSYKQEIKNLESQINDLESKIQNQE-KLNQQKDEQIKKLQQEKELLEKeierLKETIIKNNSEIKDLTNQDSVKELiikN 458
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767974945  454 LAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEarlEKVADEKWNEDATTEDEEA 526
Cdd:TIGR04523 459 LDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELE---EKVKDLTKKISSLKEKIEK 528
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
232-490 1.86e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 64.55  E-value: 1.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  232 ELEDDIQTISEkvltkevELDRLRDTVKAL--TREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLdlkeaksWQEE 309
Cdd:COG4913   222 DTFEAADALVE-------HFDDLERAHEALedAREQIELLEPIRELAERYAAARERLAELEYLRAALRL-------WFAQ 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  310 QsaQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRgaQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAE 389
Cdd:COG4913   288 R--RLELLEAELEELRAELARLEAELERLEARLDALR--EELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRAR 363
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  390 VNGRLAELGLHLKEEkcqwskeragllqsveaekdkilklsaeilrlEKAVQEERTQNQVFKTELAREKDSSLVQLSESK 469
Cdd:COG4913   364 LEALLAALGLPLPAS--------------------------------AEEFAALRAEAAALLEALEEELEALEEALAEAE 411
                         250       260
                  ....*....|....*....|.
gi 767974945  470 RELTELRSALRVLQKEKEQLQ 490
Cdd:COG4913   412 AALRDLRRELRELEAEIASLE 432
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
152-503 1.88e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 64.31  E-value: 1.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 152 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQ-------------YKGISRSHGEITEERDI 218
Cdd:PRK03918 232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKvkelkelkekaeeYIKLSEFYEEYLDELRE 311
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTR--EQEKLLGQLKEVQADKEQSEAELqvAQQENHHL 296
Cdd:PRK03918 312 IEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEleERHELYEEAKAKKEELERLKKRL--TGLTPEKL 389
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 297 NLDLKEAKSWQEEQSAQAQRLKDKVAQMKdtlgqaqQRVAELEPLKEQLRGAqelaassQQKATLLGEELASAAAAR--D 374
Cdd:PRK03918 390 EKELEELEKAKEEIEEEISKITARIGELK-------KEIKELKKAIEELKKA-------KGKCPVCGRELTEEHRKEllE 455
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVfkTEL 454
Cdd:PRK03918 456 EYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKL--KEK 533
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 767974945 455 AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKL 503
Cdd:PRK03918 534 LIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEEL 582
Zn-C2H2_12 pfam18112
Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and ...
678-704 2.06e-10

Autophagy receptor zinc finger-C2H2 domain; This domain is found in calcium-binding and coiled-coil domain 2/NDP25 (CALCOCO2/NDP25) found in Homo sapiens. CALCOCO2/NDP25 is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. This domain is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.


Pssm-ID: 407946  Cd Length: 27  Bit Score: 55.73  E-value: 2.06e-10
                          10        20
                  ....*....|....*....|....*..
gi 767974945  678 KECPICKERFPAESDKDALEDHMDGHF 704
Cdd:pfam18112   1 KECPLCGEMFSPNIDQSEFEEHVESHF 27
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
162-513 2.64e-10

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 63.93  E-value: 2.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 162 DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITE-ERDILSRQQgdhvaRILELEDDIQTI 240
Cdd:PRK03918 190 NIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEElEKELESLEG-----SKRKLEEKIREL 264
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 241 SEKVLTKEVELDRLRDTVKALT------REQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAkswqEEQSAQA 314
Cdd:PRK03918 265 EERIEELKKEIEELEEKVKELKelkekaEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEL----EEKEERL 340
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 315 QRLKDKVAQMKDTLGQAQQRVAELE---PLKEQLRG-AQELAASSQQKatlLGEELASAAAARDRTIAELHRSRLEVAEV 390
Cdd:PRK03918 341 EELKKKLKELEKRLEELEERHELYEeakAKKEELERlKKRLTGLTPEK---LEKELEELEKAKEEIEEEISKITARIGEL 417
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 391 NGRLAELGLHLKEEKCQWSK-----------ERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTqnqvfKTELAREKD 459
Cdd:PRK03918 418 KKEIKELKKAIEELKKAKGKcpvcgrelteeHRKELLEEYTAELKRIEKELKEIEEKERKLRKELR-----ELEKVLKKE 492
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767974945 460 SSLVQLSESKRELTELRSALRVLQKEK-EQLQEEKQELLEYMRKLEARLEKVADE 513
Cdd:PRK03918 493 SELIKLKELAEQLKELEEKLKKYNLEElEKKAEEYEKLKEKLIKLKGEIKSLKKE 547
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
158-546 5.02e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.14  E-value: 5.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 158 QERNDLMQLKLQLEGQV-TELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEerdILSRQQGDHvARILELEDD 236
Cdd:PRK02224 184 DQRGSLDQLKAQIEEKEeKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADE---VLEEHEERR-EELETLEAE 259
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 237 IQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQR 316
Cdd:PRK02224 260 IEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQA 339
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 317 LKDkvaqmkdtlgqaqqrvaELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAE 396
Cdd:PRK02224 340 HNE-----------------EAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGD 402
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 397 LGLHLKEEkcqwSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT-ELARE-KDSSLVQLSESKRE-LT 473
Cdd:PRK02224 403 APVDLGNA----EDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCpECGQPvEGSPHVETIEEDRErVE 478
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 474 ELRSALRVLQKEKEQLqEEKQELLEYMRKLEARLEKVADEKWN--------EDATTEDEEAAVGLSCPAALTDSEDESPE 545
Cdd:PRK02224 479 ELEAELEDLEEEVEEV-EERLERAEDLVEAEDRIERLEERREDleeliaerRETIEEKRERAEELRERAAELEAEAEEKR 557

                 .
gi 767974945 546 D 546
Cdd:PRK02224 558 E 558
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
158-524 5.66e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 62.75  E-value: 5.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 158 QERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDI 237
Cdd:PRK02224 314 ARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEI 393
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 238 QTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQenhhlnldLKEAKSWQEeqsaQAQRL 317
Cdd:PRK02224 394 EELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEA--------LLEAGKCPE----CGQPV 461
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 318 KDkvAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAtllgEELASAAAARDRTIAELHRSRLEVAEVNGRLAEl 397
Cdd:PRK02224 462 EG--SPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERA----EDLVEAEDRIERLEERREDLEELIAERRETIEE- 534
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 398 glhlKEEKCQWSKERAGLLQSVEAEKDkilklsAEILRLEKAVQEERTQNQVFKTELAREKDS--SLVQLSESKRELTEL 475
Cdd:PRK02224 535 ----KRERAEELRERAAELEAEAEEKR------EAAAEAEEEAEEAREEVAELNSKLAELKERieSLERIRTLLAAIADA 604
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767974945 476 RSALRVLQKEKEQLQEEKQELLEYM-------RKLEARLEKVADEKWNEDATTEDE 524
Cdd:PRK02224 605 EDEIERLREKREALAELNDERRERLaekrerkRELEAEFDEARIEEAREDKERAEE 660
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
228-456 6.22e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.70  E-value: 6.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 228 ARILELEDDIQTISEkvltkevELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
Cdd:COG4942   20 DAAAEAEAELEQLQQ-------EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 308 EEQSAQAQRLKDKVAQMKDTLgQAQQRVAELEPLkeqlrgaqeLAASSQQKATLLGEELASAAAARDRTIAELHRSRLEV 387
Cdd:COG4942   93 AELRAELEAQKEELAELLRAL-YRLGRQPPLALL---------LSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAEL 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945 388 AEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAR 456
Cdd:COG4942  163 AALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
151-509 1.55e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 61.23  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 151 NQLDESQQERNDLMQLKLQLEGQVTELRSR-VQELERALATARQEHTELMEQYKgisrshgEITEERDILSRQQGDHVAR 229
Cdd:PRK03918 355 EELEERHELYEEAKAKKEELERLKKRLTGLtPEKLEKELEELEKAKEEIEEEIS-------KITARIGELKKEIKELKKA 427
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 230 ILELED----------DIQTISEKVLTKE--VELDRLRDTVKALTREQEKLLGQLKEVQ-ADKEQSE--AELQVAQQ--- 291
Cdd:PRK03918 428 IEELKKakgkcpvcgrELTEEHRKELLEEytAELKRIEKELKEIEEKERKLRKELRELEkVLKKESEliKLKELAEQlke 507
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 292 -ENHHLNLDLKEAkswqEEQSAQAQRLKDKVAQMKdtlgqaqqrvAELEPLKEQLRGAQELaassQQKATLLGEELASAa 370
Cdd:PRK03918 508 lEEKLKKYNLEEL----EKKAEEYEKLKEKLIKLK----------GEIKSLKKELEKLEEL----KKKLAELEKKLDEL- 568
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 371 aarDRTIAELHRSRLE-----VAEVNGRLAELG------LHLKEEKcqwsKERAGLLQSVEAEKDKILKLSAEILRLEKA 439
Cdd:PRK03918 569 ---EEELAELLKELEElgfesVEELEERLKELEpfyneyLELKDAE----KELEREEKELKKLEEELDKAFEELAETEKR 641
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 440 VQEERTQNQVFKTELAREKdsslvqLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK 509
Cdd:PRK03918 642 LEELRKELEELEKKYSEEE------YEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEE 705
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
124-517 1.67e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 61.23  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 124 MDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYK 203
Cdd:PRK03918 371 KEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHR 450
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 204 G--ISRSHGEIteeRDILSRqqgdhVARILELEDDIQ---TISEKVLTKEVELDRLRDTVKALTREQEKLLG-QLKEVQA 277
Cdd:PRK03918 451 KelLEEYTAEL---KRIEKE-----LKEIEEKERKLRkelRELEKVLKKESELIKLKELAEQLKELEEKLKKyNLEELEK 522
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 278 DKEQSE---AELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAE-LEPLKEQLrgaQELAA 353
Cdd:PRK03918 523 KAEEYEklkEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFEsVEELEERL---KELEP 599
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 354 SSQQKATLLG--EELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERagllqsVEAEKDKILKLSA 431
Cdd:PRK03918 600 FYNEYLELKDaeKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEE------YEELREEYLELSR 673
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 432 EILRLEKAVQEERTQNQvfktelarEKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE----ARL 507
Cdd:PRK03918 674 ELAGLRAELEELEKRRE--------EIKKTLEKLKEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKeralSKV 745
                        410
                 ....*....|
gi 767974945 508 EKVADEKWNE 517
Cdd:PRK03918 746 GEIASEIFEE 755
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
251-528 2.25e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 60.84  E-value: 2.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   251 LDRLRDTVKALTREQEKLlgqlkEVQADKEQSEAELQvAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQ 330
Cdd:TIGR02168  188 LDRLEDILNELERQLKSL-----ERQAEKAERYKELK-AELRELELALLVLRLEELREELEELQEELKEAEEELEELTAE 261
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   331 AQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEekcqwsk 410
Cdd:TIGR02168  262 LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDE------- 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   411 eragLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTelarekdsslvQLSESKRELTELRSALRVLQKEKEQLQ 490
Cdd:TIGR02168  335 ----LAEELAELEEKLEELKEELESLEAELEELEAELEELES-----------RLEELEEQLETLRSKVAQLELQIASLN 399
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 767974945   491 EEKQELLEYMRKLEARLEKVADEkwNEDATTEDEEAAV 528
Cdd:TIGR02168  400 NEIERLEARLERLEDRRERLQQE--IEELLKKLEEAEL 435
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
144-372 3.33e-09

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 59.46  E-value: 3.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 144 PKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQykgISRSHGEITEERDILsrqq 223
Cdd:COG3883   16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAE---IAEAEAEIEERREEL---- 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 224 GDHVARILELEDDIQTISEKVLTKEVE--LDRLrDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLK 301
Cdd:COG3883   89 GERARALYRSGGSVSYLDVLLGSESFSdfLDRL-SALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELE 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767974945 302 EAKSWQEEQSAQAQRLkdkVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
Cdd:COG3883  168 AAKAELEAQQAEQEAL---LAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
149-507 3.49e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.17  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQ-LEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDIlsrQQGDHV 227
Cdd:COG4717  175 LQEELEELLEQLSLATEEELQdLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERL---KEARLL 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 228 ARILeleddiqTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQA-DKEQSEAELQVAQQENHHLNLDLKEAKSW 306
Cdd:COG4717  252 LLIA-------AALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLArEKASLGKEAEELQALPALEELEEEELEEL 324
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 307 QEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRgaqeLAASSQQKATLLGE----------ELASAAAARDRT 376
Cdd:COG4717  325 LAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQ----LEELEQEIAALLAEagvedeeelrAALEQAEEYQEL 400
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 377 IAELHRSRLEVAEVNGRLAELGLHLKEEkcQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVfkTELAR 456
Cdd:COG4717  401 KEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGEL--AELLQ 476
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767974945 457 EKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQ-ELLEYMRKLEARL 507
Cdd:COG4717  477 ELEELKAELRELAEEWAALKLALELLEEAREEYREERLpPVLERASEYFSRL 528
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
197-397 3.60e-09

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 60.31  E-value: 3.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  197 ELMEQYKGISRSHGEITEERdilsrQQGDHVARILELEDDIQTISEKVLtkevELDRLRDTVKALTREQEKLLGQLKEVQ 276
Cdd:COG4913   229 ALVEHFDDLERAHEALEDAR-----EQIELLEPIRELAERYAAARERLA----ELEYLRAALRLWFAQRRLELLEAELEE 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  277 ADKEQSEAELQVAQQENHHLNLDLKEA---KSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELE--------PLKEQL 345
Cdd:COG4913   300 LRAELARLEAELERLEARLDALREELDeleAQIRGNGGDRLEQLEREIERLERELEERERRRARLEallaalglPLPASA 379
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767974945  346 RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAEL 397
Cdd:COG4913   380 EEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASL 431
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
150-525 5.06e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 59.67  E-value: 5.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 150 QNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELmeqykgisRSHGEITE-ERDILSRQQGDHVA 228
Cdd:PRK02224 250 REELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDL--------LAEAGLDDaDAEAVEARREELED 321
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQE 308
Cdd:PRK02224 322 RDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 309 EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEP----LKEQLRGAQELAASSqqKATLLGEELASAAAArdRTIAElhrSR 384
Cdd:PRK02224 402 DAPVDLGNAEDFLEELREERDELREREAELEAtlrtARERVEEAEALLEAG--KCPECGQPVEGSPHV--ETIEE---DR 474
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 385 LEVAEVNGRLAELglhlkeekcqwskeragllqsveaeKDKILKLSAEILRLEKAVQEERtqnqvfKTELAREKDSSLVQ 464
Cdd:PRK02224 475 ERVEELEAELEDL-------------------------EEEVEEVEERLERAEDLVEAED------RIERLEERREDLEE 523
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974945 465 LSESKRE-LTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE--KWNEDATTEDEE 525
Cdd:PRK02224 524 LIAERREtIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEvaELNSKLAELKER 587
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
152-512 6.16e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 59.60  E-value: 6.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   152 QLDESQQERNDLMQLKLQLEGQVTELRS---RVQELERALATARQ-----EHTELMEQY-KGISRSHGEITE---ERDIL 219
Cdd:TIGR00618  247 QKREAQEEQLKKQQLLKQLRARIEELRAqeaVLEETQERINRARKaaplaAHIKAVTQIeQQAQRIHTELQSkmrSRAKL 326
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   220 SRQQGDHVARILELEDdiQTISEKVLTKEVELDRLRDTVKALTRE----QEKLLGQLKEVQADKEQSEAELQVAQQENHH 295
Cdd:TIGR00618  327 LMKRAAHVKQQSSIEE--QRRLLQTLHSQEIHIRDAHEVATSIREiscqQHTLTQHIHTLQQQKTTLTQKLQSLCKELDI 404
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   296 LNLDLKEAKSWQEEQSAQAQRL----KDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEElaSAAA 371
Cdd:TIGR00618  405 LQREQATIDTRTSAFRDLQGQLahakKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTK--EQIH 482
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   372 ARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
Cdd:TIGR00618  483 LQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLK 562
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974945   452 TELAREKDSSLV---QLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVAD 512
Cdd:TIGR00618  563 EQMQEIQQSFSIltqCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQD 626
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
152-525 6.95e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 59.21  E-value: 6.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   152 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDhVARIL 231
Cdd:TIGR00618  304 QIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTL-TQHIH 382
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   232 ELEDDIQTISEK--VLTKEVE-LDRLRDTVKALTREQEKLLGQLkevQADKEQSEAELQVAQQENHHLNLDLKEAKSWQE 308
Cdd:TIGR00618  383 TLQQQKTTLTQKlqSLCKELDiLQREQATIDTRTSAFRDLQGQL---AHAKKQQELQQRYAELCAAAITCTAQCEKLEKI 459
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   309 EQSAQAQRLKDKVAQMKDtLGQAQQRVAELEPLKEQLrgAQELAassQQKATLLGEELASAAAARDRTIAELHRSRLE-- 386
Cdd:TIGR00618  460 HLQESAQSLKEREQQLQT-KEQIHLQETRKKAVVLAR--LLELQ---EEPCPLCGSCIHPNPARQDIDNPGPLTRRMQrg 533
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   387 ----------VAEVNGRLAELGLHLKEEKCQWSKERagllQSVEAEKDKILKLSAEILRLEKAVQEERTQNQvfktELAR 456
Cdd:TIGR00618  534 eqtyaqletsEEDVYHQLTSERKQRASLKEQMQEIQ----QSFSILTQCDNRSKEDIPNLQNITVRLQDLTE----KLSE 605
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945   457 EKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNedATTEDEE 525
Cdd:TIGR00618  606 AEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHAL--SIRVLPK 672
PTZ00121 PTZ00121
MAEBL; Provisional
245-526 1.12e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  245 LTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEaELQVAQQENhhlnlDLKEAKSWQEEQSAQAQRLKDKVAQM 324
Cdd:PTZ00121 1475 AKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD-EAKKAEEAK-----KADEAKKAEEAKKADEAKKAEEKKKA 1548
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  325 KDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAtllgEELASAAAARDRTIAELHRSRLEVAEVNGRlaelglhlKEE 404
Cdd:PTZ00121 1549 DELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKA----EEAKKAEEARIEEVMKLYEEEKKMKAEEAK--------KAE 1616
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  405 KCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDsslvqlsESKRELTELRSALRVLQK 484
Cdd:PTZ00121 1617 EAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE-------EDKKKAEEAKKAEEDEKK 1689
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 767974945  485 EKEQLQEEKQEL--LEYMRKLEARLEKVADE--KWNEDATTEDEEA 526
Cdd:PTZ00121 1690 AAEALKKEAEEAkkAEELKKKEAEEKKKAEElkKAEEENKIKAEEA 1735
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
228-548 1.12e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 58.70  E-value: 1.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   228 ARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEvqadkeqseAELQVAQQENHHLNLDLKEAKSWQ 307
Cdd:pfam12128  604 ERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKN---------ARLDLRRLFDEKQSEKDKKNKALA 674
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   308 EEQSAQAQRLKDKVAQMKDTLGQAQqrvAELEPLKEQLRgaqELAASSQQKATLLGEELASAAAARDRTIAELHRSRlev 387
Cdd:pfam12128  675 ERKDSANERLNSLEAQLKQLDKKHQ---AWLEEQKEQKR---EARTEKQAYWQVVEGALDAQLALLKAAIAARRSGA--- 745
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   388 aevngrlaelglhlKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAV-------QEERTQNQVFKTELAREKDS 460
Cdd:pfam12128  746 --------------KAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIeriavrrQEVLRYFDWYQETWLQRRPR 811
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   461 SLVQLSESKRELTELRSALRVLQK---------EKEQLQEEKQ--ELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVG 529
Cdd:pfam12128  812 LATQLSNIERAISELQQQLARLIAdtklrraklEMERKASEKQqvRLSENLRGLRCEMSKLATLKEDANSEQAQGSIGER 891
                          330
                   ....*....|....*....
gi 767974945   530 LSCPAALTDSEDESPEDMR 548
Cdd:pfam12128  892 LAQLEDLKLKRDYLSESVK 910
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
145-514 1.98e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 1.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQG 224
Cdd:COG1196  394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 225 DHVARILELEDDIQTISEKVLTKEVELDRLR---DTVKALTRE--QEKLLGQLKEVQADKEQSEAELQVA-----QQENH 294
Cdd:COG1196  474 LLEAALAELLEELAEAAARLLLLLEAEADYEgflEGVKAALLLagLRGLAGAVAVLIGVEAAYEAALEAAlaaalQNIVV 553
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 295 HLNLDLKEAKSWQEEQSAQA-------QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELA 367
Cdd:COG1196  554 EDDEVAAAAIEYLKAAKAGRatflpldKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLE 633
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 368 SAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQN 447
Cdd:COG1196  634 AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAE 713
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 448 QVFKTELAR-------------------------------EKDSSLVQLSESKRELTELRSALRVL-------------- 482
Cdd:COG1196  714 EERLEEELEeealeeqleaereelleelleeeelleeealEELPEPPDLEELERELERLEREIEALgpvnllaieeyeel 793
                        410       420       430
                 ....*....|....*....|....*....|..
gi 767974945 483 QKEKEQLQEEKQELLEYMRKLEARLEKVADEK 514
Cdd:COG1196  794 EERYDFLSEQREDLEEARETLEEAIEEIDRET 825
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
145-492 3.72e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.95  E-value: 3.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALataRQEHTELmeqykgisrshgeITEERDILSRQQg 224
Cdd:TIGR04523 322 KLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQREL---EEKQNEI-------------EKLKKENQSYKQ- 384
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  225 dhvaRILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAK 304
Cdd:TIGR04523 385 ----EIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLD 460
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  305 SWQEEQSAQAQRLKDKVAQMKDTLGQAQQ----RVAELEPLKEQLRG-AQELAASSQQKATLLG--EELASAAAARDRTI 377
Cdd:TIGR04523 461 NTRESLETQLKVLSRSINKIKQNLEQKQKelksKEKELKKLNEEKKElEEKVKDLTKKISSLKEkiEKLESEKKEKESKI 540
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  378 AELHRSRLEVAEVNGR--LAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEertqnqvfKTELA 455
Cdd:TIGR04523 541 SDLEDELNKDDFELKKenLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEE--------KEKKI 612
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 767974945  456 REKDSslvQLSESKRELTELRSALRVLQKEKEQLQEE 492
Cdd:TIGR04523 613 SSLEK---ELEKAKKENEKLSSIIKNIKSKKNKLKQE 646
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
149-292 3.96e-08

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.55  E-value: 3.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDI--LSRQQGDH 226
Cdd:COG1579   22 LEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYeaLQKEIESL 101
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767974945 227 VARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQE 292
Cdd:COG1579  102 KRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREE 167
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
149-528 5.25e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 5.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELM-------EQYKGISRSH------------ 209
Cdd:pfam15921  115 LQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKCLKEDMLedsntqiEQLRKMMLSHegvlqeirsilv 194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   210 ------GEITEERDILS----RQQGDHVARIL-ELEDDIQTISEKVLTKEVELdrlrDTVKALTREQEKLLGQLKEVQAD 278
Cdd:pfam15921  195 dfeeasGKKIYEHDSMStmhfRSLGSAISKILrELDTEISYLKGRIFPVEDQL----EALKSESQNKIELLLQQHQDRIE 270
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   279 KEQSEAELQVAqqenhhlNLDLKEAKSWQEEQSAQAQrLKDKVAQMKDTLGQAQQRVAELEPLKEQLRgaqelaassqqk 358
Cdd:pfam15921  271 QLISEHEVEIT-------GLTEKASSARSQANSIQSQ-LEIIQEQARNQNSMYMRQLSDLESTVSQLR------------ 330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   359 atllgEELASAAAARDRTIAELHRsrlEVAEVNGRLAElglhLKEEKCQWSKERAGLlqsveaeKDKILKLSAEILRLEK 438
Cdd:pfam15921  331 -----SELREAKRMYEDKIEELEK---QLVLANSELTE----ARTERDQFSQESGNL-------DDQLQKLLADLHKREK 391
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   439 AVQEERTQNqvfKTELAREKDSSLV------QLSESKRELTELRSALRVLQKE-KEQLQEE------KQELLEYMRKLEA 505
Cdd:pfam15921  392 ELSLEKEQN---KRLWDRDTGNSITidhlrrELDDRNMEVQRLEALLKAMKSEcQGQMERQmaaiqgKNESLEKVSSLTA 468
                          410       420       430
                   ....*....|....*....|....*....|
gi 767974945   506 RLE-------KVADEKWNEDATTEDEEAAV 528
Cdd:pfam15921  469 QLEstkemlrKVVEELTAKKMTLESSERTV 498
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
199-520 5.32e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 56.23  E-value: 5.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 199 MEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD 278
Cdd:PRK03918 157 LDDYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEEL 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 279 KEQ-SEAELQVAQQENH--HLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVA-----------------EL 338
Cdd:PRK03918 237 KEEiEELEKELESLEGSkrKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKlsefyeeyldelreiekRL 316
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 339 EPLKEQLRGAQELAASSQQKATLLgEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQS 418
Cdd:PRK03918 317 SRLEEEINGIEERIKELEEKEERL-EELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEE 395
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 419 VEAEK----DKILKLSAEILRLEKAVQEERTQNQ----------VFKTELAREKDSSLV-----QLSESKRELTELRSAL 479
Cdd:PRK03918 396 LEKAKeeieEEISKITARIGELKKEIKELKKAIEelkkakgkcpVCGRELTEEHRKELLeeytaELKRIEKELKEIEEKE 475
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 767974945 480 RVLQKEKEQLQEE---------KQELLEYMRKLEARLEKVADEKWNEDAT 520
Cdd:PRK03918 476 RKLRKELRELEKVlkkeselikLKELAEQLKELEEKLKKYNLEELEKKAE 525
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
147-378 5.56e-08

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.18  E-value: 5.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 147 TVLQNQLDESQQERNDLMQLKLQ-LEGQVTELRSRVQELERALATARQEH--TELMEQYKGISRSHGEITEERDILSRQQ 223
Cdd:COG3206  156 ALAEAYLEQNLELRREEARKALEfLEEQLPELRKELEEAEAALEEFRQKNglVDLSEEAKLLLQQLSELESQLAEARAEL 235
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 224 GDHVARILELEDDIQTISEKV--LTKEVELDRLRDTVKALTREQEKLLGQLKE-----VQADKEQSEAELQVAQqenhhl 296
Cdd:COG3206  236 AEAEARLAALRAQLGSGPDALpeLLQSPVIQQLRAQLAELEAELAELSARYTPnhpdvIALRAQIAALRAQLQQ------ 309
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 297 nldlkEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRT 376
Cdd:COG3206  310 -----EAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEALT 384

                 ..
gi 767974945 377 IA 378
Cdd:COG3206  385 VG 386
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
149-523 1.19e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 55.03  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELEralatarQEHTELMEQykgisrshgeITEERDILSRQQGDHVA 228
Cdd:TIGR04523  45 IKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILE-------QQIKDLNDK----------LKKNKDKINKLNSDLSK 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  229 RILELEDDIQTISekvlTKEVELDRLRDTVKALTREQEKLLGQLKEVQAD--------------KEQSEAEL-----QVA 289
Cdd:TIGR04523 108 INSEIKNDKEQKN----KLEVELNKLEKQKKENKKNIDKFLTEIKKKEKEleklnnkyndlkkqKEELENELnllekEKL 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  290 QQEN------------HHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQrvaELEPLKEQLRGAQelaassQQ 357
Cdd:TIGR04523 184 NIQKnidkiknkllklELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQ---EINEKTTEISNTQ------TQ 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  358 KATLLGEElasaaaarDRTIAELHRSRLEVAEVNGRLAELG----------LHLKEEKCQ-WSKERAGLLQSVEAEKD-- 424
Cdd:TIGR04523 255 LNQLKDEQ--------NKIKKQLSEKQKELEQNNKKIKELEkqlnqlkseiSDLNNQKEQdWNKELKSELKNQEKKLEei 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  425 ---------KILKLSAEILRLEKAVQEERTQNQVFKTELA----------REKDSSLVQLSESKRELTELRSALRVLQKE 485
Cdd:TIGR04523 327 qnqisqnnkIISQLNEQISQLKKELTNSESENSEKQRELEekqneieklkKENQSYKQEIKNLESQINDLESKIQNQEKL 406
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 767974945  486 KEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTED 523
Cdd:TIGR04523 407 NQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKD 444
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
252-494 1.24e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.02  E-value: 1.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 252 DRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDlkeakswqeeqsAQAQRLKDKVAQMKDTLGQA 331
Cdd:COG3206  164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLVDLS------------EEAKLLLQQLSELESQLAEA 231
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 332 QQRVAELEPLKEQLRgaQELAASSQqkatllgeelASAAAARDRTIAELhrsRLEVAEVNGRLAELGLHLKEE-----KC 406
Cdd:COG3206  232 RAELAEAEARLAALR--AQLGSGPD----------ALPELLQSPVIQQL---RAQLAELEAELAELSARYTPNhpdviAL 296
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 407 QwsKERAGLLQSVEAEKDKIL-KLSAEILRLEKAVQEERTQNQVFKTELAREKDSSlVQLSESKRELTELRSALRVLQKE 485
Cdd:COG3206  297 R--AQIAALRAQLQQEAQRILaSLEAELEALQAREASLQAQLAQLEARLAELPELE-AELRRLEREVEVARELYESLLQR 373

                 ....*....
gi 767974945 486 KEQLQEEKQ 494
Cdd:COG3206  374 LEEARLAEA 382
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
145-372 1.44e-07

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 54.45  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI------------------- 205
Cdd:COG3883   31 ELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERaralyrsggsvsyldvllg 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 206 SRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKvltkEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAE 285
Cdd:COG3883  111 SESFSDFLDRLSALSKIADADADLLEELKADKAELEAK----KAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQ 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 286 LQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEE 365
Cdd:COG3883  187 LSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAGAAAGSAGAAG 266

                 ....*..
gi 767974945 366 LASAAAA 372
Cdd:COG3883  267 AAAGAAG 273
mukB PRK04863
chromosome partition protein MukB;
173-506 1.45e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 55.35  E-value: 1.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  173 QVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILS----------RQQGD---HVARILELEDDIQT 239
Cdd:PRK04863  287 EALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASdhlnlvqtalRQQEKierYQADLEELEERLEE 366
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  240 ISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQA--DKEQSEA--------ELQVAQQENHHLNLDLKEAKSWQEE 309
Cdd:PRK04863  367 QNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQalDVQQTRAiqyqqavqALERAKQLCGLPDLTADNAEDWLEE 446
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  310 QSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLR---GAQELAASSQQKATLLGE-----ELASAAAARDRTIAELH 381
Cdd:PRK04863  447 FQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRkiaGEVSRSEAWDVARELLRRlreqrHLAEQLQQLRMRLSELE 526
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  382 RSRLEVAEVNGRLAELG----------LHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFk 451
Cdd:PRK04863  527 QRLRQQQRAERLLAEFCkrlgknlddeDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAW- 605
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767974945  452 telaREKDSSLVQLSE-------SKRELTELRSAL----RVLQKEKEQLQEEKQELLEYMRKLEAR 506
Cdd:PRK04863  606 ----LAAQDALARLREqsgeefeDSQDVTEYMQQLlereRELTVERDELAARKQALDEEIERLSQP 667
Zn-C2H2_CALCOCO1_TAX1BP1_like cd21965
autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil ...
680-703 1.46e-07

autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins; The family includes calcium-binding and coiled-coil domain-containing proteins (CALCOCO1 and CALCOCO2), TAX1BP1 and similar proteins. CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). CALCOCO2, also called antigen nuclear dot 52 kDa protein, or nuclear domain 10 protein NDP52, or nuclear domain 10 protein 52, or nuclear dot protein 52, is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. The family also includes Drosophila melanogaster Spindle-F (Spn-F) that is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. This model corresponds to the C2H2-type zinc binding domain found in family members. It is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.


Pssm-ID: 412012  Cd Length: 24  Bit Score: 47.57  E-value: 1.46e-07
                         10        20
                 ....*....|....*....|....
gi 767974945 680 CPICKERFPAESDKDALEDHMDGH 703
Cdd:cd21965    1 CPICNKQFPPQVDQEAFEDHVESH 24
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
149-528 1.82e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 54.68  E-value: 1.82e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQgdHVA 228
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKL--EEA 433
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAE---LQVAQQENHHLNLDLKEAKS 305
Cdd:TIGR02168  434 ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARldsLERLQENLEGFSEGVKALLK 513
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   306 WQEEQSAQAQRLKDKV-------AQMKDTLGQAQQRVAeLEPLKEQLRGAQELAASSQQKATLLGEELASAAA--ARDRT 376
Cdd:TIGR02168  514 NQSGLSGILGVLSELIsvdegyeAAIEAALGGRLQAVV-VENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEiqGNDRE 592
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   377 IAELHRSRLEVAE------------VNGRLAEL--------GLHL-KEEKCQW-------------------SKERAGLL 416
Cdd:TIGR02168  593 ILKNIEGFLGVAKdlvkfdpklrkaLSYLLGGVlvvddldnALELaKKLRPGYrivtldgdlvrpggvitggSAKTNSSI 672
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   417 QSVEAEKD----KILKLSAEILRLEKAVQEERTQNQVFKTELA---REKDSSLVQLSESKRELTELRSALRVLQKEKEQL 489
Cdd:TIGR02168  673 LERRREIEeleeKIEELEEKIAELEKALAELRKELEELEEELEqlrKELEELSRQISALRKDLARLEAEVEQLEERIAQL 752
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 767974945   490 QEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAV 528
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQI 791
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
185-520 1.83e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.92  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  185 ERALATARQEHTELMEQYKGISRSHGEITEERDILsRQQGDHVARILEL---EDDIQTISEKVLTKEVELDRLR---DTV 258
Cdd:COG4913   609 RAKLAALEAELAELEEELAEAEERLEALEAELDAL-QERREALQRLAEYswdEIDVASAEREIAELEAELERLDassDDL 687
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  259 KALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEE-QSAQAQRLKDKVAQMKDTLGQAQQRVAE 337
Cdd:COG4913   688 AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAaEDLARLELRALLEERFAAALGDAVEREL 767
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  338 LEPLKEQLRGAQELAASSQQKATLL----GEELASAAAARDRTIAELHrsrlEVAEVNGRLAELGLHLKEEKcqWskerA 413
Cdd:COG4913   768 RENLEERIDALRARLNRAEEELERAmrafNREWPAETADLDADLESLP----EYLALLDRLEEDGLPEYEER--F----K 837
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  414 GLLQsvEAEKDKILKLSAEILRLEKAVQEERTQ-NQvfktELAREK---------DSSLVQLSESKRELTELRSALRVLQ 483
Cdd:COG4913   838 ELLN--ENSIEFVADLLSKLRRAIREIKERIDPlND----SLKRIPfgpgrylrlEARPRPDPEVREFRQELRAVTSGAS 911
                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 767974945  484 KEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDAT 520
Cdd:COG4913   912 LFDEELSEARFAALKRLIERLRSEEEESDRRWRARVL 948
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
130-514 3.50e-07

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 53.69  E-value: 3.50e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   130 LEEADGGSDILLVVPKATVLQNQ-----------------------LDESQQER-----NDLMQLKLQLEGQVTELRSRV 181
Cdd:pfam12128  227 IRDIQAIAGIMKIRPEFTKLQQEfntlesaelrlshlhfgyksdetLIASRQEErqetsAELNQLLRTLDDQWKEKRDEL 306
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   182 -QELERALA--TARQEHTELMEQYKG------ISRSHGEitEERDILSRQQGDHVARILE-LEDDIQTISEKvlTKEVEL 251
Cdd:pfam12128  307 nGELSAADAavAKDRSELEALEDQHGafldadIETAAAD--QEQLPSWQSELENLEERLKaLTGKHQDVTAK--YNRRRS 382
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   252 DRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQE-NHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQM---KDT 327
Cdd:pfam12128  383 KIKEQNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALESElREQLEAGKLEFNEEEYRLKSRLGELKLRLNQAtatPEL 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   328 LGQAQQRVAELEPLKEqlrgAQELAASSQQKATLlgeELASAAAARDRTIAELHRSRLEVAEVNGRLAELGL-------- 399
Cdd:pfam12128  463 LLQLENFDERIERARE----EQEAANAEVERLQS---ELRQARKRRDQASEALRQASRRLEERQSALDELELqlfpqagt 535
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   400 ---HLKEEKCQWSKERAGLLQS------------VEAEKDKILKL-----------------SAEILRLEKAVQEERTQN 447
Cdd:pfam12128  536 llhFLRKEAPDWEQSIGKVISPellhrtdldpevWDGSVGGELNLygvkldlkridvpewaaSEEELRERLDKAEEALQS 615
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945   448 QvfkTELAREKDSSLVQLS----ESKRELTELRSA-------LRVLQKEKEQLQEEKQELL-EYMRKLEARLEKVADEK 514
Cdd:pfam12128  616 A---REKQAAAEEQLVQANgeleKASREETFARTAlknarldLRRLFDEKQSEKDKKNKALaERKDSANERLNSLEAQL 691
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
228-400 3.56e-07

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 52.81  E-value: 3.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  228 ARILELEDDIQTISEKVLTKEVELDRLRdtvkALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
Cdd:pfam00529  58 AALDSAEAQLAKAQAQVARLQAELDRLQ----ALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLA 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  308 EEQSAQAQRL---KDKVAQMKDTLGQAQQRVAELEPLKEQLrgAQELAAssQQKATLLGEELASAAAARDRTIAELHRSR 384
Cdd:pfam00529 134 PIGGISRESLvtaGALVAQAQANLLATVAQLDQIYVQITQS--AAENQA--EVRSELSGAQLQIAEAEAELKLAKLDLER 209
                         170
                  ....*....|....*..
gi 767974945  385 LEV-AEVNGRLAELGLH 400
Cdd:pfam00529 210 TEIrAPVDGTVAFLSVT 226
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
317-514 3.62e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.62  E-value: 3.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 317 LKDKVAQMKDTLGQAQQR-----VAELEPLKEQLRGAQELAASSQQKAtllgEELASAAAARDRTIAELHRSRLEVAEVN 391
Cdd:COG4717   47 LLERLEKEADELFKPQGRkpelnLKELKELEEELKEAEEKEEEYAELQ----EELEELEEELEELEAELEELREELEKLE 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 392 GRLAELGLHLKEEKCQwsKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRE 471
Cdd:COG4717  123 KLLQLLPLYQELEALE--AELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEE 200
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767974945 472 LTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK 514
Cdd:COG4717  201 LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEE 243
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
165-525 3.70e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 53.82  E-value: 3.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   165 QLKLQLEGQVTELRSRVQELERALATARQEhteLMEQYKGISRshgeiTEERDILSRQQGDHV--ARILELEDDIQTISE 242
Cdd:pfam02463  668 LSELTKELLEIQELQEKAESELAKEEILRR---QLEIKKKEQR-----EKEELKKLKLEAEELlaDRVQEAQDKINEELK 739
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   243 KVLTK--EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHH-LNLDLKEAKSWQEEQSAQAQRLKd 319
Cdd:pfam02463  740 LLKQKidEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEkLKAQEEELRALEEELKEEAELLE- 818
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   320 kvAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAA------AARDRTIAELHRSRLEVAEVNGR 393
Cdd:pfam02463  819 --EEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEEllqellLKEEELEEQKLKDELESKEEKEK 896
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   394 LAELGLHLKEEKCQWSKERAGLLQSVEAEKDKIL-KLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKREL 472
Cdd:pfam02463  897 EEKKELEEESQKLNLLEEKENEIEERIKEEAEILlKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVN 976
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   473 TELRSALRVLQK-------EKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEE 525
Cdd:pfam02463  977 LMAIEEFEEKEErynkdelEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSINKGWNKV 1036
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
258-512 4.55e-07

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 53.51  E-value: 4.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 258 VKALTREQEKLLGQLKEVQADKEQSE--AELQVAQQENHHLNLDLKEAkswqEEQSAQAQRLKDkvaQMKDTLGQAQQRV 335
Cdd:PRK02224 178 VERVLSDQRGSLDQLKAQIEEKEEKDlhERLNGLESELAELDEEIERY----EEQREQARETRD---EADEVLEEHEERR 250
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 336 AELEPLKEQLRGAQELAASSQQKATLLGEELASA-------AAARDRTIAELHRSRLEVAEVNGRLAElgLHLKEEKCQW 408
Cdd:PRK02224 251 EELETLEAEIEDLRETIAETEREREELAEEVRDLrerleelEEERDDLLAEAGLDDADAEAVEARREE--LEDRDEELRD 328
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 409 SKERAGLlqSVEAEKDKILKLSAEILRLEKAVQEERTQnqvfKTELAREKDSSLVQLSESKRELTELRSALRVLQKE--- 485
Cdd:PRK02224 329 RLEECRV--AAQAHNEEAESLREDADDLEERAEELREE----AAELESELEEAREAVEDRREEIEELEEEIEELRERfgd 402
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 767974945 486 -----------KEQLQEEKQELLEYMRKLEARLEKVAD 512
Cdd:PRK02224 403 apvdlgnaedfLEELREERDELREREAELEATLRTARE 440
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
152-540 4.70e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.38  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  152 QLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-RSHGEITEERDILSRQQGDHVARI 230
Cdd:COG4913   282 RLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERERRR 361
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  231 LELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQvaqqenhhlnldlKEAKSWQEEQ 310
Cdd:COG4913   362 ARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLR-------------RELRELEAEI 428
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  311 SAQAQR---LKDKVAQMKDTLGQAQQR-------VAEL---EPLKEQLRGAQELAASSqQKATLL--------------- 362
Cdd:COG4913   429 ASLERRksnIPARLLALRDALAEALGLdeaelpfVGELievRPEEERWRGAIERVLGG-FALTLLvppehyaaalrwvnr 507
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  363 --------------GEELASAAAARDRTIAElhrsRLEVAE------VNGRLAELGLHLK----EE--KCQWSKERAGLL 416
Cdd:COG4913   508 lhlrgrlvyervrtGLPDPERPRLDPDSLAG----KLDFKPhpfrawLEAELGRRFDYVCvdspEElrRHPRAITRAGQV 583
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  417 QSVEA--EKD-----------------KILKLSAEILRLEKAVQEERTQNQVFKTELA---------------------- 455
Cdd:COG4913   584 KGNGTrhEKDdrrrirsryvlgfdnraKLAALEAELAELEEELAEAEERLEALEAELDalqerrealqrlaeyswdeidv 663
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  456 -------REKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEkwnEDATTEDEEAAV 528
Cdd:COG4913   664 asaereiAELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE---LDELQDRLEAAE 740
                         490
                  ....*....|..
gi 767974945  529 GLSCPAALTDSE 540
Cdd:COG4913   741 DLARLELRALLE 752
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
149-513 8.74e-07

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 52.38  E-value: 8.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELerALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:COG4192   39 LSNQIRYILDDSLPKLQASLKLEENSNELVAALPEF--AAATNTTERSQLRNQLNTQLADIEELLAELEQLTQDAGDLRA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 229 RILELEDDIQtisekvltkevELDRLRDTVKALTREQEKLLGQLKEVQAD-KEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
Cdd:COG4192  117 AVADLRNLLQ-----------QLDSLLTQRIALRRRLQELLEQINWLHQDfNSELTPLLQEASWQQTRLLDSVETTESLR 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 308 EEQSA--QAQRLKDKVAQMKDTLGQ-AQQR-VAELEPLKEQLrgaQELAASSQQKATLLGEelASAAAARDRTIAELhrs 383
Cdd:COG4192  186 NLQNElqLLLRLLAIENQIVSLLREvAAARdQADVDNLFDRL---QYLKDELDRNLQALKN--YPSTITLRQLIDEL--- 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 384 rLEVAEVNGRLAEL---GLHLKEEkcqwskeraglLQSVEAEKDKILKLSAEilRLEKAVQEERTQNQVFKTELAREKDS 460
Cdd:COG4192  258 -LAIGSGEGGLPSLrrdELAAQAT-----------LEALAEENNSILEQLRT--QISGLVGNSREQLVALNQETAQLVQQ 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 461 S------------------------------LVQLSES-----------------KRELTELRSALRV-LQKEKEQLQEE 492
Cdd:COG4192  324 SgilllaiallslllavlinyfyvrrrlvkrLNALSDAmaaiaagdldvpipvdgNDEIGRIARLLRVfRDQAIEKTQEL 403
                        410       420
                 ....*....|....*....|.
gi 767974945 493 KQELLEYMRkLEARLEKVADE 513
Cdd:COG4192  404 ETEIEERKR-IEKNLRQTQDE 423
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
147-506 1.82e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.33  E-value: 1.82e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   147 TVLQNQLD-------ESQQERNDLMQLKLQLEGQVTELRSRVQELERalaTARQEHTELMEQYKGISRSHGEITEERDIL 219
Cdd:pfam01576   43 NALQEQLQaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEE---RSQQLQNEKKKMQQHIQDLEEQLDEEEAAR 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   220 SRQQGDHV---ARILELEDDIQTISEK--VLTKEVEL--DRLRDTVKALTREQEKlLGQLKEVQADKEQSEAELQVAQQE 292
Cdd:pfam01576  120 QKLQLEKVtteAKIKKLEEDILLLEDQnsKLSKERKLleERISEFTSNLAEEEEK-AKSLSKLKNKHEAMISDLEERLKK 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   293 NHHLNLDLKEAKSWQEEQSAQAQ-RLKDKVAQMKDTLGQAQQRVAELEPLkeQLRGAQELAASSQQKATL---------L 362
Cdd:pfam01576  199 EEKGRQELEKAKRKLEGESTDLQeQIAELQAQIAELRAQLAKKEEELQAA--LARLEEETAQKNNALKKIreleaqiseL 276
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   363 GEELASAAAARDRtiAELHRSRLEvaevngrlaelglhlkEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQE 442
Cdd:pfam01576  277 QEDLESERAARNK--AEKQRRDLG----------------EELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEE 338
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974945   443 ERTQNQVFKTELAREKDSSLVQLSEskrELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
Cdd:pfam01576  339 ETRSHEAQLQEMRQKHTQALEELTE---QLEQAKRNKANLEKAKQALESENAELQAELRTLQQA 399
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
232-517 1.84e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 51.51  E-value: 1.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   232 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQvAQQENHHLNLDLKEAKSWQEEQS 311
Cdd:TIGR00618  191 SLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLT-QKREAQEEQLKKQQLLKQLRARI 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   312 AQAQRLKDKVAQMKDTLGQAQQR---VAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVA 388
Cdd:TIGR00618  270 EELRAQEAVLEETQERINRARKAaplAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQT 349
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   389 -----EVNGRLAELGLHLKEEKCQWSKERAGLLQSVE-----AEKDKILKLSAEILRLEKAVQEERTQNQ--------VF 450
Cdd:TIGR00618  350 lhsqeIHIRDAHEVATSIREISCQQHTLTQHIHTLQQqkttlTQKLQSLCKELDILQREQATIDTRTSAFrdlqgqlaHA 429
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945   451 KTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL--LEYMRKLEARLEKVADEKWNE 517
Cdd:TIGR00618  430 KKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLqtKEQIHLQETRKKAVVLARLLE 498
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
149-508 1.93e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.33  E-value: 1.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEiTEERDILSRQQGDHVA 228
Cdd:pfam01576  389 LQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNE-AEGKNIKLSKDVSSLE 467
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   229 RilELEDDIQTISEKVLTKEVELDRLRdtvkALTREQEKLLGQLKEVQADKEQSEAELQVAQQ---------ENHHLNLD 299
Cdd:pfam01576  468 S--QLQDTQELLQEETRQKLNLSTRLR----QLEDERNSLQEQLEEEEEAKRNVERQLSTLQAqlsdmkkklEEDAGTLE 541
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   300 LKEA--KSWQEEQSAQAQRLKDKVAQMkDTLGQAQQRV-AELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRT 376
Cdd:pfam01576  542 ALEEgkKRLQRELEALTQQLEEKAAAY-DKLEKTKNRLqQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARY 620
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   377 IAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSK-ERAGLLQSVEAE-----KDKILKLSAEILR----LEKAVQEERTQ 446
Cdd:pfam01576  621 AEERDRAEAEAREKETRALSLARALEEALEAKEElERTNKQLRAEMEdlvssKDDVGKNVHELERskraLEQQVEEMKTQ 700
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767974945   447 NQVFKTELAREKDSSL---VQLSESKRELTelrsalRVLQKEKEQLQEEKQELLEYMRKLEARLE 508
Cdd:pfam01576  701 LEELEDELQATEDAKLrleVNMQALKAQFE------RDLQARDEQGEEKRRQLVKQVRELEAELE 759
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
206-498 2.24e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.07  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  206 SRSHGEITEERDILSRQQ--GDHVARILELEDDIQTISEkvltkevELDRLRDTVKALTREQEKLLGQLKEVQADKEQSE 283
Cdd:COG4913   586 NGTRHEKDDRRRIRSRYVlgFDNRAKLAALEAELAELEE-------ELAEAEERLEALEAELDALQERREALQRLAEYSW 658
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  284 AELQVAQQENHHLNLdlkeakswqEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLG 363
Cdd:COG4913   659 DEIDVASAEREIAEL---------EAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEEL 729
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  364 EELASAAAARDRTIAELHRSRLEvaevnGRLAELGLhlkeekcqwSKERAGLLQSVEAEKDkilKLSAEILRLEKAVQEE 443
Cdd:COG4913   730 DELQDRLEAAEDLARLELRALLE-----ERFAAALG---------DAVERELRENLEERID---ALRARLNRAEEELERA 792
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767974945  444 RTQ-NQVFKTElAREKDSSLVQLSESKRELTELR-SAL-RVLQKEKEQLQEEKQELLE 498
Cdd:COG4913   793 MRAfNREWPAE-TADLDADLESLPEYLALLDRLEeDGLpEYEERFKELLNENSIEFVA 849
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
219-508 2.43e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 50.29  E-value: 2.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 219 LSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKE-------VQADKEQSEAELQVAQQ 291
Cdd:COG4372   29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEElneqlqaAQAELAQAQEELESLQE 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 292 ENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEplkeqlrgaQELAASSQQKATLLGEELASAAA 371
Cdd:COG4372  109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELE---------EQLESLQEELAALEQELQALSEA 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 372 ARDRTIAELhrsrleVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK 451
Cdd:COG4372  180 EAEQALDEL------LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLE 253
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767974945 452 TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE 508
Cdd:COG4372  254 EVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLI 310
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
147-513 3.11e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.83  E-value: 3.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   147 TVLQNQLDESQQERNDLMQLKLQLEgqvtELRSRVQELERALATARQEHTELME-----QYKGISRSHGEITEERDILSR 221
Cdd:TIGR02168  379 EQLETLRSKVAQLELQIASLNNEIE----RLEARLERLEDRRERLQQEIEELLKkleeaELKELQAELEELEEELEELQE 454
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   222 QQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLG------QLKEVQAD--------------KEQ 281
Cdd:TIGR02168  455 ELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegvkALLKNQSGlsgilgvlselisvDEG 534
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   282 SEAELQVAQQEnHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMK-DTLGQAQQRVAELEPLKEQ---------------- 344
Cdd:TIGR02168  535 YEAAIEAALGG-RLQAVVVENLNAAKKAIAFLKQNELGRVTFLPlDSIKGTEIQGNDREILKNIegflgvakdlvkfdpk 613
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   345 -----------------LRGAQELAASSQQKA---TLLGEEL----ASAAAARDRTIAELHRSRlEVAEVNGRLAELGLH 400
Cdd:TIGR02168  614 lrkalsyllggvlvvddLDNALELAKKLRPGYrivTLDGDLVrpggVITGGSAKTNSSILERRR-EIEELEEKIEELEEK 692
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   401 LKEEKcqwsKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDsslvQLSESKRELTELRSALR 480
Cdd:TIGR02168  693 IAELE----KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEE----RIAQLSKELTELEAEIE 764
                          410       420       430
                   ....*....|....*....|....*....|...
gi 767974945   481 VLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 513
Cdd:TIGR02168  765 ELEERLEEAEEELAEAEAEIEELEAQIEQLKEE 797
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
158-525 4.50e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 50.11  E-value: 4.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  158 QERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGIS-RSHGEITEERDILSRQQGD-HVARILEleD 235
Cdd:pfam05483  85 KEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSlKLEEEIQENKDLIKENNATrHLCNLLK--E 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  236 DIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENH----HLNLDLKEAKSWQEEQ- 310
Cdd:pfam05483 163 TCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHekiqHLEEEYKKEINDKEKQv 242
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  311 SAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEV 390
Cdd:pfam05483 243 SLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIA 322
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  391 NGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSaEILRLEKA-VQEERTQNQVFKTELaREKDSSLVQLSESK 469
Cdd:pfam05483 323 TKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLE-ELLRTEQQrLEKNEDQLKIITMEL-QKKSSELEEMTKFK 400
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  470 R----ELTELRSAL----------RVLQKEKEQLQEEKQELLEYmrkLEARLEKVADEKWNEDATTEDEE 525
Cdd:pfam05483 401 NnkevELEELKKILaedeklldekKQFEKIAEELKGKEQELIFL---LQAREKEIHDLEIQLTAIKTSEE 467
PTZ00121 PTZ00121
MAEBL; Provisional
171-526 5.23e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 5.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  171 EGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHgEITEERDILSRQQGDHVARILELE--DDIQTISEKVLTKE 248
Cdd:PTZ00121 1132 EARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEAR-KAEDAKKAEAARKAEEVRKAEELRkaEDARKAEAARKAEE 1210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  249 VeldrlRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAK-----SWQEEQSAQAQRLKDKVAQ 323
Cdd:PTZ00121 1211 E-----RKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARmahfaRRQAAIKAEEARKADELKK 1285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  324 MK-----DTLGQAQQ--RVAELEPLKEQLRGAQEL---AASSQQKATLLGE--ELASAAAARDRTIAELHRSRLEVAEVN 391
Cdd:PTZ00121 1286 AEekkkaDEAKKAEEkkKADEAKKKAEEAKKADEAkkkAEEAKKKADAAKKkaEEAKKAAEAAKAEAEAAADEAEAAEEK 1365
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  392 GRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRE 471
Cdd:PTZ00121 1366 AEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKK 1445
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767974945  472 LTELRSalrvlQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
Cdd:PTZ00121 1446 ADEAKK-----KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEA 1495
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
147-289 6.59e-06

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 48.60  E-value: 6.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  147 TVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALA----TARQEHTELMEQYKGISRSHGEITEE------- 215
Cdd:pfam09787  43 TALTLELEELRQERDLLREEIQKLRGQIQQLRTELQELEAQQQeeaeSSREQLQELEEQLATERSARREAEAElerlqee 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  216 ----RDILSRQQGDHVARILELEDDIQTISEKVLTK------EVELD-RLRD----------TVKALTREQEKLLGQLK- 273
Cdd:pfam09787 123 lrylEEELRRSKATLQSRIKDREAEIEKLRNQLTSKsqssssQSELEnRLHQltetliqkqtMLEALSTEKNSLVLQLEr 202
                         170
                  ....*....|....*..
gi 767974945  274 -EVQADKEQSEAELQVA 289
Cdd:pfam09787 203 mEQQIKELQGEGSNGTS 219
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
162-525 6.93e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.79  E-value: 6.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   162 DLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHgeiteERDILSR-QQGDHVARIL--------- 231
Cdd:pfam01576  682 ELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQF-----ERDLQARdEQGEEKRRQLvkqvrelea 756
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   232 ELEDDIQTISEKVLTK---EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQseaelqvaqqenhhLNLDLKEAKSWQE 308
Cdd:pfam01576  757 ELEDERKQRAQAVAAKkklELDLKELEAQIDAANKGREEAVKQLKKLQAQMKD--------------LQRELEEARASRD 822
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   309 EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQlrgaqelaasSQQKATLLGEELASAAAARDRTIAElhRSRLEva 388
Cdd:pfam01576  823 EILAQSKESEKKLKNLEAELLQLQEDLAASERARRQ----------AQQERDELADEIASGASGKSALQDE--KRRLE-- 888
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   389 evnGRLAELGLHLKEEKCqwskeragllqSVEAEKDKILKLSAEILRLEKAVQEERTQNQvfKTELAREKDSSlvQLSES 468
Cdd:pfam01576  889 ---ARIAQLEEELEEEQS-----------NTELLNDRLRKSTLQVEQLTTELAAERSTSQ--KSESARQQLER--QNKEL 950
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945   469 KRELTELRSALRVLQKE------------KEQLQEEKQElleymRKLEARLEKVADEKWNEDATTEDEE 525
Cdd:pfam01576  951 KAKLQEMEGTVKSKFKSsiaaleakiaqlEEQLEQESRE-----RQAANKLVRRTEKKLKEVLLQVEDE 1014
mukB PRK04863
chromosome partition protein MukB;
171-492 9.45e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.19  E-value: 9.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  171 EGQVTELRSRVQELERALATARQEHTELMEQYKgisrshgEITEERDILSRqqgdHVARILELEDDiqTISEKVLTKEVE 250
Cdd:PRK04863  836 EAELRQLNRRRVELERALADHESQEQQQRSQLE-------QAKEGLSALNR----LLPRLNLLADE--TLADRVEEIREQ 902
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  251 LDRLRDTvKALTREQEKLLGQLkevqadkEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDkVAQMKDTLG- 329
Cdd:PRK04863  903 LDEAEEA-KRFVQQHGNALAQL-------EPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTE-VVQRRAHFSy 973
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  330 -QAQQRVAELEPLKEQLRGAQELAassQQKATLLGEELASAAA-ARDRT------IAELHRSRLEVAEVNGRLAELGLHL 401
Cdd:PRK04863  974 eDAAEMLAKNSDLNEKLRQRLEQA---EQERTRAREQLRQAQAqLAQYNqvlaslKSSYDAKRQMLQELKQELQDLGVPA 1050
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  402 KEEkcqwSKERAGLLQSveaekdkilklsaeilRLEKAVQEERTQnqvfktelareKDSSLVQLSESKRELTELRSALRV 481
Cdd:PRK04863 1051 DSG----AEERARARRD----------------ELHARLSANRSR-----------RNQLEKQLTFCEAEMDNLTKKLRK 1099
                         330
                  ....*....|.
gi 767974945  482 LQKEKEQLQEE 492
Cdd:PRK04863 1100 LERDYHEMREQ 1110
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
149-527 1.24e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 48.63  E-value: 1.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:pfam01576  108 LEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEA 187
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   229 RILELEDDIQTiSEKVLTKEVELDRLRDTVKALTREQ-EKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
Cdd:pfam01576  188 MISDLEERLKK-EEKGRQELEKAKRKLEGESTDLQEQiAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKI 266
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   308 EEQSAQAQRLKDKVAQMKDTLGQAQQRV----AELEPLKEQLRGA-------QELAASSQQKATLLGEELASAAAARDRT 376
Cdd:pfam01576  267 RELEAQISELQEDLESERAARNKAEKQRrdlgEELEALKTELEDTldttaaqQELRSKREQEVTELKKALEEETRSHEAQ 346
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   377 IAELHR----------SRLEVAEVN-GRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLE-KAVQEER 444
Cdd:pfam01576  347 LQEMRQkhtqaleeltEQLEQAKRNkANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQaRLSESER 426
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   445 TQNQ----VFKTELAREKDSSLVQLSESK--RELTELRSALRVLQKEKEQLQEEKQELLeymrKLEARLEKVADEKWNED 518
Cdd:pfam01576  427 QRAElaekLSKLQSELESVSSLLNEAEGKniKLSKDVSSLESQLQDTQELLQEETRQKL----NLSTRLRQLEDERNSLQ 502

                   ....*....
gi 767974945   519 ATTEDEEAA 527
Cdd:pfam01576  503 EQLEEEEEA 511
PTZ00121 PTZ00121
MAEBL; Provisional
245-518 1.39e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  245 LTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL-DLKEAKSWQEEQSAQAQRLKDKVAQ 323
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALrKAEEAKKAEEARIEEVMKLYEEEKK 1606
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  324 MKdtlgQAQQRVAELEPLK-EQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEV--AEVNGRLAELGLh 400
Cdd:PTZ00121 1607 MK----AEEAKKAEEAKIKaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAkkAEEDKKKAEEAK- 1681
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  401 lKEEKCQWSKERAGLLQSVEAEK-DKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDsslvqlsESKRELTELRsal 479
Cdd:PTZ00121 1682 -KAEEDEKKAAEALKKEAEEAKKaEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAE-------EDKKKAEEAK--- 1750
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 767974945  480 rVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED 518
Cdd:PTZ00121 1751 -KDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEE 1788
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
241-513 1.70e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 48.41  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  241 SEKVLTKEVELdrlRDTVKALTREQEKLL---GQLKEVQADKEQSEAELQVAqqeNHHLNLDLkeakswqeeqsaQAQRL 317
Cdd:COG3096   284 SERALELRREL---FGARRQLAEEQYRLVemaRELEELSARESDLEQDYQAA---SDHLNLVQ------------TALRQ 345
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  318 KDKVAQMKDTLGQAQQRVAE----LEPLKEQLRGAQELAASSQQKAtllgEELASAAAARDRTIAELHR---------SR 384
Cdd:COG3096   346 QEKIERYQEDLEELTERLEEqeevVEEAAEQLAEAEARLEAAEEEV----DSLKSQLADYQQALDVQQTraiqyqqavQA 421
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  385 LEVAEVNGRLAELGLHLKEEKCQWSKERAGLL-QSVEAEKDKILKLSAEILRLEKAVQE--------ERTQNQVFKTEL- 454
Cdd:COG3096   422 LEKARALCGLPDLTPENAEDYLAAFRAKEQQAtEEVLELEQKLSVADAARRQFEKAYELvckiagevERSQAWQTARELl 501
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767974945  455 --AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQE----------EKQELLEYMRKLEARLEKVADE 513
Cdd:COG3096   502 rrYRSQQALAQRLQQLRAQLAELEQRLRQQQNAERLLEEfcqrigqqldAAEELEELLAELEAQLEELEEQ 572
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
375-528 1.83e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.84  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 375 RTIAELHRSRLEVAEVNGRLAELGLHLKEEKcqwsKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTEL 454
Cdd:COG1579    7 RALLDLQELDSELDRLEHRLKELPAELAELE----DELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945 455 -----AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAV 528
Cdd:COG1579   83 gnvrnNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEEL 161
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
149-444 1.97e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.59  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVA 228
Cdd:COG4372   50 LREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQ 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 229 RILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQE 308
Cdd:COG4372  130 QRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLI 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 309 EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVA 388
Cdd:COG4372  210 ESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALE 289
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767974945 389 EVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
Cdd:COG4372  290 EAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQL 345
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
158-492 1.98e-05

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 47.98  E-value: 1.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  158 QERNDLMQLKLQLEGQVTELRSR----VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQqgdhvariLEL 233
Cdd:pfam15964 307 KERDDLMSALVSVRSSLAEAQQRessaYEQVKQAVQMTEEANFEKTKALIQCEQLKSELERQKERLEKE--------LAS 378
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  234 EDDIQTISEKVLTKEVELDR--LRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQS 311
Cdd:pfam15964 379 QQEKRAQEKEALRKEMKKEReeLGATMLALSQNVAQLEAQVEKVTREKNSLVSQLEEAQKQLASQEMDVTKVCGEMRYQL 458
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  312 AQAQRLKDKVAQ-----MKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 386
Cdd:pfam15964 459 NQTKMKKDEAEKehreyRTKTGRQLEIKDQEIEKLGLELSESKQRLEQAQQDAARAREECLKLTELLGESEHQLHLTRLE 538
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  387 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKA----VQEERTQNQVFKTELAREKDSSL 462
Cdd:pfam15964 539 KESIQQSFSNEAKAQALQAQQREQELTQKMQQMEAQHDKTVNEQYSLLTSQNTfiakLKEECCTLAKKLEEITQKSRSEV 618
                         330       340       350
                  ....*....|....*....|....*....|
gi 767974945  463 VQLSESKRELTElrsALRVLQKEKEQLQEE 492
Cdd:pfam15964 619 EQLSQEKEYLQD---RLEKLQKRNEELEEQ 645
PTZ00121 PTZ00121
MAEBL; Provisional
176-524 2.05e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  176 ELRsRVQELERALATARQEHTELMEQYKGISRSHgEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLR 255
Cdd:PTZ00121 1192 ELR-KAEDARKAEAARKAEEERKAEEARKAEDAK-KAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQ 1269
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  256 DTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLK---EAKSWQEEQSAQAQRLKDKVAQMKDtlgQAQ 332
Cdd:PTZ00121 1270 AAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKkadEAKKKAEEAKKKADAAKKKAEEAKK---AAE 1346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  333 QRVAELEPLKEQLRGAQELAASSQQKATllgEELASAAAARDRtiAELHRSRLEV---AEVNGRLAElglHLKEEKCQWS 409
Cdd:PTZ00121 1347 AAKAEAEAAADEAEAAEEKAEAAEKKKE---EAKKKADAAKKK--AEEKKKADEAkkkAEEDKKKAD---ELKKAAAAKK 1418
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  410 KERAGLLQSVEAEKDKILKLSAEILR----LEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKE 485
Cdd:PTZ00121 1419 KADEAKKKAEEKKKADEAKKKAEEAKkadeAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKK 1498
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 767974945  486 KEQLQ--EEKQELLEYMRKLEARleKVADE-KWNEDATTEDE 524
Cdd:PTZ00121 1499 ADEAKkaAEAKKKADEAKKAEEA--KKADEaKKAEEAKKADE 1538
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
250-542 2.08e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.84  E-value: 2.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 250 ELDRLRDTVKALTREQE---KLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQ---------RL 317
Cdd:COG4717   72 ELKELEEELKEAEEKEEeyaELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAElaelperleEL 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 318 KDKVAQMKDTLGQAQQRVAELEPLKEQL-RGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAE 396
Cdd:COG4717  152 EERLEELRELEEELEELEAELAELQEELeELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQ 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 397 L--GLHLKEEKCQWSKER-----AGLLQSVEAEKDKILKLSAEILRLEKAVQE----ERTQNQVFKTELAREKDSSLVQL 465
Cdd:COG4717  232 LenELEAAALEERLKEARlllliAAALLALLGLGGSLLSLILTIAGVLFLVLGllalLFLLLAREKASLGKEAEELQALP 311
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767974945 466 SESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVadEKWNEDATTEDEEAAVGLSCPAALTDSEDE 542
Cdd:COG4717  312 ALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA--EELEEELQLEELEQEIAALLAEAGVEDEEE 386
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
155-514 2.22e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 47.81  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  155 ESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQ----EHTELMEQYKGISRSHGEITEERDILSRQqgdhVARI 230
Cdd:pfam05557   3 ELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRqldrESDRNQELQKRIRLLEKREAEAEEALREQ----AELN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  231 LELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQ 310
Cdd:pfam05557  79 RLKKKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  311 SAQAQRLKDKVAQMKD----------------TLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD 374
Cdd:pfam05557 159 EKQQSSLAEAEQRIKElefeiqsqeqdseivkNSKSELARIPELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKLE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  375 RtiaeLHRSRLEVAEVNGRLAELGLHLKEekcqWSKeragLLQSVEAEKDKILKLSAEILRLEkavQEERTqnqvfkteL 454
Cdd:pfam05557 239 R----EEKYREEAATLELEKEKLEQELQS----WVK----LAQDTGLNLRSPEDLSRRIEQLQ---QREIV--------L 295
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  455 AREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK 514
Cdd:pfam05557 296 KEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKER 355
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
151-382 2.46e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.73  E-value: 2.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 151 NQLDESQQERNDLMQLKLQ-LEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILsrqqgdhvar 229
Cdd:PRK02224 522 EELIAERRETIEEKRERAEeLRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESL---------- 591
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 230 ileleDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENhhLNLDLKEAKSWQEE 309
Cdd:PRK02224 592 -----ERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEE--AREDKERAEEYLEQ 664
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 310 QSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLrgaQELAASSQQKATLLGE--ELASA-----AAARDRTIAELHR 382
Cdd:PRK02224 665 VEEKLDELREERDDLQAEIGAVENELEELEELRERR---EALENRVEALEALYDEaeELESMygdlrAELRQRNVETLER 741
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
315-507 2.50e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.07  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 315 QRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRgaqelaassqqkatllgEELASAAAARDRTIAELHRSRLEVAEVNGRL 394
Cdd:COG1579   13 QELDSELDRLEHRLKELPAELAELEDELAALE-----------------ARLEAAKTELEDLEKEIKRLELEIEEVEARI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 395 AELGLHLKEEKCQwsKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDsslvqlsESKRELTE 474
Cdd:COG1579   76 KKYEEQLGNVRNN--KEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEA-------ELEEKKAE 146
                        170       180       190
                 ....*....|....*....|....*....|...
gi 767974945 475 LRSALRVLQKEKEQLQEEKQELLEymrKLEARL 507
Cdd:COG1579  147 LDEELAELEAELEELEAEREELAA---KIPPEL 176
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
232-526 2.50e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.83  E-value: 2.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 232 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAdkeqseaELQVAQQENHHLNLDLKEAKSWQEEQS 311
Cdd:COG1340   12 ELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELRE-------EAQELREKRDELNEKVKELKEERDELN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 312 AQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQElaasSQQKATLLGEElasaaaarDRTIAElhrsrlevaevn 391
Cdd:COG1340   85 EKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEW----RQQTEVLSPEE--------EKELVE------------ 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 392 gRLAELglhlkeekcqwsKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQnqvfKTELAREKDSSLVQLSESKRE 471
Cdd:COG1340  141 -KIKEL------------EKELEKAKKALEKNEKLKELRAELKELRKEAEEIHKK----IKELAEEAQELHEEMIELYKE 203
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767974945 472 LTELRSALRVLQKEKEQLQEE-----------KQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
Cdd:COG1340  204 ADELRKEADELHKEIVEAQEKadelheeiielQKELRELRKELKKLRKKQRALKREKEKEELEEKA 269
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
151-502 4.04e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 46.06  E-value: 4.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 151 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDilsrqqgdhvari 230
Cdd:COG1340    1 SKTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRD------------- 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 231 lELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLL---GQLKEVQADKEQSEAELQVAqqenhhlNLDLKEAKswq 307
Cdd:COG1340   68 -ELNEKVKELKEERDELNEKLNELREELDELRKELAELNkagGSIDKLRKEIERLEWRQQTE-------VLSPEEEK--- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 308 eeqsaqaqRLKDKVAQMKdtlgqaqqrvAELEPLKEQLRGAQELaassqqkatllgeelasaaaarDRTIAELHRSRLEV 387
Cdd:COG1340  137 --------ELVEKIKELE----------KELEKAKKALEKNEKL----------------------KELRAELKELRKEA 176
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 388 AEVNGRLAELGlhlkEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQnqvfktelAREKDSSLVQLSE 467
Cdd:COG1340  177 EEIHKKIKELA----EEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEE--------IIELQKELRELRK 244
                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 767974945 468 skrELTELRSALRVLQKEKEQ--LQEEKQELLEYMRK 502
Cdd:COG1340  245 ---ELKKLRKKQRALKREKEKeeLEEKAEEIFEKLKK 278
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
149-288 4.10e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.93  E-value: 4.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQ----------------VTELRSRVQELERALATARQEHTE-------LMEQYKG- 204
Cdd:COG3206  224 LESQLAEARAELAEAEARLAALRAQlgsgpdalpellqspvIQQLRAQLAELEAELAELSARYTPnhpdviaLRAQIAAl 303
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 205 -------ISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKvltkEVELDRLRDTVKALTREQEKLLGQLKEVQA 277
Cdd:COG3206  304 raqlqqeAQRILASLEAELEALQAREASLQAQLAQLEARLAELPEL----EAELRRLEREVEVARELYESLLQRLEEARL 379
                        170
                 ....*....|.
gi 767974945 278 DKEQSEAELQV 288
Cdd:COG3206  380 AEALTVGNVRV 390
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
231-526 4.25e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.43  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 231 LELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQEnhhlnldLKEAKSWQEEQ 310
Cdd:COG4372   13 LSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSE-------LEQLEEELEEL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 311 SAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRS----RLE 386
Cdd:COG4372   86 NEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQleslQEE 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 387 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLS 466
Cdd:COG4372  166 LAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELE 245
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767974945 467 ESKRELTELRSALRVLQKEKE--QLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
Cdd:COG4372  246 EDKEELLEEVILKEIEELELAilVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAAL 307
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
250-397 4.65e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 250 ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKswqeeqsAQAQRLKDKVAQMKDT-- 327
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE-------ARIKKYEEQLGNVRNNke 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 328 -------LGQAQQRVAELE----PLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRsrlEVAEVNGRLAE 396
Cdd:COG1579   91 yealqkeIESLKRRISDLEdeilELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEA---ELEELEAEREE 167

                 .
gi 767974945 397 L 397
Cdd:COG1579  168 L 168
PTZ00121 PTZ00121
MAEBL; Provisional
117-548 4.75e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 4.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  117 QFREPRPMDELVTLEEADGGSDillVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHT 196
Cdd:PTZ00121 1219 KAEDAKKAEAVKKAEEAKKDAE---EAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEA 1295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  197 ELMEQYKGISRSHGEITEER--DILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKAltREQEKLLGQLKE 274
Cdd:PTZ00121 1296 KKAEEKKKADEAKKKAEEAKkaDEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEA--AEEKAEAAEKKK 1373
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  275 VQADKEQSEAELQVAQQENhhlnldLKEAKSWQEEQSAQAQRLKDKVAQMK--DTLGQAQQRVAELEPLK---EQLRGAQ 349
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEEKKK------ADEAKKKAEEDKKKADELKKAAAAKKkaDEAKKKAEEKKKADEAKkkaEEAKKAD 1447
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  350 ELAASSQQK-----ATLLGEELASAAAARDRtiAELHRSRLEV---AEVNGRLAELGLHLKEEKcqwsKERAGLLQSVEA 421
Cdd:PTZ00121 1448 EAKKKAEEAkkaeeAKKKAEEAKKADEAKKK--AEEAKKADEAkkkAEEAKKKADEAKKAAEAK----KKADEAKKAEEA 1521
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  422 EKDKILKLSAEILRLEKA--VQEERTQNQVFKTE---LAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQEL 496
Cdd:PTZ00121 1522 KKADEAKKAEEAKKADEAkkAEEKKKADELKKAEelkKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLY 1601
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767974945  497 LEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMR 548
Cdd:PTZ00121 1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELK 1653
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
145-529 5.20e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.89  E-value: 5.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   145 KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHT-ELMEQYKGISRSHGEITEERDI----- 218
Cdd:TIGR00618  404 ILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKlEKIHLQESAQSLKEREQQLQTKeqihl 483
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   219 -LSRQQGDHVARILELEDDIQTISEKVLTKEVE-------------LDRLRDTVKALTREQEKLLGQL----KEVQADKE 280
Cdd:TIGR00618  484 qETRKKAVVLARLLELQEEPCPLCGSCIHPNPArqdidnpgpltrrMQRGEQTYAQLETSEEDVYHQLtserKQRASLKE 563
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   281 QSEAELQ----VAQQEN-----------------HHLNLDLKEAKSWQEEQSAQAQRLKDKVA--QMKDTLGQAQQRVAE 337
Cdd:TIGR00618  564 QMQEIQQsfsiLTQCDNrskedipnlqnitvrlqDLTEKLSEAEDMLACEQHALLRKLQPEQDlqDVRLHLQQCSQELAL 643
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   338 LEPLKEQL-------RGAQELAASSQQKATLLGEELASAAAARDRtIAELHRSRLEVAEVNGRLAELGLHLKE---EKCQ 407
Cdd:TIGR00618  644 KLTALHALqltltqeRVREHALSIRVLPKELLASRQLALQKMQSE-KEQLTYWKEMLAQCQTLLRELETHIEEydrEFNE 722
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   408 WSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKE 487
Cdd:TIGR00618  723 IENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLK 802
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 767974945   488 QLQEE-KQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVG 529
Cdd:TIGR00618  803 TLEAEiGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLG 845
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
149-511 5.33e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 46.66  E-value: 5.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQ---GD 225
Cdd:pfam05557  88 LNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQsslAE 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  226 HVARILELEDDIQT-ISEKVLTK------------EVELDRLRDTVKALTR--------------------EQEKLLGQL 272
Cdd:pfam05557 168 AEQRIKELEFEIQSqEQDSEIVKnskselaripelEKELERLREHNKHLNEnienklllkeevedlkrkleREEKYREEA 247
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  273 KEVQADKEQSEAELQ--VAQQENHHLNLDLKEAKSWQ------------EEQSAQAQRLKDKVAQMKDTLGQAQQRVAEL 338
Cdd:pfam05557 248 ATLELEKEKLEQELQswVKLAQDTGLNLRSPEDLSRRieqlqqreivlkEENSSLTSSARQLEKARRELEQELAQYLKKI 327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  339 EPLKEQLRGAQELAASSQQKATLLGEE----------------LASAAAARDRTIAELH-------------RSRLEVAE 389
Cdd:pfam05557 328 EDLNKKLKRHKALVRRLQRRVLLLTKErdgyrailesydkeltMSNYSPQLLERIEEAEdmtqkmqahneemEAQLSVAE 407
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  390 VNGRLAELGLHLKEEKCQWSKERAGLL-QSVEAEKDKILKLSAEILRLEkaVQEERTQNQVFKTELARE--------KDS 460
Cdd:pfam05557 408 EELGGYKQQAQTLERELQALRQQESLAdPSYSKEEVDSLRRKLETLELE--RQRLREQKNELEMELERRclqgdydpKKT 485
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767974945  461 SLVQLSESKRELtelrsALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVA 511
Cdd:pfam05557 486 KVLHLSMNPAAE-----AYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVL 531
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
213-527 5.36e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.49  E-value: 5.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 213 TEERDILSRQQGDHVARILELEDDIQTI---SEKVLTKEVELDRlRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVA 289
Cdd:COG5185  241 PESELEDLAQTSDKLEKLVEQNTDLRLEklgENAESSKRLNENA-NNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLA 319
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 290 QQEnhhLNLDLKEAKSwqeEQSAQAQRLKDKVAQMKDTLgqaQQRVAELEPLKEQLRGAQELAASSqqkatllgEELASA 369
Cdd:COG5185  320 AAE---AEQELEESKR---ETETGIQNLTAEIEQGQESL---TENLEAIKEEIENIVGEVELSKSS--------EELDSF 382
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 370 AAARDRTIAELHRSRLEVAEVNGRLAE-----LGLHLKEEKcQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEER 444
Cdd:COG5185  383 KDTIESTKESLDEIPQNQRGYAQEILAtledtLKAADRQIE-ELQRQIEQATSSNEEVSKLLNELISELNKVMREADEES 461
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 445 TQNQVfktelarekdsslvqlSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEK---VADEKWNEDATT 521
Cdd:COG5185  462 QSRLE----------------EAYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERqleGVRSKLDQVAES 525

                 ....*.
gi 767974945 522 EDEEAA 527
Cdd:COG5185  526 LKDFMR 531
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
242-506 5.39e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.60  E-value: 5.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 242 EKVLTKEVELDRLRdtvkaltREQEKLLGQLKEVQADKEQSEAELQvaQQENhhLNLDLKEAKSWQEEQSAQAQRLKDKV 321
Cdd:PRK03918 148 EKVVRQILGLDDYE-------NAYKNLGEVIKEIKRRIERLEKFIK--RTEN--IEELIKEKEKELEEVLREINEISSEL 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 322 AQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGE---ELASAAAARDRTIAELHRSRLEVAEVNG------ 392
Cdd:PRK03918 217 PELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEkirELEERIEELKKEIEELEEKVKELKELKEkaeeyi 296
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 393 RLAELGLHLKEEKCQWSKERAGL---LQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT-----ELAREKDSSLVQ 464
Cdd:PRK03918 297 KLSEFYEEYLDELREIEKRLSRLeeeINGIEERIKELEEKEERLEELKKKLKELEKRLEELEErhelyEEAKAKKEELER 376
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 767974945 465 LSESKRELT--ELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
Cdd:PRK03918 377 LKKRLTGLTpeKLEKELEELEKAKEEIEEEISKITARIGELKKE 420
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
180-527 6.30e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 46.32  E-value: 6.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   180 RVQELERALATARQEHTELMEqykgISRSHGEITEERDILSRQQgdhvaRILELEDDiQTISEKvltkevelDRLRDTVK 259
Cdd:pfam01576  620 YAEERDRAEAEAREKETRALS----LARALEEALEAKEELERTN-----KQLRAEME-DLVSSK--------DDVGKNVH 681
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   260 ALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSwQEEQSAQAqrlKDKVAQMKDTlgQAQQRVAELE 339
Cdd:pfam01576  682 ELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKA-QFERDLQA---RDEQGEEKRR--QLVKQVRELE 755
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   340 PLKEQLRGAQELAASSQQKATLLGEELAS----AAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEkcqwskeragL 415
Cdd:pfam01576  756 AELEDERKQRAQAVAAKKKLELDLKELEAqidaANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEI----------L 825
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   416 LQSVEAEKdKILKLSAEILRLEK---AVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEE 492
Cdd:pfam01576  826 AQSKESEK-KLKNLEAELLQLQEdlaASERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSN 904
                          330       340       350
                   ....*....|....*....|....*....|....*
gi 767974945   493 KQELLEYMRKLEARLEKVADEKWNEDATTEDEEAA 527
Cdd:pfam01576  905 TELLNDRLRKSTLQVEQLTTELAAERSTSQKSESA 939
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
309-596 6.58e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 6.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 309 EQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELhRSRLEVA 388
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL-GERARAL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 389 EVNGRLAELGLHLKEekcqwSKERAGLLQSVEAeKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSES 468
Cdd:COG3883   96 YRSGGSVSYLDVLLG-----SESFSDFLDRLSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAA 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 469 KRELTELRSALRVLQKE-KEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDM 547
Cdd:COG3883  170 KAELEAQQAEQEALLAQlSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGA 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 767974945 548 RLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSD 596
Cdd:COG3883  250 GAAGAAGAAAGSAGAAGAAAGAAGAGAAAASAAGGGAGGAGGGGGGGGA 298
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
103-496 6.72e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.50  E-value: 6.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   103 VNRQGQVCGQSPPFQFREPRPMDElVTLEEADGGSDILLVVPKATVLQNQLDESQQerndLMQLKLQLEGQVTELRSRVQ 182
Cdd:TIGR00618  485 ETRKKAVVLARLLELQEEPCPLCG-SCIHPNPARQDIDNPGPLTRRMQRGEQTYAQ----LETSEEDVYHQLTSERKQRA 559
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   183 ELERALATARQEHTELMEQYKGISRSHGEITEERDILsRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALT 262
Cdd:TIGR00618  560 SLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRL-QDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCS 638
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   263 REQEKLLgqlkevqADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSA--QAQRLKDKVAQMKDTLGQAQQRVAELEP 340
Cdd:TIGR00618  639 QELALKL-------TALHALQLTLTQERVREHALSIRVLPKELLASRQLAlqKMQSEKEQLTYWKEMLAQCQTLLRELET 711
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   341 -LKEQLRGAQELA-ASSQQKATLLGEELASA-----------AAARDRTIAELHRSRLEVAEVNgRLAELGlHLKEEKCQ 407
Cdd:TIGR00618  712 hIEEYDREFNEIEnASSSLGSDLAAREDALNqslkelmhqarTVLKARTEAHFNNNEEVTAALQ-TGAELS-HLAAEIQF 789
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   408 WSKERA---GLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNqvFKTELaREKDSSLVQLSESKRELTELRSALRVLQK 484
Cdd:TIGR00618  790 FNRLREedtHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQ--FLSRL-EEKSATLGEITHQLLKYEECSKQLAQLTQ 866
                          410
                   ....*....|..
gi 767974945   485 EKEQLQEEKQEL 496
Cdd:TIGR00618  867 EQAKIIQLSDKL 878
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
226-508 8.23e-05

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 45.95  E-value: 8.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  226 HVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLgqlkevqadkeqseAELQVAQQENHHLnldlkeakS 305
Cdd:PRK10246  193 HKSARTELEKLQAQASGVALLTPEQVQSLTASLQVLTDEEKQLL--------------TAQQQQQQSLNWL--------T 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  306 WQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLK--EQLRGA----QELAAS---SQQKATLLGEELASAAAARDRT 376
Cdd:PRK10246  251 RLDELQQEASRRQQALQQALAAEEKAQPQLAALSLAQpaRQLRPHweriQEQSAAlahTRQQIEEVNTRLQSTMALRARI 330
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  377 IAELHRSRLEVAEVNGRLAELgLHLKEEKCQWSKERAG---LLQSVEAEKDKILKLSAeilRLEKAVQEERTQNQVFKTE 453
Cdd:PRK10246  331 RHHAAKQSAELQAQQQSLNTW-LAEHDRFRQWNNELAGwraQFSQQTSDREQLRQWQQ---QLTHAEQKLNALPAITLTL 406
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767974945  454 LAREKDSSLVQLSES---KRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE 508
Cdd:PRK10246  407 TADEVAAALAQHAEQrplRQRLVALHGQIVPQQKRLAQLQVAIQNVTQEQTQRNAALN 464
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
141-593 8.77e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.88  E-value: 8.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   141 LVVPKATvLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELEralatarQEHTELMEQYKGISRSHGEITEERDILs 220
Cdd:pfam15921  588 MQVEKAQ-LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLE-------LEKVKLVNAGSERLRAVKDIKQERDQL- 658
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   221 rqqgdhVARILELEDDIQTISEKVltkEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLnldL 300
Cdd:pfam15921  659 ------LNEVKTSRNELNSLSEDY---EVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHA---M 726
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   301 KEAKSWQEEQSAQAqrlkdkvaqmkdtlGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAEL 380
Cdd:pfam15921  727 KVAMGMQKQITAKR--------------GQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGEL 792
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   381 HRSRLEVAEVNGRLAELGLHLKEEKCQWSkERAGLLQSVEAEKDKiLKL-----------------SAEILRLEKAVQEE 443
Cdd:pfam15921  793 EVLRSQERRLKEKVANMEVALDKASLQFA-ECQDIIQRQEQESVR-LKLqhtldvkelqgpgytsnSSMKPRLLQPASFT 870
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   444 RTQNQVFKTE-----LAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNED 518
Cdd:pfam15921  871 RTHSNVPSSQstasfLSHHSRKTNALKEDPTRDLKQLLQELRSVINEEPTVQLSKAEDKGRAPSLGALDDRVRDCIIESS 950
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   519 ATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPyglCERGDPGSSPAGPREASPLVVIS---------QPAPISPHLSGP 589
Cdd:pfam15921  951 LRSDICHSSSNSLQTEGSKSSETCSREPVLLHA---GELEDPSSCFTFPSTASPSVKNSasrsfhsspKKSPVHSLLTSS 1027

                   ....
gi 767974945   590 AEDS 593
Cdd:pfam15921 1028 AEGS 1031
PRK01156 PRK01156
chromosome segregation protein; Provisional
145-507 9.74e-05

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 45.66  E-value: 9.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 145 KATVLQ---NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILsr 221
Cdd:PRK01156 330 KLSVLQkdyNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAI-- 407
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 222 qqgdhVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQ------------------LKEVQADKEQSE 283
Cdd:PRK01156 408 -----KKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpvcgttlgeeksnhiINHYNEKKSRLE 482
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 284 AELQVAQQENHHLNLDLKEAKSWQEE-QSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELaaSSQQKATLL 362
Cdd:PRK01156 483 EKIREIEIEVKDIDEKIVDLKKRKEYlESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEI--KNRYKSLKL 560
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 363 G------EELASAAAARDRTIAELHRSRLEvaEVNGRL--AELGLH--------LKEEKCQWSKERAGLLQSVEAEKDKI 426
Cdd:PRK01156 561 EdldskrTSWLNALAVISLIDIETNRSRSN--EIKKQLndLESRLQeieigfpdDKSYIDKSIREIENEANNLNNKYNEI 638
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 427 LKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSlVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEAR 506
Cdd:PRK01156 639 QENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEIT-SRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDR 717

                 .
gi 767974945 507 L 507
Cdd:PRK01156 718 I 718
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
171-492 9.80e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.10  E-value: 9.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  171 EGQVTELRSRVQELERALATARQEHTELMEQYKgisrshgEITEERDILSRQQG--------DHVARILELEDDIQTISE 242
Cdd:COG3096   835 EAELAALRQRRSELERELAQHRAQEQQLRQQLD-------QLKEQLQLLNKLLPqanlladeTLADRLEELREELDAAQE 907
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  243 K---VLTKEVELDRLRDTVKALTREQEkllgQLKEVQADKEQSEAELQVAQQENHHLN--LDLKEAKSWQEeqsaqAQRL 317
Cdd:COG3096   908 AqafIQQHGKALAQLEPLVAVLQSDPE----QFEQLQADYLQAKEQQRRLKQQIFALSevVQRRPHFSYED-----AVGL 978
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  318 KDKVAQMKDTLgQAQQRVAELEPLK--EQLRGAQELAASSQQKATllgeELASAAAARDRTIAELHRsrlevaevngRLA 395
Cdd:COG3096   979 LGENSDLNEKL-RARLEQAEEARREarEQLRQAQAQYSQYNQVLA----SLKSSRDAKQQTLQELEQ----------ELE 1043
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  396 ELGLHLKEEkcqwSKERAgllqsvEAEKDKIlklsaeilrlekavQEERTQNQVFKTELarEKdsslvQLSESKRELTEL 475
Cdd:COG3096  1044 ELGVQADAE----AEERA------RIRRDEL--------------HEELSQNRSRRSQL--EK-----QLTRCEAEMDSL 1092
                         330
                  ....*....|....*..
gi 767974945  476 RSALRVLQKEKEQLQEE 492
Cdd:COG3096  1093 QKRLRKAERDYKQEREQ 1109
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
276-388 1.09e-04

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 45.11  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  276 QADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAAS- 354
Cdd:pfam00529  57 QAALDSAEAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIg 136
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767974945  355 --SQQKATLLGEELASAAAARDRTIAELHRSRLEVA 388
Cdd:pfam00529 137 giSRESLVTAGALVAQAQANLLATVAQLDQIYVQIT 172
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
232-513 1.24e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 1.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   232 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEK-------------------------LLGQLKEVQADKEQSEAEL 286
Cdd:pfam02463  181 ETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKekleleeeyllyldylklneeridlLQELLRDEQEEIESSKQEI 260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   287 QVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVA----ELEPLKEQLRGAQELAASSQQKATLL 362
Cdd:pfam02463  261 EKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVddeeKLKESEKEKKKAEKELKKEKEEIEEL 340
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   363 GEELASAAAAR--DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILR-LEKA 439
Cdd:pfam02463  341 EKELKELEIKReaEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARqLEDL 420
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767974945   440 VQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQ---LQEEKQELLEYMRKLEARLEKVADE 513
Cdd:pfam02463  421 LKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKsedLLKETQLVKLQEQLELLLSRQKLEE 497
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
234-448 1.47e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 234 EDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQ 313
Cdd:COG3883   15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 314 AQR--------------------------LKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELA 367
Cdd:COG3883   95 LYRsggsvsyldvllgsesfsdfldrlsaLSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELE 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 368 SAAAARDRTIAELhrsRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQN 447
Cdd:COG3883  175 AQQAEQEALLAQL---SAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGA 251

                 .
gi 767974945 448 Q 448
Cdd:COG3883  252 A 252
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
248-495 1.52e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 248 EVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAkswQEEQSAQAQRLKDKVAQMKDT 327
Cdd:COG3883   15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKL---QAEIAEAEAEIEERREELGER 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 328 LGQAQQRVAELEPLkEQLRGAQELAassqqkatllgeELASAAAARDRtIAELHRSRLEvaEVNGRLAElglhLKEEKcq 407
Cdd:COG3883   92 ARALYRSGGSVSYL-DVLLGSESFS------------DFLDRLSALSK-IADADADLLE--ELKADKAE----LEAKK-- 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 408 wskeragllQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKE 487
Cdd:COG3883  150 ---------AELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220

                 ....*...
gi 767974945 488 QLQEEKQE 495
Cdd:COG3883  221 AAAAAAAA 228
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
176-399 1.93e-04

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 44.68  E-value: 1.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 176 ELRSRVQELERALATARQEHTELMEQYKGISR---SHGE---ITEERDILSrqqgdHVARILEledDIQTISEkvLTKEV 249
Cdd:COG0497  169 ALKKELEELRADEAERARELDLLRFQLEELEAaalQPGEeeeLEEERRRLS-----NAEKLRE---ALQEALE--ALSGG 238
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 250 E---LDRLRDTVKALtREQEKLLGQLKEVQADKEQSEAELQVAQQE-NHHL-NLDLKEAK-SWQEEQSAQAQRLKDK--- 320
Cdd:COG0497  239 EggaLDLLGQALRAL-ERLAEYDPSLAELAERLESALIELEEAASElRRYLdSLEFDPERlEEVEERLALLRRLARKygv 317
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 321 -VAQMKDTLGQAQQRVAELEplkeqlRGAQELAAssqqkatlLGEELASAAAARDRTIAELHRSRLEVA-----EVNGRL 394
Cdd:COG0497  318 tVEELLAYAEELRAELAELE------NSDERLEE--------LEAELAEAEAELLEAAEKLSAARKKAAkklekAVTAEL 383

                 ....*
gi 767974945 395 AELGL 399
Cdd:COG0497  384 ADLGM 388
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
149-495 2.07e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 44.71  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  149 LQNQLDESQQERNDLMQLKLQ----LEGQVTELRS-------RVQELERALATARQEHTELMEQYKGISRSHGEITEE-- 215
Cdd:pfam05483 430 IAEELKGKEQELIFLLQAREKeihdLEIQLTAIKTseehylkEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEas 509
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  216 ----------RDILS--RQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKA-LTREQEKLLGQLKEVQADKEQS 282
Cdd:pfam05483 510 dmtlelkkhqEDIINckKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCkLDKSEENARSIEYEVLKKEKQM 589
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  283 EAELQVA-----QQENHHLNLD--LKEAKSWQEEQSAQAQRL---KDKVAQMKDTLGQAQQRVAELeplkeqlrgaqela 352
Cdd:pfam05483 590 KILENKCnnlkkQIENKNKNIEelHQENKALKKKGSAENKQLnayEIKVNKLELELASAKQKFEEI-------------- 655
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  353 ASSQQKatllgeELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLhlkeeKCQWS-KERAGLLQSVEAEKDKILKLSA 431
Cdd:pfam05483 656 IDNYQK------EIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDK-----RCQHKiAEMVALMEKHKHQYDKIIEERD 724
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974945  432 EILRLEKAVQEERTQNQVfktelarekdSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQE 495
Cdd:pfam05483 725 SELGLYKNKEQEQSSAKA----------ALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKE 778
PRK09039 PRK09039
peptidoglycan -binding protein;
241-397 2.09e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 44.19  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 241 SEKVLTKEVELDRLRDTVKALTReqekLLG----QLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQR 316
Cdd:PRK09039  45 SREISGKDSALDRLNSQIAELAD----LLSlerqGNQDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAEGRAGE 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 317 LKDKVAQMKDTLGQAQQRVAEL----EPLKEQLRGAQEL-------AASSQQKATLLGEELASAAAARdrtIAELHRSRl 385
Cdd:PRK09039 121 LAQELDSEKQVSARALAQVELLnqqiAALRRQLAALEAAldasekrDRESQAKIADLGRRLNVALAQR---VQELNRYR- 196
                        170
                 ....*....|..
gi 767974945 386 evAEVNGRLAEL 397
Cdd:PRK09039 197 --SEFFGRLREI 206
PRK11637 PRK11637
AmiB activator; Provisional
271-527 2.20e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 44.30  E-value: 2.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 271 QLKEVQADKEQSEAELQVAQQENHHLNLDLKEakswQEEQSAQAQRlkdKVAQMKDTLGQAQQRVAELEPLKEQLRGAQe 350
Cdd:PRK11637  48 QLKSIQQDIAAKEKSVRQQQQQRASLLAQLKK----QEEAISQASR---KLRETQNTLNQLNKQIDELNASIAKLEQQQ- 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 351 laaSSQQKatLLGEELAsaAAARdrtiaelhrsrlevaevNGRLAELGLHLKEEKCQWSkERA----GLLQsvEAEKDKI 426
Cdd:PRK11637 120 ---AAQER--LLAAQLD--AAFR-----------------QGEHTGLQLILSGEESQRG-ERIlayfGYLN--QARQETI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 427 --LKLSAEILRLEKAVQEE-RTQNQVFKTELAREKDSSLVQLSESKRELTELRSAlrvLQKEKEQLQEekqelleyMRKL 503
Cdd:PRK11637 173 aeLKQTREELAAQKAELEEkQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESS---LQKDQQQLSE--------LRAN 241
                        250       260
                 ....*....|....*....|....*..
gi 767974945 504 EARL-EKVADEKWNEDATTEDE--EAA 527
Cdd:PRK11637 242 ESRLrDSIARAEREAKARAEREarEAA 268
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
149-515 2.25e-04

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 44.29  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  149 LQNQLDESQQE-------RNDLMQLKLQLEGQVTELRSRVQELERALATARQehtelmeqykgisrshgeITEERDILsR 221
Cdd:pfam05622  64 LQKQLEQLQEEnfrletaRDDYRIKCEELEKEVLELQHRNEELTSLAEEAQA------------------LKDEMDIL-R 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  222 QQGDHVARileLEDDIQTISEKVltkeVELDRLRDTVKAL----------TREQEKllgQLKEVQADKEQSEAELQVAQQ 291
Cdd:pfam05622 125 ESSDKVKK---LEATVETYKKKL----EDLGDLRRQVKLLeernaeymqrTLQLEE---ELKKANALRGQLETYKRQVQE 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  292 ENHHLNLDLKEAKSWQ------EEQSAQAQRLKDKVAQMKDTL---------GQAQQRvaeleplkeQLRGAQELAASSQ 356
Cdd:pfam05622 195 LHGKLSEESKKADKLEfeykklEEKLEALQKEKERLIIERDTLretneelrcAQLQQA---------ELSQADALLSPSS 265
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  357 QKATLLGEELASaAAARDRTIAELHRSRL----EVAEVNGRLAELGLHLkeEKCQWSKERagLLQSVEAEKDKILKLSAE 432
Cdd:pfam05622 266 DPGDNLAAEIMP-AEIREKLIRLQHENKMlrlgQEGSYRERLTELQQLL--EDANRRKNE--LETQNRLANQRILELQQQ 340
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  433 ILRLEKAVQEERTQNQVFKTeLAREKDSSLVQLSESKRELTELRSALRVLQ-KEKEQLQEEKQELLEYMRKLEARLeKVA 511
Cdd:pfam05622 341 VEELQKALQEQGSKAEDSSL-LKQKLEEHLEKLHEAQSELQKKKEQIEELEpKQDSNLAQKIDELQEALRKKDEDM-KAM 418

                  ....
gi 767974945  512 DEKW 515
Cdd:pfam05622 419 EERY 422
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
149-278 2.66e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.52  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  149 LQNQLDESQQERNDLMQLKLQLEgqvtELRSRVQELERALATARQEHTELMEQYKGISRshgEITEERDILSR-QQGDHV 227
Cdd:COG4913   673 LEAELERLDASSDDLAALEEQLE----ELEAELEELEEELDELKGEIGRLEKELEQAEE---ELDELQDRLEAaEDLARL 745
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767974945  228 ARILELEDDIQTISEKVLTKEVElDRLRDTVKALTREQEKLLGQLKEVQAD 278
Cdd:COG4913   746 ELRALLEERFAAALGDAVERELR-ENLEERIDALRARLNRAEEELERAMRA 795
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
215-355 2.87e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 215 ERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTRE-------QEKLLGQLKEVQADKEQS--EAE 285
Cdd:COG1579   18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEieevearIKKYEEQLGNVRNNKEYEalQKE 97
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767974945 286 LQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQR----VAELEPLKEQLRGAQELAASS 355
Cdd:COG1579   98 IESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAEldeeLAELEAELEELEAEREELAAK 171
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
230-347 3.43e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.47  E-value: 3.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   230 ILELEDDIQTISEKVLTKEVEL-----DRLRDTVKALTREqeklLGQLKEVQADKEQ-SEAELQVAQQENHHLNLDLKEA 303
Cdd:smart00787 148 GLDENLEGLKEDYKLLMKELELlnsikPKLRDRKDALEEE----LRQLKQLEDELEDcDPTELDRAKEKLKKLLQEIMIK 223
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 767974945   304 KSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRG 347
Cdd:smart00787 224 VKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
CCDC73 pfam15818
Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil ...
246-524 3.69e-04

Coiled-coil domain-containing protein 73 family; CCDC73 is a family of eukaryotic coiled-coil containing proteins. The function is not known. The alternative name is sarcoma antigen NY-SAR-79.


Pssm-ID: 464893 [Multi-domain]  Cd Length: 1048  Bit Score: 44.17  E-value: 3.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   246 TKEVELDRLRDTVKALTREQEKLLGQLKEVqadkEQsEAELQVAQQENHHLNLD---------------LKEAKSWQEEQ 310
Cdd:pfam15818   89 IKEKEIEGLKETLKALQVSKYSLQKKVSEM----EQ-KLQLHLLAKEDHHKQLNeiekyyatitgqfglVKENHGKLEQN 163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   311 SAQAQRLKDKVAqmkdTLGQAQQrvAELEPLKEQLRG-AQELAASSQQKATLLGEELASaAAARDRTIAELH-RSRLEVa 388
Cdd:pfam15818  164 VQEAIQLNKRLS----ALNKKQE--SEICSLKKELKKvTSDLIKSKVTCQYKMGEENIN-LTIKEQKFQELQeRLNMEL- 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   389 EVNGRLAELGLHLKEEKcqwsKERAGLLQSVEAEKDKILKLSAEIlRLEKAVQEERTQNQVFKTELAREKdsslvqLSES 468
Cdd:pfam15818  236 ELNKKINEEITHIQEEK----QDIIISFQHMQQLLQQQTQANTEM-EAELKALKENNQTLERDNELQREK------VKEN 304
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767974945   469 KRELTELRS----ALRVLQKEKEQLQEEKQEL---LEYMRKLEARLEKVADEKWNEDATTEDE 524
Cdd:pfam15818  305 EEKFLNLQNehekALGTWKKHVEELNGEINEIkneLSSLKETHIKLQEHYNKLCNQKKFEEDK 367
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
162-309 4.20e-04

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 43.08  E-value: 4.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   162 DLMQLKLQLEGQVTELRSR--------------VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQqgdhV 227
Cdd:smart00787 113 LLMDKQFQLVKTFARLEAKkmwyewrmklleglKEGLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEE----L 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   228 ARILELEDDIQTIsekvltKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ 307
Cdd:smart00787 189 RQLKQLEDELEDC------DPTELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKL 262

                   ..
gi 767974945   308 EE 309
Cdd:smart00787 263 EQ 264
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
117-505 4.80e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.79  E-value: 4.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  117 QFREPRPMDELVTLEEADGG--------SDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERAL 188
Cdd:COG3096   305 QYRLVEMARELEELSARESDleqdyqaaSDHLNLVQTALRQQEKIERYQEDLEELTERLEEQEEVVEEAAEQLAEAEARL 384
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  189 ATARQEHTELMEQ-----------------YKGISRSHGE---ITEERDILSRQQGDHVArilELEDDIQTISEKVLTKE 248
Cdd:COG3096   385 EAAEEEVDSLKSQladyqqaldvqqtraiqYQQAVQALEKaraLCGLPDLTPENAEDYLA---AFRAKEQQATEEVLELE 461
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  249 velDRLRDTvKALTREQEKLLGQLKEVQADKEQSEAeLQVAQQEnhhlnldLKEAKswqeEQSAQAQRlkdkVAQMKDTL 328
Cdd:COG3096   462 ---QKLSVA-DAARRQFEKAYELVCKIAGEVERSQA-WQTAREL-------LRRYR----SQQALAQR----LQQLRAQL 521
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  329 GQAQQRVaeleplkEQLRGAQELAASSQQKAtllGEELASAAAardrtiAELHRSRLEVaevngRLAELGLHLKEEkcqw 408
Cdd:COG3096   522 AELEQRL-------RQQQNAERLLEEFCQRI---GQQLDAAEE------LEELLAELEA-----QLEELEEQAAEA---- 576
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  409 SKERAGLLQSVEAEKDKILKLSAEILRLEKAvQEERTQnqvfkteLAREKDSSLvqlsESKRELTELRSAL----RVLQK 484
Cdd:COG3096   577 VEQRSELRQQLEQLRARIKELAARAPAWLAA-QDALER-------LREQSGEAL----ADSQEVTAAMQQLlereREATV 644
                         410       420
                  ....*....|....*....|.
gi 767974945  485 EKEQLQEEKQELLEYMRKLEA 505
Cdd:COG3096   645 ERDELAARKQALESQIERLSQ 665
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
174-514 5.89e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.50  E-value: 5.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   174 VTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDhvarILELEDDIQTIsEKVLTKEVELDR 253
Cdd:TIGR00606  195 RQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENE----LDPLKNRLKEI-EHNLSKIMKLDN 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   254 LRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQ-----EEQSAQAQRLKDKVAQMKDTL 328
Cdd:TIGR00606  270 EIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDcqrelEKLNKERRLLNQEKTELLVEQ 349
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   329 GQAQQRVaelEPLKEQLRGAQELAASSQQKATLLGEElasAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQW 408
Cdd:TIGR00606  350 GRLQLQA---DRHQEHIRARDSLIQSLATRLELDGFE---RGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERL 423
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   409 SKERAGLLQSVEAEKDKILKLSAEIlrLEKAVQEERT-----QNQVFKTELAREKDSSLVQlSESKRELTELRSALRVLQ 483
Cdd:TIGR00606  424 KQEQADEIRDEKKGLGRTIELKKEI--LEKKQEELKFvikelQQLEGSSDRILELDQELRK-AERELSKAEKNSLTETLK 500
                          330       340       350
                   ....*....|....*....|....*....|.
gi 767974945   484 KEKEQLQEEKQELLEYMRKLEARLEKVADEK 514
Cdd:TIGR00606  501 KEVKSLQNEKADLDRKLRKLDQEMEQLNHHT 531
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
263-405 6.35e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 43.20  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  263 REQ-EKLLGQLKEVqadKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQA-QQRVAELEP 340
Cdd:pfam07111 512 REQgEAERQQLSEV---AQQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQELTQQQEIYGQAlQEKVAEVET 588
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  341 -LKEQLRGAQEL---AASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNG-RLAELGLHLKEEK 405
Cdd:pfam07111 589 rLREQLSDTKRRlneARREQAKAVVSLRQIQHRATQEKERNQELRRLQDEARKEEGqRLARRVQELERDK 658
46 PHA02562
endonuclease subunit; Provisional
149-293 6.47e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.08  E-value: 6.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 149 LQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTEL---MEQYKGIS---RSHGE-------ITEE 215
Cdd:PHA02562 218 KQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIkskIEQFQKVIkmyEKGGVcptctqqISEG 297
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 216 RDILS--RQQGDHVARILELEDDIQtisEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQEN 293
Cdd:PHA02562 298 PDRITkiKDKLKELQHSLEKLDTAI---DELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEF 374
PTZ00121 PTZ00121
MAEBL; Provisional
171-469 6.88e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 6.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  171 EGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVE 250
Cdd:PTZ00121 1538 EAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEE 1617
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  251 LDRLRDTVKAlTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLK-----------EAKSWQEEQSAQAQRLKD 319
Cdd:PTZ00121 1618 AKIKAEELKK-AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAkkaeedkkkaeEAKKAEEDEKKAAEALKK 1696
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  320 KvAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEElasaaaarDRTIAElhRSRLEVAEVNgRLAELGL 399
Cdd:PTZ00121 1697 E-AEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEE--------DKKKAE--EAKKDEEEKK-KIAHLKK 1764
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  400 HLKEEKCQWSKERAGLLQSVEAEKDKILKLSAE-----ILRLEKAVQEERTQN--------QVFKTELAREKDSSLVQLS 466
Cdd:PTZ00121 1765 EEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDkkikdIFDNFANIIEGGKEGnlvindskEMEDSAIKEVADSKNMQLE 1844

                  ...
gi 767974945  467 ESK 469
Cdd:PTZ00121 1845 EAD 1847
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
167-498 7.50e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 7.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 167 KLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLT 246
Cdd:COG4372   12 RLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 247 KEVELDRLRDTVKALTREQEKLLGQLKEVQAdkeqseaELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKD 326
Cdd:COG4372   92 AQAELAQAQEELESLQEEAEELQEELEELQK-------ERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQE 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 327 TLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKC 406
Cdd:COG4372  165 ELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALEL 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 407 QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEK 486
Cdd:COG4372  245 EEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLEL 324
                        330
                 ....*....|..
gi 767974945 487 EQLQEEKQELLE 498
Cdd:COG4372  325 AKKLELALAILL 336
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
155-259 8.25e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.54  E-value: 8.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 155 ESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRS-HGEITEERDILSRQqgdhvARILEL 233
Cdd:COG2433  403 HEERELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEeRREIRKDREISRLD-----REIERL 477
                         90       100
                 ....*....|....*....|....*.
gi 767974945 234 EDDIQTISEKVLTKEVELDRLRDTVK 259
Cdd:COG2433  478 ERELEEERERIEELKRKLERLKELWK 503
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
154-509 1.08e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   154 DESQQERNDLMQL----KLQLEGQVTELRSRVQELEralatarQEHTELMEQYKGISRSHGEITEERDILsrqqgdhVAR 229
Cdd:pfam01576    4 EEEMQAKEEELQKvkerQQKAESELKELEKKHQQLC-------EEKNALQEQLQAETELCAEAEEMRARL-------AAR 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   230 ILELEDDIQTIsekvltkEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKS---W 306
Cdd:pfam01576   70 KQELEEILHEL-------ESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEdilL 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   307 QEEQSAQAQR----LKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHR 382
Cdd:pfam01576  143 LEDQNSKLSKerklLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQE 222
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   383 srlEVAEVNGRLAELGLHL--KEEKCQWSKERAG--LLQSVEAEKdKILKLSAEILRLEKAVQEERTQN----------- 447
Cdd:pfam01576  223 ---QIAELQAQIAELRAQLakKEEELQAALARLEeeTAQKNNALK-KIRELEAQISELQEDLESERAARnkaekqrrdlg 298
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974945   448 ---QVFKTELAREKDSSLVQL---SESKRELTELRSALRVLQKEKE-QLQE----------EKQELLEYMRKLEARLEK 509
Cdd:pfam01576  299 eelEALKTELEDTLDTTAAQQelrSKREQEVTELKKALEEETRSHEaQLQEmrqkhtqaleELTEQLEQAKRNKANLEK 377
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
151-345 1.30e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 41.72  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  151 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGdhvari 230
Cdd:pfam15905  73 KDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNELLKAKFS------ 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  231 lelEDDIQtisEKVLTKEVELDRLRDTVKALTRE----QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSW 306
Cdd:pfam15905 147 ---EDGTQ---KKMSSLSMELMKLRNKLEAKMKEvmakQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKSE 220
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767974945  307 QEEQ----------SAQAQRLKDKVAQMKDTLGQAQQrvaELEPLKEQL 345
Cdd:pfam15905 221 TEKLleyitelscvSEQVEKYKLDIAQLEELLKEKND---EIESLKQSL 266
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
137-513 1.46e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.96  E-value: 1.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   137 SDILLVVPKATVLQNQLDESQQERNDLMQLklqLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH---GEIT 213
Cdd:TIGR00606  702 SKLRLAPDKLKSTESELKKKEKRRDEMLGL---APGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQEtllGTIM 778
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   214 EERDILSRQQGDhVARILELEDDIQTISEKVLTKEVELDR--LRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQ 291
Cdd:TIGR00606  779 PEEESAKVCLTD-VTIMERFQMELKDVERKIAQQAAKLQGsdLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQE 857
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   292 ENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQ-LRGAQELAASSQQKATLLGEELASAA 370
Cdd:TIGR00606  858 QIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQdSPLETFLEKDQQEKEELISSKETSNK 937
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   371 AARDrtiaELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEkdkilkLSAEILRLEKAVQEERTQNQVF 450
Cdd:TIGR00606  938 KAQD----KVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQ------LEECEKHQEKINEDMRLMRQDI 1007
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   451 KTELARE---KDsslvQLSESKR--ELTELRSALRVLQKEKEQLQ--EEKQElleyMRKLEARLEKVADE 513
Cdd:TIGR00606 1008 DTQKIQErwlQD----NLTLRKRenELKEVEEELKQHLKEMGQMQvlQMKQE----HQKLEENIDLIKRN 1069
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
250-372 1.49e-03

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444094 [Multi-domain]  Cd Length: 747  Bit Score: 41.76  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 250 ELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLG 329
Cdd:COG5283   22 RVAALAQALKALEAPTRALARALERAKQAAARLQTKYNKLRQSLQRLRQALDQAGIDTRQLSAAQRRLRSSLEQTNRQLE 101
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 767974945 330 QAQQRVAELEPLKEQLRGA-QELAASSQQKATLLGeeLASAAAA 372
Cdd:COG5283  102 RQQQRLARLGARQDRLKAArARLQRLAGAGAAAAA--IGAALAA 143
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
261-402 1.71e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 41.25  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  261 LTREQEKLLGQLKEVQADKEQSEAELQVAQQenhhLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEP 340
Cdd:pfam00529  56 YQAALDSAEAQLAKAQAQVARLQAELDRLQA----LESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRV 131
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767974945  341 L-------------KEQLRGAQE--LAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLK 402
Cdd:pfam00529 132 LapiggisreslvtAGALVAQAQanLLATVAQLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAELKLAKLDLE 208
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
232-525 2.22e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.57  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   232 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLkeakswqeeqs 311
Cdd:TIGR00606  692 ELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDI----------- 760
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   312 aqaQRLKDKVAQMKDTLGqaqqrvaeleplkeqlrgaqelaassqqkaTLLGEELASAAAARDRTIAElhRSRLEVAEVN 391
Cdd:TIGR00606  761 ---QRLKNDIEEQETLLG------------------------------TIMPEEESAKVCLTDVTIME--RFQMELKDVE 805
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   392 GRLAELGLHLKEEKCQWSKERagLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTelarekdsslvQLSESKRE 471
Cdd:TIGR00606  806 RKIAQQAAKLQGSDLDRTVQQ--VNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKS-----------KTNELKSE 872
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767974945   472 LTELRSALRVLQKEKEQLQEEKQELLEYMRKL-EARLEKVADEKWNEDATTEDEE 525
Cdd:TIGR00606  873 KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIkDAKEQDSPLETFLEKDQQEKEE 927
GAS pfam13851
Growth-arrest specific micro-tubule binding; This family is the highly conserved central ...
401-505 2.24e-03

Growth-arrest specific micro-tubule binding; This family is the highly conserved central region of a number of metazoan proteins referred to as growth-arrest proteins. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and spermatogenesis. In humans, it is absent in infertile males who lack the ability to generate gametes. The localization of Gas8 in the motility apparatus of post-meiotic gametocytes and mature spermatozoa, together with the detection of Gas8 also in cilia at the apical surfaces of epithelial cells lining the pulmonary bronchi and Fallopian tubes suggests that the Gas8 protein may have a role in the functioning of motile cellular appendages. Gas8 is a microtubule-binding protein localized to regions of dynein regulation in mammalian cells.


Pssm-ID: 464001 [Multi-domain]  Cd Length: 200  Bit Score: 39.89  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  401 LKEEKCQwskeraglLQSVEAEKDKILK-LSAEILRLEKAVQEERTQNQVFKTELAR-EKDsslvqlsesKRELTELRSA 478
Cdd:pfam13851  31 LKEEIAE--------LKKKEERNEKLMSeIQQENKRLTEPLQKAQEEVEELRKQLENyEKD---------KQSLKNLKAR 93
                          90       100
                  ....*....|....*....|....*..
gi 767974945  479 LRVLQKEKEQLQEEKQELLEYMRKLEA 505
Cdd:pfam13851  94 LKVLEKELKDLKWEHEVLEQRFEKVER 120
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
152-386 2.56e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  152 QLDESQQERNDLMQLKLQLEgqvtelRSRVQELERaLATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARIL 231
Cdd:pfam17380 354 RQEERKRELERIRQEEIAME------ISRMRELER-LQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIR 426
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  232 ELEDDIQTISEKVLTKE--VELDRLRDTVKALTREQEKLLGQ---LKEVQADKEQSEAELQVAQQENHH-LNLDLKEAKS 305
Cdd:pfam17380 427 AEQEEARQREVRRLEEEraREMERVRLEEQERQQQVERLRQQeeeRKRKKLELEKEKRDRKRAEEQRRKiLEKELEERKQ 506
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  306 WQEEQSAQAQRLKDKVAQMKDTLGQAQQ-RVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARD--RTIAELHR 382
Cdd:pfam17380 507 AMIEEERKRKLLEKEMEERQKAIYEEERrREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREmmRQIVESEK 586

                  ....
gi 767974945  383 SRLE 386
Cdd:pfam17380 587 ARAE 590
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
152-457 2.61e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 2.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 152 QLDESQQERNdlmqlklQLEGQVTELRSRVQELERALATARQEHTELMEQYKgisrshgEITEERDILSRQQGDHVARIL 231
Cdd:COG4372   39 ELDKLQEELE-------QLREELEQAREELEQLEEELEQARSELEQLEEELE-------ELNEQLQAAQAELAQAQEELE 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 232 ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAEL-----QVAQQENHHLNLDLKEAKSW 306
Cdd:COG4372  105 SLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLeslqeELAALEQELQALSEAEAEQA 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 307 QEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLE 386
Cdd:COG4372  185 LDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELE 264
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767974945 387 VAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELARE 457
Cdd:COG4372  265 LAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAIL 335
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
247-366 2.88e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 40.35  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  247 KEVELDRLRDTVKALTrEQEKllgQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQaqrLKDKVAQMKD 326
Cdd:pfam02841 185 KEAVEEAILQTDQALT-AKEK---AIEAERAKAEAAEAEQELLREKQKEEEQMMEAQERSYQEHVKQ---LIEKMEAERE 257
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767974945  327 TLGQAQQRVAELEpLKEQLRgaqELAASSQQKATLLGEEL 366
Cdd:pfam02841 258 QLLAEQERMLEHK-LQEQEE---LLKEGFKTEAESLQKEI 293
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
120-385 3.04e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.19  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  120 EPRPMDELVTLEEADggSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELm 199
Cdd:PRK10929   94 EPRSVPPNMSTDALE--QEILQVSSQLLEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEIERRLQTLGTPNTPL- 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  200 eqykgisrshgeitEERDILSRQ--QGDHVARILELEddiqtISEKVLTKEVELDRLRDTVKALTREQ-EKLLGQLKEVQ 276
Cdd:PRK10929  171 --------------AQAQLTALQaeSAALKALVDELE-----LAQLSANNRQELARLRSELAKKRSQQlDAYLQALRNQL 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  277 ADKEQSEAEL------QVAQQ---------ENHHLNLDLKEAkswqeeQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPL 341
Cdd:PRK10929  232 NSQRQREAERalesteLLAEQsgdlpksivAQFKINRELSQA------LNQQAQRMDLIASQQRQAASQTLQVRQALNTL 305
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767974945  342 KEQlrgAQELAASsqqkaTLLGEELaSAAAAR----------DRTIAELHRSRL 385
Cdd:PRK10929  306 REQ---SQWLGVS-----NALGEAL-RAQVARlpempkpqqlDTEMAQLRVQRL 350
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
216-443 3.24e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 40.83  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 216 RDILsrqqgDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQAdkeqseaelqvaqqenhh 295
Cdd:COG0497  144 RELL-----DAFAGLEELLEEYREAYRAWRALKKELEELRADEAERARELDLLRFQLEELEA------------------ 200
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 296 LNLDLKEAKSWQEEQS--AQAQRLKDKVAQMK-----------DTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLL 362
Cdd:COG0497  201 AALQPGEEEELEEERRrlSNAEKLREALQEALealsggeggalDLLGQALRALERLAEYDPSLAELAERLESALIELEEA 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 363 GEELASAAAArdrtiAELHRSRLEvaEVNGRLAELgLHLK-------EEKCQWSKERAGLLQSVEAEKDKILKLSAEILR 435
Cdd:COG0497  281 ASELRRYLDS-----LEFDPERLE--EVEERLALL-RRLArkygvtvEELLAYAEELRAELAELENSDERLEELEAELAE 352

                 ....*...
gi 767974945 436 LEKAVQEE 443
Cdd:COG0497  353 AEAELLEA 360
PRK12472 PRK12472
hypothetical protein; Provisional
252-372 3.25e-03

hypothetical protein; Provisional


Pssm-ID: 237110 [Multi-domain]  Cd Length: 508  Bit Score: 40.62  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 252 DRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQEnhhlnldLKEAKSwqEEQSAQAQRLKDKVAQmkdtlgQA 331
Cdd:PRK12472 207 DEAKTAAAAAAREAAPLKASLRKLERAKARADAELKRADKA-------LAAAKT--DEAKARAEERQQKAAQ------QA 271
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767974945 332 QQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAA 372
Cdd:PRK12472 272 AEAATQLDTAKADAEAKRAAAAATKEAAKAAAAKKAETAKA 312
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
301-513 3.26e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.11  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   301 KEAKSWQEEQSAQAQRLKDKVAQMKDT-----------LGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASA 369
Cdd:TIGR00618  190 KSLHGKAELLTLRSQLLTLCTPCMPDTyherkqvlekeLKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARI 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   370 AAARDRTIA-ELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGlLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQ 448
Cdd:TIGR00618  270 EELRAQEAVlEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTE-LQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQ 348
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767974945   449 VFKTE---LAREKDSSLVQLSESKRElTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADE 513
Cdd:TIGR00618  349 TLHSQeihIRDAHEVATSIREISCQQ-HTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTR 415
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
151-513 3.57e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.67  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  151 NQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRshgEITEERDILSRQQGDHVARI 230
Cdd:COG4913   338 DRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLE---ALEEELEALEEALAEAEAAL 414
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  231 LELEDDIQTISEkvltkevELDRLRDTVKALTREQEKLLGQLKEvQADKEQSE----AEL-QVAQQE------------N 293
Cdd:COG4913   415 RDLRRELRELEA-------EIASLERRKSNIPARLLALRDALAE-ALGLDEAElpfvGELiEVRPEEerwrgaiervlgG 486
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  294 HHLNL-----DLKEAKSW----QEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELE----P----LKEQLRG--------- 347
Cdd:COG4913   487 FALTLlvppeHYAAALRWvnrlHLRGRLVYERVRTGLPDPERPRLDPDSLAGKLDfkphPfrawLEAELGRrfdyvcvds 566
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  348 AQELA---------------ASSQQKAT--------LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEE 404
Cdd:COG4913   567 PEELRrhpraitragqvkgnGTRHEKDDrrrirsryVLGFDNRAKLAALEAELAELEEELAEAEERLEALEAELDALQER 646
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  405 KCQWSKeragLLQSVEAEKDkILKLSAEILRLEKAVQEERTQNQVFKtELARekdsslvQLSESKRELTELRSALRVLQK 484
Cdd:COG4913   647 REALQR----LAEYSWDEID-VASAEREIAELEAELERLDASSDDLA-ALEE-------QLEELEAELEELEEELDELKG 713
                         410       420
                  ....*....|....*....|....*....
gi 767974945  485 EKEQLQEEKQELLEYMRKLEARLEKVADE 513
Cdd:COG4913   714 EIGRLEKELEQAEEELDELQDRLEAAEDL 742
mukB PRK04863
chromosome partition protein MukB;
228-496 3.62e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 40.71  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  228 ARILELEDDIQTISEKVLTKEVELDRLRDTVKALTReqekLLGQLKEV--QADkeqSEAELQVAQQENHHLNLDLKEAKS 305
Cdd:PRK04863  786 KRIEQLRAEREELAERYATLSFDVQKLQRLHQAFSR----FIGSHLAVafEAD---PEAELRQLNRRRVELERALADHES 858
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  306 WQEEQSAQAQRLKDKVAQMKDTLGQA--------QQRVAELEplkEQLRGAQELAASSQQKATLLG--EELASAAAARDR 375
Cdd:PRK04863  859 QEQQQRSQLEQAKEGLSALNRLLPRLnlladetlADRVEEIR---EQLDEAEEAKRFVQQHGNALAqlEPIVSVLQSDPE 935
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  376 TIAELHRSRLE--------------VAEVNGRLAelglHLKEEKCQwskeragllQSVEAEKDKILKLSAeilRLEKAVQ 441
Cdd:PRK04863  936 QFEQLKQDYQQaqqtqrdakqqafaLTEVVQRRA----HFSYEDAA---------EMLAKNSDLNEKLRQ---RLEQAEQ 999
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767974945  442 EERTQnqvfkTELAREKDSslvQLSESKRELTELRSALRVLQkekEQLQEEKQEL 496
Cdd:PRK04863 1000 ERTRA-----REQLRQAQA---QLAQYNQVLASLKSSYDAKR---QMLQELKQEL 1043
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
460-514 3.78e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 40.10  E-value: 3.78e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767974945 460 SSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK 514
Cdd:COG4026  125 QNIPEYNELREELLELKEKIDEIAKEKEKLTKENEELESELEELREEYKKLREEN 179
ADIP pfam11559
Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at ...
420-510 3.96e-03

Afadin- and alpha -actinin-Binding; This family is found in mammals where it is localized at cell-cell adherens junctions, and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins localized at Cell-Cell Adherens Junctions.


Pssm-ID: 463295 [Multi-domain]  Cd Length: 151  Bit Score: 38.45  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  420 EAEKDKILKLSAEILRLEKAVQEERTQNQvfktELAREKDSSLVQLSESKRELTELRSALR----VLQKEKEQLQEEKQE 495
Cdd:pfam11559  55 ESLNETIRTLEAEIERLQSKIERLKTQLE----DLERELALLQAKERQLEKKLKTLEQKLKnekeELQRLKNALQQIKTQ 130
                          90
                  ....*....|....*
gi 767974945  496 LLEYMRKLEARLEKV 510
Cdd:pfam11559 131 FAHEVKKRDREIEKL 145
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
324-508 4.17e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 40.05  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  324 MKDTLGQAQQRVAELEPLKEQL--------RGAQELAASSQQKA---TLLGEELASAAAARDrtiaELHRSRLEVAEVNG 392
Cdd:pfam19220   8 LRVRLGEMADRLEDLRSLKADFsqliepieAILRELPQAKSRLLeleALLAQERAAYGKLRR----ELAGLTRRLSAAEG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  393 RLAELGLHLKEEkcqwskerAGLLQSVEAEKDKI----LKLSAEILRLEKAVQEERTQNQVFKTELAR---EKDSSLVQL 465
Cdd:pfam19220  84 ELEELVARLAKL--------EAALREAEAAKEELrielRDKTAQAEALERQLAAETEQNRALEEENKAlreEAQAAEKAL 155
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 767974945  466 SESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLE 508
Cdd:pfam19220 156 QRAEGELATARERLALLEQENRRLQALSEEQAAELAELTRRLA 198
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
185-504 4.19e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 40.71  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  185 ERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVAriLELEDDiqtisekvltKEVELDRLRDTVKALTRE 264
Cdd:COG3096   784 EKRLEELRAERDELAEQYAKASFDVQKLQRLHQAFSQFVGGHLA--VAFAPD----------PEAELAALRQRRSELERE 851
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  265 QEKLLGQLKEVQADKEQSEAELQVAQQENHHLNL----DLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAEL-- 338
Cdd:COG3096   852 LAQHRAQEQQLRQQLDQLKEQLQLLNKLLPQANLladeTLADRLEELREELDAAQEAQAFIQQHGKALAQLEPLVAVLqs 931
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  339 -----EPLKEQLRGAQELAASSQQKATLLGE----------ELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKE 403
Cdd:COG3096   932 dpeqfEQLQADYLQAKEQQRRLKQQIFALSEvvqrrphfsyEDAVGLLGENSDLNEKLRARLEQAEEARREAREQLRQAQ 1011
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  404 EKC-QWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEErtqnqvfKTELAREKDSSLVQlseskrELTELRSALRVL 482
Cdd:COG3096  1012 AQYsQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADAE-------AEERARIRRDELHE------ELSQNRSRRSQL 1078
                         330       340
                  ....*....|....*....|..
gi 767974945  483 QKEKEQLQEEKQELLEYMRKLE 504
Cdd:COG3096  1079 EKQLTRCEAEMDSLQKRLRKAE 1100
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
155-513 4.84e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 40.22  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  155 ESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISR-------SHGEITEE-----RDILSR- 221
Cdd:pfam06160  83 KAKKALDEIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKYRELRKtllanrfSYGPAIDElekqlAEIEEEf 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  222 -------QQGDHVA----------RILELEDDIQTISE--KVLTKEV--ELDRLRDTVKALTREQEKllgqLKEVQADKE 280
Cdd:pfam06160 163 sqfeeltESGDYLEarevlekleeETDALEELMEDIPPlyEELKTELpdQLEELKEGYREMEEEGYA----LEHLNVDKE 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  281 QSEAELQVAQQENHHLNLDLKEAkswqeeqSAQAQRLKDKVAQMKDTLG---QAQQRVAE--------LEPLKEQLRGAQ 349
Cdd:pfam06160 239 IQQLEEQLEENLALLENLELDEA-------EEALEEIEERIDQLYDLLEkevDAKKYVEKnlpeiedyLEHAEEQNKELK 311
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  350 ELAASSQQKATLLGEELASAAAArDRTIAELHRSRLEVAEV--NGRLA--ELGLHLKEekcqwskeragLLQSVEAEKDK 425
Cdd:pfam06160 312 EELERVQQSYTLNENELERVRGL-EKQLEELEKRYDEIVERleEKEVAysELQEELEE-----------ILEQLEEIEEE 379
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  426 ILKLSAEILRLEKAVQEERTQNQVFKTElarekdsslvqLSESKRELtelrsalrvlqkEKEQLQEEKQELLEYMRKLEA 505
Cdd:pfam06160 380 QEEFKESLQSLRKDELEAREKLDEFKLE-----------LREIKRLV------------EKSNLPGLPESYLDYFFDVSD 436

                  ....*...
gi 767974945  506 RLEKVADE 513
Cdd:pfam06160 437 EIEDLADE 444
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
373-511 5.92e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 39.84  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 373 RDRTIAELHRSrLEVAEVNGRLAELGLHLKEEKCQWSKERAGllQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKT 452
Cdd:COG2433  365 RDEVKARVIRG-LSIEEALEELIEKELPEEEPEAEREKEHEE--RELTEEEEEIRRLEEQVERLEAEVEELEAELEEKDE 441
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767974945 453 ELAR-EKDSSLVQLSESK-----RELTELRSALRVLQKEKEQLQEEKQEL------LEYMRKLEARLEKVA 511
Cdd:COG2433  442 RIERlERELSEARSEERReirkdREISRLDREIERLERELEEERERIEELkrklerLKELWKLEHSGELVP 512
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
373-504 6.04e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 39.91  E-value: 6.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 373 RDRTIAELHrsrlevaevngrlaELGL-HLKEEKCQWSKERAGLLQSveaekdKILKLSAEILRLEKAVQEERTqnqVFK 451
Cdd:PRK05771  18 KDEVLEALH--------------ELGVvHIEDLKEELSNERLRKLRS------LLTKLSEALDKLRSYLPKLNP---LRE 74
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767974945 452 TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLE 504
Cdd:PRK05771  75 EKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLE 127
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
171-339 6.38e-03

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 39.26  E-value: 6.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 171 EGQV------TELRSRVQELERALATARQEHTELmeqykgisrshgeiteerdilsRQQGDHVARILELEDDIQTISEKV 244
Cdd:COG1566   69 KGQVlarldpTDLQAALAQAEAQLAAAEAQLARL----------------------EAELGAEAEIAAAEAQLAAAQAQL 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 245 LTKEVELDRLRDTVK--ALTREQekllgqLKEVQADKEQSEAELQVAQQenhhlNLDLKEAKSWQEEQSAQAQRlkdKVA 322
Cdd:COG1566  127 DLAQRELERYQALYKkgAVSQQE------LDEARAALDAAQAQLEAAQA-----QLAQAQAGLREEEELAAAQA---QVA 192
                        170
                 ....*....|....*..
gi 767974945 323 QMKDTLGQAQQRVAELE 339
Cdd:COG1566  193 QAEAALAQAELNLARTT 209
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
374-526 7.40e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.12  E-value: 7.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 374 DRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFK-- 451
Cdd:COG4372    2 DRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEee 81
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767974945 452 -TELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEA 526
Cdd:COG4372   82 lEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEE 157
ATG16 pfam08614
Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for ...
330-498 7.52e-03

Autophagy protein 16 (ATG16); Autophagy is a ubiquitous intracellular degradation system for eukaryotic cells. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. ATG16 (also known as Apg16) has been shown to be bind to Apg5 and is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway.


Pssm-ID: 462536 [Multi-domain]  Cd Length: 176  Bit Score: 37.99  E-value: 7.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  330 QAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRtiAELHRSRLEVAEVNGRLAELGLHLKEEkcqwS 409
Cdd:pfam08614  11 RLLDRTALLEAENAKLQSEPESVLPSTSSSKLSKASPQSASIQSLE--QLLAQLREELAELYRSRGELAQRLVDL----N 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  410 KERAGLLQSVEAEKDKILKLSAEILRLEKAVQEertqnqvfKTELAREKDSSLVQLsesKRELTELRSALRVLQKEKEQL 489
Cdd:pfam08614  85 EELQELEKKLREDERRLAALEAERAQLEEKLKD--------REEELREKRKLNQDL---QDELVALQLQLNMAEEKLRKL 153

                  ....*....
gi 767974945  490 QEEKQELLE 498
Cdd:pfam08614 154 EKENRELVE 162
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
280-373 7.53e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 39.93  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  280 EQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRgAQELAASSQQKA 359
Cdd:PRK11448  138 EDPENLLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQ-EKAAETSQERKQ 216
                          90
                  ....*....|....
gi 767974945  360 TLlgEELASAAAAR 373
Cdd:PRK11448  217 KR--KEITDQAAKR 228
COG4995 COG4995
Uncharacterized conserved protein, contains CHAT domain [Function unknown];
130-503 7.83e-03

Uncharacterized conserved protein, contains CHAT domain [Function unknown];


Pssm-ID: 444019 [Multi-domain]  Cd Length: 711  Bit Score: 39.57  E-value: 7.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 130 LEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
Cdd:COG4995   98 LAAAALAALALLAALLALAAAAALLALLAALALLALLAALAAALAAAAAAALAAALAAAAAAAAAAALLALALALAAAAL 177
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 210 GEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVA 289
Cdd:COG4995  178 ALLALLLAALAAALAAAAAALALLLALLLLAALAAALAAALAALLLALLALAAALLALLLLALLALAAAAAALAAAAAAL 257
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 290 QQENHHLNLDLKEAksWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASA 369
Cdd:COG4995  258 LALAAALLLLAALA--ALAAAAAAAALAALALAAALALAAAALALALLLAAAAAAALAALALLLLAALLLLLAALALLAL 335
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 370 AAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQV 449
Cdd:COG4995  336 LLLLAAAALLAAALAAALALAAALALALLAALLLLLAALLALLLEALLLLLLALLAALLLLAAALLALAAAQLLRLLLAA 415
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767974945 450 FKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKL 503
Cdd:COG4995  416 LALLLALAAYAAARLALLALIEYIILPDRLYAFVQLYQLLIAPIEAELPGIKRL 469
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
130-257 8.51e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.51  E-value: 8.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  130 LEEADGGSDILlvvpkaTVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSH 209
Cdd:COG4913   677 LERLDASSDDL------AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRAL 750
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767974945  210 GEITEERDILSRQQGDHVARileLEDDIQTISEKVLTKEVELDRLRDT 257
Cdd:COG4913   751 LEERFAAALGDAVERELREN---LEERIDALRARLNRAEEELERAMRA 795
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
125-396 8.97e-03

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 39.23  E-value: 8.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 125 DELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKG 204
Cdd:COG0840  108 ALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALLEAAALALAAAALALALLAAA 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 205 ISRSHGEITEERDILSRQQgdhVARILELEDDIQTISEKVLTKEVELDRlRDTVKALTREQEKLLGQLKEVQADKEQSEA 284
Cdd:COG0840  188 LLALVALAIILALLLSRSI---TRPLRELLEVLERIAEGDLTVRIDVDS-KDEIGQLADAFNRMIENLRELVGQVRESAE 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945 285 ELQVAQQENHHLNLDLKEAkswQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAEleplkeqlrgAQELAASSQQKATLLGE 364
Cdd:COG0840  264 QVASASEELAASAEELAAG---AEEQAASLEETAAAMEELSATVQEVAENAQQ----------AAELAEEASELAEEGGE 330
                        250       260       270
                 ....*....|....*....|....*....|..
gi 767974945 365 ELASAAAArdrtIAELHRSRLEVAEVNGRLAE 396
Cdd:COG0840  331 VVEEAVEG----IEEIRESVEETAETIEELGE 358
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
150-513 9.49e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 39.64  E-value: 9.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   150 QNQLDESQQERNDLMQLKLQLEGQVTELR---SRVQELERALATARQE---HTELmEQYKGISRSHGEITEERDILSRQQ 223
Cdd:TIGR00606  325 QRELEKLNKERRLLNQEKTELLVEQGRLQlqaDRHQEHIRARDSLIQSlatRLEL-DGFERGPFSERQIKNFHTLVIERQ 403
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   224 GDHVARILELEDDIQtisEKVLTKEVELDRLRDTVKALTR----EQEKL---LGQLKEVQADKEQSEAELQVAQQENHHL 296
Cdd:TIGR00606  404 EDEAKTAAQLCADLQ---SKERLKQEQADEIRDEKKGLGRtielKKEILekkQEELKFVIKELQQLEGSSDRILELDQEL 480
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   297 -----NLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLL-------GE 364
Cdd:TIGR00606  481 rkaerELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIrkiksrhSD 560
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   365 ELASAAAA---RDRTIAELHRSRLEVAEVNGRLAELglhlkeekcqwSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQ 441
Cdd:TIGR00606  561 ELTSLLGYfpnKKQLEDWLHSKSKEINQTRDRLAKL-----------NKELASLEQNKNHINNELESKEEQLSSYEDKLF 629
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945   442 EErTQNQVFKTELAREKDsslvQLSESKRELTELRSALRVLQKEKEQLQEEKQ--------------ELLEYMRKLEARL 507
Cdd:TIGR00606  630 DV-CGSQDEESDLERLKE----EIEKSSKQRAMLAGATAVYSQFITQLTDENQsccpvcqrvfqteaELQEFISDLQSKL 704

                   ....*.
gi 767974945   508 EKVADE 513
Cdd:TIGR00606  705 RLAPDK 710
CENP-K pfam11802
Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) ...
242-367 9.59e-03

Centromere-associated protein K; CENP-K is one of seven new CENP-A-nucleosome distal (CAD) centromere components (the others being CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) that are identified as assembling on the CENP-A nucleosome associated complex, NAC. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling. CENP-K is centromere-associated through its interaction with one or more components of the CENP-A NAC.


Pssm-ID: 463355 [Multi-domain]  Cd Length: 263  Bit Score: 38.51  E-value: 9.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  242 EKVLTKEVElDRLRDTVKALTREQEKLLGQLK-EVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDK 320
Cdd:pfam11802  55 VKALTAELE-QWQKRTPEIISLNPEVLLTLGKeELQKLRHQLEMVLSTIQSKNKKLKEDLEREQQWLDEQQQILESLNEK 133
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767974945  321 VAQMKDTLGQAQQRVAELEpLKEQLRGAQELaasSQQKATLLGEELA 367
Cdd:pfam11802 134 HKELKNQVVTFSEKRKFQE-LKTKIRKIKEY---KEKLLTTLGEFLD 176
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
149-345 9.60e-03

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 39.45  E-value: 9.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  149 LQNQLDES----QQERNDLMQLKLQLEGqvtELRSRVQeLERALATAR----QEHTELMEQYKGISRSHGEITEerdILS 220
Cdd:pfam09726 449 LQTKLHNAvsakQKDKQTVQQLEKRLKA---EQEARAS-AEKQLAEEKkrkkEEEATAARAVALAAASRGECTE---SLK 521
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974945  221 RqqgdhvaRILELEDDIQTISEKVLTKEVELDRLRDTVKALTreqekllgQLKEVQADKEQSEAELQVAQQENHHLnldl 300
Cdd:pfam09726 522 Q-------RKRELESEIKKLTHDIKLKEEQIRELEIKVQELR--------KYKESEKDTEVLMSALSAMQDKNQHL---- 582
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767974945  301 keakswqeEQSAQAQ-RLK--------DKVAQMKDTLGQAQQRVAELEPLKEQL 345
Cdd:pfam09726 583 --------ENSLSAEtRIKldlfsalgDAKRQLEIAQGQIYQKDQEIKDLKQKI 628
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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