|
Name |
Accession |
Description |
Interval |
E-value |
| FYVE_EEA1 |
cd15730 |
FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins; EEA1, also termed ... |
1389-1451 |
4.36e-43 |
|
FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins; EEA1, also termed endosome-associated protein p162, or zinc finger FYVE domain-containing protein 2, is an essential component of the endosomal fusion machinery and required for the fusion and maturation of early endosomes in endocytosis. It forms a parallel coiled-coil homodimer in cells. EEA1 serves as the p97 ATPase substrate and the p97 ATPase may regulate the size of early endosomes by governing the oligomeric state of EEA1. It can interact with the GTP-bound form of Rab22a and be involved in endosomal membrane trafficking. EEA1 also functions as an obligate scaffold for angiotensin II-induced Akt activation in early endosomes. It can be phosphorylated by p38 mitogen-activated protein kinase (MAPK) and further regulate mu opioid receptor endocytosis. EEA1 consists of an N-terminal C2H2 Zn2+ finger, four long heptad repeats, and a C-terminal region containing a calmodulin binding (IQ) motif, a Rab5 interaction site, and a FYVE domain. This model corresponds to the FYVE domain that is responsible for binding phosphatidyl inositol-3-phosphate (PtdIns3P or PI3P) on the membrane.
Pssm-ID: 277269 [Multi-domain] Cd Length: 63 Bit Score: 150.63 E-value: 4.36e-43
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1389 RKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDL 1451
Cdd:cd15730 1 RKWADDEEVQNCMACGKGFSVTVRKHHCRQCGNIFCNECSSKTATTPSSKKPVRVCDACFDDL 63
|
|
| FYVE |
pfam01363 |
FYVE zinc finger; The FYVE zinc finger is named after four proteins that it has been found in: ... |
1390-1452 |
3.40e-28 |
|
FYVE zinc finger; The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.
Pssm-ID: 426221 [Multi-domain] Cd Length: 68 Bit Score: 108.62 E-value: 3.40e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 1390 KWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTP---SSKKPVRVCDACFNDLQ 1452
Cdd:pfam01363 2 VWVPDSSATVCMICSKPFTFFRRRHHCRNCGRVFCSACSSKKISLLpelGSNKPVRVCDACYDTLQ 67
|
|
| FYVE |
smart00064 |
Protein present in Fab1, YOTB, Vac1, and EEA1; The FYVE zinc finger is named after four ... |
1388-1453 |
5.44e-28 |
|
Protein present in Fab1, YOTB, Vac1, and EEA1; The FYVE zinc finger is named after four proteins where it was first found: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn2+ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. The FYVE finger is structurally related to the PHD finger and the RING finger. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. The FYVE finger functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is prominent on endosomes. The R+HHC+XCG motif is critical for PI3P binding.
Pssm-ID: 214499 [Multi-domain] Cd Length: 68 Bit Score: 107.90 E-value: 5.44e-28
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 1388 NRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSS--KKPVRVCDACFNDLQG 1453
Cdd:smart00064 1 RPHWIPDEEVSNCMGCGKEFNLTKRRHHCRNCGRIFCSKCSSKKAPLPKLgiERPVRVCDDCYENLNG 68
|
|
| FYVE_RUFY1_like |
cd15721 |
FYVE domain found in RUN and FYVE domain-containing protein RUFY1, RUFY2 and similar proteins; ... |
1391-1448 |
1.92e-25 |
|
FYVE domain found in RUN and FYVE domain-containing protein RUFY1, RUFY2 and similar proteins; This family includes RUN and FYVE domain-containing protein RUFY1 and RUFY2. RUFY1, also termed FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homologue of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY2, also termed Rab4-interacting protein related, is a novel embryonic factor that is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions. Both RUFY1 and RUFY2 contain an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between.
Pssm-ID: 277261 [Multi-domain] Cd Length: 58 Bit Score: 100.15 E-value: 1.92e-25
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACF 1448
Cdd:cd15721 1 WADDKEVTHCQQCEKEFSLSRRKHHCRNCGGIFCNSCSDNTMPLPSSAKPVRVCDTCY 58
|
|
| FYVE_PKHF |
cd15717 |
FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1), 2 (phafin-2), ... |
1391-1448 |
1.05e-21 |
|
FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1), 2 (phafin-2), and similar proteins; This family includes protein containing both PH and FYVE domains 1 (phafin-1) and 2 (phafin-2). Phafin-1 is a representative of a novel family of PH and FYVE domain-containing proteins called phafins. It is a ubiquitously expressed pro-apoptotic protein via translocating to lysosomes, facilitating apoptosis induction through a lysosomal-mitochondrial apoptotic pathway. Phafin-2 is a ubiquitously expressed endoplasmic reticulum-associated protein that facilitates tumor necrosis factor alpha (TNF-alpha)-triggered cellular apoptosis through endoplasmic reticulum (ER)-mitochondrial apoptotic pathway. It is an endosomal phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) effector, as well as an interactor of the endosomal-tethering protein EEA1. It regulates endosome fusion upstream of Rab5. Phafin-2 also functions as a novel regulator of endocytic epidermal growth factor receptor (EGFR) degradation through a role in endosomal fusion.
Pssm-ID: 277257 [Multi-domain] Cd Length: 61 Bit Score: 89.73 E-value: 1.05e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1391 WAEDNEVQNCMACGKG-FSVTVRRHHCRQCGNIFCAECSAKNALTPS-SKKPVRVCDACF 1448
Cdd:cd15717 2 WVPDSEAPVCMHCKKTkFTAINRRHHCRKCGAVVCGACSSKKFLLPHqSSKPLRVCDTCY 61
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
651-1382 |
1.12e-21 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 102.44 E-value: 1.12e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 651 LRAAQDRVLSLETSVNELNSQLNeSKEKVSQLDIQIKAKTELLLSAEAAKTAQRAD-LQNHLDTAQNALQDKQQELNKIT 729
Cdd:TIGR02168 181 LERTRENLDRLEDILNELERQLK-SLERQAEKAERYKELKAELRELELALLVLRLEeLREELEELQEELKEAEEELEELT 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 730 TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 809
Cdd:TIGR02168 260 AELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEEL 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 810 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQetkiQHEELNNRIQTTVTELQKVKME 889
Cdd:TIGR02168 340 AELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL----QIASLNNEIERLEARLERLEDR 415
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 890 KEALMTELSTVKDKLSkvsdslKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASH 969
Cdd:TIGR02168 416 RERLQQEIEELLKKLE------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQA 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 970 QLKLeLNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS---SEQKKKQIEALQGELKIAVLQKTE---------LENK 1037
Cdd:TIGR02168 490 RLDS-LERLQENLEGFSEGVKALLKNQSGLSGILGVLSELisvDEGYEAAIEAALGGRLQAVVVENLnaakkaiafLKQN 568
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1038 LQQQLTQAAQELAAEKEkISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS---VEEKLSLAQEDLISNR----- 1109
Cdd:TIGR02168 569 ELGRVTFLPLDSIKGTE-IQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGgvlVVDDLDNALELAKKLRpgyri 647
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1110 ----------------------NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1167
Cdd:TIGR02168 648 vtldgdlvrpggvitggsaktnSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQ 727
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1168 LAEIEEIKCRQEKEITKLNEELKSHKlesiKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE 1247
Cdd:TIGR02168 728 ISALRKDLARLEAEVEQLEERIAQLS----KELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALRE 803
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1248 ELKKEFIEKEAkLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATV 1327
Cdd:TIGR02168 804 ALDELRAELTL-LNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNER 882
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 1328 QNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1382
Cdd:TIGR02168 883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVR 937
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
417-1195 |
1.42e-21 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 102.44 E-value: 1.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 417 QKLKEELSEVETKYQHLKAEFKQ---LQQQREEKEQHGLQLQS-EINQLHSKLLETERQLGEAHGRLKEqrqlSSEKLMD 492
Cdd:TIGR02168 189 DRLEDILNELERQLKSLERQAEKaerYKELKAELRELELALLVlRLEELREELEELQEELKEAEEELEE----LTAELQE 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 493 KEQQVADLQLKLSRLEEQLkekvtnsTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEA 572
Cdd:TIGR02168 265 LEEKLEELRLEVSELEEEI-------EELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAE 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 573 LLQKSKENISLLEKEREDLYAKIQAGEgetAVLNQLQEKNHTLQEQVTQLTEKLKnqseSHKQAQENLHDQVQEQKAHLR 652
Cdd:TIGR02168 338 ELAELEEKLEELKEELESLEAELEELE---AELEELESRLEELEEQLETLRSKVA----QLELQIASLNNEIERLEARLE 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 653 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIqikaktelllsaeAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 732
Cdd:TIGR02168 411 RLEDRRERLQQEIEELLKKLEEAELKELQAEL-------------EELEEELEELQEELERLEEALEELREELEEAEQAL 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 733 DQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG--QIKKLEADSLEVKASKEQALQDLQQQRQLN---TDLEL 807
Cdd:TIGR02168 478 DAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsGILGVLSELISVDEGYEAAIEAALGGRLQAvvvENLNA 557
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 808 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNN-RIQTTVTELQKV 886
Cdd:TIGR02168 558 AKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGvLVVDDLDNALEL 637
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 887 KMEKEALMTeLSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK---HQLQVQMENTLKEQKELKKSLEK 963
Cdd:TIGR02168 638 AKKLRPGYR-IVTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEekiAELEKALAELRKELEELEEELEQ 716
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 964 EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEnklqQQLT 1043
Cdd:TIGR02168 717 LRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE----AQIE 792
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1044 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1123
Cdd:TIGR02168 793 QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELE 872
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975501 1124 TAKATLEQDSAKKEQQLQERCKALQDIQKEkslkekelvnekskLAEIEEIKCRQEKEITKLNEELKSHKLE 1195
Cdd:TIGR02168 873 SELEALLNERASLEEALALLRSELEELSEE--------------LRELESKRSELRRELEELREKLAQLELR 930
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
542-1376 |
2.91e-21 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 101.29 E-value: 2.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 542 TTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLlEKEREDLYAKIQAGEgetavLNQLQEKNHTLQEQVTQ 621
Cdd:TIGR02168 177 TERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKEL-KAELRELELALLVLR-----LEELREELEELQEELKE 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 622 LTEKLKNQSESHKQAQ---ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTElllsaea 698
Cdd:TIGR02168 251 AEEELEELTAELQELEeklEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEA------- 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 699 aktaQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 778
Cdd:TIGR02168 324 ----QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLN 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 779 ADSLEVKASKEQALQDLQQQRQLNTDL-----ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKI 853
Cdd:TIGR02168 400 NEIERLEARLERLEDRRERLQQEIEELlkkleEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDA 479
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 854 LKQDFETLSQETKIQhEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLskvsdslknsksEFEKENQKGKAAILDle 933
Cdd:TIGR02168 480 AERELAQLQARLDSL-ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELI------------SVDEGYEAAIEAALG-- 544
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 934 ktckelKHQLQVQMENtlKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEqqLQGNINELKQSSEQK 1013
Cdd:TIGR02168 545 ------GRLQAVVVEN--LNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEG--FLGVAKDLVKFDPKL 614
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1014 KKQIEALQGELKIAvlqkTELENKLQQQLTQAAQEL-----------------AAEKEKISVLQNNYEksqetFKQLQSD 1076
Cdd:TIGR02168 615 RKALSYLLGGVLVV----DDLDNALELAKKLRPGYRivtldgdlvrpggvitgGSAKTNSSILERRRE-----IEELEEK 685
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1077 FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1156
Cdd:TIGR02168 686 IEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1157 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKShkleSIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1236
Cdd:TIGR02168 766 LEERLEEAEEELAEAEAEIEELEAQIEQLKEELKA----LREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1237 ILKDQVKKEEEELKK------EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1310
Cdd:TIGR02168 842 DLEEQIEELSEDIESlaaeieELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELR 921
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 1311 KQTDDLRGEIAVLEATVQNNQDERRALLERCLKG-EGEIEKLQTKVLELQRKLDNTTAAVQELGREN 1376
Cdd:TIGR02168 922 EKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEaEALENKIEDDEEEARRRLKRLENKIKELGPVN 988
|
|
| FYVE_LST2 |
cd15731 |
FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins; ... |
1391-1449 |
1.27e-20 |
|
FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins; Lst2, also termed zinc finger FYVE domain-containing protein 28, is a monoubiquitinylated phosphoprotein that functions as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Unlike other FYVE domain-containing proteins, Lst2 displays primarily non-endosomal localization. Its endosomal localization is regulated by monoubiquitinylation. Lst2 physically binds Trim3, also known as BERP or RNF22, which is a coordinator of endosomal trafficking and interacts with Hrs and a complex that biases cargo recycling.
Pssm-ID: 277270 [Multi-domain] Cd Length: 65 Bit Score: 86.63 E-value: 1.27e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK--KPVRVCDACFN 1449
Cdd:cd15731 5 WVPDEACPQCMACSAPFTVLRRRHHCRNCGKIFCSRCSSNSVPLPRYGqmKPVRVCNHCFM 65
|
|
| FYVE_like_SF |
cd00065 |
FYVE domain like superfamily; FYVE domain is a 60-80 residue double zinc finger ... |
1399-1448 |
1.58e-20 |
|
FYVE domain like superfamily; FYVE domain is a 60-80 residue double zinc finger motif-containing module named after the four proteins, Fab1, YOTB, Vac1, and EEA1. The canonical FYVE domains are distinguished from other zinc fingers by three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif, which form a compact phosphatidylinositol 3-phosphate (PtdIns3P, also termed PI3P)-binding site. They are found in many membrane trafficking regulators, including EEA1, Hrs, Vac1p, Vps27p, and FENS-1, which locate to early endosomes, specifically bind PtdIns3P, and play important roles in vesicular traffic and in signal transduction. Some proteins, such as rabphilin-3A and alpha-Rab3-interacting molecules (RIMs), are also involved in membrane trafficking and bind to members of the Rab subfamily of GTP hydrolases. However, they contain FYVE-related domains that are structurally similar to the canonical FYVE domains but lack the three signature sequences. At this point, they may not bind to phosphoinositides. In addition, this superfamily also contains the third group of proteins, caspase-associated ring proteins CARP1 and CARP2. They do not localize to membranes in the cell and are involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8 and caspase 10, which are distinguished from other FYVE-type proteins. Moreover, these proteins have an altered sequence in the basic ligand binding patch and lack the WxxD motif that is conserved only in phosphoinositide binding FYVE domains. Thus they constitute a family of unique FYVE-type domains called FYVE-like domains. The FYVE domain is structurally similar to the RING domain and the PHD finger. This superfamily also includes ADDz zinc finger domain, which is a PHD-like zinc finger motif that contains two parts, a C2-C2 and a PHD-like zinc finger.
Pssm-ID: 277249 [Multi-domain] Cd Length: 52 Bit Score: 86.05 E-value: 1.58e-20
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 767975501 1399 NCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK--KPVRVCDACF 1448
Cdd:cd00065 1 RCMLCGKKFSLFRRRHHCRRCGRVFCSKCSSKKLPLPSFGsgKPVRVCDSCY 52
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
285-1006 |
8.58e-20 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 96.28 E-value: 8.58e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 285 ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLtenllkkeqdytkle 364
Cdd:TIGR02168 243 ELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL--------------- 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 365 ekhneeSVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 444
Cdd:TIGR02168 308 ------RERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQL 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 445 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDK-EQQVADLQLKLSRLEEQLKEKVTNSTELQH 523
Cdd:TIGR02168 382 ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLeEAELKELQAELEELEEELEELQEELERLEE 461
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 524 QLDKTKQQHqeqqalqqsttAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED-------LYAKIQ 596
Cdd:TIGR02168 462 ALEELREEL-----------EEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsgilgvLSELIS 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 597 AGEG-ETAVLNQLQEKNHTL----QEQVTQLTEKLKNQ-----------SESHKQAQENLHDQVQEQKAHLRAAQDRV-- 658
Cdd:TIGR02168 531 VDEGyEAAIEAALGGRLQAVvvenLNAAKKAIAFLKQNelgrvtflpldSIKGTEIQGNDREILKNIEGFLGVAKDLVkf 610
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 659 -----------LSLETSVNELNSQLNESKEKVSQLDIQIKAKTelLLSAEAAKTAQRADlqnhldtAQNALQDKQQELNK 727
Cdd:TIGR02168 611 dpklrkalsylLGGVLVVDDLDNALELAKKLRPGYRIVTLDGD--LVRPGGVITGGSAK-------TNSSILERRREIEE 681
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 728 ITTQLDQVTAKLQdkqehcsQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 807
Cdd:TIGR02168 682 LEEKIEELEEKIA-------ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSK 754
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 808 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQEtkiqHEELNNRIQTTVTELQKVK 887
Cdd:TIGR02168 755 ELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE----LTLLNEEAANLRERLESLE 830
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 888 MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTcKELKHQLQVQMENTLKEQKELKKSLEKEKEA 967
Cdd:TIGR02168 831 RRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSEELRELESK 909
|
730 740 750
....*....|....*....|....*....|....*....
gi 767975501 968 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL 1006
Cdd:TIGR02168 910 RSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEE 948
|
|
| FYVE_WDFY3 |
cd15719 |
FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar ... |
1391-1451 |
2.90e-19 |
|
FYVE domain found in WD40 repeat and FYVE domain-containing protein 3 (WDFY3) and similar proteins; WDFY3, also termed autophagy-linked FYVE protein (Alfy), is a ubiquitously expressed phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding protein required for selective macroautophagic degradation of aggregated proteins. It regulates the protein degradation through the direct interaction with the autophagy protein Atg5. Moreover, WDFY3 acts as a scaffold that bridges its cargo to the macroautophagic machinery via the creation of a greater complex with Atg12, Atg16L, and LC3. It also functionally associates with sequestosome-1/p62 (SQSTM1) in osteoclasts. WDFY3 shuttles between the nucleus and cytoplasm. It predominantly localizes to the nucleus and nuclear membrane under basal conditions, but is recruited to cytoplasmic ubiquitin-positive protein aggregates under stress conditions. WDFY3 contains a PH-BEACH domain assemblage, five WD40 repeats and a PtdIns3P-binding FYVE domain.
Pssm-ID: 277259 [Multi-domain] Cd Length: 65 Bit Score: 82.82 E-value: 2.90e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK--KPVRVCDACFNDL 1451
Cdd:cd15719 3 WVKDEGGDSCTGCSVRFSLTERRHHCRNCGQLFCSKCSRFESEIRRLRisRPVRVCQACYNIL 65
|
|
| FYVE_ANFY1 |
cd15728 |
FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar ... |
1391-1451 |
7.09e-19 |
|
FYVE domain found in ankyrin repeat and FYVE domain-containing protein 1 (ANFY1) and similar proteins; ANFY1, also termed ankyrin repeats hooked to a zinc finger motif (Ankhzn), is a novel cytoplasmic protein that belongs to a new group of double zinc finger proteins involved in vesicle or protein transport. It is ubiquitously expressed in a spatiotemporal-specific manner and is located on endosomes. ANFY1 contains an N-terminal coiled-coil region and a BTB/POZ domain, ankyrin repeats in the middle, and a C-terminal FYVE domain.
Pssm-ID: 277267 [Multi-domain] Cd Length: 63 Bit Score: 81.70 E-value: 7.09e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 1391 WAEDNevqNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKnaLTPSSK----KPVRVCDACFNDL 1451
Cdd:cd15728 4 WADGD---YCYECGVKFGITTRKHHCRHCGRLLCSKCSTK--EVPIIKfdlnKPVRVCDVCFDVL 63
|
|
| FYVE_RUFY1 |
cd15758 |
FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; ... |
1391-1451 |
7.59e-19 |
|
FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins; RUFY1, also termed FYVE-finger protein EIP1, or La-binding protein 1, or Rab4-interacting protein (Rabip4), or Zinc finger FYVE domain-containing protein 12 (ZFY12), a human homologue of mouse Rabip4, an effector of Rab4 GTPase that regulates recycling of endocytosed cargo. RUFY1 is an endosomal protein that functions as a dual effector of Rab4 and Rab14 and is involved in efficient recycling of transferrin (Tfn). It is a downstream effector of Etk, a downstream tyrosine kinase of PI3-kinase that is involved in regulation of vesicle trafficking. RUFY1 contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between.
Pssm-ID: 277297 [Multi-domain] Cd Length: 71 Bit Score: 82.04 E-value: 7.59e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDL 1451
Cdd:cd15758 6 WLKDDEATHCKQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLL 66
|
|
| FYVE_Hrs |
cd15720 |
FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) ... |
1391-1451 |
1.02e-18 |
|
FYVE domain found in hepatocyte growth factor (HGF)-regulated tyrosine kinase substrate (Hrs) and similar proteins; Hrs, also termed protein pp110, is a tyrosine phosphorylated protein that plays an important role in the signaling pathway of HGF. It is localized to early endosomes and an essential component of the endosomal sorting and trafficking machinery. Hrs interacts with hypertonia-associated protein Trak1, a novel regulator of endosome-to-lysosome trafficking. It can also forms an Hrs/actinin-4/BERP/myosin V protein complex that is required for efficient transferrin receptor (TfR) recycling but not for epidermal growth factor receptor (EGFR) degradation. Moreover, Hrs, together with STAM proteins, STAM1 and STAM2, and EPs15, forms a multivalent ubiquitin-binding complex that sorts ubiquitinated proteins into the multivesicular body pathway, and plays a regulatory role in endocytosis/exocytosis. Furthermore, Hrs functions as an interactor of the neurofibromatosis 2 tumor suppressor protein schwannomin/merlin. It is also involved in the inhibition of citron kinase-mediated HIV-1 budding. Hrs contains a single ubiquitin-interacting motif (UIM) that is crucial for its function in receptor sorting, and a FYVE domain that harbors double Zn2+ binding sites.
Pssm-ID: 277260 [Multi-domain] Cd Length: 61 Bit Score: 81.28 E-value: 1.02e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1391 WAEDNEvqnCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSS--KKPVRVCDACFNDL 1451
Cdd:cd15720 2 WKDGDE---CHRCRVQFGVFQRKHHCRACGQVFCGKCSSKSSTIPKFgiEKEVRVCDPCYEKL 61
|
|
| FYVE_scVPS27p_like |
cd15760 |
FYVE domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 27 ... |
1390-1448 |
1.13e-18 |
|
FYVE domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 27 (scVps27p) and similar proteins; scVps27p, also termed Golgi retention defective protein 11, is the putative yeast counterpart of the mammalian protein Hrs and is involved in endosome maturation. It is a mono-ubiquitin-binding protein that interacts with ubiquitinated cargoes, such as Hse1p, and is required for protein sorting into the multivesicular body. Vps27p forms a complex with Hse1p. The complex binds ubiquitin and mediates endosomal protein sorting. At the endosome, Vps27p and a trimeric protein complex, ESCRT-1, bind ubiquitin and are important for multivesicular body (MVB) sorting. Vps27p contains an N-terminal VHS (Vps27/Hrs/STAM) domain, a FYVE domain that binds PtdIns3P, followed by two ubiquitin-interacting motifs (UIMs), and a C-terminal clathrin-binding motif.
Pssm-ID: 277299 [Multi-domain] Cd Length: 59 Bit Score: 81.19 E-value: 1.13e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1390 KWAEDNEvqnCMACGKGFSVTVRRHHCRQCGNIFCAECSAK----NALTPSSkKPVRVCDACF 1448
Cdd:cd15760 1 HWKPDSR---CDVCRKKFGLFKRRHHCRNCGDSFCSEHSSRriplPHLGPLG-VPQRVCDRCF 59
|
|
| FYVE_endofin |
cd15729 |
FYVE domain found in endofin and similar proteins; Endofin, also termed zinc finger FYVE ... |
1391-1451 |
1.64e-18 |
|
FYVE domain found in endofin and similar proteins; Endofin, also termed zinc finger FYVE domain-containing protein 16 (ZFY16), or endosome-associated FYVE domain protein, is a FYVE domain-containing protein that is localized to EEA1-containing endosomes. It is regulated by phosphoinositol lipid and engaged in endosome-mediated receptor modulation. Endofin is involved in Bone morphogenetic protein (BMP) signaling through interacting with Smad1 preferentially and enhancing Smad1 phosphorylation and nuclear localization upon BMP stimulation. It also functions as a scaffold protein that brings Smad4 to the proximity of the receptor complex in Transforming growth factor (TGF)-beta signaling. Moreover, endofin is a novel tyrosine phosphorylation target downstream of epidermal growth factor receptor (EGFR) in EGF-signaling. In addition, endofin plays a role in endosomal trafficking by recruiting cytosolic TOM1, an important molecule for membrane recruitment of clathrin, onto endosomal membranes.
Pssm-ID: 277268 [Multi-domain] Cd Length: 68 Bit Score: 80.86 E-value: 1.64e-18
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAE-CSAKNALTPSSKKPVRVCDACFNDL 1451
Cdd:cd15729 7 WVPDSEAPNCMQCEVKFTFTKRRHHCRACGKVLCSAcCSLKARLEYLDNKEARVCVPCYQTL 68
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
179-978 |
1.83e-18 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 92.04 E-value: 1.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 179 LQSLEQQLEEAQTEnfnIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ 258
Cdd:TIGR02168 202 LKSLERQAEKAERY---KELKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSE 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 259 RPgiEDVAVLKKELVQVQTLMDNMTLERERESEKLKDeckkLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 338
Cdd:TIGR02168 279 LE--EEIEELQKELYALANEISRLEQQKQILRERLAN----LERQLEELEAQLEELESKLDELAEELAELEEKLEELKEE 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 339 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEES--VSKKNIQATLHQKDLdcQQLQSRLSASETSLHRIHVELSEKGEAT 416
Cdd:TIGR02168 353 LESLEAELEELEAELEELESRLEELEEQLETLRskVAQLELQIASLNNEI--ERLEARLERLEDRRERLQQEIEELLKKL 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 417 QKLkeELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK--EQRQLSSEKLMDKE 494
Cdd:TIGR02168 431 EEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDslERLQENLEGFSEGV 508
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 495 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK-----LREAQNDLEQVLRQIGDKDQKIQN 569
Cdd:TIGR02168 509 KALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQAVVVENLNAAKkaiafLKQNELGRVTFLPLDSIKGTEIQG 588
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 570 LEALLQKSKEN----ISLLEKEREDLYAKIQAGEGETAVLNQLQE-----KNHTLQEQVTQLTEKLKNQSESHKQAQENL 640
Cdd:TIGR02168 589 NDREILKNIEGflgvAKDLVKFDPKLRKALSYLLGGVLVVDDLDNalelaKKLRPGYRIVTLDGDLVRPGGVITGGSAKT 668
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 641 HDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 720
Cdd:TIGR02168 669 NSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEER 748
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 721 KQQELNKITTQLDQVTAKLQDKQEhcsqLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 800
Cdd:TIGR02168 749 IAQLSKELTELEAEIEELEERLEE----AEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE 824
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 801 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEkkilkqdfetlsqetkiqHEELNNRIQTTV 880
Cdd:TIGR02168 825 RLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESE------------------LEALLNERASLE 886
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 881 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 960
Cdd:TIGR02168 887 EALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDD 966
|
810
....*....|....*...
gi 767975501 961 LEKEKEASHQLKLELNSM 978
Cdd:TIGR02168 967 EEEARRRLKRLENKIKEL 984
|
|
| FYVE_MTMR4 |
cd15733 |
FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins; MTMR4, also ... |
1391-1448 |
1.67e-17 |
|
FYVE domain found in myotubularin-related protein 4 (MTMR4) and similar proteins; MTMR4, also termed FYVE domain-containing dual specificity protein phosphatase 2 (FYVE-DSP2), or zinc finger FYVE domain-containing protein 11, is an dual specificity protein phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P or PI3P). It is localizes to early endosomes, as well as to Rab11- and Sec15-positive recycling endosomes, and regulates sorting from early endosomes. Moreover, MTMR4 is preferentially associated with and dephosphorylated the activated regulatory Smad proteins (R-Smads) in cytoplasm to keep transforming growth factor (TGF) beta signaling in homeostasis. It also functions as an essential negative modulator for the homeostasis of bone morphogenetic protein (BMP)/decapentaplegic (Dpp) signaling. In addition, MTMR4 acts as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4) and may play a role in the biological process of muscle breakdown. MTMR4 contains an N-terminal PH-GRAM (PH-G) domain, a MTM phosphatase domain, a coiled-coil region, and a C-terminal FYVE domain.
Pssm-ID: 277272 [Multi-domain] Cd Length: 60 Bit Score: 77.86 E-value: 1.67e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK--KPVRVCDACF 1448
Cdd:cd15733 1 WVPDHAASHCFGCDCEFWLAKRKHHCRNCGNVFCADCSNYKLPIPDEQlyDPVRVCNSCY 60
|
|
| FYVE_PKHF2 |
cd15755 |
FYVE domain found in protein containing both PH and FYVE domains 2 (phafin-2) and similar ... |
1391-1451 |
4.69e-17 |
|
FYVE domain found in protein containing both PH and FYVE domains 2 (phafin-2) and similar proteins; Phafin-2, also termed endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains (EAPF), or pleckstrin homology domain-containing family F member 2 (PKHF2), or PH domain-containing family F member 2, or PH and FYVE domain-containing protein 2, or zinc finger FYVE domain-containing protein 18, is a ubiquitously expressed endoplasmic reticulum-associated protein that facilitates tumor necrosis factor alpha (TNF-alpha)-triggered cellular apoptosis through endoplasmic reticulum (ER)-mitochondrial apoptotic pathway. It is an endosomal phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) effector, as well as an interactor of the endosomal-tethering protein EEA1. It regulates endosome fusion upstream of Rab5. Phafin-2 also functions as a novel regulator of endocytic epidermal growth factor receptor (EGFR) degradation through a role in endosomal fusion.
Pssm-ID: 277294 [Multi-domain] Cd Length: 64 Bit Score: 76.61 E-value: 4.69e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1391 WAEDNEVQNCMACGKG-FSVTVRRHHCRQCGNIFCAECSAKNALTPS-SKKPVRVCDACFNDL 1451
Cdd:cd15755 2 WVPDSEATVCMRCQKAkFTPVNRRHHCRKCGFVVCGPCSEKKFLLPSqSSKPVRVCDFCYDLL 64
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
285-850 |
8.31e-17 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 86.53 E-value: 8.31e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 285 ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE 364
Cdd:COG1196 222 LKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLE 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 365 EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 444
Cdd:COG1196 302 QDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEEL 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 445 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEklmdKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 524
Cdd:COG1196 382 EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE----LEEALAELEEEEEEEEEALEEAAEEEAELEEE 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 525 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 604
Cdd:COG1196 458 EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYE 537
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 605 LNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSqlneskekVSQLDI 684
Cdd:COG1196 538 AALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDL--------VASDLR 609
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 685 QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLE 764
Cdd:COG1196 610 EADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLA 689
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 765 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 844
Cdd:COG1196 690 EEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELEREL 769
|
....*.
gi 767975501 845 TKQEEE 850
Cdd:COG1196 770 ERLERE 775
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
156-953 |
1.28e-16 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 86.26 E-value: 1.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 156 EKYQGLQQQEAKPDGLVtdSSAELQSLEQQLEEAQTEnfnIKQMKDLFEQKAAQLATeiadIKSKYDEERSLREAAEQKV 235
Cdd:TIGR02168 213 ERYKELKAELRELELAL--LVLRLEELREELEELQEE---LKEAEEELEELTAELQE----LEEKLEELRLEVSELEEEI 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 236 TRLTEELNKEATVIQDLKTELlqrpgiedvAVLKKELVQVQTLMDnmtlERERESEKLKDECKKLQSQYASSEATISQLR 315
Cdd:TIGR02168 284 EELQKELYALANEISRLEQQK---------QILRERLANLERQLE----ELEAQLEELESKLDELAEELAELEEKLEELK 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 316 SELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAtlHQKDLDCQQLQSRL 395
Cdd:TIGR02168 351 EELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLED--RRERLQQEIEELLK 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 396 SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS------------ 463
Cdd:TIGR02168 429 KLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERlqenlegfsegv 508
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 464 -KLLETERQLGEAHGRLKEQrqLSSEK-----------------LMDKEQQVADLQlklSRLEEQLKEKVTN---STELQ 522
Cdd:TIGR02168 509 kALLKNQSGLSGILGVLSEL--ISVDEgyeaaieaalggrlqavVVENLNAAKKAI---AFLKQNELGRVTFlplDSIKG 583
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 523 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLR-------------------------------------------- 558
Cdd:TIGR02168 584 TEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnalelakklrpgyrivtldgdlvrpggvitg 663
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 559 -------QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEgetavlNQLQEKNHTLQEQVTQLTEkLKNQSE 631
Cdd:TIGR02168 664 gsaktnsSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELE------EELEQLRKELEELSRQISA-LRKDLA 736
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 632 SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHl 711
Cdd:TIGR02168 737 RLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL- 815
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 712 dtaQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 791
Cdd:TIGR02168 816 ---NEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALL 892
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 792 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTkqeEEKKILKQDFETLSQETKIQHEE 871
Cdd:TIGR02168 893 RSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLS---EEYSLTLEEAEALENKIEDDEEE 969
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 872 LNNRI---QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKenqkgkaAILDLEKTCKELKHQLQVQME 948
Cdd:TIGR02168 970 ARRRLkrlENKIKELGPVNLAAIEEYEELKERYDFLTAQKEDLTEAKETLEE-------AIEEIDREARERFKDTFDQVN 1042
|
....*
gi 767975501 949 NTLKE 953
Cdd:TIGR02168 1043 ENFQR 1047
|
|
| FYVE_MTMR3 |
cd15732 |
FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins; MTMR3, also ... |
1390-1448 |
1.58e-16 |
|
FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins; MTMR3, also termed Myotubularin-related phosphatase 3, or FYVE domain-containing dual specificity protein phosphatase 1 (FYVE-DSP1), or zinc finger FYVE domain-containing protein 10, is a ubiquitously expressed phosphoinositide 3-phosphatase specific for phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and PIKfyve, which produces PtdIns(3,5)P2 from PtdIns3P. It regulates cell migration through modulating phosphatidylinositol 5-phosphate (PtdIns5P) levels. MTMR3 contains an N-terminal PH-GRAM (PH-G) domain, a MTM phosphatase domain, a coiled-coil region, and a C-terminal FYVE domain. Unlike conventional FYVE domains, the FYVE domain of MTMR3 neither confers endosomal localization nor binds to PtdIns3P. It is also not required for the enzyme activity of MTMR3. In contrast, the PH-G domain binds phosphoinositides.
Pssm-ID: 277271 [Multi-domain] Cd Length: 61 Bit Score: 74.94 E-value: 1.58e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1390 KWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSK--KPVRVCDACF 1448
Cdd:cd15732 1 RWVPDHLAASCYGCEREFWLASRKHHCRNCGNVFCGSCCNQKLPVPSQQlfEPSRVCKSCF 61
|
|
| FYVE_ZF21 |
cd15727 |
FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins; ... |
1391-1447 |
3.89e-16 |
|
FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins; ZF21 is phosphoinositide-binding protein that functions as a regulator of focal adhesions and cell movement through interaction with focal adhesion kinase. It can also bind to the cytoplasmic tail of membrane type 1 matrix metalloproteinase, a potent invasion-promoting protease, and play a key role in regulating multiple aspects of cancer cell migration and invasion. ZF21 contains a FYVE domain, which corresponds to this model.
Pssm-ID: 277266 [Multi-domain] Cd Length: 64 Bit Score: 73.95 E-value: 3.89e-16
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTP--SSKKPVRVCDAC 1447
Cdd:cd15727 4 WVPDKECPVCMSCKKKFDFFKRRHHCRRCGKCFCSDCCSNKVPLPrmCFVDPVRVCNEC 62
|
|
| FYVE_FGD6 |
cd15743 |
FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar ... |
1391-1448 |
4.65e-16 |
|
FYVE domain found in FYVE, RhoGEF and PH domain-containing protein 6 (FGD6) and similar proteins; FGD6, also termed zinc finger FYVE domain-containing protein 24 is a putative Cdc42-specific guanine nucleotide exchange factor (GEF) whose biological function remains unclear. It is a homologue of FGD1 and contains a DBL homology (DH) domain and pleckstrin homology (PH) domain in the middle region, a FYVE domain, and another PH domain in the C-terminus, but lacks the N-terminal proline-rich domain (PRD) found in FGD1. Moreover, the FYVE domain of FGD6 is a canonical FYVE domain, which has been found in many proteins involved in membrane trafficking and phosphoinositide metabolism, and has been defined by three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCR patch, and a C-terminal RVC motif, which form a compact phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding site.
Pssm-ID: 277282 [Multi-domain] Cd Length: 61 Bit Score: 73.63 E-value: 4.65e-16
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNA-LTPSSKKPVRVCDACF 1448
Cdd:cd15743 3 WIPDSRVTMCMICTSEFTVTWRRHHCRACGKVVCGSCSSNKApLEYLKNKSARVCDECF 61
|
|
| FYVE_RABE_unchar |
cd15739 |
FYVE domain found in uncharacterized rab GTPase-binding effector proteins from bilateria; This ... |
1390-1448 |
6.46e-16 |
|
FYVE domain found in uncharacterized rab GTPase-binding effector proteins from bilateria; This family includes a group of uncharacterized rab GTPase-binding effector proteins found in bilateria. Although their biological functions remain unclear, they all contain a FYVE domain that harbors a putative phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding site.
Pssm-ID: 277278 [Multi-domain] Cd Length: 73 Bit Score: 73.53 E-value: 6.46e-16
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1390 KWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACF 1448
Cdd:cd15739 3 RWQHEDDVDQCPNCKTPFSVGKRKHHCRHCGKIFCSDCLTKTVPSGPNRRPARVCDVCH 61
|
|
| FYVE_FYCO1 |
cd15726 |
FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar ... |
1391-1448 |
8.11e-16 |
|
FYVE domain found in FYVE and coiled-coil domain-containing protein 1 (FYCO1) and similar proteins; FYCO1, also termed zinc finger FYVE domain-containing protein 7, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that is associated with the exterior of autophagosomes and mediates microtubule plus-end-directed vesicle transport. It acts as an effector of GTP-bound Rab7, a GTPase that recruits FYCO1 to autophagosomes and has been implicated in autophagosome-lysosomal fusion. FYCO1 also interacts with two microtubule motor proteins, kinesin (KIF) 5B and KIF23, and thus functions as a platform for assembly of vesicle fusion and trafficking factors. FYCO1 contains an N-terminal alpha-helical RUN domain followed by a long central coiled-coil region, a FYVE domain and a GOLD (Golgi dynamics) domain in C-terminus.
Pssm-ID: 277265 [Multi-domain] Cd Length: 58 Bit Score: 72.98 E-value: 8.11e-16
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACF 1448
Cdd:cd15726 1 WQDDTDVTHCLDCKSEFSWMVRRHHCRLCGRIFCYACSNFYVLTAHGGKKERCCKACF 58
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
309-1053 |
8.19e-16 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 83.58 E-value: 8.19e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 309 ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN---------LLKKEQDYTKLEEKHNEESV--SKKNI 377
Cdd:TIGR02169 163 AGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRErekaeryqaLLKEKREYEGYELLKEKEALerQKEAI 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 378 QATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKL-KEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 456
Cdd:TIGR02169 243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEE 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 457 EINQLHS---KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQqhq 533
Cdd:TIGR02169 323 RLAKLEAeidKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKR--- 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 534 eqqalqqsttaKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGEtavLNQLQEKNH 613
Cdd:TIGR02169 400 -----------EINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWK---LEQLAADLS 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 614 TLQEQVTQLTEKLKNQSESHKQAQENLhdqvQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLdIQIKAKTELL 693
Cdd:TIGR02169 466 KYEQELYDLKEEYDRVEKELSKLQREL----AEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQL-GSVGERYATA 540
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 694 LSAEAAKTAQRADLQNHLDTAQ------------------NALQDKQQELNKITTQ------LDQV-------------- 735
Cdd:TIGR02169 541 IEVAAGNRLNNVVVEDDAVAKEaiellkrrkagratflplNKMRDERRDLSILSEDgvigfaVDLVefdpkyepafkyvf 620
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 736 ----------TAKLQDKQEHCSQLESHL---------------------KEYKEKYLSLEQKTEELEGQIKKLEADSLEV 784
Cdd:TIGR02169 621 gdtlvvedieAARRLMGKYRMVTLEGELfeksgamtggsraprggilfsRSEPAELQRLRERLEGLKRELSSLQSELRRI 700
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 785 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETL-SQ 863
Cdd:TIGR02169 701 ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLeEA 780
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 864 ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSdslkNSKSEFEKENQKGKAAILDLEKTCKELKhql 943
Cdd:TIGR02169 781 LNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLT----LEKEYLEKEIQELQEQRIDLKEQIKSIE--- 853
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 944 qvqmentlKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 1023
Cdd:TIGR02169 854 --------KEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAK 925
|
810 820 830
....*....|....*....|....*....|
gi 767975501 1024 LKIAVLQKTELENKLQQQLTQAAQELAAEK 1053
Cdd:TIGR02169 926 LEALEEELSEIEDPKGEDEEIPEEELSLED 955
|
|
| FYVE_FGD1_2_4 |
cd15741 |
FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia ... |
1390-1451 |
1.37e-15 |
|
FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4; This family represents a group of Rho GTPase cell division cycle 42 (Cdc42)-specific guanine nucleotide exchange factors (GEFs), including FYVE, RhoGEF and PH domain-containing protein FGD1, FGD2 and FGD4. FGD1, also termed faciogenital dysplasia 1 protein, or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF), or zinc finger FYVE domain-containing protein 3, is a central regulator of extracellular matrix remodeling and belongs to the DBL family of GEFs that regulate the activation of the Rho GTPases. FGD1 is encoded by gene FGD1. Disabling mutations in the FGD1 gene cause the human X-linked developmental disorder faciogenital dysplasia (FGDY, also known as Aarskog-Scott syndrome). FGD2, also termed zinc finger FYVE domain-containing protein 4, is expressed in antigen-presenting cells, including B lymphocytes, macrophages, and dendritic cells. It localizes to early endosomes and active membrane ruffles. It plays a role in leukocyte signaling and vesicle trafficking in cells specialized to present antigen in the immune system. FGD4, also termed actin filament-binding protein frabin, or FGD1-related F-actin-binding protein, or zinc finger FYVE domain-containing protein 6, functions as an F-actin-binding (FAB) protein showing significant homology to FGD1. It induces the formation of filopodia through the activation of Cdc42 in fibroblasts. Those FGD proteins possess a similar domain organization that contains a DBL homology (DH) domain, a pleckstrin homology (PH) domain, a FYVE domain, and another PH domain in the C-terminus. However, each FGD has a unique N-terminal region that may directly or indirectly interact with F-actin. FGD1 and FGD4 have an N-terminal proline-rich domain (PRD) and an N-terminal F-actin binding (FAB) domain, respectively. This model corresponds to the FYVE domain, which has been found in many proteins involved in membrane trafficking and phosphoinositide metabolism, and has been defined by three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCR patch, and a C-terminal RVC motif, which form a compact phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding site. FGD1 possesses a FYVE-like domain that lack the N-terminal WxxD motif. Moreover, FGD2 is the only known RhoGEF family member shown to have a functional FYVE domain and endosomal binding activity.
Pssm-ID: 277280 [Multi-domain] Cd Length: 65 Bit Score: 72.52 E-value: 1.37e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767975501 1390 KWAEDNEVQNCMACGKGF-SVTVRRHHCRQCGNIFCAECSAKNA-LTPSSKKPVRVCDACFNDL 1451
Cdd:cd15741 2 RWVRDNEVTMCMRCKEPFnALTRRRHHCRACGYVVCWKCSDYKAtLEYDGNKLNRVCKHCYVIL 65
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
544-1340 |
1.81e-15 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 82.42 E-value: 1.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 544 AKLREAQNDLEQVLRQIGDKD----QKIQNLEAL------------LQKSKENI--SLLEKEREDLYAKIQAGEGE---- 601
Cdd:TIGR02169 170 RKKEKALEELEEVEENIERLDliidEKRQQLERLrrerekaeryqaLLKEKREYegYELLKEKEALERQKEAIERQlasl 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 602 TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRvlsLETSVNELNSQLNESKEKVSQ 681
Cdd:TIGR02169 250 EEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIAS---LERSIAEKERELEDAEERLAK 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 682 LDIQIKAKTELLLSAEAAKTAQRADLqnhlDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 761
Cdd:TIGR02169 327 LEAEIDKLLAEIEELEREIEEERKRR----DKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREIN 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 762 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLqqqrqlnTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 841
Cdd:TIGR02169 403 ELKRELDRLQEELQRLSEELADLNAAIAGIEAKI-------NELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLK 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 842 QKLTKQEEEKKILKQDFETL----------SQETKIQHEELNNRIQ---TTVTELQKVKmEKEALMTElSTVKDKLSKV- 907
Cdd:TIGR02169 476 EEYDRVEKELSKLQRELAEAeaqaraseerVRGGRAVEEVLKASIQgvhGTVAQLGSVG-ERYATAIE-VAAGNRLNNVv 553
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 908 --SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK------------------EKEA 967
Cdd:TIGR02169 554 veDDAVAKEAIELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKyepafkyvfgdtlvvediEAAR 633
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 968 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN---KLQQQLTQ 1044
Cdd:TIGR02169 634 RLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENrldELSQELSD 713
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1045 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGN-----QNKLI 1119
Cdd:TIGR02169 714 ASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDlearlSHSRI 793
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1120 QELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEikcrQEKEITKLNEELKSHKLESIKE 1199
Cdd:TIGR02169 794 PEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKE----QIKSIEKEIENLNGKKEELEEE 869
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1200 ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAkLHSEIKEKEVGMKKHEEnea 1279
Cdd:TIGR02169 870 LEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEA-LEEELSEIEDPKGEDEE--- 945
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 1280 kltmqITALNENLGTVKKEWQSSQRRVSELE--------------KQTDDLRGEIAVLEAtvqnnqdERRALLER 1340
Cdd:TIGR02169 946 -----IPEEELSLEDVQAELQRVEEEIRALEpvnmlaiqeyeevlKRLDELKEKRAKLEE-------ERKAILER 1008
|
|
| FYVE_RBNS5 |
cd15716 |
FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and ... |
1391-1451 |
2.14e-15 |
|
FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins; Rbsn-5, also termed zinc finger FYVE domain-containing protein 20, is a novel Rab5 effector that is complexed to the Sec1-like protein VPS45 and recruited in a phosphatidylinositol-3-kinase-dependent fashion to early endosomes. It also binds to Rab4 and EHD1/RME-1, two regulators of the recycling route, and is involved in cargo recycling to the plasma membrane. Moreover, Rbsn-5 regulates endocytosis at the apical side of the wing epithelium and plays a role of the apical endocytic trafficking of Fmi in the establishment of planar cell polarity (PCP).
Pssm-ID: 277256 [Multi-domain] Cd Length: 61 Bit Score: 71.99 E-value: 2.14e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALtpsskkPVRVCDACFNDL 1451
Cdd:cd15716 4 WVNDSDVPFCPDCGKKFNLARRRHHCRLCGSIMCNKCSQFLPL------HIRCCHHCKDLL 58
|
|
| FYVE_ZFY26 |
cd15724 |
FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26); ZFY26, also termed ... |
1391-1449 |
5.00e-15 |
|
FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26); ZFY26, also termed FYVE domain-containing centrosomal protein (FYVE-CENT), or spastizin, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding protein that localizes to the centrosome and midbody. ZFY26 and its interacting partners TTC19 and KIF13A are required for cytokinesis. It also interacts with Beclin 1, a subunit of class III phosphatidylinositol 3-kinase complex, and may have potential implications for carcinogenesis. In addition, it has been considered as the causal agent of a rare form of hereditary spastic paraplegia. ZFY26 contains a FYVE domain that is important for targeting of FYVE-CENT to the midbody.
Pssm-ID: 277263 [Multi-domain] Cd Length: 61 Bit Score: 70.62 E-value: 5.00e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1391 WAEDNEVQNCMAC-GKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKK-PVRVCDACFN 1449
Cdd:cd15724 1 WVPDEAVSVCMVCqVERFSMFNRRHHCRRCGRVVCSSCSTKKMLVEGYREnPVRVCDQCYE 61
|
|
| FYVE_PKHF1 |
cd15754 |
FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1) and similar ... |
1391-1451 |
5.34e-15 |
|
FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1) and similar proteins; Phafin-1, also termed lysosome-associated apoptosis-inducing protein containing PH (pleckstrin homology) and FYVE domains (LAPF), or pleckstrin homology domain-containing family F member 1 (PKHF1), or PH domain-containing family F member 1, or apoptosis-inducing protein, or PH and FYVE domain-containing protein 1, or zinc finger FYVE domain-containing protein 15, is a representative of a novel family of PH and FYVE domain-containing proteins called phafins. It is a ubiquitously expressed pro-apoptotic protein via translocating to lysosomes, facilitating apoptosis induction through a lysosomal-mitochondrial apoptotic pathway.
Pssm-ID: 277293 [Multi-domain] Cd Length: 64 Bit Score: 70.76 E-value: 5.34e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1391 WAEDNEVQNCMACGK-GFSVTVRRHHCRQCGNIFCAECSAKNALTPS-SKKPVRVCDACFNDL 1451
Cdd:cd15754 2 WIPDKATDICMRCTQtNFSLLTRRHHCRKCGFVVCHECSRQRFLIPRlSPKPVRVCSLCYRKL 64
|
|
| FYVE_spVPS27p_like |
cd15735 |
FYVE domain found in Schizosaccharomyces pombe vacuolar protein sorting-associated protein 27 ... |
1394-1448 |
5.49e-15 |
|
FYVE domain found in Schizosaccharomyces pombe vacuolar protein sorting-associated protein 27 (spVps27p) and similar proteins; spVps27p, also termed suppressor of ste12 deletion protein 4 (Sst4p), is a conserved homolog of budding Saccharomyces cerevisiae Vps27 and of mammalian Hrs. It functions as a downstream factor for phosphatidylinositol 3-kinase (PtdIns 3-kinase) in forespore membrane formation with normal morphology. It colocalizes and interacts with Hse1p, a homolog of Saccharomyces cerevisiae Hse1p and of mammalian STAM, to form a complex whose ubiquitin-interacting motifs (UIMs) are important for sporulation. spVps27p contains a VHS (Vps27p/Hrs/Stam) domain, a FYVE domain, and two UIMs.
Pssm-ID: 277274 [Multi-domain] Cd Length: 59 Bit Score: 70.64 E-value: 5.49e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 1394 DNEVqnCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTP--SSKKPVRVCDACF 1448
Cdd:cd15735 5 DSDV--CMRCRTAFTFTNRKHHCRNCGGVFCQQCSSKSLPLPhfGINQPVRVCDGCY 59
|
|
| FYVE_ZFYV1 |
cd15734 |
FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar ... |
1391-1448 |
5.79e-15 |
|
FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins; ZFYV1, also termed double FYVE-containing protein 1 (DFCP1), or SR3, or tandem FYVE fingers-1, is a novel tandem FYVE domain containing protein that binds phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) with high specificity over other phosphoinositides. The subcellular distribution of exogenously-expressed ZFYV1 to Golgi, endoplasmic reticulum (ER) and vesicular is governed in part by its FYVE domains but unaffected by wortmannin, a PI3-kinase inhibitor. In addition to C-terminal tandem FYVE domain, ZFYV1 contains an N-terminal putative C2H2 type zinc finger and a possible nucleotide binding P-loop.
Pssm-ID: 277273 [Multi-domain] Cd Length: 61 Bit Score: 70.44 E-value: 5.79e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSS--KKPVRVCDACF 1448
Cdd:cd15734 2 WVPDSEIKECSVCKRPFSPRLSKHHCRACGQGVCDDCSKNRRPVPSRgwDHPVRVCDPCA 61
|
|
| FYVE_RUFY2 |
cd15759 |
FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; ... |
1391-1447 |
9.13e-15 |
|
FYVE domain found in RUN and FYVE domain-containing protein 2 (RUFY2) and similar proteins; RUFY2, also termed Rab4-interacting protein related, is a novel embryonic factor that contains an N-terminal RUN domain and a C-terminal FYVE domain with two coiled-coil domains in-between. It is present in the nucleus at early stages of embryonic development. It may have both endosomal functions in the cytoplasm and nuclear functions.
Pssm-ID: 277298 [Multi-domain] Cd Length: 71 Bit Score: 70.44 E-value: 9.13e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDAC 1447
Cdd:cd15759 4 WLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSPKPVRVCDSC 60
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
930-1233 |
3.01e-14 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 78.05 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 930 LDLEKTCKELKHQLQV-QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 1008
Cdd:COG1196 216 RELKEELKELEAELLLlKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1009 SSEQKKKQIEALQGELKIAVLQKTELEnklqQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATR 1088
Cdd:COG1196 296 ELARLEQDIARLEERRRELEERLEELE----EELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1089 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1168
Cdd:COG1196 372 AELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 1169 AEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQ---LLIQQKLELQGKADSLKAAVEQEKR 1233
Cdd:COG1196 452 AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAArllLLLEAEADYEGFLEGVKAALLLAGL 519
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
156-719 |
3.36e-14 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 78.05 E-value: 3.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 156 EKYQGLQQQEAKPDGLVT-----DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 230
Cdd:COG1196 213 ERYRELKEELKELEAELLllklrELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYE 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 231 AEQKVTRLTEELNKEATVIQDLKTELLQRpgIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL---QSQYASS 307
Cdd:COG1196 293 LLAELARLEQDIARLEERRRELEERLEEL--EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELaeaEEALLEA 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 308 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLD 387
Cdd:COG1196 371 EAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEE 450
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 388 CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREE-KEQHGLQLQSEINQLHSKLL 466
Cdd:COG1196 451 EAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGvKAALLLAGLRGLAGAVAVLI 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 467 ----ETERQLGEAHGRLKEQRQLSSEKLMdKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQST 542
Cdd:COG1196 531 gveaAYEAALEAALAAALQNIVVEDDEVA-AAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLR 609
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 543 TAKLREAQNDLEQVLRQIgdkdqkiqnLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL 622
Cdd:COG1196 610 EADARYYVLGDTLLGRTL---------VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAE 680
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 623 TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTA 702
Cdd:COG1196 681 LEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPP 760
|
570
....*....|....*..
gi 767975501 703 QRADLQNHLDTAQNALQ 719
Cdd:COG1196 761 DLEELERELERLEREIE 777
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
116-981 |
8.77e-14 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 76.65 E-value: 8.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 116 GESNLALKRDDvtlLRQEVQDLQASLKEEKWysEELKKELEKYQG----LQQQEAKPDGLVTDSSAELQSLEQQLEEAQt 191
Cdd:TIGR02169 205 REREKAERYQA---LLKEKREYEGYELLKEK--EALERQKEAIERqlasLEEELEKLTEEISELEKRLEEIEQLLEELN- 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 192 enfniKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKtellqrpgiEDVAVLKKE 271
Cdd:TIGR02169 279 -----KKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLL---------AEIEELERE 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 272 LVQVQTLMDNMTlereRESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 351
Cdd:TIGR02169 345 IEEERKRRDKLT----EEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSE 420
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 352 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKyq 431
Cdd:TIGR02169 421 ELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQ-- 498
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 432 hlkaefkqlQQQREEKEQHGLQLQSEINQLHSKLLETERQLgeahGRLKEQRQLSSEKLMDKEQQ--VADLQLKLSRLEE 509
Cdd:TIGR02169 499 ---------ARASEERVRGGRAVEEVLKASIQGVHGTVAQL----GSVGERYATAIEVAAGNRLNnvVVEDDAVAKEAIE 565
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 510 QLKEKVTNSTELqhqLDKTKQQHQEQQALQQSTTAKLREAQNdleqvlrqIGDKDQKIQNLEALLQKSKENISLLEKERE 589
Cdd:TIGR02169 566 LLKRRKAGRATF---LPLNKMRDERRDLSILSEDGVIGFAVD--------LVEFDPKYEPAFKYVFGDTLVVEDIEAARR 634
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 590 DL-YAKIQAGEGEtavlnqLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEnLHDQVQEQKAHLRAAQDRVLSLETSVNEL 668
Cdd:TIGR02169 635 LMgKYRMVTLEGE------LFEKSGAMTGGSRAPRGGILFSRSEPAELQR-LRERLEGLKRELSSLQSELRRIENRLDEL 707
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 669 NSQLNESKEKVSQLDIQIkaktELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQ 748
Cdd:TIGR02169 708 SQELSDASRKIGEIEKEI----EQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALND 783
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 749 LESHLKEykEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRL 828
Cdd:TIGR02169 784 LEARLSH--SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNG 861
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 829 DLQKKSEALESIKQKLTKQEEEKKILKQDFEtlsqETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 908
Cdd:TIGR02169 862 KKEELEEELEELEAALRDLESRLGDLKKERD----ELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIE 937
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 909 DSLKNSKSEFEKEnqkgkAAILDLEKTCKELKHQLQV----------QMENTLKEQKELKKSLEKEKEASHQLKLELNSM 978
Cdd:TIGR02169 938 DPKGEDEEIPEEE-----LSLEDVQAELQRVEEEIRAlepvnmlaiqEYEEVLKRLDELKEKRAKLEEERKAILERIEEY 1012
|
...
gi 767975501 979 QEQ 981
Cdd:TIGR02169 1013 EKK 1015
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
130-789 |
1.45e-13 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 76.25 E-value: 1.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 130 LRQEVQDLQASLKEEKWYSEELKKELEKYQG----LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQ 205
Cdd:TIGR02168 258 LTAELQELEEKLEELRLEVSELEEEIEELQKelyaLANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAE 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 206 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRpgIEDVAVLKKELVQVQTLMDNMTLE 285
Cdd:TIGR02168 338 ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQL--ELQIASLNNEIERLEARLERLEDR 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 286 RERESEKLKDECKKLQS-QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLE 364
Cdd:TIGR02168 416 RERLQQEIEELLKKLEEaELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE 495
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 365 ---EKHNEESVSKKNIQATLHQKDLDCQQLQSRLS-------ASETSL-HRIHVELSEKGEATQKLKEELSEVET----- 428
Cdd:TIGR02168 496 rlqENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyeaAIEAALgGRLQAVVVENLNAAKKAIAFLKQNELgrvtf 575
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 429 ------KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL----------------LETERQLGE------AHGRLK 480
Cdd:TIGR02168 576 lpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALsyllggvlvvddldnaLELAKKLRPgyrivtLDGDLV 655
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 481 EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLK-------EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL 553
Cdd:TIGR02168 656 RPGGVITGGSAKTNSSILERRREIEELEEKIEeleekiaELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDL 735
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 554 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGEtavLNQLQEKNHTLQEQVTQLTEKLKNQSESH 633
Cdd:TIGR02168 736 ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE---IEELEAQIEQLKEELKALREALDELRAEL 812
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 634 KQAQENLHDQVQEQKAHLRaaqdRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLlsaeAAKTAQRADLQNHLDT 713
Cdd:TIGR02168 813 TLLNEEAANLRERLESLER----RIAATERRLEDLEEQIEELSEDIESLAAEIEELEELI----EELESELEALLNERAS 884
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 714 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKE 789
Cdd:TIGR02168 885 LEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALE 960
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
488-1362 |
1.57e-13 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 75.87 E-value: 1.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 488 EKLMDKEQQVADLQLKLSRLEEQLKekvTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 567
Cdd:TIGR02169 177 EELEEVEENIERLDLIIDEKRQQLE---RLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEEL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 568 QNLEALLQKSKENISLLEKEREDLYAKIQA-GEGETavlNQLQEKNHTLQEQVtqltEKLKNQSESHKQAQENLHDQVQE 646
Cdd:TIGR02169 254 EKLTEEISELEKRLEEIEQLLEELNKKIKDlGEEEQ---LRVKEKIGELEAEI----ASLERSIAEKERELEDAEERLAK 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 647 QKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLdiqiKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 726
Cdd:TIGR02169 327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAEL----KEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREIN 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 727 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAdslevkaskeqalqdlqqqrqlntdle 806
Cdd:TIGR02169 403 ELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEW--------------------------- 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 807 lRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILkqdfETLSQETKIQHEELNNRIQT---TVTEL 883
Cdd:TIGR02169 456 -KLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARAS----EERVRGGRAVEEVLKASIQGvhgTVAQL 530
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 884 QKVKmEKEALMTElSTVKDKLSKV---SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 960
Cdd:TIGR02169 531 GSVG-ERYATAIE-VAAGNRLNNVvveDDAVAKEAIELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEF 608
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 961 LEK------------------EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 1022
Cdd:TIGR02169 609 DPKyepafkyvfgdtlvvediEAARRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKR 688
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1023 ELKIAVLQKTELENklqqQLTQAAQELAAEKEKISVLQNNYEKSQEtfkqlqsdfygresELLATRQDLKSVEEKLSLAQ 1102
Cdd:TIGR02169 689 ELSSLQSELRRIEN----RLDELSQELSDASRKIGEIEKEIEQLEQ--------------EEEKLKERLEELEEDLSSLE 750
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1103 EDlisnrnqignqnklIQELKTAKATLEQDSAKKEQQLQERCKALQDIqkEKSLKEKELVNEKSKLAEIEEIKCRQEKEI 1182
Cdd:TIGR02169 751 QE--------------IENVKSELKELEARIEELEEDLHKLEEALNDL--EARLSHSRIPEIQAELSKLEEEVSRIEARL 814
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1183 TKLNEELKSHKLEsiKEItnLKDAKQLLIQQKLELQGKADSLKAAVEQEKrnqqilkdqvkkeeeelkkefiEKEAKLHS 1262
Cdd:TIGR02169 815 REIEQKLNRLTLE--KEY--LEKEIQELQEQRIDLKEQIKSIEKEIENLN----------------------GKKEELEE 868
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1263 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVkkewqssQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1342
Cdd:TIGR02169 869 ELEELEAALRDLESRLGDLKKERDELEAQLREL-------ERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKG 941
|
890 900
....*....|....*....|....*.
gi 767975501 1343 KGEGE------IEKLQTKVLELQRKL 1362
Cdd:TIGR02169 942 EDEEIpeeelsLEDVQAELQRVEEEI 967
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
417-1200 |
1.67e-13 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 75.87 E-value: 1.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 417 QKLKEELSEVETKYQHLKAEFKQLQQQREekeqhglQLQSEINQ-LHSKLLETERQLGEAHGRLKEQRQLSSEKlMDKEQ 495
Cdd:TIGR02169 173 EKALEELEEVEENIERLDLIIDEKRQQLE-------RLRREREKaERYQALLKEKREYEGYELLKEKEALERQK-EAIER 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 496 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDK-TKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL 574
Cdd:TIGR02169 245 QLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERL 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 575 QKSKENISLLEKEREDLYAKIQagegetavlnqlqeknhTLQEQVTQLTEKLKNQseshKQAQENLHDQVQEQKAHLRAA 654
Cdd:TIGR02169 325 AKLEAEIDKLLAEIEELEREIE-----------------EERKRRDKLTEEYAEL----KEELEDLRAELEEVDKEFAET 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 655 QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLqNHLDTaqnALQDKQQELNKITTQLDQ 734
Cdd:TIGR02169 384 RDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKI-NELEE---EKEDKALEIKKQEWKLEQ 459
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 735 VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK 814
Cdd:TIGR02169 460 LAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERYAT 539
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 815 QLEME-----KEIVSSTRLDLQKKSEALESIKQ------KLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVT-- 881
Cdd:TIGR02169 540 AIEVAagnrlNNVVVEDDAVAKEAIELLKRRKAgratflPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEPAFKyv 619
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 882 ----------ELQKVKMEKEALMTELSTVKDKL-SKVSDSLKNSKSEFEKENQKGKAAildlektckelkhQLQVQMENT 950
Cdd:TIGR02169 620 fgdtlvvediEAARRLMGKYRMVTLEGELFEKSgAMTGGSRAPRGGILFSRSEPAELQ-------------RLRERLEGL 686
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 951 LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK--IAV 1028
Cdd:TIGR02169 687 KRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKelEAR 766
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1029 LQKTELEnKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN 1108
Cdd:TIGR02169 767 IEELEED-LHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDL 845
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1109 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIeEIKCRQEKEITKLNEE 1188
Cdd:TIGR02169 846 KEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEEL-EAQIEKKRKRLSELKA 924
|
810
....*....|..
gi 767975501 1189 LKSHKLESIKEI 1200
Cdd:TIGR02169 925 KLEALEEELSEI 936
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
738-1397 |
4.55e-13 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 74.32 E-value: 4.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 738 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTE------ELEGQIKKLEADSLevKASKEQALQDLQQQRQLNTDLELRATE 811
Cdd:TIGR02168 180 KLERTRENLDRLEDILNELERQLKSLERQAEkaerykELKAELRELELALL--VLRLEELREELEELQEELKEAEEELEE 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 812 LSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLtkqeEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 891
Cdd:TIGR02168 258 LTAELQELEEKLEELRLEVSELEEEIEELQKEL----YALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 892 ALMTELSTVKDKLskvsDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQvQMENTLKEQKELKKSLEKEKEASHQL 971
Cdd:TIGR02168 334 ELAEELAELEEKL----EELKEELESLEAELEELEAELEELESRLEELEEQLE-TLRSKVAQLELQIASLNNEIERLEAR 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 972 KLELNSMQEQLIQAQNTL--KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAqEL 1049
Cdd:TIGR02168 409 LERLEDRRERLQQEIEELlkKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELA-QL 487
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1050 AAEKEKISVLQNNYEKSQETFKQL---QSDFYGreseLLATRQDLKSVEEKLSLAQE-DLISNRNQIGNQNKliQELKTA 1125
Cdd:TIGR02168 488 QARLDSLERLQENLEGFSEGVKALlknQSGLSG----ILGVLSELISVDEGYEAAIEaALGGRLQAVVVENL--NAAKKA 561
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1126 KATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLneelkshkLESIKEITNLKD 1205
Cdd:TIGR02168 562 IAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYL--------LGGVLVVDDLDN 633
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1206 AKQLLIQQKLE-----LQGKADSLKAAV--EQEKRNQQIL-KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1277
Cdd:TIGR02168 634 ALELAKKLRPGyrivtLDGDLVRPGGVItgGSAKTNSSILeRRREIEELEEKIEELEEKIAELEKALAELRKELEELEEE 713
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1278 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLE 1357
Cdd:TIGR02168 714 LEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ 793
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 767975501 1358 LQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEV 1397
Cdd:TIGR02168 794 LKEELKALREALDELRAELTLLNEEAANLRERLESLERRI 833
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
758-1340 |
5.12e-13 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 74.20 E-value: 5.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 758 EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATElsKQLEMEKEIVSSTRLDLQKKSEAL 837
Cdd:COG1196 213 ERYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE--AELEELRLELEELELELEEAQAEE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 838 ESIKQKLTKQEEEKKILK---QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 914
Cdd:COG1196 291 YELLAELARLEQDIARLEerrRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 915 KSEFEKENqkgkaaildlektckELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 994
Cdd:COG1196 371 EAELAEAE---------------EELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEE 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 995 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1074
Cdd:COG1196 436 EEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALL 515
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1075 SDFYGRESELLATRQDLKSVEEKL---SLAQEDLISNRNQIGNQNKLIQELKTAK---ATLEQDSAKKEQQLQERCKALQ 1148
Cdd:COG1196 516 LAGLRGLAGAVAVLIGVEAAYEAAleaALAAALQNIVVEDDEVAAAAIEYLKAAKagrATFLPLDKIRARAALAAALARG 595
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1149 DIQKEKSLKEKELVNEKSKLAEIEEIKcrQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1228
Cdd:COG1196 596 AIGAAVDLVASDLREADARYYVLGDTL--LGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAA 673
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1229 EQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENlgtvkkewqssQRRVSE 1308
Cdd:COG1196 674 LLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREE-----------LLEELL 742
|
570 580 590
....*....|....*....|....*....|..
gi 767975501 1309 LEKQTDDLRGEIAVLEATVQNNQDERRALLER 1340
Cdd:COG1196 743 EEEELLEEEALEELPEPPDLEELERELERLER 774
|
|
| FYVE_PIKfyve_Fab1 |
cd15725 |
FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins; PIKfyve, ... |
1391-1448 |
9.02e-13 |
|
FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins; PIKfyve, also termed FYVE finger-containing phosphoinositide kinase, or 1-phosphatidylinositol 3-phosphate 5-kinase, or phosphatidylinositol 3-phosphate 5-kinase (PIP5K3), or phosphatidylinositol 3-phosphate 5-kinase type III (PIPkin-III or type III PIP kinase), is a phosphoinositide 5-kinase that forms a complex with its regulators, the scaffolding protein Vac14 and the lipid phosphatase Fig4. The complex is responsible for synthesizing phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2] from phosphatidylinositol 3-phosphate (PtdIns3P or PI3P). Then phosphatidylinositol-5-phosphate (PtdIns5P) is generated directly from PtdIns(3,5)P2. PtdIns(3,5)P2 and PtdIns5P regulate endosomal trafficking and responses to extracellular stimuli. At this point, PIKfyve is vital in early embryonic development. Moreover, PIKfyve forms a complex with ArPIKfyve (associated regulator of PIKfyve) and SAC3 at the endomembranes, which plays a role in receptor tyrosine kinase (RTK) degradation. The phosphorylation of PIKfyve by AKT can facilitate Epidermal growth factor receptor (EGFR) degradation. In addition, PIKfyve may participate in the regulation of the glutamate transporters EAAT2, EAAT3 and EAAT4, and the cystic fibrosis transmembrane conductance regulator (CFTR). It is also essential for systemic glucose homeostasis and insulin-regulated glucose uptake/GLUT4 translocation in skeletal muscle. It can be activated by protein kinase B (PKB/Akt) and further up-regulates human ether-a-go-go (hERG) channels. This family also includes the yeast and plant orthologs of human PIKfyve, Fab1. PIKfyve and its orthologs share a similar architecture. They contain an N-terminal FYVE domain, a middle region related to the CCT/TCP-1/Cpn60 chaperonins that are involved in productive folding of actin and tubulin, a second middle domain that contains a number of conserved cysteine residues (CCR) unique to this family, and a C-terminal lipid kinase domain related to PtdInsP kinases.
Pssm-ID: 277264 [Multi-domain] Cd Length: 62 Bit Score: 64.27 E-value: 9.02e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKP--VRVCDACF 1448
Cdd:cd15725 2 WMPDSSCKECYECSEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFIGYPgdLRVCTYCC 61
|
|
| FYVE_MTMR_unchar |
cd15738 |
FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from ... |
1390-1448 |
1.20e-12 |
|
FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa; This family includes a group of uncharacterized myotubularin-related proteins mainly found in eumetazoa. Although their biological functions remain unclear, they share similar domain architecture that consists of an N-terminal pleckstrin homology (PH) domain, a highly conserved region related to myotubularin proteins, a C-terminal FYVE domain. The model corresponds to the FYVE domain, which resembles the FYVE-related domain as it has an altered sequence in the basic ligand binding patch.
Pssm-ID: 277277 [Multi-domain] Cd Length: 61 Bit Score: 63.89 E-value: 1.20e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1390 KWAEDNEVQNCmACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPS--SKKPVRVCDACF 1448
Cdd:cd15738 2 DWKSFRNVTEC-SCSTPFDHFSKKHHCWRCGNVFCTRCIDKQRALPGhlSQRPVPVCRACY 61
|
|
| FYVE_FGD5 |
cd15742 |
FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar ... |
1397-1452 |
1.41e-12 |
|
FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins; FGD5, also termed zinc finger FYVE domain-containing protein 23, is an endothelial cell (EC)-specific guanine nucleotide exchange factor (GEF) that regulates endothelial adhesion, survival, and angiogenesis by modulating phosphatidylinositol 3-kinase signaling. It functions as a novel genetic regulator of vascular pruning by activation of endothelial cell-targeted apoptosis. FGD5 is a homologue of FGD1 and contains a DBL homology (DH) domain, a pleckstrin homology (PH) domain, a FYVE domain, and another PH domain in the C-terminus, but lacks the N-terminal proline-rich domain (PRD) found in FGD1. The FYVE domain of FGD5 resembles a FYVE-like domain that is different from the canonical FYVE domains, since it lacks one of the three conserved signature motifs (the WxxD motif) that are involved in phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding and exhibits altered lipid binding specificities.
Pssm-ID: 277281 [Multi-domain] Cd Length: 67 Bit Score: 64.19 E-value: 1.41e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 1397 VQNCMACGKGFSVTVRRHHCRQCGNIFCAECSA-KNALTPSSKKPVRVCDACFNDLQ 1452
Cdd:cd15742 9 VMMCMNCGSDFTLTLRRHHCHACGKIVCRNCSRnKYPLKYLKDRPAKVCDGCFAELR 65
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
671-1382 |
1.53e-12 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 72.79 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 671 QLNESKEKVSQLDIQIKAKTELL--LSAEAAKTAQRADLQNHLDTAQNALqdKQQELNKITTQLDQVTAKLQDKQEHCSQ 748
Cdd:TIGR02169 178 ELEEVEENIERLDLIIDEKRQQLerLRREREKAERYQALLKEKREYEGYE--LLKEKEALERQKEAIERQLASLEEELEK 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 749 LESHLKEYKEKYLSLEQKTEELEGQIKKL-EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTR 827
Cdd:TIGR02169 256 LTEEISELEKRLEEIEQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLL 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 828 LDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETkiqhEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 907
Cdd:TIGR02169 336 AEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAEL----EEVDKEFAETRDELKDYREKLEKLKREINELKRELDRL 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 908 SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKhQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQN 987
Cdd:TIGR02169 412 QEELQRLSEELADLNAAIAGIEAKINELEEEKE-DKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQR 490
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 988 TLKQNEKEEQQLQ---------------------GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL-------- 1038
Cdd:TIGR02169 491 ELAEAEAQARASEervrggraveevlkasiqgvhGTVAQLGSVGERYATAIEVAAGNRLNNVVVEDDAVAKEaiellkrr 570
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1039 -----------QQQLTQAAQELAAEKEKISVLQNNYE---KSQETFKQLQSDFYGRESELLATRQDLK--------SVEE 1096
Cdd:TIGR02169 571 kagratflplnKMRDERRDLSILSEDGVIGFAVDLVEfdpKYEPAFKYVFGDTLVVEDIEAARRLMGKyrmvtlegELFE 650
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1097 KLSLAQEDLISNRNQIGNQNKL----------IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKelvneks 1166
Cdd:TIGR02169 651 KSGAMTGGSRAPRGGILFSRSEpaelqrlrerLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEK------- 723
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1167 klaEIEEIKCRQEKEITKLnEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQqilkdqvkkee 1246
Cdd:TIGR02169 724 ---EIEQLEQEEEKLKERL-EELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL----------- 788
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1247 eelkkefiekeakLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1326
Cdd:TIGR02169 789 -------------SHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKE 855
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 1327 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1382
Cdd:TIGR02169 856 IENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQ 911
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
263-1065 |
1.71e-12 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 72.41 E-value: 1.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 263 EDVAVLKKELVQVQTLMDNM-----TLERERE---------SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 328
Cdd:TIGR02169 177 EELEEVEENIERLDLIIDEKrqqleRLRREREkaeryqallKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 329 VQELQKLKSSVNELTQKNQTLTENLLKK-EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 407
Cdd:TIGR02169 257 TEEISELEKRLEEIEQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLA 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 408 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEahgrlkeqrqlss 487
Cdd:TIGR02169 337 EIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINE------------- 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 488 eklmdkeqqvadLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 567
Cdd:TIGR02169 404 ------------LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQEL 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 568 QNLEALLQKSKENISLLEKEREDLYAKIQAGE----GETAVLNQLQEKNHTLQEQVTQLTE---------------KLKN 628
Cdd:TIGR02169 472 YDLKEEYDRVEKELSKLQRELAEAEAQARASEervrGGRAVEEVLKASIQGVHGTVAQLGSvgeryataievaagnRLNN 551
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 629 ----QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN--------------------------ESKEK 678
Cdd:TIGR02169 552 vvveDDAVAKEAIELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGfavdlvefdpkyepafkyvfgdtlvvEDIEA 631
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 679 VSQLDIQIKAKT---ELLLSAEAAKTAQRADLQNHLDTAQnaLQDKQQELNKITTQLDQVTAKLQDKQEHcsqLESHLKE 755
Cdd:TIGR02169 632 ARRLMGKYRMVTlegELFEKSGAMTGGSRAPRGGILFSRS--EPAELQRLRERLEGLKRELSSLQSELRR---IENRLDE 706
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 756 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEmekeivsSTRLDLQKKSE 835
Cdd:TIGR02169 707 LSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIE-------ELEEDLHKLEE 779
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 836 ALESIKQKLTK---QEEEKKILKQDFETLSQETKIQH-EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL 911
Cdd:TIGR02169 780 ALNDLEARLSHsriPEIQAELSKLEEEVSRIEARLREiEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENL 859
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 912 KNSKSEFEKENQKGKAAILDLEKTCKELKHQ---LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 988
Cdd:TIGR02169 860 NGKKEELEEELEELEAALRDLESRLGDLKKErdeLEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDP 939
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 989 LKQnEKEEQQLQGNINELKQSSEQKKKQIEALqGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK 1065
Cdd:TIGR02169 940 KGE-DEEIPEEELSLEDVQAELQRVEEEIRAL-EPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEK 1014
|
|
| FYVE_scVPS27p_Vac1p_like |
cd15736 |
FYVE domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 27 ... |
1400-1448 |
1.85e-12 |
|
FYVE domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 27 (scVps27p) and FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; The family includes Saccharomyces cerevisiae vacuolar protein sorting-associated protein 27 (scVps27p) and protein VAC1 (Vac1p). scVps27p, also termed Golgi retention defective protein 11, is the putative yeast counterpart of the mammalian protein Hrs and is involved in endosome maturation. It is a mono-ubiquitin-binding protein that interacts with ubiquitinated cargoes, such as Hse1p, and is required for protein sorting into the multivesicular body. Vps27p forms a complex with Hse1p. The complex binds ubiquitin and mediates endosomal protein sorting. At the endosome, Vps27p and a trimeric protein complex, ESCRT-1, bind ubiquitin and are important for multivesicular body (MVB) sorting. Vps27p contains an N-terminal VHS (Vps27/Hrs/STAM) domain, a FYVE domain that binds PtdIns3P, followed by two ubiquitin-interacting motifs (UIMs), and a C-terminal clathrin-binding motif. Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The FYVE domain in both Vps27p and Vac1p harbors a zinc-binding site composed of seven Cysteines and one Histidine, which is different from that of other FYVE domain containing proteins.
Pssm-ID: 277275 [Multi-domain] Cd Length: 56 Bit Score: 63.36 E-value: 1.85e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 1400 CMACGKGFSVTVRRHHCRQCGNIFCAECSAKN------ALTPSSKKPVRVCDACF 1448
Cdd:cd15736 2 CHTCSRTFNLNIRAHHCRKCGKLFCRRHLPNMiplnlsAYDPRNGKWYRCCHSCF 56
|
|
| FYVE2_Vac1p_like |
cd15737 |
FYVE domain 2 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also termed ... |
1390-1447 |
2.12e-12 |
|
FYVE domain 2 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The family corresponds to the second FYVE domain that is responsible for the ability of Pep7p to efficiently interact with Vac1p and Vps45p.
Pssm-ID: 277276 [Multi-domain] Cd Length: 83 Bit Score: 64.06 E-value: 2.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1390 KWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCA----ECS--------------------AKNALTPSSKKPVRVCD 1445
Cdd:cd15737 1 PWEDDSSVTHCPICLRSFGLLLRKHHCRLCGKVVCDdrrtKCStevpldllssalpdlpfvfkEPQSDIPDDTKSVRVCR 80
|
..
gi 767975501 1446 AC 1447
Cdd:cd15737 81 DC 82
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
408-1290 |
2.21e-12 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 72.31 E-value: 2.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 408 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 487
Cdd:pfam02463 177 KLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESS 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 488 EKLMDKEQQVADLQLKLSRLEEQLKEkvtnstelqhqldKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKI 567
Cdd:pfam02463 257 KQEIEKEEEKLAQVLKENKEEEKEKK-------------LQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEK 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 568 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH------ 641
Cdd:pfam02463 324 KKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELelksee 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 642 -DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 720
Cdd:pfam02463 404 eKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQ 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 721 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIkkleADSLEVKASKEQALQDLQQQRQ 800
Cdd:pfam02463 484 EQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVA----VENYKVAISTAVIVEVSATADE 559
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 801 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELnnriqttv 880
Cdd:pfam02463 560 VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKD-------- 631
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 881 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 960
Cdd:pfam02463 632 TELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEE 711
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 961 LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ 1040
Cdd:pfam02463 712 LKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEE 791
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1041 QLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1120
Cdd:pfam02463 792 KEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQE 871
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1121 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE-IEEIKCRQEKEITKLNEELKSHKLESIKE 1199
Cdd:pfam02463 872 LLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEErIKEEAEILLKYEEEPEELLLEEADEKEKE 951
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1200 ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEA 1279
Cdd:pfam02463 952 ENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLELFVSINK 1031
|
890
....*....|.
gi 767975501 1280 KLTMQITALNE 1290
Cdd:pfam02463 1032 GWNKVFFYLEL 1042
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
422-1037 |
7.14e-12 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 70.05 E-value: 7.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 422 ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQ----------LSSEKLM 491
Cdd:TIGR04523 34 EEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDkinklnsdlsKINSEIK 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 492 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 571
Cdd:TIGR04523 114 NDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 572 ALLQKSKENISLLEKeredlyaKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHL 651
Cdd:TIGR04523 194 NKLLKLELLLSNLKK-------KIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIK 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 652 RAAQDRVLSLETS---VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK----------------------TAQRAD 706
Cdd:TIGR04523 267 KQLSEKQKELEQNnkkIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNqekkleeiqnqisqnnkiisqlNEQISQ 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 707 LQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 786
Cdd:TIGR04523 347 LKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEK 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 787 SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETK 866
Cdd:TIGR04523 427 EIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 867 iqheELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKaaILDLEKTCKELKHQlqvq 946
Cdd:TIGR04523 507 ----ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKE--IDEKNKEIEELKQT---- 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 947 MENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 1026
Cdd:TIGR04523 577 QKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKE 656
|
650
....*....|.
gi 767975501 1027 AVLQKTELENK 1037
Cdd:TIGR04523 657 IRNKWPEIIKK 667
|
|
| FYVE_WDFY1_like |
cd15718 |
FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and ... |
1391-1448 |
7.93e-12 |
|
FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins; This family includes WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2. WDFY1, also termed FYVE domain containing protein localized to endosomes-1 (FENS-1), or phosphoinositide-binding protein 1, or zinc finger FYVE domain-containing protein 17, is a novel single FYVE domain containing protein that binds phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) with high specificity over other phosphoinositides. WDFY1 to early endosomes requires an intact FYVE domain and is inhibited by wortmannin, a PI3-kinase inhibitor. WDFY2, also termed zinc finger FYVE domain-containing protein 22, or ProF (propeller-FYVE protein), is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding protein that is localized to a distinct subset of early endosomes close to the plasma membrane. It interacts preferentially with endogenous serine/threonine kinase Akt2, but not Akt1, and plays a specific role in modulating signaling through Akt downstream of the interaction of this kinase with the endosomal proteins APPL (adaptor protein containing PH domain, PTB domain, and leucine zipper motif). In addition to Akt, WDFY2 serves as a binding partner for protein kinase C, zeta (PRKCZ), and its substrate vesicle-associated membrane protein 2 (VAMP2), and is involved in vesicle cycling in various secretory pathways. Moreover, Silencing of WDFY2 by siRNA produces a strong inhibition of endocytosis. Both WDFY1 and WDFY2 contain a FYVE domain and multiple WD-40 repeats.
Pssm-ID: 277258 [Multi-domain] Cd Length: 70 Bit Score: 61.95 E-value: 7.93e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1391 WAEDNevqNCMACGKGF-----------SVTVRRHHCRQCGNIFCAECSAKNALTPSS--KKPVRVCDACF 1448
Cdd:cd15718 3 WAESD---NCQKCSRPFfwnfkqmwekkTLGVRQHHCRKCGKAVCDKCSSNRSTIPVMgfEFPVRVCNECY 70
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
119-779 |
8.29e-12 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 70.47 E-value: 8.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 119 NLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ-----------GLQQQEAKPDGLVTDSSAELQSLEQQLE 187
Cdd:TIGR02168 338 ELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEeqletlrskvaQLELQIASLNNEIERLEARLERLEDRRE 417
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 188 EAQTEnfNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELlqrpgiedvav 267
Cdd:TIGR02168 418 RLQQE--IEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAEREL----------- 484
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 268 lkKELVQVQTLMDNMTLERERESEKLKdECKKLQSQYASSEATISQLRS---------ELAKGPQEVAVYVQELQKLKSS 338
Cdd:TIGR02168 485 --AQLQARLDSLERLQENLEGFSEGVK-ALLKNQSGLSGILGVLSELISvdegyeaaiEAALGGRLQAVVVENLNAAKKA 561
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 339 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLhqkdLDCQQLQSRLSAS-ETSLHRIHV--ELSEKGEA 415
Cdd:TIGR02168 562 IAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVA----KDLVKFDPKLRKAlSYLLGGVLVvdDLDNALEL 637
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 416 TQKLKEELSEVETKYQHLKAEFKQLqQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE---KLMD 492
Cdd:TIGR02168 638 AKKLRPGYRIVTLDGDLVRPGGVIT-GGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEEleeELEQ 716
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 493 KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEA 572
Cdd:TIGR02168 717 LRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKE 796
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 573 LLQKSKENISLLEKEredlyakiqagegetavLNQLQEKNHTLQEQVtqltEKLKNQSESHKQAQENLHDQVQEQKAHLR 652
Cdd:TIGR02168 797 ELKALREALDELRAE-----------------LTLLNEEAANLRERL----ESLERRIAATERRLEDLEEQIEELSEDIE 855
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 653 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIkaktELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQL 732
Cdd:TIGR02168 856 SLAAEIEELEELIEELESELEALLNERASLEEAL----ALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRL 931
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 767975501 733 DQVTAKLQDKQEHCSQLES-HLKEYKEKYLSLEQKTEELEGQIKKLEA 779
Cdd:TIGR02168 932 EGLEVRIDNLQERLSEEYSlTLEEAEALENKIEDDEEEARRRLKRLEN 979
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
667-1339 |
1.40e-11 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 69.58 E-value: 1.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 667 ELNSQLNESKEKVSQLDIQ-IKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH 745
Cdd:COG1196 217 ELKEELKELEAELLLLKLReLEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 746 CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEqalqdlqqqrqlntdlelratELSKQLEMEKEIVSS 825
Cdd:COG1196 297 LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELE---------------------ELEEELEEAEEELEE 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 826 TRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETkiqhEELNNRIQTTVTELQKVKMEKEALMTELStvkdkls 905
Cdd:COG1196 356 AEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAA----AELAAQLEELEEAEEALLERLERLEEELE------- 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 906 kvsdslknsksefekenqkgkaaildlektckelkhQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQA 985
Cdd:COG1196 425 ------------------------------------ELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAEL 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 986 QNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQL------TQAAQELAAEKEKISVL 1059
Cdd:COG1196 469 LEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAvavligVEAAYEAALEAALAAAL 548
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1060 QNNYEKSQETFKQ----LQSDFYGRESELLATRQdlkSVEEKLSLAQEDLISNRNQIGNQNKLIQELktAKATLEQDSAK 1135
Cdd:COG1196 549 QNIVVEDDEVAAAaieyLKAAKAGRATFLPLDKI---RARAALAAALARGAIGAAVDLVASDLREAD--ARYYVLGDTLL 623
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1136 KEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL 1215
Cdd:COG1196 624 GRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEE 703
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1216 ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTmQITALNENLGTV 1295
Cdd:COG1196 704 EEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE-RLEREIEALGPV 782
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 767975501 1296 ----KKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQN-NQDERRALLE 1339
Cdd:COG1196 783 nllaIEEYEELEERYDFLSEQREDLEEARETLEEAIEEiDRETRERFLE 831
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
224-1036 |
8.50e-11 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 67.07 E-value: 8.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 224 ERSLREAAEQkVTRLTEELNKEATVIQDLKTELLQrpgieDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 303
Cdd:pfam15921 77 ERVLEEYSHQ-VKDLQRRLNESNELHEKQKFYLRQ-----SVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNT 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 304 YASSEATISqLRSELAKgpqEVAVYVQELQKLKSSVNELTQKNQTLTENLlkKEQDYTKLEEKHNEESVSKKN----IQA 379
Cdd:pfam15921 151 VHELEAAKC-LKEDMLE---DSNTQIEQLRKMMLSHEGVLQEIRSILVDF--EEASGKKIYEHDSMSTMHFRSlgsaISK 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 380 TLHQKDLDCQQLQSRLSASETSLH-------------------RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL 440
Cdd:pfam15921 225 ILRELDTEISYLKGRIFPVEDQLEalksesqnkielllqqhqdRIEQLISEHEVEITGLTEKASSARSQANSIQSQLEII 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 441 QQQREEKE----QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 516
Cdd:pfam15921 305 QEQARNQNsmymRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLA 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 517 NSTELQHQLDKTKQQHQEQQALQQSTTAKlreaqndLEQVLRQIGDKDQKIQNLEALLQKSKeniSLLEKEREDLYAKIQ 596
Cdd:pfam15921 385 DLHKREKELSLEKEQNKRLWDRDTGNSIT-------IDHLRRELDDRNMEVQRLEALLKAMK---SECQGQMERQMAAIQ 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 597 AgegetavlnqlqeKNHTLqEQVTQLTEKLknqsESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 676
Cdd:pfam15921 455 G-------------KNESL-EKVSSLTAQL----ESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATN 516
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 677 EKVSQLDIQIKAKTELLlsaeaaktaqradlqNHLDTAQNALQDKQQELNKITTQL---DQVTAKLQDKQEHCSQLeshL 753
Cdd:pfam15921 517 AEITKLRSRVDLKLQEL---------------QHLKNEGDHLRNVQTECEALKLQMaekDKVIEILRQQIENMTQL---V 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 754 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKqlemekeiVSSTRLdlqkk 833
Cdd:pfam15921 579 GQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLVN--------AGSERL----- 645
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 834 sEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELstvkdklskvsDSLKN 913
Cdd:pfam15921 646 -RAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSEL-----------EQTRN 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 914 SKSEFEKENQKGKAAILDLEKTCKELKHQLQVqMENTLKEQKELKKSLEKEKeasHQLKLELNSMQEQLIQAQNtlkqne 993
Cdd:pfam15921 714 TLKSMEGSDGHAMKVAMGMQKQITAKRGQIDA-LQSKIQFLEEAMTNANKEK---HFLKEEKNKLSQELSTVAT------ 783
|
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 767975501 994 kEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 1036
Cdd:pfam15921 784 -EKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQFAECQD 825
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
755-1312 |
1.31e-10 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 66.70 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 755 EYKEKYLSLEQKTEElegqiKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD-LQKK 833
Cdd:PTZ00121 1312 EEAKKADEAKKKAEE-----AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADaAKKK 1386
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 834 SEALESIKQKLTKQEEEKKilKQDFETLSQETKIQHEELNNRIQttvtelQKVKMEKEALMTELSTVKDKLSKVSDSLKN 913
Cdd:PTZ00121 1387 AEEKKKADEAKKKAEEDKK--KADELKKAAAAKKKADEAKKKAE------EKKKADEAKKKAEEAKKADEAKKKAEEAKK 1458
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 914 SKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE 993
Cdd:PTZ00121 1459 AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADE 1538
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 994 KEEQQLQGNINELKQSSEQKKKQiealqgELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1073
Cdd:PTZ00121 1539 AKKAEEKKKADELKKAEELKKAE------EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEA 1612
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1074 QsdfygRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDsAKKEQQLQERCKALQDIQKE 1153
Cdd:PTZ00121 1613 K-----KAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE-AKKAEEDKKKAEEAKKAEED 1686
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1154 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDA---KQLLIQQKLELQGKADSLKAAVEQ 1230
Cdd:PTZ00121 1687 EKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAeedKKKAEEAKKDEEEKKKIAHLKKEE 1766
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1231 EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1310
Cdd:PTZ00121 1767 EKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEA 1846
|
..
gi 767975501 1311 KQ 1312
Cdd:PTZ00121 1847 DA 1848
|
|
| FYVE_RUFY4 |
cd15745 |
FYVE-related domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar ... |
1400-1448 |
1.87e-10 |
|
FYVE-related domain found in RUN and FYVE domain-containing protein 4 (RUFY4) and similar proteins; RUFY4 belongs to the FUFY protein family which is characterized by the presence of an N-terminal RUN domain and a C-terminal FYVE domain. The FYVE domain of RUFY4 resembles the FYVE-related domain as it lacks the WxxD motif (x for any residue). The biological function of RUFY4 still remains unclear.
Pssm-ID: 277284 [Multi-domain] Cd Length: 52 Bit Score: 57.51 E-value: 1.87e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1400 CMACGKGFSVTVRRHHCRQCGNIFCAECSAKNAL--TPSSKKPVRVCDACF 1448
Cdd:cd15745 2 CAICAKAFSLFRRKYVCRLCGGVVCHSCSSEDLVlsVPDTCIYLRVCKTCY 52
|
|
| FYVE_FGD3 |
cd15740 |
FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar ... |
1394-1448 |
4.85e-10 |
|
FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) and similar proteins; FGD3, also termed zinc finger FYVE domain-containing protein 5, is a putative Cdc42-specific guanine nucleotide exchange factor (GEF) that undergoes the ubiquitin ligase SCFFWD1/beta-TrCP-mediated proteasomal degradation. It is a homologue of FGD1 and contains a DBL homology (DH) domain and pleckstrin homology (PH) domain in the middle region, a FYVE domain, and another PH domain in the C-terminus, but lacks the N-terminal proline-rich domain (PRD) found in FGD1. Due to this difference, FGD3 may play different roles from that of FGD1 to regulate cell morphology or motility. The FYVE domain of FGD3 resembles a FYVE-like domain that is different from the canonical FYVE domains, since it lacks one of the three conserved signature motifs (the WxxD motif) that are involved in phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding and exhibits altered lipid binding specificities.
Pssm-ID: 277279 [Multi-domain] Cd Length: 54 Bit Score: 56.55 E-value: 4.85e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 1394 DNEVQNCMACGKGF-SVTVRRHHCRQCGNIFCAECSaknALTPSSKKPVRVCDACF 1448
Cdd:cd15740 2 EKEKQTCKGCNESFnSITKRRHHCKQCGAVICGKCS---EFKDLASRHNRVCRDCF 54
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
268-751 |
6.36e-10 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 63.91 E-value: 6.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 268 LKKELVQVQTLMDNMTLERERESEKLKD------ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE 341
Cdd:PRK02224 211 LESELAELDEEIERYEEQREQARETRDEadevleEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 342 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQ--------------QLQSRLSASETSLHRIHV 407
Cdd:PRK02224 291 LEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQahneeaeslredadDLEERAEELREEAAELES 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 408 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSS 487
Cdd:PRK02224 371 ELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLE 450
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 488 E-----------------KLMDKEQQVADLQLKLSRLEEQLkEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQ 550
Cdd:PRK02224 451 AgkcpecgqpvegsphveTIEEDRERVEELEAELEDLEEEV-EEVEERLERAEDLVEAEDRIERLEERREDLEELIAERR 529
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 551 NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEkLKNQS 630
Cdd:PRK02224 530 ETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIAD-AEDEI 608
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 631 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNElnSQLNESKEKVSQLDIQIKAKTELLlsaeAAKTAQRADLQNH 710
Cdd:PRK02224 609 ERLREKREALAELNDERRERLAEKRERKRELEAEFDE--ARIEEAREDKERAEEYLEQVEEKL----DELREERDDLQAE 682
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 767975501 711 LDTAQNALqDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 751
Cdd:PRK02224 683 IGAVENEL-EELEELRERREALENRVEALEALYDEAEELES 722
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
997-1299 |
9.05e-10 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 63.42 E-value: 9.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 997 QQLQGNINELKQSSEQKKK------QIEALQGELKIAVLQKTELEnklqqqLTQAAQELAAEKEKISVLQNNYEKSQETF 1070
Cdd:COG1196 196 GELERQLEPLERQAEKAERyrelkeELKELEAELLLLKLRELEAE------LEELEAELEELEAELEELEAELAELEAEL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1071 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDI 1150
Cdd:COG1196 270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1151 QKEKSLKEKELVNEKSKLAEIEeikcRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1230
Cdd:COG1196 350 EEELEEAEAELAEAEEALLEAE----AELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE 425
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1231 EKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEW 1299
Cdd:COG1196 426 LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLL 494
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
414-631 |
1.71e-09 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 61.70 E-value: 1.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 414 EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE---QRQLSSEKL 490
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAElekEIAELRAEL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 491 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNL 570
Cdd:COG4942 100 EAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975501 571 EALLQKSKENISLLEKEREDLYAKIQAGEGETAV-LNQLQEKNHTLQEQVTQLTEKLKNQSE 631
Cdd:COG4942 180 LAELEEERAALEALKAERQKLLARLEKELAELAAeLAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
738-1316 |
1.75e-09 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 62.39 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 738 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKaskeqalqdlQQQRQLNTDLELRATELSKqLE 817
Cdd:PRK03918 159 DYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVL----------REINEISSELPELREELEK-LE 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 818 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFEtlsqETKIQHEELNNRIQTtVTELQKVKMEKEALMTEL 897
Cdd:PRK03918 228 KEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIE----ELKKEIEELEEKVKE-LKELKEKAEEYIKLSEFY 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 898 STVKDKLSKVSDSLKNSKSEFE------KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 971
Cdd:PRK03918 303 EEYLDELREIEKRLSRLEEEINgieeriKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLT 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 972 KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL-ENKLQQQLTQAAQELA 1050
Cdd:PRK03918 383 GLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELtEEHRKELLEEYTAELK 462
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1051 AEKEKISVLQNNYEKSQETFKQLQSdFYGRESELLATRQ---DLKSVEEKLSlaqedlISNRNQIGNQNKLIQELKTAKA 1127
Cdd:PRK03918 463 RIEKELKEIEEKERKLRKELRELEK-VLKKESELIKLKElaeQLKELEEKLK------KYNLEELEKKAEEYEKLKEKLI 535
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1128 TLEqdsaKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE-EIKCRQEKEITKLNEELKShkLESI-KEITNLKD 1205
Cdd:PRK03918 536 KLK----GEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLkELEELGFESVEELEERLKE--LEPFyNEYLELKD 609
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1206 AKQLLIQQKLELQGKADSLKAA---VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1282
Cdd:PRK03918 610 AEKELEREEKELKKLEEELDKAfeeLAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRR 689
|
570 580 590
....*....|....*....|....*....|....
gi 767975501 1283 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDL 1316
Cdd:PRK03918 690 EEIKKTLEKLKEELEEREKAKKELEKLEKALERV 723
|
|
| FYVE_protrudin |
cd15723 |
FYVE-related domain found in protrudin and similar proteins; Protrudin, also termed zinc ... |
1399-1447 |
2.07e-09 |
|
FYVE-related domain found in protrudin and similar proteins; Protrudin, also termed zinc finger FYVE domain-containing protein 27 (ZFY27 or ZFYVE27), is a FYVE domain-containing protein involved in transport of neuronal cargoes and implicated in the onset of hereditary spastic paraplegia (HSP). It is involved in neurite outgrowth through binding to spastin. Moreover, it functions as a key regulator of the Rab11-dependent membrane trafficking during neurite extension. It serves as an adaptor molecule that links its associated proteins, such as Rab11-GDP, VAP-A and -B, Surf4, and RTN3, to KIF5, a motor protein that mediates anterograde vesicular transport in neurons, and thus plays a key role in the maintenance of neuronal function. The FYVE domain of protrudin resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. In addition, unlike canonical FYVE domains that is located to early endosomes and specifically binds to phosphatidylinositol 3-phosphate (PtdIns3P or PI3P), the FYVE domain of protrudin is located to plasma membrane and preferentially binds phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2), and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). In addition to FYVE-related domain, protrudin also contains a Rab11-binding domain (RBD11), two hydrophobic domains, HP-1 and HP-2, an FFAT motif, and a coiled-coil domain.
Pssm-ID: 277262 [Multi-domain] Cd Length: 62 Bit Score: 54.81 E-value: 2.07e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 1399 NCMACGKGFSV-TVRRHHCRQCGNIFCAEC-------SAKNALTPSSKK-PVRVCDAC 1447
Cdd:cd15723 1 NCTGCGASFSVlLKKRRSCNNCGNAFCSRCcskkvprSVMGATAPAAQReTVFVCSGC 58
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
507-1193 |
2.13e-09 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 62.05 E-value: 2.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 507 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 586
Cdd:pfam05483 97 IEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEY 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 587 EREDL-YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 665
Cdd:pfam05483 177 EREETrQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKM 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 666 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK---TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK 742
Cdd:pfam05483 257 KDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKdhlTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQ 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 743 QEHCSQLESH----LKEYKEKYLSLEQ--KTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELratELSKQL 816
Cdd:pfam05483 337 MEELNKAKAAhsfvVTEFEATTCSLEEllRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVEL---EELKKI 413
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 817 EMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKealmTE 896
Cdd:pfam05483 414 LAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKN----IE 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 897 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELN 976
Cdd:pfam05483 490 LTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLD 569
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 977 SMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKiAVLQKTELENKL----QQQLTQAAQELAAE 1052
Cdd:pfam05483 570 KSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENK-ALKKKGSAENKQlnayEIKVNKLELELASA 648
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1053 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1132
Cdd:pfam05483 649 KQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELG 728
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1133 SAKKEQQLQERCKAlqDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1193
Cdd:pfam05483 729 LYKNKEQEQSSAKA--ALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKDKK 787
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
477-1085 |
2.25e-09 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 62.36 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 477 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVtnSTELQHQLDKTKQQHQEQQALQQSTTAK---LREAQNDL 553
Cdd:PRK02224 162 GKLEEYRERASDARLGVERVLSDQRGSLDQLKAQIEEKE--EKDLHERLNGLESELAELDEEIERYEEQreqARETRDEA 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 554 EQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQagEGETAVLNQLQEKNHTLQEqvtqlteklknqSESH 633
Cdd:PRK02224 240 DEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVR--DLRERLEELEEERDDLLAE------------AGLD 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 634 KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADlqnhLDT 713
Cdd:PRK02224 306 DADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREA----VED 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 714 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQ 793
Cdd:PRK02224 382 RREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECGQPV 461
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 794 DLQQQRQLNTDLELRATELSKQLEMEKEivssTRLDLQKKSEALESikqkLTKQEEEKKILKQDFETLSQETKIQHEELN 873
Cdd:PRK02224 462 EGSPHVETIEEDRERVEELEAELEDLEE----EVEEVEERLERAED----LVEAEDRIERLEERREDLEELIAERRETIE 533
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 874 NRiQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK---------TCKELKHQLQ 944
Cdd:PRK02224 534 EK-RERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERirtllaaiaDAEDEIERLR 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 945 VQMENTLKEQKELKKSLEKEKEASHQLKLELNsmQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 1024
Cdd:PRK02224 613 EKREALAELNDERRERLAEKRERKRELEAEFD--EARIEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENEL 690
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1025 KiavlqktELENklqqqLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1085
Cdd:PRK02224 691 E-------ELEE-----LRERREALENRVEALEALYDEAEELESMYGDLRAELRQRNVETL 739
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
806-1399 |
3.38e-09 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 62.08 E-value: 3.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 806 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQK 885
Cdd:PTZ00121 1198 DARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEA 1277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 886 VKMEkealmtELSTVKDKlsKVSDSLKNSKSEFEKENQKGKAailDLEKTCKELKHQlqvqMENTLKEQKELKKSLEKEK 965
Cdd:PTZ00121 1278 RKAD------ELKKAEEK--KKADEAKKAEEKKKADEAKKKA---EEAKKADEAKKK----AEEAKKKADAAKKKAEEAK 1342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 966 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQgelKIAVLQKTELENKLQQQLTQA 1045
Cdd:PTZ00121 1343 KAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK---KAEEDKKKADELKKAAAAKKK 1419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1046 AQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES----ELLATRQDLKSVEEKLSLAQEDLISN--RNQIGNQNKLI 1119
Cdd:PTZ00121 1420 ADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAkkaeEAKKKAEEAKKADEAKKKAEEAKKADeaKKKAEEAKKKA 1499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1120 QEL-KTAKATLEQDSAKK--EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLES 1196
Cdd:PTZ00121 1500 DEAkKAAEAKKKADEAKKaeEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA 1579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1197 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEaKLHSEIKEKEVGMKKHEE 1276
Cdd:PTZ00121 1580 LRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKK-KEAEEKKKAEELKKAEEE 1658
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1277 NEAKLTMQitalnenlgtvKKEWQSSQRRVSELEKQTDDLRGEiavlEATVQNNQDERRALLERCLKGEGEIEKLQtkvl 1356
Cdd:PTZ00121 1659 NKIKAAEE-----------AKKAEEDKKKAEEAKKAEEDEKKA----AEALKKEAEEAKKAEELKKKEAEEKKKAE---- 1719
|
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 767975501 1357 ELQRKLDNTTAAVQELGRENQSlQIKHTQALNRKWAEDNEVQN 1399
Cdd:PTZ00121 1720 ELKKAEEENKIKAEEAKKEAEE-DKKKAEEAKKDEEEKKKIAH 1761
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
117-622 |
3.45e-09 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 61.49 E-value: 3.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 117 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG----LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE 192
Cdd:COG1196 245 EAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAeeyeLLAELARLEQDIARLEERRRELEERLEELEEE 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 193 NFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRpgIEDVAVLKKEL 272
Cdd:COG1196 325 LAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA--LRAAAELAAQL 402
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 273 VQVQTLMDNMTLERER-----------------ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL 335
Cdd:COG1196 403 EELEEAEEALLERLERleeeleeleealaeleeEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAEL 482
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 336 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEA 415
Cdd:COG1196 483 LEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAA 562
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 416 TQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG---------LQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLS 486
Cdd:COG1196 563 IEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGaavdlvasdLREADARYYVLGDTLLGRTLVAARLEAALRRAVTL 642
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 487 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDL-EQVLRQIGDKDQ 565
Cdd:COG1196 643 AGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELaEAEEERLEEELE 722
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 566 KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQL 622
Cdd:COG1196 723 EEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
813-1375 |
3.52e-09 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 61.57 E-value: 3.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 813 SKQLEMEKEIvSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKiqheELNNRIQTTVTELQKVKMEKEA 892
Cdd:TIGR04523 33 TEEKQLEKKL-KTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIK----DLNDKLKKNKDKINKLNSDLSK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 893 LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKhQLQVQMENTLKEQKELKKSLEKEKEASHQLK 972
Cdd:TIGR04523 108 INSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELE-KLNNKYNDLKKQKEELENELNLLEKEKLNIQ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 973 LELNSMQEQLIQAQNTL---KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKiavlQKTELENKLQQQLTQAAQEL 1049
Cdd:TIGR04523 187 KNIDKIKNKLLKLELLLsnlKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEIN----EKTTEISNTQTQLNQLKDEQ 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1050 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ------------DLKSVEEKLSLAQEDLISNRNQIGNQNK 1117
Cdd:TIGR04523 263 NKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNqkeqdwnkelksELKNQEKKLEEIQNQISQNNKIISQLNE 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1118 LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK---SHKL 1194
Cdd:TIGR04523 343 QISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKklqQEKE 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1195 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEaKLHSEIKEKEVGMKKH 1274
Cdd:TIGR04523 423 LLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLE-QKQKELKSKEKELKKL 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1275 EENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ--DERRALLERCLKGEGEIEKLQ 1352
Cdd:TIGR04523 502 NEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENleKEIDEKNKEIEELKQTQKSLK 581
|
570 580
....*....|....*....|...
gi 767975501 1353 TKVLELQRKLDNTTAAVQELGRE 1375
Cdd:TIGR04523 582 KKQEEKQELIDQKEKEKKDLIKE 604
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
938-1170 |
3.62e-09 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 60.55 E-value: 3.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 938 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 1017
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1018 EALQGELK--IAVLQKTELENKLQQQLTQAAQELAAekekisvlqnnyeKSQETFKQLQSDFYGRESELLATRQDLKSVE 1095
Cdd:COG4942 100 EAQKEELAelLRALYRLGRQPPLALLLSPEDFLDAV-------------RRLQYLKYLAPARREQAEELRADLAELAALR 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 1096 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE 1170
Cdd:COG4942 167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| FYVE_ZFY19 |
cd15749 |
FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins; ... |
1399-1448 |
4.59e-09 |
|
FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins; ZFY19, also termed mixed lineage leukemia (MLL) partner containing FYVE domain, is encoded by a novel gene, MLL partner containing FYVE domain (MPFYVE). The FYVE domain of ZFY19 resembles FYVE-related domains that are structurally similar to the canonical FYVE domains but lack the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. The biological function of ZFY19 remains unclear.
Pssm-ID: 277288 [Multi-domain] Cd Length: 51 Bit Score: 53.66 E-value: 4.59e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1399 NCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPS-SKKPVRVCDACF 1448
Cdd:cd15749 1 RCFGCAAKFSLFKKECGCKNCGRSFCKGCLTFSAVVPRkGNQKQKVCKQCH 51
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
150-507 |
6.61e-09 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 60.84 E-value: 6.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 150 ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLRE 229
Cdd:TIGR02168 678 EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELT 757
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 230 AAEQKVTRLTEELNKEATVIQdlktellqrpgiedvavlkkelvqvqtlmdnmtlERERESEKLKDECKKLQSQYASSEA 309
Cdd:TIGR02168 758 ELEAEIEELEERLEEAEEELA----------------------------------EAEAEIEELEAQIEQLKEELKALRE 803
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 310 TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLhqkdldcQ 389
Cdd:TIGR02168 804 ALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESEL-------E 876
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 390 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEkeqhglqLQSEINQLHSKLLETE 469
Cdd:TIGR02168 877 ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-------LEVRIDNLQERLSEEY 949
|
330 340 350
....*....|....*....|....*....|....*...
gi 767975501 470 RQLGEAHGRLKEQRQLSSEKLmdkEQQVADLQLKLSRL 507
Cdd:TIGR02168 950 SLTLEEAEALENKIEDDEEEA---RRRLKRLENKIKEL 984
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
970-1198 |
8.43e-09 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 59.39 E-value: 8.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 970 QLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1049
Cdd:COG4942 24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1050 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATL 1129
Cdd:COG4942 104 EELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAEL 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1130 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK 1198
Cdd:COG4942 184 EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALK 252
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
293-1170 |
9.22e-09 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 60.45 E-value: 9.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 293 LKDECKKLQSQYASSEATISQLRSELakgpQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHneesv 372
Cdd:TIGR00606 222 IRDQITSKEAQLESSREIVKSYENEL----DPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKM----- 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 373 sKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE--VETKYQHLKAEFKQLQQQREEKEQH 450
Cdd:TIGR00606 293 -EKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTEllVEQGRLQLQADRHQEHIRARDSLIQ 371
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 451 GLQLQSEINQLHSKLlETERQLGEAHgRLKEQRQLSSEKLMDkeQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQ 530
Cdd:TIGR00606 372 SLATRLELDGFERGP-FSERQIKNFH-TLVIERQEDEAKTAA--QLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKE 447
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 531 QHQEQQALQQSTTAKLREAQNDLEQVLRqigdKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE---GETAVLNQ 607
Cdd:TIGR00606 448 ILEKKQEELKFVIKELQQLEGSSDRILE----LDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADldrKLRKLDQE 523
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 608 LQEKNH--TLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH----------LRAAQDRVLSLETSVNELNSQLNES 675
Cdd:TIGR00606 524 MEQLNHhtTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYfpnkkqledwLHSKSKEINQTRDRLAKLNKELASL 603
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 676 KEKVSQLDIQIKAKTELLLSAE------AAKTAQRADLQNHLDTAQNALQDKQQeLNKITTQLDQVTAKLQDKQEHC--- 746
Cdd:TIGR00606 604 EQNKNHINNELESKEEQLSSYEdklfdvCGSQDEESDLERLKEEIEKSSKQRAM-LAGATAVYSQFITQLTDENQSCcpv 682
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 747 --------SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 818
Cdd:TIGR00606 683 cqrvfqteAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQR 762
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 819 EKEivsstrlDLQKKSEALESIKQKltkqEEEKKILKQDFeTLSQETKIQHEELNNRIQTTVTELQKVKMEKEalMTELS 898
Cdd:TIGR00606 763 LKN-------DIEEQETLLGTIMPE----EESAKVCLTDV-TIMERFQMELKDVERKIAQQAAKLQGSDLDRT--VQQVN 828
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 899 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQlQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSM 978
Cdd:TIGR00606 829 QEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSE-KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDA 907
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 979 QEQLIQAQNTLKQNEKEEQQLqgnINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1058
Cdd:TIGR00606 908 KEQDSPLETFLEKDQQEKEEL---ISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNA 984
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1059 LQNNYEKSQETFKQ-------------LQSDFYGRESELLATRQDLKSVEEklSLAQEDLISNRNQIGNQNKLIQELKTA 1125
Cdd:TIGR00606 985 QLEECEKHQEKINEdmrlmrqdidtqkIQERWLQDNLTLRKRENELKEVEE--ELKQHLKEMGQMQVLQMKQEHQKLEEN 1062
|
890 900 910 920
....*....|....*....|....*....|....*....|....*
gi 767975501 1126 KATLEQDSAKKEQQLQERCKalQDIQKEKSLKEKELVNEKSKLAE 1170
Cdd:TIGR00606 1063 IDLIKRNHVLALGRQKGYEK--EIKHFKKELREPQFRDAEEKYRE 1105
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
289-779 |
1.42e-08 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 59.65 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 289 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKssvNELTQKNQTLTeNLLKKEQDYTKLEEKHN 368
Cdd:TIGR04523 146 EIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIK---NKLLKLELLLS-NLKKKIQKNKSLESQIS 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 369 EESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIhveLSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 448
Cdd:TIGR04523 222 ELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQL---KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEIS 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 449 QHGLQLQSEIN-QLHSKLLETERQLGEAHGRLKEQRQLSSEKlmdkEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 527
Cdd:TIGR04523 299 DLNNQKEQDWNkELKSELKNQEKKLEEIQNQISQNNKIISQL----NEQISQLKKELTNSESENSEKQRELEEKQNEIEK 374
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 528 TKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 607
Cdd:TIGR04523 375 LKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEL 454
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 608 LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 687
Cdd:TIGR04523 455 IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKK 534
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 688 AKTELLLSAEAAKTAQRADLQNhlDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 767
Cdd:TIGR04523 535 EKESKISDLEDELNKDDFELKK--ENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKI 612
|
490
....*....|..
gi 767975501 768 EELEGQIKKLEA 779
Cdd:TIGR04523 613 SSLEKELEKAKK 624
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
541-780 |
2.22e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 57.85 E-value: 2.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 541 STTAKLREAQNDLEQVlrqigdkDQKIQNLEALLQKSKENISLLEKEREDLYAKIqagegetavlNQLQEKNHTLQEQVT 620
Cdd:COG4942 17 AQADAAAEAEAELEQL-------QQEIAELEKELAALKKEEKALLKQLAALERRI----------AALARRIRALEQELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 621 QLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQdrVLSLETSVNELNSQlnESKEKVSQLDIQIKAKTELLLSAEAAK 700
Cdd:COG4942 80 ALEAELAELEKEIAELRAELEAQKEELAELLRALY--RLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEEL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 701 TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 780
Cdd:COG4942 156 RADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
606-1191 |
2.37e-08 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 58.88 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 606 NQLQEKNHTLQEQVTQLTEKLKNQseshKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 685
Cdd:TIGR04523 71 NNSNNKIKILEQQIKDLNDKLKKN----KDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTE 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 686 IKAKTELLLSAEAAK---TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLqdkqehcsqleSHLKEYKEKYLS 762
Cdd:TIGR04523 147 IKKKEKELEKLNNKYndlKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLL-----------SNLKKKIQKNKS 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 763 LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 842
Cdd:TIGR04523 216 LESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKS 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 843 KLTKQEEEKK-ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE-- 919
Cdd:TIGR04523 296 EISDLNNQKEqDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEkl 375
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 920 -KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKsLEKEKEashQLKLELNSMQEQLIQAQNTLKQNEKEEQQ 998
Cdd:TIGR04523 376 kKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKK-LQQEKE---LLEKEIERLKETIIKNNSEIKDLTNQDSV 451
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 999 LQGNINELKQSSEQKKKQIEALQGELKIAvlqKTELENKLQQQLTQAAqELAAEKEKISVLQNNYEKSQETFKQLQSDFY 1078
Cdd:TIGR04523 452 KELIIKNLDNTRESLETQLKVLSRSINKI---KQNLEQKQKELKSKEK-ELKKLNEEKKELEEKVKDLTKKISSLKEKIE 527
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1079 GRESELLATRQDLKSVEEKLSLAQEDLISN--RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1156
Cdd:TIGR04523 528 KLESEKKEKESKISDLEDELNKDDFELKKEnlEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEE 607
|
570 580 590
....*....|....*....|....*....|....*
gi 767975501 1157 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS 1191
Cdd:TIGR04523 608 KEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNK 642
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1095-1389 |
2.38e-08 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 58.79 E-value: 2.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1095 EEKLSLAQEDLisNRNQIgnqnkLIQELKTAKATLEQDSAK-----------KEQQLQERCKALQDIQKEKSLKEKELVN 1163
Cdd:COG1196 178 ERKLEATEENL--ERLED-----ILGELERQLEPLERQAEKaeryrelkeelKELEAELLLLKLRELEAELEELEAELEE 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1164 EKSKLAEIEEikcrQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQvk 1243
Cdd:COG1196 251 LEAELEELEA----ELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEE-- 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1244 keeeelKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL 1323
Cdd:COG1196 325 ------LAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAEL 398
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 1324 EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNR 1389
Cdd:COG1196 399 AAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEL 464
|
|
| FYVE_RUFY3 |
cd15744 |
FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar ... |
1400-1448 |
3.28e-08 |
|
FYVE-related domain found in RUN and FYVE domain-containing protein 3 (RUFY3) and similar proteins; RUFY3, also termed Rap2-interacting protein x (RIPx or RPIPx), or single axon-regulated protein (singar), is an N-terminal RUN domain and a C-terminal FYVE domain containing protein predominantly expressed in the brain. It suppresses formation of surplus axons for neuronal polarity. Unlike other RUFY proteins, RUFY3 can associate with the GTP-bound active form of Rab5. Moreover, the FYVE domain of RUFY3 resembles the FYVE-related domain as it lacks the WxxD motif (x for any residue).
Pssm-ID: 277283 [Multi-domain] Cd Length: 52 Bit Score: 51.26 E-value: 3.28e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1400 CMACGK-GFSVTVRRHHCRQCGNIFCAECSAKNALTPSS-KKPVRVCDACF 1448
Cdd:cd15744 2 CSLCQEdFASLALPKHNCYNCGGTFCDACSSNELPLPSSiYEPARVCDVCY 52
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
307-734 |
4.18e-08 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 58.00 E-value: 4.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 307 SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQknqtltenllkkeQDYTKLEEKHNEESVSKKNIQATLHQKDL 386
Cdd:PRK11281 78 QKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETR-------------ETLSTLSLRQLESRLAQTLDQLQNAQNDL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 387 DcqQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEfkqlQQQREEKEQHGLQLQSEINQlhsKLL 466
Cdd:PRK11281 145 A--EYNSQLVSLQTQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRPS----QRVLLQAEQALLNAQNDLQR---KSL 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 467 ETERQLGEAhgrLKEQRQLSSEKLMDKEQQVADLQlklsrleEQLKEKvtnstelqhqldktkqqhqeqqalqqsttaKL 546
Cdd:PRK11281 216 EGNTQLQDL---LQKQRDYLTARIQRLEHQLQLLQ-------EAINSK------------------------------RL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 547 REAQNDLEQVLRQigDKDQKIQNLEALLQKSKENISLlekeREDLyakIQAgegeTAVLNQLQEKNhtlqeqvtqltEKL 626
Cdd:PRK11281 256 TLSEKTVQEAQSQ--DEAARIQANPLVAQELEINLQL----SQRL---LKA----TEKLNTLTQQN-----------LRV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 627 KNQSESHKQAQENLHDQV-------------QEQKAHLRAAQ------DRVLSLETSVNELNSQlnesKEKVSQLDIQIK 687
Cdd:PRK11281 312 KNWLDRLTQSERNIKEQIsvlkgslllsrilYQQQQALPSADlieglaDRIADLRLEQFEINQQ----RDALFQPDAYID 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 767975501 688 AkteLLLSAEAAKTAQ-RADLQNHLDTAQNALQDKQQELN-----KITTQLDQ 734
Cdd:PRK11281 388 K---LEAGHKSEVTDEvRDALLQLLDERRELLDQLNKQLNnqlnlAINLQLNQ 437
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
390-893 |
4.86e-08 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 57.77 E-value: 4.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 390 QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEqhglQLQSEINQLHSKLLETE 469
Cdd:PRK03918 190 NIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELE----SLEGSKRKLEEKIRELE 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 470 RQLGEAHGRLKEQRqlSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 549
Cdd:PRK03918 266 ERIEELKKEIEELE--EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEEL 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 550 QNDLEQVLRQIGDKDQKIQNLEALLQKsKENISLLEKEREDLyakiqAGEGETAVLNQLQEKNHTLQEQVTQLTEK---L 626
Cdd:PRK03918 344 KKKLKELEKRLEELEERHELYEEAKAK-KEELERLKKRLTGL-----TPEKLEKELEELEKAKEEIEEEISKITARigeL 417
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 627 KNQSESHKQAQENLHD------------QVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLL 694
Cdd:PRK03918 418 KKEIKELKKAIEELKKakgkcpvcgrelTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIK 497
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 695 SAEAAKtaQRADLQNHLDTAQ-NALQDKQQELNKITTQLDQVTAK---LQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 770
Cdd:PRK03918 498 LKELAE--QLKELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKGEiksLKKELEKLEELKKKLAELEKKLDELEEELAEL 575
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 771 EGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTK---- 846
Cdd:PRK03918 576 LKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEElekk 655
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 767975501 847 -QEEEKKILKQDFETLSQE---TKIQHEELNNRIQTTVTELQKVKMEKEAL 893
Cdd:PRK03918 656 ySEEEYEELREEYLELSRElagLRAELEELEKRREEIKKTLEKLKEELEER 706
|
|
| FYVE_WDFY1 |
cd15756 |
FYVE domain found in WD40 repeat and FYVE domain-containing protein 1 (WDFY1) and similar ... |
1390-1452 |
5.12e-08 |
|
FYVE domain found in WD40 repeat and FYVE domain-containing protein 1 (WDFY1) and similar proteins; WDFY1, also termed FYVE domain containing protein localized to endosomes-1 (FENS-1), or phosphoinositide-binding protein 1, or zinc finger FYVE domain-containing protein 17, is a novel single FYVE domain containing protein that binds phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) with high specificity over other phosphoinositides. WDFY1 to early endosomes requires an intact FYVE domain and is inhibited by wortmannin, a PI3-kinase inhibitor. In addition to FYVE domain, WDFY1 harbors multiple WD-40 repeats.
Pssm-ID: 277295 [Multi-domain] Cd Length: 76 Bit Score: 51.61 E-value: 5.12e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 1390 KWAEDNevqNCMACGKGF-----------SVTVRRHHCRQCGNIFCAECSAKNALTP--SSKKPVRVCDACFNDLQ 1452
Cdd:cd15756 2 QWLESD---SCQKCEQPFfwnikqmwdtkTLGLRQHHCRKCGQAVCGKCSSKRSSYPimGFEFQVRVCDSCFETIK 74
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
553-1327 |
5.14e-08 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 57.82 E-value: 5.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 553 LEQVLRQIGDKDQKIQNLEALLQKSKeniSLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSES 632
Cdd:pfam15921 80 LEEYSHQVKDLQRRLNESNELHEKQK---FYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 633 HKQAQENLHDQVQEQKAHLRAAqdrVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQradLQNHLD 712
Cdd:pfam15921 157 AKCLKEDMLEDSNTQIEQLRKM---MLSHEGVLQEIRSILVDFEEASGKKIYEHDSMSTMHFRSLGSAISK---ILRELD 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 713 TAQNALQDKqqeLNKITTQLDQVTAKLQDK-----QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAdslEVKAS 787
Cdd:pfam15921 231 TEISYLKGR---IFPVEDQLEALKSESQNKielllQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQS---QLEII 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 788 KEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSstrldlqkksEALESIKQKLTKQEEEKKILKQDFETLSQETKi 867
Cdd:pfam15921 305 QEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYE----------DKIEELEKQLVLANSELTEARTERDQFSQESG- 373
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 868 qheELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKgkaaILDLEKTCKELKHQLQVQM 947
Cdd:pfam15921 374 ---NLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNME----VQRLEALLKAMKSECQGQM 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 948 ENTLKEQKELKKSLEKEKEASHQL---KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG-- 1022
Cdd:pfam15921 447 ERQMAAIQGKNESLEKVSSLTAQLestKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSrv 526
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1023 ELKIAVLQKTELENKLQQQLTQAAQELA---AEKEK-ISVLQNNYEKSQETFKQlqsdfYGRESEllATRQDLKSVEEKL 1098
Cdd:pfam15921 527 DLKLQELQHLKNEGDHLRNVQTECEALKlqmAEKDKvIEILRQQIENMTQLVGQ-----HGRTAG--AMQVEKAQLEKEI 599
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1099 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEikcrq 1178
Cdd:pfam15921 600 NDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSE----- 674
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1179 EKEITKLNEELKSHKLEsikeiTNLKDAKQLLIQQKLELQGKADSLKAaveQEKRNQQILKdqVKKEEEELKKEFIEKEA 1258
Cdd:pfam15921 675 DYEVLKRNFRNKSEEME-----TTTNKLKMQLKSAQSELEQTRNTLKS---MEGSDGHAMK--VAMGMQKQITAKRGQID 744
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1259 KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATV 1327
Cdd:pfam15921 745 ALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANMEVAL 813
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
985-1191 |
6.09e-08 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 56.70 E-value: 6.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 985 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK---IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1061
Cdd:COG4942 18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAaleRRIAALARRIRALEQELAALEAELAELEKEIAELRA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1062 NYEKSQETFKQLQSDFY--GRES--ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1137
Cdd:COG4942 98 ELEAQKEELAELLRALYrlGRQPplALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELE 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 767975501 1138 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS 1191
Cdd:COG4942 178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
119-986 |
6.16e-08 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 57.67 E-value: 6.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 119 NLALKRDDVTLLRQEVQDLQASLKEEKWYSeelKKELEKYQGLQQQEAKPDGLVTDSsaELQSLEQQLEEAQTENFNIKQ 198
Cdd:pfam02463 177 KLIEETENLAELIIDLEELKLQELKLKEQA---KKALEYYQLKEKLELEEEYLLYLD--YLKLNEERIDLLQELLRDEQE 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 199 MKDLFEQKAAQLATEIADIKSKYDEErsLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL 278
Cdd:pfam02463 252 EIESSKQEIEKEEEKLAQVLKENKEE--EKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKE 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 279 MDNMTLERErESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 358
Cdd:pfam02463 330 LKKEKEEIE-ELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQ 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 359 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSasetslhrihvelsekgeatQKLKEELSEVETKYQHLKAEFK 438
Cdd:pfam02463 409 LLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKL--------------------TEEKEELEKQELKLLKDELELK 468
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 439 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEqlKEKVTNS 518
Cdd:pfam02463 469 KSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVE--NYKVAIS 546
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 519 TELQHQLDKTKQQHQEQQALQQSTTAKLREAqndleQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG 598
Cdd:pfam02463 547 TAVIVEVSATADEVEERQKLVRALTELPLGA-----RKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKR 621
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 599 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 678
Cdd:pfam02463 622 AKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEI 701
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 679 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 758
Cdd:pfam02463 702 KKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEERE 781
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 759 KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALE 838
Cdd:pfam02463 782 KTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEE 861
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 839 SIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLkNSKSEF 918
Cdd:pfam02463 862 EITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYE-EEPEEL 940
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 919 EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQ 986
Cdd:pfam02463 941 LLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLI 1008
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
177-785 |
7.63e-08 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 57.23 E-value: 7.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 177 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQlaTEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 256
Cdd:COG4913 255 EPIRELAERYAAARERLAELEYLRAALRLWFAQ--RRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQI 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 257 LQRPGiEDVAVLKKELVQVQTLMDnmtlERERESEKLKDECKKLQSQYASSEATISQLRSELAkgpqevavyvQELQKLK 336
Cdd:COG4913 333 RGNGG-DRLEQLEREIERLERELE----ERERRRARLEALLAALGLPLPASAEEFAALRAEAA----------ALLEALE 397
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 337 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQ-KDldcqQLQSRLSASETSLHRI--HVELSEKG 413
Cdd:COG4913 398 EELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLAlRD----ALAEALGLDEAELPFVgeLIEVRPEE 473
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 414 EA----------TQKL-----KEELSEVETKYQHLKAEfKQLQQQREEKEQHGLQLQS-EINQLHSKLL----------- 466
Cdd:COG4913 474 ERwrgaiervlgGFALtllvpPEHYAAALRWVNRLHLR-GRLVYERVRTGLPDPERPRlDPDSLAGKLDfkphpfrawle 552
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 467 ------------ETERQL---------------GEAHGRLKEQRQLSS---------EKLMDKEQQVADLQLKLSRLEEQ 510
Cdd:COG4913 553 aelgrrfdyvcvDSPEELrrhpraitragqvkgNGTRHEKDDRRRIRSryvlgfdnrAKLAALEAELAELEEELAEAEER 632
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 511 LKEkvtnSTELQHQLDKtkqqhqeqQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAllqkSKENISLLEKERED 590
Cdd:COG4913 633 LEA----LEAELDALQE--------RREALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEE 696
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 591 LYAKIQAGEGEtavLNQLQEKNHTLQEQVTQLTEKLknqseshKQAQENLHDQVQEQKAHLRAAQDRVLSLEtsvnelns 670
Cdd:COG4913 697 LEAELEELEEE---LDELKGEIGRLEKELEQAEEEL-------DELQDRLEAAEDLARLELRALLEERFAAA-------- 758
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 671 qlneskekvsqldiqikAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNK----ITTQLDQVTAKLQDKQEHC 746
Cdd:COG4913 759 -----------------LGDAVERELRENLEERIDALRARLNRAEEELERAMRAFNRewpaETADLDADLESLPEYLALL 821
|
650 660 670 680
....*....|....*....|....*....|....*....|..
gi 767975501 747 SQLE-SHLKEYKEKYLSL--EQKTEELEGQIKKLEADSLEVK 785
Cdd:COG4913 822 DRLEeDGLPEYEERFKELlnENSIEFVADLLSKLRRAIREIK 863
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
520-744 |
1.06e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 55.93 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 520 ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 599
Cdd:COG4942 24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 600 GETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRvlsletsVNELNSQLNESKEKV 679
Cdd:COG4942 104 EELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAE-------LAALRAELEAERAEL 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 680 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 744
Cdd:COG4942 177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
692-928 |
1.45e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 55.54 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 692 LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELE 771
Cdd:COG4942 10 LLALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 772 GQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 851
Cdd:COG4942 90 KEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 852 KILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAA 928
Cdd:COG4942 170 EAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
642-1191 |
1.52e-07 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 56.34 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 642 DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEaaktAQRADLQNHLDTAQNALQDK 721
Cdd:pfam01576 5 EEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAE----EMRARLAARKQELEEILHEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 722 QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQqrql 801
Cdd:pfam01576 81 ESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 802 ntdLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE---EEKKILKQDFETLSQETKIQHEELNNRIQT 878
Cdd:pfam01576 157 ---LEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEkgrQELEKAKRKLEGESTDLQEQIAELQAQIAE 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 879 TVTELQKVKMEKEALMTEL---STVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV---QMENTL- 951
Cdd:pfam01576 234 LRAQLAKKEEELQAALARLeeeTAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEAlktELEDTLd 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 952 -------------KEQKELKKSLEKEKEASHQLKLE--------LNSMQEQLIQAQNTLKQNEKEEQQLQGNINEL---- 1006
Cdd:pfam01576 314 ttaaqqelrskreQEVTELKKALEEETRSHEAQLQEmrqkhtqaLEELTEQLEQAKRNKANLEKAKQALESENAELqael 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1007 ------KQSSEQKKKQIEA----LQGELKIAVLQKTELEnklqqqltqaaqelaaekEKISVLQNNYEKSQETFKQLqsd 1076
Cdd:pfam01576 394 rtlqqaKQDSEHKRKKLEGqlqeLQARLSESERQRAELA------------------EKLSKLQSELESVSSLLNEA--- 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1077 fygrESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1156
Cdd:pfam01576 453 ----EGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSD 528
|
570 580 590
....*....|....*....|....*....|....*
gi 767975501 1157 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS 1191
Cdd:pfam01576 529 MKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEE 563
|
|
| FYVE_CARP |
cd15750 |
FYVE-like domain found in caspase-associated ring proteins, CARP1 and CARP2; CARP1 and CARP2 ... |
1399-1447 |
1.72e-07 |
|
FYVE-like domain found in caspase-associated ring proteins, CARP1 and CARP2; CARP1 and CARP2 are a novel group of caspase regulators by the presence of a FYVE-type zinc finger domain. They do not localize to membranes in the cell and are involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8 and caspase 10, which are distinguished from other FYVE-type proteins. Moreover, these proteins have an altered sequence in the basic ligand binding patch and lack the WxxD (x for any residue) motif that is conserved only in phosphoinositide binding FYVE domains. Thus they constitute a family of unique FYVE-type domains called FYVE-like domains.
Pssm-ID: 277289 [Multi-domain] Cd Length: 47 Bit Score: 48.90 E-value: 1.72e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767975501 1399 NCMACGKGFSVTVRRHHCRQCGNIFCAECSAKnaltpsSKKPVRVCDAC 1447
Cdd:cd15750 2 PCESCGAKFSVFKRKRTCADCKRYFCSNCLSK------EERGRRRCRRC 44
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
123-667 |
1.94e-07 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 55.82 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 123 KRDDVTLLRQEVQDLQASLKEEKWYSEELKKEL-EKYQGLQQQEAKPDGLVTDS---SAELQSLEQQLEEAQTENfnikq 198
Cdd:PRK02224 249 RREELETLEAEIEDLRETIAETEREREELAEEVrDLRERLEELEEERDDLLAEAgldDADAEAVEARREELEDRD----- 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 199 mkdlfEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL-KTELLQRPGIEDVAVLKKELVQVQT 277
Cdd:PRK02224 324 -----EELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELeEAREAVEDRREEIEELEEEIEELRE 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 278 LMDNMTLERER---ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQ--EVAVYVQELQKLKSS-----VNELTQKNQ 347
Cdd:PRK02224 399 RFGDAPVDLGNaedFLEELREERDELREREAELEATLRTARERVEEAEAllEAGKCPECGQPVEGSphvetIEEDRERVE 478
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 348 TLTENLLKKEQDYTKLEEKHNE-ESVSKKNIQAtlhqkdldcQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEV 426
Cdd:PRK02224 479 ELEAELEDLEEEVEEVEERLERaEDLVEAEDRI---------ERLEERREDLEELIAERRETIEEKRERAEELRERAAEL 549
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 427 ETKyqhlkaefkqlqqqREEKEQHGLQLQSEINQLHSKLLETERQLGEahgrLKEQRQlSSEKLMDKEQQVADLQLKLSR 506
Cdd:PRK02224 550 EAE--------------AEEKREAAAEAEEEAEEAREEVAELNSKLAE----LKERIE-SLERIRTLLAAIADAEDEIER 610
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 507 LEEQLKEKVTNSTELQHQLdktkqqhqeqqalqqsttAKLREAQNDLEQVL--RQIGDKDQKIQNLEALLQKSKENISLL 584
Cdd:PRK02224 611 LREKREALAELNDERRERL------------------AEKRERKRELEAEFdeARIEEAREDKERAEEYLEQVEEKLDEL 672
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 585 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLteklknqseshkqaqENLHDQV---QEQKAHLRAA--QDRVL 659
Cdd:PRK02224 673 REERDDLQAEIGAVENELEELEELRERREALENRVEAL---------------EALYDEAeelESMYGDLRAElrQRNVE 737
|
....*...
gi 767975501 660 SLETSVNE 667
Cdd:PRK02224 738 TLERMLNE 745
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
672-1199 |
2.56e-07 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 55.43 E-value: 2.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 672 LNESKEKVSQLDIQIKAKTElllsaeaaktaqrADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQD---------- 741
Cdd:PRK02224 182 LSDQRGSLDQLKAQIEEKEE-------------KDLHERLNGLESELAELDEEIERYEEQREQARETRDEadevleehee 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 742 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 821
Cdd:PRK02224 249 RREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRD 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 822 IVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETL------------SQETKI-----QHEELNNRIQTTVTELQ 884
Cdd:PRK02224 329 RLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELeseleeareaveDRREEIeeleeEIEELRERFGDAPVDLG 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 885 KVKMEKEALMTELSTVKDKLSKVSDSLKNSksefekENQKGKAAILDLEKTCKELKHQLQ-VQMENTLKEQKELKKSLEK 963
Cdd:PRK02224 409 NAEDFLEELREERDELREREAELEATLRTA------RERVEEAEALLEAGKCPECGQPVEgSPHVETIEEDRERVEELEA 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 964 EKEashQLKLELNSMQEQLIQAQnTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEnklqqqlt 1043
Cdd:PRK02224 483 ELE---DLEEEVEEVEERLERAE-DLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELE-------- 550
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1044 qaaQELAAEKEKISVLQNNYEKSQETFKQLQSdfygRESELLATRQDLKSVEEKLSLAQEdlisNRNQIGNQNkliqELK 1123
Cdd:PRK02224 551 ---AEAEEKREAAAEAEEEAEEAREEVAELNS----KLAELKERIESLERIRTLLAAIAD----AEDEIERLR----EKR 615
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1124 TAKATLEQDSAKKEQQLQERCKAL---------QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKShkL 1194
Cdd:PRK02224 616 EALAELNDERRERLAEKRERKRELeaefdeariEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEE--L 693
|
....*
gi 767975501 1195 ESIKE 1199
Cdd:PRK02224 694 EELRE 698
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
423-1020 |
2.64e-07 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 55.29 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 423 LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKlmdkeqqvadlql 502
Cdd:PRK01156 185 IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMK------------- 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 503 klSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI- 581
Cdd:PRK01156 252 --NRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIk 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 582 --SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLtEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVL 659
Cdd:PRK01156 330 klSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSI-ESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIK 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 660 SLetsVNELNSQLNESKEKVSQLDIQIKAKTELLLsaEAAKTAQRADLQN-------HL--DTAQNALQDKQQELNKITT 730
Cdd:PRK01156 409 KE---LNEINVKLQDISSKVSSLNQRIRALRENLD--ELSRNMEMLNGQSvcpvcgtTLgeEKSNHIINHYNEKKSRLEE 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 731 QLDQV---TAKLQDKQEHCSQLESHL-KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKaskeqalqdlqqqrqlntDLE 806
Cdd:PRK01156 484 KIREIeieVKDIDEKIVDLKKRKEYLeSEEINKSINEYNKIESARADLEDIKIKINELK------------------DKH 545
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 807 LRATELSKQLE-MEKEIVSSTRLDLQKKSEALESIK-QKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTelq 884
Cdd:PRK01156 546 DKYEEIKNRYKsLKLEDLDSKRTSWLNALAVISLIDiETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIR--- 622
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 885 kvKMEKEAlmtelstvkdklskvsDSLKNSKsefeKENQKGKAAILDLEKTCKELKHQLQvQMENTLKEQKELKKSLEKE 964
Cdd:PRK01156 623 --EIENEA----------------NNLNNKY----NEIQENKILIEKLRGKIDNYKKQIA-EIDSIIPDLKEITSRINDI 679
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 965 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 1020
Cdd:PRK01156 680 EDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKIKKAI 735
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
545-1282 |
2.87e-07 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 55.11 E-value: 2.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 545 KLREAQNDLEQVLRQigdKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL----NQLQEKNHTLQEQVT 620
Cdd:pfam05483 89 KIKKWKVSIEAELKQ---KENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLikenNATRHLCNLLKETCA 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 621 QLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTElllsaeaak 700
Cdd:pfam05483 166 RSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEIN--------- 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 701 taqraDLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLeqkTEELEGQIKKLEAD 780
Cdd:pfam05483 237 -----DKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHL---TKELEDIKMSLQRS 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 781 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFET 860
Cdd:pfam05483 309 MSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQK 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 861 LSQETKiQHEELNNRIQTTVTELQKVKMEKEALMTElstvKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 940
Cdd:pfam05483 389 KSSELE-EMTKFKNNKEVELEELKKILAEDEKLLDE----KKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIK 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 941 hqlqVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 1020
Cdd:pfam05483 464 ----TSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENL 539
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1021 QGelkiavlQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSL 1100
Cdd:pfam05483 540 EE-------KEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEE 612
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1101 AQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEikcrqek 1180
Cdd:pfam05483 613 LHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIAD------- 685
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1181 EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEkrnQQILKDQVKKEEEELKKEFIEKEAKL 1260
Cdd:pfam05483 686 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQE---QSSAKAALEIELSNIKAELLSLKKQL 762
|
730 740
....*....|....*....|..
gi 767975501 1261 HSEIKEKEVGMKKHEENEAKLT 1282
Cdd:pfam05483 763 EIEKEEKEKLKMEAKENTAILK 784
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1117-1387 |
4.03e-07 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 54.94 E-value: 4.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1117 KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEikcrqekEITKLNEELkshkLES 1196
Cdd:COG1196 225 LEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELEL-------ELEEAQAEE----YEL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1197 IKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQvkkeEEELKKEFIEKEAKLHS---EIKEKEVGMKK 1273
Cdd:COG1196 294 LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEE----LEELEEELEEAEEELEEaeaELAEAEEALLE 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1274 HEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQT 1353
Cdd:COG1196 370 AEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449
|
250 260 270
....*....|....*....|....*....|....
gi 767975501 1354 KVLELQRKLDNTTAAVQELGRENQSLQIKHTQAL 1387
Cdd:COG1196 450 EEAELEEEEEALLELLAELLEEAALLEAALAELL 483
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
198-728 |
4.52e-07 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 54.68 E-value: 4.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 198 QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEqKVTRLTEELNKEATVIQDLKTELLQRPGieDVAVLKKELVQVQT 277
Cdd:PRK03918 190 NIEELIKEKEKELEEVLREINEISSELPELREELE-KLEKEVKELEELKEEIEELEKELESLEG--SKRKLEEKIRELEE 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 278 LMDNMTLERERESEKLKD--ECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK 355
Cdd:PRK03918 267 RIEELKKEIEELEEKVKElkELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKK 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 356 KEQ---DYTKLEEKHneesvskkniqatlhqkdldcqQLQSRLSASETSLHRIHVELseKGEATQKLKEELSEVETKYQH 432
Cdd:PRK03918 347 LKElekRLEELEERH----------------------ELYEEAKAKKEELERLKKRL--TGLTPEKLEKELEELEKAKEE 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 433 LKAEFKQLQQQREEKEQHGLQLQSEINQLHS---KLLETERQLGEAH-GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 508
Cdd:PRK03918 403 IEEEISKITARIGELKKEIKELKKAIEELKKakgKCPVCGRELTEEHrKELLEEYTAELKRIEKELKEIEEKERKLRKEL 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 509 EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEnislLEKER 588
Cdd:PRK03918 483 RELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEE----LKKKL 558
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 589 EDLYAKIQAGEGETA-VLNQLQEKNHTLQEQVTQLTEKLK------NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 661
Cdd:PRK03918 559 AELEKKLDELEEELAeLLKELEELGFESVEELEERLKELEpfyneyLELKDAEKELEREEKELKKLEEELDKAFEELAET 638
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 662 ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE-AAKTAQRADLQNHLDTAQNALQDKQQELNKI 728
Cdd:PRK03918 639 EKRLEELRKELEELEKKYSEEEYEELREEYLELSRElAGLRAELEELEKRREEIKKTLEKLKEELEER 706
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
179-576 |
5.12e-07 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 54.13 E-value: 5.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 179 LQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIK---SKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTE 255
Cdd:pfam07888 47 LQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKeelRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 256 LLQRpgiedvavlKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKL 335
Cdd:pfam07888 127 HEAR---------IRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQEL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 336 KSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAtlhqkdldcqqLQSRLSASEtslhrihvelsekgEA 415
Cdd:pfam07888 198 RNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRS-----------LQERLNASE--------------RK 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 416 TQKLKEELSEVETkyqhlkaefkqlQQQREEKEQHGLQLQSEinQLHSKLLETERQLGEAHGRLKEQR---QLSSEKLMD 492
Cdd:pfam07888 253 VEGLGEELSSMAA------------QRDRTQAELHQARLQAA--QLTLQLADASLALREGRARWAQERetlQQSAEADKD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 493 K-EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 571
Cdd:pfam07888 319 RiEKLSAELQRLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLE 398
|
....*
gi 767975501 572 ALLQK 576
Cdd:pfam07888 399 QRLET 403
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
171-1024 |
6.51e-07 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 54.28 E-value: 6.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 171 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREaAEQKVTRLTEELNKEATVIQ 250
Cdd:TIGR00606 194 VRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKN-RLKEIEHNLSKIMKLDNEIK 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 251 DLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERE-----RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEV 325
Cdd:TIGR00606 273 ALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNhqrtvREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRL 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 326 AVYVQELQKLKSSVNELTQKNQTLTEnLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 405
Cdd:TIGR00606 353 QLQADRHQEHIRARDSLIQSLATRLE-LDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEI 431
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 406 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREekeqhglqlqsEINQLHSKLLETERQLGEAHGRLKEQRQL 485
Cdd:TIGR00606 432 RDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSD-----------RILELDQELRKAERELSKAEKNSLTETLK 500
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 486 SSEKLMDKEQqvADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREaqndleqVLRQIGDKDQ 565
Cdd:TIGR00606 501 KEVKSLQNEK--ADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDE-------LTSLLGYFPN 571
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 566 KIQnLEALLQKSKENISLLEKEREDLYAKIQAGEGETavlNQLQEKNHTLQEQVTQLTEKLKN--QSESHKQAQENLHDQ 643
Cdd:TIGR00606 572 KKQ-LEDWLHSKSKEINQTRDRLAKLNKELASLEQNK---NHINNELESKEEQLSSYEDKLFDvcGSQDEESDLERLKEE 647
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 644 VQEQKAHLRAAQDRVLSLETSVNELNSQlNESKEKVSQLDIQIKAKTELLLSaeaaktaqraDLQNHLDTAQNALQDKQQ 723
Cdd:TIGR00606 648 IEKSSKQRAMLAGATAVYSQFITQLTDE-NQSCCPVCQRVFQTEAELQEFIS----------DLQSKLRLAPDKLKSTES 716
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 724 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAdSLEVKASKEQALQDLQQQRQLNT 803
Cdd:TIGR00606 717 ELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQET-LLGTIMPEEESAKVCLTDVTIME 795
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 804 DLELRATELSKQLEMEKEIVSSTRLD-----LQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQT 878
Cdd:TIGR00606 796 RFQMELKDVERKIAQQAAKLQGSDLDrtvqqVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQ 875
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 879 TVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK--SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 956
Cdd:TIGR00606 876 IGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSplETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHG 955
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 957 LKKSLEKEKEASHQLKLELNSMQEQLIQAQntLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 1024
Cdd:TIGR00606 956 YMKDIENKIQDGKDDYLKQKETELNTVNAQ--LEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNL 1021
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1095-1380 |
7.64e-07 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 53.92 E-value: 7.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1095 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE--QQLQERCK--ALQDIQKEKSLKEKELVNEKSKLAE 1170
Cdd:TIGR02169 169 DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAEryQALLKEKReyEGYELLKEKEALERQKEAIERQLAS 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1171 IEEIKCRQEKEITKLNEELKS--HKLESI-KEITNLKDAKQLLIQQKL-ELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1246
Cdd:TIGR02169 249 LEEELEKLTEEISELEKRLEEieQLLEELnKKIKDLGEEEQLRVKEKIgELEAEIASLERSIAEKERELEDAEERLAKLE 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1247 EELKKEFIEKeAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEAT 1326
Cdd:TIGR02169 329 AEIDKLLAEI-EELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRE 407
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 767975501 1327 VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1380
Cdd:TIGR02169 408 LDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLA 461
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
389-603 |
7.72e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 53.23 E-value: 7.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 389 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET 468
Cdd:COG4942 23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 469 ERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 548
Cdd:COG4942 103 KEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAE 182
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 549 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETA 603
Cdd:COG4942 183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1096-1312 |
7.72e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 53.23 E-value: 7.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1096 EKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIK 1175
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1176 CRQEKEITKLNEEL-KSHKLESIKEITNLKDAKQLLIQQKLeLQGKADSLKAAVEQEKRNQQILKdQVKKEEEELKKEFI 1254
Cdd:COG4942 100 EAQKEELAELLRALyRLGRQPPLALLLSPEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELA-ALRAELEAERAELE 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 1255 EKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQ 1312
Cdd:COG4942 178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
827-1136 |
8.29e-07 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 53.75 E-value: 8.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 827 RLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQetKIQHEE-----LNNRIQTTVTELQKVKMEKEALMTELSTVK 901
Cdd:PLN02939 99 RASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLEDLVG--MIQNAEknillLNQARLQALEDLEKILTEKEALQGKINILE 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 902 DKLSKVSDSLKNSksefekenQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 981
Cdd:PLN02939 177 MRLSETDARIKLA--------AQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAE 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 982 LIQAQNT---LKQNEKEEQQLQGNINELKQsseqkkKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV 1058
Cdd:PLN02939 249 LIEVAETeerVFKLEKERSLLDASLRELES------KFIVAQEDVSKLSPLQYDCWWEKVENLQDLLDRATNQVEKAALV 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1059 LQNNY------EKSQETFKQLQ-SDFYGRESELLatRQDLKSVEEKLSLAQEDLISnrnQIGNQNKLIQELKTAKATLEQ 1131
Cdd:PLN02939 323 LDQNQdlrdkvDKLEASLKEANvSKFSSYKVELL--QQKLKLLEERLQASDHEIHS---YIQLYQESIKEFQDTLSKLKE 397
|
....*
gi 767975501 1132 DSAKK 1136
Cdd:PLN02939 398 ESKKR 402
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
821-1027 |
1.18e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 52.46 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 821 EIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQ---ETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 897
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERriaALARRIRALEQELAALEAELAELEKEIAELRAEL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 898 STVKDKLSKVSDSL-KNSKSEFEK-----ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 971
Cdd:COG4942 100 EAQKEELAELLRALyRLGRQPPLAlllspEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 972 KLELNSMQEQLIQAQN----TLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 1027
Cdd:COG4942 180 LAELEEERAALEALKAerqkLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
284-760 |
1.90e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 52.61 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 284 LERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP-----QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQ 358
Cdd:COG4913 244 LEDAREQIELLEPIRELAERYAAARERLAELEYLRAALRlwfaqRRLELLEAELEELRAELARLEAELERLEARLDALRE 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 359 DYTKLEEKHNEESVSKKN-IQATLHQKDLDCQQLQSRLSASETSLHRIHVEL--SEKG---------EATQKLKEELSEV 426
Cdd:COG4913 324 ELDELEAQIRGNGGDRLEqLEREIERLERELEERERRRARLEALLAALGLPLpaSAEEfaalraeaaALLEALEEELEAL 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 427 ETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEkLMDKEQQVADLQ----- 501
Cdd:COG4913 404 EEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAELPFVGE-LIEVRPEEERWRgaier 482
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 502 ----LKLSRL--EEQLKE--KVTNSTELQHQLD-----KTKQQHQEQQALQQSTTAKLR----EAQNDLEQVLRQIGD-- 562
Cdd:COG4913 483 vlggFALTLLvpPEHYAAalRWVNRLHLRGRLVyervrTGLPDPERPRLDPDSLAGKLDfkphPFRAWLEAELGRRFDyv 562
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 563 -----------------------------KDQKIQNLEALL--QKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK 611
Cdd:COG4913 563 cvdspeelrrhpraitragqvkgngtrheKDDRRRIRSRYVlgFDNRAKLAALEAELAELEEELAEAEERLEALEAELDA 642
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 612 NHTLQEQVTQLTEKLKNQSEsHKQAQENLhDQVQEQKAHLRAAQDRVLSLE-------TSVNELNSQLNESKEKVSQLDI 684
Cdd:COG4913 643 LQERREALQRLAEYSWDEID-VASAEREI-AELEAELERLDASSDDLAALEeqleeleAELEELEEELDELKGEIGRLEK 720
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 685 QIKAKTELLLSAEA--------AKTAQRADLQNHLdtAQNALQDKQQEL-NKITTQLDQVTAKLQDKQEhcsQLESHLKE 755
Cdd:COG4913 721 ELEQAEEELDELQDrleaaedlARLELRALLEERF--AAALGDAVERELrENLEERIDALRARLNRAEE---ELERAMRA 795
|
....*
gi 767975501 756 YKEKY 760
Cdd:COG4913 796 FNREW 800
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
347-1382 |
2.39e-06 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 52.48 E-value: 2.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 347 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDC---QQLQSRLSASETSLHRIHVELSEKGEATQKLKEEL 423
Cdd:pfam01576 15 QKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCaeaEEMRARLAARKQELEEILHELESRLEEEEERSQQL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 424 SEVETKYQhlkAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ---LGEAHGRLKEQRQLSSEKLMDKEQQVADL 500
Cdd:pfam01576 95 QNEKKKMQ---QHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDillLEDQNSKLSKERKLLEERISEFTSNLAEE 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 501 QLKLSRLEEQLKEKVTNSTELQHQL---DKTKQQHQEQQALQQSTTAKLREA----QNDLEQVLRQIGDKDQKIQNLEAL 573
Cdd:pfam01576 172 EEKAKSLSKLKNKHEAMISDLEERLkkeEKGRQELEKAKRKLEGESTDLQEQiaelQAQIAELRAQLAKKEEELQAALAR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 574 LQKSKENISLLEKEREDLYAKI----QAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 649
Cdd:pfam01576 252 LEEETAQKNNALKKIRELEAQIselqEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRSKREQEVTE 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 650 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKIT 729
Cdd:pfam01576 332 LKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLE 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 730 TQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL--EADSLEVKASKEQALQDLQQQRQLNTDLEL 807
Cdd:pfam01576 412 GQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLskDVSSLESQLQDTQELLQEETRQKLNLSTRL 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 808 RATE-----LSKQLEMEKEI-------VSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQ------ETKIQH 869
Cdd:pfam01576 492 RQLEdernsLQEQLEEEEEAkrnverqLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQqleekaAAYDKL 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 870 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQvqmen 949
Cdd:pfam01576 572 EKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKETRALSLARALE----- 646
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 950 tlkEQKELKKSLEKekeASHQLKLELnsmqEQLIQAQNTLKQNEKEeqqLQGNINELKQSSEQKKKQIEALQGELKIAVL 1029
Cdd:pfam01576 647 ---EALEAKEELER---TNKQLRAEM----EDLVSSKDDVGKNVHE---LERSKRALEQQVEEMKTQLEELEDELQATED 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1030 QKTELENKLQQQLTQAAQELAAEKEKisvlqnNYEKSQETFKQLQSDFYGRESElLATRQDLKSVEEKLSLAQEDLISNR 1109
Cdd:pfam01576 714 AKLRLEVNMQALKAQFERDLQARDEQ------GEEKRRQLVKQVRELEAELEDE-RKQRAQAVAAKKKLELDLKELEAQI 786
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1110 NQIG-NQNKLIQELKTAKATLEQDSAKKEQQLQERCKAL-QDIQKEKSLK--EKELVNEKSKLAEIEEIKCRQEKEITKL 1185
Cdd:pfam01576 787 DAANkGREEAVKQLKKLQAQMKDLQRELEEARASRDEILaQSKESEKKLKnlEAELLQLQEDLAASERARRQAQQERDEL 866
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1186 NEELKSHKLesikeitnlkdAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKK-----------EFI 1254
Cdd:pfam01576 867 ADEIASGAS-----------GKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQlttelaaerstSQK 935
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1255 EKEAKLHSEIKEKEVGMK----------KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK-------QTDDLR 1317
Cdd:pfam01576 936 SESARQQLERQNKELKAKlqemegtvksKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKklkevllQVEDER 1015
|
1050 1060 1070 1080 1090 1100
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 1318 GEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIK 1382
Cdd:pfam01576 1016 RHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
546-751 |
2.45e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 52.22 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 546 LREAQNDLEQVLRQIgDKDQKIQNLEALLQKSKENISLLEKEREdlYAKIQAGEGETAVLNQLQEKnhtLQEQVTQLTEK 625
Cdd:COG4913 237 LERAHEALEDAREQI-ELLEPIRELAERYAAARERLAELEYLRA--ALRLWFAQRRLELLEAELEE---LRAELARLEAE 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 626 LKNQSESHKQAQENLhDQVQEQkaHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 705
Cdd:COG4913 311 LERLEARLDALREEL-DELEAQ--IRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRA 387
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 767975501 706 DLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 751
Cdd:COG4913 388 EAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLER 433
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
464-1312 |
2.90e-06 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 52.36 E-value: 2.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 464 KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDktkqqhqeqqalqqstt 543
Cdd:TIGR00606 186 KALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELD----------------- 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 544 aKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQagegetavlNQLQEKNHTLQEQVTQLT 623
Cdd:TIGR00606 249 -PLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTD---------EQLNDLYHNHQRTVREKE 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 624 EKL--------KNQSESHKQAQENLHDQVQEQKAHLRA----AQDRVLSLETSVNELNSQLnESKEKVSQLDIQIKAKTE 691
Cdd:TIGR00606 319 RELvdcqreleKLNKERRLLNQEKTELLVEQGRLQLQAdrhqEHIRARDSLIQSLATRLEL-DGFERGPFSERQIKNFHT 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 692 LLLSAEA--AKTAQR--ADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYK---EKYLSLE 764
Cdd:TIGR00606 398 LVIERQEdeAKTAAQlcADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEgssDRILELD 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 765 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELraTELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 844
Cdd:TIGR00606 478 QELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKL--DQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIK 555
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 845 TKQEEE----------KKILKQDFETLSQETKIQHEEL---NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS- 910
Cdd:TIGR00606 556 SRHSDEltsllgyfpnKKQLEDWLHSKSKEINQTRDRLaklNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSq 635
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 911 -----LKNSKSEFEKENQK-----GKAAILD----------------------LEKTCKELKHQLQVQMENTLKEQKELK 958
Cdd:TIGR00606 636 deesdLERLKEEIEKSSKQramlaGATAVYSqfitqltdenqsccpvcqrvfqTEAELQEFISDLQSKLRLAPDKLKSTE 715
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 959 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL 1038
Cdd:TIGR00606 716 SELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIME 795
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1039 QQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKL 1118
Cdd:TIGR00606 796 RFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQ 875
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1119 IQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKS----LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1194
Cdd:TIGR00606 876 IGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSpletFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHG 955
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1195 ESIKEITNLKDAKQ-LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF----IEKEAKLHSEIKEKEV 1269
Cdd:TIGR00606 956 YMKDIENKIQDGKDdYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERwlqdNLTLRKRENELKEVEE 1035
|
890 900 910 920
....*....|....*....|....*....|....*....|....*...
gi 767975501 1270 GMKKH--EENEAKLTMQITA---LNENLGTVKKEWQSSQRRVSELEKQ 1312
Cdd:TIGR00606 1036 ELKQHlkEMGQMQVLQMKQEhqkLEENIDLIKRNHVLALGRQKGYEKE 1083
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
494-742 |
3.23e-06 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 51.94 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 494 EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD--KTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLE 571
Cdd:COG3206 167 ELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQLAEARAELAEAEARLAALR 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 572 ALLQKSKENISLLekeredlyakiqageGETAVLNQLQEKnhtLQEQVTQLTEKLKNQSESHKQAQEnLHDQVQEQKAHL 651
Cdd:COG3206 247 AQLGSGPDALPEL---------------LQSPVIQQLRAQ---LAELEAELAELSARYTPNHPDVIA-LRAQIAALRAQL 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 652 RAAQDRVL-SLETSVNELNSQLNESKEKVSQLDIQIKAktelllsaEAAKTAQRADLQNHLDTAQ---NALQDKQQELnK 727
Cdd:COG3206 308 QQEAQRILaSLEAELEALQAREASLQAQLAQLEARLAE--------LPELEAELRRLEREVEVARelyESLLQRLEEA-R 378
|
250
....*....|....*
gi 767975501 728 ITTQLDQVTAKLQDK 742
Cdd:COG3206 379 LAEALTVGNVRVIDP 393
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
541-771 |
3.40e-06 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 51.56 E-value: 3.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 541 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ--KSKENISLLEKEREDLYAKIQAGEGEtavLNQLQEKNHTLQEQ 618
Cdd:COG3206 165 NLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQ---LAEARAELAEAEAR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 619 VTQLTEKLKNQSESHKQAQENlhDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLsaea 698
Cdd:COG3206 242 LAALRAQLGSGPDALPELLQS--PVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQRIL---- 315
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 699 aktaqrADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEhcsqLESHLKEYKEKYLSLEQKTEELE 771
Cdd:COG3206 316 ------ASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRR----LEREVEVARELYESLLQRLEEAR 378
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
489-705 |
4.19e-06 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 50.98 E-value: 4.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 489 KLMDKEQQVADLQLKLSRLEEQLKEkvtnsteLQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ 568
Cdd:COG3883 17 QIQAKQKELSELQAELEAAQAELDA-------LQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 569 NLEALLQKSKENISLLE-----KEREDLYAKIQAgegetavLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ 643
Cdd:COG3883 90 ERARALYRSGGSVSYLDvllgsESFSDFLDRLSA-------LSKIADADADLLEELKADKAELEAKKAELEAKLAELEAL 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975501 644 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRA 705
Cdd:COG3883 163 KAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAA 224
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
408-687 |
4.85e-06 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 51.45 E-value: 4.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 408 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQlgeAHGRLkEQRQLSS 487
Cdd:PRK11281 53 LLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRE---TLSTL-SLRQLES 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 488 eKLMDKEQQVADLQLKLSRLEEQL-----------KEKVTNSTELQhQLDKTKQQHQEQQALQQSTTAKLREAqndlEQV 556
Cdd:PRK11281 129 -RLAQTLDQLQNAQNDLAEYNSQLvslqtqperaqAALYANSQRLQ-QIRNLLKGGKVGGKALRPSQRVLLQA----EQA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 557 LRqigdkDQKIQNLEALLQKSKENISLLEKEREDLYAKIQagegetavlnQLQEKNHTLQEQVTQlteklKNQSESHKQA 636
Cdd:PRK11281 203 LL-----NAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQ----------RLEHQLQLLQEAINS-----KRLTLSEKTV 262
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 637 QenlhdQVQEQKAHLRAAQDRVLSLETSVN-ELNSQLNESKEKVSQL---DIQIK 687
Cdd:PRK11281 263 Q-----EAQSQDEAARIQANPLVAQELEINlQLSQRLLKATEKLNTLtqqNLRVK 312
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
870-1385 |
4.98e-06 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 51.22 E-value: 4.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 870 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK--ENQKGKAAILDLEKTCKELKHQLQVQM 947
Cdd:PRK03918 189 ENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEieELEKELESLEGSKRKLEEKIRELEERI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 948 ENTLKEQKELKKSLE--KEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 1025
Cdd:PRK03918 269 EELKKEIEELEEKVKelKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLK 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1026 IAVLQKTELEnklqqqltqaaqELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQdlKSVEEKLSLAQEDL 1105
Cdd:PRK03918 349 ELEKRLEELE------------ERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAK--EEIEEEISKITARI 414
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1106 ISNRNQIGNQNKLIQELKTAKATLEQdsakkeqqlqerCKALQDIQKEKSLKEK---ELVNEKSKLAEIEEIKCRQEKEI 1182
Cdd:PRK03918 415 GELKKEIKELKKAIEELKKAKGKCPV------------CGRELTEEHRKELLEEytaELKRIEKELKEIEEKERKLRKEL 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1183 TKLNEELKSHKlesiKEITNLKDAKQLL-IQQKLELQGKADSLKAAVEQEKRNQQILKdqvkkeeeelkkefiekeakLH 1261
Cdd:PRK03918 483 RELEKVLKKES----ELIKLKELAEQLKeLEEKLKKYNLEELEKKAEEYEKLKEKLIK--------------------LK 538
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1262 SEIKEKEVGMKKHEENEAKLTmqitALNENLGTVKKEWQSSQRRVSELE-KQTDDLRGEIAVLEA------TVQNNQDER 1334
Cdd:PRK03918 539 GEIKSLKKELEKLEELKKKLA----ELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPfyneylELKDAEKEL 614
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1335 RALLERclkgegeIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1385
Cdd:PRK03918 615 EREEKE-------LKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSE 658
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1049-1302 |
5.50e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 50.53 E-value: 5.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1049 LAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKAT 1128
Cdd:COG4942 15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1129 LEQDSAKKEQQLQERCKALQDIQKEKSLkeKELVNEKSKLAEIeeikcRQEKEITKLNEELKshklesiKEITNLKDAKQ 1208
Cdd:COG4942 95 LRAELEAQKEELAELLRALYRLGRQPPL--ALLLSPEDFLDAV-----RRLQYLKYLAPARR-------EQAEELRADLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1209 LLIQQKLELQGKADSLKAAVEQEKRNQQILKDQvkkeeeelKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITAL 1288
Cdd:COG4942 161 ELAALRAELEAERAELEALLAELEEERAALEAL--------KAERQKLLARLEKELAELAAELAELQQEAEELEALIARL 232
|
250
....*....|....
gi 767975501 1289 NENLGTVKKEWQSS 1302
Cdd:COG4942 233 EAEAAAAAERTPAA 246
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
130-918 |
5.57e-06 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 51.27 E-value: 5.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 130 LRQEVQDLQASLKEEKwyseelkkelekyqglqqqeakpdgLVTDSSAELQSLEQQLEEaqtenfnikqmkdlfeqkaaQ 209
Cdd:pfam15921 108 LRQSVIDLQTKLQEMQ-------------------------MERDAMADIRRRESQSQE--------------------D 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 210 LATEIADIKSKYDEERSLREaaeqkvtrltEELNKEATVIQDLKTELLQRPGIedvavlkkeLVQVQTLMDNMtleRERE 289
Cdd:pfam15921 143 LRNQLQNTVHELEAAKCLKE----------DMLEDSNTQIEQLRKMMLSHEGV---------LQEIRSILVDF---EEAS 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 290 SEKLKDECKKLQSQYASSEATISQLRSELakgPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE 369
Cdd:pfam15921 201 GKKIYEHDSMSTMHFRSLGSAISKILREL---DTEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEHE 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 370 -------ESVSKKNIQATLHQKDLDCQQLQSR---------LSASETSLHRIHVELSekgEATQKLKEELSEVETKYQHL 433
Cdd:pfam15921 278 veitgltEKASSARSQANSIQSQLEIIQEQARnqnsmymrqLSDLESTVSQLRSELR---EAKRMYEDKIEELEKQLVLA 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 434 KAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG---EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 510
Cdd:pfam15921 355 NSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSlekEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEAL 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 511 LKekvTNSTELQHQLDKTKQQ---HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLqkSKENISLLEKE 587
Cdd:pfam15921 435 LK---AMKSECQGQMERQMAAiqgKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTV--SDLTASLQEKE 509
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 588 REDLYAKIQAGEGETAVLNQLQEKNHTLQE-----QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 662
Cdd:pfam15921 510 RAIEATNAEITKLRSRVDLKLQELQHLKNEgdhlrNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQ 589
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 663 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEaaktAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDK 742
Cdd:pfam15921 590 VEKAQLEKEINDRRLELQEFKILKDKKDAKIRELE----ARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTS 665
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 743 QehcSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 822
Cdd:pfam15921 666 R---NELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQ 742
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 823 VSStrldLQKKSEALEsikQKLTKQEEEKKILKQDFETLSQEtkiqheelnnrIQTTVTELQKVKMEKEALMTELSTVKD 902
Cdd:pfam15921 743 IDA----LQSKIQFLE---EAMTNANKEKHFLKEEKNKLSQE-----------LSTVATEKNKMAGELEVLRSQERRLKE 804
|
810
....*....|....*.
gi 767975501 903 KLSKVSDSLKNSKSEF 918
Cdd:pfam15921 805 KVANMEVALDKASLQF 820
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
282-686 |
5.83e-06 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 51.11 E-value: 5.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 282 MTLERERESEKLKDECKKLQSQYAS-SEATISQLRSELAKGPQEVAVYVQELQKLKSSV-------NELTQKNQTLTENL 353
Cdd:PRK04863 244 MTLEAIRVTQSDRDLFKHLITESTNyVAADYMRHANERRVHLEEALELRRELYTSRRQLaaeqyrlVEMARELAELNEAE 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 354 LKKEQDYTKLEEKHNeesvskKNIQATLHQKDLdcQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHL 433
Cdd:PRK04863 324 SDLEQDYQAASDHLN------LVQTALRQQEKI--ERYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDEL 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 434 K---AEFKQ---LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL 507
Cdd:PRK04863 396 KsqlADYQQaldVQQTRAIQYQQAVQALERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQF 475
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 508 EE--QLKEKVTNSTELQ--HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 583
Cdd:PRK04863 476 EQayQLVRKIAGEVSRSeaWDVARELLRRLREQRHLAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDE 555
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 584 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ---ENLHDQVQEQKAHLRAAQDRVLS 660
Cdd:PRK04863 556 LEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQdalARLREQSGEEFEDSQDVTEYMQQ 635
|
410 420
....*....|....*....|....*.
gi 767975501 661 LETSVNELNSQLNESKEKVSQLDIQI 686
Cdd:PRK04863 636 LLERERELTVERDELAARKQALDEEI 661
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
620-852 |
6.11e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 50.15 E-value: 6.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 620 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 699
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 700 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 779
Cdd:COG4942 99 LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 780 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEmekeivsstrlDLQKKSEALESIKQKLTKQEEEKK 852
Cdd:COG4942 179 LLAELEEERAALEALKAERQKLLARLEKELAELAAELA-----------ELQQEAEELEALIARLEAEAAAAA 240
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
408-780 |
7.12e-06 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 50.54 E-value: 7.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 408 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH--GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL 485
Cdd:COG4717 82 EAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLlqLLPLYQELEALEAELAELPERLEELEERLEELREL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 486 SsEKLMDKEQQVADLQLKLSRLEEQLkekvtnSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQ 565
Cdd:COG4717 162 E-EELEELEAELAELQEELEELLEQL------SLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEN 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 566 KIQNLEALLQKSKENISL---------------LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 630
Cdd:COG4717 235 ELEAAALEERLKEARLLLliaaallallglggsLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALE 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 631 ESHKQAQENLHDQVQ----EQKAHLRAAQDRVLSLETSVNELNS-----QLNESKEKVSQLDIQIKAKTELLLSAEAAKT 701
Cdd:COG4717 315 ELEEEELEELLAALGlppdLSPEELLELLDRIEELQELLREAEEleeelQLEELEQEIAALLAEAGVEDEEELRAALEQA 394
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 702 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDkqehcSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 780
Cdd:COG4717 395 EEYQELKEELEELEEQLEELLGELEELLEALDEEELEEEL-----EELEEELEELEEELEELREELAELEAELEQLEED 468
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
187-1014 |
7.79e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 50.91 E-value: 7.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 187 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVA 266
Cdd:PTZ00121 1090 DEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEA 1169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 267 VLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR-------SELAKGPQEVAVYVQELQKL-KSS 338
Cdd:PTZ00121 1170 RKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARkaedakkAEAVKKAEEAKKDAEEAKKAeEER 1249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 339 VNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKkniqatlhqkdldCQQLQSRLSASETSLHRIHVELSEKGEATQK 418
Cdd:PTZ00121 1250 NNEEIRKFEEARMAHFARRQAAIKAEEARKADELKK-------------AEEKKKADEAKKAEEKKKADEAKKKAEEAKK 1316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 419 LKEelseVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQlGEAHGRLKEQRQLSSEKLMDKEQQVA 498
Cdd:PTZ00121 1317 ADE----AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEK-AEAAEKKKEEAKKKADAAKKKAEEKK 1391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 499 DLQlKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSK 578
Cdd:PTZ00121 1392 KAD-EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAK 1470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 579 ENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNhtlQEQVTQLTEKLKnQSESHKQAQENLHDQVQEQKAHLRAAQDRV 658
Cdd:PTZ00121 1471 KADEAKKKAEEAKKADEAKKKAEEAKKKADEAKK---AAEAKKKADEAK-KAEEAKKADEAKKAEEAKKADEAKKAEEKK 1546
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 659 LSLETSVNElNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 738
Cdd:PTZ00121 1547 KADELKKAE-ELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEEL 1625
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 739 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKK--LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 816
Cdd:PTZ00121 1626 KKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAaeEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE 1705
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 817 EMEKEIVSSTRLDLQ-KKSEALESIK--QKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 893
Cdd:PTZ00121 1706 ELKKKEAEEKKKAEElKKAEEENKIKaeEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEEL 1785
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 894 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTckelkhqlqvqMENTLKEQKELKKSLEKEKEASHQLKL 973
Cdd:PTZ00121 1786 DEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSKEM-----------EDSAIKEVADSKNMQLEEADAFEKHKF 1854
|
810 820 830 840
....*....|....*....|....*....|....*....|.
gi 767975501 974 ELNSMQEqliQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 1014
Cdd:PTZ00121 1855 NKNNENG---EDGNKEADFNKEKDLKEDDEEEIEEADEIEK 1892
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
229-778 |
7.97e-06 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 50.67 E-value: 7.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 229 EAAEQKVTRLTEELNKEATVIQDLKTELlqRPGIEDVAVLKKELVQVQTLMDNMTLERERES------EKLKDECKKLQS 302
Cdd:PRK01156 165 ERNYDKLKDVIDMLRAEISNIDYLEEKL--KSSNLELENIKKQIADDEKSHSITLKEIERLSieynnaMDDYNNLKSALN 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 303 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 382
Cdd:PRK01156 243 ELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEIN 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 383 QKDLDCQQLqsrlsASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 462
Cdd:PRK01156 323 KYHAIIKKL-----SVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEIL 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 463 SKLLETERQlgeahgrLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ----LDKTKQQHQEQQAL 538
Cdd:PRK01156 398 KIQEIDPDA-------IKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpVCGTTLGEEKSNHI 470
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 539 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK-SKENISLLEKER---EDLYAKIQAGEGETAVLNQLQEKNHT 614
Cdd:PRK01156 471 INHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYlESEEINKSINEYnkiESARADLEDIKIKINELKDKHDKYEE 550
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 615 LQEQVTQL-TEKLKNQSESHKQAQ--------ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQ 685
Cdd:PRK01156 551 IKNRYKSLkLEDLDSKRTSWLNALavislidiETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANN 630
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 686 IKAKTELLLSAEAAKTAQRADLQNH------LDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 759
Cdd:PRK01156 631 LNNKYNEIQENKILIEKLRGKIDNYkkqiaeIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTR 710
|
570
....*....|....*....
gi 767975501 760 YLSLEQKTEELEGQIKKLE 778
Cdd:PRK01156 711 INELSDRINDINETLESMK 729
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
568-1036 |
9.19e-06 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 50.15 E-value: 9.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 568 QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVtqltEKLKNQSESHKQAQENLHDQVQEQ 647
Cdd:COG4717 53 KEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEEL----EELEAELEELREELEKLEKLLQLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 648 KAHLRAAQdrvlsLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNK 727
Cdd:COG4717 129 PLYQELEA-----LEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 728 ITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 807
Cdd:COG4717 204 LQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 808 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIkqkltkQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKV- 886
Cdd:COG4717 284 GLLALLFLLLAREKASLGKEAEELQALPALEEL------EEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAe 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 887 KMEKEALMTELSTVKDKLSKVSDSlkNSKSEFEKenqkgKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE-- 964
Cdd:COG4717 358 ELEEELQLEELEQEIAALLAEAGV--EDEEELRA-----ALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEel 430
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767975501 965 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL--QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 1036
Cdd:COG4717 431 EEELEELEEELEELEEELEELREELAELEAELEQLeeDGELAELLQELEELKAELRELAEEWAALKLALELLEE 504
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
882-1384 |
1.02e-05 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 50.11 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 882 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQ---------MENTLK 952
Cdd:pfam05483 86 EAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENnatrhlcnlLKETCA 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 953 EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ-----QLQGNINELKQSSEQKKKQIEALQGELKIA 1027
Cdd:pfam05483 166 RSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARlemhfKLKEDHEKIQHLEEEYKKEINDKEKQVSLL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1028 VLQKTELENKLQQQL---TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1104
Cdd:pfam05483 246 LIQITEKENKMKDLTfllEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKT 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1105 LIS----NRNQIGNQNK-------LIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELvNEKSKLAEIEE 1173
Cdd:pfam05483 326 ICQlteeKEAQMEELNKakaahsfVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSEL-EEMTKFKNNKE 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1174 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF 1253
Cdd:pfam05483 405 VELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK 484
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1254 IEKEaKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE 1333
Cdd:pfam05483 485 LKNI-ELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975501 1334 RRALLER-----------CLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHT 1384
Cdd:pfam05483 564 VKCKLDKseenarsieyeVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGS 625
|
|
| FYVE_WDFY2 |
cd15757 |
FYVE domain found in WD40 repeat and FYVE domain-containing protein 2 (WDFY2); WDFY2, also ... |
1409-1447 |
1.09e-05 |
|
FYVE domain found in WD40 repeat and FYVE domain-containing protein 2 (WDFY2); WDFY2, also termed zinc finger FYVE domain-containing protein 22, or ProF (propeller-FYVE protein), is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) binding protein that is localized to a distinct subset of early endosomes close to the plasma membrane. It interacts preferentially with endogenous serine/threonine kinase Akt2, but not Akt1, and plays a specific role in modulating signaling through Akt downstream of the interaction of this kinase with the endosomal proteins APPL (adaptor protein containing PH domain, PTB domain, and leucine zipper motif). In addition to Akt, WDFY2 serves as a binding partner for protein kinase C, zeta (PRKCZ), and its substrate vesicle-associated membrane protein 2 (VAMP2), and is involved in vesicle cycling in various secretory pathways. Moreover, Silencing of WDFY2 by siRNA produces a strong inhibition of endocytosis. WDFY2 contains WD40 motifs and a FYVE domain.
Pssm-ID: 277296 [Multi-domain] Cd Length: 70 Bit Score: 44.67 E-value: 1.09e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 767975501 1409 VTVRRHHCRQCGNIFCAECSAKNALTP--SSKKPVRVCDAC 1447
Cdd:cd15757 29 IGLRQHHCRKCGKAVCGKCSSKRSTIPlmGFEFEVRVCDSC 69
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
301-1031 |
1.11e-05 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 50.35 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 301 QSQYASSEATISQLRSELAK--GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKhneesvskKNIQ 378
Cdd:TIGR00618 188 KKKSLHGKAELLTLRSQLLTlcTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQ--------LKKQ 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 379 ATLHQKDLDCQQLQSRLSASETSLHRIhvELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI 458
Cdd:TIGR00618 260 QLLKQLRARIEELRAQEAVLEETQERI--NRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQ 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 459 NQLHSKLlETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ--LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 536
Cdd:TIGR00618 338 SSIEEQR-RLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQhiHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRT 416
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 537 ALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLealLQKSKENISLLEKEREDLYAKIQAgEGETAVLNQLQEKNHTLQ 616
Cdd:TIGR00618 417 SAFRDLQGQLAHAKKQQELQQRYAELCAAAITCT---AQCEKLEKIHLQESAQSLKEREQQ-LQTKEQIHLQETRKKAVV 492
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 617 EQVTQL---TEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLdiqiKAKTELL 693
Cdd:TIGR00618 493 LARLLElqeEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASL----KEQMQEI 568
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 694 LSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKittQLDQVTAKLQDKQEHCSQLESHLKEYKekyLSLEQKTEELEGQ 773
Cdd:TIGR00618 569 QQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEK---LSEAEDMLACEQHALLRKLQPEQDLQD---VRLHLQQCSQELA 642
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 774 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKI 853
Cdd:TIGR00618 643 LKLTALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNE 722
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 854 LKQDFETLSQETKIQHEELNNRIQTTVTELQKVkmekealmtelstvkdklskvsdsLKNSKSEFEKENQKGKAAILDLE 933
Cdd:TIGR00618 723 IENASSSLGSDLAAREDALNQSLKELMHQARTV------------------------LKARTEAHFNNNEEVTAALQTGA 778
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 934 KTcKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNIN-ELKQSSEQ 1012
Cdd:TIGR00618 779 EL-SHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEIThQLLKYEEC 857
|
730
....*....|....*....
gi 767975501 1013 KKKQIEALQGELKIAVLQK 1031
Cdd:TIGR00618 858 SKQLAQLTQEQAKIIQLSD 876
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
133-964 |
1.37e-05 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 50.05 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 133 EVQDLQASLKEEKWYSEELKKELE--KYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQL 210
Cdd:TIGR00606 266 KLDNEIKALKSRKKQMEKDNSELElkMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTEL 345
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 211 ATEIADIKSKYD--EERSLREAAEQKVTRLTEELNkeatviqDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 288
Cdd:TIGR00606 346 LVEQGRLQLQADrhQEHIRARDSLIQSLATRLELD-------GFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQ 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 289 ESEKLKDE-CKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTenllKKEQDYTKLEEKH 367
Cdd:TIGR00606 419 SKERLKQEqADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELR----KAERELSKAEKNS 494
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 368 NEESVSKKNIQATLHQKDLD-----CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEF---KQ 439
Cdd:TIGR00606 495 LTETLKKEVKSLQNEKADLDrklrkLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFpnkKQ 574
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 440 LQQQREEKEQHGLQLQSEINQLHSKLLETER---QLGEAHGRLKEQRQLSSEKLMDKeQQVADLQLKLSRLEEQLKEKVT 516
Cdd:TIGR00606 575 LEDWLHSKSKEINQTRDRLAKLNKELASLEQnknHINNELESKEEQLSSYEDKLFDV-CGSQDEESDLERLKEEIEKSSK 653
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 517 NSTELQ----------HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 586
Cdd:TIGR00606 654 QRAMLAgatavysqfiTQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAP 733
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 587 EREDLYAKIQAGegetavLNQLQEKNHTLQEQVTQLTEKLKNQSEshkqaqenlhdQVQEQKAHLRAAQDrVLSLETSVN 666
Cdd:TIGR00606 734 GRQSIIDLKEKE------IPELRNKLQKVNRDIQRLKNDIEEQET-----------LLGTIMPEEESAKV-CLTDVTIME 795
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 667 ELNSQLNESKEKVSQLdiqikaktelllsaeaAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHC 746
Cdd:TIGR00606 796 RFQMELKDVERKIAQQ----------------AAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQI 859
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 747 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEadslevKASKEQALQDLQQQRQLNTDLELrATELSKQLEMEKEIVSST 826
Cdd:TIGR00606 860 QHLKSKTNELKSEKLQIGTNLQRRQQFEEQLV------ELSTEVQSLIREIKDAKEQDSPL-ETFLEKDQQEKEELISSK 932
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 827 RLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSK 906
Cdd:TIGR00606 933 ETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKI 1012
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 907 VSDSLKNSKSEFEKENQkgkaaildLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 964
Cdd:TIGR00606 1013 QERWLQDNLTLRKRENE--------LKEVEEELKQHLKEMGQMQVLQMKQEHQKLEEN 1062
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
783-1161 |
1.56e-05 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 49.68 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 783 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEmekeivsstRLdlqkksealesikqkltKQEEEKKILKQDFETLS 862
Cdd:TIGR02169 167 EFDRKKEKALEELEEVEENIERLDLIIDEKRQQLE---------RL-----------------RREREKAERYQALLKEK 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 863 QETKIQheELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 942
Cdd:TIGR02169 221 REYEGY--ELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGE 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 943 LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQG 1022
Cdd:TIGR02169 299 LEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDK 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1023 ELKIAVlqktelenklqqqltqaaQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQ 1102
Cdd:TIGR02169 379 EFAETR------------------DELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELE 440
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1103 EDLISNRNQIgnqNKLIQELKTAKATLEqdsaKKEQQLQERCKALQDIQKEKSLKEKEL 1161
Cdd:TIGR02169 441 EEKEDKALEI---KKQEWKLEQLAADLS----KYEQELYDLKEEYDRVEKELSKLQREL 492
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
287-864 |
1.57e-05 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 49.84 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 287 ERESEKLKDECKKLQS---QYASSEATISQLRSELAKGPQEVAVYVQELQK-LKSSVNELTQKNQTLTENLLKKEQDYTK 362
Cdd:pfam12128 247 QQEFNTLESAELRLSHlhfGYKSDETLIASRQEERQETSAELNQLLRTLDDqWKEKRDELNGELSAADAAVAKDRSELEA 326
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 363 LEEKH----NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE-KGEATQKLKEELSEVETKYQHLK-AE 436
Cdd:pfam12128 327 LEDQHgaflDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRrRSKIKEQNNRDIAGIKDKLAKIReAR 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 437 FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLK---EQRQLSSEKLMDKEQQvadlQLKLSRLEEQLKE 513
Cdd:pfam12128 407 DRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKlrlNQATATPELLLQLENF----DERIERAREEQEA 482
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 514 KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIgdkDQKIQNLEALLQKS----KENIS-LLEKE- 587
Cdd:pfam12128 483 ANAEVERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQL---FPQAGTLLHFLRKEapdwEQSIGkVISPEl 559
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 588 --REDLYAKIQAGE--------GETAVLNQLQ-----EKNHTLQEQVTQLTEKLKNQSESHKQA---------------- 636
Cdd:pfam12128 560 lhRTDLDPEVWDGSvggelnlyGVKLDLKRIDvpewaASEEELRERLDKAEEALQSAREKQAAAeeqlvqangelekasr 639
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 637 ----------------------QENLHDQVQEQ-KAHLRAAQDRVLSLETSVNELNSQLNESKEK--------------- 678
Cdd:pfam12128 640 eetfartalknarldlrrlfdeKQSEKDKKNKAlAERKDSANERLNSLEAQLKQLDKKHQAWLEEqkeqkreartekqay 719
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 679 ----VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 754
Cdd:pfam12128 720 wqvvEGALDAQLALLKAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRYFD 799
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 755 EYKEKYLS-----------LEQKTEELEGQIKKLEADSlevkaskEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 823
Cdd:pfam12128 800 WYQETWLQrrprlatqlsnIERAISELQQQLARLIADT-------KLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKL 872
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 767975501 824 SSTRLDlQKKSEALESIKQKLTKQEEEKKILKQDFETLSQE 864
Cdd:pfam12128 873 ATLKED-ANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKY 912
|
|
| ClpA |
COG0542 |
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ... |
404-516 |
1.86e-05 |
|
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 49.31 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 404 RIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEK-EQHGLQLQSEINQLHSKLlETERQLGEAHGRLKEQ 482
Cdd:COG0542 401 RVRMEIDSKPEELDELERRLEQLEIEKEALKKEQDEASFERLAElRDELAELEEELEALKARW-EAEKELIEEIQELKEE 479
|
90 100 110
....*....|....*....|....*....|....
gi 767975501 483 RQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 516
Cdd:COG0542 480 LEQRYGKIPELEKELAELEEELAELAPLLREEVT 513
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
572-786 |
1.98e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.61 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 572 ALLQKSKENISLLEKEREDLYAKIQAGEGEtavLNQLQEKNHTLQEQVTQLTEKLKNQSEshkqaqenlhdQVQEQKAHL 651
Cdd:COG4942 13 LAAAAQADAAAEAEAELEQLQQEIAELEKE---LAALKKEEKALLKQLAALERRIAALAR-----------RIRALEQEL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 652 RAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI-----KAKTELLLSAEAAKTA------------QRADLQNHLDTA 714
Cdd:COG4942 79 AALEAELAELEKEIAELRAELEAQKEELAELLRALyrlgrQPPLALLLSPEDFLDAvrrlqylkylapARREQAEELRAD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975501 715 QNALQDKQQELNKITTQLDQVTAKLQDKQEhcsQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 786
Cdd:COG4942 159 LAELAALRAELEAERAELEALLAELEEERA---ALEALKAERQKLLARLEKELAELAAELAELQQEAEELEA 227
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
439-683 |
2.05e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 49.24 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 439 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQL---GEAHG--RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLke 513
Cdd:COG3206 165 NLELRREEARKALEFLEEQLPELRKELEEAEAALeefRQKNGlvDLSEEAKLLLQQLSELESQLAEARAELAEAEARL-- 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 514 kvtNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKEnisLLEKEREDLYA 593
Cdd:COG3206 243 ---AALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRA---QLQQEAQRILA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 594 KIQagegetAVLNQLQEKNHTLQEQVTQLTEKLKNQSEshkqaqenLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 673
Cdd:COG3206 317 SLE------AELEALQAREASLQAQLAQLEARLAELPE--------LEAELRRLEREVEVARELYESLLQRLEEARLAEA 382
|
250
....*....|
gi 767975501 674 ESKEKVSQLD 683
Cdd:COG3206 383 LTVGNVRVID 392
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
574-1216 |
2.15e-05 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 49.20 E-value: 2.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 574 LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLT---EKLKNQSESHKQAQENLhdQVQEQKAH 650
Cdd:TIGR00618 217 YHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRariEELRAQEAVLEETQERI--NRARKAAP 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 651 LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAktellLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITT 730
Cdd:TIGR00618 295 LAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAA-----HVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIRE 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 731 QLDQVTAKLQdkqeHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT 810
Cdd:TIGR00618 370 ISCQQHTLTQ----HIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAA 445
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 811 ELSKQLEMEKeivsstrldlQKKSEALESikQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK 890
Cdd:TIGR00618 446 AITCTAQCEK----------LEKIHLQES--AQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHP 513
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 891 EALMTELSTVKDKLSKVsDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 970
Cdd:TIGR00618 514 NPARQDIDNPGPLTRRM-QRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNI 592
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 971 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEla 1050
Cdd:TIGR00618 593 TVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIRVL-- 670
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1051 aEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEdlisnrnQIGNQNKLIQELKTAKATLE 1130
Cdd:TIGR00618 671 -PKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNE-------IENASSSLGSDLAAREDALN 742
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1131 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIE---EIKCRQEKEITKLNEELKSHKLESIKEITNLKDAK 1207
Cdd:TIGR00618 743 QSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAaeiQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQ 822
|
....*....
gi 767975501 1208 QLLIQQKLE 1216
Cdd:TIGR00618 823 CETLVQEEE 831
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
981-1227 |
3.00e-05 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 48.29 E-value: 3.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 981 QLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAvlqktelenklqqqltqaAQELAAEKEKISVLQ 1060
Cdd:COG3883 17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEAL------------------QAEIDKLQAEIAEAE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1061 NNYEKSQETFKQLQSDFY--GRESELLATRQDLKSVEEKLslaqeDLISNRNQI-GNQNKLIQELKTAKATLEQDSAKKE 1137
Cdd:COG3883 79 AEIEERREELGERARALYrsGGSVSYLDVLLGSESFSDFL-----DRLSALSKIaDADADLLEELKADKAELEAKKAELE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1138 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1217
Cdd:COG3883 154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAA 233
|
250
....*....|
gi 767975501 1218 QGKADSLKAA 1227
Cdd:COG3883 234 AAAAAAAAAA 243
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
634-787 |
3.72e-05 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 46.84 E-value: 3.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 634 KQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQraDLQNHLDT 713
Cdd:COG1579 23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYE--ALQKEIES 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767975501 714 AQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKylsLEQKTEELEGQIKKLEADSLEVKAS 787
Cdd:COG1579 101 LKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAE---LDEELAELEAELEELEAEREELAAK 171
|
|
| FYVE1_Vac1p_like |
cd15761 |
FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also ... |
1391-1448 |
4.39e-05 |
|
FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; Vac1p, also termed vacuolar segregation protein Pep7p, or carboxypeptidase Y-deficient protein 7, or vacuolar protein sorting-associated protein 19 (Vps19p), or vacuolar protein-targeting protein 19, is a phosphatidylinositol 3-phosphate (PtdIns3P or PI3P)-binding protein that interacts with a Rab GTPase, GTP-bound form of Vps21p, and a Sec1p homologue, Vps45p, to facilitate Vps45p-dependent vesicle-mediated vacuolar protein sorting. It also acts as a novel regulator of vesicle docking and/or fusion at the endosome and functions in vesicle-mediated transport of Golgi precursor carboxypeptidase Y (CPY), protease A (PrA), protease B (PrB), but not alkaline phosphatase (ALP) from the trans-Golgi network-like compartment (TGN) to the endosome. Vac1p contains an N-terminal classical TFIIIA-like zinc finger, two putative zinc-binding FYVE fingers, and a C-terminal coiled coil region. The family corresponds to the first FYVE domain, which resembles the FYVE-related domain as it has an altered sequence in the basic ligand binding patch.
Pssm-ID: 277300 Cd Length: 76 Bit Score: 43.03 E-value: 4.39e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 1391 WAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAE-C--------SAKNalTPSSKKPVRVCDACF 1448
Cdd:cd15761 4 WKKPSGKSRCSECGKTLNKKNGIVNCRKCGELFCNEhCrnriklnnSAEY--DPKNGKWCRCCEKCF 68
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
132-529 |
4.52e-05 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 48.14 E-value: 4.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 132 QEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQL- 210
Cdd:PRK03918 276 EELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLe 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 211 -----ATEIADIKSKYDEERSLR---------------EAAEQKVTRLTEELNKEATVIQDLKTELLQRPgiEDVAVLKK 270
Cdd:PRK03918 356 eleerHELYEEAKAKKEELERLKkrltgltpeklekelEELEKAKEEIEEEISKITARIGELKKEIKELK--KAIEELKK 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 271 ELVQVQTLMDNMTLERERE-SEKLKDECKKLQSQYASSEATISQLRSELAK------GPQEVAVYVQELQKLKSSVNELT 343
Cdd:PRK03918 434 AKGKCPVCGRELTEEHRKElLEEYTAELKRIEKELKEIEEKERKLRKELRElekvlkKESELIKLKELAEQLKELEEKLK 513
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 344 QKNqtlTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDL---DCQQLQSRLSASETSLHRIHVELSEKG-EATQKL 419
Cdd:PRK03918 514 KYN---LEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEElkkKLAELEKKLDELEEELAELLKELEELGfESVEEL 590
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 420 KEELSEVETKYQHLkAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE--------KLM 491
Cdd:PRK03918 591 EERLKELEPFYNEY-LELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEeeyeelreEYL 669
|
410 420 430
....*....|....*....|....*....|....*...
gi 767975501 492 DKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK 529
Cdd:PRK03918 670 ELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE 707
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
285-514 |
5.20e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 47.45 E-value: 5.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 285 ERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDytkLE 364
Cdd:COG4942 24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE---LE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 365 EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR 444
Cdd:COG4942 101 AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALL 180
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 445 EEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEqrqlsseklmdKEQQVADLQLKLSRLEEQLKEK 514
Cdd:COG4942 181 AELEEERAALEALKAERQKLLARLEKELAELAAELAE-----------LQQEAEELEALIARLEAEAAAA 239
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
661-914 |
7.13e-05 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 47.32 E-value: 7.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 661 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 740
Cdd:PHA02562 172 NKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIE 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 741 DkqehcsqLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL--EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 818
Cdd:PHA02562 252 D-------PSAALNKLNTAAAKIKSKIEQFQKVIKMYEKGGVcpTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDE 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 819 EKEIVSSTRlDLQKKSEAL----ESIKQKLTKQEEEKKILKQDFETLSQETKIQHEElnnrIQTTVTELQKVKMEKealm 894
Cdd:PHA02562 325 LEEIMDEFN-EQSKKLLELknkiSTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEE----LAKLQDELDKIVKTK---- 395
|
250 260
....*....|....*....|
gi 767975501 895 TELSTVKDKLSKVSDSLKNS 914
Cdd:PHA02562 396 SELVKEKYHRGIVTDLLKDS 415
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
417-1073 |
7.26e-05 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 47.66 E-value: 7.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 417 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLletERQLGEAHGRLKEQRQLSSEKLMDKEQQ 496
Cdd:TIGR00618 197 ELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYL---TQKREAQEEQLKKQQLLKQLRARIEELR 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 497 VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQK 576
Cdd:TIGR00618 274 AQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQ 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 577 SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQA----------QENLHDQVQE 646
Cdd:TIGR00618 354 EIHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDtrtsafrdlqGQLAHAKKQQ 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 647 QKAHLRAAQDRVLSLETSVNEL--NSQLNESKEKVSQLDIQIKAKtELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE 724
Cdd:TIGR00618 434 ELQQRYAELCAAAITCTAQCEKleKIHLQESAQSLKEREQQLQTK-EQIHLQETRKKAVVLARLLELQEEPCPLCGSCIH 512
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 725 LNKITTQLD-----------------QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKAS 787
Cdd:TIGR00618 513 PNPARQDIDnpgpltrrmqrgeqtyaQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNI 592
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 788 KEQALQDLQQQRQLNTDLELRATELSKQLEmEKEIVSSTRLDLQKKSEALEsiKQKLTKQEEEKKILKQDFETLSQETKI 867
Cdd:TIGR00618 593 TVRLQDLTEKLSEAEDMLACEQHALLRKLQ-PEQDLQDVRLHLQQCSQELA--LKLTALHALQLTLTQERVREHALSIRV 669
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 868 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHqlqvqm 947
Cdd:TIGR00618 670 LPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQ------ 743
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 948 enTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLqgnINELKQSSEQKKKQIEALQGELKIA 1027
Cdd:TIGR00618 744 --SLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRL---REEDTHLLKTLEAEIGQEIPSDEDI 818
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 767975501 1028 VLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1073
Cdd:TIGR00618 819 LNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQL 864
|
|
| PTZ00303 |
PTZ00303 |
phosphatidylinositol kinase; Provisional |
1367-1452 |
7.54e-05 |
|
phosphatidylinositol kinase; Provisional
Pssm-ID: 140324 [Multi-domain] Cd Length: 1374 Bit Score: 47.39 E-value: 7.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1367 AAVQELGRENQSLQIKHTQAL-NRKWAEDNEVQN-CMACGKGF-----SVTVRRHHCRQCGNIFCAECSAKNA------- 1432
Cdd:PTZ00303 428 ATVGGVAEENELNTFGLTKLLhNPSWQKDDESSDsCPSCGRAFislsrPLGTRAHHCRSCGIRLCVFCITKRAhysfakl 507
|
90 100
....*....|....*....|...
gi 767975501 1433 LTPSSKKPVR---VCDACFNDLQ 1452
Cdd:PTZ00303 508 AKPGSSDEAEerlVCDTCYKEYE 530
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
117-349 |
8.41e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 47.32 E-value: 8.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 117 ESNLALKRDD----VTLLRQEVQDLQASLkeekwysEELKKELEKYQgLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE 192
Cdd:COG3206 163 EQNLELRREEarkaLEFLEEQLPELRKEL-------EEAEAALEEFR-QKNGLVDLSEEAKLLLQQLSELESQLAEARAE 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 193 NFNIKQMKDLFEQKAAQLATEIADIKSK--YDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELlqrpgiedvAVLKK 270
Cdd:COG3206 235 LAEAEARLAALRAQLGSGPDALPELLQSpvIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQI---------AALRA 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 271 ELVQvqtlmdnmtlERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP---QEVAVYVQELQKLKSSVNELTQKNQ 347
Cdd:COG3206 306 QLQQ----------EAQRILASLEAELEALQAREASLQAQLAQLEARLAELPeleAELRRLEREVEVARELYESLLQRLE 375
|
..
gi 767975501 348 TL 349
Cdd:COG3206 376 EA 377
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
826-1153 |
8.45e-05 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 47.21 E-value: 8.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 826 TRLDLQKKSEALESIKQkltkQEEEKKILKQDFE-TLSQETKIQH-----EELNNRIQTTVTELQKVKMEKEALMTELST 899
Cdd:PRK11281 37 TEADVQAQLDALNKQKL----LEAEDKLVQQDLEqTLALLDKIDRqkeetEQLKQQLAQAPAKLRQAQAELEALKDDNDE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 900 VK-------------DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKH---QLQvQMENTLKEQKELKKSLEK 963
Cdd:PRK11281 113 ETretlstlslrqleSRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYAnsqRLQ-QIRNLLKGGKVGGKALRP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 964 EKEASHQLKLEL----NSMQEQLIQAQNTL---------------KQNEKEEQQLQGNINE--LKQSSEQKKKQIEA--- 1019
Cdd:PRK11281 192 SQRVLLQAEQALlnaqNDLQRKSLEGNTQLqdllqkqrdyltariQRLEHQLQLLQEAINSkrLTLSEKTVQEAQSQdea 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1020 --------LQGELKI------AVLQKTELENKLQQQLTQAAQEL-------AAEKEKISVLQNNYEKSQETFKQLQSDFY 1078
Cdd:PRK11281 272 ariqanplVAQELEInlqlsqRLLKATEKLNTLTQQNLRVKNWLdrltqseRNIKEQISVLKGSLLLSRILYQQQQALPS 351
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 1079 GRESELLATR-QDLKsveeklsLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKK--EQQLQERCKALQDIQKE 1153
Cdd:PRK11281 352 ADLIEGLADRiADLR-------LEQFEINQQRDALFQPDAYIDKLEAGHKSEVTDEVRDalLQLLDERRELLDQLNKQ 422
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
130-744 |
8.74e-05 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 47.26 E-value: 8.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 130 LRQEVQDLQASLKEEKwYSEELKKELEKYQGLQ-QQEAKPDGLVTDSSAELQSLEQQLEEAQtenfnikQMKDLFEQKAA 208
Cdd:PRK04863 518 LRMRLSELEQRLRQQQ-RAERLLAEFCKRLGKNlDDEDELEQLQEELEARLESLSESVSEAR-------ERRMALRQQLE 589
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 209 QLATEIADIKSKYDEERslreAAEQKVTRLTEELNKEATVIQDLkTELLQrpgieDVAVLKKELVQVQTlmdnmtlERER 288
Cdd:PRK04863 590 QLQARIQRLAARAPAWL----AAQDALARLREQSGEEFEDSQDV-TEYMQ-----QLLERERELTVERD-------ELAA 652
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 289 ESEKLKDECKKLQSQYASSEATISQLRSEL----------------------AKGPQEVAVYVQELqklkSSVNELTQKN 346
Cdd:PRK04863 653 RKQALDEEIERLSQPGGSEDPRLNALAERFggvllseiyddvsledapyfsaLYGPARHAIVVPDL----SDAAEQLAGL 728
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 347 QTLTENLLKKEQDYTKLEEkhneeSVSKkniqATLHQKDLdCQQL---QSRLS-----------ASETSLHRIHVELSEK 412
Cdd:PRK04863 729 EDCPEDLYLIEGDPDSFDD-----SVFS----VEELEKAV-VVKIadrQWRYSrfpevplfgraAREKRIEQLRAEREEL 798
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 413 GEATQKLKEELSEVETKYQHLK----------------AEFKQLQQQREEKEQHGLQLQSEINQLHSKLleteRQLGEAH 476
Cdd:PRK04863 799 AERYATLSFDVQKLQRLHQAFSrfigshlavafeadpeAELRQLNRRRVELERALADHESQEQQQRSQL----EQAKEGL 874
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 477 GRLkeQRQLSSEKLMDKEqqvaDLQLKLSRLEEQLKEkvtnstelqhqldktkqqhqeqqalqqsttakLREAQNDleqv 556
Cdd:PRK04863 875 SAL--NRLLPRLNLLADE----TLADRVEEIREQLDE--------------------------------AEEAKRF---- 912
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 557 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL-QEKNH-------TLQEQVTQLTEKLKN 628
Cdd:PRK04863 913 VQQHGNALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVvQRRAHfsyedaaEMLAKNSDLNEKLRQ 992
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 629 QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAktelllSAEAAKTAQRADLQ 708
Cdd:PRK04863 993 RLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQDLGVPADS------GAEERARARRDELH 1066
|
650 660 670
....*....|....*....|....*....|....*.
gi 767975501 709 NHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 744
Cdd:PRK04863 1067 ARLSANRSRRNQLEKQLTFCEAEMDNLTKKLRKLER 1102
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
116-383 |
9.20e-05 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 47.22 E-value: 9.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 116 GESN---LALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGlVTDSSAELQSLEQQLEEAQTE 192
Cdd:COG4913 605 GFDNrakLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEID-VASAEREIAELEAELERLDAS 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 193 NFNIKQMkdlfEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEElnkeatvIQDLKTELLQRPGIEDVAvlkkel 272
Cdd:COG4913 684 SDDLAAL----EEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE-------LDELQDRLEAAEDLARLE------ 746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 273 vqVQTLMDNMtLERERESEKLKDECKKLQSQYASSEATISQLRSELAK------------------GPQEVAVYVQELQK 334
Cdd:COG4913 747 --LRALLEER-FAAALGDAVERELRENLEERIDALRARLNRAEEELERamrafnrewpaetadldaDLESLPEYLALLDR 823
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 767975501 335 LKssvneltqknqtlTENLLKKEQDYTKLEEKHNEESVSkkNIQATLHQ 383
Cdd:COG4913 824 LE-------------EDGLPEYEERFKELLNENSIEFVA--DLLSKLRR 857
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
290-789 |
1.11e-04 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 46.98 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 290 SEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNqtltENLLKKEQDYTKLEEKhne 369
Cdd:PRK03918 188 TENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELE----KELESLEGSKRKLEEK--- 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 370 esvsKKNIQATLHQKDLDCQQLQSRLSASEtslhrihvELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQR---EE 446
Cdd:PRK03918 261 ----IRELEERIEELKKEIEELEEKVKELK--------ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEIngiEE 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 447 KEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD 526
Cdd:PRK03918 329 RIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEIS 408
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 527 KTKQQHQEQQALQQSTTA---KLREAQNDLEQVLRQIGDKDQK--IQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE 601
Cdd:PRK03918 409 KITARIGELKKEIKELKKaieELKKAKGKCPVCGRELTEEHRKelLEEYTAELKRIEKELKEIEEKERKLRKELRELEKV 488
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 602 TAVLNQLQeKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS-------LETSVNELNSQLNE 674
Cdd:PRK03918 489 LKKESELI-KLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKelekleeLKKKLAELEKKLDE 567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 675 SKEKVSQLDIQIKA---KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLES 751
Cdd:PRK03918 568 LEEELAELLKELEElgfESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRK 647
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 767975501 752 HLKEYK-----EKYLSLEQKTEELEGQIKKLEADSLEVKASKE 789
Cdd:PRK03918 648 ELEELEkkyseEEYEELREEYLELSRELAGLRAELEELEKRRE 690
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
389-605 |
1.28e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 46.55 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 389 QQLQSRLSASETSLHRIHVELsekgeatQKLKEELSEVETKYQHLKAEFK--QLQQQREEKEQHGLQLQSEINQLHSKLL 466
Cdd:COG3206 164 QNLELRREEARKALEFLEEQL-------PELRKELEEAEAALEEFRQKNGlvDLSEEAKLLLQQLSELESQLAEARAELA 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 467 ETERQLGEAHGRLKEQRQ-----LSSEKLMDKEQQVADLQLKLSRLEE----------QLKEKVTN-STELQHQLDKTKQ 530
Cdd:COG3206 237 EAEARLAALRAQLGSGPDalpelLQSPVIQQLRAQLAELEAELAELSArytpnhpdviALRAQIAAlRAQLQQEAQRILA 316
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 531 QHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 605
Cdd:COG3206 317 SLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEALTVGNVRVI 391
|
|
| HOOK |
pfam05622 |
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ... |
130-585 |
1.30e-04 |
|
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 46.22 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 130 LRQEVQDLQ---ASLKEEKwysEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQK 206
Cdd:pfam05622 12 LAQRCHELDqqvSLLQEEK---NSLQQENKKLQERLDQLESGDDSGTPGGKKYLLLQKQLEQLQEENFRLETARDDYRIK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 207 AAQLATEIADIKSKYDEERSLREAA-----EQKVTRLT-EELNKEATVIQDLKTELlqrpgiEDVAVLKKelvQVQTLMD 280
Cdd:pfam05622 89 CEELEKEVLELQHRNEELTSLAEEAqalkdEMDILRESsDKVKKLEATVETYKKKL------EDLGDLRR---QVKLLEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 281 NMTLERERESEkLKDECKKLQSqyasseatisqLRSELakgpqevAVYVQELQKLKSSVNELTQKNQTLtenllkkEQDY 360
Cdd:pfam05622 160 RNAEYMQRTLQ-LEEELKKANA-----------LRGQL-------ETYKRQVQELHGKLSEESKKADKL-------EFEY 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 361 TKLEEKHNEESVSKKNIQA---TLHQ--KDLDCQQLQSRlsasetSLHRIHVELSEKGEATQKLKEEL--SEVETKYQHL 433
Cdd:pfam05622 214 KKLEEKLEALQKEKERLIIerdTLREtnEELRCAQLQQA------ELSQADALLSPSSDPGDNLAAEImpAEIREKLIRL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 434 KAEFKQLQQQREEKEQhglqlqseinqlhSKLLETERQLGEAHGR---LKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 510
Cdd:pfam05622 288 QHENKMLRLGQEGSYR-------------ERLTELQQLLEDANRRkneLETQNRLANQRILELQQQVEELQKALQEQGSK 354
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 511 LKEKVTNSTELQHQLDKTKQQHQEQQalqqsttaKLREAQNDLEQVLRQigDKDQKIQNLEALLQKSKENISLLE 585
Cdd:pfam05622 355 AEDSSLLKQKLEEHLEKLHEAQSELQ--------KKKEQIEELEPKQDS--NLAQKIDELQEALRKKDEDMKAME 419
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
421-857 |
1.37e-04 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 46.35 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 421 EELSEVETKYQH---LKAEFKQLQQQREEKEqhglqlqSEINQLHSKLLETERQLGEAhgrlKEQRQLSSEKLMDKEQQV 497
Cdd:pfam10174 272 EEIKQMEVYKSHskfMKNKIDQLKQELSKKE-------SELLALQTKLETLTNQNSDC----KQHIEVLKESLTAKEQRA 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 498 ADLQLKLSRLEEQLKEKvtnstelQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 577
Cdd:pfam10174 341 AILQTEVDALRLRLEEK-------ESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDK 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 578 KENISLLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHT---LQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRA 653
Cdd:pfam10174 414 DKQLAGLKERVKSLQTDSSNTDTALTTLEEaLSEKERIierLKEQREREDRERLEELESLKKENKDLKEKVSALQPELTE 493
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 654 AQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE-------LLLSAEAAKTAQRA--DLQNHLDTAQNALQDKQQE 724
Cdd:pfam10174 494 KESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEecsklenQLKKAHNAEEAVRTnpEINDRIRLLEQEVARYKEE 573
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 725 LNKITTQLDQVTAKLQ-------DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEvKASKEQALQDLQQ 797
Cdd:pfam10174 574 SGKAQAEVERLLGILReveneknDKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLE-EARRREDNLADNS 652
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 798 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQD 857
Cdd:pfam10174 653 QQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNLRAERRKQLEEILEMKQE 712
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
428-703 |
1.55e-04 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 46.44 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 428 TKYQHLKAEFKQLQQQREEKeqhgLQLQSEINQLHSKLLETERQLGEAHGRLKE-QRQLssEKLmdKEQQVADLQLKLSR 506
Cdd:PRK11281 49 NKQKLLEAEDKLVQQDLEQT----LALLDKIDRQKEETEQLKQQLAQAPAKLRQaQAEL--EAL--KDDNDEETRETLST 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 507 LeeqlkekvtNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK 586
Cdd:PRK11281 121 L---------SLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPERAQAALYANSQRLQQIRNLLKGGKVGGKALRP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 587 EREDLYakiqagEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQseshkqaqenlHDQVQEQKAHLraaQDRVLSLETSVN 666
Cdd:PRK11281 192 SQRVLL------QAEQALLNAQNDLQRKSLEGNTQLQDLLQKQ-----------RDYLTARIQRL---EHQLQLLQEAIN 251
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 767975501 667 ELNsqLNESKEKVSQLDIQ---IKAKTELLLSAEAAKTAQ 703
Cdd:PRK11281 252 SKR--LTLSEKTVQEAQSQdeaARIQANPLVAQELEINLQ 289
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
935-1160 |
1.75e-04 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 46.44 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 935 TCKELKHQLqvqmeNTLKEQKelkkSLEKEKEASHQlklELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSseqkK 1014
Cdd:PRK11281 37 TEADVQAQL-----DALNKQK----LLEAEDKLVQQ---DLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQA----Q 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1015 KQIEALQGELKIAVLQK------TELE---NKLQQQLTQAAQELAAEKEKISVLQ-----------NNYEKSQETFKQLQ 1074
Cdd:PRK11281 101 AELEALKDDNDEETRETlstlslRQLEsrlAQTLDQLQNAQNDLAEYNSQLVSLQtqperaqaalyANSQRLQQIRNLLK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1075 SDFYGRESeLLATRQDLKSVEEKLSLAQEDLisNRNQIGNQNKLiQELKTAKATLeqdSAKKEQQLQERCKALQDIQKEK 1154
Cdd:PRK11281 181 GGKVGGKA-LRPSQRVLLQAEQALLNAQNDL--QRKSLEGNTQL-QDLLQKQRDY---LTARIQRLEHQLQLLQEAINSK 253
|
....*.
gi 767975501 1155 SLKEKE 1160
Cdd:PRK11281 254 RLTLSE 259
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
934-1154 |
1.78e-04 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 46.16 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 934 KTCKELKHQLQVQMENTLKEQKELKKsLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNE-----KEEQQLQGNINELKQ 1008
Cdd:PHA02562 184 QTLDMKIDHIQQQIKTYNKNIEEQRK-KNGENIARKQNKYDELVEEAKTIKAEIEELTDEllnlvMDIEDPSAALNKLNT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1009 SSEQKKKQIEALQGELKIavLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSdfygRESELLATR 1088
Cdd:PHA02562 263 AAAKIKSKIEQFQKVIKM--YEKGGVCPTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEE----IMDEFNEQS 336
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 1089 QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1154
Cdd:PHA02562 337 KKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEK 402
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
375-761 |
2.26e-04 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 45.82 E-value: 2.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 375 KNIQA--TLHQKDLdCQQLQSRLSAsetslhrihveLSEKGEATQKLKeelsevetKYQHLKAEF----KQLQQQREEKE 448
Cdd:PRK10929 33 EQAKAakTPAQAEI-VEALQSALNW-----------LEERKGSLERAK--------QYQQVIDNFpklsAELRQQLNNER 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 449 QHGL---------QLQSEINQLHSKLLETERQLGEAHGRLKEqrqlSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNST 519
Cdd:PRK10929 93 DEPRsvppnmstdALEQEILQVSSQLLEKSRQAQQEQDRARE----ISDSLSQLPQQQTEARRQLNEIERRLQTLGTPNT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 520 EL-QHQLDKTKqqhqEQQALQQSTTAKLREAQ---NDLEQVLRQIGDKDQK-IQNLEALLQKSKENISLLEK-------E 587
Cdd:PRK10929 169 PLaQAQLTALQ----AESAALKALVDELELAQlsaNNRQELARLRSELAKKrSQQLDAYLQALRNQLNSQRQreaeralE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 588 REDLYAKiQAGEGETAVLNQLQeKNHTLQEQVTQLTEKLKNQSESHKQAQENLHdQVQEQKAHLRaAQDRVLSLETSVNE 667
Cdd:PRK10929 245 STELLAE-QSGDLPKSIVAQFK-INRELSQALNQQAQRMDLIASQQRQAASQTL-QVRQALNTLR-EQSQWLGVSNALGE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 668 -LNSQLNESKE--KVSQLD---IQIKAKT---ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE-----LNKITTQLD 733
Cdd:PRK10929 321 aLRAQVARLPEmpKPQQLDtemAQLRVQRlryEDLLNKQPQLRQIRQADGQPLTAEQNRILDAQLRtqrelLNSLLSGGD 400
|
410 420 430
....*....|....*....|....*....|.
gi 767975501 734 QVTAKLQDKQEHCSQLESHLKEYKE---KYL 761
Cdd:PRK10929 401 TLILELTKLKVANSQLEDALKEVNEathRYL 431
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
587-794 |
2.29e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 46.06 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 587 EREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLtEKLKNQSESHKQAQENLhDQVQEQKAHLRA--AQDRVLSLETS 664
Cdd:COG4913 219 EEPDTFEAADALVEHFDDLERAHEALEDAREQIELL-EPIRELAERYAAARERL-AELEYLRAALRLwfAQRRLELLEAE 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 665 VNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA----KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ 740
Cdd:COG4913 297 LEELRAELARLEAELERLEARLDALREELDELEAQirgnGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLP 376
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 767975501 741 DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 794
Cdd:COG4913 377 ASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIAS 430
|
|
| PRK05771 |
PRK05771 |
V-type ATP synthase subunit I; Validated |
731-991 |
2.52e-04 |
|
V-type ATP synthase subunit I; Validated
Pssm-ID: 235600 [Multi-domain] Cd Length: 646 Bit Score: 45.69 E-value: 2.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 731 QLDQVTAKLQDKQ----EHCSQLESHlkEYKEKYLSLEQKTEELegqIKKLEADSlevkaSKEQALQDLQQQRQLNTDLE 806
Cdd:PRK05771 17 YKDEVLEALHELGvvhiEDLKEELSN--ERLRKLRSLLTKLSEA---LDKLRSYL-----PKLNPLREEKKKVSVKSLEE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 807 LRATELSKQLEMEKEIVSstrldLQKKSEALESIKQKLTKQEEEKKILK---------QDFETLSQET-KIQHEELNNRI 876
Cdd:PRK05771 87 LIKDVEEELEKIEKEIKE-----LEEEISELENEIKELEQEIERLEPWGnfdldlsllLGFKYVSVFVgTVPEDKLEELK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 877 QTTVTELQKVKMEKEALMTELS-TVKDKLSKVSDSLKnsKSEFEKENqkgkaaiLDLEKTCKELKHQLQVQMENTLKEQK 955
Cdd:PRK05771 162 LESDVENVEYISTDKGYVYVVVvVLKELSDEVEEELK--KLGFERLE-------LEEEGTPSELIREIKEELEEIEKERE 232
|
250 260 270
....*....|....*....|....*....|....*.
gi 767975501 956 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQ 991
Cdd:PRK05771 233 SLLEELKELAKKYLEELLALYEYLEIELERAEALSK 268
|
|
| FPP |
pfam05911 |
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant ... |
608-988 |
2.74e-04 |
|
Filament-like plant protein, long coiled-coil; FPP is a family of long coiled-coil plant proteins that are filament-like. It interacts with the nuclear envelope-associated protein, MAF1, the WPP family pfam13943.
Pssm-ID: 461778 [Multi-domain] Cd Length: 859 Bit Score: 45.44 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 608 LQEKNHTLQEQVTQLTEKlkNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIK 687
Cdd:pfam05911 485 LQDINDSLPEADSCLSSG--HPSTDASCDYITCKENSSVVEKEGSVSGDDKSSEETSKQSIQQDLSKAISKIIDFVEGLS 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 688 AKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQqELNKITTQLDQVTAKLQdkqEHCSQL--------ESHLKEYKEK 759
Cdd:pfam05911 563 KEALDDQDTSSDSSELSEVLQQFSATCNDVLSGKA-DLEDFVLELSHILDWIS---NHCFSLldvssmedEIKKHDCIDK 638
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 760 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRqlNTDLELRATELSKQLEMEKEIVSstrLDLQKKSEALES 839
Cdd:pfam05911 639 VTLSENKVAQVDNGCSEIDNLSSDPEIPSDGPLVSGSNDL--KTEENKRLKEEFEQLKSEKENLE---VELASCTENLES 713
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 840 IKQKLTKQEEEKKILKQDFETLsqetkiqhEELNNRIQTtvtELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 919
Cdd:pfam05911 714 TKSQLQESEQLIAELRSELASL--------KESNSLAET---QLKCMAESYEDLETRLTELEAELNELRQKFEALEVELE 782
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 920 KENQKGKaailDLEKTCKELKHQLQVqmentlKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNT 988
Cdd:pfam05911 783 EEKNCHE----ELEAKCLELQEQLER------NEKKESSNCDADQEDKKLQQEKEITAASEKLAECQET 841
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
555-738 |
2.75e-04 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 44.72 E-value: 2.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 555 QVLRQIGDKDqkiqnLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 634
Cdd:pfam00529 46 DVLFQLDPTD-----YQAALDSAEAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 635 QAQENLHDQVQEQKAHLRAAQdrvlSLETSVNELNSQLNESKEKVSQLDIQIKAKTelllsaeAAKTAQRADLQNHLDTA 714
Cdd:pfam00529 121 QAQIDLARRRVLAPIGGISRE----SLVTAGALVAQAQANLLATVAQLDQIYVQIT-------QSAAENQAEVRSELSGA 189
|
170 180
....*....|....*....|....
gi 767975501 715 QNALQDKQQELNKITTQLDQVTAK 738
Cdd:pfam00529 190 QLQIAEAEAELKLAKLDLERTEIR 213
|
|
| ClpA |
COG0542 |
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ... |
412-515 |
2.76e-04 |
|
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 45.46 E-value: 2.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 412 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQ-REEKE--QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE 488
Cdd:COG0542 431 KKEQDEASFERLAELRDELAELEEELEALKARwEAEKEliEEIQELKEELEQRYGKIPELEKELAELEEELAELAPLLRE 510
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 767975501 489 --------------------KLMDKEQQvadlqlKLSRLEEQLKEKV 515
Cdd:COG0542 511 evteediaevvsrwtgipvgKLLEGERE------KLLNLEEELHERV 551
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
544-780 |
2.80e-04 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 45.71 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 544 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK--------EREDLYAKIQAGEGEtavLNQLQEKNHTL 615
Cdd:COG3096 836 AELAALRQRRSELERELAQHRAQEQQLRQQLDQLKEQLQLLNKllpqanllADETLADRLEELREE---LDAAQEAQAFI 912
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 616 QEQVTQLT--EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN--------ELNSQLNESKEKVSQLDIQ 685
Cdd:COG3096 913 QQHGKALAqlEPLVAVLQSDPEQFEQLQADYLQAKEQQRRLKQQIFALSEVVQrrphfsyeDAVGLLGENSDLNEKLRAR 992
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 686 I-KAKTELLLSAEAAKTAQ---------RADLQNHLDTAQNALQDKQQELNKITTQLDQVTA-----KLQDKQEHCSQLE 750
Cdd:COG3096 993 LeQAEEARREAREQLRQAQaqysqynqvLASLKSSRDAKQQTLQELEQELEELGVQADAEAEerariRRDELHEELSQNR 1072
|
250 260 270
....*....|....*....|....*....|
gi 767975501 751 SHLKEYKEKYLSLEQKTEELEGQIKKLEAD 780
Cdd:COG3096 1073 SRRSQLEKQLTRCEAEMDSLQKRLRKAERD 1102
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
626-744 |
3.01e-04 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 44.72 E-value: 3.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 626 LKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLdiqikaktelllSAEAAKTAQra 705
Cdd:TIGR04320 252 PPNSLAALQAKLATAQADLAAAQTALNTAQAALTSAQTAYAAAQAALATAQKELANA------------QAQALQTAQ-- 317
|
90 100 110
....*....|....*....|....*....|....*....
gi 767975501 706 dlqNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 744
Cdd:TIGR04320 318 ---NNLATAQAALANAEARLAKAKEALANLNADLAKKQA 353
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
205-446 |
3.14e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 45.39 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 205 QKAAQLATEIADIKSKYDEERSlREAAEQKVTRLTEELNKEATVIQDLKTEL---LQRPGIEDVAVLKKELVQVQTlmdn 281
Cdd:COG3206 148 ELAAAVANALAEAYLEQNLELR-REEARKALEFLEEQLPELRKELEEAEAALeefRQKNGLVDLSEEAKLLLQQLS---- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 282 mTLEREREseklkdeckKLQSQYASSEATISQLRSELAKGPQEVAVYVQ--ELQKLKSSVNELTQKNQTLTENLLKKEQD 359
Cdd:COG3206 223 -ELESQLA---------EARAELAEAEARLAALRAQLGSGPDALPELLQspVIQQLRAQLAELEAELAELSARYTPNHPD 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 360 YTKLEEKHNE-ESVSKKNIQATLHQKDLDCQQLQSRLSASETSLhrihVELSEKGEATQKLKEELSEVETKYQHLKAEFK 438
Cdd:COG3206 293 VIALRAQIAAlRAQLQQEAQRILASLEAELEALQAREASLQAQL----AQLEARLAELPELEAELRRLEREVEVARELYE 368
|
....*...
gi 767975501 439 QLQQQREE 446
Cdd:COG3206 369 SLLQRLEE 376
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
87-658 |
3.16e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 45.29 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 87 QCMKSLGSADELFKHY-----EAVHDAGNDSGH-----GGESNLALKRDDVTLLRQEVQDLQ--ASLKEEKWYSEELKKE 154
Cdd:COG4913 201 QSFKPIGDLDDFVREYmleepDTFEAADALVEHfddleRAHEALEDAREQIELLEPIRELAEryAAARERLAELEYLRAA 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 155 LEKYQGLQQQEAKpDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ--------LATEIADIKSKYDEERS 226
Cdd:COG4913 281 LRLWFAQRRLELL-EAELEELRAELARLEAELERLEARLDALREELDELEAQIRGnggdrleqLEREIERLERELEERER 359
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 227 LREAAEQKVTRLTEELNKEATVIQDLKTELLQRpgiedVAVLKKELVQVQTLMDnmtlERERESEKLKDECKKLQSQYAS 306
Cdd:COG4913 360 RRARLEALLAALGLPLPASAEEFAALRAEAAAL-----LEALEEELEALEEALA----EAEAALRDLRRELRELEAEIAS 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 307 SEATIS-------QLRSELAK--GPQEVAV-YVQELQKLKSSVN------ELTQKNQTLTenLLKKEQDY---------T 361
Cdd:COG4913 431 LERRKSniparllALRDALAEalGLDEAELpFVGELIEVRPEEErwrgaiERVLGGFALT--LLVPPEHYaaalrwvnrL 508
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 362 KLEEKHNEESVSKKniqatlhqkdldcQQLQSRLSASETSLhrIHVELSEKGEATQKLKEELSE------VET-----KY 430
Cdd:COG4913 509 HLRGRLVYERVRTG-------------LPDPERPRLDPDSL--AGKLDFKPHPFRAWLEAELGRrfdyvcVDSpeelrRH 573
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 431 Q---------HLKAEFKQLQQQREEKEQH--GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQlsseklmdKEQQVAD 499
Cdd:COG4913 574 PraitragqvKGNGTRHEKDDRRRIRSRYvlGFDNRAKLAALEAELAELEEELAEAEERLEALEA--------ELDALQE 645
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 500 LQLKLSRLEEQLKEKVtNSTELQHQLDKTKQQHqeqqalqqsttAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 579
Cdd:COG4913 646 RREALQRLAEYSWDEI-DVASAEREIAELEAEL-----------ERLDASSDDLAALEEQLEELEAELEELEEELDELKG 713
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 580 NISLLEKEREDLYAKIQAGEGETAVLNQLQEknhtlQEQVTQLTEKLKN--QSESHKQAQENLHDQVQEQKAHLRAAQDR 657
Cdd:COG4913 714 EIGRLEKELEQAEEELDELQDRLEAAEDLAR-----LELRALLEERFAAalGDAVERELRENLEERIDALRARLNRAEEE 788
|
.
gi 767975501 658 V 658
Cdd:COG4913 789 L 789
|
|
| FYVE_CARP1 |
cd15769 |
FYVE-like domain found in caspase regulator CARP1 and similar proteins; CARP1, also termed E3 ... |
1400-1447 |
3.73e-04 |
|
FYVE-like domain found in caspase regulator CARP1 and similar proteins; CARP1, also termed E3 ubiquitin-protein ligase RNF34, or caspases-8 and -10-associated RING finger protein 1, or FYVE-RING finger protein Momo, or RING finger homologous to inhibitor of apoptosis protein (RFI), or RING finger protein 34, or RING finger protein RIFF, is a nuclear protein that functions as a specific E3 ubiquitin ligase for the transcriptional coactivator PGC-1alpha, a master regulator of energy metabolism and adaptive thermogenesis in the brown fat cell, and negatively regulates brown fat cell metabolism. It is preferentially expressed in esophageal, gastric and colorectal cancers, suggesting a possible association with the development of the digestive tract cancers. It regulates the p53 signaling pathway through degrading 14-3-3 sigma and stabilizing MDM2. CARP1 does not localize to membranes in the cell and is involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8 and caspase 10, which are distinguished from other FYVE-type proteins. Moreover, CARP1 has an altered sequence in the basic ligand binding patch and lack the WxxD (x for any residue) motif that is conserved only in phosphoinositide binding FYVE domains. Thus it belongs to a family of unique FYVE-type domains called FYVE-like domains. In addition to the N-terminal FYVE-like domain, CARP1 harbors a C-terminal RING domain.
Pssm-ID: 277308 Cd Length: 47 Bit Score: 39.59 E-value: 3.73e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 767975501 1400 CMACGKGFSVTVRRHHCRQCGNIFCAECSAknaltpsSKKPVRVCDAC 1447
Cdd:cd15769 4 CKACGLAFSVFRKKHVCCDCKKDFCSVCSV-------LQENLRRCSTC 44
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
174-365 |
4.25e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 44.37 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 174 DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLK 253
Cdd:COG4942 24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 254 TEL------LQRPGIEDVAVLK------KELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKG 321
Cdd:COG4942 104 EELaellraLYRLGRQPPLALLlspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAEL 183
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 767975501 322 PQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 365
Cdd:COG4942 184 EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEA 227
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
882-1111 |
5.46e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 43.98 E-value: 5.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 882 ELQKVKMEKEALMTELSTVKDKLSKvsdsLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV---QMENTLKEQKELK 958
Cdd:COG4942 21 AAAEAEAELEQLQQEIAELEKELAA----LKKEEKALLKQLAALERRIAALARRIRALEQELAAleaELAELEKEIAELR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 959 KSLEKEKEashQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKL 1038
Cdd:COG4942 97 AELEAQKE---ELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAER 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1039 QQQLTQaaqeLAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1111
Cdd:COG4942 174 AELEAL----LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
1116-1339 |
6.57e-04 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 44.26 E-value: 6.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1116 NKLIQELKTAKATLEQDSAKKEQQlQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK-- 1193
Cdd:PRK02224 209 NGLESELAELDEEIERYEEQREQA-RETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRer 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1194 -LESIKEITNLKDAKQL-------LIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK------KEEEELKKEFIEKEAK 1259
Cdd:PRK02224 288 lEELEEERDDLLAEAGLddadaeaVEARREELEDRDEELRDRLEECRVAAQAHNEEAEslredaDDLEERAEELREEAAE 367
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1260 LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD---ERRA 1336
Cdd:PRK02224 368 LESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARErveEAEA 447
|
...
gi 767975501 1337 LLE 1339
Cdd:PRK02224 448 LLE 450
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
129-688 |
6.58e-04 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 44.51 E-value: 6.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 129 LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQ-MKDL--FEQ 205
Cdd:PRK01156 170 KLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSaLNELssLED 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 206 KAAQLATEIADIKSKydeeRSLREAAEQKVTRLTEELNKeatVIQDlkTELLQRPGIEDVAVLKKELVQVQTLMDNMTLE 285
Cdd:PRK01156 250 MKNRYESEIKTAESD----LSMELEKNNYYKELEERHMK---IIND--PVYKNRNYINDYFKYKNDIENKKQILSNIDAE 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 286 RERESEKLKdECKKLQSQYasSEATISQLRSElakgpqevavyvqELQKLKSSVNELTQKNQTLTENLlkkEQDYTKLEE 365
Cdd:PRK01156 321 INKYHAIIK-KLSVLQKDY--NDYIKKKSRYD-------------DLNNQILELEGYEMDYNSYLKSI---ESLKKKIEE 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 366 KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQL---QQ 442
Cdd:PRK01156 382 YSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQSVCPvcgTT 461
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 443 QREEKEQHGLQLQSE-INQLHSKLLETERQLGEAHGRLKEQRQLSS--------------EKLMDKEQQVADLQLKLSRL 507
Cdd:PRK01156 462 LGEEKSNHIINHYNEkKSRLEEKIREIEIEVKDIDEKIVDLKKRKEyleseeinksineyNKIESARADLEDIKIKINEL 541
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 508 E------EQLKEKVtNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ-NLEALLQKSKEN 580
Cdd:PRK01156 542 KdkhdkyEEIKNRY-KSLKLEDLDSKRTSWLNALAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEiGFPDDKSYIDKS 620
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 581 ISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQE------NLHDQVQEQKAHLRAA 654
Cdd:PRK01156 621 IREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDiednlkKSRKALDDAKANRARL 700
|
570 580 590
....*....|....*....|....*....|....
gi 767975501 655 QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 688
Cdd:PRK01156 701 ESTIEILRTRINELSDRINDINETLESMKKIKKA 734
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
584-1375 |
6.67e-04 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 44.27 E-value: 6.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 584 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD------QVQEQKAHLRAAQDR 657
Cdd:TIGR00606 191 LRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPlknrlkEIEHNLSKIMKLDNE 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 658 VLSLETSVNE---LNSQLNESKEKVSQ-LDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD 733
Cdd:TIGR00606 271 IKALKSRKKQmekDNSELELKMEKVFQgTDEQLNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQG 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 734 QVTAKLQDKQEHC---------SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTD 804
Cdd:TIGR00606 351 RLQLQADRHQEHIrardsliqsLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADE 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 805 LELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK----------QKLTKQEEEKKILKQDFET---LSQETKIQHEE 871
Cdd:TIGR00606 431 IRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEgssdrileldQELRKAERELSKAEKNSLTetlKKEVKSLQNEK 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 872 LN--NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEfeKENQKGKAAILDLEKTCKELKHQLQVQMEN 949
Cdd:TIGR00606 511 ADldRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRH--SDELTSLLGYFPNKKQLEDWLHSKSKEINQ 588
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 950 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQnEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 1029
Cdd:TIGR00606 589 TRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFD-VCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQ 667
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1030 QKTELENKLQQQLTQAAQELAAEKEK---ISVLQNNYEKSQETFKQLQSDFY--------------GRESELLATRQDLK 1092
Cdd:TIGR00606 668 FITQLTDENQSCCPVCQRVFQTEAELqefISDLQSKLRLAPDKLKSTESELKkkekrrdemlglapGRQSIIDLKEKEIP 747
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1093 SVEEKLSLAQEDLISNRNQIGNQNKLIQ----ELKTAKA-------------TLEQDSAKKEQQLQER-----CKALQDI 1150
Cdd:TIGR00606 748 ELRNKLQKVNRDIQRLKNDIEEQETLLGtimpEEESAKVcltdvtimerfqmELKDVERKIAQQAAKLqgsdlDRTVQQV 827
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1151 QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE---ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAA 1227
Cdd:TIGR00606 828 NQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSktnELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDA 907
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1228 VEQEKRNQQILKDqvkkeeeelkkefiekeaklhsEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVS 1307
Cdd:TIGR00606 908 KEQDSPLETFLEK----------------------DQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQ 965
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1308 E-LEKQTDDLRGEIAVLEATVQNNQDERRALLE--RCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1375
Cdd:TIGR00606 966 DgKDDYLKQKETELNTVNAQLEECEKHQEKINEdmRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEE 1036
|
|
| FYVE_CARP2 |
cd15770 |
FYVE-like domain found in caspase regulator CARP2 and similar proteins; CARP2, also termed E3 ... |
1398-1436 |
6.70e-04 |
|
FYVE-like domain found in caspase regulator CARP2 and similar proteins; CARP2, also termed E3 ubiquitin-protein ligase rififylin, or caspases-8 and -10-associated RING finger protein 2, or FYVE-RING finger protein Sakura (Fring), or RING finger and FYVE-like domain-containing protein 1, or RING finger protein 189, or RING finger protein 34-like, is a novel caspase regulator containing a FYVE-type zinc finger domain. It regulates the p53 signaling pathway through degrading 14-3-3 sigma and stabilizing MDM2. CARP2 does not localize to membranes in the cell and is involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8 and caspase 10, which are distinguished from other FYVE-type proteins. Moreover, CARP2 has an altered sequence in the basic ligand binding patch and lack the WxxD (x for any residue) motif that is conserved only in phosphoinositide binding FYVE domains. Thus it belongs to a family of unique FYVE-type domains called FYVE-like domains. In addition to the N-terminal FYVE-like domain, CARP2 harbors a C-terminal RING domain.
Pssm-ID: 277309 Cd Length: 49 Bit Score: 39.06 E-value: 6.70e-04
10 20 30
....*....|....*....|....*....|....*....
gi 767975501 1398 QNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPS 1436
Cdd:cd15770 2 ISCKACGIRFASCARKHPCMDCKKNYCTACSSQAENGPS 40
|
|
| PRK09039 |
PRK09039 |
peptidoglycan -binding protein; |
579-744 |
7.10e-04 |
|
peptidoglycan -binding protein;
Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 43.42 E-value: 7.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 579 ENISLLEKEREDLYAKIqagegetAVLNQL----QEKNHTLQEQVTQLTEKLkNQSESHKQAQENLHDQVQEQKAhlraa 654
Cdd:PRK09039 46 REISGKDSALDRLNSQI-------AELADLlsleRQGNQDLQDSVANLRASL-SAAEAERSRLQALLAELAGAGA----- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 655 qdrvlSLETSVNELNSQLNESKekvsQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDq 734
Cdd:PRK09039 113 -----AAEGRAGELAQELDSEK----QVSARALAQVELLNQQIAALRRQLAALEAALDASEKRDRESQAKIADLGRRLN- 182
|
170
....*....|
gi 767975501 735 vTAKLQDKQE 744
Cdd:PRK09039 183 -VALAQRVQE 191
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
924-1036 |
7.47e-04 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 44.00 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 924 KGKAAILDLEKTCKELKHQLQVQMENTLKEQ--------KELKKSLEKEkeaSHQLKLELNSMQEQLIQAQNTLKQNEKE 995
Cdd:PRK12704 28 IAEAKIKEAEEEAKRILEEAKKEAEAIKKEAlleakeeiHKLRNEFEKE---LRERRNELQKLEKRLLQKEENLDRKLEL 104
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 767975501 996 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVL-QKTELEN 1036
Cdd:PRK12704 105 LEKREEELEKKEKELEQKQQELEKKEEELEELIEeQLQELER 146
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
177-581 |
8.25e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 43.99 E-value: 8.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 177 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAE-----QKVTRLTEELNKEATVIQD 251
Cdd:COG4717 71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQllplyQELEALEAELAELPERLEE 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 252 LKTELLQ-RPGIEDVAVLKKELVQVQT----LMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA 326
Cdd:COG4717 151 LEERLEElRELEEELEELEAELAELQEeleeLLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELE 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 327 VYVQELQKLKsSVNELTQKNQTL-----------------------------------------TENLLKKEQDYTKLEE 365
Cdd:COG4717 231 QLENELEAAA-LEERLKEARLLLliaaallallglggsllsliltiagvlflvlgllallflllAREKASLGKEAEELQA 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 366 KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEvetkyQHLKAEFKQLQQQRE 445
Cdd:COG4717 310 LPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELE-----QEIAALLAEAGVEDE 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 446 EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMdkEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 525
Cdd:COG4717 385 EELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEEL--EEELEELEEELEELEEELEELREELAELEAEL 462
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 767975501 526 DKTKQQHqeqqalqqsTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 581
Cdd:COG4717 463 EQLEEDG---------ELAELLQELEELKAELRELAEEWAALKLALELLEEAREEY 509
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
178-681 |
8.31e-04 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 43.95 E-value: 8.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 178 ELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELL 257
Cdd:pfam15921 343 KIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELD 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 258 QRpgiedvavlkkelvqvqtlmdNMTLER-ERESEKLKDECkklQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLK 336
Cdd:pfam15921 423 DR---------------------NMEVQRlEALLKAMKSEC---QGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLR 478
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 337 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ------SRLSASETSLHRIHVELS 410
Cdd:pfam15921 479 KVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQhlknegDHLRNVQTECEALKLQMA 558
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 411 EKGEATQKLKEELSEV-ETKYQH------LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR 483
Cdd:pfam15921 559 EKDKVIEILRQQIENMtQLVGQHgrtagaMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLV 638
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 484 QLSSEKLmdkeQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK----LREAQNDLEQVLRQ 559
Cdd:pfam15921 639 NAGSERL----RAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKlkmqLKSAQSELEQTRNT 714
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 560 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAgeGETAVLNQLQEKnHTLQEQVTQLTEKLKN-QSESHKQAQE 638
Cdd:pfam15921 715 LKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQF--LEEAMTNANKEK-HFLKEEKNKLSQELSTvATEKNKMAGE 791
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 767975501 639 nlhdqVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ 681
Cdd:pfam15921 792 -----LEVLRSQERRLKEKVANMEVALDKASLQFAECQDIIQR 829
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
103-439 |
8.47e-04 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 43.88 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 103 EAVHDAGNDSGhGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQ----GLQQQEAKPDGLVTDSSAE 178
Cdd:PRK02224 398 ERFGDAPVDLG-NAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRER 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 179 LQSLEQQLEEAQTENFNIKQMKDLFEQkAAQLATEIADIKSKYDEERSL----REAAEQKVTRLtEELNKEAtviQDLKT 254
Cdd:PRK02224 477 VEELEAELEDLEEEVEEVEERLERAED-LVEAEDRIERLEERREDLEELiaerRETIEEKRERA-EELRERA---AELEA 551
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 255 EllqrpgiedvAVLKKELVQvqtlmdnmtlERERESEKLKDECKKLQSQYASSEATISQLRsELAKGPQEVAVYVQELQK 334
Cdd:PRK02224 552 E----------AEEKREAAA----------EAEEEAEEAREEVAELNSKLAELKERIESLE-RIRTLLAAIADAEDEIER 610
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 335 LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK------------KNIQATLHQKDLDCQQLQSRLSASETSL 402
Cdd:PRK02224 611 LREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEaredkeraeeylEQVEEKLDELREERDDLQAEIGAVENEL 690
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 767975501 403 HRI------HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQ 439
Cdd:PRK02224 691 EELeelrerREALENRVEALEALYDEAEELESMYGDLRAELRQ 733
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
452-1158 |
8.69e-04 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 44.06 E-value: 8.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 452 LQLQSEINQLHSKLLEterqLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTnstELQHQLDKTKQQ 531
Cdd:pfam12128 244 TKLQQEFNTLESAELR----LSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRD---ELNGELSAADAA 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 532 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSkenISLLEKEREDLYAKIQAGEGETAV-LNQLQE 610
Cdd:pfam12128 317 VAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEER---LKALTGKHQDVTAKYNRRRSKIKEqNNRDIA 393
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 611 KNHTLQEQVTQLTEKLKNQSESHKQAQEN-LHDQVQEQKAHLRAAQDRvlsLETSVNELNSQLNeSKEKVSQLDIQIKAK 689
Cdd:pfam12128 394 GIKDKLAKIREARDRQLAVAEDDLQALESeLREQLEAGKLEFNEEEYR---LKSRLGELKLRLN-QATATPELLLQLENF 469
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 690 TELLLSAEAAKTAQRADLQnhldtaqnalqDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKylsLEQKTEE 769
Cdd:pfam12128 470 DERIERAREEQEAANAEVE-----------RLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQ---LFPQAGT 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 770 LegqikkLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEkeiVSSTRLDLQKkSEALESIKQkltkqEE 849
Cdd:pfam12128 536 L------LHFLRKEAPDWEQSIGKVISPELLHRTDLDPEVWDGSVGGELN---LYGVKLDLKR-IDVPEWAAS-----EE 600
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 850 EKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDslknsksefEKENQKGKaai 929
Cdd:pfam12128 601 ELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFD---------EKQSEKDK--- 668
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 930 ldLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNekeeqQLQGNINELKQS 1009
Cdd:pfam12128 669 --KNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDA-----QLALLKAAIAAR 741
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1010 SEQKKKQIEALQGELKIAvLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEK----SQETFKQ----LQSDFYGRE 1081
Cdd:pfam12128 742 RSGAKAELKALETWYKRD-LASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRyfdwYQETWLQrrprLATQLSNIE 820
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1082 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQEL---------KTAKATLEQDSAKKEQQLQERCKALQDIQ- 1151
Cdd:pfam12128 821 RAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENlrglrcemsKLATLKEDANSEQAQGSIGERLAQLEDLKl 900
|
....*..
gi 767975501 1152 KEKSLKE 1158
Cdd:pfam12128 901 KRDYLSE 907
|
|
| PTZ00440 |
PTZ00440 |
reticulocyte binding protein 2-like protein; Provisional |
127-1021 |
9.07e-04 |
|
reticulocyte binding protein 2-like protein; Provisional
Pssm-ID: 240419 [Multi-domain] Cd Length: 2722 Bit Score: 44.05 E-value: 9.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 127 VTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQk 206
Cdd:PTZ00440 452 INELKKSINQLKTLISIMKSFYDLIISEKDSMDSKEKKESSDSNYQEKVDELLQIINSIKEKNNIVNNNFKNIEDYYIT- 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 207 aaqlateIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPG----IEDVAVLKKELVQVQTLMDNM 282
Cdd:PTZ00440 531 -------IEGLKNEIEGLIELIKYYLQSIETLIKDEKLKRSMKNDIKNKIKYIEEnvdhIKDIISLNDEIDNIIQQIEEL 603
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 283 TLERERESEKLKDECKKLQsqyasseATISQLRSELAKGPQEVAVYVQE--LQKLKSSVNELTQKNQtLTENLLKKEQDY 360
Cdd:PTZ00440 604 INEALFNKEKFINEKNDLQ-------EKVKYILNKFYKGDLQELLDELShfLDDHKYLYHEAKSKED-LQTLLNTSKNEY 675
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 361 TKLEEKHNEesvskkNIQATLHQKDldcQQLQSRLSASETSLHRIHVELSekgeatQKLKEELSEVETKYQHLKAEFKQL 440
Cdd:PTZ00440 676 EKLEFMKSD------NIDNIIKNLK---KELQNLLSLKENIIKKQLNNIE------QDISNSLNQYTIKYNDLKSSIEEY 740
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 441 QQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHgRLKEQRQLSSEKLMDKEQQVADlQLKLSRLEEQLKEKVTNSTE 520
Cdd:PTZ00440 741 KEEEEKLEVYKHQIINRKNEFILHLYENDKDLPDGK-NTYEEFLQYKDTILNKENKISN-DINILKENKKNNQDLLNSYN 818
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 521 LQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKeredLYAKIQAGEG 600
Cdd:PTZ00440 819 ILIQKLEAHTEKNDEELKQLLQKFPTEDENLNLKELEKEFNENNQIVDNIIKDIENMNKNINIIKT----LNIAINRSNS 894
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 601 ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDrvlslETSVNELNSQLNESKEKVS 680
Cdd:PTZ00440 895 NKQLVEHLLNNKIDLKNKLEQHMKIINTDNIIQKNEKLNLLNNLNKEKEKIEKQLS-----DTKINNLKMQIEKTLEYYD 969
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 681 QLDIQIKAKTELLLSAEAAKTAQRADLQ---NHLDTAQNALQDK------QQELNKITTQLDQVTAKLQDKQEHCSQLES 751
Cdd:PTZ00440 970 KSKENINGNDGTHLEKLDKEKDEWEHFKseiDKLNVNYNILNKKiddlikKQHDDIIELIDKLIKEKGKEIEEKVDQYIS 1049
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 752 HLKEYKEKYLSLE-------QKTEELEGQIKKLEAdslEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 824
Cdd:PTZ00440 1050 LLEKMKTKLSSFHfnidikkYKNPKIKEEIKLLEE---KVEALLKKIDENKNKLIEIKNKSHEHVVNADKEKNKQTEHYN 1126
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 825 STRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 904
Cdd:PTZ00440 1127 KKKKSLEKIYKQMEKTLKELENMNLEDITLNEVNEIEIEYERILIDHIVEQINNEAKKSKTIMEEIESYKKDIDQVKKNM 1206
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 905 SK-------------VSDSLKNSKSEFEK-----ENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKE 966
Cdd:PTZ00440 1207 SKerndhlttfeynaYYDKATASYENIEEltteaKGLKGEANRSTNVDELKEIKLQVFSYLQQVIKENNKMENALHEIKN 1286
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767975501 967 ASHQLKLE---------LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQ 1021
Cdd:PTZ00440 1287 MYEFLISIdsekilkeiLNSTKKAEEFSNDAKKELEKTDNLIKQVEAKIEQAKEHKNKIYGSLE 1350
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
150-775 |
9.74e-04 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 43.80 E-value: 9.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 150 ELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENfnikqmkdlfeqkaaQLATEIADIKSKYDEERSLRE 229
Cdd:TIGR00618 195 KAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQT---------------QQSHAYLTQKREAQEEQLKKQ 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 230 AAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 309
Cdd:TIGR00618 260 QLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSS 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 310 TISQLRSELAKGPQEVAVYVQELQKLksSVNELTQKNQTLTENLLKKEQDYTKLEEKHN---EESVSKKNIQATLHQKDL 386
Cdd:TIGR00618 340 IEEQRRLLQTLHSQEIHIRDAHEVAT--SIREISCQQHTLTQHIHTLQQQKTTLTQKLQslcKELDILQREQATIDTRTS 417
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 387 DCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQlQSEINQLHSKLL 466
Cdd:TIGR00618 418 AFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQ-ETRKKAVVLARL 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 467 ----ETERQLGEAHGRLKEQRQLSSE------KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 536
Cdd:TIGR00618 497 lelqEEPCPLCGSCIHPNPARQDIDNpgpltrRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILT 576
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 537 ALQQSTTAKLREAQNDLEQVLRQIGdkdqkiQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 616
Cdd:TIGR00618 577 QCDNRSKEDIPNLQNITVRLQDLTE------KLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHA 650
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 617 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 696
Cdd:TIGR00618 651 LQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSL 730
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 697 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK 775
Cdd:TIGR00618 731 GSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIG 809
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
117-630 |
1.19e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 43.51 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 117 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI 196
Cdd:PRK03918 199 EKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 197 -KQMKDLFE-QKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIE-----DVAVLK 269
Cdd:PRK03918 279 eEKVKELKElKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLkelekRLEELE 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 270 ---KELVQVQTLMDNMTLERERES----EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 342
Cdd:PRK03918 359 erhELYEEAKAKKEELERLKKRLTgltpEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKC 438
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 343 TQKNQTLTE----NLLKK--------EQDYTKLEEKHNEESVSKKNIQATLHQ--KDLDCQQLQSRLSASETSLHRIHVE 408
Cdd:PRK03918 439 PVCGRELTEehrkELLEEytaelkriEKELKEIEEKERKLRKELRELEKVLKKesELIKLKELAEQLKELEEKLKKYNLE 518
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 409 -LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEqhglQLQSEINQLHSKLLETERQLG--------EAHGRL 479
Cdd:PRK03918 519 eLEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLA----ELEKKLDELEEELAELLKELEelgfesveELEERL 594
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 480 KEQRQLSSE--KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQqsTTAKLREAQNDLEQVL 557
Cdd:PRK03918 595 KELEPFYNEylELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKY--SEEEYEELREEYLELS 672
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 558 RQIGDKDQKIQNLEALLQKSKENISLLEKEREdlyaKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 630
Cdd:PRK03918 673 RELAGLRAELEELEKRREEIKKTLEKLKEELE----EREKAKKELEKLEKALERVEELREKVKKYKALLKERA 741
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
946-1154 |
1.26e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 42.89 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 946 QMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALqgelk 1025
Cdd:COG3883 17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGER----- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1026 IAVLQKTELENKLQQQ--LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1103
Cdd:COG3883 92 ARALYRSGGSVSYLDVllGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKA 171
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 767975501 1104 DLISNRNQignQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1154
Cdd:COG3883 172 ELEAQQAE---QEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
808-1199 |
1.30e-03 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 43.50 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 808 RATELSKQLEMEKEIVSSTRLDLqkkseaLESIKQKLTKQEEEKKILkqdfetlsqetkiqHEELNNRIQTTVTELQKVK 887
Cdd:PTZ00108 996 RKEYLLGKLERELARLSNKVRFI------KHVINGELVITNAKKKDL--------------VKELKKLGYVRFKDIIKKK 1055
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 888 MEKealmtelSTVKDKLSKVSDSLKNSKS-EFEKENQKGKAAILDLEKT--CKELKHQLQVQMENTLKEQKELKKS---- 960
Cdd:PTZ00108 1056 SEK-------ITAEEEEGAEEDDEADDEDdEEELGAAVSYDYLLSMPIWslTKEKVEKLNAELEKKEKELEKLKNTtpkd 1128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 961 -----LEKEKEA--SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTE 1033
Cdd:PTZ00108 1129 mwledLDKFEEAleEQEEVEEKEIAKEQRLKSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRK 1208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1034 LENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEllATRQDLKSVEEKLSLAQEDLISNRNQIG 1113
Cdd:PTZ00108 1209 LDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDND--EFSSDDLSKEGKPKNAPKRVSAVQYSPP 1286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1114 NQNKLIQELKTAKATLEQDSAKKEQQLqercKALQDIQKEKSLKEKELVNEKSKLAEiEEIKCRQEKEiTKLNEELKSHK 1193
Cdd:PTZ00108 1287 PPSKRPDGESNGGSKPSSPTKKKVKKR----LEGSLAALKKKKKSEKKTARKKKSKT-RVKQASASQS-SRLLRRPRKKK 1360
|
....*.
gi 767975501 1194 LESIKE 1199
Cdd:PTZ00108 1361 SDSSSE 1366
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
505-779 |
1.39e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 43.41 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 505 SRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE---AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 581
Cdd:PRK04863 275 MRHANERRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAElneAESDLEQDYQAASDHLNLVQTALRQQEKIERYQ 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 582 SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKN-------------QSESHKQA------------ 636
Cdd:PRK04863 355 ADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADyqqaldvqqtraiQYQQAVQAlerakqlcglpd 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 637 --QENLHDQVQEQKAHLRAAQDRVLSLETSVN---ELNSQLNESKEKVSQLDIQIKAKT------ELLLSAEAAK--TAQ 703
Cdd:PRK04863 435 ltADNAEDWLEEFQAKEQEATEELLSLEQKLSvaqAAHSQFEQAYQLVRKIAGEVSRSEawdvarELLRRLREQRhlAEQ 514
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 704 RADLQNHLDTAQNALQdKQQELNKITTQLDQVTAK-------LQDKQEHCSQLESHLKEYK----EKYLSLEQKTEELEG 772
Cdd:PRK04863 515 LQQLRMRLSELEQRLR-QQQRAERLLAEFCKRLGKnlddedeLEQLQEELEARLESLSESVsearERRMALRQQLEQLQA 593
|
....*..
gi 767975501 773 QIKKLEA 779
Cdd:PRK04863 594 RIQRLAA 600
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
295-527 |
1.59e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 42.44 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 295 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK 374
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 375 KNIQATLhQKDLDCQQLQSRLSASETSLHRihvelsekgeatqklkEELSEVETKYQHLKaefkQLQQQREEKEQHGLQL 454
Cdd:COG4942 100 EAQKEEL-AELLRALYRLGRQPPLALLLSP----------------EDFLDAVRRLQYLK----YLAPARREQAEELRAD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 455 QSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDK 527
Cdd:COG4942 159 LAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
286-678 |
1.63e-03 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 42.97 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 286 RERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQEL-QKLKSSVNELTQKN-QTLTENLLKKEQDYTKL 363
Cdd:PLN02939 40 RGFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLRTVMELpQKSTSSDDDHNRASmQRDEAIAAIDNEQQTNS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 364 EEKHNEESVSKKNIQATLHQKDLDCQQL-QSRLSAsetsLHRIHVELSEKgeatQKLKEELSEVETKYQHLKAEFKQLQQ 442
Cdd:PLN02939 120 KDGEQLSDFQLEDLVGMIQNAEKNILLLnQARLQA----LEDLEKILTEK----EALQGKINILEMRLSETDARIKLAAQ 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 443 QREEKEQHGLQLQSEINQLhskLLETERQLGEAHGRLKEQRQLSSEKLMDKeqqvADLQLklsrleeqLKEKVTNSTELQ 522
Cdd:PLN02939 192 EKIHVEILEEQLEKLRNEL---LIRGATEGLCVHSLSKELDVLKEENMLLK----DDIQF--------LKAELIEVAETE 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 523 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL-RQIGDKDQKIQNLEALLQKSK---ENISLLEKEREDLYAKIQAG 598
Cdd:PLN02939 257 ERVFKLEKERSLLDASLRELESKFIVAQEDVSKLSpLQYDCWWEKVENLQDLLDRATnqvEKAALVLDQNQDLRDKVDKL 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 599 EGETAVLNQLQEKNhtlqEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDrvlsletsvnELNSQLNESKEK 678
Cdd:PLN02939 337 EASLKEANVSKFSS----YKVELLQQKLKLLEERLQASDHEIHSYIQLYQESIKEFQD----------TLSKLKEESKKR 402
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
421-1148 |
1.92e-03 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 42.85 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 421 EELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL-LETE--RQLGEAHGRLKEQRQLSSEKLMDKEQQV 497
Cdd:pfam01576 5 EEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLqAETElcAEAEEMRARLAARKQELEEILHELESRL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 498 ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKS 577
Cdd:pfam01576 85 EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISEF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 578 KENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 657
Cdd:pfam01576 165 TSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEE 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 658 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTaqradlqnhldTAQNALQDKQQELNKITTQLDQVTA 737
Cdd:pfam01576 245 LQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARN-----------KAEKQRRDLGEELEALKTELEDTLD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 738 KLQDKQEHCSQLESHLKEYKEkylSLEQKTEELEGQIkkleadslevkasKEQALQDLQQQRQLNTDLElRATELSKQLE 817
Cdd:pfam01576 314 TTAAQQELRSKREQEVTELKK---ALEEETRSHEAQL-------------QEMRQKHTQALEELTEQLE-QAKRNKANLE 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 818 MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTEL 897
Cdd:pfam01576 377 KAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKN 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 898 STVKDKLSKVSDSLKNSKSEFEKENQKgKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 977
Cdd:pfam01576 457 IKLSKDVSSLESQLQDTQELLQEETRQ-KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEE 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 978 MQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK---IAVLQKTELENKLQQQLTQAAQELAAEKE 1054
Cdd:pfam01576 536 DAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDdllVDLDHQRQLVSNLEKKQKKFDQMLAEEKA 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1055 KISVLQNNYEKSQETFKQLQSDFYGRESEL---LATRQDLKSVEEKLSLAQEDLISNRNQIGnqnKLIQELKTAKATLEQ 1131
Cdd:pfam01576 616 ISARYAEERDRAEAEAREKETRALSLARALeeaLEAKEELERTNKQLRAEMEDLVSSKDDVG---KNVHELERSKRALEQ 692
|
730
....*....|....*..
gi 767975501 1132 DSAKKEQQLQERCKALQ 1148
Cdd:pfam01576 693 QVEEMKTQLEELEDELQ 709
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
414-607 |
1.93e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 43.02 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 414 EATQKLKEELSEVEtKYQHLKAEFKQLQQQREEKEQHGLQLQSeinqlhsklleTERQLGEAHGRLkeQRQLSSEKLMDK 493
Cdd:PRK04863 493 EAWDVARELLRRLR-EQRHLAEQLQQLRMRLSELEQRLRQQQR-----------AERLLAEFCKRL--GKNLDDEDELEQ 558
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 494 EQqvADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQalqqSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL 573
Cdd:PRK04863 559 LQ--EELEARLESLSESVSEARERRMALRQQLEQLQARIQRLA----ARAPAWLAAQDALARLREQSGEEFEDSQDVTEY 632
|
170 180 190
....*....|....*....|....*....|....
gi 767975501 574 LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQ 607
Cdd:PRK04863 633 MQQLLERERELTVERDELAARKQALDEEIERLSQ 666
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
882-1025 |
2.03e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 42.46 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 882 ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKtckelkhQLQvQMENTLKEQKELkksL 961
Cdd:PRK12704 37 EEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEK-------RLL-QKEENLDRKLEL---L 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 962 EKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELkqSSEQKKKQI-EALQGELK 1025
Cdd:PRK12704 106 EKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQELERISGL--TAEEAKEILlEKVEEEAR 168
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
402-560 |
2.03e-03 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 41.45 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 402 LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGrLKE 481
Cdd:COG1579 12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRN-NKE 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 482 QRQLSSEklmdkeqqVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI 560
Cdd:COG1579 91 YEALQKE--------IESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEEL 161
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
717-1153 |
2.16e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.45 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 717 ALQDKQQELNKITTQLDQVT-AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAdsLEVKASKEQALQDL 795
Cdd:COG4717 50 RLEKEADELFKPQGRKPELNlKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEE--LREELEKLEKLLQL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 796 QQQRQLNTDLELRATELSKQLEmekeivsstrlDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEElnnR 875
Cdd:COG4717 128 LPLYQELEALEAELAELPERLE-----------ELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEE---E 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 876 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGK-----------AAILDLEKTCKELKHQ-- 942
Cdd:COG4717 194 LQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERlkearlllliaAALLALLGLGGSLLSLil 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 943 ------------LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKqss 1010
Cdd:COG4717 274 tiagvlflvlglLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQ--- 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1011 eQKKKQIEALQGELKIAVLQKtELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATrqD 1090
Cdd:COG4717 351 -ELLREAEELEEELQLEELEQ-EIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEAL--D 426
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975501 1091 LKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS--AKKEQQLQERCKALQDIQKE 1153
Cdd:COG4717 427 EEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGelAELLQELEELKAELRELAEE 491
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
149-345 |
2.49e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 42.06 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 149 EELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSL- 227
Cdd:COG4942 27 AELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEEl 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 228 --REAAEQKVTRLT-----------EELNKEATVIQDLKTELLQRpgIEDVAVLKKELVQVQTLMDNMTLERERESEKLK 294
Cdd:COG4942 107 aeLLRALYRLGRQPplalllspedfLDAVRRLQYLKYLAPARREQ--AEELRADLAELAALRAELEAERAELEALLAELE 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 767975501 295 DECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQK 345
Cdd:COG4942 185 EERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAE 235
|
|
| RecN |
COG0497 |
DNA repair ATPase RecN [Replication, recombination and repair]; |
417-651 |
2.75e-03 |
|
DNA repair ATPase RecN [Replication, recombination and repair];
Pssm-ID: 440263 [Multi-domain] Cd Length: 555 Bit Score: 41.98 E-value: 2.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 417 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHS-KL-------LETERQLGEAHGRLKEQRQLSSE 488
Cdd:COG0497 154 EELLEEYREAYRAWRALKKELEELRADEAERARELDLLRFQLEELEAaALqpgeeeeLEEERRRLSNAEKLREALQEALE 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 489 KLMDKEQQVADLqlkLSRLEEQLKEKVTNSTELQHQLDKTkqqhqeqqalqQSTTAKLREAQNDLEQVLRQI-------G 561
Cdd:COG0497 234 ALSGGEGGALDL---LGQALRALERLAEYDPSLAELAERL-----------ESALIELEEAASELRRYLDSLefdperlE 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 562 DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLknqSESHKQAQENLH 641
Cdd:COG0497 300 EVEERLALLRRLARKYGVTVEELLAYAEELRAELAELENSDERLEELEAELAEAEAELLEAAEKL---SAARKKAAKKLE 376
|
250
....*....|
gi 767975501 642 DQVQEQKAHL 651
Cdd:COG0497 377 KAVTAELADL 386
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
544-930 |
2.98e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.06 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 544 AKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERE--DLYAKIQAGEGE----TAVLNQLQEKNHTLQE 617
Cdd:COG4717 81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQllPLYQELEALEAElaelPERLEELEERLEELRE 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 618 QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 697
Cdd:COG4717 161 LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAA 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 698 AAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQ-----DKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 772
Cdd:COG4717 241 LEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLgllalLFLLLAREKASLGKEAEELQALPALEELEEEE 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 773 QIKKLEADSLEVKASKEQALQDLQQQRQLNtDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKK 852
Cdd:COG4717 321 LEELLAALGLPPDLSPEELLELLDRIEELQ-ELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQE 399
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 853 ILKQ-----------DFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 921
Cdd:COG4717 400 LKEEleeleeqleelLGELEELLEALDEEELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELE 479
|
....*....
gi 767975501 922 NQKGKAAIL 930
Cdd:COG4717 480 ELKAELREL 488
|
|
| 46 |
PHA02562 |
endonuclease subunit; Provisional |
178-434 |
3.05e-03 |
|
endonuclease subunit; Provisional
Pssm-ID: 222878 [Multi-domain] Cd Length: 562 Bit Score: 41.92 E-value: 3.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 178 ELQSLEQQLEEAQTEnfnIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELnkEATVIQDLKTEll 257
Cdd:PHA02562 182 QIQTLDMKIDHIQQQ---IKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDEL--LNLVMDIEDPS-- 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 258 qrpgiEDVAVLKKELVQVQTLMDnmTLERERESEKLKDECKKLQSQYASSEATISQLR---SELAKGPQEVAVYVQELQK 334
Cdd:PHA02562 255 -----AALNKLNTAAAKIKSKIE--QFQKVIKMYEKGGVCPTCTQQISEGPDRITKIKdklKELQHSLEKLDTAIDELEE 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 335 LKSSVNELTQKNQTLTENLLKKEQDYTKLEEKhneesvsKKNIQATLhqkdldcQQLQSRLSASETSLHRIHVELSEKGE 414
Cdd:PHA02562 328 IMDEFNEQSKKLLELKNKISTNKQSLITLVDK-------AKKVKAAI-------EELQAEFVDNAEELAKLQDELDKIVK 393
|
250 260
....*....|....*....|
gi 767975501 415 ATQKLKEELSEVETKYQHLK 434
Cdd:PHA02562 394 TKSELVKEKYHRGIVTDLLK 413
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
342-682 |
3.50e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 41.43 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 342 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE 421
Cdd:COG4372 29 LSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQE 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 422 ELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 501
Cdd:COG4372 109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDEL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 502 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 581
Cdd:COG4372 189 LKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAIL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 582 SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSL 661
Cdd:COG4372 269 VEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLV 348
|
330 340
....*....|....*....|.
gi 767975501 662 ETSVNELNSQLNESKEKVSQL 682
Cdd:COG4372 349 GLLDNDVLELLSKGAEAGVAD 369
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
827-1352 |
3.52e-03 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 41.81 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 827 RLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELN----------------NRIQTTVTELQKVKMEK 890
Cdd:PRK01156 189 EEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNnlksalnelssledmkNRYESEIKTAESDLSME 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 891 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQvQMENTLKEQKELkkslekekEASHQ 970
Cdd:PRK01156 269 LEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEIN-KYHAIIKKLSVL--------QKDYN 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 971 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE----LKIAVLQKTELE---NKLQQQLT 1043
Cdd:PRK01156 340 DYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFiseiLKIQEIDPDAIKkelNEINVKLQ 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1044 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSD----FYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLI 1119
Cdd:PRK01156 420 DISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKI 499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1120 QELKTAKATLEQDSAKK----EQQLQERCKALQDIQ-KEKSLKEKEL----VNEKSKLAEIEEIKCRQEKEITKLN---- 1186
Cdd:PRK01156 500 VDLKKRKEYLESEEINKsineYNKIESARADLEDIKiKINELKDKHDkyeeIKNRYKSLKLEDLDSKRTSWLNALAvisl 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1187 ---EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEaklhsE 1263
Cdd:PRK01156 580 idiETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKID-----N 654
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1264 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVqnnqDERRALLERCLK 1343
Cdd:PRK01156 655 YKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRI----NDINETLESMKK 730
|
....*....
gi 767975501 1344 GEGEIEKLQ 1352
Cdd:PRK01156 731 IKKAIGDLK 739
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
966-1217 |
3.79e-03 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 41.82 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 966 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAvlqKTELENKLQQQLTQA 1045
Cdd:PRK11281 38 EADVQAQLDALNKQKLLEAEDKLVQQDLEQTLALLDKIDRQKEETEQLKQQLAQAPAKLRQA---QAELEALKDDNDEET 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1046 AQELaaekEKISVlqnnyeksqetfKQLqsdfygrESELLATRQDLKSVEEKLSLAQEDLISNRNQ-------IGNQNKL 1118
Cdd:PRK11281 115 RETL----STLSL------------RQL-------ESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQperaqaaLYANSQR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1119 IQE----LKTAKATLEQDSAKKEQQLQERCKAL--QDIQKEKSLKEKELVNE--KSKLAEIEEIKCRQEKEITKLNEELK 1190
Cdd:PRK11281 172 LQQirnlLKGGKVGGKALRPSQRVLLQAEQALLnaQNDLQRKSLEGNTQLQDllQKQRDYLTARIQRLEHQLQLLQEAIN 251
|
250 260 270
....*....|....*....|....*....|....*
gi 767975501 1191 SHKL----ESIKEITNLKDAKQL----LIQQKLEL 1217
Cdd:PRK11281 252 SKRLtlseKTVQEAQSQDEAARIqanpLVAQELEI 286
|
|
| Golgin_A5 |
pfam09787 |
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ... |
870-1035 |
4.60e-03 |
|
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.
Pssm-ID: 462900 [Multi-domain] Cd Length: 305 Bit Score: 40.90 E-value: 4.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 870 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQvQMEN 949
Cdd:pfam09787 50 EELRQERDLLREEIQKLRGQIQQLRTELQELEAQQQEEAESSREQLQELEEQLATERSARREAEAELERLQEELR-YLEE 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 950 TLKEQKELKKSLEKEKEAshqlklELNSMQEQLIQAQntlkQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 1029
Cdd:pfam09787 129 ELRRSKATLQSRIKDREA------EIEKLRNQLTSKS----QSSSSQSELENRLHQLTETLIQKQTMLEALSTEKNSLVL 198
|
....*.
gi 767975501 1030 QKTELE 1035
Cdd:pfam09787 199 QLERME 204
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
289-591 |
4.70e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 41.04 E-value: 4.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 289 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHN 368
Cdd:COG4372 39 ELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 369 EESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETkyQHLKAEFKQLQQQREEKE 448
Cdd:COG4372 119 ELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSE--AEAEQALDELLKEANRNA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 449 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKT 528
Cdd:COG4372 197 EKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEE 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 529 KQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 591
Cdd:COG4372 277 ELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAEL 339
|
|
| PHD2_KMT2A |
cd15590 |
PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A); KMT2A (also termed ALL-1, ... |
1400-1447 |
5.13e-03 |
|
PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A); KMT2A (also termed ALL-1, CXXC-type zinc finger protein 7, myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (Htrx), or zinc finger protein HRX) is a histone methyltransferase that belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2). It regulates chromatin-mediated transcription through the catalysis of methylation of histone 3 lysine 4 (H3K4), and is frequently rearranged in acute leukemia. KMT2A functions as the catalytic subunit in the MLL1 complex, which also contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex. The MLL1 complex is highly active and specific for H3K4 methylation. KMT2A contains a CxxC (x for any residue) zinc finger domain, three plant homeodomain (PHD) fingers, a Bromodomain domain, an extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain. This model corresponds to the second PHD finger.
Pssm-ID: 277065 Cd Length: 50 Bit Score: 36.54 E-value: 5.13e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 767975501 1400 CMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALT-PSSKKPVRVCDAC 1447
Cdd:cd15590 2 CHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTkPTKKKRVWICTKC 50
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
637-842 |
5.25e-03 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 40.97 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 637 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQN 716
Cdd:COG3883 18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYR 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 717 ALQD--------KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 788
Cdd:COG3883 98 SGGSvsyldvllGSESFSDFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQ 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 767975501 789 EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 842
Cdd:COG3883 178 AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
126-1025 |
5.35e-03 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 41.31 E-value: 5.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 126 DVTLLRQEVQDLQASLkeekwysEELKKELEKYQglqqqeakpdglvtdssAELQSLEQQLEEAQTENFNIkqmkdlfEQ 205
Cdd:pfam01576 216 ESTDLQEQIAELQAQI-------AELRAQLAKKE-----------------EELQAALARLEEETAQKNNA-------LK 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 206 KAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKeatviqdLKTELLQrpgIEDVAVLKKELVQvqtlmdnmtlE 285
Cdd:pfam01576 265 KIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEA-------LKTELED---TLDTTAAQQELRS----------K 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 286 RERESEKLKdecKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNE----LTQKNQTLTENLLKKEQDYT 361
Cdd:pfam01576 325 REQEVTELK---KALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKakqaLESENAELQAELRTLQQAKQ 401
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 362 KLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQhlkaefkQLQ 441
Cdd:pfam01576 402 DSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQ-------DTQ 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 442 QQREEKEQHGLQLQSEInqlhsklleteRQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL 521
Cdd:pfam01576 475 ELLQEETRQKLNLSTRL-----------RQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEAL 543
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 522 QHQLDKTKQQHQEQQALQQSTTA---KLREAQNDLEQVLRQIG-DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 597
Cdd:pfam01576 544 EEGKKRLQRELEALTQQLEEKAAaydKLEKTKNRLQQELDDLLvDLDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEE 623
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 598 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKahlrAAQDRVLSLETSVNELNSQLNESKE 677
Cdd:pfam01576 624 RDRAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSKD----DVGKNVHELERSKRALEQQVEEMKT 699
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 678 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKittQLDQVTAKLQDKQEHCSQ-------LE 750
Cdd:pfam01576 700 QLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDEQGEEKRRQLVK---QVRELEAELEDERKQRAQavaakkkLE 776
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 751 SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLemekeivsstrldL 830
Cdd:pfam01576 777 LDLKELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAEL-------------L 843
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 831 QKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEElnNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 910
Cdd:pfam01576 844 QLQEDLAASERARRQAQQERDELADEIASGASGKSALQDEK--RRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQ 921
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 911 LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQvQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQliQAQNTLK 990
Cdd:pfam01576 922 LTTELAAERSTSQKSESARQQLERQNKELKAKLQ-EMEGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQ--AANKLVR 998
|
890 900 910
....*....|....*....|....*....|....*
gi 767975501 991 QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 1025
Cdd:pfam01576 999 RTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMK 1033
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
459-637 |
5.94e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 40.66 E-value: 5.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 459 NQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 538
Cdd:COG4372 2 DRLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 539 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE----TAVLNQLQEKNHT 614
Cdd:COG4372 82 LEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEiaerEEELKELEEQLES 161
|
170 180
....*....|....*....|...
gi 767975501 615 LQEQVTQLTEKLKNQSESHKQAQ 637
Cdd:COG4372 162 LQEELAALEQELQALSEAEAEQA 184
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
469-691 |
5.99e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 41.44 E-value: 5.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 469 ERQLGEAHGRLKEQRqlssEKLMDKEQQVADLQLKLSRLEeQLKEKVTNSTELQHQLDktkqqhqeqqalqqstTAKLRE 548
Cdd:COG4913 220 EPDTFEAADALVEHF----DDLERAHEALEDAREQIELLE-PIRELAERYAAARERLA----------------ELEYLR 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 549 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE-----TAVLNQLQEKNHTLQEQVTQLT 623
Cdd:COG4913 279 AALRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQirgngGDRLEQLEREIERLERELEERE 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767975501 624 EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTE 691
Cdd:COG4913 359 RRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEA 426
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
130-1161 |
6.02e-03 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 41.31 E-value: 6.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 130 LRQEVQDLQASLKEEKWYSEELKKELEKYQglqqqeakpdglvtdssAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQ 209
Cdd:pfam01576 73 LEEILHELESRLEEEEERSQQLQNEKKKMQ-----------------QHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKK 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 210 LATEI---ADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEllQRPGIEDVAV-LKKElvqvqtlmDNMTLE 285
Cdd:pfam01576 136 LEEDIlllEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNK--HEAMISDLEErLKKE--------EKGRQE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 286 RERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYtklee 365
Cdd:pfam01576 206 LEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDL----- 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 366 khneESVSKKNIQATLHQKDLdcqqlqsrlsasETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKqlqqqrE 445
Cdd:pfam01576 281 ----ESERAARNKAEKQRRDL------------GEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALE------E 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 446 EKEQHGLQLQsEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLmdkEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 525
Cdd:pfam01576 339 ETRSHEAQLQ-EMRQKHTQALEELTEQLEQAKRNKANLEKAKQAL---ESENAELQAELRTLQQAKQDSEHKRKKLEGQL 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 526 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKeniSLLEKEREDLYAKIQAGEGETAVL 605
Cdd:pfam01576 415 QELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLE---SQLQDTQELLQEETRQKLNLSTRL 491
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 606 NQLQEKNHTLQEQVTQLTEKLKN---QSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLnesKEKVSQL 682
Cdd:pfam01576 492 RQLEDERNSLQEQLEEEEEAKRNverQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQL---EEKAAAY 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 683 DIQIKAKTELLLSAEAAKTAqradlQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEhcsQLESHLKEYKEKYLS 762
Cdd:pfam01576 569 DKLEKTKNRLQQELDDLLVD-----LDHQRQLVSNLEKKQKKFDQMLAEEKAISARYAEERD---RAEAEAREKETRALS 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 763 LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQkkseALESIKQ 842
Cdd:pfam01576 641 LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQ----ATEDAKL 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 843 KLtkqEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKvsdSLKNSKSEFEKEN 922
Cdd:pfam01576 717 RL---EVNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLEL---DLKELEAQIDAAN 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 923 QKGKAAILDLEKtckelkhqLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 1002
Cdd:pfam01576 791 KGREEAVKQLKK--------LQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQE 862
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1003 INELKQSSEQKKKQIEALQGELKIAVLQKTELEnklqqqltqaaQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRES 1082
Cdd:pfam01576 863 RDELADEIASGASGKSALQDEKRRLEARIAQLE-----------EELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERS 931
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 1083 ellaTRQDLKSVEEKLSLAQEDLISNRNQIGNQNKliQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKEL 1161
Cdd:pfam01576 932 ----TSQKSESARQQLERQNKELKAKLQEMEGTVK--SKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKL 1004
|
|
| PRK10929 |
PRK10929 |
putative mechanosensitive channel protein; Provisional |
159-513 |
6.36e-03 |
|
putative mechanosensitive channel protein; Provisional
Pssm-ID: 236798 [Multi-domain] Cd Length: 1109 Bit Score: 41.19 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 159 QGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMK---DLFEQKAAQLATEIADIKskyDEERSLRE-----A 230
Cdd:PRK10929 30 QELEQAKAAKTPAQAEIVEALQSALNWLEERKGSLERAKQYQqviDNFPKLSAELRQQLNNER---DEPRSVPPnmstdA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 231 AEQKV----TRLTEE---LNKEATVIQDLKTELLQRPGIEDVAvlKKELVQV----QTLMDNMTLERERESEKLKDECKK 299
Cdd:PRK10929 107 LEQEIlqvsSQLLEKsrqAQQEQDRAREISDSLSQLPQQQTEA--RRQLNEIerrlQTLGTPNTPLAQAQLTALQAESAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 300 LQSQY---------ASSEATISQLRSELAKgpQEVAVYVQELQKLKSSVNELTQKNQTL----TENLLKKEQDytkLEEK 366
Cdd:PRK10929 185 LKALVdelelaqlsANNRQELARLRSELAK--KRSQQLDAYLQALRNQLNSQRQREAERalesTELLAEQSGD---LPKS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 367 HNEESVSKKNIQATLHQ--KDLDCQQLQSRLSASET-----SLHRIHVE---LSEK---GEATQKLKEELSEVeTKYQHL 433
Cdd:PRK10929 260 IVAQFKINRELSQALNQqaQRMDLIASQQRQAASQTlqvrqALNTLREQsqwLGVSnalGEALRAQVARLPEM-PKPQQL 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 434 KAEFKQLQQQR------EEKEQHGLQLQSEINQlhsKLLETERQLGEAhgRLKEQRQLSSEKLMDKEQQVADL-QLKL-- 504
Cdd:PRK10929 339 DTEMAQLRVQRlryedlLNKQPQLRQIRQADGQ---PLTAEQNRILDA--QLRTQRELLNSLLSGGDTLILELtKLKVan 413
|
....*....
gi 767975501 505 SRLEEQLKE 513
Cdd:PRK10929 414 SQLEDALKE 422
|
|
| ClpA |
COG0542 |
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ... |
177-287 |
6.51e-03 |
|
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 41.22 E-value: 6.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 177 AELQSLEQQLEEAQTENFNIKQMKDLFEQ-KAAQLATEIADIKSKYDEERSLREAAEQKVTRlteelnkeatvIQDLKTE 255
Cdd:COG0542 411 EELDELERRLEQLEIEKEALKKEQDEASFeRLAELRDELAELEEELEALKARWEAEKELIEE-----------IQELKEE 479
|
90 100 110
....*....|....*....|....*....|...
gi 767975501 256 LLQRPGieDVAVLKKELVQVQT-LMDNMTLERE 287
Cdd:COG0542 480 LEQRYG--KIPELEKELAELEEeLAELAPLLRE 510
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
804-1399 |
7.05e-03 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 40.87 E-value: 7.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 804 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALEsikqkltkQEEEKKILKQDFETLSQEtkiqheELNNRIQTTVTEL 883
Cdd:pfam15921 89 DLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQ--------MERDAMADIRRRESQSQE------DLRNQLQNTVHEL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 884 QKVKMEKEALMTELSTVKDKLSKVSDSlknskseFEKENQKGKAAILDLEKTCKELKHQlqvQMENTLKEQKELKKSLEK 963
Cdd:pfam15921 155 EAAKCLKEDMLEDSNTQIEQLRKMMLS-------HEGVLQEIRSILVDFEEASGKKIYE---HDSMSTMHFRSLGSAISK 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 964 ekeASHQLKLELNSMQEQLIQAQNTLKQNEKEEQqlqgniNELKQSSEQKKKQIEALQGELKIAVLQKTElenklqqqlt 1043
Cdd:pfam15921 225 ---ILRELDTEISYLKGRIFPVEDQLEALKSESQ------NKIELLLQQHQDRIEQLISEHEVEITGLTE---------- 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1044 qaaqELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISN-RNQIGNQNKLIQEL 1122
Cdd:pfam15921 286 ----KASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEElEKQLVLANSELTEA 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1123 KTAKATLEQDSAKKEQQLQercKALQDIQKekslKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1202
Cdd:pfam15921 362 RTERDQFSQESGNLDDQLQ---KLLADLHK----REKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEAL 434
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1203 LKDAKQ----LLIQQKLELQGKADSLK---AAVEQEKRNQQILKDQVKKEEEELKKEFIEKE--AKLHSEIKEKEVGMKK 1273
Cdd:pfam15921 435 LKAMKSecqgQMERQMAAIQGKNESLEkvsSLTAQLESTKEMLRKVVEELTAKKMTLESSERtvSDLTASLQEKERAIEA 514
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1274 HEENEAKLTMQI----------TALNENLGTVKKEWQSSQRRVSELEKQTDDLR-----------------GEIAVLEAT 1326
Cdd:pfam15921 515 TNAEITKLRSRVdlklqelqhlKNEGDHLRNVQTECEALKLQMAEKDKVIEILRqqienmtqlvgqhgrtaGAMQVEKAQ 594
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767975501 1327 VQNNQDERRALLERCL----KGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQN 1399
Cdd:pfam15921 595 LEKEINDRRLELQEFKilkdKKDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNS 671
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
439-981 |
7.12e-03 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 40.88 E-value: 7.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 439 QLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEqrqlsseklmdkeqqvadLQLKLSRLEEQLKEKVTNS 518
Cdd:pfam05557 10 RLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQE------------------LQKRIRLLEKREAEAEEAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 519 ---TELQHQLDKTKQQHQEQQALQQSTTAKLREAQ----NDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEK---ER 588
Cdd:pfam05557 72 reqAELNRLKKKYLEALNKKLNEKESQLADAREVIsclkNELSELRRQIQRAELELQSTNSELEELQERLDLLKAkasEA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 589 EDLYAKIQAGEGETAVLNQ-LQEKNHTLQEQVTQLTEKLKNQSESHKQAQ-ENLHDQVQEQKAHLRAAQDRVLSLETSVN 666
Cdd:pfam05557 152 EQLRQNLEKQQSSLAEAEQrIKELEFEIQSQEQDSEIVKNSKSELARIPElEKELERLREHNKHLNENIENKLLLKEEVE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 667 ELNSQLN---ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN------KITTQLDQVTA 737
Cdd:pfam05557 232 DLKRKLEreeKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVlkeensSLTSSARQLEK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 738 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEgqiKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL--RATELSKQ 815
Cdd:pfam05557 312 ARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQ---RRVLLLTKERDGYRAILESYDKELTMSNYSPQLleRIEEAEDM 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 816 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQE-TKIQHEELNNRIQTTVTELQKVKMEKEALm 894
Cdd:pfam05557 389 TQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQALRQQESLADPSySKEEVDSLRRKLETLELERQRLREQKNEL- 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 895 tELSTVKDKLSKVSDsLKNSKSEFEKENQKGKAaildlektcKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 974
Cdd:pfam05557 468 -EMELERRCLQGDYD-PKKTKVLHLSMNPAAEA---------YQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLPET 536
|
....*..
gi 767975501 975 LNSMQEQ 981
Cdd:pfam05557 537 TSTMNFK 543
|
|
| ClpA |
COG0542 |
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ... |
937-1027 |
7.21e-03 |
|
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 40.84 E-value: 7.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 937 KELKHQL-QVQMEntlkeqkelKKSLEKEKEASHQLKL-ELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 1014
Cdd:COG0542 414 DELERRLeQLEIE---------KEALKKEQDEASFERLaELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRY 484
|
90
....*....|...
gi 767975501 1015 KQIEALQGELKIA 1027
Cdd:COG0542 485 GKIPELEKELAEL 497
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
280-575 |
7.29e-03 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 40.88 E-value: 7.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 280 DNMTLERERESEKLKDECKKLQSQyasseatisQLRSElakgpqEVAVYVQELQKLKSSVNELTQKNQTLTENlLKKEQD 359
Cdd:pfam17380 340 ERMAMERERELERIRQEERKRELE---------RIRQE------EIAMEISRMRELERLQMERQQKNERVRQE-LEAARK 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 360 YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS--LHRIHVELSEKGEATQKLKEElsEVETKYQHLKAEF 437
Cdd:pfam17380 404 VKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAreMERVRLEEQERQQQVERLRQQ--EEERKRKKLELEK 481
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 438 KQLQQQREEkEQHGLQLQSEINQLHSKLLETERqlgeahgrlkeQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK-VT 516
Cdd:pfam17380 482 EKRDRKRAE-EQRRKILEKELEERKQAMIEEER-----------KRKLLEKEMEERQKAIYEEERRREAEEERRKQQeME 549
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 767975501 517 NSTELQHQLDKTKQQHQEQqalqqsttaklrEAQNDLEQVLRQIGDKDQKIQNLEALLQ 575
Cdd:pfam17380 550 ERRRIQEQMRKATEERSRL------------EAMEREREMMRQIVESEKARAEYEATTP 596
|
|
| PRK09039 |
PRK09039 |
peptidoglycan -binding protein; |
391-511 |
7.98e-03 |
|
peptidoglycan -binding protein;
Pssm-ID: 181619 [Multi-domain] Cd Length: 343 Bit Score: 40.33 E-value: 7.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 391 LQSRLSASETSLHRIHVELSEkgeatqkLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 470
Cdd:PRK09039 44 LSREISGKDSALDRLNSQIAE-------LADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAEG 116
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 767975501 471 QLGEAHGRLKEQRQLSSEKLmdkeQQVADLQLKLSRLEEQL 511
Cdd:PRK09039 117 RAGELAQELDSEKQVSARAL----AQVELLNQQIAALRRQL 153
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
731-911 |
8.01e-03 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 40.58 E-value: 8.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 731 QLDQVTAKLQDKQ----EHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADsLEVKASKEQALQDLQQQRQLNtdlE 806
Cdd:PRK00409 517 KLNELIASLEELEreleQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEE-AEKEAQQAIKEAKKEADEIIK---E 592
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 807 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKI--------LKQDFETLSQETKIQHEELNNRIQT 878
Cdd:PRK00409 593 LRQLQKGGYASVKAHELIEARKRLNKANEKKEKKKKKQKEKQEELKVgdevkylsLGQKGEVLSIPDDKEAIVQAGIMKM 672
|
170 180 190
....*....|....*....|....*....|....*
gi 767975501 879 TV--TELQKVKMEKEALMTELSTVKDKLSKVSDSL 911
Cdd:PRK00409 673 KVplSDLEKIQKPKKKKKKKPKTVKPKPRTVSLEL 707
|
|
| COG2433 |
COG2433 |
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]; |
1262-1379 |
8.66e-03 |
|
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
Pssm-ID: 441980 [Multi-domain] Cd Length: 644 Bit Score: 40.61 E-value: 8.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1262 SEIKEKEVGmKKHEENEAKLTMQITALNENLGTVKKewqsSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE---RRALL 1338
Cdd:COG2433 383 EELIEKELP-EEEPEAEREKEHEERELTEEEEEIRR----LEEQVERLEAEVEELEAELEEKDERIERLERElseARSEE 457
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 767975501 1339 ERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSL 1379
Cdd:COG2433 458 RREIRKDREISRLDREIERLERELEEERERIEELKRKLERL 498
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1008-1230 |
9.34e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 40.13 E-value: 9.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1008 QSSEQKKKQIEALQGELKiavlQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1087
Cdd:COG4942 20 DAAAEAEAELEQLQQEIA----ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975501 1088 RQDLKSVEEKLSlaqeDLISNRNQIGNQNKLIQELKTAKAtleQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1167
Cdd:COG4942 96 RAELEAQKEELA----ELLRALYRLGRQPPLALLLSPEDF---LDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767975501 1168 LAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ 1230
Cdd:COG4942 169 LEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
|
|
| |
