|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
1-359 |
0e+00 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 604.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:TIGR00892 98 MILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFL 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKikTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFL 160
Cdd:TIGR00892 178 ILGGLLLHCCVCGALMRPVGPSQRVSKSKSKEGLPPDGSTKKL--SKKSTAEKINRFLDFSLFTHRGFLVYLSGNVIMFL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:TIGR00892 256 GFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTHLLCALAGDYTG 335
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:TIGR00892 336 LVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGL 415
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 767975949 321 WLLIGNAINYRLLAKERKEENARQKTRESEPL-SKSKHSE 359
Cdd:TIGR00892 416 FLAIGNYINYRLLAKEQKAALEREGARDKKDAeGDSRESE 455
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
1-326 |
1.94e-180 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 505.50 E-value: 1.94e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLGPnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17427 162 ILGGLLLNCCVAGSLMRPLGP----------------------------------------LFKHRGFLIYLSGNVIMFL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17427 202 GFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17427 282 LVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASI 361
|
....*.
gi 767975949 321 WLLIGN 326
Cdd:cd17427 362 WLFIGN 367
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
1-325 |
6.36e-143 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 410.42 E-value: 6.36e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17426 82 LIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLGPNqttsksknktgkteddsspkkiktkkstwekvnKYLDFSLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17426 162 ILGGLLLNCCVAGSLMRPIGPK---------------------------------PFLDLTLFTHRGFLLYLSGNVIMFF 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17426 209 GLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVG 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17426 289 FCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSI 368
|
....*
gi 767975949 321 WLLIG 325
Cdd:cd17426 369 YLFIG 373
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
1-326 |
2.17e-113 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 335.16 E-value: 2.17e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17430 82 MILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGFL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLgpnqttsksknktgkteddsspkkiktkkstwekvnkylDFSLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17430 162 ILGGLLLNCCTCGAVMRPL---------------------------------------DFSVFRDRGFVIYTIAKFIMVL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17430 203 GLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGG 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17430 283 LVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSAL 362
|
....*.
gi 767975949 321 WLLIGN 326
Cdd:cd17430 363 FLALGN 368
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
1-324 |
6.46e-91 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 277.51 E-value: 6.46e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17352 82 LLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17352 162 ILGGLCLNLCVCGLLLR--------------------------------------------LLKDPTFVLLALGVSFAML 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRprIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17352 198 GFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIG--RLYLYIFTLLILGLSLLAFPLATTYVG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17352 276 LIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGV 355
|
....
gi 767975949 321 WLLI 324
Cdd:cd17352 356 LLFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
1-324 |
6.03e-82 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 254.70 E-value: 6.03e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17425 82 MVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfslFKHRGFLIYLSGNVIMFL 160
Cdd:cd17425 162 VFGGVLLNCCVCGAVMRPF-------------------------------------------CSNTRYQIYTLGVTWMVL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17425 199 GFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17425 279 LLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAAL 358
|
....
gi 767975949 321 WLLI 324
Cdd:cd17425 359 FMGL 362
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
1-323 |
3.73e-65 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 211.87 E-value: 3.73e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17423 82 FLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLGpnqttsksknktgkTEDDSSpkkiktkkSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17423 162 LLSALSLHLVPCGALLRPLA--------------LPGDPP--------APPRSLSAAFGLSLLTHRAFLRYALATTLINT 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPriQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17423 220 GYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRL--LHLLVLWTALTGLSLLLLPLAKVYGS 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17423 298 LLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSL 377
|
...
gi 767975949 321 WLL 323
Cdd:cd17423 378 ILL 380
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
1-322 |
2.03e-54 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 183.41 E-value: 2.03e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17422 162 VVGALQLNIVVCGALLR--------------------------------------------VLKEPGFICYALFGLFATL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRpRIQYFFSFAIMFnGVCHLLCPLAQDYTS 240
Cdd:cd17422 198 GFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILL-CVVLLLFPFAYGFWS 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLM--DLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAA 318
Cdd:cd17422 276 LLVCSIFYGFMFGTVAGTHIPLLAedDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALG 355
|
....
gi 767975949 319 SVWL 322
Cdd:cd17422 356 AVFL 359
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
1-322 |
5.82e-46 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 161.13 E-value: 5.82e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17424 82 LILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldFSLFKhrGFLIYLSGNVIMFL 160
Cdd:cd17424 162 ILGGFVLNLCVCGALMR------------------------------------------FLLMP--DFLVLAVSVLFLAY 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17424 198 GCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17424 278 LVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSL 357
|
..
gi 767975949 321 WL 322
Cdd:cd17424 358 LL 359
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
2-324 |
4.68e-37 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 137.65 E-value: 4.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 2 VLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSsLAPFNQYLFNTFGWKGSFLI 81
Cdd:cd17421 83 LISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFA-LAPFTQLLLDEYDWQGALLI 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 82 LGSLLLNACVAGSLMRPLgpnqttsksknktgkteddsspkkiktkkstwekvnkylDFSLFKHRGFLIYLSGNVIMFLG 161
Cdd:cd17421 162 FGGIMLNLVASGMLLRPI---------------------------------------DFSLLKDPFFCIYTWSFVFSQLA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 162 FFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRpRIQYFFSFAIMFnGVCHLLCPLAQDYTSL 241
Cdd:cd17421 203 YFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIK-KYHYHKAYLILC-GVTNLLAPLATTYPLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 242 VLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW 321
Cdd:cd17421 281 MTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVS 360
|
...
gi 767975949 322 LLI 324
Cdd:cd17421 361 FFL 363
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
1-304 |
1.97e-29 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 117.24 E-value: 1.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17420 87 LLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLR 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLGPNQTTSKSKnktgkteddssPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17420 167 VLSLFMFVLILCSFTYRPLHPSPEDPKSK-----------PGRRTLHSRINLFLRKIFNVEIFKRKRYVIWALGIPLALF 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIqYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17420 236 GYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKM-YLQVLSFVSIGLMSMMIPLCNSFGI 314
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEY 304
Cdd:cd17420 315 LISVCLVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSY 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
1-324 |
1.80e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 108.81 E-value: 1.80e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYFY-RKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 79
Cdd:COG2223 84 LLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 80 LILGSLLLNACVAGSLMrplgpnqttsksknktGKTEDDSSPKKIKTKKSTWekvnkyldFSLFKHRGFLIYLSGNVIMF 159
Cdd:COG2223 163 LILGILLLVVAVLAWLF----------------LRDPPAGAAAAAKASLRDQ--------LEALRDPRFWLLSLLYFGTF 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 160 LGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLLCPLAQ-D 237
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSD--RIGGRRVLLIVFALM--ALGLLLLALALgS 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 238 YTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVA 317
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV 374
|
....*..
gi 767975949 318 ASVWLLI 324
Cdd:COG2223 375 ALVLTLL 381
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
2-324 |
2.09e-26 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 108.38 E-value: 2.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 2 VLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLI 81
Cdd:cd17429 83 VLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFI 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 82 LGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFLG 161
Cdd:cd17429 163 QGAVSLNLCVCGALMR--------------------------------------------LFTNKVFVAFIFWALFAYCS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 162 FFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIANSKYIrpRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17429 199 FVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCI--SVWNVFILANFTLGVCILILPLMHTYTG 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGL--GFGSVSSVLFEtlmDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAA 318
Cdd:cd17429 277 LAIVCALIGFssGYFSLMPVVTE---DLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVG 353
|
....*.
gi 767975949 319 SVWLLI 324
Cdd:cd17429 354 IICLLL 359
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
1-304 |
3.31e-25 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 105.64 E-value: 3.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17464 87 LLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGLFNTLR 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPLGPNQttsksknktgkteDDSSPKKIKTKKSTwekVNKYLDFSLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17464 167 VLCIFMFVLFLAGFTYKPLVPMK-------------KDKEGKKRKFKCPP---LKKIFNFNIWKSTGYRIWAFGIPAALF 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIrPRIQ--YFFSFAIMFNGVCHLLCPLAQDY 238
Cdd:cd17464 231 GYFVPYVHLMNHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVAD--YI-PGVKkvYLQVSSFFFIGLMSMMIPLCHVF 307
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767975949 239 TSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEY 304
Cdd:cd17464 308 GGLIAVCLFMGLFDGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSY 373
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-325 |
1.34e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 94.55 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 79
Cdd:COG2271 89 TLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKeRGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 80 LILGSLLLNACVAGslmrplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfslfkhrgFLIYLSGNVIMF 159
Cdd:COG2271 168 LILGLPGLLLALLR------------------------------------------------------FWLLALAYFLVY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 160 LGFFAPIIFLAPYAKD-QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMfnGVCHLLCPLAQDY 238
Cdd:COG2271 194 FALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLA--ALALLLLALLPSP 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 239 TSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAA 318
Cdd:COG2271 272 ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA 351
|
....*..
gi 767975949 319 SVWLLIG 325
Cdd:COG2271 352 LLALLLL 358
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-328 |
4.95e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 90.70 E-value: 4.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFItGLGLAFnLQPALT-IIGKYFYRKRPMANGL---AMAGSPVFLSSLAPFnqyLFNTFGWK 76
Cdd:COG2807 97 LLLRSLAPSVALLLAGTALI-GAGIAV-GNVLLPgLIKRWFPDRVGLMTGLytaAMGLGAALAAGLTVP---LAAALGWR 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 77 GSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKteddsspkkiktkkstwekvnkyldfSLFKHRGFLIYLSGNV 156
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLR--------------------------SLWRSPLAWLLTLFFG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 157 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIAnSKYIRPRIQYFFSFAIMFNGVCHLLcpLAQ 236
Cdd:COG2807 226 LQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLA-DRLGDRRPLLLLLGLLGLAGLLGLL--LAP 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 237 DyTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAvgLVTIVECGPVLL---GPPLAGKLVDLTGEYKY--MYMSC 311
Cdd:COG2807 303 G-SLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAA--LSGMAQSVGYLLaalGPLLVGALHDATGSWTAalLLLAA 379
|
330
....*....|....*..
gi 767975949 312 GAIVVAASVWLLIGNAI 328
Cdd:COG2807 380 LAVLMLVAGLLAGRPYV 396
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
2-323 |
7.60e-20 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 90.02 E-value: 7.60e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 2 VLASFSSSVVQLYLTMGFITGLGLAFNLQPA-LTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17355 83 VLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRPlgpnqttsksknktgkteDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17355 163 VLALLALLVLVPVLLLLR------------------RRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGF 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqyffSFAIMFNGVCHLLCPLA--QDY 238
Cdd:cd17355 225 AVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD-RYSPRRL----LAASYALRALGLALLLLlpFPP 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 239 TSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAA 318
Cdd:cd17355 300 LALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIA 379
|
....*
gi 767975949 319 SVWLL 323
Cdd:cd17355 380 ALLVL 384
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-291 |
1.09e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.93 E-value: 1.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 79
Cdd:pfam07690 76 LLLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEeRGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 80 LILGSLLLNACVAGSLMRPlgpnqttsksknktgkteddsSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMF 159
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRP---------------------PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 160 LGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFnGVCHLLCPLAQDYT 239
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA-ALGLLLLSLTLSSL 292
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 767975949 240 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGP 291
Cdd:pfam07690 293 WLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-282 |
3.29e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.94 E-value: 3.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 79
Cdd:COG2814 89 SLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 80 LILGSLLLNACVAGSLMRPlgpnqttsksknktgktedDSSPKKIKTKKSTWekvnkyldFSLFKHRGFLIYLSGNVIMF 159
Cdd:COG2814 168 LVNAVLALLALLLLLRLLP-------------------ESRPAARARLRGSL--------RELLRRPRLLLLLLLAFLLG 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 160 LGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIqyFFSFAIMfnGVCHLLCPLAQDY 238
Cdd:COG2814 221 FGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLL--LIGLLLL--ALGLLLLALAGSL 296
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 767975949 239 TSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIV 282
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
1-324 |
3.60e-17 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 81.79 E-value: 3.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17428 82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGSLLLNACVAGSLMRplgpnqttsksknktgkteddsspkkiktkkstwekvnkyldfsLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17428 162 IVGALALNLLACGSLMR--------------------------------------------LFKNRVFSALFIAILLFDI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAF-LLSVMAFVDMFARPSVGLIANSKYIRPriQYFFSFAIMFNGVCHLLCPLAQDYT 239
Cdd:cd17428 198 GAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWVNS--LYLYVLTLIGMGAALLAIPFAKSYL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 240 SLVLYAVFFGLGFGSVSSVLFETlMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAAS 319
Cdd:cd17428 276 TLAVLSAILGFLSGNWSIFPYVT-TKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGG 354
|
....*
gi 767975949 320 VWLLI 324
Cdd:cd17428 355 FLLLL 359
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
4-304 |
6.28e-15 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 75.22 E-value: 6.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 4 ASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILG 83
Cdd:cd17465 90 SSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGLAHTFQVLS 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 84 SLLLNACVAGslmrplgpnqttsksknktgkteddsspkkiktkkstwekvnkyLDFSLFKHRGFLIYLSGNVIMFLGFF 163
Cdd:cd17465 170 LFMFIQIFLS--------------------------------------------LTYKVFRRKTYRIWAFGIATAVLGYF 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 164 APIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANS----KYIRPRIQYFFSFAIMfngvcHLLCPLAQDYT 239
Cdd:cd17465 206 VPYVHLMKYVEEEFKENKREWVLLVCIGASSGIGRLMSGKIGDLipglKKIYLQVASFLLLGIM-----SMMIPLCQVFE 280
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767975949 240 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEY 304
Cdd:cd17465 281 GVIVVCLFLGLCDGCFITIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSY 345
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
1-324 |
9.39e-15 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 74.95 E-value: 9.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGspVFLSSL--APFNQYLFNTFGWKGS 78
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAG--FGLGSLifSPLIAYLINTVGVPTT 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 79 FLILGSL-LLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSpkkiktKKSTWEkvnkyldfSLFKHRGFLIYLSgnvi 157
Cdd:cd17353 160 FLILGIIfLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPR------DYTPRE--------MLRTPTFWLLWLM---- 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 158 MFLGFFAPIIF---LAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAImfNGVCHLLCP 233
Cdd:cd17353 222 FFLNATAGLMLigqAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWL--SDKIGRKNTLSIAFLI--QGVAMFLLP 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 234 LAQDYTSL-VLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGkLVDLTGEYKY-MYMSC 311
Cdd:cd17353 298 FIGSVAVLfVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAaFIIAA 376
|
330
....*....|...
gi 767975949 312 GAIVVAASVWLLI 324
Cdd:cd17353 377 ALSLVALALALLL 389
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-325 |
2.69e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 73.38 E-value: 2.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSF 79
Cdd:cd17325 75 TLLFAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPF 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 80 LILGSLLLNACVAGSLMRPlgpnqTTSKSKNKTGKTEDDSSPKKIKtkkstwekvnkyldfsLFKHRGFLIYLSGNVIMF 159
Cdd:cd17325 154 LVCAALALLALVLALLLLP-----EPRPPPNKRAVSAARLRSGLRL----------------LLRDRRLLALFLAIFVLA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 160 LGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLLCPLAQDY 238
Cdd:cd17325 213 FAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSD--RIGRKPLILIGLLLS--AVALLLLPLATSF 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 239 TSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAA 318
Cdd:cd17325 289 WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLA 367
|
....*..
gi 767975949 319 SVWLLIG 325
Cdd:cd17325 368 AVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
141-353 |
4.69e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 72.31 E-value: 4.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 141 SLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPriqyFFSF 220
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR----VLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 221 AIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDL 300
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 767975949 301 TGeYKYMYMSCGAIVVAASVWLlignainYRLLAKERKEENARQKTRESEPLS 353
Cdd:COG2814 161 FG-WRWVFLVNAVLALLALLLL-------LRLLPESRPAARARLRGSLRELLR 205
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-320 |
3.29e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.15 E-value: 3.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRK-RPMANGLAMAGSPVFLSSLAPFNQYLF--NTFGWKG 77
Cdd:cd06174 75 ALLFAFAPSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRA 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 78 SFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTeddsspkkikTKKSTWEkvnkyldfsLFKHRGFLIYLSGNVI 157
Cdd:cd06174 154 VFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKS----------VLKLLKR---------VLKNPGLWLLLLAIFL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 158 MFLGFFAPIIFLAPYAKDQG-IDEYSAAFLLSVMAFVDMFARPSVGLIAnSKYIRPRIQYFFSFAIMfnGVCHLLCPLAQ 236
Cdd:cd06174 215 VNLAYYSFSTLLPLFLLDLGgLSVAVAGLLLSLFGLAGALGSLLLGLLS-DRLIGRKPLLLIGLLLM--ALGLALLLLAP 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 237 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVV 316
Cdd:cd06174 292 SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
....
gi 767975949 317 AASV 320
Cdd:cd06174 372 LAAI 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-324 |
1.45e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 19 FITGLGLAFNLQPALTIIGKYF---YRKRPMA-NGLAMAGSPVFLSSLAPFnqylFNTFGWKGSFLI-LGSLLLNACVAG 93
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFegeERAKMLGlQSAAMSLGGVVFLLLGGA----LAEIGWRAPFLVyLLALPVLILVLL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 94 SLMRPlgpnQTTSKSKNKTGKTEDDSSPKKiktkkstwekvnkyldfslfkhRGFLIYLSGNVIMFLgFFAPIIFLAPYA 173
Cdd:cd17473 172 FLPEP----ARKSKSAASPGAATAAALPWK----------------------RVLPIYFLAFLAMLL-FYVIPIQLPFLL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 174 KDQGI-DEYSAAFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGF 252
Cdd:cd17473 225 QERGGgSAALIGLALAIASLAGAIGALLFGRL--KRRLGKRRLLAIGFALM--ALGFLLLALASGLWVVLLGAILAGLGF 300
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975949 253 GSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLI 324
Cdd:cd17473 301 GLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
3-325 |
3.50e-12 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 67.05 E-value: 3.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 3 LASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLIL 82
Cdd:cd17314 84 YLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTIL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 83 GSLLLNACVAGSLMRPlgpnqttsksknktgKTEDDSSPKKIKTKKSTWEKVnkyldfSLFKHRGFLIYLSGNVIMFLGF 162
Cdd:cd17314 164 GILAAIVLSVVSLLGF---------------KEPPDNQARLHVQKKKTQTMG------EIFRDKVFWILFIAIFLVLIGG 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 163 FAPIIFLAPYAKDQGIDEYS-AAFLLSVMAFVDMFARPSVGLIANsKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSL 241
Cdd:cd17314 223 FLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVAD-FFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGL 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 242 VLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW 321
Cdd:cd17314 302 VLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAI 381
|
....
gi 767975949 322 LLIG 325
Cdd:cd17314 382 LLAV 385
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
2-320 |
9.17e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 9.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 2 VLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYF-YRKRP-------MANGLAMAGSPVFLSSLApfnqylfnTF 73
Cdd:cd17474 79 LLCGLSDSFALL-LAGRALQGIGAAGLGPLALTLIGDLFeGGERAkamglyeAALGLGIAVGPLLGGLLA--------AI 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 74 GWKGSFLILGSLLLNACVAGSLMrplgpnqttsksKNKTGKTEDDSSPKKIKTKKStwekvnkyldfsLFKHRGFLIYLS 153
Cdd:cd17474 150 SWRYPFFLLAALIPVAFLAILFL------------LPEPKEKAKSSSATKLRDLKK------------ALRGRGLLTFLV 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 154 GNVIMFLGFFAPIIFLAPYAKD-QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIqYFFSFAIMfnGVCHLLC 232
Cdd:cd17474 206 SAFLYFFLYFAFLTYLPFLLELlYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRI-LVIGLLLY--ALSLLLL 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 233 PLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCG 312
Cdd:cd17474 283 GFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGA 361
|
....*...
gi 767975949 313 AIVVAASV 320
Cdd:cd17474 362 AIALAAAV 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
152-320 |
1.33e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 62.23 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 152 LSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLL 231
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLD--RFGRKRLLLIGLLIF--ALATLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 232 CPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSC 311
Cdd:cd17489 78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVA 156
|
....*....
gi 767975949 312 GAIVVAASV 320
Cdd:cd17489 157 AVLALLALL 165
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
157-365 |
1.34e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 62.21 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 157 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqYFFSFAIMfnGVCHLLCPLAQ 236
Cdd:cd17325 7 LDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD-RFGRKRL-LLLGLLLL--AVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 237 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVV 316
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALAL 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 767975949 317 AASVWLLignainyRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKV 365
Cdd:cd17325 162 LALVLAL-------LLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLA 203
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
6-323 |
5.11e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 60.30 E-value: 5.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 6 FSSSVVQLYLTMgFITGLGLAFNLQPALTIIGKYFYRKRpMANGLAMAGSPVFLSSL--APFNQYLFNTFGWKGSFLILG 83
Cdd:cd17489 80 LATSVALLLVLR-LIHGIGWGAFTTAAATLVADIIPPSR-RGEGIGYYGLATTLAMAlgPALGLFLYQHLGFAVLFIVAA 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 84 SLLLNACVAGSLMrplgpnqttsksknktgkteddsspKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNViMFLGFF 163
Cdd:cd17489 158 VLALLALLLVFLV-------------------------KDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFL-ASIAYG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 164 APIIFLAPYAKDQGIDEysAAFLLSVMAFVDMFARPSVGLIANskyiRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVL 243
Cdd:cd17489 212 AISTFLPLYAAERGISN--AGLFFTVYAIALLLSRPFSGKLSD----RKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 244 YAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLL 323
Cdd:cd17489 286 AAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
1-323 |
4.93e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.25 E-value: 4.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMgFITGLGLAfNLQPALT--IIGKYFYRKRPMANGLAMAGSPV--FLSSLA-PfnqYLFNTFGW 75
Cdd:cd17475 75 ALLMALVGSYPVLLVLL-FLVGAGYG-SVQPGGGraIMRWFPPRERGLAMGIRQTGVPLggALAAALlP---PLALHYGW 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 76 KGSFLILGSLLLNACVAGSLM--RPLGPNQTTSKsknktgkteddsspkkiktKKSTWEKVNKYLDFSLFKhrgfLIYLS 153
Cdd:cd17475 150 RAAFVVAGLVSILAAVLFWLFyrEPPAASAATES-------------------ASTLLRSLKEVLRNRDVW----LIAIA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 154 GnVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLC 232
Cdd:cd17475 207 G-ALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLS 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 233 PLAQDYTSLVLYAVFFGLGFGSVS--SVLFETLMDLVGAPRFSSAVGL-VTIVECGpVLLGPPLAGKLVDLTGEYKYMYM 309
Cdd:cd17475 286 LLSPGTPLWLLVLLLILLGLFAIGwnGLYLTLVAESAGPEQAGTALGLaNTINFIG-IAIGPPLFGLLVDATHSYAPAWL 364
|
330
....*....|....
gi 767975949 310 SCGAIVVAASVWLL 323
Cdd:cd17475 365 ALALLLVLAALLLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
157-323 |
2.47e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 55.25 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 157 IMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAImfngVCHLLCPLAQ 236
Cdd:cd17324 10 AIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI----LGNLLAALAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 237 DYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVV 316
Cdd:cd17324 86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAIAVLAL 164
|
....*..
gi 767975949 317 AASVWLL 323
Cdd:cd17324 165 LAALLLW 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
141-343 |
4.88e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 4.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 141 SLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIAnsKYIRPRIQYFFS 219
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFGKKKAFIIG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 220 FAIMfnGVCHLLCPLAQ--DYTSLVLYAVFFGLGFGSVSSVLFETLMDLV-------GAPRFSSAVGLVTIVECGPVLLG 290
Cdd:COG2211 301 LLLA--ALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFGIFTFAIKLGQALA 378
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767975949 291 PPLAGKLVDLTG-------------EYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENAR 343
Cdd:COG2211 379 GALAGLLLALFGyvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
152-324 |
1.05e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.19 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 152 LSGNVIMFLGFFAPIIFLAPY-AKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIanSKYIRPRIQYFFSFAIMfnGVCHL 230
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL--SDRFGRRRVLLIGLLLF--ALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 231 LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMS 310
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLI 156
|
170
....*....|....
gi 767975949 311 CGAIVVAASVWLLI 324
Cdd:pfam07690 157 LAILSLLAAVLLLL 170
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
148-324 |
3.21e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 51.97 E-value: 3.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 148 FLIYL-SGNVIMFLGFFAPIIflapyAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqyfFSFAIMFNG 226
Cdd:TIGR00895 23 FLIMLmDGYDLAAMGFAAPAI-----SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLAD-RIGRRRV---LLWSILLFS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 227 VCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKY 306
Cdd:TIGR00895 94 VFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG-WRS 172
|
170
....*....|....*...
gi 767975949 307 MYMsCGAIVVAASVWLLI 324
Cdd:TIGR00895 173 LFY-VGGIAPLLLLLLLM 189
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
154-328 |
3.36e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.79 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 154 GNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIqyFFSFAIMFNGVCHLLCP 233
Cdd:COG2271 18 AYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD--RFGRRR--VLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 234 LAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIveCGPV--LLGPPLAGKLVDLTGeYKYMYMSC 311
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNA--GGPLggALAPPLLGWLLAAFG-WRAAFLIL 170
|
170
....*....|....*..
gi 767975949 312 GAIVVAASVWLLIGNAI 328
Cdd:COG2271 171 GLPGLLLALLRFWLLAL 187
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
2-323 |
3.37e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.78 E-value: 3.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 2 VLASFSSSVVQLyLTMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17324 79 LLAALAPSFALL-LLARALAGLAHGGFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGslLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEddsspkkiktkkstwekvnkyldFSLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17324 158 AIA--VLALLAALLLWRLLPSLPPKKPGSLGLLSSL-----------------------LLLLRNPRLRLAYLITFLLFG 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIqYFFSFAIMFNGVchLLCPLAQDYT 239
Cdd:cd17324 213 GFFALYTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD-RGGRRAL-LIALLLLAAALL--LLTLLGPSPL 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 240 SLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRfSSAVGL-VTIVECGpVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAA 318
Cdd:cd17324 289 LLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLyLAAYNLG-GALGAALGGLVLDHGG-WAGVGWVGAALLLLA 365
|
....*
gi 767975949 319 SVWLL 323
Cdd:cd17324 366 LLLAL 370
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
160-320 |
1.12e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 46.91 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 160 LGFFAPIIFLAPYAKDQGIDEYSAAFLlsvMAFVDMFARPSVGLianSKYIRPRIQYFFSFAIMF--NGVCHLLCPLAQD 237
Cdd:cd06180 210 FGYIITATFLPLIARETGAGSLLAGLL---WSLFGLAAVPSCFL---WGALSDRWGTRRALAANLlvQAVGVLLPLLSPG 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 238 YTSLVLYAVFFGLGF-GSVSSVLFETLMdlVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVV 316
Cdd:cd06180 284 PAGLVLSAVLFGGTFmAITALVMALARE--LAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALV 361
|
....
gi 767975949 317 AASV 320
Cdd:cd06180 362 VAAL 365
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
154-327 |
3.95e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 154 GNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLLCP 233
Cdd:COG2223 13 AFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD--RFGPRRVLLIGLLLL--GIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 234 LAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTG-EYKYMYMSCG 312
Cdd:COG2223 89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGwRNAFLILGIL 168
|
170
....*....|....*
gi 767975949 313 AIVVAASVWLLIGNA 327
Cdd:COG2223 169 LLVVAVLAWLFLRDP 183
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
146-280 |
1.47e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 43.32 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 146 RGFLIYLSGNVIMFLGFFAPIIFLAPYAKD-QGIDEYSAAFLLSVMAFVDMFARPSVGLIANSkyIRPRIQYFFSFAIMF 224
Cdd:cd17321 168 RTFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADR--FGPRLVLVAGLLLTA 245
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 767975949 225 NGVCHL-LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVT 280
Cdd:cd17321 246 VGLLLLaLLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILN 302
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
123-324 |
2.58e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 2.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 123 KIKTKKSTWEKVNKYLD--FSLFKHRgFLIYLS--GNVIMFLGFFAPIIFLAPYAKDQGideySAAFLLSVMAFVDMFAR 198
Cdd:cd17490 169 FIKEERREKKPVLTELKelLSVLKDK-KLLFFSllAILQQMITFSTTFGFTPLIAKQLG----ASSFQLGLLSIIYLLPN 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 199 PSVGLIANSKYIRPRIQY---FFSFAIMfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSA 275
Cdd:cd17490 244 ALASLLSGTLFYKKLGERntiIIGFLLL--GAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTA 321
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 767975949 276 VGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWLLI 324
Cdd:cd17490 322 MGFFQAIYALGMFLGPVLVGIISEAFG-LQTGFFVIGVIALLAAILSLA 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
151-324 |
3.34e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.41 E-value: 3.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 151 YLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRiqYFFSFAIMFNGVCHL 230
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD--RFGRR--PVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 231 LCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVD-LTGEYKYMYM 309
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASsLGFGWRAVFL 156
|
170
....*....|....*
gi 767975949 310 SCGAIVVAASVWLLI 324
Cdd:cd06174 157 IAAALALLAAILLLL 171
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
1-96 |
3.65e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.19 E-value: 3.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPV------FLSSLapfnqyLFNTF 73
Cdd:cd17365 78 TLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAITLVSEYApARRRSLAVTLMFCGYPLgaalggFLAAA------LIPAF 150
|
90 100
....*....|....*....|....*
gi 767975949 74 GWKGSFLILGS--LLLNACVAGSLM 96
Cdd:cd17365 151 GWRSVFLLGGVppLILLPLLRGTLL 175
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
2-324 |
4.31e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 2 VLASFSSSVVQLYLtMGFITGLGLAFNLQPALTIIGKYF-YRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFL 80
Cdd:cd17319 83 ALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 81 ILGslllnacVAGSLMRPLgpnqttsksknktgkteddsspkkiktkkstWekvnkyldfsLFKHRGFLIYLSGNVIMFL 160
Cdd:cd17319 162 IEG-------LLGLLLAVL-------------------------------W----------WFYLRQVWGLALGYFGINY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS 240
Cdd:cd17319 194 ALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 241 LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASV 320
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
....
gi 767975949 321 WLLI 324
Cdd:cd17319 354 LVLL 357
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
149-325 |
5.54e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 5.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 149 LIYLSGNVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIA---NSKYIRpRIQYFFSFAIMF 224
Cdd:COG2211 13 LAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSdrtRTRWGR-RRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 225 nGVCHLLCPLA--QDYTSLVLYAVFFGLGFG---SVSSVLFETLM-DLVGAPR-------FSSAVGLVTIvecgpvLLGP 291
Cdd:COG2211 92 -ALSFVLLFTApdLSPTGKLIYALVTYLLLGlayTLVNIPYSALGaELTPDYEertrlssWRFAFAGLGG------LLAS 164
|
170 180 190
....*....|....*....|....*....|....*....
gi 767975949 292 PLAGKLVDLTGE-----YKYMYMSCGAIVVAASVWLLIG 325
Cdd:COG2211 165 VLPPPLVAAFGGdaalgYRLTALIFAVLGLLAFLLTFFG 203
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
138-282 |
9.78e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.02 E-value: 9.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 138 LDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAkdQGIDEYSA---AFLLSVMAFVDMFARPSVGLIanSKYIRPRI 214
Cdd:cd17503 170 LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYL--QNVLGYSAfesGLVLAPGGLASAILSPLVGRL--LDKFGPRL 245
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 215 QYFFSFAIMFnGVCHLLCPL--AQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIV 282
Cdd:cd17503 246 LLLAGLLLLA-LGTLLLAFLtpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTI 314
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-322 |
9.89e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 9.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVqLYLTMGFITGLGLAF---NLQPALTIIGKYFYRKR-PMA---NGLAMAGSPVFLSSLAPFNqylfNTF 73
Cdd:COG0738 87 LLLFALAPSYP-LLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLhafFSLGALLGPLLGGLLILLG----LSL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 74 GWKGSFLILGSLLLNACVAgslmrplgpnqtTSKSKNKTGKTEDDSSPKKIKTKKStwekvnkyldfsLFKHRGFLIYLs 153
Cdd:COG0738 162 SWHLPYLILAVLLLLLALL------------FLRSKLPEIEEEEEEAAGSAASLKS------------LLKNPRLLLGG- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 154 gnVIMFLGFFA---PIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIAnsKYIRPRIQYFFSFAIMFNGVch 229
Cdd:COG0738 217 --LAIFLYVGAegaIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLL--KRFGPVRLLRLSALLAAVGL-- 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 230 LLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRfSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYM 309
Cdd:COG0738 291 LLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369
|
330
....*....|....*
gi 767975949 310 S--CGAIVVAASVWL 322
Cdd:COG0738 370 PlvCYLLILLLALAL 384
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
161-321 |
1.41e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 161 GFF--APIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANsKYIRPRIQYFFSFAIMfngVCHLLCPLAqDY 238
Cdd:cd17477 201 GFLegAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLAD-RFDRRRVLLGCALLGA---LAALLLPLV-PG 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 239 TSLVLYAVFF--GLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVV 316
Cdd:cd17477 276 LPLALLVLLFlwGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
....*
gi 767975949 317 AASVW 321
Cdd:cd17477 356 FLLFL 360
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
1-255 |
1.44e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 40.31 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 1 MVLASFSSSVVQLYLTMGFITGLGLAfNLQPALTIIGKYFYRKRP-----MANGLAMAGSPV---FLSSLAPFNQYLFNT 72
Cdd:cd17341 78 LLALALAVSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIggaagGIAGAGNMGVAVsqlLAPLIAGAIVFDGGF 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 73 FGWKGSFLILGSLLLnacVAGSLMRPLGPNQTTSKSKNKTGKTEddssPKKIKTKKSTWEkvnkyldFSLFkhrgfliYl 152
Cdd:cd17341 157 VGWRNAFFVPGILLA---IAAVLVLLFGDDLPTGKASALEFLKV----QLAVLKNYRTWI-------LSLL-------Y- 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 153 sgnVIMFLGFFAPIIFLAPYAKDQ-GIDEYSAAFLLSVMAFVDMFARPSVGLIANskYIRPRIQYFFSFAIMfnGVCHLL 231
Cdd:cd17341 215 ---GVTFGSFVGFSNVLPTYFKTRfGLPLVTAGILAALFPLAGALARPAGGWLSD--RFGGRRRLWWLFIVM--TIGAAL 287
|
250 260 270
....*....|....*....|....*....|...
gi 767975949 232 C---------PLAQDYTSLVLYAVFFGLGFGSV 255
Cdd:cd17341 288 LslslptsgtNLVLFLALFVALGLGAGAGNGSV 320
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
163-323 |
2.80e-03 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 39.52 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 163 FAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKyirPRIQYFFSFAIMFNGVChLLCPLAQDYTSLV 242
Cdd:PRK10213 37 FLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQAT---DRRYVVILFAVLLTLSC-LLVSFANSFSLLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 243 LYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGeYKYMYMSCGAIVVAASVWL 322
Cdd:PRK10213 113 IGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIG-WRNVFNAAAVMGVLCIFWI 191
|
.
gi 767975949 323 L 323
Cdd:PRK10213 192 I 192
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
141-324 |
4.32e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 141 SLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSA-AFLLSVMAFVDMFARPSVGLIANSKYIRPRIqyffS 219
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLlGLLLALNALLIVLLQFPVARLVERFRLRKIL----M 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 220 FAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLG---FGSVSSVLFETLMDLVGAPRFSSAVGLVTIVEcgpVLLGPPLAGK 296
Cdd:cd17329 271 IGILLFAIGFAVLAFANTLAVLILAMIVLTLGemlVFPAVQTLVAALAPPDKRGSYMGFYALAWGLG---RAIGPLVGGL 347
|
170 180
....*....|....*....|....*...
gi 767975949 297 LVDLTGeYKYMYMSCGAIVVAASVWLLI 324
Cdd:cd17329 348 LLDLLG-PGLPWLILAALGLIAAALLLG 374
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
148-331 |
4.32e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.72 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 148 FLIYLSgnvimfLGFFAPiiFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIAnSKYIRPRIQYFFSFAIMFNGV 227
Cdd:cd17335 7 FFFFAA------LGSLLP--FLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALA-DRFGKRKALLLLSLLAAVLFF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 228 CHLLCPLAQDYTSL---VLYAVFFGLGFGSVSSVLFETL---MDLVGAPRFSSAVGLVtivecgpvlLGPPLAGKLVDLT 301
Cdd:cd17335 78 LSLFFVAQIFWLLLllvILGAFFSAPVVPLVDSITLQYLgeeRERYGKQRLWGSIGFG---------IAALLVGILIDRS 148
|
170 180 190
....*....|....*....|....*....|
gi 767975949 302 GEYKYMYMSCGAIVVAASVWLLIGNAINYR 331
Cdd:cd17335 149 STYKNYTIAFYVFAVLMLLALLLALKFPFR 178
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
146-302 |
8.80e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 37.48 E-value: 8.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 146 RGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMafvdMFARPSVGLIANS---KYIRPRIqYFFSFAI 222
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAY----LLGRAIGLLLFGRlgdRYGRKRV-LLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 223 MfnGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTG 302
Cdd:COG0477 89 F--GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
116-267 |
9.89e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 37.97 E-value: 9.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975949 116 EDDSSPKKIKTKKSTWEKVnkyldFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDM 195
Cdd:cd17332 196 ERVVPPEEEKSKLPLLKSL-----KALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGAL 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767975949 196 FArpSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLV 267
Cdd:cd17332 271 LA--LLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVI 340
|
|
| |
