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Conserved domains on  [gi|767905102|ref|XP_011540068|]
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nucleoporin NDC1 isoform X1 [Homo sapiens]

Protein Classification

nucleoporin NDC1( domain architecture ID 10560087)

nucleoporin NDC1 is a component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope

Gene Ontology:  GO:0017056

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ndc1_Nup pfam09531
Nucleoporin protein Ndc1-Nup; Ndc1 is a nucleoporin protein that is a component of the Nuclear ...
18-666 8.36e-101

Nucleoporin protein Ndc1-Nup; Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.


:

Pssm-ID: 462824  Cd Length: 522  Bit Score: 318.12  E-value: 8.36e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102   18 PVLGWRIVASiVWSVLFLPICTTVFIIFsridlfhpiqWLSDSFSDLYSSYVIFYFLLLSVVIIIISIFNVEFYAVVPSI 97
Cdd:pfam09531   1 PVLHRRFVHA-ALLLLLLSYLVSLLLSS----------WFSLLWSWFPLGPAGFRALLLFLSLLPILVLRKAQLHVGPRT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102   98 PCSRLALIGKIIHPQQLMHSFIHAAMGmvmAWCAAVITQGQYSFLvvpcTGTNSF-GSPAAQTCLNEYHLFFLLTGAFMG 176
Cdd:pfam09531  70 TSSRFATLRASLFSLQTLETLLWYVVS---ALLFTEVYIWSLPSD----ANLGWItKESYERPRLNERPLYLLLSGLFLG 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  177 YSYSLLYFVNNMNYLPF----PIIQQYKFLRFRRSLLllVKHSCVESLFLVRNFCILYYFLgyiPKAWISTA------MN 246
Cdd:pfam09531 143 LVYSVLHLYFDRDRLDFkygfPIVPPSKYLFRRLPSI--LKKSLILSLISTLVSPIVYYLF---LRSFIWSTalsrpfLN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  247 LHIDEQVHrPLDTVSGllNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQP--PFAEGSDECLPKVLNSNPPp 324
Cdd:pfam09531 218 LPRSNAPP-PLDSLPF--NLSLLLRTWLLGFLLLLLWELANLLFDIYLTEGPLKKGKPisSESKDPNGTLLSGLKSKKP- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  325 IIKYLALQDLMLLSQYSPSRRQEVFSLSQPGGHPhNWTAISRECLNLLNGMTQKLIlyqeaaatngrvsssypvepkkln 404
Cdd:pfam09531 294 FVKLFAFQELAYIAQSFPDRRKAIFSDIDRKGGP-NWSQILDECLSVIKELTTRIN------------------------ 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  405 speetAFQTPKSsqmprpsvpplvktslfssklstpdvvspfgtpfgssvmnrmagifdvntcygSPQSPQLIRRGPRLW 484
Cdd:pfam09531 349 -----AKSPGQS-----------------------------------------------------PSPPARLSPRARKLL 370
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  485 TSASDQQMTEfsnpspstsisaegktmrqpsviyswiqnkrEQIKNFLSKrvLIMYFFSKHPEASIQAVFSDAQMHIWAL 564
Cdd:pfam09531 371 ETASDRLLSP-------------------------------EQQQALLSP--LIGYLFRQTLRRRLEALVANPQLIINAI 417
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  565 EGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY---FKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAI 641
Cdd:pfam09531 418 EALSNLLVASLTEDQYGVVQRDVPEILRTLTRLIEALDKFkdqLPAHWTDVEGPAQSSAREVPSLLDEVDALLDALKTGL 497
                         650       660
                  ....*....|....*....|....*
gi 767905102  642 YRITTTFGEHLNAVQASAEHQKRLQ 666
Cdd:pfam09531 498 YRIVTAFGPYLNDLGLSPEDLRLAK 522
 
Name Accession Description Interval E-value
Ndc1_Nup pfam09531
Nucleoporin protein Ndc1-Nup; Ndc1 is a nucleoporin protein that is a component of the Nuclear ...
18-666 8.36e-101

Nucleoporin protein Ndc1-Nup; Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.


Pssm-ID: 462824  Cd Length: 522  Bit Score: 318.12  E-value: 8.36e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102   18 PVLGWRIVASiVWSVLFLPICTTVFIIFsridlfhpiqWLSDSFSDLYSSYVIFYFLLLSVVIIIISIFNVEFYAVVPSI 97
Cdd:pfam09531   1 PVLHRRFVHA-ALLLLLLSYLVSLLLSS----------WFSLLWSWFPLGPAGFRALLLFLSLLPILVLRKAQLHVGPRT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102   98 PCSRLALIGKIIHPQQLMHSFIHAAMGmvmAWCAAVITQGQYSFLvvpcTGTNSF-GSPAAQTCLNEYHLFFLLTGAFMG 176
Cdd:pfam09531  70 TSSRFATLRASLFSLQTLETLLWYVVS---ALLFTEVYIWSLPSD----ANLGWItKESYERPRLNERPLYLLLSGLFLG 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  177 YSYSLLYFVNNMNYLPF----PIIQQYKFLRFRRSLLllVKHSCVESLFLVRNFCILYYFLgyiPKAWISTA------MN 246
Cdd:pfam09531 143 LVYSVLHLYFDRDRLDFkygfPIVPPSKYLFRRLPSI--LKKSLILSLISTLVSPIVYYLF---LRSFIWSTalsrpfLN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  247 LHIDEQVHrPLDTVSGllNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQP--PFAEGSDECLPKVLNSNPPp 324
Cdd:pfam09531 218 LPRSNAPP-PLDSLPF--NLSLLLRTWLLGFLLLLLWELANLLFDIYLTEGPLKKGKPisSESKDPNGTLLSGLKSKKP- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  325 IIKYLALQDLMLLSQYSPSRRQEVFSLSQPGGHPhNWTAISRECLNLLNGMTQKLIlyqeaaatngrvsssypvepkkln 404
Cdd:pfam09531 294 FVKLFAFQELAYIAQSFPDRRKAIFSDIDRKGGP-NWSQILDECLSVIKELTTRIN------------------------ 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  405 speetAFQTPKSsqmprpsvpplvktslfssklstpdvvspfgtpfgssvmnrmagifdvntcygSPQSPQLIRRGPRLW 484
Cdd:pfam09531 349 -----AKSPGQS-----------------------------------------------------PSPPARLSPRARKLL 370
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  485 TSASDQQMTEfsnpspstsisaegktmrqpsviyswiqnkrEQIKNFLSKrvLIMYFFSKHPEASIQAVFSDAQMHIWAL 564
Cdd:pfam09531 371 ETASDRLLSP-------------------------------EQQQALLSP--LIGYLFRQTLRRRLEALVANPQLIINAI 417
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  565 EGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY---FKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAI 641
Cdd:pfam09531 418 EALSNLLVASLTEDQYGVVQRDVPEILRTLTRLIEALDKFkdqLPAHWTDVEGPAQSSAREVPSLLDEVDALLDALKTGL 497
                         650       660
                  ....*....|....*....|....*
gi 767905102  642 YRITTTFGEHLNAVQASAEHQKRLQ 666
Cdd:pfam09531 498 YRIVTAFGPYLNDLGLSPEDLRLAK 522
 
Name Accession Description Interval E-value
Ndc1_Nup pfam09531
Nucleoporin protein Ndc1-Nup; Ndc1 is a nucleoporin protein that is a component of the Nuclear ...
18-666 8.36e-101

Nucleoporin protein Ndc1-Nup; Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.


Pssm-ID: 462824  Cd Length: 522  Bit Score: 318.12  E-value: 8.36e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102   18 PVLGWRIVASiVWSVLFLPICTTVFIIFsridlfhpiqWLSDSFSDLYSSYVIFYFLLLSVVIIIISIFNVEFYAVVPSI 97
Cdd:pfam09531   1 PVLHRRFVHA-ALLLLLLSYLVSLLLSS----------WFSLLWSWFPLGPAGFRALLLFLSLLPILVLRKAQLHVGPRT 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102   98 PCSRLALIGKIIHPQQLMHSFIHAAMGmvmAWCAAVITQGQYSFLvvpcTGTNSF-GSPAAQTCLNEYHLFFLLTGAFMG 176
Cdd:pfam09531  70 TSSRFATLRASLFSLQTLETLLWYVVS---ALLFTEVYIWSLPSD----ANLGWItKESYERPRLNERPLYLLLSGLFLG 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  177 YSYSLLYFVNNMNYLPF----PIIQQYKFLRFRRSLLllVKHSCVESLFLVRNFCILYYFLgyiPKAWISTA------MN 246
Cdd:pfam09531 143 LVYSVLHLYFDRDRLDFkygfPIVPPSKYLFRRLPSI--LKKSLILSLISTLVSPIVYYLF---LRSFIWSTalsrpfLN 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  247 LHIDEQVHrPLDTVSGllNLSLLYHVWLCGVFLLTTWYVSWILFKIYATEAHVFPVQP--PFAEGSDECLPKVLNSNPPp 324
Cdd:pfam09531 218 LPRSNAPP-PLDSLPF--NLSLLLRTWLLGFLLLLLWELANLLFDIYLTEGPLKKGKPisSESKDPNGTLLSGLKSKKP- 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  325 IIKYLALQDLMLLSQYSPSRRQEVFSLSQPGGHPhNWTAISRECLNLLNGMTQKLIlyqeaaatngrvsssypvepkkln 404
Cdd:pfam09531 294 FVKLFAFQELAYIAQSFPDRRKAIFSDIDRKGGP-NWSQILDECLSVIKELTTRIN------------------------ 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  405 speetAFQTPKSsqmprpsvpplvktslfssklstpdvvspfgtpfgssvmnrmagifdvntcygSPQSPQLIRRGPRLW 484
Cdd:pfam09531 349 -----AKSPGQS-----------------------------------------------------PSPPARLSPRARKLL 370
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  485 TSASDQQMTEfsnpspstsisaegktmrqpsviyswiqnkrEQIKNFLSKrvLIMYFFSKHPEASIQAVFSDAQMHIWAL 564
Cdd:pfam09531 371 ETASDRLLSP-------------------------------EQQQALLSP--LIGYLFRQTLRRRLEALVANPQLIINAI 417
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767905102  565 EGLSHLVAASFTEDRFGVVQTTLPAILNTLLTLQEAVDKY---FKLPHASSKPPRISGSLVDTSYKTLRFAFRASLKTAI 641
Cdd:pfam09531 418 EALSNLLVASLTEDQYGVVQRDVPEILRTLTRLIEALDKFkdqLPAHWTDVEGPAQSSAREVPSLLDEVDALLDALKTGL 497
                         650       660
                  ....*....|....*....|....*
gi 767905102  642 YRITTTFGEHLNAVQASAEHQKRLQ 666
Cdd:pfam09531 498 YRIVTAFGPYLNDLGLSPEDLRLAK 522
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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