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Conserved domains on  [gi|767969522|ref|XP_011540873|]
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beta-galactosidase-1-like protein 3 isoform X8 [Homo sapiens]

Protein Classification

glycoside hydrolase family 35 protein( domain architecture ID 10472897)

glycoside hydrolase family 35 protein similar to Xanthomonas phaseoli beta-galactosidase that catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

CAZY:  GH35
EC:  3.2.1.-
Gene Ontology:  GO:0004565|GO:0005975
SCOP:  4003303

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
127-435 6.46e-144

Glycosyl hydrolases family 35;


:

Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 417.04  E-value: 6.46e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  127 FTLEGHKFLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVIL 206
Cdd:pfam01301   2 FLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  207 RPGRYICSEMDLGGLPSWLLQDPRLLLRTTNKSFIEAVEKYFDHLIPRVIPLQYRQAGPVIAVQVENEYGSFNKDKTYMP 286
Cdd:pfam01301  82 RPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYLR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  287 YLHKALLRRGIVE-LLLTSDG-EKHVLSGHTKG---VLAAINLQkLHQD---TFNQLHKVQRDKPLLIMEYWVGWFDRWG 358
Cdd:pfam01301 162 ALRKAYKEWGADMaLLFTTDGpWGMCLQCGDLPgpdIYATNGFG-CGANppsNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767969522  359 DKHHVKDAKEVEHAVSEFIKYEISFNVYMFHGGTNFGFMNGATYFGkhsGIVTSYDYDAVLTEAGDYTEKYLKLQKL 435
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG---PQTTSYDYDAPIDEAGDPTPKYGHLKDL 314
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
127-435 6.46e-144

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 417.04  E-value: 6.46e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  127 FTLEGHKFLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVIL 206
Cdd:pfam01301   2 FLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  207 RPGRYICSEMDLGGLPSWLLQDPRLLLRTTNKSFIEAVEKYFDHLIPRVIPLQYRQAGPVIAVQVENEYGSFNKDKTYMP 286
Cdd:pfam01301  82 RPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYLR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  287 YLHKALLRRGIVE-LLLTSDG-EKHVLSGHTKG---VLAAINLQkLHQD---TFNQLHKVQRDKPLLIMEYWVGWFDRWG 358
Cdd:pfam01301 162 ALRKAYKEWGADMaLLFTTDGpWGMCLQCGDLPgpdIYATNGFG-CGANppsNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767969522  359 DKHHVKDAKEVEHAVSEFIKYEISFNVYMFHGGTNFGFMNGATYFGkhsGIVTSYDYDAVLTEAGDYTEKYLKLQKL 435
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG---PQTTSYDYDAPIDEAGDPTPKYGHLKDL 314
PLN03059 PLN03059
beta-galactosidase; Provisional
113-439 1.34e-47

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 177.50  E-value: 1.34e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 113 VGLGTESTGRGKPHFTLEGHKFLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTTYVPWNLHEPERGKFDFSGNLDLEA 192
Cdd:PLN03059  23 VSHGSASVSYDHRAFIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVK 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 193 FVLMAAEIGLWVILRPGRYICSEMDLGGLPSWLLQDPRLLLRTTNKSFIEAVEKYFDHLIP--RVIPLQYRQAGPVIAVQ 270
Cdd:PLN03059 103 FIKVVQAAGLYVHLRIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIVDmmKSEKLFEPQGGPIILSQ 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 271 VENEYGSFNKD-----KTYMPYLHKALLRRGIvellltsdGEKHVLSGHTKGVLAAInlqklhqDTFNQLH----KVQRD 341
Cdd:PLN03059 183 IENEYGPVEWEigapgKAYTKWAADMAVKLGT--------GVPWVMCKQEDAPDPVI-------DTCNGFYcenfKPNKD 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 342 -KPLLIMEYWVGWFDRWGDKHHVKDAKEVEHAVSEFIKYEISF-NVYMFHGGTNFGFMNGATYfgkhsgIVTSYDYDAVL 419
Cdd:PLN03059 248 yKPKMWTEAWTGWYTEFGGAVPNRPAEDLAFSVARFIQNGGSFiNYYMYHGGTNFGRTAGGPF------IATSYDYDAPL 321
                        330       340
                 ....*....|....*....|.
gi 767969522 420 TEAGDYTE-KYLKLQKLFQSV 439
Cdd:PLN03059 322 DEYGLPREpKWGHLRDLHKAI 342
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
134-482 5.50e-47

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 173.19  E-value: 5.50e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 134 FLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTT-YVPWNLHEPERGKFDFSGnldLEAFVLMAAEIGLWVILRPGRYI 212
Cdd:COG1874    9 FLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVILRTPTAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 213 csemdlggLPSWLLQDPRLLLRT-----------------TNKSFIEAVEKYFDHLIPRviplqYRQAGPVIAVQVENEY 275
Cdd:COG1874   86 --------PPAWLLKKYPEILPVdadgrrrgfgsrrhycpSSPVYREAARRIVRALAER-----YGDHPAVIMWQVDNEY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 276 GSFN-------------KDK------------------TY-------MPYLH---------------------------K 290
Cdd:COG1874  153 GSYDycdacaaafrdwlRERygtldalneawgtafwsqRYtdwdeiePPRLTpttanpslrldfrrfssdqvleylraqR 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 291 ALLRRGIVELLLTsdgekHVLSGHTK-----------GVLAAIN-LQKLHQDTFNQ-LHK-----VQRDKPLLIMEYWVG 352
Cdd:COG1874  233 DILREAGPDVPVT-----TNFMGPFPgldywklardlDVVSWDNyPDGSAADPDEIaFAHdlmrgLKGGGPFMVMEQWPG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 353 WFdRWGDKHHVKDAKEVEHAVSEFIKYEIS-FNVYMFHggtnfgfmngATYFGkhsgivTSYDYDAVLTEAGDYTEKYLK 431
Cdd:COG1874  308 WV-NWGPYNPAKRPGQLRLWSLQALAHGADgVNYFQWR----------PSRGG------TEYDHDAPLDHAGRPTRKFRE 370
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767969522 432 LQKLFQSVsaTPLPRVPKLPPKAvyppvRPSLylpLWDALSYLNEPVRSRQ 482
Cdd:COG1874  371 VRELGAEL--ARLPEVPGSRVTA-----RVAL---LFDWESWWALEIQSPP 411
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
127-435 6.46e-144

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 417.04  E-value: 6.46e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  127 FTLEGHKFLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVIL 206
Cdd:pfam01301   2 FLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  207 RPGRYICSEMDLGGLPSWLLQDPRLLLRTTNKSFIEAVEKYFDHLIPRVIPLQYRQAGPVIAVQVENEYGSFNKDKTYMP 286
Cdd:pfam01301  82 RPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYLR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  287 YLHKALLRRGIVE-LLLTSDG-EKHVLSGHTKG---VLAAINLQkLHQD---TFNQLHKVQRDKPLLIMEYWVGWFDRWG 358
Cdd:pfam01301 162 ALRKAYKEWGADMaLLFTTDGpWGMCLQCGDLPgpdIYATNGFG-CGANppsNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767969522  359 DKHHVKDAKEVEHAVSEFIKYEISFNVYMFHGGTNFGFMNGATYFGkhsGIVTSYDYDAVLTEAGDYTEKYLKLQKL 435
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANFYG---PQTTSYDYDAPIDEAGDPTPKYGHLKDL 314
PLN03059 PLN03059
beta-galactosidase; Provisional
113-439 1.34e-47

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 177.50  E-value: 1.34e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 113 VGLGTESTGRGKPHFTLEGHKFLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTTYVPWNLHEPERGKFDFSGNLDLEA 192
Cdd:PLN03059  23 VSHGSASVSYDHRAFIINGQRRILISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVK 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 193 FVLMAAEIGLWVILRPGRYICSEMDLGGLPSWLLQDPRLLLRTTNKSFIEAVEKYFDHLIP--RVIPLQYRQAGPVIAVQ 270
Cdd:PLN03059 103 FIKVVQAAGLYVHLRIGPYICAEWNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIVDmmKSEKLFEPQGGPIILSQ 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 271 VENEYGSFNKD-----KTYMPYLHKALLRRGIvellltsdGEKHVLSGHTKGVLAAInlqklhqDTFNQLH----KVQRD 341
Cdd:PLN03059 183 IENEYGPVEWEigapgKAYTKWAADMAVKLGT--------GVPWVMCKQEDAPDPVI-------DTCNGFYcenfKPNKD 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 342 -KPLLIMEYWVGWFDRWGDKHHVKDAKEVEHAVSEFIKYEISF-NVYMFHGGTNFGFMNGATYfgkhsgIVTSYDYDAVL 419
Cdd:PLN03059 248 yKPKMWTEAWTGWYTEFGGAVPNRPAEDLAFSVARFIQNGGSFiNYYMYHGGTNFGRTAGGPF------IATSYDYDAPL 321
                        330       340
                 ....*....|....*....|.
gi 767969522 420 TEAGDYTE-KYLKLQKLFQSV 439
Cdd:PLN03059 322 DEYGLPREpKWGHLRDLHKAI 342
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
134-482 5.50e-47

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 173.19  E-value: 5.50e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 134 FLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTT-YVPWNLHEPERGKFDFSGnldLEAFVLMAAEIGLWVILRPGRYI 212
Cdd:COG1874    9 FLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVILRTPTAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 213 csemdlggLPSWLLQDPRLLLRT-----------------TNKSFIEAVEKYFDHLIPRviplqYRQAGPVIAVQVENEY 275
Cdd:COG1874   86 --------PPAWLLKKYPEILPVdadgrrrgfgsrrhycpSSPVYREAARRIVRALAER-----YGDHPAVIMWQVDNEY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 276 GSFN-------------KDK------------------TY-------MPYLH---------------------------K 290
Cdd:COG1874  153 GSYDycdacaaafrdwlRERygtldalneawgtafwsqRYtdwdeiePPRLTpttanpslrldfrrfssdqvleylraqR 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 291 ALLRRGIVELLLTsdgekHVLSGHTK-----------GVLAAIN-LQKLHQDTFNQ-LHK-----VQRDKPLLIMEYWVG 352
Cdd:COG1874  233 DILREAGPDVPVT-----TNFMGPFPgldywklardlDVVSWDNyPDGSAADPDEIaFAHdlmrgLKGGGPFMVMEQWPG 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522 353 WFdRWGDKHHVKDAKEVEHAVSEFIKYEIS-FNVYMFHggtnfgfmngATYFGkhsgivTSYDYDAVLTEAGDYTEKYLK 431
Cdd:COG1874  308 WV-NWGPYNPAKRPGQLRLWSLQALAHGADgVNYFQWR----------PSRGG------TEYDHDAPLDHAGRPTRKFRE 370
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767969522 432 LQKLFQSVsaTPLPRVPKLPPKAvyppvRPSLylpLWDALSYLNEPVRSRQ 482
Cdd:COG1874  371 VRELGAEL--ARLPEVPGSRVTA-----RVAL---LFDWESWWALEIQSPP 411
Glyco_hydro_42 pfam02449
Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase ...
144-276 8.83e-11

Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.


Pssm-ID: 396834  Cd Length: 376  Bit Score: 63.83  E-value: 8.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969522  144 FRVPREYWRDRLLKLKACGFNTVT-TYVPWNLHEPERGKFDFSGnldLEAFVLMAAEIGLWVILRPGRyicsemdlGGLP 222
Cdd:pfam02449   5 EQWPEETWEEDIRLMKEAGVNVVRiGIFAWAKLEPEEGKYDFEW---LDEVIDLLAKAGIKVILATPT--------AAPP 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767969522  223 SWLLQD-PRLLLRT----------------TNKSFIEAVEKyfdhlIPRVIPLQYRQAGPVIAVQVENEYG 276
Cdd:pfam02449  74 AWLVKKhPEILPVDadgrrrgfgsrhhycpSSPVYREYAAR-----IVEALAERYGDHPALIGWHIDNEYG 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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