NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767970566|ref|XP_011541286|]
View 

coiled-coil domain-containing protein 82 isoform X1 [Homo sapiens]

Protein Classification

DUF4211 domain-containing protein( domain architecture ID 10620095)

DUF4211 domain-containing protein similar to Homo sapiens proline-rich protein 12 and Xenopus laevis glutamine and serine-rich protein 1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
DUF4196 pfam13846
Domain of unknown function (DUF4196); This is a short region of ccdc82_homologs that is ...
102-236 4.19e-45

Domain of unknown function (DUF4196); This is a short region of ccdc82_homologs that is conserved from Schizo. pombe up to humans. The function is not known.


:

Pssm-ID: 433523  Cd Length: 112  Bit Score: 154.59  E-value: 4.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  102 NSGNGSTYEEETNKIKHRNIDLQDQEKHLSQEDNDLNKQTGQIIEDDqekhlsqedndlnkqtgqiieddLEEEDIKRGK 181
Cdd:pfam13846   1 NTGNSSTYEEEKNKTKHRSIDLPDDEKHLSQEENDLNKHTGQIIEED-----------------------LEEEHIKRGK 57
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767970566  182 RKRLSSVMCDSDESDDSDILVRKVGVKRPRRVVEDEGSSVEMEQKTPEKTLAAQK 236
Cdd:pfam13846  58 RKRISSVMYDSDDSDDSDILVRKVGVKRPRRVVEDECSSVEMEQKNPEKTSAARK 112
DUF4211 pfam13926
Domain of unknown function (DUF4211);
297-449 5.32e-44

Domain of unknown function (DUF4211);


:

Pssm-ID: 464045  Cd Length: 138  Bit Score: 152.41  E-value: 5.32e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  297 DFVVQDEEGDEenknqqgeklTTSQLKLVKQNSLYSFSDHYTHFERVVKALLINALDESFLGTLYDgtrqkSYAKDMLTS 376
Cdd:pfam13926   1 DFIVEDDDDEL----------GVPDEELPLEFSRLSHQDLKEHFKVVVEWLVHNAIDPDFLRSLYD-----KDDEYYLVA 65
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767970566  377 LHYLDNRfVQPRLESLVSRSRWKEQYKERVENYSNVSIHLKNPENCSCQACGLHRY-CKYSVHLSGELYNTRTM 449
Cdd:pfam13926  66 LRKLDDE-VQGLADSLLSSSAWKPEFKKALEARPELRITELDPKDGGCDACNRSNHpATFTIRLSGKPYNKETL 138
 
Name Accession Description Interval E-value
DUF4196 pfam13846
Domain of unknown function (DUF4196); This is a short region of ccdc82_homologs that is ...
102-236 4.19e-45

Domain of unknown function (DUF4196); This is a short region of ccdc82_homologs that is conserved from Schizo. pombe up to humans. The function is not known.


Pssm-ID: 433523  Cd Length: 112  Bit Score: 154.59  E-value: 4.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  102 NSGNGSTYEEETNKIKHRNIDLQDQEKHLSQEDNDLNKQTGQIIEDDqekhlsqedndlnkqtgqiieddLEEEDIKRGK 181
Cdd:pfam13846   1 NTGNSSTYEEEKNKTKHRSIDLPDDEKHLSQEENDLNKHTGQIIEED-----------------------LEEEHIKRGK 57
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767970566  182 RKRLSSVMCDSDESDDSDILVRKVGVKRPRRVVEDEGSSVEMEQKTPEKTLAAQK 236
Cdd:pfam13846  58 RKRISSVMYDSDDSDDSDILVRKVGVKRPRRVVEDECSSVEMEQKNPEKTSAARK 112
DUF4211 pfam13926
Domain of unknown function (DUF4211);
297-449 5.32e-44

Domain of unknown function (DUF4211);


Pssm-ID: 464045  Cd Length: 138  Bit Score: 152.41  E-value: 5.32e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  297 DFVVQDEEGDEenknqqgeklTTSQLKLVKQNSLYSFSDHYTHFERVVKALLINALDESFLGTLYDgtrqkSYAKDMLTS 376
Cdd:pfam13926   1 DFIVEDDDDEL----------GVPDEELPLEFSRLSHQDLKEHFKVVVEWLVHNAIDPDFLRSLYD-----KDDEYYLVA 65
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767970566  377 LHYLDNRfVQPRLESLVSRSRWKEQYKERVENYSNVSIHLKNPENCSCQACGLHRY-CKYSVHLSGELYNTRTM 449
Cdd:pfam13926  66 LRKLDDE-VQGLADSLLSSSAWKPEFKKALEARPELRITELDPKDGGCDACNRSNHpATFTIRLSGKPYNKETL 138
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
39-175 3.88e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.28  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  39 DSDEELDSEEfDSDEELDSDESFENDEELDSNKGPDCNKTPGSERELNLSKIQSEGNDSKCLINSGNGSTYEEETNKIKH 118
Cdd:NF033609 705 DSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 783
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767970566 119 RNIDLQDQEKHLSQEDNDLNKQTGQIIEDDQEkhlSQEDNDLNKQTGQIIEDDLEEE 175
Cdd:NF033609 784 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSD 837
 
Name Accession Description Interval E-value
DUF4196 pfam13846
Domain of unknown function (DUF4196); This is a short region of ccdc82_homologs that is ...
102-236 4.19e-45

Domain of unknown function (DUF4196); This is a short region of ccdc82_homologs that is conserved from Schizo. pombe up to humans. The function is not known.


Pssm-ID: 433523  Cd Length: 112  Bit Score: 154.59  E-value: 4.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  102 NSGNGSTYEEETNKIKHRNIDLQDQEKHLSQEDNDLNKQTGQIIEDDqekhlsqedndlnkqtgqiieddLEEEDIKRGK 181
Cdd:pfam13846   1 NTGNSSTYEEEKNKTKHRSIDLPDDEKHLSQEENDLNKHTGQIIEED-----------------------LEEEHIKRGK 57
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767970566  182 RKRLSSVMCDSDESDDSDILVRKVGVKRPRRVVEDEGSSVEMEQKTPEKTLAAQK 236
Cdd:pfam13846  58 RKRISSVMYDSDDSDDSDILVRKVGVKRPRRVVEDECSSVEMEQKNPEKTSAARK 112
DUF4211 pfam13926
Domain of unknown function (DUF4211);
297-449 5.32e-44

Domain of unknown function (DUF4211);


Pssm-ID: 464045  Cd Length: 138  Bit Score: 152.41  E-value: 5.32e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  297 DFVVQDEEGDEenknqqgeklTTSQLKLVKQNSLYSFSDHYTHFERVVKALLINALDESFLGTLYDgtrqkSYAKDMLTS 376
Cdd:pfam13926   1 DFIVEDDDDEL----------GVPDEELPLEFSRLSHQDLKEHFKVVVEWLVHNAIDPDFLRSLYD-----KDDEYYLVA 65
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767970566  377 LHYLDNRfVQPRLESLVSRSRWKEQYKERVENYSNVSIHLKNPENCSCQACGLHRY-CKYSVHLSGELYNTRTM 449
Cdd:pfam13926  66 LRKLDDE-VQGLADSLLSSSAWKPEFKKALEARPELRITELDPKDGGCDACNRSNHpATFTIRLSGKPYNKETL 138
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
39-175 3.88e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 40.28  E-value: 3.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970566  39 DSDEELDSEEfDSDEELDSDESFENDEELDSNKGPDCNKTPGSERELNLSKIQSEGNDSKCLINSGNGSTYEEETNKIKH 118
Cdd:NF033609 705 DSDSDSDSDS-DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 783
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767970566 119 RNIDLQDQEKHLSQEDNDLNKQTGQIIEDDQEkhlSQEDNDLNKQTGQIIEDDLEEE 175
Cdd:NF033609 784 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD---SDSDSDSDSDSDSDSDSDSDSD 837
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH