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Conserved domains on  [gi|767970789|ref|XP_011541372|]
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etoposide-induced protein 2.4 homolog isoform X2 [Homo sapiens]

Protein Classification

EI24 domain-containing protein( domain architecture ID 10537971)

EI24 domain-containing protein such as bacterial CysZ family protein, which may function as a sulfate transporter, and mammalian etoposide-induced protein 2.4, a gene product induced by p53 in cells treated with the chemotherapy medication etoposide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EI24 pfam07264
Etoposide-induced protein 2.4 (EI24); This family contains a number of eukaryotic ...
 120-222 1.11e-03

Etoposide-induced protein 2.4 (EI24); This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.


:

Pssm-ID: 462129  Cd Length: 161  Bit Score: 38.70  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970789  120 FFLTSIFSALWVLPLFVLskVVNAIWFQDIADlafEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQgMFVSLFPIhlV 199
Cdd:pfam07264  26 LLLLLLLLPLFLFPAVAL--LIAAPFYGLLAE---KVEKHLTGKPVGLLRDLPDSLKKLLLFLLVLLV-LLPLLFPV--V 97

                          90       100
                  ....*....|....*....|....
gi 767970789  200 GQLVSLLHMSLLYS-LYCFEYRWF 222
Cdd:pfam07264  98 GQLLAPVLWFWLTArMLAFDYLDY 121
 
Name Accession Description Interval E-value
EI24 pfam07264
Etoposide-induced protein 2.4 (EI24); This family contains a number of eukaryotic ...
 120-222 1.11e-03

Etoposide-induced protein 2.4 (EI24); This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.


Pssm-ID: 462129  Cd Length: 161  Bit Score: 38.70  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970789  120 FFLTSIFSALWVLPLFVLskVVNAIWFQDIADlafEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQgMFVSLFPIhlV 199
Cdd:pfam07264  26 LLLLLLLLPLFLFPAVAL--LIAAPFYGLLAE---KVEKHLTGKPVGLLRDLPDSLKKLLLFLLVLLV-LLPLLFPV--V 97

                          90       100
                  ....*....|....*....|....
gi 767970789  200 GQLVSLLHMSLLYS-LYCFEYRWF 222
Cdd:pfam07264  98 GQLLAPVLWFWLTArMLAFDYLDY 121
 
Name Accession Description Interval E-value
EI24 pfam07264
Etoposide-induced protein 2.4 (EI24); This family contains a number of eukaryotic ...
 120-222 1.11e-03

Etoposide-induced protein 2.4 (EI24); This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53. It has been suggested to play an important role in negative cell growth control.


Pssm-ID: 462129  Cd Length: 161  Bit Score: 38.70  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767970789  120 FFLTSIFSALWVLPLFVLskVVNAIWFQDIADlafEVSGRKPHPFPSVSKIIADMLFNLLLQALFLIQgMFVSLFPIhlV 199
Cdd:pfam07264  26 LLLLLLLLPLFLFPAVAL--LIAAPFYGLLAE---KVEKHLTGKPVGLLRDLPDSLKKLLLFLLVLLV-LLPLLFPV--V 97

                          90       100
                  ....*....|....*....|....
gi 767970789  200 GQLVSLLHMSLLYS-LYCFEYRWF 222
Cdd:pfam07264  98 GQLLAPVLWFWLTArMLAFDYLDY 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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