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Conserved domains on  [gi|767935557|ref|XP_011541555|]
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spermatogenesis-associated protein 24 isoform X2 [Homo sapiens]

Protein Classification

SPATA24 domain-containing protein( domain architecture ID 12172058)

SPATA24 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPATA24 pfam15175
Spermatogenesis-associated protein 24; This family of proteins bind to DNA and to TBP (TATA ...
 1-123 2.16e-70

Spermatogenesis-associated protein 24; This family of proteins bind to DNA and to TBP (TATA box binding protein), TATA-binding protein (TBP)-related protein 2 (TRF2) and several polycomb factors. It is likely to function as a transcription regulator.


:

Pssm-ID: 464544 [Multi-domain]  Cd Length: 170  Bit Score: 217.79  E-value: 2.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557    1 MVLQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQESSK 80
Cdd:pfam15175  19 ARRQKENFVSKEEYEAVAKKLEEERAEHAKTKLLLAKESEKLQFALGEIEVLSKQLEREKKAFEKALGSVKSKALRESKK 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767935557   81 KDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIF 123
Cdd:pfam15175  99 ADQLKTKCSEIESHCIRQEDILNGKENEIKELKQRLSKQKEIH 141
 
Name Accession Description Interval E-value
SPATA24 pfam15175
Spermatogenesis-associated protein 24; This family of proteins bind to DNA and to TBP (TATA ...
 1-123 2.16e-70

Spermatogenesis-associated protein 24; This family of proteins bind to DNA and to TBP (TATA box binding protein), TATA-binding protein (TBP)-related protein 2 (TRF2) and several polycomb factors. It is likely to function as a transcription regulator.


Pssm-ID: 464544 [Multi-domain]  Cd Length: 170  Bit Score: 217.79  E-value: 2.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557    1 MVLQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQESSK 80
Cdd:pfam15175  19 ARRQKENFVSKEEYEAVAKKLEEERAEHAKTKLLLAKESEKLQFALGEIEVLSKQLEREKKAFEKALGSVKSKALRESKK 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767935557   81 KDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIF 123
Cdd:pfam15175  99 ADQLKTKCSEIESHCIRQEDILNGKENEIKELKQRLSKQKEIH 141
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 10-124 3.49e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.78  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   10 SKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQ---LEKEKLAFEKALSSVKSKVLQESSKKDQL-- 84
Cdd:TIGR04523 122 LEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQkeeLENELNLLEKEKLNIQKNIDKIKNKLLKLel 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767935557   85 --------ITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIFS 124
Cdd:TIGR04523 202 llsnlkkkIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEIS 249
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 12-121 4.41e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557  12 EEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKeklaFEKALSSVKS----KVLQ---ESSKKDQl 84
Cdd:COG1579   31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQLGNVRNnkeyEALQkeiESLKRRI- 105

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767935557  85 itkcNEIESHIIKQEDILNGKENEIKELQQVISQQKQ 121
Cdd:COG1579  106 ----SDLEDEILELMERIEELEEELAELEAELAELEA 138
PRK12704 PRK12704
phosphodiesterase; Provisional
 9-122 1.29e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   9 VSKEEFQAveKKLVEEkaahAKTKVLLAKEEEKLQfALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQES---SKKDQLI 85
Cdd:PRK12704  33 IKEAEEEA--KRILEE----AKKEAEAIKKEALLE-AKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEenlDRKLELL 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767935557  86 TKcneIESHIIKQEDILNGKENEIKELQQVIS--QQKQI 122
Cdd:PRK12704 106 EK---REEELEKKEKELEQKQQELEKKEEELEelIEEQL 141
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 3-122 8.49e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 37.69  E-value: 8.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557     3 LQDENFVSKEEFQaVEKKLVEEKAAHAKTkvLLAKEEEKLQFALGEVEVLSKQLEKeklaFEKALSSVKSKVLQESSKKD 82
Cdd:smart00787 177 LRDRKDALEEELR-QLKQLEDELEDCDPT--ELDRAKEKLKKLLQEIMIKVKKLEE----LEEELQELESKIEDLTNKKS 249

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767935557    83 QLITKCNEIEShiiKQEDILNGKENEIKELQQVISQQKQI 122
Cdd:smart00787 250 ELNTEIAEAEK---KLEQCRGFTFKEIEKLKEQLKLLQSL 286
 
Name Accession Description Interval E-value
SPATA24 pfam15175
Spermatogenesis-associated protein 24; This family of proteins bind to DNA and to TBP (TATA ...
 1-123 2.16e-70

Spermatogenesis-associated protein 24; This family of proteins bind to DNA and to TBP (TATA box binding protein), TATA-binding protein (TBP)-related protein 2 (TRF2) and several polycomb factors. It is likely to function as a transcription regulator.


Pssm-ID: 464544 [Multi-domain]  Cd Length: 170  Bit Score: 217.79  E-value: 2.16e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557    1 MVLQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQESSK 80
Cdd:pfam15175  19 ARRQKENFVSKEEYEAVAKKLEEERAEHAKTKLLLAKESEKLQFALGEIEVLSKQLEREKKAFEKALGSVKSKALRESKK 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767935557   81 KDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIF 123
Cdd:pfam15175  99 ADQLKTKCSEIESHCIRQEDILNGKENEIKELKQRLSKQKEIH 141
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 12-121 2.18e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.64  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   12 EEFQAVEKKLV-----EEKAAH-AKTKVLLAKEEEklQFALGEVEVLSKQLEKEKL------AFEKALSSVKSKVLQESS 79
Cdd:pfam05483 432 EELKGKEQELIfllqaREKEIHdLEIQLTAIKTSE--EHYLKEVEDLKTELEKEKLknieltAHCDKLLLENKELTQEAS 509

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767935557   80 kkDQLItkcnEIESHiikQEDILNGKENEIKELQQVISQQKQ 121
Cdd:pfam05483 510 --DMTL----ELKKH---QEDIINCKKQEERMLKQIENLEEK 542
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 10-124 3.49e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.78  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   10 SKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQ---LEKEKLAFEKALSSVKSKVLQESSKKDQL-- 84
Cdd:TIGR04523 122 LEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQkeeLENELNLLEKEKLNIQKNIDKIKNKLLKLel 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767935557   85 --------ITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIFS 124
Cdd:TIGR04523 202 llsnlkkkIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEIS 249
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 12-121 4.41e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.53  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557  12 EEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKeklaFEKALSSVKS----KVLQ---ESSKKDQl 84
Cdd:COG1579   31 AELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKK----YEEQLGNVRNnkeyEALQkeiESLKRRI- 105

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767935557  85 itkcNEIESHIIKQEDILNGKENEIKELQQVISQQKQ 121
Cdd:COG1579  106 ----SDLEDEILELMERIEELEEELAELEAELAELEA 138
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
3-121 5.30e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.89  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   3 LQDENFVSKEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLE---KEKLAFEKALSSVKSKVLQESS 79
Cdd:COG4372   50 LREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELEslqEEAEELQEELEELQKERQDLEQ 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767935557  80 KKDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQ 121
Cdd:COG4372  130 QRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQ 171
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 11-121 7.19e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 7.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   11 KEEFQAVEKKLVEekaahaKTKVLLAKEEEKlqfalgevevlsKQLEKEKLAFEKALSSVKSKVLQESSKKDQLITKCNE 90
Cdd:TIGR04523 481 KQNLEQKQKELKS------KEKELKKLNEEK------------KELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISD 542

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767935557   91 IESHIIKQEDILN--GKENEIKELQQVISQQKQ 121
Cdd:TIGR04523 543 LEDELNKDDFELKkeNLEKEIDEKNKEIEELKQ 575
PRK12704 PRK12704
phosphodiesterase; Provisional
 9-122 1.29e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   9 VSKEEFQAveKKLVEEkaahAKTKVLLAKEEEKLQfALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQES---SKKDQLI 85
Cdd:PRK12704  33 IKEAEEEA--KRILEE----AKKEAEAIKKEALLE-AKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEenlDRKLELL 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767935557  86 TKcneIESHIIKQEDILNGKENEIKELQQVIS--QQKQI 122
Cdd:PRK12704 106 EK---REEELEKKEKELEQKQQELEKKEEELEelIEEQL 141
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
11-121 1.38e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 1.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557  11 KEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKS-----KVLQES-----SK 80
Cdd:COG4372   44 QEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESlqeeaEELQEEleelqKE 123

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767935557  81 KDQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQ 121
Cdd:COG4372  124 RQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQE 164
DUF4200 pfam13863
Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil ...
 11-122 3.88e-03

Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.


Pssm-ID: 464003 [Multi-domain]  Cd Length: 119  Bit Score: 36.78  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   11 KEEFQaVEKKLVEEKAAHAKTKVLLAKEEEKLqfalgevEVLSKQLEKEKLAFEKALSSVKSKVLQESSKKDQlitkcnE 90
Cdd:pfam13863   6 REMFL-VQLALDAKREEIERLEELLKQREEEL-------EKKEQELKEDLIKFDKFLKENDAKRRRALKKAEE------E 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 767935557   91 IESHIIKQEDILNgKENEIKELQQVISQQKQI 122
Cdd:pfam13863  72 TKLKKEKEKEIKK-LTAQIEELKSEISKLEEK 102
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 15-115 4.30e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 38.47  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557   15 QAVEKKL--VEEKAAHAKTKvlLAKEEEKLQFALGEVEVLSK---QLEKEKLAFEKALSSVKSKVLQESSKKDQLITKCN 89
Cdd:pfam00261   4 QQIKEELdeAEERLKEAMKK--LEEAEKRAEKAEAEVAALNRriqLLEEELERTEERLAEALEKLEEAEKAADESERGRK 81

                          90       100
                  ....*....|....*....|....*.
gi 767935557   90 EIESHIIKQEDILNGKENEIKELQQV 115
Cdd:pfam00261  82 VLENRALKDEEKMEILEAQLKEAKEI 107
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 12-116 8.19e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 38.23  E-value: 8.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557    12 EEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKAlSSVKSKVlqeSSKKDQLITKCNEI 91
Cdd:pfam01576    5 EEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEA-EEMRARL---AARKQELEEILHEL 80

                           90       100
                   ....*....|....*....|....*
gi 767935557    92 ESHIIKQEDILNGKENEIKELQQVI 116
Cdd:pfam01576   81 ESRLEEEEERSQQLQNEKKKMQQHI 105
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
 3-122 8.49e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 37.69  E-value: 8.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557     3 LQDENFVSKEEFQaVEKKLVEEKAAHAKTkvLLAKEEEKLQFALGEVEVLSKQLEKeklaFEKALSSVKSKVLQESSKKD 82
Cdd:smart00787 177 LRDRKDALEEELR-QLKQLEDELEDCDPT--ELDRAKEKLKKLLQEIMIKVKKLEE----LEEELQELESKIEDLTNKKS 249

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767935557    83 QLITKCNEIEShiiKQEDILNGKENEIKELQQVISQQKQI 122
Cdd:smart00787 250 ELNTEIAEAEK---KLEQCRGFTFKEIEKLKEQLKLLQSL 286
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 2-124 8.66e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 38.18  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557    2 VLQDENFVSKEEFQAVEKKLVEEKAAHAkTKVLLAKEEEKLQFALGEVEVLSKQLEKEKLAFEKALSSVKSKVLQEsskk 81
Cdd:pfam05557  11 LSQLQNEKKQMELEHKRARIELEKKASA-LKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYL---- 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767935557   82 DQLITKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQIFS 124
Cdd:pfam05557  86 EALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQ 128
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 11-121 9.96e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 38.03  E-value: 9.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935557    11 KEEFQAVEKKLVEEKAAHAKTKVLLAKEEEKLQFA-----LGEVEVLSKQLEKEKLAFEKALSSVKSKVLQESSKKDQLI 85
Cdd:pfam02463  192 LEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLlyldyLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVL 271

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 767935557    86 TKCNEIESHIIKQEDILNGKENEIKELQQVISQQKQ 121
Cdd:pfam02463  272 KENKEEEKEKKLQEEELKLLAKEEEELKSELLKLER 307
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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