NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767935562|ref|XP_011541557|]
View 

coiled-coil domain-containing protein 125 isoform X1 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000037)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 111-256 5.01e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 5.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935562 111 EELRQCLNETLEEVEMLKTELEASQRQLRGKEEALKILQSMAilgkatshtqAVLQKTMEQNRSlEKEINALQWEIEFDH 190
Cdd:COG1579   34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARI----------KKYEEQLGNVRN-NKEYEALQKEIESLK 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767935562 191 NRFKNIEESWIQKYDRLncenAVLKENLKVKTEEIKMLKSDNAVLNQRYLEALAMLDIKQQKMAQE 256
Cdd:COG1579  103 RRISDLEDEILELMERI----EELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE 164
 
Name Accession Description Interval E-value
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 111-256 5.01e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 5.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935562 111 EELRQCLNETLEEVEMLKTELEASQRQLRGKEEALKILQSMAilgkatshtqAVLQKTMEQNRSlEKEINALQWEIEFDH 190
Cdd:COG1579   34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARI----------KKYEEQLGNVRN-NKEYEALQKEIESLK 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767935562 191 NRFKNIEESWIQKYDRLncenAVLKENLKVKTEEIKMLKSDNAVLNQRYLEALAMLDIKQQKMAQE 256
Cdd:COG1579  103 RRISDLEDEILELMERI----EELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE 164
 
Name Accession Description Interval E-value
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 111-256 5.01e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 5.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767935562 111 EELRQCLNETLEEVEMLKTELEASQRQLRGKEEALKILQSMAilgkatshtqAVLQKTMEQNRSlEKEINALQWEIEFDH 190
Cdd:COG1579   34 AELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARI----------KKYEEQLGNVRN-NKEYEALQKEIESLK 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767935562 191 NRFKNIEESWIQKYDRLncenAVLKENLKVKTEEIKMLKSDNAVLNQRYLEALAMLDIKQQKMAQE 256
Cdd:COG1579  103 RRISDLEDEILELMERI----EELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAE 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH