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Conserved domains on  [gi|767912620|ref|XP_011542565|]
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probable methyltransferase TARBP1 isoform X2 [Homo sapiens]

Protein Classification

TrmH family RNA methyltransferase( domain architecture ID 13031009)

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

CATH:  3.40.1280.10
EC:  2.1.1.-
Gene Ontology:  GO:0008173|GO:1904047|GO:0003723|GO:0032259
PubMed:  11763972|17338813|30457841|18029778
SCOP:  3001122

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 1440-1584 1.23e-84

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


:

Pssm-ID: 349964  Cd Length: 145  Bit Score: 272.87  E-value: 1.23e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1440 LIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGV 1519
Cdd:cd18091     1 LIVVASLIDKPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKALSVSAEKWLPIEEVKPEDLLPYLKEKKQEGYTIVGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620 1520 EQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEY 1584
Cdd:cd18091    81 EQTANSVSLHDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYEY 145
COG3903 super family cl43979
Predicted ATPase [General function prediction only];
17-301 4.81e-03

Predicted ATPase [General function prediction only];


The actual alignment was detected with superfamily member COG3903:

Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.54  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620   17 RALLGALCQGEASAERVETLRFLLQRLEDEEA--RGSGGAGALPEAAREVAAGYLVPLLRSLRGRPAGGPDPSLQ--PRH 92
Cdd:COG3903   499 LALAERAAAELRGPDQLAWLARLDAEHDNLRAalRWALAHGDAELALRLAAALAPFWFLRGLLREGRRWLERALAaaGEA 578

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620   93 RRRVLRAAGAALRSCVRLAGRPQLAAALAEEALRD----------LLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLLER 162
Cdd:COG3903   579 AAALAAAAALAAAAAAARAAAAAAAAAAAAAAAAAaaaaaaaaalLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 658

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  163 VAGTAVALALGGGGDGDEAGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPGASLGSGRVEEKLLVLSALAEKLLP 242
Cdd:COG3903   659 AAAAAAALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAA 738

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767912620  243 EPGGDRARGAREAGPDARRCWRFWRTVQAGLGQADALTRKRARYLLQRAVEVSAELGAD 301
Cdd:COG3903   739 AAAAAALALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAAA 797
 
Name Accession Description Interval E-value
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 1440-1584 1.23e-84

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 272.87  E-value: 1.23e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1440 LIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGV 1519
Cdd:cd18091     1 LIVVASLIDKPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKALSVSAEKWLPIEEVKPEDLLPYLKEKKQEGYTIVGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620 1520 EQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEY 1584
Cdd:cd18091    81 EQTANSVSLHDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYEY 145
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 1440-1582 5.56e-35

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 130.73  E-value: 5.56e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  1440 LIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQC--ISDKQFQHLSVSAEQWLPLVEVkpPQLIDYLQQKKTEGYTII 1517
Cdd:pfam00588    2 LVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSadPYNPKAIRASAGALFHLPLVVV--DNLEEALKDLKEAGYAVV 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620  1518 GVEQTAKslDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIW 1582
Cdd:pfam00588   80 ATSLGGK--SLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 1415-1589 2.80e-20

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 92.57  E-value: 2.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1415 SRVSDLDLELLFQDRAArlgksiSRLIVVASLIDKPTNLGGLCRTCEVFGASVLVV--GSLQCISDKqfqhlsV------ 1486
Cdd:COG0566    97 RPPEYADLEDLLAEAGE------PPLLLVLDGVQDPGNLGAILRSAAAFGVDGVILpkRRADPYNPK------Vvrasag 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1487 SAEQwLPLVEVKPpqLIDYLQQKKTEGYTIIGVEQTAKSlDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQG 1566
Cdd:COG0566   165 ALFH-VPVARVTN--LADALEELKEAGFWVVGTDLDGEA-SLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAG 240

                         170       180
                  ....*....|....*....|...
gi 767912620 1567 IIRSLNVHVSGALLIWEYTRQQL 1589
Cdd:COG0566   241 GVESLNVAVAAAILLYEAARQRR 263
PRK10864 PRK10864
putative methyltransferase; Provisional
 1450-1588 2.39e-14

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 76.36  E-value: 2.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1450 PTNLGGLCRTCEVFG-ASVLVVGSLQCISDKQFQHLSVSAEQwlplveVKP---PQLIDYLQQKKTEGYTIIgVEQTAKS 1525
Cdd:PRK10864  209 PHNLGGIMRSCAHFGvKGVVVQDAALLESGAAIRTAEGGAEH------VQPitgDSFVDVLDDFRQAGYTIV-TTSSHKG 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767912620 1526 LDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQ 1588
Cdd:PRK10864  282 TPLFKASLPAKMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQN 344
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 1435-1587 2.31e-13

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 71.61  E-value: 2.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  1435 KSISRLIVVASLIDkPTNLGGLCRTCEVFGASVLVV-----GSLQCISDKqfqhLSVSAEQWLPLVEVkpPQLIDYLQQK 1509
Cdd:TIGR00186   87 KKQPFLLILDEITD-PHNLGAILRTAEAFGVDGVILpkrrsAPLNSTVVK----TSSGAVEYVPLARV--TNLSRTITKL 159

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767912620  1510 KTEGYTIIGVEQTAKSLDLTQYCFpEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQ 1587
Cdd:TIGR00186  160 KESGFWTVGTDLDAQDTLYQVKLT-KPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQ 236
COG3903 COG3903
Predicted ATPase [General function prediction only];
17-301 4.81e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.54  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620   17 RALLGALCQGEASAERVETLRFLLQRLEDEEA--RGSGGAGALPEAAREVAAGYLVPLLRSLRGRPAGGPDPSLQ--PRH 92
Cdd:COG3903   499 LALAERAAAELRGPDQLAWLARLDAEHDNLRAalRWALAHGDAELALRLAAALAPFWFLRGLLREGRRWLERALAaaGEA 578

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620   93 RRRVLRAAGAALRSCVRLAGRPQLAAALAEEALRD----------LLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLLER 162
Cdd:COG3903   579 AAALAAAAALAAAAAAARAAAAAAAAAAAAAAAAAaaaaaaaaalLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 658

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  163 VAGTAVALALGGGGDGDEAGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPGASLGSGRVEEKLLVLSALAEKLLP 242
Cdd:COG3903   659 AAAAAAALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAA 738

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767912620  243 EPGGDRARGAREAGPDARRCWRFWRTVQAGLGQADALTRKRARYLLQRAVEVSAELGAD 301
Cdd:COG3903   739 AAAAAALALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAAA 797
 
Name Accession Description Interval E-value
SpoU-like_TRM3-like cd18091
SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O) ...
 1440-1584 1.23e-84

SAM-dependent tRNA methylase related to TRM3; Yeast tRNA (guanosine(18)-2'-O)-methyltransferase TRM3 catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in various tRNAs. TRM3 is similar to C-terminal domain of TAR (HIV-1) RNA binding protein 1 (TARBP1), a protein binding to TAR, which functions as a RNA regulatory signal by forming a stable stem-loop structure to which transactivator protein Tat binds. The role of TARBP1 is believed to be to disengage RNA polymerase II from TAR during transcriptional elongation. TRM3 and the C-terminal methyltransferase domain of TARBP1 are members of the SPOUT methyltransferase superfamily.


Pssm-ID: 349964  Cd Length: 145  Bit Score: 272.87  E-value: 1.23e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1440 LIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTIIGV 1519
Cdd:cd18091     1 LIVVASLIDKPPNLGGLCRTCEIFGVSKLVLPNLAVVEDKQFKALSVSAEKWLPIEEVKPEDLLPYLKEKKQEGYTIVGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620 1520 EQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEY 1584
Cdd:cd18091    81 EQTANSVSLHDFQFPKKTVLVLGNEKEGIPAELLSLLDVCVEIPQLGVIRSLNVHVSGAIAIYEY 145
SpoU-like_family cd18082
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 1441-1584 3.37e-39

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349955  Cd Length: 145  Bit Score: 142.75  E-value: 3.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1441 IVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQCISDKQF-QHLSVSAEQWLPLVEVKPPqlIDYLQQKKTEGYTIIGV 1519
Cdd:cd18082     1 HLVLDNIRSPGNIGSIFRTADAFGVEKIYLVGPTADIFDPKaKRTSRGTHFSVPYERVDNF--EEYLKSLKEEGYPLIGL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767912620 1520 EQTAKSLDLTQYCF--PEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEY 1584
Cdd:cd18082    79 ELTDGSIPLSEFKFkkPKKIALIFGNERSGLSPELLALCDYTVHIPMSGKNSSLNVSVATGIALYEF 145
SpoU_methylase pfam00588
SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.
 1440-1582 5.56e-35

SpoU rRNA Methylase family; This family of proteins probably use S-AdoMet.


Pssm-ID: 425768  Cd Length: 142  Bit Score: 130.73  E-value: 5.56e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  1440 LIVVASLIDKPTNLGGLCRTCEVFGASVLVVGSLQC--ISDKQFQHLSVSAEQWLPLVEVkpPQLIDYLQQKKTEGYTII 1517
Cdd:pfam00588    2 LVVVLDNIQDPGNLGAIIRTAAAFGADGLILVEPRSadPYNPKAIRASAGALFHLPLVVV--DNLEEALKDLKEAGYAVV 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620  1518 GVEQTAKslDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIW 1582
Cdd:pfam00588   80 ATSLGGK--SLYEIDFPKKVALVFGNEGTGLSNEVLELCDRLVRIPMSGDVESLNVAVAAAIALY 142
SpoU-like cd18097
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 1440-1583 4.66e-22

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349970  Cd Length: 144  Bit Score: 93.78  E-value: 4.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1440 LIVVASLIDKPTNLGGLCRTCEVFGAS-VLVVGSLQCISDKQFQHLSVSAEQWLPlVEvKPPQLIDYLQQKKTEGYTIIG 1518
Cdd:cd18097     1 LVVVLDNLRSAHNVGSIFRTADAAGVEkIYLCGYTPTPPHPKVAKTALGAEESVP-WE-HFEDTLEAVRALKARGYTIIA 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620 1519 VEQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWE 1583
Cdd:cd18097    79 LETTENSVPLHEARLPRPLALVLGNEVRGVSPEVLALCDAVVEIPMFGRKNSLNVAVAAAVALYE 143
SpoU COG0566
tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA ...
 1415-1589 2.80e-20

tRNA G18 (ribose-2'-O)-methylase SpoU [Translation, ribosomal structure and biogenesis]; tRNA G18 (ribose-2'-O)-methylase SpoU is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440332 [Multi-domain]  Cd Length: 265  Bit Score: 92.57  E-value: 2.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1415 SRVSDLDLELLFQDRAArlgksiSRLIVVASLIDKPTNLGGLCRTCEVFGASVLVV--GSLQCISDKqfqhlsV------ 1486
Cdd:COG0566    97 RPPEYADLEDLLAEAGE------PPLLLVLDGVQDPGNLGAILRSAAAFGVDGVILpkRRADPYNPK------Vvrasag 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1487 SAEQwLPLVEVKPpqLIDYLQQKKTEGYTIIGVEQTAKSlDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQG 1566
Cdd:COG0566   165 ALFH-VPVARVTN--LADALEELKEAGFWVVGTDLDGEA-SLYEVDLPGPVALVLGNEGKGLSRLVLEACDELVRIPMAG 240

                         170       180
                  ....*....|....*....|...
gi 767912620 1567 IIRSLNVHVSGALLIWEYTRQQL 1589
Cdd:COG0566   241 GVESLNVAVAAAILLYEAARQRR 263
SpoU-like_TrmH cd18092
SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group ...
 1428-1587 1.34e-19

SAM-dependent tRNA methylase related to TrmH; TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349965  Cd Length: 162  Bit Score: 87.52  E-value: 1.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1428 DRAAR----LGKSISRLIVVASLIDKPTNLGGLCRTCEVFGasvlvVGSLQCISD----KQFQHLSVSAEQWLPLVEVKP 1499
Cdd:cd18092     1 ERLERieevLARRTRDLTVVLENVHDPHNASAVLRTCDAFG-----VQDVHVIEPknkfKKNRGVAMGADKWLDVHRHDS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1500 P-QLIDYLqqkKTEGYTIIGVEQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGA 1578
Cdd:cd18092    76 TeECLAAL---KEQGYRIVATSLSPDAVPLDELDYTRPTALVFGNEKDGVSEEALAAADERVYIPMYGFVESLNVSVAAA 152


                  ....*....
gi 767912620 1579 LLIWEYTRQ 1587
Cdd:cd18092   153 IILYELQRQ 161
SpoU-like_RlmB cd18103
SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the ...
 1440-1584 5.15e-19

SAM-dependent rRNA methylase related to RlmB; 23S rRNA-M2G2251-MTase RlmB catalyzes the methylation of guanosine 2251, a modification conserved in the peptidyltransferase domain of 23S rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349976  Cd Length: 143  Bit Score: 85.13  E-value: 5.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1440 LIVVASLIDKPTNLGGLCRTCEVFGASVLVvgslqcISDKQFQHL-------SVSAEQWLPLVEVK-PPQLIDYLQQKkt 1511
Cdd:cd18103     1 LLLILDGITDPHNLGAIIRSAEAFGVDGVI------IPKRRSAPLtptvakaSAGALEHLPIARVTnLARALEELKEA-- 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767912620 1512 eGYTIIGVEQTAKSlDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEY 1584
Cdd:cd18103    73 -GFWIYGADGEAEK-SLYDVDLTGPLALVLGSEGKGLRRLVLKNCDFLVKIPMAGKVDSLNVSVAAGIILYEI 143
SpoU-like_rRNA-MTase cd18095
SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 1450-1584 1.47e-18

SAM-dependent rRNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349968  Cd Length: 143  Bit Score: 83.63  E-value: 1.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1450 PTNLGGLCRTCEVFGAS--VLVVGSLQCISDK--------QFQhlsvsaeqwLPLVEVkpPQLIDYLQQKKTEGYTIIGv 1519
Cdd:cd18095    11 PGNLGTIIRTAAAFGVDgvILSKGTVDPYNPKvvrasmgaLFR---------LPIIRV--DDLEELLEELKEAGYKVVA- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767912620 1520 eqTA--KSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEY 1584
Cdd:cd18095    79 --ADldGGSSLYDLDLPKPVALVLGNEGNGLSDELLELCDKRVTIPMSGGVESLNVAVAAAILLYEL 143
SpoU-like cd18096
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 1440-1584 2.63e-16

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349969  Cd Length: 140  Bit Score: 77.26  E-value: 2.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1440 LIVVASLIDKPTNLGGLCRTCEVFGAS-VLVVGSlqcisdKQF----QH---LSVSAEQWLPLVEVKppqliDYLQQKkt 1511
Cdd:cd18096     1 LYLVLHNVAKRHNIGTIVRSANAFGVKeVHLVGR------RKFnpfgAMgtdRHVKFRHFDTLAEAK-----EYLKER-- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767912620 1512 eGYTIIGVEQTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQG-IIRSLNVHVSGALLIWEY 1584
Cdd:cd18096    68 -GIRLVGVEIVPGAEPIETHPFPGDTAFVLGNEGTGLSDEQLAICDGFVYIPQYGsGTASLNVSVAASIVLHHF 140
PRK10864 PRK10864
putative methyltransferase; Provisional
 1450-1588 2.39e-14

putative methyltransferase; Provisional


Pssm-ID: 236779 [Multi-domain]  Cd Length: 346  Bit Score: 76.36  E-value: 2.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1450 PTNLGGLCRTCEVFG-ASVLVVGSLQCISDKQFQHLSVSAEQwlplveVKP---PQLIDYLQQKKTEGYTIIgVEQTAKS 1525
Cdd:PRK10864  209 PHNLGGIMRSCAHFGvKGVVVQDAALLESGAAIRTAEGGAEH------VQPitgDSFVDVLDDFRQAGYTIV-TTSSHKG 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767912620 1526 LDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQ 1588
Cdd:PRK10864  282 TPLFKASLPAKMVLVLGQEYDGLSDAARQQGDLSVSIDGTGNVESLNVSVATGVLLAEWWRQN 344
rRNA_methyl_3 TIGR00186
rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases ...
 1435-1587 2.31e-13

rRNA methylase, putative, group 3; this is part of the trmH (spoU) family of rRNA methylases [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129290 [Multi-domain]  Cd Length: 237  Bit Score: 71.61  E-value: 2.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  1435 KSISRLIVVASLIDkPTNLGGLCRTCEVFGASVLVV-----GSLQCISDKqfqhLSVSAEQWLPLVEVkpPQLIDYLQQK 1509
Cdd:TIGR00186   87 KKQPFLLILDEITD-PHNLGAILRTAEAFGVDGVILpkrrsAPLNSTVVK----TSSGAVEYVPLARV--TNLSRTITKL 159

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767912620  1510 KTEGYTIIGVEQTAKSLDLTQYCFpEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQ 1587
Cdd:TIGR00186  160 KESGFWTVGTDLDAQDTLYQVKLT-KPLALVVGNEGEGVSRLIKENCDFLIKIPMAGKVDSLNVSVAAGILLFEIKRQ 236
SpoU-like_MRM1 cd18105
SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose ...
 1450-1583 3.41e-13

SAM-dependent rRNA methylase related to MRM1; MRM1 catalyzes the methylation of 2'-O-ribose residues G1145 to GmG residue of the mitochondrial 16S rRNA. MRM1 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349978  Cd Length: 158  Bit Score: 68.70  E-value: 3.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1450 PTNLGGLCRTCEVFGASVLVVgslqciSDKQFQHLS--VS-----AEQWLPLVEVKPPQliDYLQQKKTEGYTIIG---- 1518
Cdd:cd18105    11 PQNLGAILRSAYFLGVDGVVV------SSKNSAPLSpvVSkasagALELMPIYSVDNLA--SFLKSSKENGWKVVGtsap 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620 1519 --VEQTAKSLDLTQYCFPEKS---LLLLGNEREGIPANLIQQLDVCVEIPQ-----QGIIRSLNVHVSGALLIWE 1583
Cdd:cd18105    83 psASSDKKTIPANELSELLLEkptILVLGNEGRGLRTNIKNLCDYLVSIPGgrsaeNPGVDSLNVSVAAGILLHS 157
SpoU-like_AviRb cd18107
SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes ...
 1446-1583 1.37e-11

SAM-dependent rRNA methylase related to AviRb; AviRb from Streptomyces viridochromogenes methylates the 2'-O atom of U2479 of the 23S ribosomal RNA. AviRb is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349980  Cd Length: 148  Bit Score: 63.95  E-value: 1.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1446 LIDKPT---NLGGLCRTCEVFGASVLVV-GSLQCISDKQFQHLSVSAEQWLPLVEVKPP-QLIDYLQ--QKKTEGYTIIG 1518
Cdd:cd18107     4 LFDRPTspgNLGTIIRSADALGAHGLVVtGHAADVYDPKTIRASTGSLFSLPIVRVPSNrELEDWVEarKARGTPLQLVG 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767912620 1519 VEqTAKSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWE 1583
Cdd:cd18107    84 TD-EHGDHQIADHDFTRPTLLLIGNETAGLSAAWRELCDETVSIPMAGSASSLNAACAASIFLYE 147
SpoU-like cd18098
SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase ...
 1449-1586 3.21e-11

SAM-dependent rRNA or tRNA methylase related to SpoU; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349971  Cd Length: 138  Bit Score: 62.67  E-value: 3.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1449 KPTNLGGLCRTCEVFGASVLVVgslqcISDKQFQHLSVS----AEQWLPLVEVkpPQLIDYLQQKkTEGYTIIGVEQTAK 1524
Cdd:cd18098    10 TPKNVGTLWRAAGCLGASFVFT-----IGARYKRRKQSTdtskAWRHIPLFHY--DDLEDLAEPL-PFGAVLVAVELTEG 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767912620 1525 SLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGiirSLNVHVSGALLIweYTR 1586
Cdd:cd18098    82 ATPLPDFKHPDRAVYLLGPEDGGLPQEVLARCHHVVYLPTRG---SLNVAVAGSIVL--YDR 138
SpoU-like_TrmL cd18094
SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL ...
 1448-1588 9.35e-10

SAM-dependent tRNA methylase related to TrmL; tRNA (Um34/Cm34) methyltransferase TrmL catalyzes the methyl transfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH at position 34 in both tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349967  Cd Length: 145  Bit Score: 58.62  E-value: 9.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1448 DKPTNLGGLCRTCEVFGASVLVVGSLQ-CISDKqfqHLSVSAEQWLPLVEVKP-PQLIDYLqqKKTEGYTIIGVEQTAKS 1525
Cdd:cd18094     8 EIPQNTGNIARTCAATGARLHLIEPLGfSLDDK---RLKRAGLDYWDHVDLTVhDSWEAFL--EALPPGRLFLFTTKGTK 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767912620 1526 LdLTQYCFPEKSLLLLGNEREGIPANLIQQ-LDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQ 1588
Cdd:cd18094    83 P-YTDFDFKPGDYLVFGRESTGLPEEILDAfPDRRLRIPMRPKVRSLNLSNSVAIVLYEALRQL 145
SpoU-like_RNA-MTase cd18109
SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes ...
 1450-1584 1.56e-08

SAM-dependent RNA methylase related to SpoU-TrmH; RNA 2'-O ribose methyltransferase catalyzes the methyltransfer from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of ribose in tRNA or rRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349982  Cd Length: 141  Bit Score: 54.85  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1450 PTNLGGLCRTCEVFGAS--VLVVGSLQCISDKQFQHlSVSAEQWLPLVEVKPPQLIDYLQQKktegYTIIGVeqTAKSLD 1527
Cdd:cd18109    11 PGNLGTIIRTADWFGIRqiICSPDTVDPYNPKVVQA-SMGSIFRVQIHYTDLPALLAELKKA----FPVYGA--DLDGEN 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767912620 1528 LTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQG-IIRSLNVHVSGALLIWEY 1584
Cdd:cd18109    84 LYEFTLPEKGILVMGNEGHGISPEVLKLLTHRLTIPRYGkGAESLNVAVATAILLSEF 141
PRK11081 PRK11081
tRNA guanosine-2'-O-methyltransferase; Provisional
 1449-1587 2.58e-07

tRNA guanosine-2'-O-methyltransferase; Provisional


Pssm-ID: 236837 [Multi-domain]  Cd Length: 229  Bit Score: 53.46  E-value: 2.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1449 KPTNLGGLCRTCEVFGasvlvVGSLQCI-SDKQFQHLSVSA---EQWlplVEVKPPQLI-DYLQQKKTEGYTIIGVEQTA 1523
Cdd:PRK11081   29 KPHNVSAIIRTADAVG-----VHEVHAVwPGSRMRTMGSTAagsNSW---VQVKTHRTIgDAVAHLKGQGMQILATHLSD 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767912620 1524 KSLDLTQYCFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWEYTRQ 1587
Cdd:PRK11081  101 TAVDFREIDYTRPTCILMGQEKTGISQEALALADQDIIIPMIGMVQSLNVSVASALILYEAQRQ 164
TrmL COG0219
tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ...
 1529-1588 3.35e-05

tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain [Translation, ribosomal structure and biogenesis]; tRNA(Leu) C34 or U34 (ribose-2'-O)-methylase TrmL, contains SPOUT domain is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439989  Cd Length: 153  Bit Score: 45.79  E-value: 3.35e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767912620 1529 TQYCFPEKSLLLLGNEREGIPANLIQQL-DVCVEIPQQGIIRSLNVHVSGALLIWEYTRQQ 1588
Cdd:COG0219    87 TDVDYQPGDVLLFGRETAGLPEEVLAAPaDQRLRIPMRPGVRSLNLSNAVAIVLYEALRQL 147
SpoU-like_NHR cd18108
Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) ...
 1452-1583 1.92e-04

Nosiheptide-resistance methyltransferase (NHR); Nosiheptide-resistance methyltransferase (NHR) confers resistance to the thiazole antibiotic nosiheptide via catalyzing 2'O-methylation of 23S rRNA at the nucleotide A1067. NHR is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349981  Cd Length: 144  Bit Score: 43.24  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620 1452 NLGGLCRTCEVFGAS--VLVVGSLQCISDKQFQHLSVSAEQWLPLVEVKPPQLIDYLQQKKTEGYTI-----IGVEqtak 1524
Cdd:cd18108    13 NIGAIVRTSLALGAAgiVLVDSDLATVADRRLLRASRGYVFSLPVVLADREEAVAFLRDNDIPLMTLdadgdVPVK---- 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767912620 1525 slDLTQycFPEKSLLLLGNEREGIPANLIQQLDVCVEIPQQGIIRSLNVHVSGALLIWE 1583
Cdd:cd18108    89 --ELGD--RPDRLALVFGSEKGGPSGLFEEAAAGTVSIPMSSSTESLNVSVSAGIALHE 143
COG3903 COG3903
Predicted ATPase [General function prediction only];
17-301 4.81e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 41.54  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620   17 RALLGALCQGEASAERVETLRFLLQRLEDEEA--RGSGGAGALPEAAREVAAGYLVPLLRSLRGRPAGGPDPSLQ--PRH 92
Cdd:COG3903   499 LALAERAAAELRGPDQLAWLARLDAEHDNLRAalRWALAHGDAELALRLAAALAPFWFLRGLLREGRRWLERALAaaGEA 578

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620   93 RRRVLRAAGAALRSCVRLAGRPQLAAALAEEALRD----------LLAGWRAPGAEAAVEVLAAVGPCLRPREDGPLLER 162
Cdd:COG3903   579 AAALAAAAALAAAAAAARAAAAAAAAAAAAAAAAAaaaaaaaaalLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 658

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  163 VAGTAVALALGGGGDGDEAGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGLAAPGASLGSGRVEEKLLVLSALAEKLLP 242
Cdd:COG3903   659 AAAAAAALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAA 738

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767912620  243 EPGGDRARGAREAGPDARRCWRFWRTVQAGLGQADALTRKRARYLLQRAVEVSAELGAD 301
Cdd:COG3903   739 AAAAAALALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAAA 797
COG3903 COG3903
Predicted ATPase [General function prediction only];
6-300 8.07e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 40.77  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620    6 AEALLSQS--RDPRALLGALC-----QGEASAERV-----ETLR-FLLQRLEDeeargsggAGALPEAAREVAAGYLVpL 72
Cdd:COG3903   431 AEAVCGGDgpADVLDLLAALVdksllEVEGGGGGPryrllETVReYAAERLAE--------AGERAAARRRHADYYLA-L 501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620   73 LRSLRGRPAGGPDPSLQPRHRRRV--LRAA----------GAALRSCVRLA------GRPQLAAALAEealrdllAGWRA 134
Cdd:COG3903   502 AERAAAELRGPDQLAWLARLDAEHdnLRAAlrwalahgdaELALRLAAALApfwflrGLLREGRRWLE-------RALAA 574

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  135 PGAEAAVEVLAAVGPCLRPREDGPLLERVAGTAVALALGGGGDGDEAGPAEDAAALVAGRLLPVLVQCGGAALRAVWGGL 214
Cdd:COG3903   575 AGEAAAALAAAAALAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAA 654

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912620  215 AAPGASLGSGRVEekLLVLSALAEKLLPEPGGDRARGAREAGPDARRCWRFWRTVQAGLGQADALTRKRARYLLQRAVEV 294
Cdd:COG3903   655 AAAAAAAAAAALA--AAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAA 732


                  ....*.
gi 767912620  295 SAELGA 300
Cdd:COG3903   733 AAALAA 738
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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