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Conserved domains on  [gi|767951201|ref|XP_011542944|]
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homeobox-containing protein 1 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 25-227 5.18e-60

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461440  Cd Length: 178  Bit Score: 186.95  E-value: 5.18e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951201   25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLDPEFGVKlESLPLSPGSSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951201   99 PSPSNSYDTSPQPcttnqNGRENNERLSTsngkmsptryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNSYDTPPIL-----DLGGELGDLDP-------------------------EEAAEQRAEVEELLREDPWRVAEMIK 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767951201  179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 25-227 5.18e-60

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 186.95  E-value: 5.18e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951201   25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLDPEFGVKlESLPLSPGSSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951201   99 PSPSNSYDTSPQPcttnqNGRENNERLSTsngkmsptryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNSYDTPPIL-----DLGGELGDLDP-------------------------EEAAEQRAEVEELLREDPWRVAEMIK 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767951201  179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 162-206 5.39e-04

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.08  E-value: 5.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767951201 162 VEELMRRD------SSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWL 206
Cdd:COG3620    1 VRDLMSRDvvtvspDDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIE 51
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 175-205 4.54e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 34.45  E-value: 4.54e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767951201 175 EEIKAFLANRRISQAVVAQVTGISQSRISHW 205
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRI 32
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 25-227 5.18e-60

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 186.95  E-value: 5.18e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951201   25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 EQIELLQRLLRSGLTKEELIHALEELEPLDPEFGVKlESLPLSPGSSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767951201   99 PSPSNSYDTSPQPcttnqNGRENNERLSTsngkmsptryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNSYDTPPIL-----DLGGELGDLDP-------------------------EEAAEQRAEVEELLREDPWRVAEMIK 130

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767951201  179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 162-206 5.39e-04

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 38.08  E-value: 5.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767951201 162 VEELMRRD------SSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWL 206
Cdd:COG3620    1 VRDLMSRDvvtvspDDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIE 51
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
 164-217 1.27e-03

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 36.82  E-value: 1.27e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767951201  164 ELMRRdssvIKEEIKAflanRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQK 217
Cdd:pfam13744  18 QLARA----IARLIEG----RGLSQQEAAALLGIAQPKVSALLKGKLSRFSLDK 63
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
166-205 1.53e-03

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 36.51  E-value: 1.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767951201 166 MRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHW 205
Cdd:COG1396    1 MSTLKKALGERLRELRKARGLTQEELAERLGVSRSTISRI 40
COG5606 COG5606
Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];
164-204 3.66e-03

Predicted DNA-binding protein, XRE-type HTH domain [General function prediction only];


Pssm-ID: 444337  Cd Length: 105  Bit Score: 36.01  E-value: 3.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767951201 164 ELMRrdssvikeEIKAFLANRRISQAVVAQVTGISQSRISH 204
Cdd:COG5606   32 QLMA--------AIRKLIKERGLTQAEAAELLGITQPRVSD 64
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 175-205 4.54e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 34.45  E-value: 4.54e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767951201 175 EEIKAFLANRRISQAVVAQVTGISQSRISHW 205
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRI 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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