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Conserved domains on  [gi|767968135|ref|XP_011543316|]
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dnaJ homolog subfamily B member 13 isoform X6 [Homo sapiens]

Protein Classification

J domain-containing protein( domain architecture ID 1001220)

J domain-containing protein similar to molecular chaperone DnaJ, part of the DnaK-DnaJ-GrpE system, prevents the aggregation of unfolded substrate and acts primarily by stimulating the ATPase activity of Hsp70

CATH:  1.10.287.110
Gene Ontology:  GO:0006457
PubMed:  9644977|8016869|15170475
SCOP:  4000605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaJ_bact super family cl37091
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 48-146 6.61e-22

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


The actual alignment was detected with superfamily member TIGR02349:

Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 91.89  E-value: 6.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135   48 HSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiPLEFGSQTPWTTGYVFh 127
Cdd:TIGR02349  11 DASEEEIKKAYRKLAKKYHPDRNKDKEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGG-GGGGGGGFNGFDIGFF- 88

                          90
                  ....*....|....*....
gi 767968135  128 GKPEKVFHEFFGGNNPFSG 146
Cdd:TIGR02349  89 GDFGDIFGDFFGGGGGSGR 107
 
Name Accession Description Interval E-value
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 48-146 6.61e-22

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 91.89  E-value: 6.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135   48 HSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiPLEFGSQTPWTTGYVFh 127
Cdd:TIGR02349  11 DASEEEIKKAYRKLAKKYHPDRNKDKEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGG-GGGGGGGFNGFDIGFF- 88

                          90
                  ....*....|....*....
gi 767968135  128 GKPEKVFHEFFGGNNPFSG 146
Cdd:TIGR02349  89 GDFGDIFGDFFGGGGGSGR 107
terminal_TopJ NF037946
terminal organelle assembly protein TopJ;
58-142 3.41e-19

terminal organelle assembly protein TopJ;


Pssm-ID: 468284 [Multi-domain]  Cd Length: 440  Bit Score: 84.87  E-value: 3.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFgsqtpwttgyvfhgKPEKVFHEF 137
Cdd:NF037946  26 FRKLAKKYHPDRNKAPDAAEIFAEINEAYEVLSNPEKRANYDKYGHDGVDGEGGFGF--------------DAFDVFSSF 91


                 ....*
gi 767968135 138 FGGNN 142
Cdd:NF037946  92 FETIN 96
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 42-148 3.57e-19

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 84.87  E-value: 3.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  42 VNIHLEHSTAEDKdQRYRRLALKHHPLKSNEPssaEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlefgsqtpwt 121
Cdd:PTZ00037  34 LNLSKDCTTSEIK-KAYRKLAIKHHPDKGGDP---EKFKEISRAYEVLSDPEKRKIYDEYGEEGLEGGEQ---------- 99

                         90       100
                 ....*....|....*....|....*..
gi 767968135 122 tgyvfHGKPEKVFHEFFGGNNPFSGMK 148
Cdd:PTZ00037 100 -----PADASDLFDLIFGGGRKPGGKK 121
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 50-106 1.71e-16

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 73.20  E-value: 1.71e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767968135  50 TAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGL 106
Cdd:COG0484   13 SAEEIKKAYRKLAKKYHPDRNpGDPEAEEKFKEINEAYEVLSDPEKRAAYDRFGHAAE 70
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 48-99 7.00e-16

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 69.04  E-value: 7.00e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767968135   48 HSTAEDKD--QRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYD 99
Cdd:pfam00226   9 SPDASDEEikKAYRKLALKYHPDKnPGDPEAEEKFKEINEAYEVLSDPEKRAIYD 63
DnaJ smart00271
DnaJ molecular chaperone homology domain;
47-94 1.35e-12

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 60.33  E-value: 1.35e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767968135    47 EHSTAEDKDQRYRRLALKHHP--LKSNEPSSAEIFRQIAEAYDVLSDPMK 94
Cdd:smart00271  11 RDASLDEIKKAYRKLALKYHPdkNPGDKEEAEEKFKEINEAYEVLSDPEK 60
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 47-91 1.72e-10

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 54.47  E-value: 1.72e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767968135  47 EHSTAEDKDQRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSD 91
Cdd:cd06257   10 PDASDEEIKKAYRKLALKYHPDKnPDDPEAEEKFKEINEAYEVLSD 55
 
Name Accession Description Interval E-value
DnaJ_bact TIGR02349
chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the ...
 48-146 6.61e-22

chaperone protein DnaJ; This model represents bacterial forms of DnaJ, part of the DnaK-DnaJ-GrpE chaperone system. The three components typically are encoded by consecutive genes. DnaJ homologs occur in many genomes, typically not near DnaK and GrpE-like genes; most such genes are not included by this family. Eukaryotic (mitochondrial and chloroplast) forms are not included in the scope of this family.


Pssm-ID: 274090 [Multi-domain]  Cd Length: 354  Bit Score: 91.89  E-value: 6.61e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135   48 HSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiPLEFGSQTPWTTGYVFh 127
Cdd:TIGR02349  11 DASEEEIKKAYRKLAKKYHPDRNKDKEAEEKFKEINEAYEVLSDPEKRAQYDQFGHAGFNGG-GGGGGGGFNGFDIGFF- 88

                          90
                  ....*....|....*....
gi 767968135  128 GKPEKVFHEFFGGNNPFSG 146
Cdd:TIGR02349  89 GDFGDIFGDFFGGGGGSGR 107
terminal_TopJ NF037946
terminal organelle assembly protein TopJ;
58-142 3.41e-19

terminal organelle assembly protein TopJ;


Pssm-ID: 468284 [Multi-domain]  Cd Length: 440  Bit Score: 84.87  E-value: 3.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFgsqtpwttgyvfhgKPEKVFHEF 137
Cdd:NF037946  26 FRKLAKKYHPDRNKAPDAAEIFAEINEAYEVLSNPEKRANYDKYGHDGVDGEGGFGF--------------DAFDVFSSF 91


                 ....*
gi 767968135 138 FGGNN 142
Cdd:NF037946  92 FETIN 96
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 42-148 3.57e-19

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 84.87  E-value: 3.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  42 VNIHLEHSTAEDKdQRYRRLALKHHPLKSNEPssaEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlefgsqtpwt 121
Cdd:PTZ00037  34 LNLSKDCTTSEIK-KAYRKLAIKHHPDKGGDP---EKFKEISRAYEVLSDPEKRKIYDEYGEEGLEGGEQ---------- 99

                         90       100
                 ....*....|....*....|....*..
gi 767968135 122 tgyvfHGKPEKVFHEFFGGNNPFSGMK 148
Cdd:PTZ00037 100 -----PADASDLFDLIFGGGRKPGGKK 121
PRK14298 PRK14298
chaperone protein DnaJ; Provisional
 49-140 1.05e-17

chaperone protein DnaJ; Provisional


Pssm-ID: 184612 [Multi-domain]  Cd Length: 377  Bit Score: 80.28  E-value: 1.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLE--FGSQTpwttgyvf 126
Cdd:PRK14298  17 ASVEDIKKAYRKLAMKYHPDKNKEPDAEEKFKEISEAYAVLSDAEKRAQYDRFGHAGIDNQYSAEdiFRGAD-------- 88

                         90
                 ....*....|....
gi 767968135 127 HGKPEKVFHEFFGG 140
Cdd:PRK14298  89 FGGFGDIFEMFFGG 102
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 49-140 2.99e-17

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 79.04  E-value: 2.99e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlEFGSQTPWTTgyVFHG 128
Cdd:PRK14291  15 ATQEEIKKAYRRLARKYHPDFNKNPEAEEKFKEINEAYQVLSDPEKRKLYDQFGHAAFSGSGQ-QQQGQEGFSD--FGGG 91

                         90
                 ....*....|..
gi 767968135 129 KPEKVFHEFFGG 140
Cdd:PRK14291  92 NIEDILEDVFDI 103
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 50-106 1.71e-16

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 73.20  E-value: 1.71e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767968135  50 TAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGL 106
Cdd:COG0484   13 SAEEIKKAYRKLAKKYHPDRNpGDPEAEEKFKEINEAYEVLSDPEKRAAYDRFGHAAE 70
PRK10767 PRK10767
chaperone protein DnaJ; Provisional
 50-140 2.00e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 236757 [Multi-domain]  Cd Length: 371  Bit Score: 76.72  E-value: 2.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  50 TAEDKD--QRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLE-FGSQTPwttgyv 125
Cdd:PRK10767  15 NASEDEikKAYRKLAMKYHPDRnPGDKEAEEKFKEIKEAYEVLSDPQKRAAYDQYGHAAFEQGGGGGgFGGGGG------ 88

                         90
                 ....*....|....*
gi 767968135 126 FHGKPEKVFHEFFGG 140
Cdd:PRK10767  89 FGDIFGDIFGDIFGG 103
PRK14280 PRK14280
molecular chaperone DnaJ;
49-140 2.52e-16

molecular chaperone DnaJ;


Pssm-ID: 237656 [Multi-domain]  Cd Length: 376  Bit Score: 76.30  E-value: 2.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGipleFGSQTPWTTGYVFHG 128
Cdd:PRK14280  16 ASKDEIKKAYRKLSKKYHPDINKEEGADEKFKEISEAYEVLSDDQKRAQYDQFGHAGPNQG----FGGGGFGGGDFGGGF 91

                         90
                 ....*....|..
gi 767968135 129 KPEKVFHEFFGG 140
Cdd:PRK14280  92 GFEDIFSSFFGG 103
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 58-140 4.00e-16

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 75.89  E-value: 4.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWTTGYVFhGKPEKVFHEF 137
Cdd:PRK14276  25 YRKLSKKYHPDINKEPGAEEKYKEVQEAYETLSDPQKRAAYDQYGAAGANGGFGGGAGGFGGFDGSGGF-GGFEDIFSSF 103


                 ...
gi 767968135 138 FGG 140
Cdd:PRK14276 104 FGG 106
PRK14293 PRK14293
molecular chaperone DnaJ;
49-155 5.68e-16

molecular chaperone DnaJ;


Pssm-ID: 237663 [Multi-domain]  Cd Length: 374  Bit Score: 75.41  E-value: 5.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG--GIPlEFGSQtpwttgyvf 126
Cdd:PRK14293  15 ADKDELKRAYRRLARKYHPDVNKEPGAEDRFKEINRAYEVLSDPETRARYDQFGEAGVSGaaGFP-DMGDM--------- 84

                         90       100
                 ....*....|....*....|....*....
gi 767968135 127 hGKPEKVFHEFFGGnnpFSGMKLVGGPTK 155
Cdd:PRK14293  85 -GGFADIFETFFSG---FGGAGGQGGRRR 109
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 48-99 7.00e-16

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 69.04  E-value: 7.00e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767968135   48 HSTAEDKD--QRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYD 99
Cdd:pfam00226   9 SPDASDEEikKAYRKLALKYHPDKnPGDPEAEEKFKEINEAYEVLSDPEKRAIYD 63
PRK14294 PRK14294
chaperone protein DnaJ; Provisional
 49-108 2.07e-15

chaperone protein DnaJ; Provisional


Pssm-ID: 237664 [Multi-domain]  Cd Length: 366  Bit Score: 73.65  E-value: 2.07e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968135  49 STAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG 108
Cdd:PRK14294  16 ASEEEIKKSYRKLAMKYHPDRNpGDKEAEELFKEAAEAYEVLSDPKKRGIYDQYGHEGLSG 76
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 47-152 6.23e-15

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 71.89  E-value: 6.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  47 EHSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlefGSQTPWTTGYVF 126
Cdd:PRK14299  14 KNASQDEIKKAFKKLARKYHPDVNKSPGAEEKFKEINEAYTVLSDPEKRRIYDTYGTTAASAGWQ---GPPPGPPGGGDF 90

                         90       100
                 ....*....|....*....|....*.
gi 767968135 127 HGKPEKVFHEFFggNNPFSGMKLVGG 152
Cdd:PRK14299  91 SGFNVGDFSDFF--QQLFGGRGGFGG 114
PRK14292 PRK14292
chaperone protein DnaJ; Provisional
 49-174 1.18e-14

chaperone protein DnaJ; Provisional


Pssm-ID: 237662 [Multi-domain]  Cd Length: 371  Bit Score: 71.46  E-value: 1.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEE---GLKGGIPleFGsqtpwttGYV 125
Cdd:PRK14292  14 ASADEIKSAYRKLALKYHPDRNKEKGAAEKFAQINEAYAVLSDAEKRAHYDRFGTApgaGMPGGDP--FG-------GMG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767968135 126 FhgKPEKVFHEFFGGnnpfsGMKLVGGPTKAAAEKPSVSTTVPTSSRQS 174
Cdd:PRK14292  85 F--DPMDIFEQLFGG-----AGFGGGRGRRGPARGDDLETEARITLEQA 126
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 50-108 2.51e-14

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 70.62  E-value: 2.51e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968135  50 TAEDKD--QRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG 108
Cdd:PRK14283  16 NADKKEikKAYRKLARKYHPDVSEEEGAEEKFKEISEAYAVLSDDEKRQRYDQFGHAGMDG 76
PRK14286 PRK14286
chaperone protein DnaJ; Provisional
 58-140 8.19e-14

chaperone protein DnaJ; Provisional


Pssm-ID: 172774 [Multi-domain]  Cd Length: 372  Bit Score: 69.25  E-value: 8.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  58 YRRLALKHHPLKSN-EPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPlEFGsQTPWTTGYVFHGKPEKVFHE 136
Cdd:PRK14286  25 YRKLAIKYHPDKNKgNKESEEKFKEATEAYEILRDPKKRQAYDQFGKAGVNAGAG-GFG-QGAYTDFSDIFGDFGDIFGD 102


                 ....
gi 767968135 137 FFGG 140
Cdd:PRK14286 103 FFGG 106
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 48-141 3.02e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 67.65  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  48 HSTAEDKDQRYRRLALKHHP--LKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiplefGSQTPWTTgYV 125
Cdd:PRK14290  14 NASQEDIKKAFRELAKKWHPdlHPGNKAEAEEKFKEISEAYEVLSDPQKRRQYDQTGTVDFGAG-----GSNFNWDN-FT 87

                         90
                 ....*....|....*.
gi 767968135 126 FHGKPEKVFHEFFGGN 141
Cdd:PRK14290  88 HFSDINDIFNQIFGGN 103
PRK14297 PRK14297
molecular chaperone DnaJ;
46-166 3.68e-13

molecular chaperone DnaJ;


Pssm-ID: 184611 [Multi-domain]  Cd Length: 380  Bit Score: 67.50  E-value: 3.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  46 LEHSTAEDKDQR-YRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGipLEFGSQTPWTTG 123
Cdd:PRK14297  12 LEKGASDDEIKKaFRKLAIKYHPDKNkGNKEAEEKFKEINEAYQVLSDPQKKAQYDQFGTADFNGA--GGFGSGGFGGFD 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767968135 124 YVFHGKPEKVFHEFFGGNNPFSGMKLvGGPTKAAAEKPSVSTT 166
Cdd:PRK14297  90 FSDMGGFGDIFDSFFGGGFGSSSRRR-NGPQRGADIEYTINLT 131
PRK14301 PRK14301
chaperone protein DnaJ; Provisional
 49-157 6.64e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 237668 [Multi-domain]  Cd Length: 373  Bit Score: 66.69  E-value: 6.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQR-YRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG-GIPLEFGSqtpwtTGYV 125
Cdd:PRK14301  15 DASEDEIKKaYRKLALQYHPDRNpDNPEAEQKFKEAAEAYEVLRDAEKRARYDRFGHAGVNGnGGFGGFSS-----AEDI 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767968135 126 FhGKPEKVFHEFFGgnnpFSGMKLVGGPTKAA 157
Cdd:PRK14301  90 F-SHFSDIFGDLFG----FSGGGSRRGPRPQA 116
PRK14284 PRK14284
chaperone protein DnaJ; Provisional
 49-160 8.17e-13

chaperone protein DnaJ; Provisional


Pssm-ID: 237658 [Multi-domain]  Cd Length: 391  Bit Score: 66.40  E-value: 8.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEI-FRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLE----FGSQTPWTTG 123
Cdd:PRK14284  13 ASPEEIKKAYRKLAVKYHPDKNPGDAEAEKrFKEVSEAYEVLSDAQKRESYDRYGKDGPFAGAGGFggagMGNMEDALRT 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 767968135 124 YV-----FHGKPEKVFHEFFGGNNPFSGMKLVGGPTKAAAEK 160
Cdd:PRK14284  93 FMgafggEFGGGGSFFEGLFGGLGEAFGMRGGPAGARQGASK 134
DnaJ smart00271
DnaJ molecular chaperone homology domain;
47-94 1.35e-12

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 60.33  E-value: 1.35e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 767968135    47 EHSTAEDKDQRYRRLALKHHP--LKSNEPSSAEIFRQIAEAYDVLSDPMK 94
Cdd:smart00271  11 RDASLDEIKKAYRKLALKYHPdkNPGDKEEAEEKFKEINEAYEVLSDPEK 60
PRK14278 PRK14278
chaperone protein DnaJ; Provisional
 58-140 1.76e-12

chaperone protein DnaJ; Provisional


Pssm-ID: 237654 [Multi-domain]  Cd Length: 378  Bit Score: 65.46  E-value: 1.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDkfgeeglKGGIPLEFGSQTPWTTGYVFHGKPEkVFHEF 137
Cdd:PRK14278  24 YRKLARELHPDVNPDEEAQEKFKEISVAYEVLSDPEKRRIVD-------LGGDPLESAGGGGGGFGGGFGGLGD-VFEAF 95


                 ...
gi 767968135 138 FGG 140
Cdd:PRK14278  96 FGG 98
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 49-157 3.01e-12

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 64.82  E-value: 3.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHP-LKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGL----------------KGGIP 111
Cdd:PRK14277  17 ATEEEIKKAYRRLAKKYHPdLNPGDKEAEQKFKEINEAYEILSDPQKRAQYDQFGHAAFdpggfgqggfgqggfgGGGFD 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 767968135 112 LEFGSqtpwtTGYVFhgkpEKVFHEFFGGnnpfSGMKLVGGPTKAA 157
Cdd:PRK14277  97 FDFGG-----FGDIF----EDIFGDFFGT----GRRRAETGPQKGA 129
PRK14287 PRK14287
chaperone protein DnaJ; Provisional
 47-140 4.31e-12

chaperone protein DnaJ; Provisional


Pssm-ID: 237659 [Multi-domain]  Cd Length: 371  Bit Score: 64.26  E-value: 4.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  47 EHSTAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGE----EGLKGGIPLEFGsqtpwtt 122
Cdd:PRK14287  14 RNASVDEVKKAYRKLARKYHPDVNKAPDAEDKFKEVKEAYDTLSDPQKKAHYDQFGHtdpnQGFGGGGAGDFG------- 86

                         90
                 ....*....|....*...
gi 767968135 123 GYvfhgkpEKVFHEFFGG 140
Cdd:PRK14287  87 GF------SDIFDMFFGG 98
PRK14289 PRK14289
molecular chaperone DnaJ;
49-108 8.86e-12

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 63.31  E-value: 8.86e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968135  49 STAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG 108
Cdd:PRK14289  17 ATVDEIKKAYRKKAIQYHPDKNpGDKEAEEKFKEAAEAYDVLSDPDKRSRYDQFGHAGVGG 77
PRK14295 PRK14295
molecular chaperone DnaJ;
49-140 1.26e-11

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 62.94  E-value: 1.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHP-LKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDK----FGEEGLK--------GGIPLE-- 113
Cdd:PRK14295  21 ATEAEIKKAYRKLAREYHPdANKGDAKAEERFKEISEAYDVLSDEKKRKEYDEarslFGNGGFRpgpgggggGGFNFDlg 100

                         90       100
                 ....*....|....*....|....*....
gi 767968135 114 --FGSQTPWTTGYVFHGKPEKVFHEFFGG 140
Cdd:PRK14295 101 dlFGGGAQGGGGAGGGGGLGDVFGGLFNR 129
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
50-121 1.48e-11

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 58.58  E-value: 1.48e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767968135  50 TAEDKDQRYRRLALKHHPLKSNEP--SSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWT 121
Cdd:COG2214   18 SLEEIRQAYRRLAKLLHPDRGGELkaLAEELFQRLNEAYEVLSDPERRAEYDRELGQSGKGSASQPSAAAQRLA 91
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 47-91 1.72e-10

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 54.47  E-value: 1.72e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767968135  47 EHSTAEDKDQRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSD 91
Cdd:cd06257   10 PDASDEEIKKAYRKLALKYHPDKnPDDPEAEEKFKEINEAYEVLSD 55
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
 49-137 1.96e-10

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 59.42  E-value: 1.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLK--SNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGlkGGIPlefgSQTPWTTGYVF 126
Cdd:PRK14282  16 ATQEEIKRAYKRLVKEWHPDRhpENRKEAEQKFKEIQEAYEVLSDPQKRAMYDRFGYVG--EQPP----YQETESGGGFF 89

                         90
                 ....*....|.
gi 767968135 127 hgkpEKVFHEF 137
Cdd:PRK14282  90 ----EDIFKDF 96
PRK14281 PRK14281
chaperone protein DnaJ; Provisional
 49-146 2.00e-10

chaperone protein DnaJ; Provisional


Pssm-ID: 237657 [Multi-domain]  Cd Length: 397  Bit Score: 59.44  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQ---RYRRLALKHHPLKSNEPSSAE-IFRQIAEAYDVLSDPMKRGIYDKFGEEGLkgGIPLEFGSQTPWTTGY 124
Cdd:PRK14281  12 SRSADKDEikkAYRKLALKYHPDKNPDNKEAEeHFKEVNEAYEVLSNDDKRRRYDQFGHAGV--GSSAASGGGPGYGGGG 89

                         90       100
                 ....*....|....*....|..
gi 767968135 125 VFHGKPEKVFHEFFGGNNPFSG 146
Cdd:PRK14281  90 GDFNDIFSAFNDMFGGGARRGG 111
PRK14288 PRK14288
molecular chaperone DnaJ;
47-106 3.95e-10

molecular chaperone DnaJ;


Pssm-ID: 172776 [Multi-domain]  Cd Length: 369  Bit Score: 58.55  E-value: 3.95e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968135  47 EHSTAEDKDQRYRRLALKHHPLK-SNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGL 106
Cdd:PRK14288  13 KHSNQETIKKSYRKLALKYHPDRnAGDKEAEEKFKLINEAYGVLSDEKKRALYDRYGKKGL 73
PRK14285 PRK14285
chaperone protein DnaJ; Provisional
 58-141 4.97e-10

chaperone protein DnaJ; Provisional


Pssm-ID: 172773 [Multi-domain]  Cd Length: 365  Bit Score: 58.08  E-value: 4.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  58 YRRLALKHHPLKSNEPSSAE-IFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGiplefGSQTPWTTGY-----VFHGKPE 131
Cdd:PRK14285  24 YRKIAIKYHPDKNKGNKEAEsIFKEATEAYEVLIDDNKRAQYDRFGHTAFEGG-----GGFEGFSGGFsgfsdIFEDFGD 98

                         90
                 ....*....|
gi 767968135 132 kVFHEFFGGN 141
Cdd:PRK14285  99 -IFDSFFTGN 107
PRK14279 PRK14279
molecular chaperone DnaJ;
48-116 7.18e-10

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 57.82  E-value: 7.18e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  48 HSTAEDKDQRYRRLALKHHPLKS-NEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGS 116
Cdd:PRK14279  20 DASAEEIKKAYRKLARELHPDANpGDPAAEERFKAVSEAHDVLSDPAKRKEYDETRRLFAGGGFGGRRFD 89
PRK10266 PRK10266
curved DNA-binding protein;
58-100 1.11e-09

curved DNA-binding protein;


Pssm-ID: 182347 [Multi-domain]  Cd Length: 306  Bit Score: 56.75  E-value: 1.11e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767968135  58 YRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDK 100
Cdd:PRK10266  25 YRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQ 67
PRK14296 PRK14296
chaperone protein DnaJ; Provisional
 49-141 7.79e-09

chaperone protein DnaJ; Provisional


Pssm-ID: 237666 [Multi-domain]  Cd Length: 372  Bit Score: 54.57  E-value: 7.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG--GIPLEFGSQTPWTTGYVF 126
Cdd:PRK14296  16 ASEQEIRQAYRKLAKQYHPDLNKSPDAHDKMVEINEAADVLLDKDKRKQYDQFGHAAFDGssGFSSNFGDFEDLFSNMGS 95

                         90
                 ....*....|....*..
gi 767968135 127 HGKPE--KVFHEFFGGN 141
Cdd:PRK14296  96 SGFSSftNIFSDFFGSN 112
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
 37-108 1.60e-08

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 54.02  E-value: 1.60e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767968135   37 LLDRGVNIHLEHSTaedkdQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKG 108
Cdd:PTZ00341  578 ILGVGVNADMKEIS-----ERYFKLAENYYPPKRSGNEGFHKFKKINEAYQILGDIDKKKMYNKFGYDGIKG 644
PRK14300 PRK14300
chaperone protein DnaJ; Provisional
 49-138 2.56e-07

chaperone protein DnaJ; Provisional


Pssm-ID: 172788 [Multi-domain]  Cd Length: 372  Bit Score: 50.01  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968135  49 STAEDKDQRYRRLALKHHPLKSNEPSSAEIFRQIAEAYDVLSDPMKRGIYDKFGEEGLKGGIPLEFGSQTPWttgyvFHG 128
Cdd:PRK14300  15 ASQADLKKAYLKLAKQYHPDTTDAKDAEKKFKEINAAYDVLKDEQKRAAYDRFGHDAFQNQQSRGGGGNHGG-----FHP 89

                         90
                 ....*....|
gi 767968135 129 KPEKVFHEFF 138
Cdd:PRK14300  90 DINDIFGDFF 99
DjlA COG1076
DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];
55-97 1.06e-03

DnaJ domain-containing protein [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440694 [Multi-domain]  Cd Length: 75  Bit Score: 36.70  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767968135  55 DQRYRRLALKHHP--LKSNEPSSA-----EIFRQIAEAYDVLSDPmkRGI 97
Cdd:COG1076   22 KRAYRKLQREHHPdrLAAGLPEEEqrlalQKAAAINEAYETLKDP--RGI 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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