NCBI Conserved Domain Search

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

172-212

2.42e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

Pssm-ID: 459654 Cd Length: 42 Bit Score: 65.64 E-value: 2.42e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   172 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 212
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

308-345

4.58e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 64.57 E-value: 4.58e-13

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968177   308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

417-459

1.63e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.00 E-value: 1.63e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    417 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 459
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

504-546

1.23e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 60.69 E-value: 1.23e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1267-1304

1.36e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 60.34 E-value: 1.36e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968177  1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1345-1379

1.59e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

Pssm-ID: 238060 Cd Length: 35 Bit Score: 60.30 E-value: 1.59e-11

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968177 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

460-503

3.82e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.15 E-value: 3.82e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1307-1341

4.72e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 4.72e-11

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968177 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

719-761

6.48e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.77 E-value: 6.48e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

915-950

9.03e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 58.02 E-value: 9.03e-11

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767968177   915 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 950
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

111-151

2.03e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.03e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

196-238

2.12e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.12e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    196 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

614-649

1.04e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 52.24 E-value: 1.04e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767968177   614 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 649
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

762-805

7.01e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.91 E-value: 7.01e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

34-223

1.04e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.70 E-value: 1.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   34 AAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQ 109
Cdd:COG3391    26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  110 NVVISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER- 187
Cdd:COG3391   104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVi 179

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767968177  188 -AGMDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 223
Cdd:COG3391   180 vSVIDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL super family

cl18310

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

694-887

1.27e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain] Cd Length: 269 Bit Score: 55.02 E-value: 1.27e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  694 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 765
Cdd:cd05819    17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  766 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 836
Cdd:cd05819    96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767968177  837 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 887
Cdd:cd05819   172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

375-415

2.08e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.75 E-value: 2.08e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    375 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 415
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1113-1155

1.01e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.83 E-value: 1.01e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177   1113 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1155
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1226-1262

1.56e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 1.56e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767968177  1226 CARDNGGCSHICIAkGDGTPRCSCPVHLVLLQNLLTC 1262
Cdd:pfam14670    1 CSVNNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

547-580

2.52e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.89 E-value: 2.52e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767968177    547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

979-1018

4.82e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.12 E-value: 4.82e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    979 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1018
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1069-1112

1.89e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.89e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177   1069 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1112
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

239-273

7.67e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 7.67e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767968177    239 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 273
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Name

Accession

Description

Interval

E-value

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

172-212

2.42e-13

Pssm-ID: 459654 Cd Length: 42 Bit Score: 65.64 E-value: 2.42e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   172 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 212
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

308-345

4.58e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 64.57 E-value: 4.58e-13

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968177   308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

417-459

1.63e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.00 E-value: 1.63e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    417 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 459
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

504-546

1.23e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 60.69 E-value: 1.23e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1267-1304

1.36e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 60.34 E-value: 1.36e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968177  1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1345-1379

1.59e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 60.30 E-value: 1.59e-11

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968177 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1268-1304

3.32e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.14 E-value: 3.32e-11

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767968177 1268 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

460-503

3.82e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.15 E-value: 3.82e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1307-1341

4.72e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 4.72e-11

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968177 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

719-761

6.48e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.77 E-value: 6.48e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

152-195

8.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 8.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    152 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 195
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

915-950

9.03e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 58.02 E-value: 9.03e-11

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767968177   915 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 950
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

480-520

1.12e-10

Pssm-ID: 459654 Cd Length: 42 Bit Score: 57.94 E-value: 1.12e-10

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   480 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALD 520
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

111-151

2.03e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.03e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

196-238

2.12e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.12e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    196 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1267-1301

3.21e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.49 E-value: 3.21e-10

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 767968177   1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1301
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1307-1341

1.32e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 54.95 E-value: 1.32e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767968177  1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

130-169

1.83e-09

Pssm-ID: 459654 Cd Length: 42 Bit Score: 54.47 E-value: 1.83e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   130 KLYWTDSET-NRIEVANLNGTSRKVLFWQDLDQPRAIALDP 169
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1345-1376

1.90e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 54.18 E-value: 1.90e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 767968177   1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1376
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1345-1379

6.33e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 53.02 E-value: 6.33e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767968177  1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

614-649

1.04e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 52.24 E-value: 1.04e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767968177   614 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 649
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

437-477

1.24e-08

Pssm-ID: 459654 Cd Length: 42 Bit Score: 52.16 E-value: 1.24e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   437 RNLYWTDTGTD-RIEVTRLNGTSRKILVSEDLDEPRAIALHP 477
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1307-1338

1.59e-08

Pssm-ID: 197566 Cd Length: 33 Bit Score: 51.48 E-value: 1.59e-08

                            10        20        30
                    ....*....|....*....|....*....|..
gi 767968177   1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 1338
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

762-805

7.01e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.91 E-value: 7.01e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

358-571

8.85e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 55.09 E-value: 8.85e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  358 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVAR 437
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  438 NLYWTDTGTDRIEVtrLNGTSRKILVSEDL-DEPRAIALHPVMGLMYWTDWGENpKIecANLDGQERRVLVNASLG-WPN 515
Cdd:COG3391    81 RLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVGaGPH 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968177  516 GLALDLQEGKLYWGDAKTDKI----EVINV-DGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 571
Cdd:COG3391   156 GIAVDPDGKRLYVANSGSNTVsvivSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

34-223

1.04e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.70 E-value: 1.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   34 AAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQ 109
Cdd:COG3391    26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  110 NVVISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER- 187
Cdd:COG3391   104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVi 179

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767968177  188 -AGMDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 223
Cdd:COG3391   180 vSVIDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

694-887

1.27e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 55.02 E-value: 1.27e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  694 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 765
Cdd:cd05819    17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  766 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 836
Cdd:cd05819    96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767968177  837 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 887
Cdd:cd05819   172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

383-544

1.39e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 54.63 E-value: 1.39e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  383 HAIAIDYDpleGYVYWTDDEVRAIRR-----AYLDGSGAQTLVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 457
Cdd:cd05819    58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  458 SRKIL-----VSEDLDEPRAIALHPVmGLMYWTDWGENpKIECANLDGQERRVL-----VNASLGWPNGLALDlQEGKLY 527
Cdd:cd05819   134 FLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH-RIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVD-SDGNIY 210

                         170
                  ....*....|....*..
gi 767968177  528 WGDAKTDKIEVINVDGT 544
Cdd:cd05819   211 VADSGNNRVQVFDPDGA 227

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

657-791

1.43e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.31 E-value: 1.43e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  657 VFTSRAAIHRIS-LETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGlDYPEGMAVD 735
Cdd:COG3391    82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767968177  736 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 791
Cdd:COG3391   161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

375-415

2.08e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.75 E-value: 2.08e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    375 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 415
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1113-1155

1.01e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.83 E-value: 1.01e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177   1113 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1155
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

46-178

1.17e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 51.82 E-value: 1.17e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   46 FANRRDVRLvdAGGVKLESTIVVSGLEDAA--AVDFQfskGAVYWTD-VSEEAIKQtylnQTGAAVQNVV-ISGLVSPDG 121
Cdd:cd14952    70 FGNNRVLKL--AAGSTTQTVLPFTGLNDPTgvAVDAA---GNVYVADtGNNRVLKL----AAGSNTQTVLpFTGLSNPDG 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767968177  122 LACDWVGKkLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTD 178
Cdd:cd14952   141 VAVDGAGN-VYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTD 195

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1226-1262

1.56e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 1.56e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767968177  1226 CARDNGGCSHICIAkGDGTPRCSCPVHLVLLQNLLTC 1262
Cdd:pfam14670    1 CSVNNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

808-847

2.49e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.67 E-value: 2.49e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 767968177    808 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 847
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

C_rich_MXAN6577

NF041328

MXAN_6577-like cysteine-rich domain;

1262-1357

7.73e-06

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 47.44 E-value: 7.73e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177 1262 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSAAQFP---CARGQCVDL----RLRCDGEadCQ 1333
Cdd:NF041328   45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                          90       100
                  ....*....|....*....|....*...
gi 767968177 1334 D-RSDEAD---CDAICLPNQFrCASGQC 1357
Cdd:NF041328  118 DlATDPLHcgaCGVACDPGES-CRGGAC 144

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

394-434

1.75e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 43.30 E-value: 1.75e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   394 GYVYWTDDEVRA-IRRAYLDGSGAQTLVNTEINDPDGIAVDW 434
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

696-736

2.07e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.07e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   696 NHIYWTDVSLK-TISRAFMNGSSVEHVVEFGLDYPEGMAVDW 736
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

721-785

2.50e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.59 E-value: 2.50e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767968177  721 VVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 785
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

740-779

9.56e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.99 E-value: 9.56e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   740 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 779
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

547-580

2.52e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.89 E-value: 2.52e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767968177    547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

727-803

4.10e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 44.20 E-value: 4.10e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  727 DYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQF-RQvlVWR--DLDN----PRSLALDPtKGYIYWTE-WGGkpRIVRA 798
Cdd:cd14956    13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgDGPGqfgrPRGLAVDK-DGWLYVADyWGD--RIQVF 86


                  ....*
gi 767968177  799 FMDGT 803
Cdd:cd14956    87 TLTGE 91

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

979-1018

4.82e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.12 E-value: 4.82e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    979 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1018
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1069-1112

1.89e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.89e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177   1069 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1112
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

782-822

2.74e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 37.14 E-value: 2.74e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   782 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 822
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

524-562

3.02e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.75 E-value: 3.02e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767968177   524 GKLYWGDAKTD-KIEVINVDGTKRRTLLEDKLPHIFGFTL 562
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAV 40

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

216-254

7.41e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 7.41e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767968177   216 QKLYWADAKLSF-IHRANLDGSFRQKVVEGSLTHPFALTL 254
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAV 40

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

239-273

7.67e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 7.67e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767968177    239 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 273
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Name

Accession

Description

Interval

E-value

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

172-212

2.42e-13

Pssm-ID: 459654 Cd Length: 42 Bit Score: 65.64 E-value: 2.42e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   172 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 212
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

308-345

4.58e-13

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 64.57 E-value: 4.58e-13

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968177   308 CEEDNGGCSHLCLLSPSepFYTCACPTGVQLQDNGRTC 345
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

417-459

1.63e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 63.00 E-value: 1.63e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    417 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 459
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

504-546

1.23e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 60.69 E-value: 1.23e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    504 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 546
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1267-1304

1.36e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 60.34 E-value: 1.36e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 767968177  1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1345-1379

1.59e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 60.30 E-value: 1.59e-11

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968177 1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1268-1304

3.32e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.14 E-value: 3.32e-11

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767968177 1268 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1304
Cdd:cd00112     1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

460-503

3.82e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.15 E-value: 3.82e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    460 KILVSEDLDEPRAIALHPVMGLMYWTDWGeNPKIECANLDGQER 503
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1307-1341

4.72e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 4.72e-11

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767968177 1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

719-761

6.48e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.77 E-value: 6.48e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    719 EHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 761
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

152-195

8.78e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 8.78e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    152 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 195
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

915-950

9.03e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 58.02 E-value: 9.03e-11

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767968177   915 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 950
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

480-520

1.12e-10

Pssm-ID: 459654 Cd Length: 42 Bit Score: 57.94 E-value: 1.12e-10

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   480 GLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALD 520
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

111-151

2.03e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.03e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    111 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 151
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

196-238

2.12e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 57.23 E-value: 2.12e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177    196 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 238
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1267-1301

3.21e-10

Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.49 E-value: 3.21e-10

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 767968177   1267 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1301
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1307-1341

1.32e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 54.95 E-value: 1.32e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767968177  1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1341
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

130-169

1.83e-09

Pssm-ID: 459654 Cd Length: 42 Bit Score: 54.47 E-value: 1.83e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   130 KLYWTDSET-NRIEVANLNGTSRKVLFWQDLDQPRAIALDP 169
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1345-1376

1.90e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 54.18 E-value: 1.90e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 767968177   1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1376
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1345-1379

6.33e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 53.02 E-value: 6.33e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 767968177  1345 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1379
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

614-649

1.04e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 52.24 E-value: 1.04e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767968177   614 CADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 649
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

437-477

1.24e-08

Pssm-ID: 459654 Cd Length: 42 Bit Score: 52.16 E-value: 1.24e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   437 RNLYWTDTGTD-RIEVTRLNGTSRKILVSEDLDEPRAIALHP 477
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1307-1338

1.59e-08

Pssm-ID: 197566 Cd Length: 33 Bit Score: 51.48 E-value: 1.59e-08

                            10        20        30
                    ....*....|....*....|....*....|..
gi 767968177   1307 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 1338
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

762-805

7.01e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.91 E-value: 7.01e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    762 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 805
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

358-571

8.85e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 55.09 E-value: 8.85e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  358 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVAR 437
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  438 NLYWTDTGTDRIEVtrLNGTSRKILVSEDL-DEPRAIALHPVMGLMYWTDWGENpKIecANLDGQERRVLVNASLG-WPN 515
Cdd:COG3391    81 RLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVGaGPH 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968177  516 GLALDLQEGKLYWGDAKTDKI----EVINV-DGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 571
Cdd:COG3391   156 GIAVDPDGKRLYVANSGSNTVsvivSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

34-223

1.04e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.70 E-value: 1.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   34 AAQYFPASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQ 109
Cdd:COG3391    26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  110 NVVISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER- 187
Cdd:COG3391   104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVi 179

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 767968177  188 -AGMDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 223
Cdd:COG3391   180 vSVIDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

694-887

1.27e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 55.02 E-value: 1.27e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  694 SNNHIYWTDVSLKTISR-----AFMNGSSVEHVVEFGLDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV--- 765
Cdd:cd05819    17 SSGNIYVADTGNNRIQVfdpdgNFITSFGSFGSGDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFGgsg 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  766 --WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLDTNM 836
Cdd:cd05819    96 dgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTGNHR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767968177  837 IE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 887
Cdd:cd05819   172 IQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

383-544

1.39e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 54.63 E-value: 1.39e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  383 HAIAIDYDpleGYVYWTDDEVRAIRR-----AYLDGSGAQTLVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 457
Cdd:cd05819    58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  458 SRKIL-----VSEDLDEPRAIALHPVmGLMYWTDWGENpKIECANLDGQERRVL-----VNASLGWPNGLALDlQEGKLY 527
Cdd:cd05819   134 FLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH-RIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVD-SDGNIY 210

                         170
                  ....*....|....*..
gi 767968177  528 WGDAKTDKIEVINVDGT 544
Cdd:cd05819   211 VADSGNNRVQVFDPDGA 227

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

657-791

1.43e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.31 E-value: 1.43e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  657 VFTSRAAIHRIS-LETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGlDYPEGMAVD 735
Cdd:COG3391    82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767968177  736 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 791
Cdd:COG3391   161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

375-415

2.08e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.75 E-value: 2.08e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    375 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 415
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1113-1155

1.01e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.83 E-value: 1.01e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 767968177   1113 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1155
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

46-178

1.17e-06

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 51.82 E-value: 1.17e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   46 FANRRDVRLvdAGGVKLESTIVVSGLEDAA--AVDFQfskGAVYWTD-VSEEAIKQtylnQTGAAVQNVV-ISGLVSPDG 121
Cdd:cd14952    70 FGNNRVLKL--AAGSTTQTVLPFTGLNDPTgvAVDAA---GNVYVADtGNNRVLKL----AAGSNTQTVLpFTGLSNPDG 140

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767968177  122 LACDWVGKkLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTD 178
Cdd:cd14952   141 VAVDGAGN-VYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTD 195

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1226-1262

1.56e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.08 E-value: 1.56e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767968177  1226 CARDNGGCSHICIAkGDGTPRCSCPVHLVLLQNLLTC 1262
Cdd:pfam14670    1 CSVNNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

808-847

2.49e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.67 E-value: 2.49e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 767968177    808 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 847
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

346-543

3.95e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 50.08 E-value: 3.95e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  346 KAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTL--VNTE 423
Cdd:COG3391    19 AALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVsvIDLA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  424 IN----------DPDGIAVDWVARNLYWTDTGTDRieVTRLNGTSRKILVSEDL-DEPRAIALHPVMGLMYWTDWGENpK 492
Cdd:COG3391    99 TGkvvatipvggGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSN-T 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767968177  493 IEC--ANLDGQERRVLVNASLG-WPNGLALDLQEGKLY-------WGDAKTDKIEVINVDG 543
Cdd:COG3391   176 VSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYvanrgsnTSNGGSNTVSVIDLAT 236

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

678-718

5.19e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 44.90 E-value: 5.19e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    678 IPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSV 718
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

385-543

6.77e-06

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 49.51 E-value: 6.77e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  385 IAIDYDPlEGYVYWTDDEVRAIRRAYLDGSGAQTLVNT-EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILV 463
Cdd:cd14962    60 IGVAIDA-NGNLYVSDAELGKVFVFDRDGKFLRAIGAGaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  464 S-----EDLDEPRAIALHPvMGLMYWTDWGeNPKIECANLDGQERRV-----LVNASLGWPNGLALDlQEGKLYWGDAKT 533
Cdd:cd14962   139 KrgsgpGEFNLPTDLAVDR-DGNLYVTDTM-NFRVQIFDADGKFLRSfgergDGPGSFARPKGIAVD-SEGNIYVVDAAF 215

                         170
                  ....*....|
gi 767968177  534 DKIEVINVDG 543
Cdd:cd14962   216 DNVQIFNPEG 225

C_rich_MXAN6577

NF041328

MXAN_6577-like cysteine-rich domain;

1262-1357

7.73e-06

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 47.44 E-value: 7.73e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177 1262 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSAAQFP---CARGQCVDL----RLRCDGEadCQ 1333
Cdd:NF041328   45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                          90       100
                  ....*....|....*....|....*...
gi 767968177 1334 D-RSDEAD---CDAICLPNQFrCASGQC 1357
Cdd:NF041328  118 DlATDPLHcgaCGVACDPGES-CRGGAC 144

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

847-888

9.00e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 44.13 E-value: 9.00e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177    847 RVVIADDLPHPFGLT--QYSDYIYWTDWNLHSIERADKTsGRNR 888
Cdd:smart00135    1 RTLLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

394-434

1.75e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 43.30 E-value: 1.75e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   394 GYVYWTDDEVRA-IRRAYLDGSGAQTLVNTEINDPDGIAVDW 434
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

425-548

1.94e-05

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 48.06 E-value: 1.94e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  425 NDPDGIAVDWvaRNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDE-----PRAIALHPvMGLMYWTDWGeNPKIECANLD 499
Cdd:cd14963    10 NKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLY-NGRIQVFDPD 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767968177  500 GQERRVLVNAS----LGWPNGLALDlqEGKLYWGDAKTDKIEVINVDGTKRRT 548
Cdd:cd14963    86 GKFLKYFPEKKdrvkLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE 136

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

696-736

2.07e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.07e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   696 NHIYWTDVSLK-TISRAFMNGSSVEHVVEFGLDYPEGMAVDW 736
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

721-785

2.50e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.59 E-value: 2.50e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767968177  721 VVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 785
Cdd:cd14952     3 VLPFtGLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

738-837

2.57e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 47.38 E-value: 2.57e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  738 GKNLYWADTGTNRIEVARLDgQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKpRIVRafMDGTNcMTLVDKV---GR 814
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RVSV--IDTAT-GKVVATIpvgAG 153

                          90       100
                  ....*....|....*....|...
gi 767968177  815 ANDLTIDYADQRLYWTDLDTNMI 837
Cdd:COG3391   154 PHGIAVDPDGKRLYVANSGSNTV 176

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

692-837

3.15e-05

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 47.67 E-value: 3.15e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  692 DVSNNHIYWTDVSLKTISRAFMNGssvEHVVEFG--------LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFRQV 763
Cdd:cd14963   108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  764 LVWRDLD-----NPRSLALDPtKGYIY-----------WTEWGGKPRIVRAFMDGTNCMTLvdkvgrANDLTIDyADQRL 827
Cdd:cd14963   184 LNGSPDGksgfvNPRGIAVDP-DGNLYvvdnlshrvyvFDEQGKELFTFGGRGKDDGQFNL------PNGLFID-DDGRL 255

                         170
                  ....*....|
gi 767968177  828 YWTDLDTNMI 837
Cdd:cd14963   256 YVTDRENNRV 265

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

663-837

3.86e-05

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 47.32 E-value: 3.86e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  663 AIHRISLETNNND-VAIPlTGVKEASALDFDvSNNHIYWTDVSLKTISR---AfmNGSSVEHVVEFGLDYPEGMAVDWMG 738
Cdd:COG4257    81 RIGRIDPKTGEITtFALP-GGGSNPHGIAFD-PDGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  739 kNLYWADTGTNRIevARLD---GQFRQVLVWRDLDNPRSLALDPtKGYIYWTEWGGkpRIVRAFMDGTNCMT---LVDKV 812
Cdd:COG4257   157 -NLWVTDFGANAI--GRIDpdtGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGS--GRIGRFDPKTGTVTeypLPGGG 230

                         170       180
                  ....*....|....*....|....*
gi 767968177  813 GRANDLTIDYADqRLYWTDLDTNMI 837
Cdd:COG4257   231 ARPYGVAVDGDG-RVWFAESGANRI 254

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

673-797

3.93e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 46.82 E-value: 3.93e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  673 NNDVAIPLTGVKEASALDFDVSNNhIYWTD------VSLKTisrafmnGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWAD 745
Cdd:cd14952    83 TTQTVLPFTGLNDPTGVAVDAAGN-VYVADtgnnrvLKLAA-------GSNTQTVLPFtGLSNPDGVAVDGAG-NVYVTD 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767968177  746 TGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDpTKGYIYWTEwGGKPRIVR 797
Cdd:cd14952   154 TGNNR--VLKLAaGSTTQtVLPFTGLNSPSGVAVD-TAGNVYVTD-HGNNRVLK 203

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

416-577

3.94e-05

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 47.29 E-value: 3.94e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  416 AQTLVNTEINDPDGIAVDwvARNLYWTDTGTDRIEVTRLNGTSRKILVSE-----DLDEPRAIALHPvMGLMYWTDWGeN 490
Cdd:cd14963    93 PEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgsepgELSYPNGIAVDE-DGNIYVADSG-N 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  491 PKIECANLDGQERRVLVNASLGW-----PNGLALDlQEGKLYWGDAKTDKIEVINVDGTKRRTL----LED---KLPHif 558
Cdd:cd14963   169 GRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVD-PDGNLYVVDNLSHRVYVFDEQGKELFTFggrgKDDgqfNLPN-- 245

                         170       180
                  ....*....|....*....|
gi 767968177  559 GFTLLGD-FIYWTDWQRRSI 577
Cdd:cd14963   246 GLFIDDDgRLYVTDRENNRV 265

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

740-779

9.56e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.99 E-value: 9.56e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 767968177   740 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 779
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

385-544

1.05e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 46.12 E-value: 1.05e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  385 IAIDYDpleGYVYWTDDEVRAIRRAYLDGSGAQTL-----VNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT-- 457
Cdd:cd14956    65 LAVDKD---GWLYVADYWGDRIQVFTLTGELQTIGgssgsGPGQFNAPRGVAVD-ADGNLYVADFGNQRIQKFDPDGSfl 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  458 ----SRKILVSEdLDEPRAIALHPVmGLMYWTDwGENPKIECANLDGQERRVL--VNASLGW---PNGLALDlQEGKLYW 528
Cdd:cd14956   141 rqwgGTGIEPGS-FNYPRGVAVDPD-GTLYVAD-TYNDRIQVFDNDGAFLRKWggRGTGPGQfnyPYGIAID-PDGNVFV 216

                         170
                  ....*....|....*.
gi 767968177  529 GDAKTDKIEVINVDGT 544
Cdd:cd14956   217 ADFGNNRIQKFTADGT 232

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

44-180

1.26e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 45.46 E-value: 1.26e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   44 LLFANRRD--VRLVDAGGVKLESTIVVSGleDAAAVDFQFSKGAVYWTDVSEEAIkQTYLNQTGAAVQnvVISGLVSPDG 121
Cdd:COG3391    82 LYVANSGSgrVSVIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRV-SVIDTATGKVVA--TIPVGAGPHG 156

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767968177  122 LACDWVGKKLYWTDSETNRIE--VANLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWG 180
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRG 218

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

727-879

1.89e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 44.97 E-value: 1.89e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  727 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVWRD-------LDNPRSLALDPtKGYIYWTEwGGKPRIVRAF 799
Cdd:cd14956   107 NAPRGVAVDADG-NLYVADFGNQRIQKFDPDGSF--LRQWGGtgiepgsFNYPRGVAVDP-DGTLYVAD-TYNDRIQVFD 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  800 MDGtncmTLVDKVGR----------ANDLTIDyADQRLYWTDLDTNMIESSNMLGQERVVI--ADDLPHPF----GLTQY 863
Cdd:cd14956   182 NDG----AFLRKWGGrgtgpgqfnyPYGIAID-PDGNVFVADFGNNRIQKFTADGTFLTSWgsPGTGPGQFknpwGVVVD 256

                         170
                  ....*....|....*..
gi 767968177  864 SD-YIYWTDWNLHSIER 879
Cdd:cd14956   257 ADgTVYVADSNNNRVQR 273

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

389-549

2.47e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.88 E-value: 2.47e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  389 YDPlEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEiNDPDGIAVD-----WVARN---LYWTDTGTDRIEV--------- 451
Cdd:COG3386    15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTVladeygkpl 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  452 TRLN------------------------------GTSRKILvsEDLDEPRAIALHPVMGLMYWTDWGENpKIECANLDGQ 501
Cdd:COG3386    93 NRPNdgvvdpdgrlyftdmgeylptgalyrvdpdGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAG-RIYRFDLDAD 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767968177  502 ----ERRVLVNASL--GWPNGLALDlQEGKLYWGDAKTDKIEVINVDGTKRRTL 549
Cdd:COG3386   170 gtlgNRRVFADLPDgpGGPDGLAVD-ADGNLWVALWGGGGVVRFDPDGELLGRI 222

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

547-580

2.52e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.89 E-value: 2.52e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 767968177    547 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 580
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

421-797

2.62e-04

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 44.62 E-value: 2.62e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  421 NTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTsrkilvsedldepraialhpvmglmYWTDWGENpkiecANLDG 500
Cdd:cd05819     4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDGN-------------------------FITSFGSF-----GSGDG 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  501 QerrvlvnasLGWPNGLALDlQEGKLYWGDAKTDKIEVINVDGTKRRTLledklpHIFGFTLLGDF------------IY 568
Cdd:cd05819    53 Q---------FNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASF------GGSGDGDGEFNgprgiavdssgnIY 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  569 WTDWQRRsieRVHKVKASRDVIidqlpdlmglkavnvaKVVGTNpcadrNGGCSHLCFftphatrcgcPIGLellsdmkt 648
Cdd:cd05819   117 VADTGNH---RIQKFDPDGEFL----------------TTFGSG-----GSGPGQFNG----------PTGV-------- 154

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  649 civpeaflvftsraAIHRisletnNNDVAIpltgvkeasaLDFDvsNNHIYWTDVSLKTISRAfmnGSSVEHVVEFglDY 728
Cdd:cd05819   155 --------------AVDS------DGNIYV----------ADTG--NHRIQVFDPDGNFLTTF---GSTGTGPGQF--NY 197

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767968177  729 PEGMAVDWMGkNLYWADTGTNRIEVARLDGQFRQVL-----VWRDLDNPRSLALDPtKGYIYWTEWGGkPRIVR 797
Cdd:cd05819   198 PTGIAVDSDG-NIYVADSGNNRVQVFDPDGAGFGGNgnflgSDGQFNRPSGLAVDS-DGNLYVADTGN-NRIQV 268

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

721-833

3.06e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.50 E-value: 3.06e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  721 VVEFGLDYPEGMAVDWMGkNLYWADTGTNRIevARLDGQFRQVLVWRDLDN-PRSLALDPtKGYIYWTEwgGKPRIVRAF 799
Cdd:COG3386     2 LADAGFRLGEGPVWDPDG-RLYWVDIPGGRI--HRYDPDGGAVEVFAEPSGrPNGLAFDP-DGRLLVAD--HGRGLVRFD 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767968177  800 MDGTNCMTLVDKVG----RANDLTIDyADQRLYWTDLD 833
Cdd:COG3386    76 PADGEVTVLADEYGkplnRPNDGVVD-PDGRLYFTDMG 112

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

84-273

3.11e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.50 E-value: 3.11e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   84 GAVYWTDVSEEAIkQTYLNQTGAAVQNVVISGLVS-----PDG--LACDwVGKKLYWTDSETNRIEV-ANLNGTsrkvlf 155
Cdd:COG3386    19 GRLYWVDIPGGRI-HRYDPDGGAVEVFAEPSGRPNglafdPDGrlLVAD-HGRGLVRFDPADGEVTVlADEYGK------ 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  156 wqDLDQPRAIALDPaHGYMYWTD---WGETPRIERAGMDGSTRkiIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRAN 232
Cdd:COG3386    91 --PLNRPNDGVVDP-DGRLYFTDmgeYLPTGALYRVDPDGSLR--VLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFD 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767968177  233 LDGSfrqkvveGSLTHP--FALTLSGD------------TLYWTDWQTRSIHACN 273
Cdd:COG3386   166 LDAD-------GTLGNRrvFADLPDGPggpdglavdadgNLWVALWGGGGVVRFD 213

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

715-779

3.51e-04

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 44.12 E-value: 3.51e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767968177  715 GSSVEHVVEF-GLDYPEGMAVDWMGkNLYWADTGTNRieVARLDGQ--FRQVLVWRDLDNPRSLALDP 779
Cdd:cd14952    81 GSTTQTVLPFtGLNDPTGVAVDAAG-NVYVADTGNNR--VLKLAAGsnTQTVLPFTGLSNPDGVAVDG 145

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

76-298

3.95e-04

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 44.23 E-value: 3.95e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177   76 AVDfqfSKGAVYWTDVSEEAIKQtyLNQTGAAVQNVVISG-----LVSPDGLACDwVGKKLYWTDSETNRIEVANLNGTS 150
Cdd:cd05819    14 AVD---SSGNIYVADTGNNRIQV--FDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  151 RKV-----LFWQDLDQPRAIALDPAhGYMYWTDWGETpRIERAGMDGSTRKII-----VDSDIYWPNGLTIDlEEQKLYW 220
Cdd:cd05819    88 LASfggsgDGDGEFNGPRGIAVDSS-GNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  221 ADAKLSFIHRANLDGSF-----RQKVVEGSLTHPFALTLSGD-TLYWTDWQTRSIH-----ACNKRTGGKRKEILSALYS 289
Cdd:cd05819   165 ADTGNHRIQVFDPDGNFlttfgSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQvfdpdGAGFGGNGNFLGSDGQFNR 244


                  ....*....
gi 767968177  290 PMDIQVLSQ 298
Cdd:cd05819   245 PSGLAVDSD 253

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

727-803

4.10e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 44.20 E-value: 4.10e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  727 DYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQF-RQvlVWR--DLDN----PRSLALDPtKGYIYWTE-WGGkpRIVRA 798
Cdd:cd14956    13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgDGPGqfgrPRGLAVDK-DGWLYVADyWGD--RIQVF 86


                  ....*
gi 767968177  799 FMDGT 803
Cdd:cd14956    87 TLTGE 91

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

423-539

4.27e-04

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.82 E-value: 4.27e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  423 EINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDE-----PRAIALHPvMGLMYWTDWGENpKIECAN 497
Cdd:cd14963   146 ELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVDP-DGNLYVVDNLSH-RVYVFD 222

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767968177  498 LDGQERRVL-----VNASLGWPNGLALDlQEGKLYWGDAKTDKIEVI 539
Cdd:cd14963   223 EQGKELFTFggrgkDDGQFNLPNGLFID-DDGRLYVTDRENNRVAVY 268

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

112-263

4.70e-04

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 43.73 E-value: 4.70e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  112 VISGLVSPDGLACDWVGKkLYWTDSETNRIEVANLNgtSRKVLFW-----QDLDQPRAIALDPAhGYMYWTDwGETPRIE 186
Cdd:cd14962     7 PKEALTRPYGVAADGRGR-IYVADTGRGAVFVFDLP--NGKVFVIgnagpNRFVSPIGVAIDAN-GNLYVSD-AELGKVF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  187 RAGMDGS-TRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSF-----RQKVVEGSLTHPFALTLSGD-TL 259
Cdd:cd14962    82 VFDRDGKfLRAIGAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLlfdigKRGSGPGEFNLPTDLAVDRDgNL 161


                  ....
gi 767968177  260 YWTD 263
Cdd:cd14962   162 YVTD 165

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

979-1018

4.82e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.12 E-value: 4.82e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 767968177    979 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1018
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

672-751

8.04e-04

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.97 E-value: 8.04e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  672 NNNDVAIPLTGVKEASALDFDVSNNhIYWTDVSLKTISRaFMNGSSVEHVVEF-GLDYPEGMAVDWMGkNLYWADTGTNR 750
Cdd:cd14952   166 STTQTVLPFTGLNSPSGVAVDTAGN-VYVTDHGNNRVLK-LAAGSTTPTVLPFtGLNGPLGVAVDAAG-NVYVADRGNDR 242


                  .
gi 767968177  751 I 751
Cdd:cd14952   243 V 243

NHL_like_4

cd14955

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

727-785

8.42e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 43.33 E-value: 8.42e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767968177  727 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVW-------RDLDNPRSLALDPTkGYIY 785
Cdd:cd14955    16 NSPSGIAVDSAG-NVYVADTGNNRIQKFDSTGTF--LTKWgssgsgdGQFYSPTGIAVDSD-GNVY 77

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

383-449

1.34e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.19 E-value: 1.34e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767968177  383 HAIAIDydpLEGYVYWTDDEVRAIRRayLD-GSGAQT-LVNTEINDPDGIAVDwVARNLYWTDTGTDRI 449
Cdd:cd14952   181 SGVAVD---TAGNVYVTDHGNNRVLK--LAaGSTTPTvLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

425-544

1.45e-03

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 42.27 E-value: 1.45e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  425 NDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRKILVS-----EDLDEPRAIALHPvMGLMYWTDwGENPKIECANLD 499
Cdd:cd14956    13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFLRRFGTtgdgpGQFGRPRGLAVDK-DGWLYVAD-YWGDRIQVFTLT 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767968177  500 GQERRVL-----VNASLGWPNGLALDLQeGKLYWGDAKTDKIEVINVDGT 544
Cdd:cd14956    90 GELQTIGgssgsGPGQFNAPRGVAVDAD-GNLYVADFGNQRIQKFDPDGS 138

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

383-490

1.50e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.19 E-value: 1.50e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  383 HAIAIDYDpleGYVYWTD-DEVRAIRRAylDGSGAQT-LVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRK 460
Cdd:cd14952    97 TGVAVDAA---GNVYVADtGNNRVLKLA--AGSNTQTvLPFTGLSNPDGVAVD-GAGNVYVTDTGNNRVLKLAAGSTTQT 170

                          90       100       110
                  ....*....|....*....|....*....|
gi 767968177  461 ILVSEDLDEPRAIALHPVmGLMYWTDWGEN 490
Cdd:cd14952   171 VLPFTGLNSPSGVAVDTA-GNVYVTDHGNN 199

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1069-1112

1.89e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 37.58 E-value: 1.89e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 767968177   1069 VVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1112
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

655-797

2.32e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.80 E-value: 2.32e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  655 FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASA--LDFDvSNNHIYWTDVSLKTISRAFM----NGSSveHVVEFGLDY 728
Cdd:COG3386    62 LLVADHGRGLVRFDPADGEVTVLADEYGKPLNRPndGVVD-PDGRLYFTDMGEYLPTGALYrvdpDGSL--RVLADGLTF 138

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968177  729 PEGMAVDWMGKNLYWADTGTNRIEVARL--DGQFRQVLVWRDLD----NPRSLALDpTKGYIYWTEWGGKpRIVR 797
Cdd:COG3386   139 PNGIAFSPDGRTLYVADTGAGRIYRFDLdaDGTLGNRRVFADLPdgpgGPDGLAVD-ADGNLWVALWGGG-GVVR 211

NHL_like_1

cd14953

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...

408-544

2.43e-03

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 42.13 E-value: 2.43e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  408 RAYLDGSGAqtlVNTEINDPDGIAVDwVARNLYWTDTGTDRI-------EVTRLNGTSR------KILVSEDLDEPRAIA 474
Cdd:cd14953   118 AGFSDDGGA---TAAQFNYPTGVAVD-AAGNLYVADTGNHRIrkitpdgVVTTVAGTGGagyagdGPATAAQFNNPTGVA 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  475 LHPvMGLMYWTDWGeNPKIECANLDGQERRVL-------------VNASLGWPNGLALDlQEGKLYWGDAKTDKIEVINV 541
Cdd:cd14953   194 VDA-AGNLYVADRG-NHRIRKITPDGVVTTVAgtgtagfsgdggaTAAQLNNPTGVAVD-AAGNLYVADSGNHRIRKITP 270


                  ...
gi 767968177  542 DGT 544
Cdd:cd14953   271 AGV 273

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

782-822

2.74e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 37.14 E-value: 2.74e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   782 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 822
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

524-562

3.02e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.75 E-value: 3.02e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767968177   524 GKLYWGDAKTD-KIEVINVDGTKRRTLLEDKLPHIFGFTL 562
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAV 40

NHL_TRIM71_like

cd14954

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...

726-785

3.11e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 41.38 E-value: 3.11e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767968177  726 LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQF-----RQVLVWRDLDNPRSLALDPTkGYIY 785
Cdd:cd14954   117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNPD-GNIV 179

NHL_like_4

cd14955

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

726-803

4.08e-03

Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 41.02 E-value: 4.08e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  726 LDYPEGMAVDWMGkNLYWADTGTNRIE--------VARL------DGQFrqvlvwrdlDNPRSLALDPTkGYIYWTEWGG 791
Cdd:cd14955    62 FYSPTGIAVDSDG-NVYVADTGNHRIQkfdstgtfLTKWgssgsgDGQF---------NSPSGIAVDSA-GNVYVTDSGN 130

                          90
                  ....*....|..
gi 767968177  792 kPRIVRAFMDGT 803
Cdd:cd14955   131 -NRIQKFDSSGT 141

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

117-277

5.26e-03

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 40.77 E-value: 5.26e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  117 VSPDGlacdwvgkKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTDWGETpRIERAGM-DGSTR 195
Cdd:COG4257    24 VDPDG--------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPD-GNLWFTDNGNN-RIGRIDPkTGEIT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  196 KIIVDSDIYWPNGLTIDlEEQKLYWADAKLSFIHRANLD-GSFRQKVVEGSLTHPFALTLSGD-TLYWTDWQTRSIHACN 273
Cdd:COG4257    94 TFALPGGGSNPHGIAFD-PDGNLWFTDQGGNRIGRLDPAtGEVTEFPLPTGGAGPYGIAVDPDgNLWVTDFGANAIGRID 172


                  ....
gi 767968177  274 KRTG 277
Cdd:COG4257   173 PDTG 176

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

865-905

5.74e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 5.74e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 767968177   865 DYIYWTDWNLH-SIERADKTSGRNRTLIQGHLDFVMDILVFH 905
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_2

cd14957

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

377-544

5.79e-03

Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 40.71 E-value: 5.79e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  377 QVDDIRHaIAIDYDpleGYVYWTDDEVRAIR-------RAYLDGSGAQTlvNTEINDPDGIAVDwVARNLYWTDTGTDRI 449
Cdd:cd14957    16 QFNTPRG-IAVDSA---GNIYVADTGNNRIQvftssgvYSYSIGSGGTG--SGQFNSPYGIAVD-SNGNIYVADTDNNRI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968177  450 EV-TRLNGTSRKI----LVSEDLDEPRAIALHPvMGLMYWTDwGENPKIECANLDGQERRVLVNASLGW-----PNGLAL 519
Cdd:cd14957    89 QVfNSSGVYQYSIgtggSGDGQFNGPYGIAVDS-NGNIYVAD-TGNHRIQVFTSSGTFSYSIGSGGTGPgqfngPQGIAV 166

                         170       180
                  ....*....|....*....|....*
gi 767968177  520 DlQEGKLYWGDAKTDKIEVINVDGT 544
Cdd:cd14957   167 D-SDGNIYVADTGNHRIQVFTSSGT 190

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

216-254

7.41e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 7.41e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767968177   216 QKLYWADAKLSF-IHRANLDGSFRQKVVEGSLTHPFALTL 254
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAV 40

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

239-273

7.67e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 7.67e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 767968177    239 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 273
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

NHL_PKND_like