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Conserved domains on  [gi|767968281|ref|XP_011543374|]
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P2X purinoceptor 3 isoform X3 [Homo sapiens]

Protein Classification

P2X purinoceptor( domain architecture ID 10467639)

P2X purinoceptor consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P2X_receptor super family cl02993
ATP P2X receptor;
1-284 1.82e-178

ATP P2X receptor;


The actual alignment was detected with superfamily member TIGR00863:

Pssm-ID: 470714  Cd Length: 372  Bit Score: 498.10  E-value: 1.82e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281    1 MDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEE--KYRCVSDSQC--GPERLPGGGILTGRCVNYSSVLRTCEIQ 76
Cdd:TIGR00863  86 WDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSvpLAICWSDSDCtaGEAGTHGNGIKTGRCVPFNGTVKTCEIF 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281   77 GWCPTEVDTVETPIM-MEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDF 155
Cdd:TIGR00863 166 AWCPVEVDTVPSPPLlKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVEEAGQDF 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281  156 AKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDsvSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLV 235
Cdd:TIGR00863 246 QDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLD--NKEKNVSPGYNFRFAKYYRDNAGVETRTLLKAYGIRFDILV 323
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 767968281  236 YGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 284
Cdd:TIGR00863 324 TGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFMKKRHFYRDKKF 372
 
Name Accession Description Interval E-value
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
1-284 1.82e-178

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 498.10  E-value: 1.82e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281    1 MDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEE--KYRCVSDSQC--GPERLPGGGILTGRCVNYSSVLRTCEIQ 76
Cdd:TIGR00863  86 WDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSvpLAICWSDSDCtaGEAGTHGNGIKTGRCVPFNGTVKTCEIF 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281   77 GWCPTEVDTVETPIM-MEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDF 155
Cdd:TIGR00863 166 AWCPVEVDTVPSPPLlKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVEEAGQDF 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281  156 AKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDsvSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLV 235
Cdd:TIGR00863 246 QDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLD--NKEKNVSPGYNFRFAKYYRDNAGVETRTLLKAYGIRFDILV 323
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 767968281  236 YGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 284
Cdd:TIGR00863 324 TGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFMKKRHFYRDKKF 372
P2X_receptor pfam00864
ATP P2X receptor;
1-286 4.45e-167

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 468.96  E-value: 4.45e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281    1 MDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPES-EEKYRCVSDSQCGPERLP--GGGILTGRCVNYSSVLRTCEIQG 77
Cdd:pfam00864  72 WDVADYVIPPQGENVFFVMTNLIVTPNQTQGTCPESpDGKPNCTSDQDCGAGEGKpvGNGIQTGRCVPFNWTTKTCEIFG 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281   78 WCPTEVDTVE--TPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDF 155
Cdd:pfam00864 152 WCPVELDTAPpfPPLLKNAENFTVFIKNSIRFPKFNFSRRNILPQYDKTYLKTCTYHPLTDPYCPIFRLGDIVAEAGENF 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281  156 AKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLV 235
Cdd:pfam00864 232 SELANKGGVIGIKINWDCDLDSDRSHCNPKYSFRRLDGKNFNNAVSPGYNFRFAKYYKEKNGVERRTLIKAYGIRFDIIV 311
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767968281  236 YGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE 286
Cdd:pfam00864 312 FGKAGKFSIIPTIINIGSGLALLGVATVLCDLILLYFLKKREFYYDKKFEE 362
 
Name Accession Description Interval E-value
P2X TIGR00863
cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC ...
1-284 1.82e-178

cation transporter protein; ATP-gated Cation Channel (ACC) Family (TC 1.A.7)Members of the ACC family (also called P2X receptors) respond to ATP, a functional neurotransmitter released by exocytosis from many types of neurons.These channels, which function at neuron-neuron and neuron-smooth muscle junctions, may play roles in the control of blood pressure and pain sensation. They may also function in lymphocyte and plateletphysiology. They are found only in animals.ACC channels are probably hetero- or homomultimers and transport small monovalent cations (Me+). Some also transport Ca2+; a few also transport small metabolites. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273307  Cd Length: 372  Bit Score: 498.10  E-value: 1.82e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281    1 MDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEE--KYRCVSDSQC--GPERLPGGGILTGRCVNYSSVLRTCEIQ 76
Cdd:TIGR00863  86 WDVADYVKPPQGENVFFVMTNFIVTPNQTQGRCPEHPSvpLAICWSDSDCtaGEAGTHGNGIKTGRCVPFNGTVKTCEIF 165
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281   77 GWCPTEVDTVETPIM-MEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDF 155
Cdd:TIGR00863 166 AWCPVEVDTVPSPPLlKEAENFTLFIKNSIRFPKFNFSKRNILETWDATYLKTCLFDPDSDPYCPIFRLGDIVEEAGQDF 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281  156 AKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDsvSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLV 235
Cdd:TIGR00863 246 QDLALKGGVVGITINWDCDLDKAASHCNPKYSFRRLD--NKEKNVSPGYNFRFAKYYRDNAGVETRTLLKAYGIRFDILV 323
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 767968281  236 YGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKF 284
Cdd:TIGR00863 324 TGKAGKFDIIPTMITIGSGLASLGVGTFLCDLILLYFMKKRHFYRDKKF 372
P2X_receptor pfam00864
ATP P2X receptor;
1-286 4.45e-167

ATP P2X receptor;


Pssm-ID: 459968  Cd Length: 362  Bit Score: 468.96  E-value: 4.45e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281    1 MDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPES-EEKYRCVSDSQCGPERLP--GGGILTGRCVNYSSVLRTCEIQG 77
Cdd:pfam00864  72 WDVADYVIPPQGENVFFVMTNLIVTPNQTQGTCPESpDGKPNCTSDQDCGAGEGKpvGNGIQTGRCVPFNWTTKTCEIFG 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281   78 WCPTEVDTVE--TPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDF 155
Cdd:pfam00864 152 WCPVELDTAPpfPPLLKNAENFTVFIKNSIRFPKFNFSRRNILPQYDKTYLKTCTYHPLTDPYCPIFRLGDIVAEAGENF 231
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767968281  156 AKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLV 235
Cdd:pfam00864 232 SELANKGGVIGIKINWDCDLDSDRSHCNPKYSFRRLDGKNFNNAVSPGYNFRFAKYYKEKNGVERRTLIKAYGIRFDIIV 311
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767968281  236 YGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE 286
Cdd:pfam00864 312 FGKAGKFSIIPTIINIGSGLALLGVATVLCDLILLYFLKKREFYYDKKFEE 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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