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Conserved domains on  [gi|767988365|ref|XP_011544077|]
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katanin-interacting protein isoform X4 [Homo sapiens]

Protein Classification

KATNIP family protein( domain architecture ID 10384633)

KATNIP family protein is a DUF4457 domain-containing protein; similar to Homo sapiens katanin-interacting protein (KATNIP, also known as KIAA0556), which is a ciliary basal body component, and may influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 1235-1554 0e+00

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 611.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1235 LNFTASWGDLHYLGLTGLEVVGKEGQALPIHLHQISASPRDLNELPEYSDDSRALDKLIDGTNITMEDEHMWLIPFSPGL 1314
Cdd:pfam14652    1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIPIQLSNITASPRDLNDLPGYSGDYRTLDKLIDGTNVTTDDEHMWLIPFSPGK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1315 DHVVTIRLDRAESIAGLRFWNYNKSPEDTYRGAKIVHVSLDGLCVSPPEGFLIRKGPGNCHFDFAQEILF--VDYLRAQL 1392
Cdd:pfam14652   81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPEGFLLRKAPGNCHFDFAQTISFpnVDKVNPPS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1393 LPQPAR-RLDMRSLECASMDYEAPLMPCGFIFQFQLLTSWGDPYYIGLTGLELYDERGEKIPLSENNIAAFPDSVNSLEG 1471
Cdd:pfam14652  161 KQSESQlRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1472 VGGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYAKTPHRGVKEFGLLVDDLLVYNGIL 1551
Cdd:pfam14652  241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNGIL 320


                   ...
gi 767988365  1552 AMV 1554
Cdd:pfam14652  321 RKA 323
DUF4457 super family cl20613
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 986-1130 1.06e-35

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


The actual alignment was detected with superfamily member pfam14652:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 138.95  E-value: 1.06e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   986 DFKIPVLPYGQRLVIDIKSTWGDRHYVGLNGIEIFSSKGEPVQI--SNIKADPPDINILPAYGKDPRVVTNLIDGVNRTQ 1063
Cdd:pfam14652  180 DYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLteNNIAAFPDSVNVLDGVSGDVRTPDKLIDGVNNTN 259

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767988365  1064 DDMHVWLAPFTRGRSHSITIDFTHPCHVALIRIWNYNKSrihSFRGVKDITMLLDTQCIFEGEIAKA 1130
Cdd:pfam14652  260 DGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKT---PSRGVKEFAILVDDLLIYNGILRKA 323
DUF4457 super family cl20613
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 503-628 1.52e-03

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


The actual alignment was detected with superfamily member pfam14652:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 42.65  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   503 EILSNWGNSWWVGLTEVEFFDLNDTKLYVS-------PHDVDIRNTA-----TPGELGRLVNRNLAGKkdsSPWTCPFHP 570
Cdd:pfam14652  195 QLLSTWGDPYYIGLNGLELYDENGELIPLTenniaafPDSVNVLDGVsgdvrTPDKLIDGVNNTNDGR---HMWLAPILP 271

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   571 PL-QLFFVIRNTrqlgDFHLAKIKVRNYW-TADGdldiGAKNVKLYVNRNLIFNGKLDKG 628
Cdd:pfam14652  272 GLvNRIYVIFDQ----PITVSMIKIWNYSkTPSR----GVKEFAILVDDLLIYNGILRKA 323
 
Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 1235-1554 0e+00

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 611.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1235 LNFTASWGDLHYLGLTGLEVVGKEGQALPIHLHQISASPRDLNELPEYSDDSRALDKLIDGTNITMEDEHMWLIPFSPGL 1314
Cdd:pfam14652    1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIPIQLSNITASPRDLNDLPGYSGDYRTLDKLIDGTNVTTDDEHMWLIPFSPGK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1315 DHVVTIRLDRAESIAGLRFWNYNKSPEDTYRGAKIVHVSLDGLCVSPPEGFLIRKGPGNCHFDFAQEILF--VDYLRAQL 1392
Cdd:pfam14652   81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPEGFLLRKAPGNCHFDFAQTISFpnVDKVNPPS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1393 LPQPAR-RLDMRSLECASMDYEAPLMPCGFIFQFQLLTSWGDPYYIGLTGLELYDERGEKIPLSENNIAAFPDSVNSLEG 1471
Cdd:pfam14652  161 KQSESQlRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1472 VGGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYAKTPHRGVKEFGLLVDDLLVYNGIL 1551
Cdd:pfam14652  241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNGIL 320


                   ...
gi 767988365  1552 AMV 1554
Cdd:pfam14652  321 RKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 986-1130 1.06e-35

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 138.95  E-value: 1.06e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   986 DFKIPVLPYGQRLVIDIKSTWGDRHYVGLNGIEIFSSKGEPVQI--SNIKADPPDINILPAYGKDPRVVTNLIDGVNRTQ 1063
Cdd:pfam14652  180 DYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLteNNIAAFPDSVNVLDGVSGDVRTPDKLIDGVNNTN 259

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767988365  1064 DDMHVWLAPFTRGRSHSITIDFTHPCHVALIRIWNYNKSrihSFRGVKDITMLLDTQCIFEGEIAKA 1130
Cdd:pfam14652  260 DGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKT---PSRGVKEFAILVDDLLIYNGILRKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 503-628 1.52e-03

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 42.65  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   503 EILSNWGNSWWVGLTEVEFFDLNDTKLYVS-------PHDVDIRNTA-----TPGELGRLVNRNLAGKkdsSPWTCPFHP 570
Cdd:pfam14652  195 QLLSTWGDPYYIGLNGLELYDENGELIPLTenniaafPDSVNVLDGVsgdvrTPDKLIDGVNNTNDGR---HMWLAPILP 271

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   571 PL-QLFFVIRNTrqlgDFHLAKIKVRNYW-TADGdldiGAKNVKLYVNRNLIFNGKLDKG 628
Cdd:pfam14652  272 GLvNRIYVIFDQ----PITVSMIKIWNYSkTPSR----GVKEFAILVDDLLIYNGILRKA 323
 
Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 1235-1554 0e+00

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 611.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1235 LNFTASWGDLHYLGLTGLEVVGKEGQALPIHLHQISASPRDLNELPEYSDDSRALDKLIDGTNITMEDEHMWLIPFSPGL 1314
Cdd:pfam14652    1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIPIQLSNITASPRDLNDLPGYSGDYRTLDKLIDGTNVTTDDEHMWLIPFSPGK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1315 DHVVTIRLDRAESIAGLRFWNYNKSPEDTYRGAKIVHVSLDGLCVSPPEGFLIRKGPGNCHFDFAQEILF--VDYLRAQL 1392
Cdd:pfam14652   81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPEGFLLRKAPGNCHFDFAQTISFpnVDKVNPPS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1393 LPQPAR-RLDMRSLECASMDYEAPLMPCGFIFQFQLLTSWGDPYYIGLTGLELYDERGEKIPLSENNIAAFPDSVNSLEG 1471
Cdd:pfam14652  161 KQSESQlRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365  1472 VGGDVRTPDKLIDQVNDTSDGRHMWLAPILPGLVNRVYVIFDLPTTVSMIKLWNYAKTPHRGVKEFGLLVDDLLVYNGIL 1551
Cdd:pfam14652  241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNGIL 320


                   ...
gi 767988365  1552 AMV 1554
Cdd:pfam14652  321 RKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 986-1130 1.06e-35

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 138.95  E-value: 1.06e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   986 DFKIPVLPYGQRLVIDIKSTWGDRHYVGLNGIEIFSSKGEPVQI--SNIKADPPDINILPAYGKDPRVVTNLIDGVNRTQ 1063
Cdd:pfam14652  180 DYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLteNNIAAFPDSVNVLDGVSGDVRTPDKLIDGVNNTN 259

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767988365  1064 DDMHVWLAPFTRGRSHSITIDFTHPCHVALIRIWNYNKSrihSFRGVKDITMLLDTQCIFEGEIAKA 1130
Cdd:pfam14652  260 DGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKT---PSRGVKEFAILVDDLLIYNGILRKA 323
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 503-628 1.52e-03

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 42.65  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   503 EILSNWGNSWWVGLTEVEFFDLNDTKLYVS-------PHDVDIRNTA-----TPGELGRLVNRNLAGKkdsSPWTCPFHP 570
Cdd:pfam14652  195 QLLSTWGDPYYIGLNGLELYDENGELIPLTenniaafPDSVNVLDGVsgdvrTPDKLIDGVNNTNDGR---HMWLAPILP 271

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988365   571 PL-QLFFVIRNTrqlgDFHLAKIKVRNYW-TADGdldiGAKNVKLYVNRNLIFNGKLDKG 628
Cdd:pfam14652  272 GLvNRIYVIFDQ----PITVSMIKIWNYSkTPSR----GVKEFAILVDDLLIYNGILRKA 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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