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Conserved domains on  [gi|767988495|ref|XP_011544125|]
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aquaporin-8 isoform X2 [Homo sapiens]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 40-118 3.86e-14

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member cd00333:

Pssm-ID: 444743  Cd Length: 228  Bit Score: 66.51  E-value: 3.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495  40 LVELLGSALFIFIGCLSVIE-NGTDTGLLQPalahgLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVAN---HWNFHW 115
Cdd:cd00333  134 FVEFIGTFILVLVVFATTDDpNGPPPGGLAP-----LAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFW 208


                 ...
gi 767988495 116 IYW 118
Cdd:cd00333  209 VYW 211
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 40-118 3.86e-14

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 66.51  E-value: 3.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495  40 LVELLGSALFIFIGCLSVIE-NGTDTGLLQPalahgLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVAN---HWNFHW 115
Cdd:cd00333  134 FVEFIGTFILVLVVFATTDDpNGPPPGGLAP-----LAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFW 208


                 ...
gi 767988495 116 IYW 118
Cdd:cd00333  209 VYW 211
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 35-118 5.11e-14

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 66.19  E-value: 5.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495   35 FVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIAtlgnIRGPVSGGCMNPARAFGPAVVANHWNFH 114
Cdd:pfam00230 130 AGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHL----AGGPYTGASMNPARSFGPAVVLWKWDDH 205


                  ....
gi 767988495  115 WIYW 118
Cdd:pfam00230 206 WVYW 209
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 40-118 4.55e-12

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 60.91  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495  40 LVELLGSALFIFigclsVIENGTDTGLLQPALAhGLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVA------NHWNF 113
Cdd:COG0580  135 LTEIIGTFVLVF-----VILGITDKRAAPGGLA-PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGY 208


                 ....*
gi 767988495 114 HWIYW 118
Cdd:COG0580  209 LWVPI 213
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 35-118 1.91e-10

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 56.54  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495   35 FVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGnirgPVSGGCMNPARAFGPAVVANHWNF- 113
Cdd:TIGR00861 121 SGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIGLLVFLIHLSMG----PYTGTGMNPARSLGPALFAGLAGWg 196


                  ....*.
gi 767988495  114 -HWIYW 118
Cdd:TIGR00861 197 nHWVYW 202
PLN00166 PLN00166
aquaporin TIP2; Provisional
 75-118 5.73e-09

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 53.02  E-value: 5.73e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767988495  75 LALGLVIATLGNIRGPVSGGCMNPARAFGPAVVANHWNFHWIYW 118
Cdd:PLN00166 175 IAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYW 218
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 40-118 3.86e-14

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 66.51  E-value: 3.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495  40 LVELLGSALFIFIGCLSVIE-NGTDTGLLQPalahgLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVAN---HWNFHW 115
Cdd:cd00333  134 FVEFIGTFILVLVVFATTDDpNGPPPGGLAP-----LAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFW 208


                 ...
gi 767988495 116 IYW 118
Cdd:cd00333  209 VYW 211
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 35-118 5.11e-14

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 66.19  E-value: 5.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495   35 FVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIAtlgnIRGPVSGGCMNPARAFGPAVVANHWNFH 114
Cdd:pfam00230 130 AGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHL----AGGPYTGASMNPARSFGPAVVLWKWDDH 205


                  ....
gi 767988495  115 WIYW 118
Cdd:pfam00230 206 WVYW 209
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 40-118 4.55e-12

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 60.91  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495  40 LVELLGSALFIFigclsVIENGTDTGLLQPALAhGLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVA------NHWNF 113
Cdd:COG0580  135 LTEIIGTFVLVF-----VILGITDKRAAPGGLA-PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGY 208


                 ....*
gi 767988495 114 HWIYW 118
Cdd:COG0580  209 LWVPI 213
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 35-118 1.91e-10

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 56.54  E-value: 1.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495   35 FVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGnirgPVSGGCMNPARAFGPAVVANHWNF- 113
Cdd:TIGR00861 121 SGQAFFVEFIGTAILVLVIFATTDDRNRVPRGGFAPLAIGLLVFLIHLSMG----PYTGTGMNPARSLGPALFAGLAGWg 196


                  ....*.
gi 767988495  114 -HWIYW 118
Cdd:TIGR00861 197 nHWVYW 202
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 35-109 2.66e-09

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 53.48  E-value: 2.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495   35 FVQPCLVELLGSALFIFIGCLSVI------ENGTDTGLLQPALAHGLALGLVIATLGNIrgpvSGGCMNPARAFGPAVVA 108
Cdd:pfam00230   7 FLRAVIAEFLATLLFVFFGVGSALgvkklvSSLAVSGLLAVALAFGLALATLVYCAGHI----SGAHLNPAVTLALLVGR 82


                  .
gi 767988495  109 N 109
Cdd:pfam00230  83 R 83
PLN00166 PLN00166
aquaporin TIP2; Provisional
 75-118 5.73e-09

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 53.02  E-value: 5.73e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767988495  75 LALGLVIATLGNIRGPVSGGCMNPARAFGPAVVANHWNFHWIYW 118
Cdd:PLN00166 175 IAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYW 218
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 74-117 6.94e-09

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 52.55  E-value: 6.94e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767988495  74 GLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVAnhWNFH--WIY 117
Cdd:PLN00183 193 GFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVS--WDFKdiWIY 236
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 39-109 5.62e-08

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 49.94  E-value: 5.62e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767988495  39 CLVELLGSALFIFIGCLSVI----ENGTDTGLLQPALAHGLALGLVIATLGNIrgpvSGGCMNPARAFGPAVVAN 109
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLavklAGGASGGLLGIALAWGFAIFVLVYAVGHI----SGGHINPAVTLALAVGGR 73
PLN00027 PLN00027
aquaporin TIP; Provisional
 75-118 4.52e-07

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 47.47  E-value: 4.52e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767988495  75 LALGLVIATLGNIRGPVSGGCMNPARAFGPAVVANHWNFHWIYW 118
Cdd:PLN00027 177 IAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYW 220
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 74-117 1.08e-06

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 46.44  E-value: 1.08e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767988495  74 GLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVANHWNFHWIY 117
Cdd:PLN00182 191 GIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVY 234
PLN00026 PLN00026
aquaporin NIP; Provisional
 74-117 3.70e-06

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 44.85  E-value: 3.70e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767988495  74 GLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVANHWNFHWIY 117
Cdd:PLN00026 219 GIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIY 262
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 37-99 8.68e-06

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 43.58  E-value: 8.68e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767988495  37 QPCLVELLGSALFIFIGCLSV-IENGT--DTGLLQPALAHGLALGLVIATLgnirGPVSGGCMNPA 99
Cdd:COG0580    4 KRLLAEFLGTFILVLLGCGVVaVLAGTkgGIGWLGIALAWGLAVLAGVYAF----GHISGAHLNPA 65
PLN00184 PLN00184
aquaporin NIP1; Provisional
 74-117 1.91e-05

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 43.09  E-value: 1.91e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767988495  74 GLALGLVIATLGNIRGPVSGGCMNPARAFGPAVVANHWNFHWIY 117
Cdd:PLN00184 210 GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIY 253
PLN00167 PLN00167
aquaporin TIP5; Provisional
 75-118 5.74e-05

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 41.43  E-value: 5.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767988495  75 LALGLVIATLGNIRGPVSGGCMNPARAFGPAVVANHWNFHWIYW 118
Cdd:PLN00167 178 LAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYW 221
PLN00184 PLN00184
aquaporin NIP1; Provisional
 35-99 4.57e-04

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 38.85  E-value: 4.57e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767988495  35 FVQPCLVELLGSALFIFIGCLSVIEN-GTDTGLLQPALAhgLALGLVIATLGNIRGPVSGGCMNPA 99
Cdd:PLN00184  53 FLQKLIAEVLGTYFLVFTGCASVVVNmQNDNVVTLPGIA--IVWGLTIMVLIYSLGHISGAHINPA 116
PLN00166 PLN00166
aquaporin TIP2; Provisional
 40-109 7.33e-04

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 38.38  E-value: 7.33e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767988495  40 LVELLGSALFIFIGCLSVIENGTDT--------GLLQPALAHGLALGLVIATLGNIrgpvSGGCMNPARAFGPAVVAN 109
Cdd:PLN00166  22 LSEFIATLLFVFAGVGSAIAFAKLTsdaaldpaGLVAVAVAHAFALFVGVSIAANI----SGGHLNPAVTLGLAIGGN 95
PLN00027 PLN00027
aquaporin TIP; Provisional
 40-109 1.06e-03

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 37.84  E-value: 1.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767988495  40 LVELLGSALFIFIGCLS------VIENGTDT--GLLQPALAHGLALGLVIATLGNIrgpvSGGCMNPARAFGPAVVAN 109
Cdd:PLN00027  24 LAEFISTLIFVFAGEGSgmafnkLTDNGSTTpaGLVAAALAHAFALFVAVSVGANI----SGGHVNPAVTFGAFIGGN 97
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 10-106 1.19e-03

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 37.80  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767988495  10 EPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIG---CLSVIENGTDTGLLqpALAHGLALGLVIATLGN 86
Cdd:PTZ00016  24 DEEVAEAQKRPPGGQNFWAPREYRPNVREYVAEFLGTFVLLFFGegvVATTHTVGNNGDYL--AITIGWGLGVTFGLLVS 101

                         90       100
                 ....*....|....*....|
gi 767988495  87 IRgpVSGGCMNPARAFGPAV 106
Cdd:PTZ00016 102 AG--ISGGHLNPAVTLGNAV 119
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 42-108 5.31e-03

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 35.74  E-value: 5.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767988495   42 ELLGSALFIFIGCLSV--------IENGTDTGLLQPALAHGLALGLVIATLGNIrgpvSGGCMNPARAFGPAVVA 108
Cdd:TIGR00861   2 EFLGTFLLVFFGVGSAlgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGI----SGAHLNPAVTIALLLGR 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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