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Conserved domains on  [gi|768031740|ref|XP_011544479|]
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serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PPP2R3B cd21507
serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric ...
129-483 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR70 (also known as protein phosphatase 2 regulatory subunit B'' subunit beta, PR48, NYREN8, PPP2R3L, or PPP2R3LY) that is encoded by the PPP2R3B gene. This substrate-recognizing subunit of PP2A has a two-domain elongated structure with two calcium EF-hands, each displaying different affinities to Ca2+. PPP2R3B/PR70 is a gonosomal melanoma tumor suppressor gene; PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication.


:

Pssm-ID: 410340  Cd Length: 355  Bit Score: 784.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 129 YFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQ 208
Cdd:cd21507    1 YFPRGCPKDSVNVDAVIAKIENTFSQFPNERATLDDMGKVAKACDCPLYWKGPLFYAAGGERTGSVSVHKFVAMWRKILQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 209 NCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRR 288
Cdd:cd21507   81 NCHDDAAKFVHLLMKPGCNYLVQEDFIPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYTVNRSWSGRITCTELRR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 289 SSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQK 368
Cdd:cd21507  161 SSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLYIDQKDLARHNDHAISNRMIERIFSGAVTRGRKAQK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 369 EGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPR 448
Cdd:cd21507  241 EGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMYELEYFYEEQCQKLDNMAIEPLPFEDCLCQMLDLVKPR 320
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 768031740 449 TEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQK 483
Cdd:cd21507  321 TEGKITLHDLKRCKLANVFFDTFFNIEKYLDHEQK 355
 
Name Accession Description Interval E-value
PPP2R3B cd21507
serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric ...
129-483 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR70 (also known as protein phosphatase 2 regulatory subunit B'' subunit beta, PR48, NYREN8, PPP2R3L, or PPP2R3LY) that is encoded by the PPP2R3B gene. This substrate-recognizing subunit of PP2A has a two-domain elongated structure with two calcium EF-hands, each displaying different affinities to Ca2+. PPP2R3B/PR70 is a gonosomal melanoma tumor suppressor gene; PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication.


Pssm-ID: 410340  Cd Length: 355  Bit Score: 784.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 129 YFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQ 208
Cdd:cd21507    1 YFPRGCPKDSVNVDAVIAKIENTFSQFPNERATLDDMGKVAKACDCPLYWKGPLFYAAGGERTGSVSVHKFVAMWRKILQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 209 NCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRR 288
Cdd:cd21507   81 NCHDDAAKFVHLLMKPGCNYLVQEDFIPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYTVNRSWSGRITCTELRR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 289 SSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQK 368
Cdd:cd21507  161 SSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLYIDQKDLARHNDHAISNRMIERIFSGAVTRGRKAQK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 369 EGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPR 448
Cdd:cd21507  241 EGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMYELEYFYEEQCQKLDNMAIEPLPFEDCLCQMLDLVKPR 320
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 768031740 449 TEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQK 483
Cdd:cd21507  321 TEGKITLHDLKRCKLANVFFDTFFNIEKYLDHEQK 355
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
212-301 4.55e-51

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 169.85  E-value: 4.55e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740  212 DDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSF 291
Cdd:pfam17958   1 DEAARFFRLLKGPGKNYLSREDFYPFVQDVVDTHPGLEFLREAEEFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDL 80
                          90
                  ....*....|
gi 768031740  292 LQNVALLEEE 301
Cdd:pfam17958  81 LKAVRQLDEE 90
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
323-419 1.45e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 42.09  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 323 FWELDTDHDLLIDADDLArhndhALSTKMIDRIFSGAVTRGrkvqkEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDL 402
Cdd:COG5126   11 FDLLDADGDGVLERDDFE-----ALFRRLWATLFSEADTDG-----DGRISREEFVAGMESLFEATVEPFARAAFDLLDT 80
                         90
                 ....*....|....*..
gi 768031740 403 DGDGALSMFELEYFYEE 419
Cdd:COG5126   81 DGDGKISADEFRRLLTA 97
 
Name Accession Description Interval E-value
PPP2R3B cd21507
serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric ...
129-483 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" subunit beta; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR70 (also known as protein phosphatase 2 regulatory subunit B'' subunit beta, PR48, NYREN8, PPP2R3L, or PPP2R3LY) that is encoded by the PPP2R3B gene. This substrate-recognizing subunit of PP2A has a two-domain elongated structure with two calcium EF-hands, each displaying different affinities to Ca2+. PPP2R3B/PR70 is a gonosomal melanoma tumor suppressor gene; PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing the cell division cycle 6 (CDC6)-chromatin licensing and DNA replication factor 1 (CDT1) interaction, which delays the firing of origins of DNA replication.


Pssm-ID: 410340  Cd Length: 355  Bit Score: 784.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 129 YFPRGRPQDSVNVDAVISKIESTFARFPHERATMDDMGLVAKACGCPLYWKGPLFYGAGGERTGSVSVHKFVAMWRKILQ 208
Cdd:cd21507    1 YFPRGCPKDSVNVDAVIAKIENTFSQFPNERATLDDMGKVAKACDCPLYWKGPLFYAAGGERTGSVSVHKFVAMWRKILQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 209 NCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRR 288
Cdd:cd21507   81 NCHDDAAKFVHLLMKPGCNYLVQEDFIPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYTVNRSWSGRITCTELRR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 289 SSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQK 368
Cdd:cd21507  161 SSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLYIDQKDLARHNDHAISNRMIERIFSGAVTRGRKAQK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 369 EGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPR 448
Cdd:cd21507  241 EGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMYELEYFYEEQCQKLDNMAIEPLPFEDCLCQMLDLVKPR 320
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 768031740 449 TEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQK 483
Cdd:cd21507  321 TEGKITLHDLKRCKLANVFFDTFFNIEKYLDHEQK 355
PPP2R3A cd21506
serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric ...
203-484 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR130 (also known as protein phosphatase 2A regulatory subunit B'' subunit alpha, PR72, or PPP2R3) that is encoded by the PPP2R3A gene. PR130 and PR72 subunits are derived from the same gene through differential splicing; they harbor specific N-terminal domains of different lengths that are encoded by alternatively spliced exons and have identical C-termini. The common C-terminus contains a two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity. The PR130 subunit has been shown to interact with the LIM domain of lipoma-preferred partner (LPP) through a conserved Zn2+-finger-like motif in the N-terminus of PR130.


Pssm-ID: 410339  Cd Length: 284  Bit Score: 552.62  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 203 WRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRIT 282
Cdd:cd21506    1 WRKLLNNCHDDASKFVYLLAKPNCSYLEQEDFIPLLQDIVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 283 CAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTR 362
Cdd:cd21506   81 LTELRKSNFLQTLALLEEEDDINQITDYFSYEHFYVIYCKFWELDTDHDLYIDQKDLARYNDQASSSRIIERIFSGAVTR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 363 GRKVQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQML 442
Cdd:cd21506  161 GNSVQKEGRMSYADFVWFLISEEDKRNPTSIEYWFRCMDLDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQML 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 768031740 443 DLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKYLDHEQKE 484
Cdd:cd21506  241 DLVKPEVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRD 282
PPP2R3A_B-like cd21504
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and ...
203-477 0e+00

serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410337  Cd Length: 274  Bit Score: 547.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 203 WRKILQNCHDDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRIT 282
Cdd:cd21504    1 WKKILAGCHDDASRFFRILKKPDRNYLVPEDFKPFLQDLLDTHPGLEFLQDTPEFQERYAETVIYRIFYSVNRSWSGRIT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 283 CAELRRSSFLQNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTR 362
Cdd:cd21504   81 LRELRRSNLLQALLLLDEEEDINKVLRYFSYEHFYVIYCKFWELDTDHDLLIDKDDLLRYGDHALSPRIVDRIFSGAVRR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 363 GRKvQKEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQML 442
Cdd:cd21504  161 FKS-GKEGKMSYEDFVWFILSEEDKTSPTSIEYWFRCMDLDGDGVLSMYEMEYFYEEQLQRMECLGIEPVPFEDILCQML 239
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768031740 443 DLVKPRTEGKITLQDLKRCKLANVFFDTFFNIEKY 477
Cdd:cd21504  240 DMIKPENEGKITLRDLKRCKLAGNFFNTLFNLNKF 274
PPP2R3 cd21339
serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine ...
213-471 6.93e-171

serine/threonine protein phosphatase 2A regulatory subunit B"; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This family includes PP2A regulatory B'' subunits alpha, beta and gamma, encoded by PPP2R3A, PPP2R3B and PPP2R3C, respectively. It also includes subunit delta encoded by PPP2R3D in mouse. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. Subunits alpha and beta contain two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.


Pssm-ID: 410336  Cd Length: 259  Bit Score: 484.39  E-value: 6.93e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 213 DAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSFL 292
Cdd:cd21339    1 DATKFGLLLYDPGCGYLRQEDFEPYLQDVVPTHPGLDFLKKAPEFHSRYITTVIQRIFYFVNRSWSGKITIQEIRASSFL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 293 QNVALLEEEADINQLTEFFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRGRKVQKEGKI 372
Cdd:cd21339   81 QDLALLEEEEDINQETNWFSYEHFYVIYCKFWELDTDHDLMISKEDLSRYNDAAMSNVFIDRIFSGAVTRGKTIQKEGEM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 373 SYADFVWFLISEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTEGK 452
Cdd:cd21339  161 SYADFVWFLISEEDKKEPTSIEYWFRCLDIDGDGYLSVFELEYFYEEQCERMKIHGIEPLPFQDVLCQILDLVKPKDPGK 240
                        250
                 ....*....|....*....
gi 768031740 453 ITLQDLKRCKLANVFFDTF 471
Cdd:cd21339  241 ITLQDLKRCNIALNFFDTF 259
EF-hand_13 pfam17958
EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B ...
212-301 4.55e-51

EF-hand domain; This entry represents an EF-hand domain found in one of the regulatory B subunits of PP2A.


Pssm-ID: 465586 [Multi-domain]  Cd Length: 90  Bit Score: 169.85  E-value: 4.55e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740  212 DDAAKFVHLLMSPGCNYLVQEDFVPFLQDVVNTHPGLSFLKEASEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSF 291
Cdd:pfam17958   1 DEAARFFRLLKGPGKNYLSREDFYPFVQDVVDTHPGLEFLREAEEFQDKYIQTVIARIFYVVNRSWSGKITLLELRKSDL 80
                          90
                  ....*....|
gi 768031740  292 LQNVALLEEE 301
Cdd:pfam17958  81 LKAVRQLDEE 90
PPP2R3C cd21505
serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric ...
225-484 9.51e-33

serine/threonine protein phosphatase 2A regulatory subunit B" subunit gamma; Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This subfamily includes protein phosphatase subunit G5PR (also known as serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma, G4-1, G5pr, GDRM, SPGF36, or C14orf10) that is encoded by the PPP2R3C gene. It is involved in the control of the dynamic organization of the cortical cytoskeleton and plays an important role in the organization of interphase microtubule arrays in part through the regulation of nucleation geometry. G5PR is involved in the ontogeny of multiple organs, especially critical for testis development and spermatogenesis. PPP2R3C gene variants cause syndromic 46,XY gonadal dysgenesis and impaired spermatogenesis in humans, and thus is emerging as a potential therapeutic target for male infertility.


Pssm-ID: 410338 [Multi-domain]  Cd Length: 382  Bit Score: 129.23  E-value: 9.51e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 225 GCNYLVQEDFVPFLQDVVNTHPGLSFLKEasEFHSRYITTVIQRIFYAVNRSWSGRITCAELRRSSFLQN-VALLEEEAD 303
Cdd:cd21505  129 GDGFLTESDLENYILELIPTLPQLSGLEE--SFYSFYVCTAVRKFFFFLDPLRRGKIRIKDILASPFLDElLELRDEELS 206
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 304 INQLTE-FFSYEHFYVIYCKFWELDTDHDLLIDADDLARHNDHALSTKMIDRIFSGAVTRgrkvqkEGKISYADFVWFLI 382
Cdd:cd21505  207 EELQESnWFSAPSALRVYGQYLNLDKDHNGMLSKQELSRYGKGTLTSVFIDRVFQECLTY------NGEMDYKTFLDFVL 280
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 383 SEEDKKTPTSIEYWFRCMDLDGDGALSMFELEYFYEEQCRRLDSMAIEALPFQDCLCQMLDLVKPRTEGKITLQDLKRCK 462
Cdd:cd21505  281 AMENRKEPQALQYFFRILDLKGQGYLTPFTLNYFFRAIQEKMKEHGQEPVSFEDVKDEIFDMVKPKDPLKITLQDLINSG 360
                        250       260
                 ....*....|....*....|....*.
gi 768031740 463 LAnvffDTFFNI----EKYLDHEQKE 484
Cdd:cd21505  361 QG----DTVVSIlidlNGFWAYENRE 382
EF-hand_7 pfam13499
EF-hand domain pair;
316-417 1.20e-08

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 51.49  E-value: 1.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740  316 FYVIYCKFWELDTDHDllidaddlarhndhalstkmidrifsgavtrgrkvqkeGKISYADFVWFL--ISEEDKKTPTSI 393
Cdd:pfam13499   1 EEKLKEAFKLLDSDGD--------------------------------------GYLDVEELKKLLrkLEEGEPLSDEEV 42
                          90       100
                  ....*....|....*....|....
gi 768031740  394 EYWFRCMDLDGDGALSMFELEYFY 417
Cdd:pfam13499  43 EELFKEFDLDKDGRISFEEFLELY 66
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
323-419 1.45e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 42.09  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 323 FWELDTDHDLLIDADDLArhndhALSTKMIDRIFSGAVTRGrkvqkEGKISYADFVWFLISEEDKKTPTSIEYWFRCMDL 402
Cdd:COG5126   11 FDLLDADGDGVLERDDFE-----ALFRRLWATLFSEADTDG-----DGRISREEFVAGMESLFEATVEPFARAAFDLLDT 80
                         90
                 ....*....|....*..
gi 768031740 403 DGDGALSMFELEYFYEE 419
Cdd:COG5126   81 DGDGKISADEFRRLLTA 97
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
323-413 9.21e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 36.69  E-value: 9.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768031740 323 FWELDTDHDLLIDADDLARHNDH---ALSTKMIDRIFSGAVTRGRkvqkeGKISYADFVWFLisEEDKKTPTSIEYWFRC 399
Cdd:COG5126   39 FSEADTDGDGRISREEFVAGMESlfeATVEPFARAAFDLLDTDGD-----GKISADEFRRLL--TALGVSEEEADELFAR 111
                         90
                 ....*....|....
gi 768031740 400 MDLDGDGALSMFEL 413
Cdd:COG5126  112 LDTDGDGKISFEEF 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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