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Conserved domains on  [gi|805752161|ref|XP_012140681|]
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PREDICTED: pyruvate kinase-like isoform X3 [Megachile rotundata]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 185-672 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 732.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 185 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglnVPVAIALDTKGPEIRTG 264
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 265 LLEGGgsAEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV-ITTTIENGG 343
Cdd:cd00288   76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 344 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 423
Cdd:cd00288  153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 424 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 503
Cdd:cd00288  233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 504 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 583
Cdd:cd00288  313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 584 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPlADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGF 663
Cdd:cd00288  393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                 ....*....
gi 805752161 664 TNTLRVVTV 672
Cdd:cd00288  472 TNTMRILTV 480
Mito_carr pfam00153
Mitochondrial carrier protein;
4-91 3.80e-14

Mitochondrial carrier protein;


:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 68.45  E-value: 3.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161    4 SGFSGAVGGVLGTPGDVINVRMQNDIKLAPELRRNykhALDGIVCIVQQEGFSKLFSGCTTATLRAALMTIGQLSFYDQI 83
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETL 88


                  ....*...
gi 805752161   84 KITMIESG 91
Cdd:pfam00153  89 KRLLLKKL 96
Mito_carr super family cl37969
Mitochondrial carrier protein;
93-153 3.12e-08

Mitochondrial carrier protein;


The actual alignment was detected with superfamily member pfam00153:

Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 51.50  E-value: 3.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752161   93 FEDNPVTHVLSSVCAGAVATTLTQPLDVLKTRAMNA---KPGEFKSLMDLFLYTAKL-GPLAFFK 153
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQggsGKSKGRGILDCFKKIYKEeGIRGLYK 65
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 185-672 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 732.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 185 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglnVPVAIALDTKGPEIRTG 264
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 265 LLEGGgsAEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV-ITTTIENGG 343
Cdd:cd00288   76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 344 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 423
Cdd:cd00288  153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 424 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 503
Cdd:cd00288  233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 504 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 583
Cdd:cd00288  313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 584 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPlADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGF 663
Cdd:cd00288  393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                 ....*....
gi 805752161 664 TNTLRVVTV 672
Cdd:cd00288  472 TNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 185-669 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 656.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  185 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTG 264
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKL------GRPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  265 LLEGGgsaEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGM 344
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  345 LGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLD 423
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  424 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 503
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  504 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 583
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  584 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEdaplaDWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG-WRQGSG 662
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVD-----EEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 805752161  663 FTNTLRV 669
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 189-672 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 647.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 268
Cdd:COG0469    7 IVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREA----AKE--LGRPVAILLDLQGPKIRTGKFKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GGsaeVELQKGQTFKLSTDKahaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 348
Cdd:COG0469   81 GP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 349 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIEA 428
Cdd:COG0469  155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 429 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 508
Cdd:COG0469  235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 509 KGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKclASAIIVITTTGRSAHLIAKYRP 588
Cdd:COG0469  315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLG--AKAIVAFTESGSTARRISRYRP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 589 RCPIIAVTRFHQVARQAHLHRGILPLYYEDapladwVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTNTL 667
Cdd:COG0469  393 KVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTL 466


                 ....*
gi 805752161 668 RVVTV 672
Cdd:COG0469  467 KVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 185-537 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 558.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  185 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSARnglnvpVAIALDTKGPEIRTG 264
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRTG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  265 LLEGGgSAEVELQKGQTFKLSTDKAHAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE-VITTTIENGG 343
Cdd:pfam00224  76 NTKDG-KKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  344 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 423
Cdd:pfam00224 155 VIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  424 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 503
Cdd:pfam00224 235 EILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 805752161  504 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIF 537
Cdd:pfam00224 315 SGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 189-656 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 547.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 268
Cdd:PRK05826   8 IVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI----AAK--LGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GgsaEVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 348
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQK--EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 349 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLDEIIE 427
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 428 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 507
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 508 AKGEYPLECVRTMANICKEAEaAIWQIQIFHDLANKALpPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 587
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQF-DRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFR 394

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805752161 588 PRCPIIAVTRFHQVARQAHLHRGILPLYYEDApladwvKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG 656
Cdd:PRK05826 395 PGAPIFAVTRDEKTQRRLALYRGVYPVLFDSA------ADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
Mito_carr pfam00153
Mitochondrial carrier protein;
4-91 3.80e-14

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 68.45  E-value: 3.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161    4 SGFSGAVGGVLGTPGDVINVRMQNDIKLAPELRRNykhALDGIVCIVQQEGFSKLFSGCTTATLRAALMTIGQLSFYDQI 83
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETL 88


                  ....*...
gi 805752161   84 KITMIESG 91
Cdd:pfam00153  89 KRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
93-153 3.12e-08

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 51.50  E-value: 3.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752161   93 FEDNPVTHVLSSVCAGAVATTLTQPLDVLKTRAMNA---KPGEFKSLMDLFLYTAKL-GPLAFFK 153
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQggsGKSKGRGILDCFKKIYKEeGIRGLYK 65
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 185-672 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 732.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 185 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglnVPVAIALDTKGPEIRTG 264
Cdd:cd00288    2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRTG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 265 LLEGGgsAEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV-ITTTIENGG 343
Cdd:cd00288   76 LFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 344 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 423
Cdd:cd00288  153 VLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 424 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 503
Cdd:cd00288  233 EILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 504 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 583
Cdd:cd00288  313 SGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLV 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 584 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPlADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGF 663
Cdd:cd00288  393 SKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGS 471


                 ....*....
gi 805752161 664 TNTLRVVTV 672
Cdd:cd00288  472 TNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 185-669 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 656.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  185 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTG 264
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKL------GRPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  265 LLEGGgsaEVELQKGQTFKLSTDKAhAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGM 344
Cdd:TIGR01064  75 EIKGG---EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  345 LGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLD 423
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  424 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 503
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  504 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLI 583
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  584 AKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEdaplaDWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG-WRQGSG 662
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVD-----EEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 805752161  663 FTNTLRV 669
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 189-672 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 647.48  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 268
Cdd:COG0469    7 IVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREA----AKE--LGRPVAILLDLQGPKIRTGKFKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GGsaeVELQKGQTFKLSTDKahaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 348
Cdd:COG0469   81 GP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 349 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIEA 428
Cdd:COG0469  155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 429 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 508
Cdd:COG0469  235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 509 KGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKclASAIIVITTTGRSAHLIAKYRP 588
Cdd:COG0469  315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLG--AKAIVAFTESGSTARRISRYRP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 589 RCPIIAVTRFHQVARQAHLHRGILPLYYEDapladwVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTNTL 667
Cdd:COG0469  393 KVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTL 466


                 ....*
gi 805752161 668 RVVTV 672
Cdd:COG0469  467 KVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 185-537 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 558.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  185 RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSARnglnvpVAIALDTKGPEIRTG 264
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRTG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  265 LLEGGgSAEVELQKGQTFKLSTDKAHAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE-VITTTIENGG 343
Cdd:pfam00224  76 NTKDG-KKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNGG 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  344 MLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLD 423
Cdd:pfam00224 155 VIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  424 EIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVML 503
Cdd:pfam00224 235 EILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVML 314

                         330       340       350
                  ....*....|....*....|....*....|....
gi 805752161  504 SGETAKGEYPLECVRTMANICKEAEAAIWQIQIF 537
Cdd:pfam00224 315 SGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 189-656 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 547.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARngLNVPVAIALDTKGPEIRTGLLEG 268
Cdd:PRK05826   8 IVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREI----AAK--LGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GgsaEVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 348
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQK--EEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 349 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-KNIKIISKIENQQGMTNLDEIIE 427
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 428 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 507
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 508 AKGEYPLECVRTMANICKEAEaAIWQIQIFHDLANKALpPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 587
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQF-DRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFR 394

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 805752161 588 PRCPIIAVTRFHQVARQAHLHRGILPLYYEDApladwvKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTG 656
Cdd:PRK05826 395 PGAPIFAVTRDEKTQRRLALYRGVYPVLFDSA------ADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 189-654 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 541.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTGLLEG 268
Cdd:PLN02461  25 IVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANT------GILCAVMLDTKGPEIRTGFLKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GGSaeVELQKGQTFKLSTDKAHaeKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE--VITTTIENGGMLG 346
Cdd:PLN02461  99 GKP--VQLKQGQEITITTDYSI--KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEagTVRCRCENSAMLG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 347 SRKGVNLPGVPVDLPAVSEKDKSD-LQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEI 425
Cdd:PLN02461 175 ERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDI 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 426 IEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSG 505
Cdd:PLN02461 255 LAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSG 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 506 ETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAK 585
Cdd:PLN02461 335 ETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAK 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 586 YRPRCPIIAV------TRFHQ-------VARQAHLHRGILPLYYEDAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVV 652
Cdd:PLN02461 415 YRPAVPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVV 494


                 ..
gi 805752161 653 VV 654
Cdd:PLN02461 495 AL 496
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 211-672 3.44e-178

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 514.60  E-value: 3.44e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 211 MNIARLNFSHGSHEYHAETISNVRQAQKNLsarnGLNVpvAIALDTKGPEIRTGLLEGGGSAeveLQKGQTFKLSTDKAH 290
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAEL----GVNI--AIALDTKGPEIRTGLFVGGEAV---MERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 291 AEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE-VITTTIENGGMLGSRKGVNLPGVPVDLPAVSEKDKS 369
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 370 DLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVF 449
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 450 LAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEA 529
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 530 AIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHR 609
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 805752161 610 GILPLYYeDAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGFTNTLRVVTV 672
Cdd:PTZ00300 392 GVESVFF-DAERLGHDEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PRK09206 PRK09206
pyruvate kinase PykF;
189-669 6.50e-178

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 514.60  E-value: 6.50e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTGLLEG 268
Cdd:PRK09206   6 IVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKT------GKKAAILLDTKGPEIRTMKLEG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GgsAEVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 348
Cdd:PRK09206  80 G--NDVSLKAGQTFTFTTDKS--VVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGEN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 349 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGE-KGKNIKIISKIENQQGMTNLDEIIE 427
Cdd:PRK09206 156 KGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhGGENIQIISKIENQEGLNNFDEILE 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 428 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 507
Cdd:PRK09206 236 ASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGES 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 508 AKGEYPLECVRTMANICKEAEAAIwQIQIFHDLANKALppvDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 587
Cdd:PRK09206 316 AKGKYPLEAVSIMATICERTDRVM-NSRLESNNDNRKL---RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYF 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 588 PRCPIIAVTRFHQVARQAHLHRGILPLyyedapLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQGSGFTNTL 667
Cdd:PRK09206 392 PDATILALTTNEKTARQLVLSKGVVPQ------LVKEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGTTNTA 465


                 ..
gi 805752161 668 RV 669
Cdd:PRK09206 466 SV 467
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 189-672 8.89e-172

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 500.44  E-value: 8.89e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSarnglNVPVAIALDTKGPEIRTGLLEG 268
Cdd:PTZ00066  42 IVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARP-----NANLGILLDTKGPEIRTGFLKN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GgsAEVELQKGQTFKLSTDkaHAEKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 348
Cdd:PTZ00066 117 H--KPITLKEGQTLKITTD--YTFLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGER 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 349 KGVNLPGVPVDLPAVSEKDKSD-LQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNIKIISKIENQQGMTNLDEIIE 427
Cdd:PTZ00066 193 KNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILA 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 428 ASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGET 507
Cdd:PTZ00066 273 ESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGET 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 508 AKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKYR 587
Cdd:PTZ00066 353 ANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYR 432

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 588 PRCPIIAVTRFHQVARQAHLHRGILplyyedAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTNT 666
Cdd:PTZ00066 433 PSCTILALSASPSVVKSLSVARGVT------TYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEvAGSSNL 506


                 ....*.
gi 805752161 667 LRVVTV 672
Cdd:PTZ00066 507 MKVVKI 512
PRK06354 PRK06354
pyruvate kinase; Provisional
 179-672 1.16e-166

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 490.21  E-value: 1.16e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 179 SRASFVRLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKG 258
Cdd:PRK06354   2 SLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKL------GKTVGILQDLQG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 259 PEIRTGLLEGGGsaeVELQKGQTFKLSTDKAhaeKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEV--IT 336
Cdd:PRK06354  76 PKIRLGRFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLH 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 337 TTIENGGMLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEK-GKNIKIISKIEN 415
Cdd:PRK06354 150 CKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 416 QQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAIL 495
Cdd:PRK06354 230 QEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAIL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 496 DGADCVMLSGETAKGEYPLECVRTMANICKEAEAAIWQIQIF-HDLANKALPPVDATHAVAVAAVEASvkclASAIIVIT 574
Cdd:PRK06354 310 DGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILsKRPEFTTTITNAISQAVSHIALQLD----AAAIVTLT 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 575 TTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDAPLADWVkdvdvrVQTGLNFGKSRGFVKTGDSVVVV 654
Cdd:PRK06354 386 KSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDET------FDAAINVAQESGLLKQGDLVVIT 459

                        490
                 ....*....|....*....
gi 805752161 655 TGWRQG-SGFTNTLRVVTV 672
Cdd:PRK06354 460 AGTLVGeSGSTDLMKVHVV 478
PRK06247 PRK06247
pyruvate kinase; Provisional
 189-672 5.36e-143

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 425.49  E-value: 5.36e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 189 IICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDTKGPEIRTGLLEG 268
Cdd:PRK06247   9 ILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDET------GRPIGILADLQGPKLRLGRFAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 269 GgsaEVELQKGQTFKLSTDKAHaekGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSR 348
Cdd:PRK06247  83 G---KVQLANGQTFRLDVDDAP---GDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 349 KGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKgknIKIISKIENQQGMTNLDEIIEA 428
Cdd:PRK06247 157 KGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAIDRLEAIVEA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 429 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 508
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 509 KGEYPLECVRTMANICKEAEAAiwqiQIFHDL--ANKALPPVDATHAVAVAAVEASVKCLASAIIVITTTGRSAHLIAKY 586
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERD----PTYPPLihAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARE 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 587 RPRCPIIAVTRFHQVARQAHLHRGIlplyyeDAPLADWVKDVDVRVQTGLNFGKSRGFVKTGDSVVVVTGWRQG-SGFTN 665
Cdd:PRK06247 390 RPPLPILALTPNPETARRLALTWGV------HCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPGSTN 463


                 ....*..
gi 805752161 666 TLRVVTV 672
Cdd:PRK06247 464 MLRIAYI 470
PLN02765 PLN02765
pyruvate kinase
 178-673 8.15e-118

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 362.45  E-value: 8.15e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 178 ESRASFV-RLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLsarnglNVPVAIALDT 256
Cdd:PLN02765  20 PSKPSFFpALTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNT------KKLCAVMLDT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 257 KGPEIrtGLLEGGGSAeVELQKGQTFKLSTDKAhaEKGNANLVYVDYDNISKVLKVGNRVFVDDGLIS--------LIVT 328
Cdd:PLN02765  94 VGPEL--QVINKTEKP-ISLKAGNTVTLTPDQS--KEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 329 AVSPEVITTTIENGGML-GSRKGVNLPGVPVDLPAVSEKDKSDL-QFGVEQEVDMIFASFIRNAAALTEIRSILGEKG-K 405
Cdd:PLN02765 169 EVKGDDVVCTVKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlS 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 406 NIKIISKIENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVIcATQMLESMVKKPRATRA 485
Cdd:PLN02765 249 QTQIFAKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRA 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 486 ETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEAAIWQIQIFHDLANKALPPVDATHAVAVAAVEASVKC 565
Cdd:PLN02765 328 EATDVANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKV 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 566 LASAIIVITTTGRSAHLIAKYRPRCPIIAVT-----------RFH--QVARQAHLHRGILPLyyedapLADWVKDVDVRV 632
Cdd:PLN02765 408 KASVIIVFTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwSFTgaFQARQCLIVRGLFPM------LADPRHSAESTS 481

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*...
gi 805752161 633 QTG-------LNFGKSRGFVKTGDSVVVVtgwrQGSGFTNTLRVVTVD 673
Cdd:PLN02765 482 ATNesvlkvaLDHGKAAGVIKSHDRVVVC----QKVGDSSVVKIIELD 525
PLN02623 PLN02623
pyruvate kinase
 158-661 1.80e-109

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 342.68  E-value: 1.80e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 158 PNTQALYAQSQLDHMCALDIESRASFVRLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVrqaq 237
Cdd:PLN02623  83 EDNEEVLLEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLV---- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 238 KNLSARNGLNVpVAIALDTKGPEIRTGLLegggSAEVELQKGQTFKLSTDKAhaeKGNANLVYVDYDNISKVLKVGNRVF 317
Cdd:PLN02623 159 KEYNAQSKDNV-IAIMLDTKGPEVRSGDL----PQPIMLEEGQEFTFTIKRG---VSTEDCVSVNYDDFVNDVEVGDMLL 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 318 VDDGLISLIVTAVSPEVITTTIENGGMLGSRKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIR 397
Cdd:PLN02623 231 VDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELK 310

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 398 SILGEKGKNIKIISKIENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMV 477
Cdd:PLN02623 311 DYLKSCNADIHVIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMI 390

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 478 KKPRATRAETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEAAiwqiqifhdLANKALPPVDATHAVAVA 557
Cdd:PLN02623 391 VHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEAT---------LPEGTTPPNLGQAFKNHM 461

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 558 A------VEASVKCLASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEdapladWVKDVDVR 631
Cdd:PLN02623 462 SemfafhATMMANTLGTSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQ------FSDDAEET 535

                        490       500       510
                 ....*....|....*....|....*....|....*
gi 805752161 632 VQTGLNFGKSRGFVKTGDSVVVVTG-----WRQGS 661
Cdd:PLN02623 536 FARALSLLLNKGMVKEGEEVALVQSgrqpiWRSES 570
PRK06739 PRK06739
pyruvate kinase; Validated
 190-528 2.06e-103

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 319.20  E-value: 2.06e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 190 ICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQaqknlsarngLNVPVAIALDTKGPEIRTGLLEGg 269
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----------LDDSIKILGDVQGPKIRLGEIKG- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 270 gsAEVELQKGQTFKLSTDKAhaeKGNANLVYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPEVITTTIENGGMLGSRK 349
Cdd:PRK06739  75 --EQITLQAGDSFILHTQPV---TGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 350 GVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKNI-KIISKIENQQGMTNLDEIIEA 428
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 429 SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETA 508
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 805752161 509 KGEYPLECVRTMANICKEAE 528
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 184-655 6.07e-91

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 292.03  E-value: 6.07e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 184 VRLSGIICTIGPASRSVETLEKMIETGMNIARLNFSHGSHEYHAETISNVRQaqknLSARNGLNVpvAIALDTKGPEIRT 263
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRR----LNEEKGFAV--AVMMDTEGSEIHM 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 264 GLLEGGGSAEVELQKGQTFKL-STDKAHAEKgnanLVYVDYDNISKVLKVGNRVFVDDGLISL-IVTAVSPEVITTTIEN 341
Cdd:PLN02762  98 GDLGGASSAKAEDGEEWTFTVrKFDGSRPEF----TIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPDVKCKCTDP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 342 GGMLGS------RKGVNLPGVPVDLPAVSEKDKSDLQFGVEQEVDMIFASFIRNAAALTEIRSILGEKGKN--IKIISKI 413
Cdd:PLN02762 174 GLLLPRanltfwRDGSLVRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGVIAKI 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 414 ENQQGMTNLDEIIEASDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANA 493
Cdd:PLN02762 254 ESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEA 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 494 ILDGADCVMLSGETAKGEYP---LECVRT----MANICKEA--EAAIWQIQIFHDLANKalppvdATHAVAVAAVEASVK 564
Cdd:PLN02762 334 VRQRADALMLSGESAMGLYPekaLSVLRSvslrMELWSREEkrHEALELPQLSSSLSDR------ISEEICNSAAKMANN 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 565 CLASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLyyedapLADWVKDVDVRVQTGLNFGKSRGF 644
Cdd:PLN02762 408 LGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPF------RLDFSDDMESNLNKTFSLLKARGM 481

                        490
                 ....*....|.
gi 805752161 645 VKTGDSVVVVT 655
Cdd:PLN02762 482 IKSGDLVIAVS 492
PRK08187 PRK08187
pyruvate kinase; Validated
 206-523 2.76e-50

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 182.52  E-value: 2.76e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 206 MIETGMNIARLNFSHGSHEYHAETISNVRQAQKNLSARnglnvpVAIALDTKGPEIRTGLLeGGGSAEVELQKGQTFKLS 285
Cdd:PRK08187 155 LAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRR------CKILMDLAGPKIRTGAV-AGPLGKTRLYTGDRLALV 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 286 TDKAHAEKGNANL-VYVDYDNISKVLKVGNRVFVDDGLISLIVTAVSPE----VITTTIENGGMLGSRKGVNLPGVPVDL 360
Cdd:PRK08187 228 AQGPPRRIDEEHFqVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGgallEVTHARPKGLKLKPEKGLNFPDTALDL 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 361 PAVSEKDKSDLQFgVEQEVDMIFASFIRNAAALTEIRSILGEKGKN----IKIISKIENQQGMTNLDEIIEASDG----- 431
Cdd:PRK08187 308 PALTEKDRADLDF-VARHADLVGYSFVQSPGDVEALQAALAARRPDdwrkLGLVLKIETPRAVANLPELIVQAAGrqpfg 386

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 432 IMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMVKKPRATRAETSDVANAilDGADCVMLSgetaKGE 511
Cdd:PRK08187 387 VMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDAAMA--ARAECVMLN----KGP 460

                        330
                 ....*....|..
gi 805752161 512 YPLECVRTMANI 523
Cdd:PRK08187 461 YLVEAVTFLDDL 472
PRK14725 PRK14725
pyruvate kinase; Provisional
 203-523 2.99e-40

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 156.26  E-value: 2.99e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 203 LEKMIETGMNIARLNFSHGSHEYHAETISNVRQAqknlSARNGLnvPVAIALDTKGPEIRTGLLEGGG------------ 270
Cdd:PRK14725 158 VRRLLAAGMDIARINCAHDDPEAWRAMIANVRTA----EEELGR--RCRIAMDLAGPKLRTGPIAPGPrviklrptrdal 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 271 ---------------SAEVE-----------------LQKGQTFKLsTDKAHAEK--------GNANLVYVD---Y---- 303
Cdd:PRK14725 232 grvltparlwltaseSPPPSpppgpvglpvdpewlarLEPGDELRF-TDARGKKRkltvtevdDEGVLAEGSqtaYlang 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 304 ----------------------------------------------DNISKV----------LKVGNRVFVDDGLISLIV 327
Cdd:PRK14725 311 tllrlgrhdstrvgglppveqklrlkvgdrlvltrddapgdpaqgdAPPARIsctlpeafraARVGERVWFDDGKIGAVV 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 328 TAVSPEVITTTIENGGMLGSR----KGVNLPGVPVDLPAVSEKDKSDLQFgVEQEVDMIFASFIRNAAALTEIRSILGE- 402
Cdd:PRK14725 391 VKVEADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAF-VAKHADIVALSFVRSPEDVRLLLDALEKl 469

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 403 KGKNIKIISKIENQQGMTNLDEII-EA----SDGIMVARGDLGIEIPPEKVFLAQKCMISRCNKVGKPVICATQMLESMV 477
Cdd:PRK14725 470 GADDLGVVLKIETRRAFENLPRILlEAmrhpRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLA 549

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 805752161 478 KKPRATRAETSDVANAILdgADCVMLSgetaKGEYPLECVRTMANI 523
Cdd:PRK14725 550 KKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDI 589
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
458-673 7.35e-39

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 146.20  E-value: 7.35e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 458 RCNKVGKPVICATQMLESMVKKPRATRAETSDVANAILDGADCVMLSGETAKGEYPLECVRTMANICKEAEAAIwqiqif 537
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDL------ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161 538 hdLANKALPPVDATHAVAVAAVEASVKC------LASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGI 611
Cdd:COG3848   75 --EYREQRVPRAKESSTTITDAISHAVAttaadlGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGV 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 805752161 612 LPLYYEDAPLADWVKDVDVRVQTGlnfgksRGFVKTGDSVVVVTGWRQG-SGFTNTLRVVTVD 673
Cdd:COG3848  153 YPLLVEESASTDEMFAVAVALALE------AGLVKDGDLVVITAGVPVGvSGTTNLLKVHVVG 209
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 567-670 3.70e-34

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 126.06  E-value: 3.70e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161  567 ASAIIVITTTGRSAHLIAKYRPRCPIIAVTRFHQVARQAHLHRGILPLYYEDApladwvKDVDVRVQTGLNFGKSRGFVK 646
Cdd:pfam02887  16 AKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEA------ETTDEMLRRAVKVAKEAGLVK 89

                          90       100
                  ....*....|....*....|....*
gi 805752161  647 TGDSVVVVTGWRQG-SGFTNTLRVV 670
Cdd:pfam02887  90 KGDLVVITAGVPFGvSGTTNTLKVI 114
Mito_carr pfam00153
Mitochondrial carrier protein;
4-91 3.80e-14

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 68.45  E-value: 3.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752161    4 SGFSGAVGGVLGTPGDVINVRMQNDIKLAPELRRNykhALDGIVCIVQQEGFSKLFSGCTTATLRAALMTIGQLSFYDQI 83
Cdd:pfam00153  12 GGIAGAIAVTVTYPLDVVKTRLQVQGGSGKSKGRG---ILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIYFGTYETL 88


                  ....*...
gi 805752161   84 KITMIESG 91
Cdd:pfam00153  89 KRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
93-153 3.12e-08

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 51.50  E-value: 3.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752161   93 FEDNPVTHVLSSVCAGAVATTLTQPLDVLKTRAMNA---KPGEFKSLMDLFLYTAKL-GPLAFFK 153
Cdd:pfam00153   1 SELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQggsGKSKGRGILDCFKKIYKEeGIRGLYK 65
PRK10558 PRK10558
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
 405-466 1.92e-03

alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional


Pssm-ID: 182547  Cd Length: 256  Bit Score: 40.49  E-value: 1.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 805752161 405 KNIKIISKIENQQGMTNLDEI--IEASDGIMVARGDL-------GIEIPPEkVFLAQKCMISRCNKVGKPV 466
Cdd:PRK10558 144 KNITVLVQIESQQGVDNVDAIaaTEGVDGIFVGPSDLaaalghlGNASHPD-VQKAIQHIFARAKAHGKPS 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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