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Full Results
PREDICTED: pyruvate kinase-like isoform X2 [Megachile rotundata]
Protein Classification
pyruvate kinase ( domain architecture ID 1562468 )
pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis
List of domain hits
Name
Accession
Description
Interval
E-value
Pyruvate_Kinase super family
cl39076 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
4-481
1.88e-115
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
cd00288 :Pssm-ID: 453956 [Multi-domain]
Cd Length: 480
Bit Score: 348.92
E-value: 1.88e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG N A NSHP E AIVEMMM AG A N IV R L N M SH EQEKW H AITVQSI REA gnr MYEYTS diy P LGV A MNLR GPEIRTG I F N G DP ln 83
Cdd:cd00288 10 IG P A TDSV E NLKKLIK AG M N VA R M N F SH GSHEY H QSRIDNV REA --- AEKTGG --- P VAI A LDTK GPEIRTG L F K G GK -- 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rg YAQ LK E G GIVR l VT N D L A KRA G SACCFWIS Y P NL PRVCR PG DK IL I D R G AAI L Q V R - CVRETS LVC K V IK GG IIKDE K 162
Cdd:cd00288 82 -- DIS LK A G DKFL - VT T D P A AKK G TKEKIYVD Y K NL TKDVS PG NT IL V D D G LLS L K V L s KDDDKT LVC E V LN GG VLGSR K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 163 L V Q L MDSIIP LP QI SE T D NEHI R LAADLEC D ILI A NH VR NKRLING I KSR L KQI G AN k VCVM AKI SS Q Q G LE NFDEIL G A 242
Cdd:cd00288 159 G V N L PGTDVD LP AL SE K D KADL R FGVEQGV D MIF A SF VR KASDVLE I REV L GEK G KD - IKII AKI EN Q E G VN NFDEIL E A 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 243 A D A I LLD R KSVEIDVGP E KM FL VE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAVL T GTD GIF L KTG T L 317
Cdd:cd00288 238 S D G I MVA R GDLGVEIPA E EV FL AQ K ML I A KC NLA GKPV itatq ML ESMIY N PRPT R AEVSDV ANAVL D GTD CVM L SGE T A 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 318 NC K QTS E LL K NIDV IC R EAE S A RWQ R EI FN DLSHKIAI P LDPSQ A IIVG A IETCSKSN A A AI I V T TTSGRTA TML S L YRP 397
Cdd:cd00288 318 KG K YPV E AV K AMAR IC L EAE K A LSH R VL FN EMRRLTPR P TSTTE A VAMS A VRAAFELG A K AI V V L TTSGRTA RLV S K YRP 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 398 RC PI V A I TR YGIV AR S L Q LY H G L YP LHYIN P PL c D W SK D MET R IESG VN FLRR K KYI K V GD AIII V S GW RQ G I G F TN CI R 477
Cdd:cd00288 398 NA PI I A V TR NEQT AR Q L H LY R G V YP VLFEE P KP - G W QE D TDA R LKAA VN VAKE K GLL K K GD LVVV V Q GW PV G S G S TN TM R 476
....
gi 805752184 478 I IY V 481
Cdd:cd00288 477 I LT V 480
Name
Accession
Description
Interval
E-value
Pyruvate_Kinase
cd00288 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
4-481
1.88e-115
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain]
Cd Length: 480
Bit Score: 348.92
E-value: 1.88e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG N A NSHP E AIVEMMM AG A N IV R L N M SH EQEKW H AITVQSI REA gnr MYEYTS diy P LGV A MNLR GPEIRTG I F N G DP ln 83
Cdd:cd00288 10 IG P A TDSV E NLKKLIK AG M N VA R M N F SH GSHEY H QSRIDNV REA --- AEKTGG --- P VAI A LDTK GPEIRTG L F K G GK -- 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rg YAQ LK E G GIVR l VT N D L A KRA G SACCFWIS Y P NL PRVCR PG DK IL I D R G AAI L Q V R - CVRETS LVC K V IK GG IIKDE K 162
Cdd:cd00288 82 -- DIS LK A G DKFL - VT T D P A AKK G TKEKIYVD Y K NL TKDVS PG NT IL V D D G LLS L K V L s KDDDKT LVC E V LN GG VLGSR K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 163 L V Q L MDSIIP LP QI SE T D NEHI R LAADLEC D ILI A NH VR NKRLING I KSR L KQI G AN k VCVM AKI SS Q Q G LE NFDEIL G A 242
Cdd:cd00288 159 G V N L PGTDVD LP AL SE K D KADL R FGVEQGV D MIF A SF VR KASDVLE I REV L GEK G KD - IKII AKI EN Q E G VN NFDEIL E A 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 243 A D A I LLD R KSVEIDVGP E KM FL VE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAVL T GTD GIF L KTG T L 317
Cdd:cd00288 238 S D G I MVA R GDLGVEIPA E EV FL AQ K ML I A KC NLA GKPV itatq ML ESMIY N PRPT R AEVSDV ANAVL D GTD CVM L SGE T A 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 318 NC K QTS E LL K NIDV IC R EAE S A RWQ R EI FN DLSHKIAI P LDPSQ A IIVG A IETCSKSN A A AI I V T TTSGRTA TML S L YRP 397
Cdd:cd00288 318 KG K YPV E AV K AMAR IC L EAE K A LSH R VL FN EMRRLTPR P TSTTE A VAMS A VRAAFELG A K AI V V L TTSGRTA RLV S K YRP 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 398 RC PI V A I TR YGIV AR S L Q LY H G L YP LHYIN P PL c D W SK D MET R IESG VN FLRR K KYI K V GD AIII V S GW RQ G I G F TN CI R 477
Cdd:cd00288 398 NA PI I A V TR NEQT AR Q L H LY R G V YP VLFEE P KP - G W QE D TDA R LKAA VN VAKE K GLL K K GD LVVV V Q GW PV G S G S TN TM R 476
....
gi 805752184 478 I IY V 481
Cdd:cd00288 477 I LT V 480
PykF
COG0469 Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
4-481
1.90e-93
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain]
Cd Length: 471
Bit Score: 291.94
E-value: 1.90e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 I G N A NSH PE AIVEMMM AG ANIV RLN M SH EQEKW H AITVQS IREA GNRMY eytsdi Y P LGVAMN L R GP E IRTG I F NGD P L n 83
Cdd:COG0469 11 L G P A SDS PE VLRKLIE AG MDVA RLN F SH GDHEE H RERIEL IREA AKELG ------ R P VAILLD L Q GP K IRTG K F KEG P V - 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rgya Q LK E G GIVR L V T N D LA kra G S A CCFWIS YP N LP RVCR PGD K IL I D R G AAI L Q V RC V RETSL VC K V IK GG IIKDE K L 163
Cdd:COG0469 84 ---- E LK K G DTFT L T T D D VE --- G D A ERVSVT YP E LP EDVK PGD R IL L D D G KIE L R V EE V EGDEV VC E V VN GG VLSSR K G 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 164 V Q L MDSIIP LP QIS E T D N E HIRL A AD L EC D ILIANH VR NKRLINGIKSR L KQI G AN k VCVM AKI SSQQGL EN F DEI LG A A 243
Cdd:COG0469 157 V N L PGVGLS LP ALT E K D R E DLKF A LE L GV D FIALSF VR SAEDVLEAREL L EEA G GR - APII AKI EKPEAV EN L DEI IE A S 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 244 D A I L ----- L drk S VEI dv GP E KMF L VE K VV I G K CMNV GKPV ML A fhvpnc G Q -------- PR ------ I D mnl I ANAVL 304
Cdd:COG0469 236 D G I M vargd L --- G VEI -- PL E EVP L IQ K RI I R K ARRA GKPV IT A ------ T Q mlesmien PR ptraev S D --- V ANAVL 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 305 T GTD GIF L k T G tlnck Q T S ------ E LLKNIDV I CR EAE SARWQ R E I FND L SHK ia IPLDPSQ AI IVG A I E TCSKSN A A A 378
Cdd:COG0469 302 D GTD AVM L - S G ----- E T A vgkypv E AVETMAR I AE EAE KSLDY R R I LDR L RDE -- PERTITD AI ARA A V E LAEDLG A K A 373
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 379 I IVT T T SG R TA TML S L YRP RC PI V A I T RYGIV AR S L Q L YH G L YP LHY inpplc D WSKDMETR IE SG V NF L RRKKYI K V GD 458
Cdd:COG0469 374 I VAF T E SG S TA RRI S R YRP KV PI L A L T PNERT AR R L A L VW G V YP VLV ------ D DVESTDEM IE EA V EA L LEEGLV K P GD 447
490 500
....*....|....*....|....
gi 805752184 459 AII I VS G WRQ G I - G F TN CIRIIY V 481
Cdd:COG0469 448 LVV I TA G VPV G V p G T TN TLKVHR V 471
PTZ00300
PTZ00300 pyruvate kinase; Provisional
23-481
1.73e-76
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain]
Cd Length: 454
Bit Score: 247.27
E-value: 1.73e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 23 NIV R L N M SH EQEKW H AI T VQSI R E A GN rmy E YTSD I ypl GV A MNLR GPEIRTG I F N G dplnr G Y A QLKE G GIVRLV T NDL 102
Cdd:PTZ00300 2 SVA R M N F SH GSHEY H QT T INNV R Q A AA --- E LGVN I --- AI A LDTK GPEIRTG L F V G ----- G E A VMER G ATCYVT T DPA 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 103 AKRA G SACC F W I S Y P NL PR V C RPG DK I L ID R G AA IL Q V RCVR - E TS L V C K V IKGGI I K D EKL V Q L MDSIIP LP QI S ET D N 181
Cdd:PTZ00300 71 FADK G TKDK F Y I D Y Q NL SK V V RPG GY I Y ID D G IL IL H V QSHE d E QT L K C T V TNAHT I S D RRG V N L PGCDVD LP AV S AK D C 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 182 EHIRLAADLEC D ILI A NHV R NKRLINGIKSR L KQI G AN k VCVMA KI SSQ QG LE N F D E I LGAA D A I LLD R KSVEIDVGP EK 261
Cdd:PTZ00300 151 ADLQFGVEQGV D MIF A SFI R SAEQVGEVRKA L GAK G GD - IMIIC KI ENH QG VQ N I D S I IEES D G I MVA R GDLGVEIPA EK 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 262 MFLVE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAV LT G T D GIF L KTG T LNC K QTS E LLKNIDV IC R EA 336
Cdd:PTZ00300 230 VVVAQ K IL I S KC NVA GKPV icatq ML ESMTY N PRPT R AEVSDV ANAV FN G A D CVM L SGE T AKG K YPN E VVQYMAR IC L EA 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 337 E SA RWQREI FN DLSHKIA IP LDPSQ A IIVG A IETCSKSN A A A II V TTTS GR T A TMLSL YRP R CPIV AI T RYGIVA R S L QL 416
Cdd:PTZ00300 310 Q SA VNEYVF FN SIKKLQP IP MSAEE A VCSS A VNSVYETK A K A LV V LSNT GR S A RLVAK YRP N CPIV CV T TRLQTC R Q L NI 389
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752184 417 YH G LYPLHYINPP L CD w SKDM E T R IES GV N F LRR K K Y IKV GD AIII V SGWRQGI G FT N CI RII Y V 481
Cdd:PTZ00300 390 TQ G VESVFFDAER L GH - DEGK E Q R VAM GV G F AKS K G Y VQS GD LMVV V HADHKVK G YA N QT RII L V 453
PK
pfam00224 Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
4-346
1.19e-62
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain]
Cd Length: 348
Bit Score: 207.99
E-value: 1.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG N A NSHP E AIVEMMM AGAN IV R L N M SH EQEKW H AITVQSI REA gnrmyeyt SDIYP -- LGV A MNLR GPEIRTG IFNGDP 81
Cdd:pfam00224 10 IG P A SNSV E NLEKLIE AGAN VA R M N F SH GSHEY H QSRIDNV REA -------- EEKTG gt VAI A LDTK GPEIRTG NTKDGK 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 82 LN rgy AQ LK E G GIVRLV T NDLA K R A GSACCFWIS Y P N LPRVCRP G DK IL I D R G AAI L Q V R - CVRETS LV CK V IK GG I I KD 160
Cdd:pfam00224 82 KD --- IE LK A G DEMIVS T DAKY K G A CDDEMIYVD Y K N IVKDVSV G GT IL V D D G LLS L K V L s KDDDKT LV VE V LN GG V I GS 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 161 E K L V Q L MDSIIP LP QI SE T D NEHI R LAADLEC D ILI A NH VR NKRLING I KSR L KQI G A N k VCVM AKI SS Q Q G LE NFDEIL 240
Cdd:pfam00224 159 R K G V N L PGTDVD LP AL SE K D KADL R FGVKNGV D MIF A SF VR KASDVLE I REV L GEA G K N - IQII AKI EN Q E G VN NFDEIL 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 241 G A A D A I LLD R KSVE I DVGP E KM FL VE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAVL T GTD GIF L KTG 315
Cdd:pfam00224 238 E A T D G I MVA R GDLG I EIPA E EV FL AQ K ML I A KC NLA GKPV itatq ML ESMIY N PRPT R AEVSDV ANAVL D GTD CVM L SGE 317
330 340 350
....*....|....*....|....*....|.
gi 805752184 316 T LNCKQTS E LLKNIDV IC R EAE S A RWQ R EI F 346
Cdd:pfam00224 318 T AKGNYPV E AVRMMHE IC L EAE K A LPH R NL F 348
Name
Accession
Description
Interval
E-value
Pyruvate_Kinase
cd00288 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
4-481
1.88e-115
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain]
Cd Length: 480
Bit Score: 348.92
E-value: 1.88e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG N A NSHP E AIVEMMM AG A N IV R L N M SH EQEKW H AITVQSI REA gnr MYEYTS diy P LGV A MNLR GPEIRTG I F N G DP ln 83
Cdd:cd00288 10 IG P A TDSV E NLKKLIK AG M N VA R M N F SH GSHEY H QSRIDNV REA --- AEKTGG --- P VAI A LDTK GPEIRTG L F K G GK -- 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rg YAQ LK E G GIVR l VT N D L A KRA G SACCFWIS Y P NL PRVCR PG DK IL I D R G AAI L Q V R - CVRETS LVC K V IK GG IIKDE K 162
Cdd:cd00288 82 -- DIS LK A G DKFL - VT T D P A AKK G TKEKIYVD Y K NL TKDVS PG NT IL V D D G LLS L K V L s KDDDKT LVC E V LN GG VLGSR K 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 163 L V Q L MDSIIP LP QI SE T D NEHI R LAADLEC D ILI A NH VR NKRLING I KSR L KQI G AN k VCVM AKI SS Q Q G LE NFDEIL G A 242
Cdd:cd00288 159 G V N L PGTDVD LP AL SE K D KADL R FGVEQGV D MIF A SF VR KASDVLE I REV L GEK G KD - IKII AKI EN Q E G VN NFDEIL E A 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 243 A D A I LLD R KSVEIDVGP E KM FL VE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAVL T GTD GIF L KTG T L 317
Cdd:cd00288 238 S D G I MVA R GDLGVEIPA E EV FL AQ K ML I A KC NLA GKPV itatq ML ESMIY N PRPT R AEVSDV ANAVL D GTD CVM L SGE T A 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 318 NC K QTS E LL K NIDV IC R EAE S A RWQ R EI FN DLSHKIAI P LDPSQ A IIVG A IETCSKSN A A AI I V T TTSGRTA TML S L YRP 397
Cdd:cd00288 318 KG K YPV E AV K AMAR IC L EAE K A LSH R VL FN EMRRLTPR P TSTTE A VAMS A VRAAFELG A K AI V V L TTSGRTA RLV S K YRP 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 398 RC PI V A I TR YGIV AR S L Q LY H G L YP LHYIN P PL c D W SK D MET R IESG VN FLRR K KYI K V GD AIII V S GW RQ G I G F TN CI R 477
Cdd:cd00288 398 NA PI I A V TR NEQT AR Q L H LY R G V YP VLFEE P KP - G W QE D TDA R LKAA VN VAKE K GLL K K GD LVVV V Q GW PV G S G S TN TM R 476
....
gi 805752184 478 I IY V 481
Cdd:cd00288 477 I LT V 480
PykF
COG0469 Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
4-481
1.90e-93
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain]
Cd Length: 471
Bit Score: 291.94
E-value: 1.90e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 I G N A NSH PE AIVEMMM AG ANIV RLN M SH EQEKW H AITVQS IREA GNRMY eytsdi Y P LGVAMN L R GP E IRTG I F NGD P L n 83
Cdd:COG0469 11 L G P A SDS PE VLRKLIE AG MDVA RLN F SH GDHEE H RERIEL IREA AKELG ------ R P VAILLD L Q GP K IRTG K F KEG P V - 83
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rgya Q LK E G GIVR L V T N D LA kra G S A CCFWIS YP N LP RVCR PGD K IL I D R G AAI L Q V RC V RETSL VC K V IK GG IIKDE K L 163
Cdd:COG0469 84 ---- E LK K G DTFT L T T D D VE --- G D A ERVSVT YP E LP EDVK PGD R IL L D D G KIE L R V EE V EGDEV VC E V VN GG VLSSR K G 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 164 V Q L MDSIIP LP QIS E T D N E HIRL A AD L EC D ILIANH VR NKRLINGIKSR L KQI G AN k VCVM AKI SSQQGL EN F DEI LG A A 243
Cdd:COG0469 157 V N L PGVGLS LP ALT E K D R E DLKF A LE L GV D FIALSF VR SAEDVLEAREL L EEA G GR - APII AKI EKPEAV EN L DEI IE A S 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 244 D A I L ----- L drk S VEI dv GP E KMF L VE K VV I G K CMNV GKPV ML A fhvpnc G Q -------- PR ------ I D mnl I ANAVL 304
Cdd:COG0469 236 D G I M vargd L --- G VEI -- PL E EVP L IQ K RI I R K ARRA GKPV IT A ------ T Q mlesmien PR ptraev S D --- V ANAVL 301
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 305 T GTD GIF L k T G tlnck Q T S ------ E LLKNIDV I CR EAE SARWQ R E I FND L SHK ia IPLDPSQ AI IVG A I E TCSKSN A A A 378
Cdd:COG0469 302 D GTD AVM L - S G ----- E T A vgkypv E AVETMAR I AE EAE KSLDY R R I LDR L RDE -- PERTITD AI ARA A V E LAEDLG A K A 373
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 379 I IVT T T SG R TA TML S L YRP RC PI V A I T RYGIV AR S L Q L YH G L YP LHY inpplc D WSKDMETR IE SG V NF L RRKKYI K V GD 458
Cdd:COG0469 374 I VAF T E SG S TA RRI S R YRP KV PI L A L T PNERT AR R L A L VW G V YP VLV ------ D DVESTDEM IE EA V EA L LEEGLV K P GD 447
490 500
....*....|....*....|....
gi 805752184 459 AII I VS G WRQ G I - G F TN CIRIIY V 481
Cdd:COG0469 448 LVV I TA G VPV G V p G T TN TLKVHR V 471
PTZ00300
PTZ00300 pyruvate kinase; Provisional
23-481
1.73e-76
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain]
Cd Length: 454
Bit Score: 247.27
E-value: 1.73e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 23 NIV R L N M SH EQEKW H AI T VQSI R E A GN rmy E YTSD I ypl GV A MNLR GPEIRTG I F N G dplnr G Y A QLKE G GIVRLV T NDL 102
Cdd:PTZ00300 2 SVA R M N F SH GSHEY H QT T INNV R Q A AA --- E LGVN I --- AI A LDTK GPEIRTG L F V G ----- G E A VMER G ATCYVT T DPA 70
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 103 AKRA G SACC F W I S Y P NL PR V C RPG DK I L ID R G AA IL Q V RCVR - E TS L V C K V IKGGI I K D EKL V Q L MDSIIP LP QI S ET D N 181
Cdd:PTZ00300 71 FADK G TKDK F Y I D Y Q NL SK V V RPG GY I Y ID D G IL IL H V QSHE d E QT L K C T V TNAHT I S D RRG V N L PGCDVD LP AV S AK D C 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 182 EHIRLAADLEC D ILI A NHV R NKRLINGIKSR L KQI G AN k VCVMA KI SSQ QG LE N F D E I LGAA D A I LLD R KSVEIDVGP EK 261
Cdd:PTZ00300 151 ADLQFGVEQGV D MIF A SFI R SAEQVGEVRKA L GAK G GD - IMIIC KI ENH QG VQ N I D S I IEES D G I MVA R GDLGVEIPA EK 229
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 262 MFLVE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAV LT G T D GIF L KTG T LNC K QTS E LLKNIDV IC R EA 336
Cdd:PTZ00300 230 VVVAQ K IL I S KC NVA GKPV icatq ML ESMTY N PRPT R AEVSDV ANAV FN G A D CVM L SGE T AKG K YPN E VVQYMAR IC L EA 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 337 E SA RWQREI FN DLSHKIA IP LDPSQ A IIVG A IETCSKSN A A A II V TTTS GR T A TMLSL YRP R CPIV AI T RYGIVA R S L QL 416
Cdd:PTZ00300 310 Q SA VNEYVF FN SIKKLQP IP MSAEE A VCSS A VNSVYETK A K A LV V LSNT GR S A RLVAK YRP N CPIV CV T TRLQTC R Q L NI 389
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752184 417 YH G LYPLHYINPP L CD w SKDM E T R IES GV N F LRR K K Y IKV GD AIII V SGWRQGI G FT N CI RII Y V 481
Cdd:PTZ00300 390 TQ G VESVFFDAER L GH - DEGK E Q R VAM GV G F AKS K G Y VQS GD LMVV V HADHKVK G YA N QT RII L V 453
PRK05826
PRK05826 pyruvate kinase; Provisional
4-465
2.23e-73
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain]
Cd Length: 465
Bit Score: 239.28
E-value: 2.23e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 I G N A NSH PE AIVEMMM AG A N I VRLN M SH EQEKW H AITVQSI RE AGNRMYE ytsdiy P LGVAMN L R GP E IR T G I F NGDPL n 83
Cdd:PRK05826 12 L G P A SDS PE NLEKLIE AG V N V VRLN F SH GSHEE H GKRAALV RE IAAKLGR ------ P VAILLD L K GP K IR V G K F KEGKI - 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rgya Q LK E G GIVR L V T ND la K RA G SACCFWIS Y PN LP RVCR PGD KI L I D R G AAI L Q V RC V RETSLVCK V IK GG IIKDE K L 163
Cdd:PRK05826 85 ---- T LK T G DKFT L D T DQ -- K EE G DKERVGVD Y KG LP KDVK PGD IL L L D D G KLQ L K V VE V DGDEVETE V KN GG PLSNN K G 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 164 VQLMDSIIP LP QIS E T D NEH I RL AA DLEC D ILIANH VR NKRLINGIKSR L KQI G ANKVCVM AKI SSQQGLE N F DEI LG A A 243
Cdd:PRK05826 159 INIPGGGLS LP ALT E K D KAD I KF AA EQGV D YIAVSF VR SAEDVEEARRL L REA G CPHAKII AKI ERAEAVD N I DEI IE A S 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 244 D A I LLD R KSVEIDVGP E KMFLVE K VV I G K CMNV GKPV ----- ML AFHVP N cgq PR ------ I D mnl I ANAVL T GTD GIF L 312
Cdd:PRK05826 239 D G I MVA R GDLGVEIPD E EVPGLQ K KI I R K AREA GKPV itatq ML ESMIE N --- PR ptraev S D --- V ANAVL D GTD AVM L 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 313 KTG T LNC K QTS E LLKNIDV IC RE AE SARWQREIFND L SHKIA ipl DPSQ AI IVG A IET - CSKSNAA AI IVT T T SGRTA TM 391
Cdd:PRK05826 313 SGE T AAG K YPV E AVEAMAR IC KG AE KEFSINLSKHR L DRQFD --- RIDE AI AMS A MYA a NHLKGVK AI VAL T E SGRTA RL 389
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 805752184 392 L S LY RP RC PI V A I TR YGIVA R S L Q LY H G L YP LH yinppl C D WSK D METRI E SGVNF L RR K KYIKV GD AIIIV SG 465
Cdd:PRK05826 390 I S RF RP GA PI F A V TR DEKTQ R R L A LY R G V YP VL ------ F D SAA D TDDAA E EALRL L LE K GLVES GD LVVVT SG 457
PRK06354
PRK06354 pyruvate kinase; Provisional
4-478
1.75e-65
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain]
Cd Length: 590
Bit Score: 222.11
E-value: 1.75e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG N A NSH PE AIVEMMM AGA NIV RLN M SH EQEKW H AITVQS IREA GNRMYE ytsdiy PL G VAMN L R GP E IR T G I F NGD P LN 83
Cdd:PRK06354 16 IG P A SES PE KLRQLIE AGA TTA RLN F SH GDHEE H GARIKN IREA SKKLGK ------ TV G ILQD L Q GP K IR L G R F EDG P IE 89
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rgyaq LK E G GIVR L VTNDLA kra G SACC F WIS Y PN L PRVCRP G DK IL I D R G AAI L Q V RC V -- RETS L V CKV IK GG IIKDE 161
Cdd:PRK06354 90 ----- LK T G DEFI L TSREVL --- G TQEK F SVT Y DG L ADEVPV G SR IL L D D G LIE L E V EE V dk ADGE L H CKV LV GG VLSNK 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 162 K L V QLMDSIIP LP Q I S E T D N E HIRLAADLEC D ILIANH VRN KRLING I KSRLKQIGANKVCVM AKI SS Q QGLE N F D E IL G 241
Cdd:PRK06354 162 K G V NFPGVSLS LP A I T E K D R E DLIFGLEQGV D WIALSF VRN PSDVLE I RELIEEHNGKHIPII AKI EK Q EAID N I D A IL E 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 242 AA D AILLD R KSVEIDVGP E KMF L VE K VV I G K CMNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANA V L T GTD GIF L KTG T 316
Cdd:PRK06354 242 LC D GLMVA R GDLGVEIPA E EVP L LQ K RL I K K ANRL GKPV itatq ML DSMQR N PRPT R AEASDV ANA I L D GTD AVM L SNE T 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 317 LNCKQTS E LLKNIDV I CREA E SARWQ R E I FNDLSH - KIA I PLDP SQA ii V G ai ETCSKSN AAAI IVT T T SG R TA TML S L Y 395
Cdd:PRK06354 322 AAGDYPV E AVQTMAT I AVRI E KDLPY R D I LSKRPE f TTT I TNAI SQA -- V S -- HIALQLD AAAI VTL T K SG A TA RNV S K Y 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 396 RP RC PI V A I T RYGI VAR S LQL YH G LY PL HYINP P LC D wskdm ET r IESGV N FLRRKKYI K V GD AII I VS G WRQ G I - G F T N 474
Cdd:PRK06354 398 RP KT PI L A V T PNES VAR R LQL VW G VT PL LVLDA P ST D ----- ET - FDAAI N VAQESGLL K Q GD LVV I TA G TLV G E s G S T D 471
....
gi 805752184 475 CIRI 478
Cdd:PRK06354 472 LMKV 475
PTZ00066
PTZ00066 pyruvate kinase; Provisional
4-482
6.46e-65
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain]
Cd Length: 513
Bit Score: 218.48
E-value: 6.46e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 I G N A NSHP E AI V EMMM AG A NI V R L N M SH EQEKW H AI T VQSI REA GNRMYEYT sdiyp LG VAMNLR GPEIRTG IF - N GD P L 82
Cdd:PTZ00066 46 M G P A CKNV E TL V KLID AG M NI C R F N F SH GDHES H KK T LNNV REA AKARPNAN ----- LG ILLDTK GPEIRTG FL k N HK P I 120
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 83 nrgya Q LKEG GIVRLV T N dl AKRA G SAC C FWI SY PN LP RVCRP G DK ILI DR G AAILQ V RC V RETSLVC KV IKGGI I KDE K 162
Cdd:PTZ00066 121 ----- T LKEG QTLKIT T D -- YTFL G DET C ISC SY KK LP QSVKV G NI ILI AD G SLSCK V LE V HDDYIIT KV LNNAT I GER K 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 163 LVQ L MDSIIP LP Q I S E T D NEH I - RL A ADLE CD ILIANH V RNKRLINGIKSR L KQI G a NKVCVMA KI SSQQ GL E NFDEIL G 241
Cdd:PTZ00066 194 NMN L PGVKVE LP V I G E K D KND I l NF A IPMG CD FIALSF V QSADDVRLCRQL L GER G - RHIKIIP KI ENIE GL I NFDEIL A 272
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 242 AA D A I LLD R KSVEIDVG PEK M FL VE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAVL T GTD GIF L KTG T 316
Cdd:PTZ00066 273 ES D G I MVA R GDLGMEIP PEK V FL AQ K MM I S KC NVA GKPV itatq ML ESMIK N PRPT R AESTDV ANAVL D GTD CVM L SGE T 352
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 317 L N C K QTS E LLKNIDV IC R EAE SARWQ R EIFNDLSHKIAI P LDPSQ A IIVG A I ET CSKS NA AA II VT T TS G R TA TML S L YR 396
Cdd:PTZ00066 353 A N G K FPV E AVNIMAK IC F EAE TCIDY R VLYHAIHLAVPT P VSVQE A VARS A V ET AEDI NA KL II AL T ET G N TA RLI S K YR 432
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 397 P R C P I V A ITRYGI V AR SL QLYH G L yp LH Y INPPL cdws KDMETR I ESGVNFLRRKKYIKV GD AI I I V S G WRQGI - G FT N C 475
Cdd:PTZ00066 433 P S C T I L A LSASPS V VK SL SVAR G V -- TT Y VVNSF ---- QGTDVV I RNAIALAKERGLVES GD SA I A V H G VKEEV a G SS N L 506
....*..
gi 805752184 476 IRIIYV P 482
Cdd:PTZ00066 507 MKVVKI P 513
PK
pfam00224 Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
4-346
1.19e-62
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain]
Cd Length: 348
Bit Score: 207.99
E-value: 1.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG N A NSHP E AIVEMMM AGAN IV R L N M SH EQEKW H AITVQSI REA gnrmyeyt SDIYP -- LGV A MNLR GPEIRTG IFNGDP 81
Cdd:pfam00224 10 IG P A SNSV E NLEKLIE AGAN VA R M N F SH GSHEY H QSRIDNV REA -------- EEKTG gt VAI A LDTK GPEIRTG NTKDGK 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 82 LN rgy AQ LK E G GIVRLV T NDLA K R A GSACCFWIS Y P N LPRVCRP G DK IL I D R G AAI L Q V R - CVRETS LV CK V IK GG I I KD 160
Cdd:pfam00224 82 KD --- IE LK A G DEMIVS T DAKY K G A CDDEMIYVD Y K N IVKDVSV G GT IL V D D G LLS L K V L s KDDDKT LV VE V LN GG V I GS 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 161 E K L V Q L MDSIIP LP QI SE T D NEHI R LAADLEC D ILI A NH VR NKRLING I KSR L KQI G A N k VCVM AKI SS Q Q G LE NFDEIL 240
Cdd:pfam00224 159 R K G V N L PGTDVD LP AL SE K D KADL R FGVKNGV D MIF A SF VR KASDVLE I REV L GEA G K N - IQII AKI EN Q E G VN NFDEIL 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 241 G A A D A I LLD R KSVE I DVGP E KM FL VE K VV I G KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANAVL T GTD GIF L KTG 315
Cdd:pfam00224 238 E A T D G I MVA R GDLG I EIPA E EV FL AQ K ML I A KC NLA GKPV itatq ML ESMIY N PRPT R AEVSDV ANAVL D GTD CVM L SGE 317
330 340 350
....*....|....*....|....*....|.
gi 805752184 316 T LNCKQTS E LLKNIDV IC R EAE S A RWQ R EI F 346
Cdd:pfam00224 318 T AKGNYPV E AVRMMHE IC L EAE K A LPH R NL F 348
PRK06247
PRK06247 pyruvate kinase; Provisional
4-484
4.39e-58
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain]
Cd Length: 476
Bit Score: 199.38
E-value: 4.39e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 I G N A N S HPEA I VEMMM AGA NIV RLN M SH EQEKW H AITVQS IRE A gnrmyeyt S D IY -- P L G VAMN L R GP EI R T G I F NGDP 81
Cdd:PRK06247 13 L G P A S S SEDM I RKLVE AGA DVF RLN F SH GDHDD H RELYKR IRE V -------- E D ET gr P I G ILAD L Q GP KL R L G R F ADGK 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 82 lnrgy A QL KE G GIV RL vtn D LAKRA G SACCFWISY P NLPRVCR PGD KI L I D R G AAI L Q V RCVRETSL VC K V IK GG IIK D E 161
Cdd:PRK06247 85 ----- V QL AN G QTF RL --- D VDDAP G DHDRVSLPH P EIAAALK PGD RL L V D D G KVR L V V EACDGDDV VC R V VE GG PVS D R 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 162 K L V Q L MDSIIPLPQIS E T D NEHIRL A AD L EC D ILIANH V RNKRLINGI ksrl KQ I GANK V C VMAKI SSQ Q GLENFDE I LG 241
Cdd:PRK06247 157 K G V S L PGTVLSVSALT E K D RADLEF A LE L GV D WVALSF V QRPEDVEEV ---- RK I IGGR V P VMAKI EKP Q AIDRLEA I VE 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 242 A A DAI LLD R KSVEID V GP E KMF L VE K VV I GKCMNV GKPV ----- ML AFHVP N CGQP R IDMNLI A N AVL T G T D GIF L KTG T 316
Cdd:PRK06247 233 A S DAI MVA R GDLGVE V PL E QVP L IQ K RI I RAARRA GKPV vvatq ML ESMIE N PVPT R AEVSDV A T AVL D G A D AVM L SAE T 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 317 LNC K QTS E LLKNIDV I C R EA E sarw QREIFND L S H kia IPLDPSQ A IIVG AI ----- ETCSKSNA AA IIVT T T SG R TA TM 391
Cdd:PRK06247 313 ASG K YPV E AVRTMAR I I R QV E ---- RDPTYPP L I H --- AQRPQPE A TKRD AI syaar DIAERLDL AA LVAY T S SG D TA LR 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 392 LSLY RP RC PI V A I T RYGIV AR S L Q L YH G LYPL hyinpp LC D WSK D METRIESGVNFLRRKKYI K V GD AII IV S G WRQ G I - 470
Cdd:PRK06247 386 AARE RP PL PI L A L T PNPET AR R L A L TW G VHCV ------ VV D DAR D TDDMVRRADRIALAEGFY K R GD RVV IV A G VPP G T p 459
490
....*....|....
gi 805752184 471 G F TN CI RI I Y VPPE 484
Cdd:PRK06247 460 G S TN ML RI A Y IGED 473
PRK09206
PRK09206 pyruvate kinase PykF;
4-478
3.83e-56
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain]
Cd Length: 470
Bit Score: 194.12
E-value: 3.83e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG NANSHP E AIVEMMM AG A N IV RLN M SH EQEKW H AITVQSI R EAGNRMYE ytsdiy PLGVAMNLR GPEIRT G ifngdpln 83
Cdd:PRK09206 10 IG PKTESE E MLTKLLD AG M N VM RLN F SH GDYAE H GQRIKNL R NVMSKTGK ------ KAAILLDTK GPEIRT M -------- 75
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rgya Q L KE G GI V R L V ------- T N D l AKRA G SACCFWIS Y PNLPRVCRP G DKI L I D R G AAILQ V RCVRETSLV CKV IKG G 156
Cdd:PRK09206 76 ---- K L EG G ND V S L K agqtftf T T D - KSVV G NKERVAVT Y EGFTADLSV G NTV L V D D G LIGME V TAITGNEVI CKV LNN G 150
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 157 IIKDE K L V Q L MDSI I P LP QIS E T D NEHIRLAADLEC D ILI A NHV R NKRLING I KSR LK QI G ANKVCVMA KI SS Q Q GL E NF 236
Cdd:PRK09206 151 DLGEN K G V N L PGVS I A LP ALA E K D KQDLIFGCEQGV D FVA A SFI R KRSDVLE I REH LK AH G GENIQIIS KI EN Q E GL N NF 230
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 237 DEIL G A A D A I LLD R KS -- VEI D V gp E KMFLVE K VV I G KC MNVG K P V ----- ML AFHVP N CGQP R IDMNLI ANA V L T GTD G 309
Cdd:PRK09206 231 DEIL E A S D G I MVA R GD lg VEI P V -- E EVIFAQ K MM I E KC NRAR K V V itatq ML DSMIK N PRPT R AEAGDV ANA I L D GTD A 308
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 310 IF L KTGTLNC K QTS E LLKNIDV IC REAESARWQ R EIF N DLSH K IA I pldp SQ A IIV GA I ET CS K SN A AA I I V T T TS G RT A 389
Cdd:PRK09206 309 VM L SGESAKG K YPL E AVSIMAT IC ERTDRVMNS R LES N NDNR K LR I ---- TE A VCR GA V ET AE K LD A PL I V V A T QG G KS A 384
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 390 TMLSL Y R P RCP I V A I T RYGIV AR S L Q L YH G LY P L hyinpplcdwskd METR I E S GVN F L R RK K ------- YIKV GD AIII 462
Cdd:PRK09206 385 RSVRK Y F P DAT I L A L T TNEKT AR Q L V L SK G VV P Q ------------- LVKE I A S TDD F Y R LG K elalqsg LAQK GD VVVM 451
490
....*....|....*.
gi 805752184 463 VSG WRQGI G F TN CIRI 478
Cdd:PRK09206 452 VSG ALVPS G T TN TASV 467
PLN02765
PLN02765 pyruvate kinase
12-479
1.01e-53
pyruvate kinase
Pssm-ID: 215409 [Multi-domain]
Cd Length: 526
Bit Score: 189.11
E-value: 1.01e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 12 E A I VEMMM AG ANIV R LNM S HEQEKW H AI T VQSIRE A GNRMYEYT sdiypl G V AMNLR GPE IRT gifngdp L N RGYAQ -- L 89
Cdd:PLN02765 44 E V I EACLK AG MSVA R FDF S WGDAEY H QE T LENLKI A VKNTKKLC ------ A V MLDTV GPE LQV ------- I N KTEKP is L 110
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 90 K E G GI V R L v T N D LA K R A g S ACCFW I SY P N L PRVCR PGD K I LI -------- DRGAAI L Q V RC V RETSL VC K V IKGGIIKDE 161
Cdd:PLN02765 111 K A G NT V T L - T P D QS K E A - S SEVLP I NF P G L AKAVK PGD T I FV gqylftgs ETTSVW L E V DE V KGDDV VC T V KNSATLAGS 188
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 162 KLVQLMDSI - I P LP QI SE T D N E H I R - LAADLEC D I L IANHV R NKRLINGIKSR L KQI G ANKVCVM AKI SSQQ GL EN FDEI 239
Cdd:PLN02765 189 LFTLHVSQV r I D LP TL SE K D K E V I S t WGVPNKI D F L SLSYT R HAEDVREAREF L SSL G LSQTQIF AKI ENVE GL TH FDEI 268
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 240 L GA AD A I L L D R KSVE ID VG PEK M FL VE K VVIG KC MNV GKP VMLAFH V ---- P N CGQP R IDMNLI ANAVL T G T D G I F L KTG 315
Cdd:PLN02765 269 L QE AD G I I L S R GNLG ID LP PEK V FL FQ K AALY KC NMA GKP AVVTRV V dsmt D N LRPT R AEATDV ANAVL D G A D A I L L GAE 348
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 316 TL NCKQTS E LLKNIDV IC R EAE SARW Q REI F NDLSHKIAI P LDPSQA I IVG A IETCS K SN A AA IIV T T T SGR T A TMLSL Y 395
Cdd:PLN02765 349 TL RGLYPV E TISTVGR IC A EAE KVFN Q DLY F KKTVKYVGE P MSHLES I ASS A VRAAI K VK A SV IIV F T S SGR A A RLIAK Y 428
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 396 RP RC P IVAI ------------ TRY G IV - AR SLQLYH GL Y P L h YIN P -- PLCDW S KDM E TRIESGVNFLRRKKY IK VG D AI 460
Cdd:PLN02765 429 RP TM P VLSV viprlktnqlkw SFT G AF q AR QCLIVR GL F P M - LAD P rh SAEST S ATN E SVLKVALDHGKAAGV IK SH D RV 507
490
....*....|....*....
gi 805752184 461 IIV sgwr Q GI G FTNCIR II 479
Cdd:PLN02765 508 VVC ---- Q KV G DSSVVK II 522
PLN02461
PLN02461 Probable pyruvate kinase
12-482
1.84e-53
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain]
Cd Length: 511
Bit Score: 187.88
E-value: 1.84e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 12 EAIVEMMM AG A N IV R L N M SH EQEKW H AI T VQSI R E A GN rmyey TSD I y PLG V AMNLR GPEIRTG IF - N G D P L nrgya QLK 90
Cdd:PLN02461 37 PMLEKLLR AG M N VA R F N F SH GSHEY H QE T LDNL R Q A MA ----- NTG I - LCA V MLDTK GPEIRTG FL k D G K P V ----- QLK 105
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 91 E G GIVRLV T NDLA K ra G SACCFWI SY PN L PRVCR PG DK IL IDR G AAI L Q V - R C VR E TSL V - C KVIKGGIIKDE K L V Q L MD 168
Cdd:PLN02461 106 Q G QEITIT T DYSI K -- G DENMIAM SY KK L AVDVK PG SV IL CAD G TIT L T V l S C DV E AGT V r C RCENSAMLGER K N V N L PG 183
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 169 SIIP LP QIS E T D N E H I rlaad L E ------ C D ILIANH VR NKRLINGIKSR L KQ i G A NKVCVMA K ISS Q Q GL E NFD E IL GA 242
Cdd:PLN02461 184 VVVD LP TLT E K D K E D I ----- L Q wgvpnk I D FIALSF VR KGSDLVEVRKV L GE - H A KSILLIS K VEN Q E GL D NFD D IL AE 257
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 243 A DA ILLD R KSVEIDVGP EK M FL VE K VV I G KC MNV GKPV ----- ML AFHVPNCGQP R IDMNLI ANAVL T GTD GIF L KTG T L 317
Cdd:PLN02461 258 S DA FMVA R GDLGMEIPI EK I FL AQ K MM I Y KC NLA GKPV vtatq ML ESMIKSPRPT R AEATDV ANAVL D GTD CVM L SGE T A 337
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 318 NCKQTSELL K NIDV ICREAE SARWQREI F NDLSHKIAI P LD P SQAIIVG A IE T CS K SN A AA I I V T T TS G R TA TMLSL YRP 397
Cdd:PLN02461 338 AGAYPELAV K TMAR ICREAE ASLDYGAL F KEIMRSAPL P MS P LESLASS A VR T AN K VK A SL I V V L T RG G T TA RLVAK YRP 417
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 398 RC PI VA ----- IT RYGI -------- V AR SLQL Y H GL Y P LHYINPPLCDW S KDM E TRI E SGVNFLRR K KYI K V GD AIIIV s 464
Cdd:PLN02461 418 AV PI LS vvvpe IT TDSF dwscsdea P AR HSLI Y R GL I P VLAEGSAKATD S EST E EIL E AAIEHAKK K GLC K P GD SVVAL - 496
490
....*....|....*...
gi 805752184 465 gwr QG IG FTNC I R I IY V P 482
Cdd:PLN02461 497 --- HR IG GASV I K I LT V K 511
PLN02623
PLN02623 pyruvate kinase
4-470
8.36e-38
pyruvate kinase
Pssm-ID: 215334 [Multi-domain]
Cd Length: 581
Bit Score: 146.23
E-value: 8.36e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG NANSHP E A I VEMMM AG A N IV RLNMSH EQEKW H AITVQSIR E agnrm Y EYT S DIYPLGVAMNLR GPE I R T G IFN g D P L n 83
Cdd:PLN02623 118 IG PSTNTR E M I WKLAE AG M N VA RLNMSH GDHAS H QKVIDLVK E ----- Y NAQ S KDNVIAIMLDTK GPE V R S G DLP - Q P I - 190
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rgya Q L K EG giv RLV T NDLAKRAGSAC C FWIS Y PNLPRVCRP GD KI L I D R G AAI L Q V RCVRET S LV C K V IK GG II K DEKL 163
Cdd:PLN02623 191 ---- M L E EG --- QEF T FTIKRGVSTED C VSVN Y DDFVNDVEV GD ML L V D G G MMS L A V KSKTSD S VK C E V VD GG EL K SRRH 263
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 164 VQLMDSIIP LP Q I S E T D N E H I RLAADLEC D ILIANH V RNKRLINGI K SR LK QIG A N k VC V MA KI S S QQGLE N FDE I LG A A 243
Cdd:PLN02623 264 LNVRGKSAT LP S I T E K D W E D I KFGVENKV D FYAVSF V KDAQVVHEL K DY LK SCN A D - IH V IV KI E S ADSIP N LHS I IT A S 342
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 244 D AILLD R KSVEIDVGP E KMF L VEKVV I GK C MNV GKPV ----- ML AFHVPNCGQP R IDMNL IA N AV LT G T D GIF L KTG T LN 318
Cdd:PLN02623 343 D GAMVA R GDLGAELPI E EVP L LQEEI I RR C RSM GKPV ivatn ML ESMIVHPTPT R AEVSD IA I AV RE G A D AVM L SGE T AH 422
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 319 C K QTSELL K NIDVICREA E SARWQREIFND L SH ki A IPLDP S QAIIVG A i ETCSKSNAAA IIV T T TS G RT A TM LS L YRP R 398
Cdd:PLN02623 423 G K FPLKAV K VMHTVALRT E ATLPEGTTPPN L GQ -- A FKNHM S EMFAFH A - TMMANTLGTS IIV F T RT G FM A IL LS H YRP S 499
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 805752184 399 CP I V A I T RYGIVARS L Q LY H G LY P LHY inpplc DW S K D M E TRIESGVNF L RR K KYI K V G DAIII V SGW RQ G I 470
Cdd:PLN02623 500 GT I F A F T NEKRIQQR L A LY Q G VC P IYM ------ QF S D D A E ETFARALSL L LN K GMV K E G EEVAL V QSG RQ P I 565
PLN02762
PLN02762 pyruvate kinase complex alpha subunit
4-464
2.05e-34
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain]
Cd Length: 509
Bit Score: 135.26
E-value: 2.05e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 4 IG N A NSHP E AIVEMM M A G A N IV RLNM S H EQEK WH AITVQSI R eagn R MY E YTS di YPLG V A M NLR G P EI RT G IFN G DP ln 83
Cdd:PLN02762 33 IG P A CCGF E QLEALA M G G M N VA RLNM C H GTRE WH RDVIRRV R ---- R LN E EKG -- FAVA V M M DTE G S EI HM G DLG G AS -- 104
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 84 rgy AQLK E G G IVRLV T NDLAKRAGSACCFWIS Y PNLPRVCRP GD KILI D R G AAILQ V RCVRETSLV CK VIKG G II ----- 158
Cdd:PLN02762 105 --- SAKA E D G EEWTF T VRKFDGSRPEFTIQVN Y DGFAEDVKV GD ELVV D G G MVRFE V IEKIGPDVK CK CTDP G LL lpran 181
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 159 ---- K D EK LV Q lm DSIIP LP Q IS ET D NEH I RLAADLEC D ILIANH V RNKRL I NGI KS RLKQIGAN - KVC V M AKI S S QQG L 233
Cdd:PLN02762 182 ltfw R D GS LV R -- ERNAM LP T IS SK D WLD I DFGISEGV D FIAVSF V KSAEV I KHL KS YIAARSRD s DIG V I AKI E S LDS L 259
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 234 E N FD EI LG A A D AILLD R KSVEIDVGP E KMFL V EKVVIGK C MNVG KPV --------- M LAFHV P N cgqp R IDMNLIAN AV L 304
Cdd:PLN02762 260 K N LE EI IR A S D GAMVA R GDLGAQIPL E QVPS V QEKIVRL C RQLN KPV ivasqlles M IEYPT P T ---- R AEVADVSE AV R 335
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 305 TGT D GIF L K ---- T G TLNC K QT S E L LK --- NIDVIC RE A -- ES A RWQREIFND LS HK I aipldp S QA I IVG A IETCSKSN 375
Cdd:PLN02762 336 QRA D ALM L S gesa M G LYPE K AL S V L RS vsl RMELWS RE E kr HE A LELPQLSSS LS DR I ------ S EE I CNS A AKMANNLG 409
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 376 AA AI I V T T TS G RT A TM LS LY RP R CPI V A I T RYGI V A R S L Q L YH GL Y P LHY inpplc D W S K DME TRIESGVNF L RRKKY IK 455
Cdd:PLN02762 410 VD AI F V Y T KH G HM A SL LS RN RP D CPI F A F T DTTS V R R R L N L QW GL I P FRL ------ D F S D DME SNLNKTFSL L KARGM IK 483
....*....
gi 805752184 456 V GD AI I I VS 464
Cdd:PLN02762 484 S GD LV I A VS 492
PK_C
pfam02887 Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
361-479
5.42e-32
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain]
Cd Length: 114
Bit Score: 118.74
E-value: 5.42e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 361 Q AI IVG A I E TCSKSN A A AI I V T T T SG R TA TML S L YRP RC PI V A I T RYGIV AR S L Q LY H G L YP LHYINP plcdws KDMETR 440
Cdd:pfam02887 1 E AI AHA A V E AAEELG A K AI V V L T E SG Y TA RLI S R YRP GV PI I A V T PNELT AR Q L A LY W G V YP VLFDEA ------ ETTDEM 74
90 100 110 120
....*....|....*....|....*....|....*....|
gi 805752184 441 IESG V NFLRRKKYI K V GD AII I VS G WRQ G I - G F TN CIRI I 479
Cdd:pfam02887 75 LRRA V KVAKEAGLV K K GD LVV I TA G VPF G V s G T TN TLKV I 114
PykA2
COG3848 Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
272-481
1.62e-17
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058
Cd Length: 321
Bit Score: 83.41
E-value: 1.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 272 KC MNV GKPV ----- ML AFHVP N CGQP R IDMNLI ANA VLT GTD G I F L KTG T LNC K QTS E LLKNIDV I CRE AE SARWQ RE IF 346
Cdd:COG3848 1 KC NAA GKPV itatq ML DSMMR N PRPT R AEAADV ANA IFD GTD A I M L SGE T AAG K YPV E AVVTMVR I AER AE EDLEY RE QR 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 347 N dl SHKIAIPLDPSQ AI IVGAIE T CSKSN AAAII VT T T SG R TA T M L S L YRP RC PI V A I T RYGI VAR S L Q L YH G L YPL hyi 426
Cdd:COG3848 81 V -- PRAKESSTTITD AI SHAVAT T AADLG AAAII TA T E SG A TA R M V S K YRP KA PI I A V T PSER VAR Q L S L VW G V YPL --- 155
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 805752184 427 npp L CDW S KDMETRIESG V NFLRRKKYI K V GD AII I VS G WRQ G I - G F TN CIRIIY V 481
Cdd:COG3848 156 --- L VEE S ASTDEMFAVA V ALALEAGLV K D GD LVV I TA G VPV G V s G T TN LLKVHV V 208
PRK08187
PRK08187 pyruvate kinase; Validated
7-243
2.51e-12
pyruvate kinase; Validated
Pssm-ID: 236178
Cd Length: 493
Bit Score: 68.89
E-value: 2.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 7 A NSH P EAIVEMMMA G ANIV R L N MS H EQEK - W H A I t VQSI R E A ---- G N R M yeytsdiypl GVA M N L R GP E IRTG - IFNGD 80
Cdd:PRK08187 145 A ADD P DFVLRLAER G MDCA R I N CA H DDPA a W Q A M - IGHL R Q A erat G R R C ---------- KIL M D L A GP K IRTG a VAGPL 213
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 81 PLN R gyaq L KE G GIVR LV T n DLAK R AGSACC F WI -- SY P N - L P R V c RP G DKIL ID R G AAILQ V RC V RETSLVCK V I ---- 153
Cdd:PRK08187 214 GKT R ---- L YT G DRLA LV A - QGPP R RIDEEH F QV tc TL P E i L A R L - AV G ARVW ID D G KLGAR V ER V GPGGALLE V T harp 287
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752184 154 KG GII K D EK LVQLM D SIIP LP QIS E T D NEHIRLA A D l EC D ILIANH V RN ---- KR L INGIKS R L k QIGAN K VCVMA KI SS 229
Cdd:PRK08187 288 KG LKL K P EK GLNFP D TALD LP ALT E K D RADLDFV A R - HA D LVGYSF V QS pgdv EA L QAALAA R R - PDDWR K LGLVL KI ET 365
250
....*....|....
gi 805752184 230 QQGLE N FD E ILGA A 243
Cdd:PRK08187 366 PRAVA N LP E LIVQ A 379
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
