BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlfsvkeILQKDLSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAAL----------------------LKETPPDEHPVIILPDVPYSELKALLDF 58

                         90       100
                 ....*....|....*....|....*..
gi 805827545 112 MYCGETTVPYQLLSSLLTATKTFKVKE 138
Cdd:cd18315   59 IYTGEVNVSQEQLESLLKLAELLQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlfsvkeILQKDLSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAAL----------------------LKETPPDEHPVIILPDVPYSELKALLDF 58

                         90       100
                 ....*....|....*....|....*..
gi 805827545 112 MYCGETTVPYQLLSSLLTATKTFKVKE 138
Cdd:cd18315   59 IYTGEVNVSQEQLESLLKLAELLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545    34 DVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTCEEHlfsvkeilqkdlSQEPIIFLKDLNFEILKAMVEFMY 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFK---------ALFSSDFKE------------SDKSEIYLDDVSPEDFRALLNFLY 59

                           90       100       110
                   ....*....|....*....|....*....|....
gi 805827545   114 CGETTVPYQLLSSLLTATKTFKVKELTSVVDAMM 147
Cdd:smart00225  60 TGKLDLPEENVEELLELADYLQIPGLVELCEEFL 93

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlfsvkeILQKDLSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAAL----------------------LKETPPDEHPVIILPDVPYSELKALLDF 58

                         90       100
                 ....*....|....*....|....*..
gi 805827545 112 MYCGETTVPYQLLSSLLTATKTFKVKE 138
Cdd:cd18315   59 IYTGEVNVSQEQLESLLKLAELLQIKG 85

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545   23 FSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTCEEhlfsvkeilqkDLSQEPIIfLKDLNF 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFK---------ALFSGQES-----------ESSVSEIT-LDDVSP 59

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 805827545  103 EILKAMVEFMYCGETTVPYQLLSSLLTATKtFKVKELT 140
Cdd:pfam00651  60 EDFEALLEFMYTGKLISEENVDDLLAAADK-LQIPSLV 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  23 FSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHlkkpclmdiLFTTceehlfSVKEILQKDlsqepiIFLKDLNF 102
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHA---------MFTH------DMVESKQDE------ITMQGIEP 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 805827545 103 EILKAMVEFMYCGETTVPYQLLSSLLTATKTFkvkELTSVVDA 145
Cdd:cd18247   69 SALEALINFAYSGRIAIDTSNVQSLLVGASFL---QLQSVKDA 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  25 ELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpCLMdilFTTceehlfSVKEILQKdlsqepIIFLKDLNFEI 104
Cdd:cd18238    8 QFYENGELCDVTLKVGEKSIHCHRLVLACVSPYF------RAM---FTS------EMAESKQD------SITIKDIDEEA 66

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 805827545 105 LKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18238   67 VELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHlkkpclmdiLFTTceehlfSVKEilqkdlSQEPI 94
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRA---------MFTG------GMRE------SSQDE 59

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 805827545  95 IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTA 130
Cdd:cd18255   60 IELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLGA 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFT--TCEehlfsvkeilqKDLSQe 92
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFK---------AMFTgnLSE-----------KENSE- 59

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 805827545  93 piIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELT 140
Cdd:cd18257   60 --VEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  28 ARQaLVDVTLVCEGQKLRVHKLVLASNSTYfehlkkpclmdilfttceehLFsvkEILQKDLSQEPIIF--LKDLNFEIL 105
Cdd:cd18306   15 NRQ-FCDVILQVGGHEIPAHRAVLACASPY--------------------LF---ELFSSDSDGESILTvkLDGLDPDAV 70

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 805827545 106 KAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18306   71 EVLVNYAYTSRLEVPADLVKSVYSAAKKLKMDRVKKA 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  23 FSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdiLFTTCEEHlfSVKEILQKDLsqEPIIFlkdlnf 102
Cdd:cd18280    5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSM--------LFGPMREE--NEGEIVIEDV--EPPVF------ 66

                         90
                 ....*....|.
gi 805827545 103 eilKAMVEFMY 113
Cdd:cd18280   67 ---KALLHFIY 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  32 LVDVTLVCEGQKLRVHKLVLASNSTYFehlKKpcLMDILFTTceehlfsvkeilqkdlSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18297   12 MSDVTFLVEGRPFYAHKIVLVTASDRF---KS--MLSSGSTE----------------AQTPVIEIPDIRYDIFQLMMQY 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 805827545 112 MYCG---ETTVPYQLLSSLLTATKTFKVKEL 139
Cdd:cd18297   71 LYTGgveSLDVAQDDALELLRAASFFQLDGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpclmdilfttceEHLFSVKEIlqkdLSQEPI 94
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYF-----------------KNAFSSQEI----WISSHV 59

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 805827545  95 IFLKDLNFEILKAMVEFMYCGETTVPYQ-LLSSLLTATKTFKVKELTSVVDA 145
Cdd:cd18223   60 LELPDLKAEVFAEILNFIYSSKVVVKRQeTVTDLVAAGKKLGITFLENLTDQ 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  25 ELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTT--CEEHLFSVKeilqkdlsqepiifLKDLNF 102
Cdd:cd18237   14 NMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFH---------LMFTSnmTESKSSEVE--------------LKDAEP 70

                         90       100       110
                 ....*....|....*....|....*....|....
gi 805827545 103 EILKAMVEFMYCGETTVPYQLLSSLLTATKTFKV 136
Cdd:cd18237   71 DIIELLVEFAYTARISVNSNNVQSLLDAANQYQI 104

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  21 EKFSELLARQALVDVTLVC-EGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlFSVKEILQKDlsqepiiflKD 99
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADL-----------------FLMMTVVTLD---------SD 54

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 805827545 100 LNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSVV 143
Cdd:cd18299   55 ITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMC 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 805827545  14 GHARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHL 61
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFREL 48

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYF 58
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLF 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpclmdilfttceeHLFSvkeilqKDLSQEPI 94
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFF------------------YKFF------QDFTQEPL 56

                         90       100
                 ....*....|....*....|....*
gi 805827545  95 IFLKDLNFEILKAMVEFMYCGETTV 119
Cdd:cd18221   57 VEIEGVSNMAFRHLIEFTYTAKLMV 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTceehlfSVKEILQKDLSQEPI 94
Cdd:cd18336    2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFA---------AMFTN------DVREAKQEEIKMEGV 66

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 805827545  95 iflkdlNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18336   67 ------DPDALKALVHYAYTGVLELKEDTIESLLAAACLLQLSQVIDV 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTceehlfsvkEILQKDLSQepi 94
Cdd:cd18244   13 HDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFR---------IMFTA---------DMRERDQDK--- 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 805827545  95 IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKEL 139
Cdd:cd18244   72 IHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEV 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  13 AGHARFITEKFSELLARQALVDVTLVC-EGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTceehlfSVKEILQKdlsq 91
Cdd:cd18252    2 SSHPADFLDAFRTFYLDGLFTDITLQCaSGQIFHCHKAALAACSSYFK---------VMFTA------DMKEKSNN---- 62

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 805827545  92 epIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTA 130
Cdd:cd18252   63 --VIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEA 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLKKPCLMDilfttceehlfsvkeilqkdlSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18261   28 LCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVE---------------------SEADEVNLHGVTSLGLKQALDF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 805827545 112 MYCGETTVPYQLLSSLLTATKTFKVKELTSVVDAMMTSGIENF 154
Cdd:cd18261   87 AYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSF 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  30 QALVDVTLVCEGQKLRVHKLVLASNSTYFEHLKKPCLMDIlfttceehlfSVKEILQKDLSqepiiflkDLNFEILKAMV 109
Cdd:cd18258   15 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDS----------GGGEKLELTMS--------NINADVLELLL 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 805827545 110 EFMYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18258   77 EFVYTGSLIIDSANAKTLLEAANKFQFHTFCKV 109

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  34 DVTLVCEGQKLRVHKLVLASNSTYFEHLKKPClmdilFTTCeehlfSVKEILQKDlsQEPIIFlkdlnfeilKAMVEFMY 113
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGS-----MIES-----NLKEVTLED--VEPEIF---------ETVLKYMY 66

                         90       100
                 ....*....|....*....|....*.
gi 805827545 114 CGETTVPYQLLSSLLTATKTFKVKEL 139
Cdd:cd18314   67 TGQVTLSEENVLDLLMLASKYQVPDL 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  19 ITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpclmDILFttceEHlfsvkeilQKDLSQEPIIFLK 98
Cdd:cd18343    8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVF---------NAMF----EH--------EMEESKKNRVEIN 66

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 805827545  99 DLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSVVDAMMTSG--IEN 153
Cdd:cd18343   67 DVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNlsVEN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilftTCEehlfsvkeiLQKDLSQEPI 94
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTL-----------YCQ---------VQKTSDQATV 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 805827545  95 IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFkvkELTSVVDA 145
Cdd:cd18230   64 THLDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYL---QMTDIVQA 111

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20
                 ....*....|....*....|....*.
gi 805827545  34 DVTLVCEGQKLRVHKLVLASNSTYFE 59
Cdd:cd18309   22 DITLLLDGHPIPAHKAILAARCSYFE 47

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  21 EKFSELLA-----RQA--LVDVTLVCEGQKLRVHKLVLASNSTYFehlKKpclmdiLFTTCEEHLFSVKEILQKDLSQep 93
Cdd:cd18327    7 EHSSELLSclneqRRAglLCDLTIKTRGLEYRTHRAVLAACSLYF---RK------LFTGGGGGSGDLGAGGGQDVCE-- 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 805827545  94 iiflkdLNF---EILKAMVEFMYCGETTVPYQLLSSLLTATktfKVKELTSVVDAMM 147
Cdd:cd18327   76 ------LDFvgpEALGALLEFAYTATLTISSSNMREVLRAA---RLLEIPCVADACA 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827545  15 HARFITekFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTceehlfsvkEILQkdlSQEPI 94
Cdd:cd18246   24 HDAFVS--MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFH---------AMFTN---------EMSE---SRQTH 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 805827545  95 IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFkvkELTSVVDA 145
Cdd:cd18246   81 VTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLL---QLNGVRDA 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 805827545  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYF 58
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFF 45