BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlfsvkeILQKDLSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAAL----------------------LKETPPDEHPVIILPDVPYSELKALLDF 58

                         90       100
                 ....*....|....*....|....*..
gi 805827552 112 MYCGETTVPYQLLSSLLTATKTFKVKE 138
Cdd:cd18315   59 IYTGEVNVSQEQLESLLKLAELLQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlfsvkeILQKDLSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAAL----------------------LKETPPDEHPVIILPDVPYSELKALLDF 58

                         90       100
                 ....*....|....*....|....*..
gi 805827552 112 MYCGETTVPYQLLSSLLTATKTFKVKE 138
Cdd:cd18315   59 IYTGEVNVSQEQLESLLKLAELLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552    34 DVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTCEEHlfsvkeilqkdlSQEPIIFLKDLNFEILKAMVEFMY 113
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFK---------ALFSSDFKE------------SDKSEIYLDDVSPEDFRALLNFLY 59

                           90       100       110
                   ....*....|....*....|....*....|....
gi 805827552   114 CGETTVPYQLLSSLLTATKTFKVKELTSVVDAMM 147
Cdd:smart00225  60 TGKLDLPEENVEELLELADYLQIPGLVELCEEFL 93

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlfsvkeILQKDLSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAAL----------------------LKETPPDEHPVIILPDVPYSELKALLDF 58

                         90       100
                 ....*....|....*....|....*..
gi 805827552 112 MYCGETTVPYQLLSSLLTATKTFKVKE 138
Cdd:cd18315   59 IYTGEVNVSQEQLESLLKLAELLQIKG 85

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552   23 FSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTCEEhlfsvkeilqkDLSQEPIIfLKDLNF 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFK---------ALFSGQES-----------ESSVSEIT-LDDVSP 59

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 805827552  103 EILKAMVEFMYCGETTVPYQLLSSLLTATKtFKVKELT 140
Cdd:pfam00651  60 EDFEALLEFMYTGKLISEENVDDLLAAADK-LQIPSLV 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  23 FSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHlkkpclmdiLFTTceehlfSVKEILQKDlsqepiIFLKDLNF 102
Cdd:cd18247   10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHA---------MFTH------DMVESKQDE------ITMQGIEP 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 805827552 103 EILKAMVEFMYCGETTVPYQLLSSLLTATKTFkvkELTSVVDA 145
Cdd:cd18247   69 SALEALINFAYSGRIAIDTSNVQSLLVGASFL---QLQSVKDA 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  25 ELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpCLMdilFTTceehlfSVKEILQKdlsqepIIFLKDLNFEI 104
Cdd:cd18238    8 QFYENGELCDVTLKVGEKSIHCHRLVLACVSPYF------RAM---FTS------EMAESKQD------SITIKDIDEEA 66

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 805827552 105 LKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18238   67 VELLVDFAYTGKLTLTVDNVQSLLYAASLLQVEEVAKA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHLKKPCLmdilfttCEEHlfsvKEILQkdlsqepi 94
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGM-------SESS----KDVVQ-------- 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 805827552  95 ifLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFkvkELTSVVDA 145
Cdd:cd18256   64 --IHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADML---QLTEVVEI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFT--TCEehlfsvkeilqKDLSQe 92
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFK---------AMFTgnLSE-----------KENSE- 59

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 805827552  93 piIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELT 140
Cdd:cd18257   60 --VEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAANLLQIKLVL 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  35 VTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmDILFTTCEEhlfsvkeilqkDLSQEpiIFLKDLNFEILKAMVEFMYC 114
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFR--------ALFRGGFRE-----------SGQAE--INLRDISPEDFRALLEFLYG 59

                         90
                 ....*....|....
gi 805827552 115 GETTVPYQLLSSLL 128
Cdd:cd01165   60 GKRDLDASNLLELL 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  23 FSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdiLFTTCEEHlfSVKEILQKDLsqEPIIFlkdlnf 102
Cdd:cd18280    5 FGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSM--------LFGPMREE--NEGEIVIEDV--EPPVF------ 66

                         90
                 ....*....|.
gi 805827552 103 eilKAMVEFMY 113
Cdd:cd18280   67 ---KALLHFIY 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclMDILFTTceehlfsvkeilqkdlSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18297   12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSM-----LSSGSTE----------------AQTPVIEIPDIRYDIFQLMMQY 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 805827552 112 MYCG---ETTVPYQLLSSLLTATKTFKVKEL 139
Cdd:cd18297   71 LYTGgveSLDVAQDDALELLRAASFFQLDGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpclmdilfttceEHLFSVKEIlqkdLSQEPI 94
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYF-----------------KNAFSSQEI----WISSHV 59

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 805827552  95 IFLKDLNFEILKAMVEFMYCGETTVPYQ-LLSSLLTATKTFKVKELTSVVDA 145
Cdd:cd18223   60 LELPDLKAEVFAEILNFIYSSKVVVKRQeTVTDLVAAGKKLGITFLENLTDQ 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  26 LLARQALVDVTLVC--EGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlFSVKeiLQKDLSQEPIIfLKDLNFE 103
Cdd:cd18294    8 LINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAM-----------------FLTG--PQKESTQSPLV-LSDIEPE 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 805827552 104 ILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSVVDAMM 147
Cdd:cd18294   68 VFRAVLEFIYTNCVTLSNHTVIEVLAAAVEYGLDELRKLCERFI 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYF 58
Cdd:cd18215    2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLF 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpCLMdilFT--TCEehlfsvkeilqkdlSQE 92
Cdd:cd18339    4 HMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYF------CAM---FTgdMSE--------------SKA 60

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 805827552  93 PIIFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18339   61 KKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQN 110

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  21 EKFSELLARQALVDVTLVC-EGQKLRVHKLVLASNSTYFEHLkkpclmdilfttceehlFSVKEILQKDlsqepiiflKD 99
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADL-----------------FLMMTVVTLD---------SD 54

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 805827552 100 LNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSVV 143
Cdd:cd18299   55 ITPEAFRRVLEFLYTGVLDENEDDLKELKDAAELLELFDLVMMC 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  19 ITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpclmDILFttceEHlfsvkEILQKDLSQEPIiflK 98
Cdd:cd18345    5 LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVF---------NAMF----EH-----EMEERKQNRVEI---T 63

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 805827552  99 DLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKEL 139
Cdd:cd18345   64 DVDHEVMREMLRFIYTGKAPNLDKMADDLLAAADKYALERL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFehlkkpclmdilfttceeHLFSvkeilqKDLSQEPI 94
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFF------------------YKFF------QDFTQEPL 56

                         90       100
                 ....*....|....*....|....*
gi 805827552  95 IFLKDLNFEILKAMVEFMYCGETTV 119
Cdd:cd18221   57 VEIEGVSNMAFRHLIEFTYTAKLMV 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 805827552  32 LVDVTLVCEGQKLRVHKLVLASNSTYF-EHLKKPCLMDILFTTCEE 76
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFlSRVVGQTDGDLVITLPEE 46

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  24 SELLARQALVDVTLVCEGQKLRV----HKLVLASNSTYFEhlkkpclmdILFTT-CEEHLFSVKEIlqkdlsqepiiflK 98
Cdd:cd18248   13 NELRLSQQLCDVTLKVKYQDPKEefmaHKVVLASSSPYFK---------AMFTSgLRECGMEVVPI-------------E 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 805827552  99 DLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVkelTSVVDA 145
Cdd:cd18248   71 GVHPCVMSRLIEFAYTASISVGEKCVLHVLPGAVMYQM---DSVVKA 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  32 LVDVTLVCEGQKLRVHKLVLASNSTYFEHLKKPCLMDilfttceehlfsvkeilqkdlSQEPIIFLKDLNFEILKAMVEF 111
Cdd:cd18261   28 LCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVE---------------------SEADEVNLHGVTSLGLKQALDF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 805827552 112 MYCGETTVPYQLLSSLLTATKTFKVKELTSVVDAMMTSGIENF 154
Cdd:cd18261   87 AYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSF 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  30 QALVDVTLVCEGQKLRVHKLVLASNSTYFEHLKKPCLMDIlfttceehlfSVKEILQKDLSqepiiflkDLNFEILKAMV 109
Cdd:cd18258   15 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDS----------GGGEKLELTMS--------NINADVLELLL 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 805827552 110 EFMYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18258   77 EFVYTGSLIIDSANAKTLLEAANKFQFHTFCKV 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  21 EKFSELLA-----RQA--LVDVTLVCEGQKLRVHKLVLASNSTYFehlKKpclmdiLFTTCEEHLFSVKEILQKDLSQep 93
Cdd:cd18327    7 EHSSELLSclneqRRAglLCDLTIKTRGLEYRTHRAVLAACSLYF---RK------LFTGGGGGSGDLGAGGGQDVCE-- 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 805827552  94 iiflkdLNF---EILKAMVEFMYCGETTVPYQLLSSLLTATktfKVKELTSVVDAMM 147
Cdd:cd18327   76 ------LDFvgpEALGALLEFAYTATLTISSSNMREVLRAA---RLLEIPCVADACA 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  32 LVDVTLVCEGQKLRVHKLVLASNSTYFehlKKpclmdiLFTtcEEHLFSVKEILQKDLSQEpiiflkdlnfEILKAMVEF 111
Cdd:cd18198   25 LCDVVILVQGREYRTHRSVLAACSQYF---KK------LFT--SGAVVDQQNVYEIDFVSP----------EALTALLEF 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 805827552 112 MYCGETTVPYQLLSSLLTATKTFKVKELTSV 142
Cdd:cd18198   84 AYTATLTVSTANVGDILSAARLLEIPCVSHV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30
                 ....*....|....*....|....*....|
gi 805827552  29 RQALVDVTLVCEGQKLRVHKLVLASNSTYF 58
Cdd:cd18277   24 KDVLCDVTILVEGQRFRAHRSVLAACSSYF 53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  19 ITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNS----TYFEHlkkpclmdilftTCEEHLFSVKEIlqkdlsqepi 94
Cdd:cd18344   10 LTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSpvfrAMFEH------------EMEERLKNPIEI---------- 67

                         90       100
                 ....*....|....*....|..
gi 805827552  95 iflKDLNFEILKAMVEFMYCGE 116
Cdd:cd18344   68 ---HDLDPQVFKEMMGFIYTGK 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEHLkkpclmdilftTCEehlfsvkeiLQKDLSQEPI 94
Cdd:cd18230    4 HYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTL-----------YCQ---------VQKTSDQATV 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 805827552  95 IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFkvkELTSVVDA 145
Cdd:cd18230   64 THLDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAASYL---QMTDIVQA 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITEKFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFttceehlfsvkeilqkdLSQEPI 94
Cdd:cd18206    5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFR---------MLF-----------------VDQKDV 58

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 805827552  95 IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFKVKELTSVVDAM 146
Cdd:cd18206   59 VHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805827552  15 HARFITekFSELLARQALVDVTLVCEGQKLRVHKLVLASNSTYFEhlkkpclmdILFTTceehlfsvkEILQkdlSQEPI 94
Cdd:cd18246   24 HDAFVS--MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFH---------AMFTN---------EMSE---SRQTH 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 805827552  95 IFLKDLNFEILKAMVEFMYCGETTVPYQLLSSLLTATKTFkvkELTSVVDA 145
Cdd:cd18246   81 VTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASLL---QLNGVRDA 128