NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|998705685|ref|XP_015490569|]
View 

ankyrin repeat and zinc finger domain-containing protein 1 isoform X1 [Parus major]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 195-339 3.00e-74

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


:

Pssm-ID: 465880  Cd Length: 143  Bit Score: 236.25  E-value: 3.00e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685  195 WVVLMMGGGHFAGAVFRGLQVQEHKTFHRYTVRARRGTAQGLRDAQTpgSAPRSAGASLRRYNEAALLKDIQDLLAAWAQ 274
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAK--GKAKSAGASLRRYNEQALQEDIRELLSEWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 998705685  275 HLNEAQRIFLRAPRQNRALLFGGRNPLLTRGDPRICHIPLSTRRATLREVLRVHTTLASLQVYGK 339
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 670-710 4.73e-20

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


:

Pssm-ID: 465846  Cd Length: 43  Bit Score: 83.52  E-value: 4.73e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 998705685  670 ANISRCWHCGESLLGRIPFHYLDFSFCSTACLQTHRRAQAG 710
Cdd:pfam18716   1 KNYRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFA 41
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
476-563 4.86e-09

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 4.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685 476 DALFTACKTGDIRTLRHLLgvpeDGGLPGDSEDGE------------SLDMARSLLNQ-----PVDERGCTLLHVAARAG 538
Cdd:COG0666   89 TLLHAAARNGDLEIVKLLL----EAGADVNARDKDgetplhlaayngNLEIVKLLLEAgadvnAQDNDGNTPLHLAAANG 164

                         90       100
                 ....*....|....*....|....*
gi 998705685 539 KAEAVCLLLEAGADPALRDRQERTP 563
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETP 189
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 195-339 3.00e-74

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 236.25  E-value: 3.00e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685  195 WVVLMMGGGHFAGAVFRGLQVQEHKTFHRYTVRARRGTAQGLRDAQTpgSAPRSAGASLRRYNEAALLKDIQDLLAAWAQ 274
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAK--GKAKSAGASLRRYNEQALQEDIRELLSEWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 998705685  275 HLNEAQRIFLRAPRQNRALLFGGRNPLLTRGDPRICHIPLSTRRATLREVLRVHTTLASLQVYGK 339
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 670-710 4.73e-20

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


Pssm-ID: 465846  Cd Length: 43  Bit Score: 83.52  E-value: 4.73e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 998705685  670 ANISRCWHCGESLLGRIPFHYLDFSFCSTACLQTHRRAQAG 710
Cdd:pfam18716   1 KNYRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFA 41
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
476-563 4.86e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 4.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685 476 DALFTACKTGDIRTLRHLLgvpeDGGLPGDSEDGE------------SLDMARSLLNQ-----PVDERGCTLLHVAARAG 538
Cdd:COG0666   89 TLLHAAARNGDLEIVKLLL----EAGADVNARDKDgetplhlaayngNLEIVKLLLEAgadvnAQDNDGNTPLHLAAANG 164

                         90       100
                 ....*....|....*....|....*
gi 998705685 539 KAEAVCLLLEAGADPALRDRQERTP 563
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETP 189
Ank_2 pfam12796
Ankyrin repeats (3 copies);
478-557 1.57e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685  478 LFTACKTGDIRTLRHLLGVPEDGGLPGDSED--------GESLDMARSLLNQP---VDERGCTLLHVAARAGKAEAVCLL 546
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRtalhlaakNGHLEIVKLLLEHAdvnLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 998705685  547 LEAGADPALRD 557
Cdd:pfam12796  81 LEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 523-599 7.44e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 7.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998705685 523 VDERGCTLLHVAARAGKAEAVCLLLEAGADPALRDRQERTPYCVSADRVTRNAFRKFMVVHPDKYDYSRAKVPGPLT 599
Cdd:PTZ00322 111 RDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKPDSFT 187
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 526-553 1.62e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.62e-03
                           10        20
                   ....*....|....*....|....*...
gi 998705685   526 RGCTLLHVAARAGKAEAVCLLLEAGADP 553
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 195-339 3.00e-74

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 236.25  E-value: 3.00e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685  195 WVVLMMGGGHFAGAVFRGLQVQEHKTFHRYTVRARRGTAQGLRDAQTpgSAPRSAGASLRRYNEAALLKDIQDLLAAWAQ 274
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAK--GKAKSAGASLRRYNEQALQEDIRELLSEWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 998705685  275 HLNEAQRIFLRAPRQNRALLFGGRNPLLTRGDPRICHIPLSTRRATLREVLRVHTTLASLQVYGK 339
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
VATC pfam18716
Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but ...
 670-710 4.73e-20

Vms1-associating treble clef domain; Treble clef fold domain found at C-terminus of many, but not all, Vms1/ANKZF1-like proteins.


Pssm-ID: 465846  Cd Length: 43  Bit Score: 83.52  E-value: 4.73e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 998705685  670 ANISRCWHCGESLLGRIPFHYLDFSFCSTACLQTHRRAQAG 710
Cdd:pfam18716   1 KNYRRCWICGESLLGKVPFHKLDFSYCSTKCLRAHRRAGFA 41
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
476-563 4.86e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 4.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685 476 DALFTACKTGDIRTLRHLLgvpeDGGLPGDSEDGE------------SLDMARSLLNQ-----PVDERGCTLLHVAARAG 538
Cdd:COG0666   89 TLLHAAARNGDLEIVKLLL----EAGADVNARDKDgetplhlaayngNLEIVKLLLEAgadvnAQDNDGNTPLHLAAANG 164

                         90       100
                 ....*....|....*....|....*
gi 998705685 539 KAEAVCLLLEAGADPALRDRQERTP 563
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
477-563 6.80e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.66  E-value: 6.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685 477 ALFTACKTGDIRTLRHLL--GVP-----EDGGLP-------GDsedgesLDMARSLLNQPVD-----ERGCTLLHVAARA 537
Cdd:COG0666  123 PLHLAAYNGNLEIVKLLLeaGADvnaqdNDGNTPlhlaaanGN------LEIVKLLLEAGADvnardNDGETPLHLAAEN 196

                         90       100
                 ....*....|....*....|....*.
gi 998705685 538 GKAEAVCLLLEAGADPALRDRQERTP 563
Cdd:COG0666  197 GHLEIVKLLLEAGADVNAKDNDGKTA 222
Ank_2 pfam12796
Ankyrin repeats (3 copies);
478-557 1.57e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.43  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 998705685  478 LFTACKTGDIRTLRHLLGVPEDGGLPGDSED--------GESLDMARSLLNQP---VDERGCTLLHVAARAGKAEAVCLL 546
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRtalhlaakNGHLEIVKLLLEHAdvnLKDNGRTALHYAARSGHLEIVKLL 80

                          90
                  ....*....|.
gi 998705685  547 LEAGADPALRD 557
Cdd:pfam12796  81 LEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
524-564 1.42e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 1.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 998705685  524 DERGCTLLHVAARAGKAEAVCLLLEAGADPALRDRQERTPY 564
Cdd:pfam13857  13 DGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
515-570 1.49e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 47.64  E-value: 1.49e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 998705685 515 ARSLLNQPVDERGCTLLHVAARAGKAEAVCLLLEAGADPALRDRQERTPYCVSADR 570
Cdd:COG0666   75 AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 526-558 2.57e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.51  E-value: 2.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 998705685  526 RGCTLLHVAA-RAGKAEAVCLLLEAGADPALRDR 558
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 523-599 7.44e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 7.44e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 998705685 523 VDERGCTLLHVAARAGKAEAVCLLLEAGADPALRDRQERTPYCVSADRVTRNAFRKFMVVHPDKYDYSRAKVPGPLT 599
Cdd:PTZ00322 111 RDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGANAKPDSFT 187
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 670-701 5.20e-04

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 38.12  E-value: 5.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 998705685  670 ANISRCWHCGESLLGRIPFHYLDFS-----FCSTACL 701
Cdd:pfam06467   1 LVKATCWFCKKLIKNKPTVIVLQNDgsvgqFCSQSCL 37
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 526-553 8.99e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.24  E-value: 8.99e-04
                          10        20
                  ....*....|....*....|....*...
gi 998705685  526 RGCTLLHVAARAGKAEAVCLLLEAGADP 553
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 526-553 1.62e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 1.62e-03
                           10        20
                   ....*....|....*....|....*...
gi 998705685   526 RGCTLLHVAARAGKAEAVCLLLEAGADP 553
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
Ank_2 pfam12796
Ankyrin repeats (3 copies);
531-563 1.76e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 1.76e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 998705685  531 LHVAARAGKAEAVCLLLEAGADPALRDRQERTP 563
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTA 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH