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Conserved domains on  [gi|1034556031|ref|XP_016855973|]
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KN motif and ankyrin repeat domain-containing protein 4 isoform X4 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
185-360 5.60e-35

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.69  E-value: 5.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 185 LKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMitpLASAETNEDMAvvwKLLRE--GNVNI 262
Cdd:COG0666    76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLH---LAAYNGNLEIV---KLLLEagADVNA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 263 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 342
Cdd:COG0666   149 Q-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLA 226

                         170
                  ....*....|....*...
gi 1034556031 343 LKSPtHMEIAGLLRAHAE 360
Cdd:COG0666   227 AENG-NLEIVKLLLEAGA 243
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
185-360 5.60e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.69  E-value: 5.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 185 LKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMitpLASAETNEDMAvvwKLLRE--GNVNI 262
Cdd:COG0666    76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLH---LAAYNGNLEIV---KLLLEagADVNA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 263 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 342
Cdd:COG0666   149 Q-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLA 226

                         170
                  ....*....|....*...
gi 1034556031 343 LKSPtHMEIAGLLRAHAE 360
Cdd:COG0666   227 AENG-NLEIVKLLLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
272-358 2.38e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 2.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 272 LMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSsltDKAGRTALSIALKSpTHMEI 351
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARS-GHLEI 76


                  ....*..
gi 1034556031 352 AGLLRAH 358
Cdd:pfam12796  77 VKLLLEK 83
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 189-359 1.08e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 189 VNLADHNGNTALHYSVSHSNFSIVKLLLETGV-CNVDHQNKAgytavmiTPLASAETNEDMAVVWKLLREGNVNIQATQG 267
Cdd:PHA02874  150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyANVKDNNGE-------SPLHNAAEYGDYACIKLLIDHGNHIMNKCKN 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 268 GQTALMLGVSHDREdmVQALLSCQADVNLQDHDGSSALmvacHHG-----NVDLVRLLLAHPAcDSSLTDKAGRTALSIA 342
Cdd:PHA02874  223 GFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPL----HHAinppcDIDIIDILLYHKA-DISIKDNKGENPIDTA 295

                         170
                  ....*....|....*..
gi 1034556031 343 LKSPTHMEIAGLLRAHA 359
Cdd:PHA02874  296 FKYINKDPVIKDIIANA 312
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 195-220 1.68e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.68e-03
                           10        20
                   ....*....|....*....|....*.
gi 1034556031  195 NGNTALHYSVSHSNFSIVKLLLETGV 220
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
185-360 5.60e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 129.69  E-value: 5.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 185 LKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMitpLASAETNEDMAvvwKLLRE--GNVNI 262
Cdd:COG0666    76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGETPLH---LAAYNGNLEIV---KLLLEagADVNA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 263 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 342
Cdd:COG0666   149 Q-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLA 226

                         170
                  ....*....|....*...
gi 1034556031 343 LKSPtHMEIAGLLRAHAE 360
Cdd:COG0666   227 AENG-NLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
189-360 3.48e-29

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 114.28  E-value: 3.48e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 189 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTavmitPLASAETNEDMAVVWKLLREG-NVNIQaTQG 267
Cdd:COG0666   113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNT-----PLHLAAANGNLEIVKLLLEAGaDVNAR-DND 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 268 GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPT 347
Cdd:COG0666   186 GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGA 264

                         170
                  ....*....|...
gi 1034556031 348 HMEIAGLLRAHAE 360
Cdd:COG0666   265 ALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
184-358 5.74e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.12  E-value: 5.74e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 184 FLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTavmitPLASAETNEDMAVVWKLLREG-NVNI 262
Cdd:COG0666    41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNT-----LLHAAARNGDLEIVKLLLEAGaDVNA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 263 QaTQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIA 342
Cdd:COG0666   116 R-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLA 193

                         170
                  ....*....|....*.
gi 1034556031 343 LKSPtHMEIAGLLRAH 358
Cdd:COG0666   194 AENG-HLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
184-358 8.57e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.17  E-value: 8.57e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 184 FLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQ 263
Cdd:COG0666     3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 264 ATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIAL 343
Cdd:COG0666    83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAA 161

                         170
                  ....*....|....*
gi 1034556031 344 KSPtHMEIAGLLRAH 358
Cdd:COG0666   162 ANG-NLEIVKLLLEA 175
Ank_2 pfam12796
Ankyrin repeats (3 copies);
272-358 2.38e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 70.92  E-value: 2.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 272 LMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSsltDKAGRTALSIALKSpTHMEI 351
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL---KDNGRTALHYAARS-GHLEI 76


                  ....*..
gi 1034556031 352 AGLLRAH 358
Cdd:pfam12796  77 VKLLLEK 83
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-298 3.48e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 3.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 200 LHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAVMItplasAETNEDMAVVWKLLREGNVNIQAtqGGQTALMLGVSHD 279
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHL-----AAKNGHLEIVKLLLEHADVNLKD--NGRTALHYAARSG 72

                          90
                  ....*....|....*....
gi 1034556031 280 REDMVQALLSCQADVNLQD 298
Cdd:pfam12796  73 HLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 189-359 1.08e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.92  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 189 VNLADHNGNTALHYSVSHSNFSIVKLLLETGV-CNVDHQNKAgytavmiTPLASAETNEDMAVVWKLLREGNVNIQATQG 267
Cdd:PHA02874  150 VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAyANVKDNNGE-------SPLHNAAEYGDYACIKLLIDHGNHIMNKCKN 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 268 GQTALMLGVSHDREdmVQALLSCQADVNLQDHDGSSALmvacHHG-----NVDLVRLLLAHPAcDSSLTDKAGRTALSIA 342
Cdd:PHA02874  223 GFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPL----HHAinppcDIDIIDILLYHKA-DISIKDNKGENPIDTA 295

                         170
                  ....*....|....*..
gi 1034556031 343 LKSPTHMEIAGLLRAHA 359
Cdd:PHA02874  296 FKYINKDPVIKDIIANA 312
Ank_2 pfam12796
Ankyrin repeats (3 copies);
245-325 1.28e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 245 NEDMAVVWKLLREG-NVNIQaTQGGQTALMLGVSHDREDMVQALLScQADVNLQDHdGSSALMVACHHGNVDLVRLLLAH 323
Cdd:pfam12796   7 NGNLELVKLLLENGaDANLQ-DKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83


                  ..
gi 1034556031 324 PA 325
Cdd:pfam12796  84 GA 85
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 189-326 8.40e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.89  E-value: 8.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 189 VNLADHNGNTALHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAVMItplaSAETNEDMAVVWKLLREG-NVNIQATQG 267
Cdd:PHA02878  194 VNIPDKTNNSPLHHAVKHYNKPIVHILLENG-ASTDARDKCGNTPLHI----SVGYCKDYDILKLLLEHGvDVNAKSYIL 268

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 268 GQTALMLGVsHDrEDMVQALLSCQADVNLQDHDGSSAL-MVACHHGNVDLVRLLLAHPAC 326
Cdd:PHA02878  269 GLTALHSSI-KS-ERKLKLLLEYGADINSLNSYKLTPLsSAVKQYLCINIGRILISNICL 326
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 144-323 3.92e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 57.75  E-value: 3.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 144 LLRQSLNTisqewfRVSSRKSSSPAVVASYLHEVQPHSPHFLKLL------VNLADHNGNTALHYSVSHS--NFSIVKLL 215
Cdd:PHA03100   54 LLDNGADI------NSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLleyganVNAPDNNGITPLLYAISKKsnSYSIVEYL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 216 LETGvCNVDHQNKAGYTAVMITpLASAETNEDMAvvwKLLREGNVNIQA--------TQG---------GQTALMLGVSH 278
Cdd:PHA03100  128 LDNG-ANVNIKNSDGENLLHLY-LESNKIDLKIL---KLLIDKGVDINAknrvnyllSYGvpinikdvyGFTPLHYAVYN 202

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1034556031 279 DREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAH 323
Cdd:PHA03100  203 NNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 284-366 7.03e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.22  E-value: 7.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 284 VQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSPTHmEIAGLLRAHAEQGR 363
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA-DPTLLDKDGKTPLELAEENGFR-EVVQLLSRHSQCHF 175


                  ...
gi 1034556031 364 SLG 366
Cdd:PTZ00322  176 ELG 178
Ank_5 pfam13857
Ankyrin repeats (many copies);
287-342 1.11e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.81  E-value: 1.11e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034556031 287 LLSC-QADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPaCDSSLTDKAGRTALSIA 342
Cdd:pfam13857   1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
270-321 2.17e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.27  E-value: 2.17e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034556031 270 TALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLL 321
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 186-325 7.82e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.02  E-value: 7.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 186 KLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAvMITPLASAEtNEDMAVVWKLLREGNvniqaT 265
Cdd:PLN03192  548 KLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA-CNVHIRDANGNTA-LWNAISAKH-HKIFRILYHFASISD-----P 619

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 266 QGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPA 325
Cdd:PLN03192  620 HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
PHA03095 PHA03095
ankyrin-like protein; Provisional
 245-355 9.57e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 9.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 245 NEDMAVVWKLLREG-NVNiQATQGGQTAL---MLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNV-DLVRL 319
Cdd:PHA03095   24 NVTVEEVRRLLAAGaDVN-FRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKL 102

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034556031 320 LLAHPAcDSSLTDKAGRTALSIALKSP-THMEIAGLL 355
Cdd:PHA03095  103 LIKAGA-DVNAKDKVGRTPLHVYLSGFnINPKVIRLL 138
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 184-264 3.68e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 3.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 184 FLKLLV--NLADHNGNTALHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYtavmiTPLASAETNEDMAVVwKLLREGNVN 261
Cdd:PHA03100  178 LLSYGVpiNIKDVYGFTPLHYAVYNNNPEFVKYLLDLG-ANPNLVNKYGD-----TPLHIAILNNNKEIF-KLLLNNGPS 250


                  ...
gi 1034556031 262 IQA 264
Cdd:PHA03100  251 IKT 253
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 200-359 3.78e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 3.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 200 LHYSVSHSNFSIVKLLLETGvCNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREG--------------------- 258
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNG-ADINSSTKNNSTPLHYLSNIKYNLTDVKEIVKLLLEYGanvnapdnngitpllyaiskk 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 259 ---------------NVNIQaTQGGQTALML------------------GVSHDREDMVQALLSCQADVNLQDHDGSSAL 305
Cdd:PHA03100  118 snsysiveylldngaNVNIK-NSDGENLLHLylesnkidlkilkllidkGVDINAKNRVNYLLSYGVPINIKDVYGFTPL 196

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034556031 306 MVACHHGNVDLVRLLLaHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHA 359
Cdd:PHA03100  197 HYAVYNNNPEFVKYLL-DLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 190-343 3.80e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 48.45  E-value: 3.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 190 NLADHNGNTALHYSVSHSNFSIVKLLLETG-VCNVDHQNkagytavMITPLASAETNEDMAVVWKLLREGN-VNIQATQG 267
Cdd:PHA02875   29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGaIPDVKYPD-------IESELHDAVEEGDVKAVEELLDLGKfADDVFYKD 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034556031 268 GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACdSSLTDKAGRTALSIAL 343
Cdd:PHA02875  102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAM 176
PHA03095 PHA03095
ankyrin-like protein; Provisional
 189-346 1.79e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 46.56  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 189 VNLADHNGNTALHYSVSHSN-FSIVKLLLETGVcNVDHQNKAGYTAVMITpLASAETNEDmaVVWKLLREGnvniqatqg 267
Cdd:PHA03095   76 VNAPERCGFTPLHLYLYNATtLDVIKLLIKAGA-DVNAKDKVGRTPLHVY-LSGFNINPK--VIRLLLRKG--------- 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 268 gqtalmlgvshdredmvqallscqADVNLQDHDGSSAL--MVACHHGNVDLVRLLLAHpACDSSLTDKAGRTALSIALKS 345
Cdd:PHA03095  143 ------------------------ADVNALDLYGMTPLavLLKSRNANVELLRLLIDA-GADVYAVDDRFRSLLHHHLQS 197


                  .
gi 1034556031 346 P 346
Cdd:PHA03095  198 F 198
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 162-296 5.08e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 5.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 162 RKSSSPAVVASYLHEVQphsphFLKLLV------NLADHNGNTALHYSVSHSNFSIVKLLLETGVCnVDHQNKAGYTavm 235
Cdd:PHA02875  100 KDGMTPLHLATILKKLD-----IMKLLIargadpDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCT--- 170

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034556031 236 itPLASAETNEDMAVVWKLLREG-NVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNL 296
Cdd:PHA02875  171 --PLIIAMAKGDIAICKMLLDSGaNIDYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNI 230
Ank_4 pfam13637
Ankyrin repeats (many copies);
301-355 7.48e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 7.48e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034556031 301 GSSALMVACHHGNVDLVRLLLAHPAcDSSLTDKAGRTALSIALKSpTHMEIAGLL 355
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHFAASN-GNVEVLKLL 53
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 189-358 7.72e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.49  E-value: 7.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 189 VNLADHNGNTALHYSVSHSN-FSIVKLLLETGVCNVDHQNKAGYTA-----------VMITPLASAETNEDM-------- 248
Cdd:PHA02878   63 VNQPDHRDLTPLHIICKEPNkLGMKEMIRSINKCSVFYTLVAIKDAfnnrnveifkiILTNRYKNIQTIDLVyidkkskd 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 249 ----AVVWKLLRE--GNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLA 322
Cdd:PHA02878  143 diieAEITKLLLSygADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLE 222

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1034556031 323 HPAcDSSLTDKAGRTALSIALKSPTHMEIAGLLRAH 358
Cdd:PHA02878  223 NGA-STDARDKCGNTPLHISVGYCKDYDILKLLLEH 257
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 189-343 1.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.51  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 189 VNLADHNGNTALHYSVSHSNFS-IVKLLLETGVcNVDHQNKAGYTAVMITplasAETNEDMAVVWKLLREGnVNIQATQG 267
Cdd:PHA02876  266 VNSIDDCKNTPLHHASQAPSLSrLVPKLLERGA-DVNAKNIKGETPLYLM----AKNGYDTENIRTLIMLG-ADVNAADR 339

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034556031 268 -GQTALMLGVSHDR-EDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGrTALSIAL 343
Cdd:PHA02876  340 lYITPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIG-TALHFAL 416
Ank_5 pfam13857
Ankyrin repeats (many copies);
254-308 1.61e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 39.25  E-value: 1.61e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034556031 254 LLREGNVNIQATQG-GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVA 308
Cdd:pfam13857   1 LLEHGPIDLNRLDGeGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 185-322 2.56e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.70  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 185 LKLLVNL------ADHNGNTALHY--SVSHSNFSIVKLLLETGvCNVDHQNKAGYTavmitPLASAETNEDMA--VVWKL 254
Cdd:PHA03095  170 LRLLIDAgadvyaVDDRFRSLLHHhlQSFKPRARIVRELIRAG-CDPAATDMLGNT-----PLHSMATGSSCKrsLVLPL 243

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034556031 255 LrEGNVNIQAT-QGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLA 322
Cdd:PHA03095  244 L-IAGISINARnRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 268-330 3.12e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 3.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034556031 268 GQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSL 330
Cdd:PTZ00322  115 GRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
Ank_4 pfam13637
Ankyrin repeats (many copies);
189-216 3.21e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 3.21e-04
                          10        20
                  ....*....|....*....|....*...
gi 1034556031 189 VNLADHNGNTALHYSVSHSNFSIVKLLL 216
Cdd:pfam13637  27 INAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 195-228 3.66e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 3.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034556031 195 NGNTALHYSVSHS-NFSIVKLLLETGvCNVDHQNK 228
Cdd:pfam00023   1 DGNTPLHLAAGRRgNLEIVKLLLSKG-ADVNARDK 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
196-249 3.72e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.02  E-value: 3.72e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034556031 196 GNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMItplASAETNEDMA 249
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGA-DINAVDGNGETALHF---AASNGNVEVL 50
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 300-325 1.20e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034556031 300 DGSSALMVACHHGNVDLVRLLLAHPA 325
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGA 26
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 195-220 1.68e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.68e-03
                           10        20
                   ....*....|....*....|....*.
gi 1034556031  195 NGNTALHYSVSHSNFSIVKLLLETGV 220
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 300-323 2.51e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 2.51e-03
                           10        20
                   ....*....|....*....|....
gi 1034556031  300 DGSSALMVACHHGNVDLVRLLLAH 323
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDK 24
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 268-295 2.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 2.52e-03
                          10        20
                  ....*....|....*....|....*...
gi 1034556031 268 GQTALMLGVSHDREDMVQALLSCQADVN 295
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 211-344 2.75e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.56  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034556031 211 IVKLLLETGVcnvdhqnkagYTAVMITPlasaETNEDMavVWKLLREG-NVNIQATQGgQTALMLGVSHDREDMVQALLS 289
Cdd:PHA02874   83 IIKLLIDNGV----------DTSILPIP----CIEKDM--IKTILDCGiDVNIKDAEL-KTFLHYAIKKGDLESIKMLFE 145

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034556031 290 CQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACdSSLTDKAGRTALSIALK 344
Cdd:PHA02874  146 YGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAE 199
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 195-220 3.38e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.54  E-value: 3.38e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034556031 195 NGNTALHYSVSHSNFSIVKLLLETGV 220
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGA 26
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 268-299 4.68e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 4.68e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034556031 268 GQTALMLGVSH-DREDMVQALLSCQADVNLQDH 299
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_5 pfam13857
Ankyrin repeats (many copies);
187-234 4.71e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 4.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034556031 187 LLVNLADHNGNTALHYSVSHSNFSIVKLLLETGV-CNVdhQNKAGYTAV 234
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVdLNL--KDEEGLTAL 53
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
189-265 6.91e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 38.01  E-value: 6.91e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034556031 189 VNLADHNGNTALHYSVSHSNFSIVKLLLETGVcNVDHQNKAGYTAVMITPLASAETNEDMAVVWKLLREGNVNIQAT 265
Cdd:COG0666   212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGA-DLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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