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Conserved domains on  [gi|1034558245|ref|XP_016856677|]
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regulator of G-protein signaling protein-like isoform X1 [Homo sapiens]

Protein Classification

regulator of G-protein signaling domain-containing protein( domain architecture ID 10171662)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 685-864 1.02e-89

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


:

Pssm-ID: 188683  Cd Length: 179  Bit Score: 285.58  E-value: 1.02e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  685 LLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVT 764
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  765 TSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLqESQKKGWMRMISFIRSFCKYRRFM 844
Cdd:cd08728     81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVI-SSQKRAWEIFISFIRSFIKFRRFM 159

                          170       180
                   ....*....|....*....|
gi 1034558245  845 LNPSKRQEFEDYLHQEMQNS 864
Cdd:cd08728    160 VNREIRQEFEDYLVQEMENY 179
RGS super family cl02565
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 911-1015 8.65e-08

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


The actual alignment was detected with superfamily member cd08725:

Pssm-ID: 470619  Cd Length: 123  Bit Score: 52.01  E-value: 8.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  911 NFAINDLYFFSEMEKFNDLVSSahmlqvnraynENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAaiTEGY 990
Cdd:cd08725     19 EELENDLLFWLEVQKYKDLCHS-----------HSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRILE--HRRE 85

                           90       100
                   ....*....|....*....|....*
gi 1034558245  991 LDRSVFHGAIMSVFPVVMYFWKRFC 1015
Cdd:cd08725     86 LGPYIFREAQLTVFRVLFKYWAGFC 110
 
Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 685-864 1.02e-89

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 285.58  E-value: 1.02e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  685 LLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVT 764
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  765 TSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLqESQKKGWMRMISFIRSFCKYRRFM 844
Cdd:cd08728     81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVI-SSQKRAWEIFISFIRSFIKFRRFM 159

                          170       180
                   ....*....|....*....|
gi 1034558245  845 LNPSKRQEFEDYLHQEMQNS 864
Cdd:cd08728    160 VNREIRQEFEDYLVQEMENY 179
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 911-1015 8.65e-08

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 52.01  E-value: 8.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  911 NFAINDLYFFSEMEKFNDLVSSahmlqvnraynENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAaiTEGY 990
Cdd:cd08725     19 EELENDLLFWLEVQKYKDLCHS-----------HSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRILE--HRRE 85

                           90       100
                   ....*....|....*....|....*
gi 1034558245  991 LDRSVFHGAIMSVFPVVMYFWKRFC 1015
Cdd:cd08725     86 LGPYIFREAQLTVFRVLFKYWAGFC 110
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 680-789 8.29e-03

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 37.21  E-value: 8.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  680 NLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKI-SIETNEKIcKSLIENVIKTFFQGQLSPEemLQCDAPIIKEIA 758
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFkKADPDEER-LKKAKEIYNEFLAPGSPKE--INLDSDLREEIR 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034558245  759 S-MRHVTTSTLL-TLQGHVMKSIEEKWFKDYQD 789
Cdd:pfam00615   78 EnLEKEPTRDLFdEAQAEVYELMEKDSYPRFLK 110
 
Name Accession Description Interval E-value
RGS-like_2 cd08728
Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These ...
 685-864 1.02e-89

Uncharacterized Regulator of G protein Signaling (RGS) domain subfamily, child 2; These uncharacterized RGS-like domains consists largely of hypothetical proteins. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play an important role in neuronal signal modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188683  Cd Length: 179  Bit Score: 285.58  E-value: 1.02e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  685 LLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVT 764
Cdd:cd08728      1 LRNHTHLEYFKRFLKSRGSDGPLLFWIAVEKMRVEENEKEQKAKIELIVKRYFHGQDPPGVLLQCEAIIIREIAMMKVVT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  765 TSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLqESQKKGWMRMISFIRSFCKYRRFM 844
Cdd:cd08728     81 TSMLLSIQHLVSKSLEERWFKKYQDTFPDCPHEVEPDEEIKVPLKPTKLKAPHVI-SSQKRAWEIFISFIRSFIKFRRFM 159

                          170       180
                   ....*....|....*....|
gi 1034558245  845 LNPSKRQEFEDYLHQEMQNS 864
Cdd:cd08728    160 VNREIRQEFEDYLVQEMENY 179
RGS_RGS22_4 cd08725
Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) ...
 911-1015 8.65e-08

Regulator of G protein signaling domain RGS_RGS22_4; The RGS (Regulator of G-protein Signaling) domain found in the RGS22 protein, a member of the RA/RGS subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. RGS22 contains at least 3 copies of the RGS domain in vertebrata and exists in multiple splicing variants. RGS22 is predominantly expressed in testis and believed to play an important role in spermatogenesis.


Pssm-ID: 188680  Cd Length: 123  Bit Score: 52.01  E-value: 8.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  911 NFAINDLYFFSEMEKFNDLVSSahmlqvnraynENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAaiTEGY 990
Cdd:cd08725     19 EELENDLLFWLEVQKYKDLCHS-----------HSDEHIIQNKITAIISCFIDSSVPPALQIDIPPEIANRILE--HRRE 85

                           90       100
                   ....*....|....*....|....*
gi 1034558245  991 LDRSVFHGAIMSVFPVVMYFWKRFC 1015
Cdd:cd08725     86 LGPYIFREAQLTVFRVLFKYWAGFC 110
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 680-789 8.29e-03

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 37.21  E-value: 8.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034558245  680 NLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKI-SIETNEKIcKSLIENVIKTFFQGQLSPEemLQCDAPIIKEIA 758
Cdd:pfam00615    1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFkKADPDEER-LKKAKEIYNEFLAPGSPKE--INLDSDLREEIR 77

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034558245  759 S-MRHVTTSTLL-TLQGHVMKSIEEKWFKDYQD 789
Cdd:pfam00615   78 EnLEKEPTRDLFdEAQAEVYELMEKDSYPRFLK 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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