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Conserved domains on  [gi|1034561023|ref|XP_016857560|]
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E3 ubiquitin-protein ligase COP1 isoform X21 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00181 super family cl31831
protein SPA1-RELATED; Provisional
 22-485 3.72e-106

protein SPA1-RELATED; Provisional


The actual alignment was detected with superfamily member PLN00181:

Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 335.52  E-value: 3.72e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023  22 QILMEFLKVARRNKREQLEQIQKELSVLEEDI------------------------KRVEE-MSGLYSPVSEDSTVPQFE 76
Cdd:PLN00181  292 ELLLEFLFLIQQRKQEAADKLQDTISLLSSDIdqvvkrqlvlqqkgsdvrsflasrKRIRQgAETLAAEEENDDNSSKLD 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023  77 APSPSHSLEFSsdmhRIFVNGILIISIIDSTEYSQPpgfsgssqtkkqpwynSTLASRRKRLTAHFEDLEQCYFSTRMSR 156
Cdd:PLN00181  372 DTLESTLLESS----RLMRNLKKLESVYFATRYRQI----------------KAAAAAEKPLARYYSALSENGRSSEKSS 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 157 IS----------DDSRTASQLDEFQECLSKFTRYNSVRPLATLSyASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVY 226
Cdd:PLN00181  432 MSnpakppdfyiNDSRQGGWIDPFLEGLCKYLSFSKLRVKADLK-QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIF 510

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 227 EYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKL 306
Cdd:PLN00181  511 ECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTL 590

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 307 LASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFV 386
Cdd:PLN00181  591 LASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV 670

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 387 SGEEIVSASTDSQLKLWNVGKPYC------LRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDT 460
Cdd:PLN00181  671 DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKT 750

                         490       500
                  ....*....|....*....|....*
gi 1034561023 461 VKSVldKDRKEDDTNEFVSAVCWRA 485
Cdd:PLN00181  751 IDPV--SGLEVDDASQFISSVCWRG 773
 
Name Accession Description Interval E-value
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 22-485 3.72e-106

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 335.52  E-value: 3.72e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023  22 QILMEFLKVARRNKREQLEQIQKELSVLEEDI------------------------KRVEE-MSGLYSPVSEDSTVPQFE 76
Cdd:PLN00181  292 ELLLEFLFLIQQRKQEAADKLQDTISLLSSDIdqvvkrqlvlqqkgsdvrsflasrKRIRQgAETLAAEEENDDNSSKLD 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023  77 APSPSHSLEFSsdmhRIFVNGILIISIIDSTEYSQPpgfsgssqtkkqpwynSTLASRRKRLTAHFEDLEQCYFSTRMSR 156
Cdd:PLN00181  372 DTLESTLLESS----RLMRNLKKLESVYFATRYRQI----------------KAAAAAEKPLARYYSALSENGRSSEKSS 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 157 IS----------DDSRTASQLDEFQECLSKFTRYNSVRPLATLSyASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVY 226
Cdd:PLN00181  432 MSnpakppdfyiNDSRQGGWIDPFLEGLCKYLSFSKLRVKADLK-QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIF 510

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 227 EYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKL 306
Cdd:PLN00181  511 ECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTL 590

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 307 LASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFV 386
Cdd:PLN00181  591 LASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV 670

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 387 SGEEIVSASTDSQLKLWNVGKPYC------LRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDT 460
Cdd:PLN00181  671 DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKT 750

                         490       500
                  ....*....|....*....|....*
gi 1034561023 461 VKSVldKDRKEDDTNEFVSAVCWRA 485
Cdd:PLN00181  751 IDPV--SGLEVDDASQFISSVCWRG 773
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 199-445 2.88e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 2.88e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 199 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVD-IHYpenemtcnSKISCISWSSYHKNLLASSdYEGTVILWD 277
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHT--------GPVRDVAASADGTYLASGS-SDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 278 GFTGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADH 356
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTF-VASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 357 CVHYYDLRNTKqPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIAC 435
Cdd:cd00200   158 TIKLWDLRTGK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         250
                  ....*....|
gi 1034561023 436 GSENNSLYLY 445
Cdd:cd00200   237 GSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
186-464 7.15e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 7.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 186 LATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT--VIQdAVDIHypenemtcNSKISCISWSSyHKNL 263
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkLLR-TLTGH--------SGAVTSVAFSP-DGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 264 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFS 342
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsVRSVAFS 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 343 PSSRYhLAFGCADHCVHYYDLrNTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK 421
Cdd:COG2319   256 PDGRL-LASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1034561023 422 NFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFK--FDTVKSV 464
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTghTGAVTSV 378
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 280-320 1.28e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.28e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034561023  280 TGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 320
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
281-320 7.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034561023 281 GQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 320
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 22-485 3.72e-106

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 335.52  E-value: 3.72e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023  22 QILMEFLKVARRNKREQLEQIQKELSVLEEDI------------------------KRVEE-MSGLYSPVSEDSTVPQFE 76
Cdd:PLN00181  292 ELLLEFLFLIQQRKQEAADKLQDTISLLSSDIdqvvkrqlvlqqkgsdvrsflasrKRIRQgAETLAAEEENDDNSSKLD 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023  77 APSPSHSLEFSsdmhRIFVNGILIISIIDSTEYSQPpgfsgssqtkkqpwynSTLASRRKRLTAHFEDLEQCYFSTRMSR 156
Cdd:PLN00181  372 DTLESTLLESS----RLMRNLKKLESVYFATRYRQI----------------KAAAAAEKPLARYYSALSENGRSSEKSS 431

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 157 IS----------DDSRTASQLDEFQECLSKFTRYNSVRPLATLSyASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVY 226
Cdd:PLN00181  432 MSnpakppdfyiNDSRQGGWIDPFLEGLCKYLSFSKLRVKADLK-QGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIF 510

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 227 EYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKL 306
Cdd:PLN00181  511 ECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTL 590

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 307 LASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFV 386
Cdd:PLN00181  591 LASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV 670

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 387 SGEEIVSASTDSQLKLWNVGKPYC------LRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDT 460
Cdd:PLN00181  671 DSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKT 750

                         490       500
                  ....*....|....*....|....*
gi 1034561023 461 VKSVldKDRKEDDTNEFVSAVCWRA 485
Cdd:PLN00181  751 IDPV--SGLEVDDASQFISSVCWRG 773
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 199-445 2.88e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 2.88e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 199 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVD-IHYpenemtcnSKISCISWSSYHKNLLASSdYEGTVILWD 277
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHT--------GPVRDVAASADGTYLASGS-SDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 278 GFTGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADH 356
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTF-VASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 357 CVHYYDLRNTKqPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIAC 435
Cdd:cd00200   158 TIKLWDLRTGK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         250
                  ....*....|
gi 1034561023 436 GSENNSLYLY 445
Cdd:cd00200   237 GSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
186-464 7.15e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 7.15e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 186 LATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT--VIQdAVDIHypenemtcNSKISCISWSSyHKNL 263
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkLLR-TLTGH--------SGAVTSVAFSP-DGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 264 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFS 342
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsVRSVAFS 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 343 PSSRYhLAFGCADHCVHYYDLrNTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK 421
Cdd:COG2319   256 PDGRL-LASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1034561023 422 NFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFK--FDTVKSV 464
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTghTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
184-445 3.78e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 3.78e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 184 RPLATLSyasdlyNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT-VIQDAVDIHypenemtcNSKISCISWSSyHKN 262
Cdd:COG2319   153 KLLRTLT------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATgKLLRTLTGH--------TGAVRSVAFSP-DGK 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 263 LLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKF 341
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAF 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 342 SPSSRYhLAFGCADHCVHYYDLrNTKQPIMVFKGHRKAVSYAKFVS-GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINE 420
Cdd:COG2319   297 SPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                         250       260
                  ....*....|....*....|....*
gi 1034561023 421 KNFVGLASNGDYIACGSENNSLYLY 445
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-445 4.46e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.06  E-value: 4.46e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 186 LATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTViqdavdihYPENEMTC-NSKISCISWSSyHKNLL 264
Cdd:cd00200    38 LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--------ECVRTLTGhTSYVSSVAFSP-DGRIL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 265 ASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEA-KANVCCVKFSP 343
Cdd:cd00200   109 SSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSP 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 344 SSRyHLAFGCADHCVHYYDLRnTKQPIMVFKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKN 422
Cdd:cd00200   188 DGE-KLLSSSSDGTIKLWDLS-TGKCLGTLRGHENGVNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                         250       260
                  ....*....|....*....|...
gi 1034561023 423 FVGLASNGDYIACGSENNSLYLY 445
Cdd:cd00200   266 SLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
263-464 3.54e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 3.54e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 263 LLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKF 341
Cdd:COG2319    92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 342 SPSSRYhLAFGCADHCVHYYDLRnTKQPIMVFKGHRKAVSYAKFvS--GEEIVSASTDSQLKLWNVGKPYCLRSFKGHIN 419
Cdd:COG2319   171 SPDGKL-LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAF-SpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1034561023 420 EKNFVGLASNGDYIACGSENNSLYLY--YKGLSKTLLTFKFDTVKSV 464
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTGHSGGVNSV 294
WD40 COG2319
WD40 repeat [General function prediction only];
199-405 2.63e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 2.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 199 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT-VIQDAVDIHypenemtcNSKISCISWSSYHKnLLASSDYEGTVILWD 277
Cdd:COG2319   204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATgKLLRTLTGH--------SGSVRSVAFSPDGR-LLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 278 GFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADH 356
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKT-LASGSDDG 352

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561023 357 CVHYYDLrNTKQPIMVFKGHRKAVSYAKFVS-GEEIVSASTDSQLKLWNV 405
Cdd:COG2319   353 TVRLWDL-ATGELLRTLTGHTGAVTSVAFSPdGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 202-404 1.03e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 1.03e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 202 VSSIEFDRDCDYFAIAGVTKKIKVYeydtviqdavDIHYPENEMTCNSK---ISCISWSSYHKnLLASSDYEGTVILWDG 278
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVW----------DVETGKCLTTLRGHtdwVNSVAFSPDGT-FVASSSQDGTIKLWDL 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 279 FTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADHC 357
Cdd:cd00200   165 RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYL-LASGSEDGT 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034561023 358 VHYYDLRnTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWN 404
Cdd:cd00200   243 IRVWDLR-TGECVQTLSGHTNSVTSLAWSpDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
263-445 2.90e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 2.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 263 LLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEA-KANVCCVKF 341
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 342 SPSSRYhLAFGCADHCVHYYDLRnTKQPIMVFKGHRKAVSYAKFVS-GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINE 420
Cdd:COG2319   129 SPDGKT-LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 206

                         170       180
                  ....*....|....*....|....*
gi 1034561023 421 KNFVGLASNGDYIACGSENNSLYLY 445
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-445 1.16e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 284 SKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWSTNLDNSVASIE-AKANVCCVKFSPSSRYhLAFGCADHCVHYYD 362
Cdd:cd00200     2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 363 LrNTKQPIMVFKGHRKAVSYAKFVSGEEIV-SASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNS 441
Cdd:cd00200    80 L-ETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158


                  ....
gi 1034561023 442 LYLY 445
Cdd:cd00200   159 IKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
199-322 1.25e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 199 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTviQDAVDIHYPENEMtcnskISCISWSSYHKnLLASSDYEGTVILWDG 278
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHTGA-----VRSVAFSPDGK-TLASGSDDGTVRLWDL 359

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034561023 279 FTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTN 322
Cdd:COG2319   360 ATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
303-445 4.17e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 4.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561023 303 DPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSY 382
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034561023 383 AKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLY 445
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 280-320 1.28e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.28e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034561023  280 TGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 320
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
281-320 7.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034561023 281 GQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 320
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 366-404 1.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.05e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034561023  366 TKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWN 404
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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