NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034561041|ref|XP_016857569|]
View 

E3 ubiquitin-protein ligase COP1 isoform X27 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN00181 super family cl31831
protein SPA1-RELATED; Provisional
 52-405 1.12e-104

protein SPA1-RELATED; Provisional


The actual alignment was detected with superfamily member PLN00181:

Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 328.97  E-value: 1.12e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041  52 ASRRKRLTAHFEDLEQCYFSTRMSRIS----------DDSRTASQLDEFQECLSKFTRYNSVRPLATLSyASDLYNGSSI 121
Cdd:PLN00181  407 AAAEKPLARYYSALSENGRSSEKSSMSnpakppdfyiNDSRQGGWIDPFLEGLCKYLSFSKLRVKADLK-QGDLLNSSNL 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 122 VSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTG 201
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 202 QRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYY 281
Cdd:PLN00181  566 QLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYY 645

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 282 DLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYC------LRSFKGHINEKNFVGLASNGDYIAC 355
Cdd:PLN00181  646 DLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIAT 725

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561041 356 GSENNSLYLYYKGLSKTLLTFKFDTVKSVldKDRKEDDTNEFVSAVCWRA 405
Cdd:PLN00181  726 GSETNEVFVYHKAFPMPVLSYKFKTIDPV--SGLEVDDASQFISSVCWRG 773
 
Name Accession Description Interval E-value
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 52-405 1.12e-104

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 328.97  E-value: 1.12e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041  52 ASRRKRLTAHFEDLEQCYFSTRMSRIS----------DDSRTASQLDEFQECLSKFTRYNSVRPLATLSyASDLYNGSSI 121
Cdd:PLN00181  407 AAAEKPLARYYSALSENGRSSEKSSMSnpakppdfyiNDSRQGGWIDPFLEGLCKYLSFSKLRVKADLK-QGDLLNSSNL 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 122 VSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTG 201
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 202 QRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYY 281
Cdd:PLN00181  566 QLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYY 645

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 282 DLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYC------LRSFKGHINEKNFVGLASNGDYIAC 355
Cdd:PLN00181  646 DLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIAT 725

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561041 356 GSENNSLYLYYKGLSKTLLTFKFDTVKSVldKDRKEDDTNEFVSAVCWRA 405
Cdd:PLN00181  726 GSETNEVFVYHKAFPMPVLSYKFKTIDPV--SGLEVDDASQFISSVCWRG 773
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 119-365 2.39e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 2.39e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 119 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVD-IHYpenemtcnSKISCISWSSYHKNLLASSdYEGTVILWD 197
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHT--------GPVRDVAASADGTYLASGS-SDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 198 GFTGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADH 276
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTF-VASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 277 CVHYYDLRNTKqPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIAC 355
Cdd:cd00200   158 TIKLWDLRTGK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         250
                  ....*....|
gi 1034561041 356 GSENNSLYLY 365
Cdd:cd00200   237 GSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
106-384 2.40e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 2.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 106 LATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT--VIQdAVDIHypenemtcNSKISCISWSSyHKNL 183
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkLLR-TLTGH--------SGAVTSVAFSP-DGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 184 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFS 262
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsVRSVAFS 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 263 PSSRYhLAFGCADHCVHYYDLrNTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK 341
Cdd:COG2319   256 PDGRL-LASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1034561041 342 NFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFK--FDTVKSV 384
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTghTGAVTSV 378
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 200-240 1.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034561041  200 TGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 240
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
201-240 9.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034561041 201 GQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 240
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 52-405 1.12e-104

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 328.97  E-value: 1.12e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041  52 ASRRKRLTAHFEDLEQCYFSTRMSRIS----------DDSRTASQLDEFQECLSKFTRYNSVRPLATLSyASDLYNGSSI 121
Cdd:PLN00181  407 AAAEKPLARYYSALSENGRSSEKSSMSnpakppdfyiNDSRQGGWIDPFLEGLCKYLSFSKLRVKADLK-QGDLLNSSNL 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 122 VSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVDIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGTVILWDGFTG 201
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 202 QRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYY 281
Cdd:PLN00181  566 QLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYY 645

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 282 DLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYC------LRSFKGHINEKNFVGLASNGDYIAC 355
Cdd:PLN00181  646 DLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHTNVKNFVGLSVSDGYIAT 725

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561041 356 GSENNSLYLYYKGLSKTLLTFKFDTVKSVldKDRKEDDTNEFVSAVCWRA 405
Cdd:PLN00181  726 GSETNEVFVYHKAFPMPVLSYKFKTIDPV--SGLEVDDASQFISSVCWRG 773
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 119-365 2.39e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 2.39e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 119 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTVIQDAVD-IHYpenemtcnSKISCISWSSYHKNLLASSdYEGTVILWD 197
Cdd:cd00200     9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLkGHT--------GPVRDVAASADGTYLASGS-SDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 198 GFTGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADH 276
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwVNSVAFSPDGTF-VASSSQDG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 277 CVHYYDLRNTKqPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIAC 355
Cdd:cd00200   158 TIKLWDLRTGK-CVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         250
                  ....*....|
gi 1034561041 356 GSENNSLYLY 365
Cdd:cd00200   237 GSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
106-384 2.40e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 2.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 106 LATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT--VIQdAVDIHypenemtcNSKISCISWSSyHKNL 183
Cdd:COG2319   107 LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgkLLR-TLTGH--------SGAVTSVAFSP-DGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 184 LASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFS 262
Cdd:COG2319   177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGsVRSVAFS 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 263 PSSRYhLAFGCADHCVHYYDLrNTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEK 341
Cdd:COG2319   256 PDGRL-LASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1034561041 342 NFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFK--FDTVKSV 384
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTghTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
104-365 1.37e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.37e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 104 RPLATLSyasdlyNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT-VIQDAVDIHypenemtcNSKISCISWSSyHKN 182
Cdd:COG2319   153 KLLRTLT------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATgKLLRTLTGH--------TGAVRSVAFSP-DGK 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 183 LLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKF 261
Cdd:COG2319   218 LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGgVNSVAF 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 262 SPSSRYhLAFGCADHCVHYYDLrNTKQPIMVFKGHRKAVSYAKFVS-GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINE 340
Cdd:COG2319   297 SPDGKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374

                         250       260
                  ....*....|....*....|....*
gi 1034561041 341 KNFVGLASNGDYIACGSENNSLYLY 365
Cdd:COG2319   375 VTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-365 4.32e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 4.32e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 106 LATLSYASDLYNGSSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTViqdavdihYPENEMTC-NSKISCISWSSyHKNLL 184
Cdd:cd00200    38 LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--------ECVRTLTGhTSYVSSVAFSP-DGRIL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 185 ASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEA-KANVCCVKFSP 263
Cdd:cd00200   109 SSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSP 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 264 SSRyHLAFGCADHCVHYYDLRnTKQPIMVFKGHRKAVSYAKF-VSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKN 342
Cdd:cd00200   188 DGE-KLLSSSSDGTIKLWDLS-TGKCLGTLRGHENGVNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                         250       260
                  ....*....|....*....|...
gi 1034561041 343 FVGLASNGDYIACGSENNSLYLY 365
Cdd:cd00200   266 SLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
183-384 1.62e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 1.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 183 LLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKF 261
Cdd:COG2319    92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAF 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 262 SPSSRYhLAFGCADHCVHYYDLRnTKQPIMVFKGHRKAVSYAKFvS--GEEIVSASTDSQLKLWNVGKPYCLRSFKGHIN 339
Cdd:COG2319   171 SPDGKL-LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAF-SpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1034561041 340 EKNFVGLASNGDYIACGSENNSLYLY--YKGLSKTLLTFKFDTVKSV 384
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTGHSGGVNSV 294
WD40 COG2319
WD40 repeat [General function prediction only];
119-325 1.25e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 119 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDT-VIQDAVDIHypenemtcNSKISCISWSSYHKnLLASSDYEGTVILWD 197
Cdd:COG2319   204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLATgKLLRTLTGH--------SGSVRSVAFSPDGR-LLASGSADGTVRLWD 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 198 GFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADH 276
Cdd:COG2319   275 LATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGaVRSVAFSPDGKT-LASGSDDG 352

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034561041 277 CVHYYDLrNTKQPIMVFKGHRKAVSYAKFVS-GEEIVSASTDSQLKLWNV 325
Cdd:COG2319   353 TVRLWDL-ATGELLRTLTGHTGAVTSVAFSPdGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-324 1.25e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 1.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 122 VSSIEFDRDCDYFAIAGVTKKIKVYeydtviqdavDIHYPENEMTCNSK---ISCISWSSYHKnLLASSDYEGTVILWDG 198
Cdd:cd00200    96 VSSVAFSPDGRILSSSSRDKTIKVW----------DVETGKCLTTLRGHtdwVNSVAFSPDGT-FVASSSQDGTIKLWDL 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 199 FTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEAKAN-VCCVKFSPSSRYhLAFGCADHC 277
Cdd:cd00200   165 RTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYL-LASGSEDGT 242

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034561041 278 VHYYDLRnTKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWN 324
Cdd:cd00200   243 IRVWDLR-TGECVQTLSGHTNSVTSLAWSpDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
183-365 1.65e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 1.65e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 183 LLASSDYEGTVILWDGFTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTNLDNSVASIEA-KANVCCVKF 261
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGhTGAVRSVAF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 262 SPSSRYhLAFGCADHCVHYYDLRnTKQPIMVFKGHRKAVSYAKFVS-GEEIVSASTDSQLKLWNVGKPYCLRSFKGHINE 340
Cdd:COG2319   129 SPDGKT-LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 206

                         170       180
                  ....*....|....*....|....*
gi 1034561041 341 KNFVGLASNGDYIACGSENNSLYLY 365
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 204-365 1.46e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.46e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 204 SKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWSTNLDNSVASIE-AKANVCCVKFSPSSRYhLAFGCADHCVHYYD 282
Cdd:cd00200     2 RRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASADGTY-LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 283 LrNTKQPIMVFKGHRKAVSYAKFVSGEEIV-SASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNS 361
Cdd:cd00200    80 L-ETGECVRTLTGHTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158


                  ....
gi 1034561041 362 LYLY 365
Cdd:cd00200   159 IKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
119-242 9.06e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 9.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 119 SSIVSSIEFDRDCDYFAIAGVTKKIKVYEYDTviQDAVDIHYPENEMtcnskISCISWSSYHKnLLASSDYEGTVILWDG 198
Cdd:COG2319   288 SGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHTGA-----VRSVAFSPDGK-TLASGSDDGTVRLWDL 359

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034561041 199 FTGQRSKVYQEHEKRCWSVDFNLmDPKLLASGSDDAKVKLWSTN 242
Cdd:COG2319   360 ATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
223-365 3.24e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034561041 223 DPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSY 302
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034561041 303 AKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLY 365
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 200-240 1.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034561041  200 TGQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 240
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
201-240 9.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 9.13e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034561041 201 GQRSKVYQEHEKRCWSVDFNlMDPKLLASGSDDAKVKLWS 240
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 286-324 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.18e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034561041  286 TKQPIMVFKGHRKAVSYAKFV-SGEEIVSASTDSQLKLWN 324
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH