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dynein regulatory complex protein 8 isoform X15 [Homo sapiens]
EF-hand domain-containing protein( domain architecture ID 1000080)
EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
PTZ00184 super family | cl33172 | calmodulin; Provisional |
17-135 | 6.62e-17 | |||
calmodulin; Provisional The actual alignment was detected with superfamily member PTZ00184: Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 72.10 E-value: 6.62e-17
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Name | Accession | Description | Interval | E-value | |||
PTZ00184 | PTZ00184 | calmodulin; Provisional |
17-135 | 6.62e-17 | |||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 72.10 E-value: 6.62e-17
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EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
28-91 | 3.58e-05 | |||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 39.07 E-value: 3.58e-05
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EF-hand_6 | pfam13405 | EF-hand domain; |
28-57 | 1.62e-03 | |||
EF-hand domain; Pssm-ID: 463869 [Multi-domain] Cd Length: 30 Bit Score: 34.07 E-value: 1.62e-03
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FRQ1 | COG5126 | Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; |
27-135 | 8.29e-03 | |||
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; Pssm-ID: 444056 [Multi-domain] Cd Length: 137 Bit Score: 34.38 E-value: 8.29e-03
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Name | Accession | Description | Interval | E-value | |||
PTZ00184 | PTZ00184 | calmodulin; Provisional |
17-135 | 6.62e-17 | |||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 72.10 E-value: 6.62e-17
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PTZ00183 | PTZ00183 | centrin; Provisional |
27-135 | 7.77e-12 | |||
centrin; Provisional Pssm-ID: 185503 [Multi-domain] Cd Length: 158 Bit Score: 58.93 E-value: 7.77e-12
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EFh | cd00051 | EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ... |
28-91 | 3.58e-05 | |||
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers. Pssm-ID: 238008 [Multi-domain] Cd Length: 63 Bit Score: 39.07 E-value: 3.58e-05
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ELC_N | cd22949 | N-terminal domain of Myosin essential light chain ELC; ELC is part of the apicomplexan ... |
28-72 | 1.21e-03 | |||
N-terminal domain of Myosin essential light chain ELC; ELC is part of the apicomplexan membrane-associated protein complex called the glideosome, which is essential for parasite motility. The glideosome is composed of six proteins: myosin A (MyoA), essential light chain ELC, myosin light chain MLC1 (also called MTIP), and the glideosome-associated proteins GAP40, GAP45, and GAP50. MyoA is a Class XIV myosin implicated in gliding motility, as well as host cell and tissue invasion by parasites. ELC binds to the MyoA neck region adjacent to the MLC1-binding site, and both myosin light chains co-located to the glideosome. Although ELCs bind to a conserved MyoA sequence, P. falciparum ELC adopts a distinct structure in the free and MyoA-bound state. Therefore ELCs enhance MyoA performance by inducing alpha helical structure formation in MyoA and thus stiffening its lever arm. It has been shown that disruption of MyoA, MLC1, or ELC have dramatic effects on parasite motility but do not affect parasite shape or replication. The ELC N-terminal domain is part of the EF-hand calcium binding motif superfamily. Calcium binding has no effect on the structure of ELCs. Pssm-ID: 439385 [Multi-domain] Cd Length: 66 Bit Score: 35.02 E-value: 1.21e-03
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EF-hand_6 | pfam13405 | EF-hand domain; |
28-57 | 1.62e-03 | |||
EF-hand domain; Pssm-ID: 463869 [Multi-domain] Cd Length: 30 Bit Score: 34.07 E-value: 1.62e-03
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PTZ00184 | PTZ00184 | calmodulin; Provisional |
28-91 | 6.02e-03 | |||
calmodulin; Provisional Pssm-ID: 185504 [Multi-domain] Cd Length: 149 Bit Score: 34.74 E-value: 6.02e-03
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FRQ1 | COG5126 | Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; |
27-135 | 8.29e-03 | |||
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; Pssm-ID: 444056 [Multi-domain] Cd Length: 137 Bit Score: 34.38 E-value: 8.29e-03
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Blast search parameters | ||||
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