|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
496-1127 |
4.61e-43 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 170.04 E-value: 4.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 496 FQDYLLMD-TVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPFMNLTALIILvGIGADD 573
Cdd:COG1033 212 IAEAIQSDlAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLgLMG--LLGIPLSPLTILVPPLLL-AIGIDY 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 574 AFVLcdVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLP 653
Cdd:COG1033 289 GIHL--LNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 654 AVVVLheryllniftcFKKPQQQiydnkscwtvacqkcHKVLFAISEASRIFfeKVLPCIVIKFRYLWLFWFLALTVGGA 733
Cdd:COG1033 367 ALLSL-----------LPRPKPK---------------TRRLKKPPELGRLL--AKLARFVLRRPKVILVVALVLAVVSL 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 734 YIVcinPKMKLPSLELSEfqvFRSSHPFeRYDAEYkklfmFERVHHGEelhMPITVIwgvspedngnplnpkskgkLTLD 813
Cdd:COG1033 419 YGI---SRLKVEYDFEDY---LPEDSPI-RQDLDF-----IEENFGGS---DPLEVV-------------------VDTG 464
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 814 SSFNIASPASQAWILHFCQKLRNQTFFYQTdeQDFTScFIETFKQWMENQDCDEPALypccshwsfPYKQEIFELcikra 893
Cdd:COG1033 465 EPDGLKDPEVLKEIDRLQDYLESLPEVGKV--LSLAD-LVKELNQALNEGDPKYYAL---------PESRELLAQ----- 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 894 imelerstGYHLDSKTPGPRFD--INDTIRAVVLefqSTYLFTLAYEKMHQFYKEVDSWISSELssAPEGLSngWFVS-- 969
Cdd:COG1033 528 --------LLLLLSSPPGDDLSrfVDEDYSAARV---TVRLKDLDSEEIKALVEEVRAFLAENF--PPDGVE--VTLTgs 592
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 970 NLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLS 1049
Cdd:COG1033 593 AVLFAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIG 672
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 1050 VDFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFF 1127
Cdd:COG1033 673 VDYTIHFLSRYReeRRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL 752
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
435-1131 |
2.39e-27 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 120.54 E-value: 2.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 435 DFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWnsSDGVTTITGIEFGIKHSLFQDYLLM---DTVYPAIAI 511
Cdd:pfam02460 144 DFEPPGNISYAKAIVLWYFLKFDEEEVEEDSKEWEDELSQL--LHNKYASEHIQFTIFHDQILNDELVrnaLTLTPFFVI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 512 VIVLLVM-----CVYTKSMFITLMT------MFAIISSL--IVSYFLYRVVFHFEFFPFMNLTALIILvGIGADDAFVLC 578
Cdd:pfam02460 222 GFFLLLTfsiivSVTLSSYTIDWVRskpilaALGLLSPVmaIVSSFGLLFWMGFPFNSIVCVTPFLVL-AIGVDDMFLMV 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 579 DVWNYTKfdkPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:pfam02460 301 AAWQRTT---ATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAI 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 659 HERYLLN----IFTCFKKPQQQIYDNKScwtvACQKCHKVlfaISEASRIFFEKVLPCIV-IKFRYLWLFWF---LALTV 730
Cdd:pfam02460 378 CAKPEAEgrhcLFVWATSSPQRIDSEGS----EPDKSHNI---EQLKSRFFLDIYCPFLLnPSVRVCMLVLFvvyIAIAI 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 731 GGayivCINPKMklpslELSEFQVFRSSHPFerydAEYKKLFMFERVHHGEELHMPITviwgvSPEDNGNPLNPKSKGKL 810
Cdd:pfam02460 451 YG----CVNIKE-----GLEPDKLVLEDSPL----VEYLSLREKHFWPEGLQIQVAVN-----NPPNLTIPESRDRMNEM 512
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 811 TLD---SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDftSCFIETFKQWMEnqdcdepalYPCCSHWSfpykqeife 887
Cdd:pfam02460 513 VDEfenTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK--EWSYGNLPSFLK---------APGNSHWA--------- 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 888 lcikraimelerstGYHLdsktpgprFDINDTIravvlefQSTYLFTLAYEKMHQFYKEVDSW--ISSELSSAPEgLSNG 965
Cdd:pfam02460 573 --------------GDLV--------WDDNTTM-------VTKFRFTLAGKGLSTWNDRTRALqeWRSIADQYPE-FNVT 622
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 966 WFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVA 1045
Cdd:pfam02460 623 VFDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMS 702
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 1046 VGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVagAMMMPSTVLAYTQLGTF--MMLIMCISWAFA 1123
Cdd:pfam02460 703 IGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTIL--GVLVLLFVPSYMVVVFFktVFLVVAIGLLHG 780
|
730
....*....|.
gi 1034562741 1124 TFF---FQCMC 1131
Cdd:pfam02460 781 LFIlpiILSLF 791
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
974-1127 |
2.21e-16 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 84.91 E-value: 2.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 974 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1053
Cdd:COG1033 210 GDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034562741 1054 VHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVA-GAMM-MPSTVLAytQLGTFMMLIMCISWAFATFFF 1127
Cdd:COG1033 290 IHLLNRYReeRRKGLDKREALREALRKLGPPVLLTSLTTAIGfLSLLfSDIPPIR--DFGIVAAIGVLLAFLTSLTLL 365
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
508-662 |
8.37e-15 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 79.90 E-value: 8.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYrvVFHFEFFPfMNLTALIILVGIGADDAFVLcdVWNYTKF 586
Cdd:COG1033 612 LLALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFgLMG--LLGIPLNI-ATAVVASIALGIGVDYTIHF--LSRYREE 686
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034562741 587 DKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 662
Cdd:COG1033 687 RRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPR 762
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
507-671 |
8.97e-14 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 70.30 E-value: 8.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 507 PAIAIVIVLLVMCVYTKSMfiTLMTMFAIISSLIVSyflyrvvfhfEFFPFmnltaliILVGIGADDAFVLCDVWNYTKF 586
Cdd:pfam12349 6 FGLGLAGVIIVLASVASSL--GLCAYFGLPLTLIIS----------EVIPF-------LVLAIGVDNIFLLVKAVVRTPR 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 587 DKPhaeTSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHER----Y 662
Cdd:pfam12349 67 SLD---VSERIAEALGEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRrlesN 143
|
....*....
gi 1034562741 663 LLNIFTCFK 671
Cdd:pfam12349 144 RLDVACCIR 152
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
979-1125 |
1.31e-09 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 63.09 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 979 SLSDGTLIAMGLSvavaFSVMLLTTWNIIISLYAIISIAGTIFVtvGSLVLLGWELNVLESVT-ISVA-----VGLSVDF 1052
Cdd:TIGR03480 266 TVSEGATVAGLLS----FVLVLVLLWLALRSPRLVFAVLVTLIV--GLILTAAFATLAVGHLNlISVAfavlfIGLGVDF 339
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034562741 1053 AVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWaFATF 1125
Cdd:TIGR03480 340 AIQFSLRYReeRFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIAL-FVTL 413
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
455-1083 |
1.48e-09 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 63.00 E-value: 1.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 455 FSPTEKGESMM---NIYLDNFENWNSSDGVTTITgieFGIKHSLfQDYLLMDTVYPAIAIVIVLLVMCVYT--------- 522
Cdd:TIGR00917 522 VNKTNKTEKAVaweKAFIQLAKDELLPMVQATIS---FSAERSI-EDELKRESTADVITIAISYLVMFAYIsltlgdspr 597
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 523 -KSMFITLMTMFAIISSLIVsyfLYRVVFHFEFFPFMNLTALIILV--------GIGADDAFVLCDVWNYTKF------- 586
Cdd:TIGR00917 598 lKSLYVTSKVLLGLSGILIV---MLSVLGSVGVFSAVGLKSTLIIMevipflvlAVGVDNIFILVFFYFYLEYfyrqvgv 674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 587 DKPHAETSE-TVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HER 661
Cdd:TIGR00917 675 DNEQELTLErRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLdfkrTED 754
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 662 YLLNIFTCFKKPQQQIYDNKSCwTVACQKCHKVLFAISEASRIFFEKVLPCIVIkfrylwlFWFLALTVGGAYIVCINP- 740
Cdd:TIGR00917 755 KRVDCFPCIKTSKSSISAEKGS-GQRKAGLLTRYFKEVYAPVLLHWIVKIVVIA-------FFVGLLMAGIALSTRVEIg 826
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 741 ---KMKLPSleLSEFQVFRSShpFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNpkskgklTLDSSFN 817
Cdd:TIGR00917 827 ldqQIVLPQ--DSYLQIYFAS--LTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN-------VFNNLSY 895
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 818 IASPASqAWILHF-----------CQKLRNQTFFYQTDEQDFtSCFIET-----------FKQWMENQDCDEPAlyPCCS 875
Cdd:TIGR00917 896 IAKPAS-SWLDDYlvwlspqasccCRKFTNGTFCNGPDPQCF-RCADLSsdaqgrpsttqFKEKLPWFLNALPS--ADCA 971
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 876 HWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPgprfdiNDTIRAVvlefQSTYLFTlayekmhqfykevdswissel 955
Cdd:TIGR00917 972 KGGHAAYSSAVDLQGYATIIQASSFRTYHTPLNTQ------VDFINAM----RAAQEFA--------------------- 1020
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 956 SSAPEGLSNGWFVSNL--EFYDLQDSLSDGTLIAMGLSVAVAFSV-MLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGW 1032
Cdd:TIGR00917 1021 AKVSRSSKMEVYPYSVfyVFFEQYLTIWKTAIINLSIALGAIFIVcLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSI 1100
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|.
gi 1034562741 1033 ELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAM 1083
Cdd:TIGR00917 1101 SLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSV 1151
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
452-658 |
1.22e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 59.85 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 452 SMLFSPTEKgESMMNIYLDNFENWNSSDGVT-TITG--IEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVmcVY---TKSM 525
Cdd:TIGR00921 519 QVQLKQGEP-KVQGRKILRDVQHEHPPPGVKvGVTGlpVAFAEMHELVNEGMRRMTIAGAILVLMILLA--VFrnpIKAV 595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 526 FiTLMTMFAIISSLIVSYFLYRVVFhfeffpFMNLTALI-ILVGIGADDAFVLCDvwnytKFDKPHAETS--ETVSITLQ 602
Cdd:TIGR00921 596 F-PLIAIGSGILWAIGLMGLRGIPS------FLAMATTIsIILGLGMDYSIHLAE-----RYFEERKEHGpkEAITHTME 663
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034562741 603 HAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:TIGR00921 664 RTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
975-1111 |
1.46e-07 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 55.38 E-value: 1.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 975 DLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGwELNVLE----SVTISVAVGLSV 1050
Cdd:pfam03176 135 DLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILA-HILGIGlstfALNLLVVLLIAV 213
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034562741 1051 --DFAVHYGVAYR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 1111
Cdd:pfam03176 214 gtDYALFLVSRYReeLRAGEDREEAVIRAVRGTGKVVTAAGLT--VAIAML----ALSFARLPVF 272
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
508-674 |
5.50e-07 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 54.59 E-value: 5.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEF-----FPFMNLTALIIlvGIGADDAFVLcdVWN 582
Cdd:TIGR00833 180 ATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLigvnaQTTVLLTALVI--GAGTDYAVFL--TGR 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 583 YTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERY 662
Cdd:TIGR00833 256 YHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAVTLTPALLTLEGRE 335
|
170
....*....|..
gi 1034562741 663 LLniftcFKKPQ 674
Cdd:TIGR00833 336 GL-----MKPGR 342
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
972-1110 |
6.70e-07 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 54.00 E-value: 6.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 972 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLV--------LLGWELNVLESVT-- 1041
Cdd:COG2409 507 VNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVlvfqhgwlLLGFTPGPLDSFVpl 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 1042 --ISVAVGLSVDfavhYGV--------AYRLAPDPdREGkVIFSLSRVGS-----AMAMAAltTFVAgamMMPSTVLAYT 1106
Cdd:COG2409 587 llFVILFGLGMD----YEVflvsrireEYDRGGGT-REA-VIRGLARTGRvitsaALIMAA--VFAA---FATSPLVFLK 655
|
....
gi 1034562741 1107 QLGT 1110
Cdd:COG2409 656 QIGF 659
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
508-658 |
1.16e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 50.00 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSY-FLYRVVFHFeffpfmNL--TALIIL-VGIGADDA--FVLcdvw 581
Cdd:TIGR03480 276 LLSFVLVLVLLWLALRSPRLVFAVLVTLIVGLILTAaFATLAVGHL------NLisVAFAVLfIGLGVDFAiqFSL---- 345
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034562741 582 NYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:TIGR03480 346 RYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRL 422
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
508-658 |
1.21e-05 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 49.21 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPfMNLTAL----IILVGIGADDAFVLcdVWNY 583
Cdd:pfam03176 149 AVTLVVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIG-LSTFALnllvVLLIAVGTDYALFL--VSRY 225
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034562741 584 TKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL 658
Cdd:pfam03176 226 REELRAGEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLAL 300
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1043-1127 |
1.96e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 49.47 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 1043 SVAVGLSVDFAVHYGVAYRLAPDPDREgkviFSLSRVGSAMAMAALTTFVAGAMMM--PSTVLAytQLGTFMMLIMCISW 1120
Cdd:COG4258 310 SSLIGVAVDYSLHYLTHRRAAGEWDPR----AALRRIWPTLLLGLLTTVLGYLALLfsPFPGLR--QLGVFAAAGLLAAA 383
|
....*..
gi 1034562741 1121 AFATFFF 1127
Cdd:COG4258 384 LTTLLWL 390
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
973-1125 |
2.33e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 49.07 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 973 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDF 1052
Cdd:TIGR00921 558 FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDY 637
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034562741 1053 AVHygVAYRLAPDPDREGKV---IFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGtFMMLIMCISWAFATF 1125
Cdd:TIGR00921 638 SIH--LAERYFEERKEHGPKeaiTHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG-LVQGIGVLSSLTAAL 710
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
556-673 |
4.22e-05 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 48.34 E-value: 4.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 556 PFMNLtaliilvGIGADDAFVLCDVWNYTKFDKPHAETSETVsitLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGV 635
Cdd:TIGR00918 464 PFLAL-------GVGVDDVFLLAHAFSETGQNIPFEERTGEC---LKRTGASVVLTSISNVTAFFMAALIPIPALRAFSL 533
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1034562741 636 YAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
Cdd:TIGR00918 534 QAAIVVVFNFAAVLLVFPAILSLdlrrREDRRLDIFCCFFSP 575
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
508-660 |
7.40e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 47.52 E-value: 7.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 508 AIAIVIVLLVMCVYTKSMFITLMTMFAIISSlivsyflyrVVFHFEFFPFM-------NLTALIILVGIGAD-DAFVLcd 579
Cdd:TIGR00921 200 AISGILVVLVLLLDFKRWWRPLLPLVIILFG---------VAWVLGIMGWLgiplyatTLLAVPMLIGVGIDyGIQTL-- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 580 vwnyTKFDKPHAE---TSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVV 656
Cdd:TIGR00921 269 ----NRYEEERDIgraKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALL 344
|
....
gi 1034562741 657 VLHE 660
Cdd:TIGR00921 345 QSID 348
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
988-1090 |
6.57e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.46 E-value: 6.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 988 MGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHygvayrLAPDPD 1067
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALF------FTEGLL 718
|
90 100
....*....|....*....|...
gi 1034562741 1068 REGkvifSLSRVGSAMAMAALTT 1090
Cdd:COG4258 719 DKG----ELARTLLSILLAALTT 737
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
974-1117 |
7.91e-04 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 44.06 E-value: 7.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 974 YDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1053
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034562741 1054 VHYGVAYRlapDPDREGK-----VIFSLSRVGSAMAMAALTTfVAGAMMMPSTVLAYTQ---LGTFMMLIMC 1117
Cdd:TIGR00921 265 IQTLNRYE---EERDIGRakgeaIVTAVRRTGRAVLIALLTT-SAGFAALALSEFPMVSefgLGLVAGLITA 332
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
973-1111 |
8.70e-04 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 43.99 E-value: 8.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 973 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVlESVTISVAV----GL 1048
Cdd:COG2409 160 AADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDV-SSFAPNLLTmlglGV 238
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034562741 1049 SVDFAVHYgVA-YR--LAPDPDREGKVIFSLSRVGSAMAMAALTtfVAGAMMmpstVLAYTQLGTF 1111
Cdd:COG2409 239 GIDYALFL-VSrYReeLRAGEDREEAVARAVATAGRAVLFSGLT--VAIALL----GLLLAGLPFL 297
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
985-1124 |
2.90e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 42.10 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 985 LIAMGLSVAVAFSVMLLTTWNIIISLYA-IISIAGTifvtvgSLVLLGWE-LNVLE------SVTISVAVGLSVDFAVHY 1056
Cdd:cd13134 134 LQALSLTLSAILRSHGRTKIPMYVSLIMnILNIVGN------YLLIFGWFgLPKLGvagvaiSTVISRAVGLVLLFILLF 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 1057 ---GVAYRLAPDPDREGKVIFSLSRVG--SA-------MAMAALTTFVAgamMMPSTVLA-YTQLGTFMMLIMCISWAFA 1123
Cdd:cd13134 208 rklKIRFRLKDLRPFPKKLLKKILKIGlpSAgeelsynLSQTVITAFIA---RLGTAALAaRTYASNISMFVFLFSLAIG 284
|
.
gi 1034562741 1124 T 1124
Cdd:cd13134 285 Q 285
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
994-1128 |
4.00e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 41.91 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 994 VAFSVMLLTTW-NIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDregkv 1072
Cdd:TIGR03480 723 VAITVLLLLTLrRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHRWRNGVDSG----- 797
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034562741 1073 ifslSRVGSAMAMA----ALTTFVA-GAMMMPStvlaytQLGTFMM-LIMCISWAF---ATFFFQ 1128
Cdd:TIGR03480 798 ----NLLQSSTARAvffsALTTATAfGSLAVSS------HPGTASMgILLSLGLGLtllCTLIFL 852
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
985-1100 |
9.25e-03 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 40.64 E-value: 9.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562741 985 LIAMGLSVAVAF---SVMLLTTWNIIISLYAIISIAGTIFvtvGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYr 1061
Cdd:TIGR00918 968 LLSISVVLACTFlvcALLLLNPWTAGLIVLVLALMTVELF---GMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGF- 1043
|
90 100 110
....*....|....*....|....*....|....*....
gi 1034562741 1062 LAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
Cdd:TIGR00918 1044 LTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGS 1082
|
|
| |
