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Conserved domains on  [gi|1034612324|ref|XP_016859050|]
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von Willebrand factor A domain-containing protein 3B isoform X6 [Homo sapiens]

Protein Classification

VWA domain-containing protein; VWA domain-containing protein; vWA domain-containing protein( domain architecture ID 10077493)

VWA (von Willebrand factor type A) domain-containing protein similar to mammalian von Willebrand factor that plays an essential role in the formation of a platelet plug, to stop bleeding, by anchoring blood platelets to the damaged vessel wall under conditions of high shear stress; VWA (von Willebrand factor type A) domain-containing protein; VWA (von Willebrand factor type A) domain-containing protein similar to mammalian von Willebrand factor that plays an essential role in the formation of a platelet plug, to stop bleeding, by anchoring blood platelets to the damaged vessel wall under conditions of high shear stress; VWA (von Willebrand factor type A) domain-containing protein similar to mammalian von Willebrand factor that plays an essential role in the formation of a platelet plug, to stop bleeding, by anchoring blood platelets to the damaged vessel wall under conditions of high shear stress; VWA (von Willebrand factor type A) domain-containing protein, similar to Dictyostelium discoideum integrin beta-like protein A and mammalian calcium-activated chloride channel regulator; VWA (von Willebrand factor type A) domain-containing protein with an extracellular solute-binding protein (SBP) domain; VWA (von Willebrand factor type A) domain-containing protein, similar to Dictyostelium discoideum integrin beta-like protein A and mammalian calcium-activated chloride channel regulator; VWA (von Willebrand factor type A) domain-containing protein; VWA (von Willebrand factor type A) domain-containing protein similar to Bos taurus von Willebrand factor A domain-containing protein 7; VWA (von Willebrand factor type A) domain-containing protein similar to mammalian von Willebrand factor that plays an essential role in the formation of a platelet plug, to stop bleeding, by anchoring blood platelets to the damaged vessel wall under conditions of high shear stress; VWA (von Willebrand factor type A) domain-containing protein with C-terminal prealbumin-like fold domain that is similar to Corynebacterium diphtheriae domain 1 and domain 3 of surface-anchored protein fimbrial subunit SpaA; VWA (von Willebrand factor type A) domain-containing protein; VWA (von Willebrand factor type A) domain-containing protein similar to Bos taurus von Willebrand factor A domain-containing protein 7; VWA (von Willebrand factor type A) domain-containing protein; VWA (von Willebrand factor type A) domain-containing protein similar to Bos taurus von Willebrand factor A domain-containing protein 7; VWA (von Willebrand factor type A) domain-containing protein, similar to Dictyostelium discoideum integrin beta-like protein A and mammalian calcium-activated chloride channel regulator; VWA (von Willebrand factor type A) domain-containing protein; VWA (von Willebrand factor type A) domain-containing protein similar to mammalian von Willebrand factor that plays an essential role in the formation of a platelet plug, to stop bleeding, by anchoring blood platelets to the damaged vessel wall under conditions of high shear stress; VWA (von Willebrand factor type A) domain-containing protein; VWA (von Willebrand factor type A) domain-containing protein with C-terminal prealbumin-like fold domain that is similar to bacterial pilin adhesin subunit SpaC; von Willebrand factor type A (vWA) domain containing protein, often found at C-terminus of CalY family proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4537 pfam15057
Domain of unknown function (DUF4537); The function of this domain family is unknown. It is ...
 694-820 1.65e-43

Domain of unknown function (DUF4537); The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.


:

Pssm-ID: 464475 [Multi-domain]  Cd Length: 124  Bit Score: 153.62  E-value: 1.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 694 GQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVSTSFITPVGGAMpCPLLQVGDYVFAKiVIPKGFDfYVPAI 773
Cdd:pfam15057   1 GQRVLARWDEDGFYYRGTVKKYLNGGQYLVEFDAGDRQVVLTRDIIALEDAM-EHPLRVGDKVLAL-HDPYSQS-YAPGI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034612324 774 VIALPNKHVATEKFYTVLKCNNRREFCPRSALIKISQNKYALSCSHI 820
Cdd:pfam15057  78 VLAGPERRVDADEELTVRFYDGKTATVPREEVYKLSQAYYEKAVAYI 124
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 166-315 1.13e-19

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


:

Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 90.00  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSM--KSKLDLVKDKIIQFIQEQLKyKSKFNFVKFDGQAvawrEQLAEVNEDnLEQAQSWIRDIKIGSSTNT 243
Cdd:COG1240    95 VVLVVDASGSMaaENRLEAAKGALLDFLDDYRP-RDRVGLVAFGGEA----EVLLPLTRD-REALKRALDELPPGGGTPL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 244 LSALKTA------FADKETQAIYLLTDGRPDQPPETVIDQVKRFQE--IPIYTISFNyNDEIANRFLKEVAALTGGEFHF 315
Cdd:COG1240   169 GDALALAlellkrADPARRKVIVLLTDGRDNAGRIDPLEAAELAAAagIRIYTIGVG-TEAVDEGLLREIAEATGGRYFR 247
 
Name Accession Description Interval E-value
DUF4537 pfam15057
Domain of unknown function (DUF4537); The function of this domain family is unknown. It is ...
 694-820 1.65e-43

Domain of unknown function (DUF4537); The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.


Pssm-ID: 464475 [Multi-domain]  Cd Length: 124  Bit Score: 153.62  E-value: 1.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 694 GQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVSTSFITPVGGAMpCPLLQVGDYVFAKiVIPKGFDfYVPAI 773
Cdd:pfam15057   1 GQRVLARWDEDGFYYRGTVKKYLNGGQYLVEFDAGDRQVVLTRDIIALEDAM-EHPLRVGDKVLAL-HDPYSQS-YAPGI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034612324 774 VIALPNKHVATEKFYTVLKCNNRREFCPRSALIKISQNKYALSCSHI 820
Cdd:pfam15057  78 VLAGPERRVDADEELTVRFYDGKTATVPREEVYKLSQAYYEKAVAYI 124
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 166-315 1.13e-19

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 90.00  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSM--KSKLDLVKDKIIQFIQEQLKyKSKFNFVKFDGQAvawrEQLAEVNEDnLEQAQSWIRDIKIGSSTNT 243
Cdd:COG1240    95 VVLVVDASGSMaaENRLEAAKGALLDFLDDYRP-RDRVGLVAFGGEA----EVLLPLTRD-REALKRALDELPPGGGTPL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 244 LSALKTA------FADKETQAIYLLTDGRPDQPPETVIDQVKRFQE--IPIYTISFNyNDEIANRFLKEVAALTGGEFHF 315
Cdd:COG1240   169 GDALALAlellkrADPARRKVIVLLTDGRDNAGRIDPLEAAELAAAagIRIYTIGVG-TEAVDEGLLREIAEATGGRYFR 247
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 165-316 2.99e-19

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 85.70  E-value: 2.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 165 CIYILIDTSHSM-KSKLDLVKDKIIQFIQ--EQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDiKIGSST 241
Cdd:cd00198     2 DIVFLLDVSGSMgGEKLDKAKEALKALVSslSASPPGDRVGLVTFGSNARVVLPLTTDTDKADLLEAIDALKK-GLGGGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 242 NTLSALKTAFA-------DKETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGGeFH 314
Cdd:cd00198    81 NIGAALRLALEllksakrPNARRVIILLTDGEPNDGPELLAEAARELRKLGITVYTIGIGDDANEDELKEIADKTTG-GA 159


                  ..
gi 1034612324 315 FY 316
Cdd:cd00198   160 VF 161
VWA_3 pfam13768
von Willebrand factor type A domain;
166-315 2.05e-14

von Willebrand factor type A domain;


Pssm-ID: 372716 [Multi-domain]  Cd Length: 155  Bit Score: 71.66  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSMKSKLDLVKDKIIQFIQeQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSS-TNTL 244
Cdd:pfam13768   3 VVIVVDVSSSMSGEPKLQKDALSVALR-QLPTGDKFAVLGFGTLPRPLFPGWRVVSPRSLQEAFQFIKTLQPPLGgSDLL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034612324 245 SALKTAFADKETQA----IYLLTDGRPDQPPETVIDQVKRFQE-IPIYTISFnyNDEIANRFLKEVAALTGGEFHF 315
Cdd:pfam13768  82 GALKEAVRAPASPGyirhVLLLTDGSPMQGETRVSDLISRAPGkIRFFAYGL--GASISAPMLQLLAEASNGTYEF 155
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 166-318 5.04e-11

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 5.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324  166 IYILIDTSHSM-KSKLDLVKDKIIQFIQ--EQLKYKSKFNFVKFDGQAvawREQLAEVNEDNLEQAQSWIRDIKI--GSS 240
Cdd:smart00327   2 VVFLLDGSGSMgGNRFELAKEFVLKLVEqlDIGPDGDRVGLVTFSDDA---RVLFPLNDSRSKDALLEALASLSYklGGG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324  241 TNTLSALKTAFA----------DKETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTG 310
Cdd:smart00327  79 TNLGAALQYALEnlfsksagsrRGAPKVVILITDGESNDGPKDLLKAAKELKRSGVKVFVVGVGNDVDEEELKKLASAPG 158


                   ....*...
gi 1034612324  311 GEFHFYNF 318
Cdd:smart00327 159 GVYVFLPE 166
acidobact_VWFA TIGR03436
VWFA-related Acidobacterial domain; Members of this family are bacterial domains that include ...
 168-317 6.73e-05

VWFA-related Acidobacterial domain; Members of this family are bacterial domains that include a region related to the von Willebrand factor type A (VWFA) domain (pfam00092). These domains are restricted to, and have undergone a large paralogous family expansion in, the Acidobacteria, including Solibacter usitatus and Acidobacterium capsulatum ATCC 51196.


Pssm-ID: 274577 [Multi-domain]  Cd Length: 296  Bit Score: 45.76  E-value: 6.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 168 ILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAV------AWREQLaevnEDNLEQAQSWIRDIKIGSST 241
Cdd:TIGR03436  58 LVIDTSGSMRNDLDRARAAAIRFLKTVLRPNDRVFVVTFNTRLRllqdftSDPRLL----EAALNRLKPPLRTDYNSSGA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 242 NTLSALKTAFADketqAIYL---------------------LTDG---RPDQPPETVIDQVKRfQEIPIYTISF---NYN 294
Cdd:TIGR03436 134 FVRDGGGTALYD----AITLaaleqlanalagipgrkalivISDGgdnRSRDTLERAIDAAQR-ADVAIYSIDArglRAP 208

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1034612324 295 DEIANR--------FLKEVAALTGGEFHFYN 317
Cdd:TIGR03436 209 DLGAGAkaglggpeALERLAEETGGRAFYVN 239
Tudor_53BP1 cd20383
Tudor domain found in tumor suppressor TP53-binding protein 1 (53BP1) and similar proteins; ...
 694-734 2.57e-03

Tudor domain found in tumor suppressor TP53-binding protein 1 (53BP1) and similar proteins; 53BP1, also called p53-binding protein 1 (p53BP1), is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics, and class-switch recombination (CSR) during antibody genesis. It plays a key role in the repair of DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. It is recruited to DSB sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSB sites. 53BP1 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410454  Cd Length: 52  Bit Score: 36.86  E-value: 2.57e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034612324 694 GQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVS 734
Cdd:cd20383     2 GTRVFAKWSSDGYYYPGIITRVLGDGKYKVLFDDGYERDVK 42
 
Name Accession Description Interval E-value
DUF4537 pfam15057
Domain of unknown function (DUF4537); The function of this domain family is unknown. It is ...
 694-820 1.65e-43

Domain of unknown function (DUF4537); The function of this domain family is unknown. It is found in eukaryotes, and is typically between 119 and 141 amino acids in length. In humans, it is found in the chromosomal position C11orf16.


Pssm-ID: 464475 [Multi-domain]  Cd Length: 124  Bit Score: 153.62  E-value: 1.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 694 GQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVSTSFITPVGGAMpCPLLQVGDYVFAKiVIPKGFDfYVPAI 773
Cdd:pfam15057   1 GQRVLARWDEDGFYYRGTVKKYLNGGQYLVEFDAGDRQVVLTRDIIALEDAM-EHPLRVGDKVLAL-HDPYSQS-YAPGI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034612324 774 VIALPNKHVATEKFYTVLKCNNRREFCPRSALIKISQNKYALSCSHI 820
Cdd:pfam15057  78 VLAGPERRVDADEELTVRFYDGKTATVPREEVYKLSQAYYEKAVAYI 124
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
 166-315 1.13e-19

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 90.00  E-value: 1.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSM--KSKLDLVKDKIIQFIQEQLKyKSKFNFVKFDGQAvawrEQLAEVNEDnLEQAQSWIRDIKIGSSTNT 243
Cdd:COG1240    95 VVLVVDASGSMaaENRLEAAKGALLDFLDDYRP-RDRVGLVAFGGEA----EVLLPLTRD-REALKRALDELPPGGGTPL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 244 LSALKTA------FADKETQAIYLLTDGRPDQPPETVIDQVKRFQE--IPIYTISFNyNDEIANRFLKEVAALTGGEFHF 315
Cdd:COG1240   169 GDALALAlellkrADPARRKVIVLLTDGRDNAGRIDPLEAAELAAAagIRIYTIGVG-TEAVDEGLLREIAEATGGRYFR 247
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 165-316 2.99e-19

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 85.70  E-value: 2.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 165 CIYILIDTSHSM-KSKLDLVKDKIIQFIQ--EQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDiKIGSST 241
Cdd:cd00198     2 DIVFLLDVSGSMgGEKLDKAKEALKALVSslSASPPGDRVGLVTFGSNARVVLPLTTDTDKADLLEAIDALKK-GLGGGT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 242 NTLSALKTAFA-------DKETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGGeFH 314
Cdd:cd00198    81 NIGAALRLALEllksakrPNARRVIILLTDGEPNDGPELLAEAARELRKLGITVYTIGIGDDANEDELKEIADKTTG-GA 159


                  ..
gi 1034612324 315 FY 316
Cdd:cd00198   160 VF 161
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
 168-315 7.09e-17

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 82.07  E-value: 7.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 168 ILIDTSHSMK-SKLDLVKDKIIQFIqEQLKYKSKFNFVKFDGQAvawREQLAEVNEDNLEQAQSWIRDIKIGSSTNTLSA 246
Cdd:COG2304    96 FVIDVSGSMSgDKLELAKEAAKLLV-DQLRPGDRVSIVTFAGDA---RVLLPPTPATDRAKILAAIDRLQAGGGTALGAG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 247 LKTA-------FADKETQAIYLLTDGRPD---QPPETVIDQVKRFQE--IPIYTISF--NYNDEianrFLKEVAALTGGE 312
Cdd:COG2304   172 LELAyelarkhFIPGRVNRVILLTDGDANvgiTDPEELLKLAEEAREegITLTTLGVgsDYNED----LLERLADAGGGN 247


                  ...
gi 1034612324 313 FHF 315
Cdd:COG2304   248 YYY 250
VWA_3 pfam13768
von Willebrand factor type A domain;
166-315 2.05e-14

von Willebrand factor type A domain;


Pssm-ID: 372716 [Multi-domain]  Cd Length: 155  Bit Score: 71.66  E-value: 2.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSMKSKLDLVKDKIIQFIQeQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSS-TNTL 244
Cdd:pfam13768   3 VVIVVDVSSSMSGEPKLQKDALSVALR-QLPTGDKFAVLGFGTLPRPLFPGWRVVSPRSLQEAFQFIKTLQPPLGgSDLL 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034612324 245 SALKTAFADKETQA----IYLLTDGRPDQPPETVIDQVKRFQE-IPIYTISFnyNDEIANRFLKEVAALTGGEFHF 315
Cdd:pfam13768  82 GALKEAVRAPASPGyirhVLLLTDGSPMQGETRVSDLISRAPGkIRFFAYGL--GASISAPMLQLLAEASNGTYEF 155
vWA_interalpha_trypsin_inhibitor cd01461
vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- ...
 169-314 4.50e-12

vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to the extracellular matrix by binding to hyaluronic acid. The heavy chains carry the VWA domain with a conserved MIDAS motif. Although the exact role of the VWA domains remains unknown, it has been speculated to be involved in mediating protein-protein interactions with the components of the extracellular matrix.


Pssm-ID: 238738 [Multi-domain]  Cd Length: 171  Bit Score: 65.31  E-value: 4.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 169 LIDTSHSMKS-KLDLVKDKIIQFIQEqLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAQSWIRDIKIGSSTNTLSAL 247
Cdd:cd01461     8 VIDTSGSMSGtKIEQTKEALLTALKD-LPPGDYFNIIGFSDTVEEFSPSSVSATAENVAAAIEYVNRLQALGGTNMNDAL 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034612324 248 KTAFADKET-----QAIYLLTDGRPDQpPETVIDQVKRF--QEIPIYTISFNyNDeiANRFLKEVAALTGGEFH 314
Cdd:cd01461    87 EAALELLNSspgsvPQIILLTDGEVTN-ESQILKNVREAlsGRIRLFTFGIG-SD--VNTYLLERLAREGRGIA 156
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
 166-306 6.56e-12

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 67.01  E-value: 6.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSMK-SKLDLVKDKIIQFIQEQLKyKSKFNFVKFDGQAVawrEQLAEVNEDNLEQAQSWIRDIKIGSSTNTL 244
Cdd:COG2425   121 VVLCVDTSGSMAgSKEAAAKAAALALLRALRP-NRRFGVILFDTEVV---EDLPLTADDGLEDAIEFLSGLFAGGGTDIA 196

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034612324 245 SALKTAFADKETQA-----IYLLTDGRPDQPPETVIDQVK-RFQEIPIYTISFnyNDEIANRFLKEVA 306
Cdd:COG2425   197 PALRAALELLEEPDyrnadIVLITDGEAGVSPEELLREVRaKESGVRLFTVAI--GDAGNPGLLEALA 262
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
 166-318 5.04e-11

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 62.47  E-value: 5.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324  166 IYILIDTSHSM-KSKLDLVKDKIIQFIQ--EQLKYKSKFNFVKFDGQAvawREQLAEVNEDNLEQAQSWIRDIKI--GSS 240
Cdd:smart00327   2 VVFLLDGSGSMgGNRFELAKEFVLKLVEqlDIGPDGDRVGLVTFSDDA---RVLFPLNDSRSKDALLEALASLSYklGGG 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324  241 TNTLSALKTAFA----------DKETQAIYLLTDGRPDQPPETVIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTG 310
Cdd:smart00327  79 TNLGAALQYALEnlfsksagsrRGAPKVVILITDGESNDGPKDLLKAAKELKRSGVKVFVVGVGNDVDEEELKKLASAPG 158


                   ....*...
gi 1034612324  311 GEFHFYNF 318
Cdd:smart00327 159 GVYVFLPE 166
VWA pfam00092
von Willebrand factor type A domain;
166-318 1.86e-10

von Willebrand factor type A domain;


Pssm-ID: 459670 [Multi-domain]  Cd Length: 174  Bit Score: 60.75  E-value: 1.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSM-KSKLDLVKDKIIQFIQ--EQLKYKSKFNFVKFDGQAvawrEQLAEVNED-NLEQAQSWIRDIKI--GS 239
Cdd:pfam00092   2 IVFLLDGSGSIgGDNFEKVKEFLKKLVEslDIGPDGTRVGLVQYSSDV----RTEFPLNDYsSKEELLSAVDNLRYlgGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 240 STNTLSALKTA----FADKE------TQAIYLLTDGRP-DQPPETVIDQVKRFQeIPIYTISFNYNDeiaNRFLKEVaAL 308
Cdd:pfam00092  78 TTNTGKALKYAlenlFSSAAgarpgaPKVVVLLTDGRSqDGDPEEVARELKSAG-VTVFAVGVGNAD---DEELRKI-AS 152

                         170
                  ....*....|
gi 1034612324 309 TGGEFHFYNF 318
Cdd:pfam00092 153 EPGEGHVFTV 162
TerY COG4245
Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];
160-289 2.44e-06

Uncharacterized conserved protein YegL, contains vWA domain of TerY type [Function unknown];


Pssm-ID: 443387 [Multi-domain]  Cd Length: 196  Bit Score: 49.15  E-value: 2.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 160 RLHndcIYILIDTSHSMK-SKLDLVKDKIIQFIQEQLKYKS-----KFNFVKFDGQAvawrEQLAEVNEdnLEQAQswIR 233
Cdd:COG4245     5 RLP---VYLLLDTSGSMSgEPIEALNEGLQALIDELRQDPYaletvEVSVITFDGEA----KVLLPLTD--LEDFQ--PP 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034612324 234 DIKIGSSTNTLSALKTAFA--DKETQA------------IYLLTDGRP-DQPPETVIDQVKRFQEIPIYTI 289
Cdd:COG4245    74 DLSASGGTPLGAALELLLDliERRVQKytaegkgdwrpvVFLITDGEPtDSDWEAALQRLKDGEAAKKANI 144
vWA_subgroup cd01465
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 169-316 2.55e-06

VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.


Pssm-ID: 238742 [Multi-domain]  Cd Length: 170  Bit Score: 48.42  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 169 LIDTSHSMKS-KLDLVKDKIIQFIqEQLKYKSKFNFVKFDG--------QAVAWREQLAEVnednleqaqswIRDIKIGS 239
Cdd:cd01465     6 VIDRSGSMDGpKLPLVKSALKLLV-DQLRPDDRLAIVTYDGaaetvlpaTPVRDKAAILAA-----------IDRLTAGG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 240 STNTLSALKTA-------FADKETQAIYLLTDGRP---DQPPETVIDQV--KRFQEIPIYTISF--NYNDEianrfLKEV 305
Cdd:cd01465    74 STAGGAGIQLGyqeaqkhFVPGGVNRILLATDGDFnvgETDPDELARLVaqKRESGITLSTLGFgdNYNED-----LMEA 148

                         170
                  ....*....|.
gi 1034612324 306 AALTGGEFHFY 316
Cdd:cd01465   149 IADAGNGNTAY 159
vWA_complement_factors cd01470
Complement factors B and C2 are two critical proteases for complement activation. They both ...
 166-316 2.56e-05

Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred commonly as the MIDAS motif. Orthologues of these molecules are found from echinoderms to chordates. During complement activation, the CCP domains are cleaved off, resulting in the formation of an active protease that cleaves and activates complement C3. Complement C2 is in the classical pathway and complement B is in the alternative pathway. The interaction of C2 with C4 and of factor B with C3b are both dependent on Mg2+ binding sites within the VWA domains and the VWA domain of factor B has been shown to mediate the binding of C3. This is consistent with the common inferred function of VWA domains as magnesium-dependent protein interaction domains.


Pssm-ID: 238747 [Multi-domain]  Cd Length: 198  Bit Score: 46.13  E-value: 2.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSM-KSKLDLVKDKIIQFIQEQLKYKSKFNF--VKFDGQAV-------AWREQLAEVNEdNLEQAQSWIRDI 235
Cdd:cd01470     3 IYIALDASDSIgEEDFDEAKNAIKTLIEKISSYEVSPRYeiISYASDPKeivsirdFNSNDADDVIK-RLEDFNYDDHGD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 236 KIGssTNTLSALKTAF------------ADKETQ-AIYLLTDGRPDQ--PPETVIDQVKRFqeIPIYTIS---------- 290
Cdd:cd01470    82 KTG--TNTAAALKKVYermalekvrnkeAFNETRhVIILFTDGKSNMggSPLPTVDKIKNL--VYKNNKSdnpredyldv 157

                         170       180
                  ....*....|....*....|....*...
gi 1034612324 291 --FNYNDEIANRFLKEVAALTGGEFHFY 316
Cdd:cd01470   158 yvFGVGDDVNKEELNDLASKKDNERHFF 185
vWA_C3HC4_type cd01466
VWA C3HC4-type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
 169-315 3.81e-05

VWA C3HC4-type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Membes of this subgroup belong to Zinc-finger family as they are found fused to RING finger domains. The MIDAS motif is not conserved in all the members of this family. The function of vWA domains however is not known.


Pssm-ID: 238743 [Multi-domain]  Cd Length: 155  Bit Score: 44.69  E-value: 3.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 169 LIDTSHSMKS-KLDLVKDKIiQFIQEQLKYKSKFNFVKFDGQAvAWREQLAEVNEDNLEQAQSWIRDIKIGSSTNTLSAL 247
Cdd:cd01466     6 VLDVSGSMAGdKLQLVKHAL-RFVISSLGDADRLSIVTFSTSA-KRLSPLRRMTAKGKRSAKRVVDGLQAGGGTNVVGGL 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034612324 248 KTAFA---DKETQ----AIYLLTDGRPDQppetvIDQVKRFQEIPIYTISFNYNDEIANRFLKEVAALTGGEFHF 315
Cdd:cd01466    84 KKALKvlgDRRQKnpvaSIMLLSDGQDNH-----GAVVLRADNAPIPIHTFGLGASHDPALLAFIAEITGGTFSY 153
acidobact_VWFA TIGR03436
VWFA-related Acidobacterial domain; Members of this family are bacterial domains that include ...
 168-317 6.73e-05

VWFA-related Acidobacterial domain; Members of this family are bacterial domains that include a region related to the von Willebrand factor type A (VWFA) domain (pfam00092). These domains are restricted to, and have undergone a large paralogous family expansion in, the Acidobacteria, including Solibacter usitatus and Acidobacterium capsulatum ATCC 51196.


Pssm-ID: 274577 [Multi-domain]  Cd Length: 296  Bit Score: 45.76  E-value: 6.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 168 ILIDTSHSMKSKLDLVKDKIIQFIQEQLKYKSKFNFVKFDGQAV------AWREQLaevnEDNLEQAQSWIRDIKIGSST 241
Cdd:TIGR03436  58 LVIDTSGSMRNDLDRARAAAIRFLKTVLRPNDRVFVVTFNTRLRllqdftSDPRLL----EAALNRLKPPLRTDYNSSGA 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 242 NTLSALKTAFADketqAIYL---------------------LTDG---RPDQPPETVIDQVKRfQEIPIYTISF---NYN 294
Cdd:TIGR03436 134 FVRDGGGTALYD----AITLaaleqlanalagipgrkalivISDGgdnRSRDTLERAIDAAQR-ADVAIYSIDArglRAP 208

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1034612324 295 DEIANR--------FLKEVAALTGGEFHFYN 317
Cdd:TIGR03436 209 DLGAGAkaglggpeALERLAEETGGRAFYVN 239
vWFA_subfamily_ECM cd01450
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 166-316 3.62e-04

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains


Pssm-ID: 238727 [Multi-domain]  Cd Length: 161  Bit Score: 42.28  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSM-KSKLDLVKDKIIQFIQ--EQLKYKSKFNFVKFDGQAVAWREQLAEVNEDNLEQAqswIRDIKI--GSS 240
Cdd:cd01450     3 IVFLLDGSESVgPENFEKVKDFIEKLVEklDIGPDKTRVGLVQYSDDVRVEFSLNDYKSKDDLLKA---VKNLKYlgGGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 241 TNTLSALKTAFA---------DKETQAIYLLTDGRP--DQPPETVIDQVKRFQeIPIYTISFNYNDEianRFLKEVAAlT 309
Cdd:cd01450    80 TNTGKALQYALEqlfsesnarENVPKVIIVLTDGRSddGGDPKEAAAKLKDEG-IKVFVVGVGPADE---EELREIAS-C 154


                  ....*..
gi 1034612324 310 GGEFHFY 316
Cdd:cd01450   155 PSERHVF 161
Tudor_53BP1 cd20383
Tudor domain found in tumor suppressor TP53-binding protein 1 (53BP1) and similar proteins; ...
 694-734 2.57e-03

Tudor domain found in tumor suppressor TP53-binding protein 1 (53BP1) and similar proteins; 53BP1, also called p53-binding protein 1 (p53BP1), is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics, and class-switch recombination (CSR) during antibody genesis. It plays a key role in the repair of DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. It is recruited to DSB sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSB sites. 53BP1 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410454  Cd Length: 52  Bit Score: 36.86  E-value: 2.57e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034612324 694 GQKVIARCDENGFYFPGVVKKCVSRTQALVGFSYGDTKVVS 734
Cdd:cd20383     2 GTRVFAKWSSDGYYYPGIITRVLGDGKYKVLFDDGYERDVK 42
VWA_2 pfam13519
von Willebrand factor type A domain;
166-252 8.77e-03

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 36.89  E-value: 8.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034612324 166 IYILIDTSHSM------KSKLDLVKDKIIQFIQeQLKyKSKFNFVKFDGQAvawrEQLAEVNEDNlEQAQSWIRDIKIGS 239
Cdd:pfam13519   1 LVFVLDTSGSMrngdygPTRLEAAKDAVLALLK-SLP-GDRVGLVTFGDGP----EVLIPLTKDR-AKILRALRRLEPKG 73

                          90
                  ....*....|....
gi 1034612324 240 -STNTLSALKTAFA 252
Cdd:pfam13519  74 gGTNLAAALQLARA 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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