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Conserved domains on  [gi|1034633534|ref|XP_016861974|]
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plasma membrane calcium-transporting ATPase 2 isoform X3 [Homo sapiens]

Protein Classification

plasma membrane calcium-transporting ATPase( domain architecture ID 13522140)

plasma membrane calcium-transporting ATPase functions to export Ca(2+) from cells and plays a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca super family cl36924
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1087 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


The actual alignment was detected with superfamily member TIGR01517:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1311.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgvkkgdglqlpaadgaaasnaadsa 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQ------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  328 naslvngkmqdgnvdasqskakqqdgaaamemqplksaEGGDaddrkkasmhkkeKSVLQGKLTKLAVQIGKAGLVMSAI 407
Cdd:TIGR01517  271 --------------------------------------AGEE-------------ETPLQEKLSELAGLIGKFGMGSAVL 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  408 TVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDAC 487
Cdd:TIGR01517  300 LFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAAC 376
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  488 ETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSINTKTMELLINAIAINSayttkILPPEKE-GALPRQ 564
Cdd:TIGR01517  377 ETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNLPAAVRNILVEGISLNS-----SSEEVVDrGGKRAF 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  565 VGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGE 644
Cdd:TIGR01517  452 IGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGE 531
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  645 PRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAG 724
Cdd:TIGR01517  532 ATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAG 607
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  725 ITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKGII 804
Cdd:TIGR01517  608 ITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLK 677
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  805 DsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 884
Cdd:TIGR01517  678 D-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLT 752
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  885 VNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQ 962
Cdd:TIGR01517  753 VNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQ 832
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  963 LALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAI 1042
Cdd:TIGR01517  833 LVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGF 911
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*
gi 1034633534 1043 QIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1087
Cdd:TIGR01517  912 QVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1126-1168 5.54e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 61.27  E-value: 5.54e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633534 1126 GQILWFRGLNRIQTQIEVVNTFKSGA--SFQGALRRQS--SVTSQSQ 1168
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLreGIQKPYLRNSihSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1087 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1311.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgvkkgdglqlpaadgaaasnaadsa 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQ------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  328 naslvngkmqdgnvdasqskakqqdgaaamemqplksaEGGDaddrkkasmhkkeKSVLQGKLTKLAVQIGKAGLVMSAI 407
Cdd:TIGR01517  271 --------------------------------------AGEE-------------ETPLQEKLSELAGLIGKFGMGSAVL 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  408 TVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDAC 487
Cdd:TIGR01517  300 LFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAAC 376
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  488 ETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSINTKTMELLINAIAINSayttkILPPEKE-GALPRQ 564
Cdd:TIGR01517  377 ETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNLPAAVRNILVEGISLNS-----SSEEVVDrGGKRAF 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  565 VGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGE 644
Cdd:TIGR01517  452 IGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGE 531
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  645 PRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAG 724
Cdd:TIGR01517  532 ATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAG 607
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  725 ITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKGII 804
Cdd:TIGR01517  608 ITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLK 677
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  805 DsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 884
Cdd:TIGR01517  678 D-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLT 752
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  885 VNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQ 962
Cdd:TIGR01517  753 VNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQ 832
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  963 LALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAI 1042
Cdd:TIGR01517  833 LVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGF 911
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*
gi 1034633534 1043 QIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1087
Cdd:TIGR01517  912 QVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-951 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1304.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081     66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgvkkgdglq 311
Cdd:cd02081    145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRA-------------------- 204
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  312 lpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmHKKEKSVLQGKLT 391
Cdd:cd02081    205 -------------------------------------------------------------------ENEEKTPLQEKLT 217
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  392 KLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWlpecTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSV 471
Cdd:cd02081    218 KLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSV 293
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  472 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGdvhykeipdpssintktmellinaiainsayttk 551
Cdd:cd02081    294 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYIG---------------------------------- 339
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  552 ilppekegalprqvgNKTECGLLGFVLDLKQDYePVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIV 631
Cdd:cd02081    340 ---------------NKTECALLGFVLELGGDY-RYREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIV 403
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  632 LKKCCKILNGAGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEP----DWDNENDILNELTCICVVGIED 707
Cdd:cd02081    404 LKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKD 482
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  708 PVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRV 787
Cdd:cd02081    483 PLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRV 562
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  788 LARSSPTDKHTLVKGIIDSthteqRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMW 867
Cdd:cd02081    563 LARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMW 637
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  868 GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLI 947
Cdd:cd02081    638 GRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLI 717

                   ....
gi 1034633534  948 SRTM 951
Cdd:cd02081    718 SRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1081 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 662.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474     12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474     77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474    132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  274 TAVGVNSQTGIIFTLLGAGgeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdg 353
Cdd:COG0474    212 VATGMNTEFGKIAKLLQEA------------------------------------------------------------- 230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  354 aaamemqplksaeggdaddrkkasmhKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYftvdtfvvnKKPWLpect 433
Cdd:COG0474    231 --------------------------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLLR---------GGPLL---- 271
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  434 pvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ 513
Cdd:COG0474    272 --------EALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVER 343
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  514 AYVGDVHYkeipDPSSINTKTMELLINAIAINSAYTtkiLPPEKEgalprqVGNKTECGLLGFVLDLKQDYEPVRSQMPe 593
Cdd:COG0474    344 VYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP- 409
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  594 ekLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTIC 673
Cdd:COG0474    410 --RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVLTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLA 485
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  674 VAYRDFPSSPEPDwdnENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGED 753
Cdd:COG0474    486 VAYKELPADPELD---SEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR 562
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  754 flCLEGKEFNRrirneKGEIE-QERIDKIwpklRVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKK 830
Cdd:COG0474    563 --VLTGAELDA-----MSDEElAEAVEDV----DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKA 624
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  831 ADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQM 910
Cdd:COG0474    625 ADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQI 704
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  911 LWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSp 990
Cdd:COG0474    705 LWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALAR- 778
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  991 psehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWC 1067
Cdd:COG0474    779 -----TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLI 851
                         1050
                   ....*....|....
gi 1034633534 1068 IFIGLGELVWGQVI 1081
Cdd:COG0474    852 LGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
903-1081 2.72e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 172.81  E-value: 2.72e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  903 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 982
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  983 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1060
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1034633534 1061 LDQWMWCIFIGLGELVWGQVI 1081
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-893 6.26e-39

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 157.54  E-value: 6.26e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517    53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517   118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517   173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  267 GSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmQDGNVDASQS 346
Cdd:PRK10517   253 GTAQAVVIATGANTWFGQLAGRVSE---------------------------------------------QDSEPNAFQQ 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  347 KAKqqdgaaamemqplksaeggdaddrkKASMhkkeksvlqgKLTKLAvqigkagLVMSAitVIILVLYFTvdtfvvnKK 426
Cdd:PRK10517   288 GIS-------------------------RVSW----------LLIRFM-------LVMAP--VVLLINGYT-------KG 316
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  427 PWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT 506
Cdd:PRK10517   317 DW------------WEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQ 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  507 NRMtVVQAYVgDVHYKeipdpssintKTMELLINAIaINSAYTTKIlppekEGALPRQVgnkTECGLLGFVLDLKQDYEP 586
Cdd:PRK10517   385 DKI-VLENHT-DISGK----------TSERVLHSAW-LNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQK 443
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  587 VrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMA 665
Cdd:PRK10517   444 I-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLN 510
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  666 CDGLRTICVAYRDFPSSPEpDWD--NENDilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAI 743
Cdd:PRK10517   511 RQGLRVVAVATKYLPAREG-DYQraDESD----LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCH 585
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  744 KCGIIHPGedflCLEGkefnrrirnekGEIEQ---ERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGD 820
Cdd:PRK10517   586 EVGLDAGE----VLIG-----------SDIETlsdDELANLAERTTLFARLTPMHKERIVTLLKREGH-----VVGFMGD 645
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034633534  821 GTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 893
Cdd:PRK10517   646 GINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1126-1168 5.54e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 61.27  E-value: 5.54e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633534 1126 GQILWFRGLNRIQTQIEVVNTFKSGA--SFQGALRRQS--SVTSQSQ 1168
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLreGIQKPYLRNSihSFMSHPE 47
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
12-1087 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1311.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   12 KNQRNESSHGGEFGCTMEELRSLMELRGTEAV---VKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFIP 88
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFkkaMPLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   89 PKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHP-PGEGNEgcataqggaedegEAEAGWIEGAAILLSVICVVLV 167
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPsVGEDKA-------------DTETGWIEGVAILVSVILVVLV 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  168 TAFNDWSKEKQFRGLQsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQ 247
Cdd:TIGR01517  148 TAVNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDP 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  248 VRKSVDKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgvkkgdglqlpaadgaaasnaadsa 327
Cdd:TIGR01517  227 IKKGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQ------------------------------------ 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  328 naslvngkmqdgnvdasqskakqqdgaaamemqplksaEGGDaddrkkasmhkkeKSVLQGKLTKLAVQIGKAGLVMSAI 407
Cdd:TIGR01517  271 --------------------------------------AGEE-------------ETPLQEKLSELAGLIGKFGMGSAVL 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  408 TVIILVLYFTVDTFVVNKKPwlpECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDAC 487
Cdd:TIGR01517  300 LFLVLSLRYVFRIIRGDGRF---EDTEEDAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAAC 376
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  488 ETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPD--PSSINTKTMELLINAIAINSayttkILPPEKE-GALPRQ 564
Cdd:TIGR01517  377 ETMGSATAICSDKTGTLTQNVMSVVQGYIGEQRFNVRDEivLRNLPAAVRNILVEGISLNS-----SSEEVVDrGGKRAF 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  565 VGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGAGE 644
Cdd:TIGR01517  452 IGSKTECALLDFGLLLLLQSRDVQEVRAEEKVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGE 531
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  645 PRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENdilNELTCICVVGIEDPVRPEVPEAIRKCQRAG 724
Cdd:TIGR01517  532 ATPISEDDKDR-CADVIEPLASDALRTICLAYRDFAPEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAG 607
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  725 ITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKGII 804
Cdd:TIGR01517  608 ITVRMVTGDNIDTAKAIARNCGILTFGG--LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVLMLK 677
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  805 DsthteQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 884
Cdd:TIGR01517  678 D-----MGEVVAVTGDGTNDAPALKLADVGFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLT 752
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  885 VNVVAVIVAFTGACIT--QDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQ 962
Cdd:TIGR01517  753 VNVVAVILTFVGSCISssHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQ 832
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  963 LALIFTLLFVGEKMFQIDSGRNAPlHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAI 1042
Cdd:TIGR01517  833 LVVTFILLFAGGSIFDVSGPDEIT-SHQQGELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGF 911
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*
gi 1034633534 1043 QIVIVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTS 1087
Cdd:TIGR01517  912 QVIIVEFGGSFFSTVSLSIEQWIGCVLLGMLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
75-951 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1304.87  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   75 LEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGnegcataqggaedegEAEAGWIEG 154
Cdd:cd02081      1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEG---------------EGKTGWIEG 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  155 AAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDL 234
Cdd:cd02081     66 VAILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDL 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  235 KIDESSLTGESDQVRKSVD---KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgvkkgdglq 311
Cdd:cd02081    145 KIDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRA-------------------- 204
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  312 lpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmHKKEKSVLQGKLT 391
Cdd:cd02081    205 -------------------------------------------------------------------ENEEKTPLQEKLT 217
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  392 KLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWlpecTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSV 471
Cdd:cd02081    218 KLAVQIGKVGLIVAALTFIVLIIRFIIDGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSV 293
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  472 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGdvhykeipdpssintktmellinaiainsayttk 551
Cdd:cd02081    294 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTQNRMTVVQGYIG---------------------------------- 339
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  552 ilppekegalprqvgNKTECGLLGFVLDLKQDYePVRSQMPEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIV 631
Cdd:cd02081    340 ---------------NKTECALLGFVLELGGDY-RYREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIV 403
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  632 LKKCCKILNGAGEpRVFRPRDRDEMVKKVIEPMACDGLRTICVAYRDFPSSPEP----DWDNENDILNELTCICVVGIED 707
Cdd:cd02081    404 LKKCSYILNSDGE-VVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPtaerDWDDEEDIESDLTFIGIVGIKD 482
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  708 PVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRV 787
Cdd:cd02081    483 PLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRV 562
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  788 LARSSPTDKHTLVKGIIDSthteqRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMW 867
Cdd:cd02081    563 LARSSPEDKYTLVKGLKDS-----GEVVAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMW 637
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  868 GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLI 947
Cdd:cd02081    638 GRNVYDSIRKFLQFQLTVNVVAVILAFIGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLI 717

                   ....
gi 1034633534  948 SRTM 951
Cdd:cd02081    718 SRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
52-1081 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 662.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVtliileiaaiisL--------GLSF 123
Cdd:COG0474     12 SAEEVLAELGTSE-EGL--SSEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNP------------LilillaaaVISA 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  124 yhppgegnegcATaqggaedeGEaeagWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQI 203
Cdd:COG0474     77 -----------LL--------GD----WVDAIVILAVVLLNAIIGFVQEYRAEKALEALKKLLAP--TARVLRDGKWVEI 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  204 PVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSV----------DKDPMLLSGTHVMEGSGRMLV 273
Cdd:COG0474    132 PAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSAdplpedaplgDRGNMVFMGTLVTSGRGTAVV 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  274 TAVGVNSQTGIIFTLLGAGgeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdg 353
Cdd:COG0474    212 VATGMNTEFGKIAKLLQEA------------------------------------------------------------- 230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  354 aaamemqplksaeggdaddrkkasmhKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYftvdtfvvnKKPWLpect 433
Cdd:COG0474    231 --------------------------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLLR---------GGPLL---- 271
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  434 pvyvqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ 513
Cdd:COG0474    272 --------EALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVER 343
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  514 AYVGDVHYkeipDPSSINTKTMELLINAIAINSAYTtkiLPPEKEgalprqVGNKTECGLLGFVLDLKQDYEPVRSQMPe 593
Cdd:COG0474    344 VYTGGGTY----EVTGEFDPALEELLRAAALCSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYP- 409
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  594 ekLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGaGEPRVFRPRDRDEMVKKVIEpMACDGLRTIC 673
Cdd:COG0474    410 --RVDEIPFDSERKRMSTVHEDPDGKRLLIVKGAPEVVLALCTRVLTG-GGVVPLTEEDRAEILEAVEE-LAAQGLRVLA 485
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  674 VAYRDFPSSPEPDwdnENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGED 753
Cdd:COG0474    486 VAYKELPADPELD---SEDDESDLTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR 562
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  754 flCLEGKEFNRrirneKGEIE-QERIDKIwpklRVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKK 830
Cdd:COG0474    563 --VLTGAELDA-----MSDEElAEAVEDV----DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKA 624
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  831 ADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQM 910
Cdd:COG0474    625 ADIGIAMGITGTDVAKEAADIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQI 704
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  911 LWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGekmfqIDSGRNAPLHSp 990
Cdd:COG0474    705 LWINLVTDGLPALALGFEPVEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALA-----LARGASLALAR- 778
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  991 psehyTIIFNTFVMMQLFNEINARKIHgeRNVFD-GIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWC 1067
Cdd:COG0474    779 -----TMAFTTLVLSQLFNVFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLI 851
                         1050
                   ....*....|....
gi 1034633534 1068 IFIGLGELVWGQVI 1081
Cdd:COG0474    852 LGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
76-939 6.31e-153

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 474.02  E-value: 6.31e-153
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   76 EKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedegeaeAGWIEGA 155
Cdd:cd02089      8 ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVL---------------------------GEYVDAI 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02089     61 VIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGRLIESASLR 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  236 IDESSLTGESDQVRKSVDKDP-----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGgeeeekkdkkgv 304
Cdd:cd02089    139 VEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEET------------ 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  305 kkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmhKKEKS 384
Cdd:cd02089    207 ---------------------------------------------------------------------------EEEKT 211
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  385 VLQGKLTKLAVQIGKAGLvmsAITVIILVLYftvdtfVVNKKPWLPEctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVT 464
Cdd:cd02089    212 PLQKRLDQLGKRLAIAAL---IICALVFALG------LLRGEDLLDM------------LLTAVSLAVAAIPEGLPAIVT 270
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  465 ISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVgdvhykeIPDPSSIntktmellinAIaI 544
Cdd:cd02089    271 IVLALGVQRMAKRNAIIRKLPAVETLGSVSVICSDKTGTLTQNKMTVEKIYT-------IGDPTET----------AL-I 332
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  545 NSAYTTKILPPEKEGALPRQvgnktecgllgfvldlkqdyepvrSQMPeeklykvytFNSVRKSMSTVIKLPDEsFRMYS 624
Cdd:cd02089    333 RAARKAGLDKEELEKKYPRI------------------------AEIP---------FDSERKLMTTVHKDAGK-YIVFT 378
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  625 KGASEIVLKKCCKILNGaGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDN-ENDilneLTCICVV 703
Cdd:cd02089    379 KGAPDVLLPRCTYIYIN-GQVRPLTEEDRAK-ILAVNEEFSEEALRVLAVAYKPLDEDPTESSEDlEND----LIFLGLV 452
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  704 GIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNrrirnekgEIEQERIDKIWP 783
Cdd:cd02089    453 GMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARAIAKELGILEDGD--KALTGEELD--------KMSDEELEKKVE 522
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  784 KLRVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSI 861
Cdd:cd02089    523 QISVYARVSPEHKLRIVKAL-------QRKgkIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATI 595
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034633534  862 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKP 939
Cdd:cd02089    596 VAAVEEGRTIYDNIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
157-925 8.78e-143

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 442.91  E-value: 8.78e-143
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  157 ILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVvQIPVAEIVVGDIAQVKYGDLLPADGLFIQGnDLKI 236
Cdd:TIGR01494    2 ILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFV 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  237 DESSLTGESDQVRKSVDKDP-MLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkdkkgvkkgdglqlpaa 315
Cdd:TIGR01494   80 DESSLTGESLPVLKTALPDGdAVFAGTINFGGTLIVKVTATGILTTVGKI------------------------------ 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  316 dgaaasnaadsanaslvngkmqdgnvdasqskakqqdgAAAMemqplksaeggdaddrkKASMHkkEKSVLQGKLTKLAV 395
Cdd:TIGR01494  130 --------------------------------------AVVV-----------------YTGFS--TKTPLQSKADKFEN 152
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  396 QIGKAGLVMSAITVIILVLYFTVDTFvvnkkpwlpectpvyvqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMM 475
Cdd:TIGR01494  153 FIFILFLLLLALAVFLLLPIGGWDGN-----------------SIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMA 215
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  476 KDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINtktmellinaiainsayttkilpp 555
Cdd:TIGR01494  216 KKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEEASLALALLA------------------------ 271
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  556 ekeGALPRQVGNKTECGLLGFV-LDLKQDYEPVrsqmpEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKK 634
Cdd:TIGR01494  272 ---ASLEYLSGHPLERAIVKSAeGVIKSDEINV-----EYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLER 343
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  635 CCKILNgageprvfrprdrdemVKKVIEPMACDGLRTICVAYRDFPsspepdwdnendilNELTCICVVGIEDPVRPEVP 714
Cdd:TIGR01494  344 CNNEND----------------YDEKVDEYARQGLRVLAFASKKLP--------------DDLEFLGLLTFEDPLRPDAK 393
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  715 EAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPT 794
Cdd:TIGR01494  394 ETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID--------------------------------------VFARVKPE 435
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  795 DKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGIAgtDVAKEASDIILTDDNFSSIVKAVMWGRNVYDS 874
Cdd:TIGR01494  436 EKAAIVEALQEKGRT-----VAMTGDGVNDAPALKKADVGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSN 508
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1034633534  875 ISKFLQFQLTVNVVAVIVAFTGACItqdsplkavqmlwvNLIMDTFASLAL 925
Cdd:TIGR01494  509 IKKNIFWAIAYNLILIPLALLLIVI--------------ILLPPLLAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
151-1072 3.46e-135

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 432.07  E-value: 3.46e-135
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQkfTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02080     56 WVDAIVIFGVVLINAIIGYIQEGKAEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADLRLIE 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  231 GNDLKIDESSLTGESDQVRKSVDKDP----------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGAGGEeeekkd 300
Cdd:cd02080    134 ARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLLAEVEQ------ 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  301 kkgvkkgdgLQLPaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrkkasmhk 380
Cdd:cd02080    208 ---------LATP------------------------------------------------------------------- 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  381 keksvLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdTFVVNKKPWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLP 460
Cdd:cd02080    212 -----LTRQIAKFSKALLIVILVLAALTFVF--------GLLRGDYSL------------VELFMAVVALAVAAIPEGLP 266
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  461 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYvgdvhykeipdpssintktmeLLIN 540
Cdd:cd02080    267 AVITITLAIGVQRMAKRNAIIRRLPAVETLGSVTVICSDKTGTLTRNEMTVQAIV---------------------TLCN 325
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  541 AIAInsayttkilppEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDESf 620
Cdd:cd02080    326 DAQL-----------HQEDGHWKITGDPTEGALLVLAAKAGLDPDRLASSYPRVD---KIPFDSAYRYMATLHRDDGQR- 390
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  621 RMYSKGASEIVLKKCCKILNGAGEprvfRPRDRDEMVKKViEPMACDGLRTICVAYRDFPssPEPDWDNENDILNELTCI 700
Cdd:cd02080    391 VIYVKGAPERLLDMCDQELLDGGV----SPLDRAYWEAEA-EDLAKQGLRVLAFAYREVD--SEVEEIDHADLEGGLTFL 463
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  701 CVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdflCLEGKEFNRRIRNEKGEIEQERidk 780
Cdd:cd02080    464 GLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARAIGAQLGLGDGKK---VLTGAELDALDDEELAEAVDEV--- 537
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  781 iwpklRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSS 860
Cdd:cd02080    538 -----DVFARTSPEHKLRLVRAL-----QARGEVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFAT 607
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  861 IVKAVMWGRNVYDSISKFLQFQLTVNV---VAVIVA-FTGACItqdsPLKAVQMLWVNLIMDTFASLALATEPPTETLLL 936
Cdd:cd02080    608 IAAAVEEGRRVYDNLKKFILFTLPTNLgegLVIIVAiLFGVTL----PLTPVQILWINMVTAITLGLALAFEPAEPGIMK 683
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  937 RKPYGRNKPLISRTMMKNILGHAVYQLALIFTL-LFVGEKMFQIDSGRnaplhsppsehyTIIFNTFVMMQLFNEINARK 1015
Cdd:cd02080    684 RPPRDPSEPLLSRELIWRILLVSLLMLGGAFGLfLWALDRGYSLETAR------------TMAVNTIVVAQIFYLFNCRS 751
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534 1016 IHgeRNVFD-GIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQLDQWMWCIFIGL 1072
Cdd:cd02080    752 LH--RSILKlGVFSNKILFLGIGALILLQLAFTYlpFMNSLFGTAPIDLVDWAIILLVGI 809
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
52-948 5.82e-126

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 412.07  E-value: 5.82e-126
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   52 DTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYhppgegn 131
Cdd:cd02083      4 TVEEVLAYFGVDPTRGL--SDEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALF------- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  132 egcataqggaEDEGEAEAGWIEGAAILLSVIC--VVLVtafndWskekQFRGLQSRIEQEQKF-----TVVRAGQVVQ-I 203
Cdd:cd02083     75 ----------EEGEEGVTAFVEPFVILLILIAnaVVGV-----W----QERNAEKAIEALKEYepemaKVLRNGKGVQrI 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  204 PVAEIVVGDIAQVKYGDLLPADG--LFIQGNDLKIDESSLTGESDQVRKSVD--KDP---------MLLSGTHVMEGSGR 270
Cdd:cd02083    136 RARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVAAGKAR 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  271 MLVTAVGVNsqTGIiftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvnGKMQDgnvdasqskakq 350
Cdd:cd02083    216 GVVVGTGLN--TEI-------------------------------------------------GKIRD------------ 232
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  351 qdgaaamEMQplksaeggDADDrkkasmhkkEKSVLQGKLTKLAVQIGKAglvmsaITVI-ILVlyftvdtFVVNKKPWl 429
Cdd:cd02083    233 -------EMA--------ETEE---------EKTPLQQKLDEFGEQLSKV------ISVIcVAV-------WAINIGHF- 274
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  430 peCTPVYVQYFVK----FFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 505
Cdd:cd02083    275 --NDPAHGGSWIKgaiyYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLT 352
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  506 TNRMTVVQAYV-----GDVHYKEIP--------------DPSSINTKTMELLINAIAINSAYTTKILPPEKEGALPRQVG 566
Cdd:cd02083    353 TNQMSVSRMFIldkveDDSSLNEFEvtgstyapegevfkNGKKVKAGQYDGLVELATICALCNDSSLDYNESKGVYEKVG 432
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  567 NKTECGLLGFV------------LDLKQDYEPVRSQMpEEKLYKVYT--FNSVRKSMSTVIKLPDESF--RMYSKGASEI 630
Cdd:cd02083    433 EATETALTVLVekmnvfntdksgLSKRERANACNDVI-EQLWKKEFTleFSRDRKSMSVYCSPTKASGgnKLFVKGAPEG 511
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  631 VLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEpMACDGLRTICVAYRDFPSSPEP----DWDNENDILNELTCICVVGIE 706
Cdd:cd02083    512 VLERCTHVRVGGGKVVPLTAAIKILILKKVWG-YGTDTLRCLALATKDTPPKPEDmdleDSTKFYKYETDLTFVGVVGML 590
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  707 DPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFlclEGKEFNRRIRNEKGEIEQEridKIWPKLR 786
Cdd:cd02083    591 DPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDEDT---TGKSYTGREFDDLSPEEQR---EACRRAR 664
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  787 VLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFSSIVKAVM 866
Cdd:cd02083    665 LFSRVEPSHKSKIVELL-----QSQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVE 738
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  867 WGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPL 946
Cdd:cd02083    739 EGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPL 818

                   ..
gi 1034633534  947 IS 948
Cdd:cd02083    819 IS 820
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
142-1072 2.78e-120

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 394.92  E-value: 2.78e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  142 EDEGEAEAGWIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSrIEQEQKfTVVRAGQVVQIPVAEIVVGDIAQVKYGDL 221
Cdd:TIGR01116   27 EEGEETVTAFVEPFVILLILVANAIVGVWQERNAEKAIEALKE-YESEHA-KVLRDGRWSVIKAKDLVPGDIVELAVGDK 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  222 LPADGLFIQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGiiftllg 290
Cdd:TIGR01116  105 VPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpderavnqDKKNMLFSGTLVVAGKARGVVVRTGMSTEIG------- 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  291 aggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngKMQDGNVDASQskakqqdgaaamemqplksaeggda 370
Cdd:TIGR01116  178 --------------------------------------------KIRDEMRAAEQ------------------------- 188
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  371 ddrkkasmhkkEKSVLQGKLTKLAVQIGKaglVMSAITVIIlvlyftvdtFVVNKKPWLPECTPV-YVQYFVKFFIIGVT 449
Cdd:TIGR01116  189 -----------EDTPLQKKLDEFGELLSK---VIGLICILV---------WVINIGHFNDPALGGgWIQGAIYYFKIAVA 245
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  450 VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV----------QAYVGDV 519
Cdd:TIGR01116  246 LAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCkvvaldpsssSLNEFCV 325
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  520 H----------YKEIPDPSSINTKTMELLINAIAINSayTTKILPPEKEGALPRqVGNKTECGLLGFV--LDLKQDYEPV 587
Cdd:TIGR01116  326 TgttyapeggvIKDDGPVAGGQDAGLEELATIAALCN--DSSLDFNERKGVYEK-VGEATEAALKVLVekMGLPATKNGV 402
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  588 RS---------QMPEEKLYKVYT--FNSVRKSMSTVIKlPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEM 656
Cdd:TIGR01116  403 SSkrrpalgcnSVWNDKFKKLATleFSRDRKSMSVLCK-PSTGNKLFVKGAPEGVLERCTHILNGDGRAVPLTDKMKNTI 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  657 VKKVIEPMACDGLRTICVAYRDFPSSPE----PDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTG 732
Cdd:TIGR01116  482 LSVIKEMGTTKALRCLALAFKDIPDPREedllSDPANFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRVIMITG 561
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  733 DNINTARAIAIKCGIIHPGED--FLCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTE 810
Cdd:TIGR01116  562 DNKETAEAICRRIGIFSPDEDvtFKSFTGREFD--------EMGPAKQRAACRSAVLFSRVEPSHKSELVELL-----QE 628
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  811 QRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAV 890
Cdd:TIGR01116  629 QGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISSNIGEV 707
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  891 IVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLIS-----RTMMKNILGHAVYQLAL 965
Cdd:TIGR01116  708 VCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITgwlffRYLVVGVYVGLATVGGF 787
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  966 IFTLLFVGEKMFQIDSGRNAP--------LHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVL 1037
Cdd:TIGR01116  788 VWWYLLTHFTGCDEDSFTTCPdfedpdcyVFEGKQPARTISLSVLVVIEMFNALNALSEDQSLLRM-PPWVNKWLIGAIC 866
                          970       980       990
                   ....*....|....*....|....*....|....*..
gi 1034633534 1038 GTFAIQIVI--VQFGGKPFSCSPLQLDQWMWCIFIGL 1072
Cdd:TIGR01116  867 LSMALHFLIlyVPFLSRIFGVTPLSLTDWLMVLKLSL 903
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
151-1046 1.20e-117

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 387.97  E-value: 1.20e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd02086     56 WIEGGVIAAVIALNVIVGFIQEYKAEKTMDSLRNLSSPNAH--VIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIE 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeee 297
Cdd:cd02086    134 TKNFETDEALLTGESLPVIKDAelvfgkeedvsvgDRLNLAYSSSTVTKGRAKGIVVATGMNTEIGKIAKAL-------- 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  298 kkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqQDGAAAMEMQPLKSAEGGDADDRKKAS 377
Cdd:cd02086    206 -----------------------------------------------------RGKGGLISRDRVKSWLYGTLIVTWDAV 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  378 MH---KKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFTVDTFVVNKKpwlpectpvyvqyfvkFFIIGVTVLVVA 454
Cdd:cd02086    233 GRflgTNVGTPLQRKLSKLAY-------LLFFIAVILAIIVFAVNKFDVDNE----------------VIIYAIALAISM 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  455 VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVgdvhykeipdPSSintkt 534
Cdd:cd02086    290 IPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWI----------PAA----- 354
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  535 melLINAIAINSAyttkilppeKEGALPRQVGNKTECGLLGFV--LDLKQDYEPVRSQmPEEKLYKVYTFNSVRKSMSTV 612
Cdd:cd02086    355 ---LCNIATVFKD---------EETDCWKAHGDPTEIALQVFAtkFDMGKNALTKGGS-AQFQHVAEFPFDSTVKRMSVV 421
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  613 I--KLPDESFrMYSKGASEIVLKkCCKILNGAGEPRVFRPRDRDEMVKKViEPMACDGLRTICVAYRDF-------PSSP 683
Cdd:cd02086    422 YynNQAGDYY-AYMKGAVERVLE-CCSSMYGKDGIIPLDDEFRKTIIKNV-ESLASQGLRVLAFASRSFtkaqfndDQLK 498
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  684 EPDWDNEnDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGE--------DFL 755
Cdd:cd02086    499 NITLSRA-DAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSyhysqeimDSM 577
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  756 CLEGKEFNRrirnekgeIEQERIDKIwPKL-RVLARSSPTDKhtlVKgIIDSTHTEQRqVVAVTGDGTNDGPALKKADVG 834
Cdd:cd02086    578 VMTASQFDG--------LSDEEVDAL-PVLpLVIARCSPQTK---VR-MIEALHRRKK-FCAMTGDGVNDSPSLKMADVG 643
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  835 FAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQ 909
Cdd:cd02086    644 IAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSPVE 723
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  910 MLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILghaVYQLALIFTLL--FVGeKMFQIDSGRnapL 987
Cdd:cd02086    724 ILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTF---VYGTFMGVLCLasFTL-VIYGIGNGD---L 796
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  988 HSPPSEHYTI-----------IFNTFVMMQLF---NEINARK----IHGE-----RNVFDGIFRNP-IFCTIVLGTFAIQ 1043
Cdd:cd02086    797 GSDCNESYNSscedvfraraaVFATLTWCALIlawEVVDMRRsffnMHPDtdspvKSFFKTLWKNKfLFWSVVLGFVSVF 876

                   ...
gi 1034633534 1044 IVI 1046
Cdd:cd02086    877 PTL 879
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
156-1060 3.59e-113

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 372.50  E-value: 3.59e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  156 AILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEqkFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLK 235
Cdd:cd02085     52 SITVAILIVVTVAFVQEYRSEKSLEALNKLVPPE--CHCLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLS 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  236 IDESSLTGESDQVRKSVD-------KDPMLLS-----GTHVMEGSGRMLVTAVGVNSQTGIIFtllgaggeeeekkdkkg 303
Cdd:cd02085    130 IDESSLTGETEPCSKTTEvipkasnGDLTTRSniafmGTLVRCGHGKGIVIGTGENSEFGEVF----------------- 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  304 vkkgdglqlpaadgaaasnaadsanaslvngKMqdgnvdasqskakqqdgaaameMQplksAEggdaddrkkasmhKKEK 383
Cdd:cd02085    193 -------------------------------KM----------------------MQ----AE-------------EAPK 202
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  384 SVLQGKLTKLAVQigkaglvMSAITVIILVLYFTVDTFvvNKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLPLAV 463
Cdd:cd02085    203 TPLQKSMDKLGKQ-------LSLYSFIIIGVIMLIGWL--QGKNLL------------EMFTIGVSLAVAAIPEGLPIVV 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  464 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVhykeipdpssintktmellinaia 543
Cdd:cd02085    262 TVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTVTKIVTGCV------------------------ 317
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  544 INSAYTTKILPPekegalprqvGNKTECGLLgfVLDLKQDYEPVRSqmpEEKLYKVYTFNSVRKSMSTVIKLPDESFR-- 621
Cdd:cd02085    318 CNNAVIRNNTLM----------GQPTEGALI--ALAMKMGLSDIRE---TYIRKQEIPFSSEQKWMAVKCIPKYNSDNee 382
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  622 -MYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEmVKKVIEPMACDGLRTICVAyrdfpSSPEpdwdnendiLNELTCI 700
Cdd:cd02085    383 iYFMKGALEQVLDYCTTYNSSDGSALPLTQQQRSE-INEEEKEMGSKGLRVLALA-----SGPE---------LGDLTFL 447
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  701 CVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEdfLCLEGKEFNRrirnekgeIEQERIDK 780
Cdd:cd02085    448 GLVGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSL--QALSGEEVDQ--------MSDSQLAS 517
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  781 IWPKLRVLARSSPTDKHTLVKGIIDSThteqrQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSS 860
Cdd:cd02085    518 VVRKVTVFYRASPRHKLKIVKALQKSG-----AVVAMTGDGVNDAVALKSADIGIAMGRTGTDVCKEAADMILVDDDFST 592
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  861 IVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPY 940
Cdd:cd02085    593 ILAAIEEGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRQPPR 672
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  941 GRNKPLISRTMMKNILGHAvyqlALIFT-LLFVGEKmfQIDSGRNAPLHSppsehyTIIFNTFVMMQLFNEINARkiHGE 1019
Cdd:cd02085    673 NVKDPILTRSLILNVLLSA----AIIVSgTLWVFWK--EMSDDNVTPRDT------TMTFTCFVFFDMFNALSCR--SQT 738
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|..
gi 1034633534 1020 RNVFD-GIFRNPIFCTIVLGTFAIQIVIVQFggkpfscSPLQ 1060
Cdd:cd02085    739 KSIFEiGFFSNRMFLYAVGGSLIGQLLVIYF-------PPLQ 773
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
496-925 1.12e-96

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 311.31  E-value: 1.12e-96
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  496 ICSDKTGTLTTNRMTVVqayvgDVHYKEIPdpssintktmellinaiainsayttkilppekegalprqvgnktecgllg 575
Cdd:cd01431      2 ICSDKTGTLTKNGMTVT-----KLFIEEIP-------------------------------------------------- 26
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  576 fvldlkqdyepvrsqmpeeklykvytFNSVRKSMSTVIKLPDEsFRMYSKGASEIVLKKCCKILngageprvfrPRDRDE 655
Cdd:cd01431     27 --------------------------FNSTRKRMSVVVRLPGR-YRAIVKGAPETILSRCSHAL----------TEEDRN 69
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  656 MVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENdilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 735
Cdd:cd01431     70 KIEKAQEESAREGLRVLALAYREFDPETSKEAVELN-----LVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNP 144
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  736 NTARAIAIKCGIIHPGEDFLCLEgkefnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVV 815
Cdd:cd01431    145 LTAIAIAREIGIDTKASGVILGE----------EADEMSEEELLDLIAKVAVFARVTPEQKLRIVKALQARGE-----VV 209
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  816 AVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFT 895
Cdd:cd01431    210 AMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFAIAL 289
                          410       420       430
                   ....*....|....*....|....*....|
gi 1034633534  896 GACITQDSPLKAVQMLWVNLIMDTFASLAL 925
Cdd:cd01431    290 ALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
155-928 1.81e-88

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 299.72  E-value: 1.81e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  155 AAILLSVICV-VLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRA--GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQG 231
Cdd:cd07539     60 AVLIVGVLTVnAVIGGVQRLRAERALAAL--LAQQQQPARVVRApaGRTQTVPAESLVPGDVIELRAGEVVPADARLLEA 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  232 NDLKIDESSLTGESDQVRKSVDKDP---------MLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLGaggeeeekkdkk 302
Cdd:cd07539    138 DDLEVDESALTGESLPVDKQVAPTPgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA------------ 205
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  303 gvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdgaaamemqPLKSAEGgdaddrkkasmhkke 382
Cdd:cd07539    206 ----------------------------------------------------------PVETATG--------------- 212
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  383 ksvLQGKLTKLAVQigkaglvMSAITVIILVLYFTVDtfVVNKKPWLPectpvyvqyFVKffiIGVTVLVVAVPEGLPLA 462
Cdd:cd07539    213 ---VQAQLRELTSQ-------LLPLSLGGGAAVTGLG--LLRGAPLRQ---------AVA---DGVSLAVAAVPEGLPLV 268
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  463 VTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQayvgdvhykeipdpssintktmellinai 542
Cdd:cd07539    269 ATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRLRVVQ----------------------------- 319
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  543 ainsayttkILPPEKEgaLPrqvgnktecgllgfvldlkqdyepvrsqmpeeklykvytFNSVRKSMSTVIKLPDESFRM 622
Cdd:cd07539    320 ---------VRPPLAE--LP---------------------------------------FESSRGYAAAIGRTGGGIPLL 349
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  623 YSKGASEIVLKKCCKILNGAGePRVFRPRDRDeMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDilnELTCICV 702
Cdd:cd07539    350 AVKGAPEVVLPRCDRRMTGGQ-VVPLTEADRQ-AIEEVNELLAGQGLRVLAVAYRTLDAGTTHAVEAVVD---DLELLGL 424
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  703 VGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpGEDFLCLEGKEFNRrirnekgeIEQERIDKIW 782
Cdd:cd07539    425 LGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGL---PRDAEVVTGAELDA--------LDEEALTGLV 493
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  783 PKLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIV 862
Cdd:cd07539    494 ADIDVFARVSPEQKLQIVQALQAAGR-----VVAMTGDGANDAAAIRAADVGIGVGARGSDAAREAADLVLTDDDLETLL 568
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034633534  863 KAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATE 928
Cdd:cd07539    569 DAVVEGRTMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTRQLLLVNLLTDMFPALALAVE 634
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
156-972 7.63e-87

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 301.96  E-value: 7.63e-87
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  156 AILLSVicVVLVTAFNDWSKEKQfrglQSRIEQE------QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd02608     72 GIVLAA--VVIVTGCFSYYQEAK----SSKIMDSfknmvpQQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRII 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  230 QGNDLKIDESSLTGESDQVRKSVD---KDPM------LLSgTHVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkd 300
Cdd:cd02608    146 SAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS-TNCVEGTARGIVINTGDRTVMGRIATL------------ 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  301 kkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdASQskakqqdgaaamemqplksaeggdaddrkkasmhk 380
Cdd:cd02608    213 ------------------------------------------ASG----------------------------------- 215
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  381 keksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDtfVVNKKPWLPECtpvyvqyfvkFFIIGVtvlVVA-VPEGL 459
Cdd:cd02608    216 -----LEVGKTPIAREIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLIGI---IVAnVPEGL 275
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  460 PLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQA-YVGDVHYKEIPDPSSINTKT---- 534
Cdd:cd02608    276 LATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMwFDNQIHEADTTEDQSGASFDkssa 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  535 --MELLINAIAINSAyttKILPPEKEGALPRQV--GNKTECGLLGFVLDLKQDYEPVRSQMPeeKLYKVyTFNSVRK--- 607
Cdd:cd02608    356 twLALSRIAGLCNRA---EFKAGQENVPILKRDvnGDASESALLKCIELSCGSVMEMRERNP--KVAEI-PFNSTNKyql 429
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  608 SMSTVIKLPDESFRMYSKGASEIVLKKCCKIL-NGAGEPrvfrprdRDEMVKKVIEP--MACDGL--RTI--CVAY---R 677
Cdd:cd02608    430 SIHENEDPGDPRYLLVMKGAPERILDRCSTILiNGKEQP-------LDEEMKEAFQNayLELGGLgeRVLgfCHLYlpdD 502
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  678 DFPSSPEPDWDNENDILNELtciCVVGIE---DPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedf 754
Cdd:cd02608    503 KFPEGFKFDTDEVNFPTENL---CFVGLMsmiDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGII------ 573
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  755 lclegkefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKAD 832
Cdd:cd02608    574 --------------------------------VFARTSPQQKLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKAD 614
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  833 VGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNvVAVIVAFTgACITQDSPLK--AVQM 910
Cdd:cd02608    615 IGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN-IPEITPFL-IFIIANIPLPlgTITI 692
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034633534  911 LWVNLIMDTFASLALATEPPTETLLLRKPygRNkPLISRTMMKNILGHAVYQLALI-----FTLLFV 972
Cdd:cd02608    693 LCIDLGTDMVPAISLAYEKAESDIMKRQP--RN-PKTDKLVNERLISMAYGQIGMIqalagFFTYFV 756
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
71-962 6.43e-86

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 293.19  E-value: 6.43e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLsfyhppgegnegcataqggaedeGEAEag 150
Cdd:cd07538      3 TEAEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVL-----------------------GDPR-- 57
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  151 wiEGAAILLSVICVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:cd07538     58 --EGLILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLE 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  231 GNDLKIDESSLTGESDQVRKSVD----------KDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeeekkd 300
Cdd:cd07538    134 NDDLGVDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI--------------- 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  301 kkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdGAAAMEMQplksaeggdaddrkkasmhk 380
Cdd:cd07538    199 ----------------------------------------------------GKSLAEMD-------------------- 206
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  381 KEKSVLQGKLTKLAVQIGKAGLVMSAITVIIlvlyftvdtFVVNKKPWLpectpvyvqyfvKFFIIGVTVLVVAVPEGLP 460
Cdd:cd07538    207 DEPTPLQKQTGRLVKLCALAALVFCALIVAV---------YGVTRGDWI------------QAILAGITLAMAMIPEEFP 265
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  461 LAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVgdvhykeipdpssintktmellin 540
Cdd:cd07538    266 VILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGTLTKNQMEVVELTS------------------------ 321
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  541 aiainsayttkilppekegalprqvgnktecgllgfvldlkqdyePVRSqmpeeklykvYTFNSVRKSMSTVIKLPDESF 620
Cdd:cd07538    322 ---------------------------------------------LVRE----------YPLRPELRMMGQVWKRPEGAF 346
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  621 rMYSKGASEIVLKKCckilngageprVFRPRDRDEMVKKVIEpMACDGLRTICVAyrdfpsSPEPDWDNENDILNELTCI 700
Cdd:cd07538    347 -AAAKGSPEAIIRLC-----------RLNPDEKAAIEDAVSE-MAGEGLRVLAVA------ACRIDESFLPDDLEDAVFI 407
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  701 CV--VGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIH-----PGEDFLCLEGKEFNRRIRNekgei 773
Cdd:cd07538    408 FVglIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATAKAIAKQIGLDNtdnviTGQELDAMSDEELAEKVRD----- 482
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  774 eqeridkiwpkLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIIL 853
Cdd:cd07538    483 -----------VNIFARVVPEQKLRIVQAF-----KANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVL 546
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  854 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTET 933
Cdd:cd07538    547 LDDNFSSIVSTIRLGRRIYDNLKKAITYVFAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERD 626
                          890       900
                   ....*....|....*....|....*....
gi 1034633534  934 LLLRKPYGRNKPLISrtmmKNILGHAVYQ 962
Cdd:cd07538    627 IMRRPPRPPDEPLFG----PRLVIKAILQ 651
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
190-965 4.49e-82

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 290.15  E-value: 4.49e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVD---KDPM-----LLSG 261
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  262 THVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnv 341
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL----------------------------------------------------- 247
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  342 dasqskakqqdgaaamemqplksAEGgdaddrkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDtf 421
Cdd:TIGR01106  248 -----------------------ASG------------------LENGKTPIAIEIEHFIHIITGVAVFLGVSFFILS-- 284
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  422 VVNKKPWLPECtpvyvqyfvkFFIIGVtvLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKT 501
Cdd:TIGR01106  285 LILGYTWLEAV----------IFLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKT 352
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  502 GTLTTNRMTVV------QAYVGDV---HYKEIPDPSSINTKTMELLinAIAINSAyttkILPPEKEGA--LPRQV-GNKT 569
Cdd:TIGR01106  353 GTLTQNRMTVAhmwfdnQIHEADTtedQSGVSFDKSSATWLALSRI--AGLCNRA----VFKAGQENVpiLKRAVaGDAS 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  570 ECGLLGFVLDLKQDYEPVRSQMPeeKLYKVyTFNSVRKSMSTVIKLPDES---FRMYSKGASEIVLKKCCKIL-NGAGEP 645
Cdd:TIGR01106  427 ESALLKCIELCLGSVMEMRERNP--KVVEI-PFNSTNKYQLSIHENEDPRdprHLLVMKGAPERILERCSSILiHGKEQP 503
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  646 RvfrprdrDEMVKKVIEP--MACDGL--RTI--CVAY---RDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEA 716
Cdd:TIGR01106  504 L-------DEELKEAFQNayLELGGLgeRVLgfCHLYlpdEQFPEGFQFDTDDVNFPTDNLCFVGLISMIDPPRAAVPDA 576
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  717 IRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG----EDF---LCLEGKEFNRRIRN-------EKGEIEQERIDKIw 782
Cdd:TIGR01106  577 VGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGnetvEDIaarLNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI- 655
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  783 pkLR-----VLARSSPTDKHTLVKGIidsthteQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTD 855
Cdd:TIGR01106  656 --LKyhteiVFARTSPQQKLIIVEGC-------QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLD 726
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  856 DNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV--VAVIVAFTGACITQdsPLKAVQMLWVNLIMDTFASLALATEPPTET 933
Cdd:TIGR01106  727 DNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIpeITPFLIFIIANIPL--PLGTITILCIDLGTDMVPAISLAYEKAESD 804
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|...
gi 1034633534  934 LLLRKPYGR------NKPLISRT-----MMKNILGHAVYQLAL 965
Cdd:TIGR01106  805 IMKRQPRNPktdklvNERLISMAygqigMIQALGGFFTYFVIL 847
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
151-983 1.06e-78

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 281.52  E-value: 1.06e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  151 WIEGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKftVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQ 230
Cdd:TIGR01523   81 WIEGGVISAIIALNILIGFIQEYKAEKTMDSLKNLASPMAH--VIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIE 158
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  231 GNDLKIDESSLTGESDQVRKSV-------------DKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGIIftllgaggeeee 297
Cdd:TIGR01523  159 TKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFSSSAVTKGRAKGICIATALNSEIGAI------------ 226
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  298 kkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqSKAKQQDGAAamemqpLKSAEGGDADDRKKAS 377
Cdd:TIGR01523  227 ------------------------------------------------AAGLQGDGGL------FQRPEKDDPNKRRKLN 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  378 MH--KKEKSV------------LQGKLTKLAVqigkaglVMSAITVIILVLYFTVDTFVVNKKpwlpectpvyvqyfvkF 443
Cdd:TIGR01523  253 KWilKVTKKVtgaflglnvgtpLHRKLSKLAV-------ILFCIAIIFAIIVMAAHKFDVDKE----------------V 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  444 FIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKE 523
Cdd:TIGR01523  310 AIYAICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTIS 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  524 I---PDPSSINTKTMELLIN----AIAINSAYTTKILPPEK----EGALPRQV--------------------------- 565
Cdd:TIGR01523  390 IdnsDDAFNPNEGNVSGIPRfspyEYSHNEAADQDILKEFKdelkEIDLPEDIdmdlfiklletaalaniatvfkddatd 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  566 -----GNKTECGLlgFVLDLKQDYePVRSQMPEEKLYKV-------------------------YTFNSVRKSMSTVIK- 614
Cdd:TIGR01523  470 cwkahGDPTEIAI--HVFAKKFDL-PHNALTGEEDLLKSnendqsslsqhnekpgsaqfefiaeFPFDSEIKRMASIYEd 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  615 LPDESFRMYSKGASEIVLKkCCKILNGAGEPRVFRPRDRD-EMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNENDI 693
Cdd:TIGR01523  547 NHGETYNIYAKGAFERIIE-CCSSSNGKDGVKISPLEDCDrELIIANMESLAAEGLRVLAFASKSFDKADNNDDQLKNET 625
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  694 LN------ELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII--------HPGEDFLCLEG 759
Cdd:TIGR01523  626 LNrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfihdrDEIMDSMVMTG 705
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  760 KEFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKhtlVKgIIDSTHtEQRQVVAVTGDGTNDGPALKKADVGFAMGI 839
Cdd:TIGR01523  706 SQFD--------ALSDEEVDDLKALCLVIARCAPQTK---VK-MIEALH-RRKAFCAMTGDGVNDSPSLKMANVGIAMGI 772
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  840 AGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQMLWVN 914
Cdd:TIGR01523  773 NGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVEILWCI 852
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034633534  915 LIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYqLALIFTLLFVGeKMFQIDSGR 983
Cdd:TIGR01523  853 MITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFF-LGGSCLASFTG-ILYGFGSGN 919
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
152-933 7.99e-68

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 244.44  E-value: 7.99e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  152 IEGAAIL---------LSVICVVLVT-AFNDWSKEKQFRGLQSRIEQ--EQKFTVVRAGQVVQIPVAEIVVGDIAQVKYG 219
Cdd:cd02076     42 LEAAAILaaalgdwvdFAIILLLLLInAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIG 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  220 DLLPADGLFIQGNDLKIDESSLTGESDQVRKSvdKDPMLLSGTHVMEGSGRMLVTAVGVNSQTGiiftllgaggeeeekk 299
Cdd:cd02076    122 DIVPADARLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFG---------------- 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  300 dkkgvkkgdglqlpaadgaaasnaadsANASLVNgkmqdgnvdasqskakqqdgaaamemqplkSAEGgdaddrkkasmh 379
Cdd:cd02076    184 ---------------------------KTAALVA------------------------------SAEE------------ 194
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  380 kkeksvlQGKLTKLAVQIGKAGLVMSAITV--IILVLYFTVDTFVvnkkpwlpectpvyvqYFVKFFIIgvtVLVVAVPE 457
Cdd:cd02076    195 -------QGHLQKVLNKIGNFLILLALILVliIVIVALYRHDPFL----------------EILQFVLV---LLIASIPV 248
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  458 GLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEipdpssintktmEL 537
Cdd:cd02076    249 AMPAVLTVTMAVGALELAKKKAIVSRLSAIEELAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKD------------EL 316
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  538 LINAiainsAYTTKilpPEKEGALPRQVgnktecglLGFVldlkQDYEPVRSQMPEEKLYKvytFNSVRK-SMSTVIKLP 616
Cdd:cd02076    317 LLLA-----ALASD---TENPDAIDTAI--------LNAL----DDYKPDLAGYKQLKFTP---FDPVDKrTEATVEDPD 373
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  617 DESFRmYSKGASEIVLKKCCKilngageprvfrPRDRDEMVKKVIEPMACDGLRTICVAYRDfpssPEPDWDnendILNE 696
Cdd:cd02076    374 GERFK-VTKGAPQVILELVGN------------DEAIRQAVEEKIDELASRGYRSLGVARKE----DGGRWE----LLGL 432
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  697 LTCIcvvgieDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGI---IHPGEDFLCLEGKefnrriRNEKGEI 773
Cdd:cd02076    433 LPLF------DPPRPDSKATIARAKELGVRVKMITGDQLAIAKETARQLGMgtnILSAERLKLGGGG------GGMPGSE 500
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  774 EQERIDKiwpkLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIL 853
Cdd:cd02076    501 LIEFIED----ADGFAEVFPEHKYRIVEALQQRGH-----LVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVL 570
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  854 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVnVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATE--PPT 931
Cdd:cd02076    571 TAPGLSVIIDAIKTSRQIFQRMKSYVIYRIAE-TLRILVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYDnvPPS 649

                   ..
gi 1034633534  932 ET 933
Cdd:cd02076    650 PR 651
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
71-927 4.37e-64

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 233.29  E-value: 4.37e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   71 TAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGEGNegcataqggaedegeaeag 150
Cdd:cd02077      3 TNEEAEERLEKYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD------------------- 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  151 wIEGAAILLS-VICVVLVTAFNDWSKEKQFRGLQSRIEQeqKFTVVRAGQVVQ-IPVAEIVVGDIAQVKYGDLLPADGLF 228
Cdd:cd02077     64 -LVGALIILLmVLISGLLDFIQEIRSLKAAEKLKKMVKN--TATVIRDGSKYMeIPIDELVPGDIVYLSAGDMIPADVRI 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  229 IQGNDLKIDESSLTGESDQVRKSV-----------DKDPMLLSGTHVMEGSGRMLVTAVGVNsqtgiifTLLGaggeeee 297
Cdd:cd02077    141 IQSKDLFVSQSSLTGESEPVEKHAtakktkdesilELENICFMGTNVVSGSALAVVIATGND-------TYFG------- 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  298 kkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdgaaamemqplkSAEGGDADDRKKAS 377
Cdd:cd02077    207 ------------------------------------------------------------------SIAKSITEKRPETS 220
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  378 MHKKEKSVlqgklTKLavqigkaglvmsaITVIILVLYFTVdtFVVN---KKPWLpectpvyvqyfvKFFIIGVTVLVVA 454
Cdd:cd02077    221 FDKGINKV-----SKL-------------LIRFMLVMVPVV--FLINgltKGDWL------------EALLFALAVAVGL 268
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  455 VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYvgdvhykeipdpsSINTKT 534
Cdd:cd02077    269 TPEMLPMIVTSNLAKGAVRMSKRKVIVKNLNAIQNFGAMDILCTDKTGTLTQDKIVLERHL-------------DVNGKE 335
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  535 MELLINAIAINSAYTTKILPPeKEGALPRQVGNKTECGLlgfvldlKQDYEPVrSQMPeeklykvytFNSVRKSMSTVIK 614
Cdd:cd02077    336 SERVLRLAYLNSYFQTGLKNL-LDKAIIDHAEEANANGL-------IQDYTKI-DEIP---------FDFERRRMSVVVK 397
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  615 LPDESFRMYSKGASEIVLKKCCKI-LNGAGEPRVFRPRdrdEMVKKVIEPMACDGLRTICVAYRDFPSspePDWDNENDI 693
Cdd:cd02077    398 DNDGKHLLITKGAVEEILNVCTHVeVNGEVVPLTDTLR---EKILAQVEELNREGLRVLAIAYKKLPA---PEGEYSVKD 471
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  694 LNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihPGEDflCLEGKEFNrrirnekgEI 773
Cdd:cd02077    472 EKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAICKQVGL--DINR--VLTGSEIE--------AL 539
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  774 EQERIDKIWPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIL 853
Cdd:cd02077    540 SDEELAKIVEETNIFAKLSPLQKARIIQAL-----KKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIIL 613
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034633534  854 TDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVN---VVAVIVAftgACITQDSPLKAVQMLWVNLIMDtFASLALAT 927
Cdd:cd02077    614 LEKDLMVLEEGVIEGRKTFGNILKYIKMTASSNfgnVFSVLVA---SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPF 686
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
191-932 1.24e-61

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 223.70  E-value: 1.24e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  191 KFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGR 270
Cdd:cd02609     93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPKKAGDK--LLSGSFVVSGAAY 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  271 MLVTAVGVNSQtgiiftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdASQ--SKA 348
Cdd:cd02609    171 ARVTAVGAESY-------------------------------------------------------------AAKltLEA 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  349 KQqdgaaamemqplksaeggdaddrkkasmHKKEKSVLQGKLTKLAVqigkaglVMSAITVIILVLYFtVDTFVVNKKPW 428
Cdd:cd02609    190 KK----------------------------HKLINSELLNSINKILK-------FTSFIIIPLGLLLF-VEALFRRGGGW 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  429 lpectpvyvqyfvKFFIIG-VTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTN 507
Cdd:cd02609    234 -------------RQAVVStVAALLGMIPEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEG 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  508 RMTVVQAYVGDVHYKEIpdpssiNTKTMELLINAIAINSAyTTKILppekegalprqvgnktecgLLGFVLDLKQdyePV 587
Cdd:cd02609    301 KMKVERVEPLDEANEAE------AAAALAAFVAASEDNNA-TMQAI-------------------RAAFFGNNRF---EV 351
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  588 RSQMPeeklykvytFNSVRKsMSTVIKLPDESFRMyskGASEIVLkkcckilngageprvfrpRDRDEMVKKVIEPMACD 667
Cdd:cd02609    352 TSIIP---------FSSARK-WSAVEFRDGGTWVL---GAPEVLL------------------GDLPSEVLSRVNELAAQ 400
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  668 GLRTICVAYrdfpSSPEPDWDNendILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGi 747
Cdd:cd02609    401 GYRVLLLAR----SAGALTHEQ---LPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG- 472
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  748 ihpgedflcLEGKEFNRRIRNEKGEIEQERIDKiwpKLRVLARSSPTDKHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPA 827
Cdd:cd02609    473 ---------LEGAESYIDASTLTTDEELAEAVE---NYTVFGRVTPEQKRQLVQALQALGHT-----VAMTGDGVNDVLA 535
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  828 LKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKA 907
Cdd:cd02609    536 LKEADCSIAMA-SGSDATRQVAQVVLLDSDFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLP 614
                          730       740
                   ....*....|....*....|....*
gi 1034633534  908 VQMLWVNLIMDTFASLALATEPPTE 932
Cdd:cd02609    615 IQITLISLFTIGIPSFFLALEPNKR 639
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
193-896 7.65e-50

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 189.58  E-value: 7.65e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRML 272
Cdd:COG2217    216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DE-VFAGTINLDGSLRVR 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  273 VTAVGVNSQ-TGIIftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaSLVngkmqdgnVDASQSKAKQQ 351
Cdd:COG2217    293 VTKVGSDTTlARII--------------------------------------------RLV--------EEAQSSKAPIQ 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  352 dgaaamemqplksaeggdaddrkkasmhkkeksvlqgkltKLAVQIgkaglvmSAI-TVIILVLyfTVDTFVVnkkpWLp 430
Cdd:COG2217    321 ----------------------------------------RLADRI-------ARYfVPAVLAI--AALTFLV----WL- 346
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  431 ectpVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMT 510
Cdd:COG2217    347 ----LFGGDFSTALYRAVAVLVIACPCALGLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPE 422
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  511 VVqayvgDVHYKEIPDPSSINT--KTMELLIN---AIAINSAYTTKILPPEKegalPRQVGNKTECGLLGFVldlkqdye 585
Cdd:COG2217    423 VT-----DVVPLDGLDEDELLAlaAALEQGSEhplARAIVAAAKERGLELPE----VEDFEAIPGKGVEATV-------- 485
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  586 pvrsqmpEEKLYKVytfnsvrksmstviklpdesfrmyskgaseivlkkcckilngaGEPRVFRPR--DRDEMVKKVIEP 663
Cdd:COG2217    486 -------DGKRVLV-------------------------------------------GSPRLLEEEgiDLPEALEERAEE 515
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  664 MACDGLRTICVAyrdfpsspepdWDNEndilneltCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAI 743
Cdd:COG2217    516 LEAEGKTVVYVA-----------VDGR--------LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVAR 576
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  744 KCGIIHpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIdsthtEQRQVVAVTGDGTN 823
Cdd:COG2217    577 ELGIDE-------------------------------------VRAEVLPEDKAAAVRELQ-----AQGKKVAMVGDGIN 614
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034633534  824 DGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 896
Cdd:COG2217    615 DAPALAAADVGIAMG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLAAGG 686
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
903-1081 2.72e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 172.81  E-value: 2.72e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  903 SPLKAVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLLFVGEKMFQIDSG 982
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  983 RNAplhsppsehYTIIFNTFVMMQLFNEINARKIHGERNVFdGIFRNPIFCTIVLGTFAIQIVIVQ--FGGKPFSCSPLQ 1060
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 1034633534 1061 LDQWMWCIFIGLGELVWGQVI 1081
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
172-896 6.18e-46

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 174.74  E-value: 6.18e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  172 DWSKEKQFRGLQSRIE-QEQKFTVVRA-GQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVR 249
Cdd:TIGR01525   36 ERAKSRASDALSALLAlAPSTARVLQGdGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  250 KSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsana 329
Cdd:TIGR01525  115 KKEGDE--VFAGTINGDGSLTIRVTKLGEDSTLAQIVELV---------------------------------------- 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  330 slvngkmqdgnVDASQSKAKQQDGAAAMEmqplksaeggdaddrkkasmhkkeksvlqGKLTKLAVqigkaglvmsAITV 409
Cdd:TIGR01525  153 -----------EEAQSSKAPIQRLADRIA-----------------------------SYYVPAVL----------AIAL 182
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  410 IILVLYFTVdtfvvnkKPWLPECtpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACET 489
Cdd:TIGR01525  183 LTFVVWLAL-------GALWREA-----------LYRALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEK 244
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  490 MGNATAICSDKTGTLTTNRMTVVQAYV-GDVHYKEIPDPSSintkTMELLIN---AIAINSAYTTKILPPekegaLPRQV 565
Cdd:TIGR01525  245 LAKVKTVVFDKTGTLTTGKPTVVDIEPlDDASEEELLALAA----ALEQSSShplARAIVRYAKERGLEL-----PPEDV 315
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  566 GNKTECGLLGFVldlkQDYEPVRSQMPEEklykvytfnsvrksmstviklpdesfrMYSKGASEIVLKKCCKILNGAGEp 645
Cdd:TIGR01525  316 EEVPGKGVEATV----DGGREVRIGNPRF---------------------------LGNRELAIEPISASPDLLNEGES- 363
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  646 rvfrprdrdemvkkviepmacdGLRTICVAYRDfpsspepdwdnendilNELtcICVVGIEDPVRPEVPEAIRKCQRAG- 724
Cdd:TIGR01525  364 ----------------------QGKTVVFVAVD----------------GEL--LGVIALRDQLRPEAKEAIAALKRAGg 403
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  725 ITVRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeiEQEridkiwpklrVLARSSPTDKHTLVKGIi 804
Cdd:TIGR01525  404 IKLVMLTGDNRSAAEAVAAELGI--------------------------DDE----------VHAELLPEDKLAIVKKL- 446
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  805 dsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLT 884
Cdd:TIGR01525  447 ----QEEGGPVAMVGDGINDAPALAAADVGIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALG 521
                          730
                   ....*....|..
gi 1034633534  885 VNVVAVIVAFTG 896
Cdd:TIGR01525  522 YNLVAIPLAAGG 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
193-865 3.86e-43

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 168.04  E-value: 3.86e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSVDkDPmLLSGThvMEGSGRML 272
Cdd:cd02094    142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DK-VIGGT--INGNGSLL 216
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  273 VTAVGVNSQT---GIIftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaSLVNgkmqdgnvDASQSKAK 349
Cdd:cd02094    217 VRATRVGADTtlaQII--------------------------------------------RLVE--------EAQGSKAP 244
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  350 QQdgaaamemqplksaeggdaddrkkasmhkkeksvlqgkltKLAVQIgkaglvmSAITV-IILVLyfTVDTFVVnkkpW 428
Cdd:cd02094    245 IQ----------------------------------------RLADRV-------SGVFVpVVIAI--AILTFLV----W 271
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  429 L---PECTPVYVqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 505
Cdd:cd02094    272 LllgPEPALTFA------LVAAVAVLVIACPCALGLATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLT 345
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  506 TNRMTVVqayvgDVHykeiPDPSSINTKTMEL-----------LINAIaINSAYTTKILPPEKEG--ALPrqvGnkteCG 572
Cdd:cd02094    346 EGKPEVT-----DVV----PLPGDDEDELLRLaasleqgsehpLAKAI-VAAAKEKGLELPEVEDfeAIP---G----KG 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  573 LLGFVldlkqdyepvrsqmpEEKLYKVytfnsvrksmstviklpdesfrmyskGASEIVLKKCCKILNGAGEprvfrprd 652
Cdd:cd02094    409 VRGTV---------------DGRRVLV--------------------------GNRRLMEENGIDLSALEAE-------- 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  653 rdemvkkvIEPMACDGLRTICVAYrdfpsspepdwDNEndilneltCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTG 732
Cdd:cd02094    440 --------ALALEEEGKTVVLVAV-----------DGE--------LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTG 492
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  733 DNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriDKiwpklrVLARSSPTDKHTLVKGIidsthTEQR 812
Cdd:cd02094    493 DNRRTARAIAKELGI-------------------------------DE------VIAEVLPEDKAEKVKKL-----QAQG 530
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1034633534  813 QVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAV 865
Cdd:cd02094    531 KKVAMVGDGINDAPALAQADVGIAIG-SGTDVAIESADIVLMRGDLRGVVTAI 582
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
172-896 5.58e-43

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 167.01  E-value: 5.58e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  172 DWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd02079    106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  251 SVDkDPmLLSGTHVMEGSGRMLVTAVGVNSQ-TGIIftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsana 329
Cdd:cd02079    185 GAG-DT-VFAGTINLNGPLTIEVTKTGEDTTlAKII-------------------------------------------- 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  330 slvngKMQDgnvDASQSKAKqqdgaaamemqplksaeggdaddrkkasmhkkeksvLQGKLTKLAVQIGKAGLVMSAITV 409
Cdd:cd02079    219 -----RLVE---EAQSSKPP------------------------------------LQRLADRFARYFTPAVLVLAALVF 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  410 IIlvlyftvdtfvvnkkpwlpecTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACET 489
Cdd:cd02079    255 LF---------------------WPLVGGPPSLALYRALAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLET 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  490 MGNATAICSDKTGTLTTNRMTV--VQAYVGDVHYKEIPDPSSINTKTMELLinAIAINSAYTTKILPPEKEGalprQVGN 567
Cdd:cd02079    314 LAKVDTVAFDKTGTLTEGKPEVteIEPLEGFSEDELLALAAALEQHSEHPL--ARAIVEAAEEKGLPPLEVE----DVEE 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  568 KTECGLLGFVLDlkqdyepvrsqmpeeklykvytfnsvrksmstviklpdesfRMYSKGASEIVlkkcckilngageprv 647
Cdd:cd02079    388 IPGKGISGEVDG-----------------------------------------REVLIGSLSFA---------------- 410
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  648 frprdRDEMVKKVIEPMACDGLRTICVAYRDFpsspepdwdnendilnelTCICVVGIEDPVRPEVPEAIRKCQRAGITV 727
Cdd:cd02079    411 -----EEEGLVEAADALSDAGKTSAVYVGRDG------------------KLVGLFALEDQLRPEAKEVIAELKSGGIKV 467
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  728 RMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeridkiwpkLRVLARSSPTDKHTLVKGIidst 807
Cdd:cd02079    468 VMLTGDNEAAAQAVAKELGI-------------------------------------DEVHAGLLPEDKLAIVKAL---- 506
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  808 hTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNV 887
Cdd:cd02079    507 -QAEGGPVAMVGDGINDAPALAQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNA 584

                   ....*....
gi 1034633534  888 VAVIVAFTG 896
Cdd:cd02079    585 IALPLAALG 593
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
151-896 3.10e-41

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 160.57  E-value: 3.10e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  151 WIEGAAILLSVIcvvLVTAFNDWSKEKQFRGLQSRIEQE-QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:TIGR01512   18 YLEGALLLLLFS---IGETLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgvkkgdg 309
Cdd:TIGR01512   95 SGTSS-VDESALTGESVPVEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNLV-------------------- 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  310 lqlpaadgaaasnaadsanaslvngkmqdgnVDASQSKAKqqdgaaamemqplksaeggdaddrkkasmhkkeksvLQGK 389
Cdd:TIGR01512  152 -------------------------------EEAQSRKAP------------------------------------TQRF 164
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  390 LTKLAVQIGKAGLVMSAITVIIlvlyftvdtfvvnkkPWLPECTPvyvqyFVKFFIIGVTVLVVAVPEGLPLAVTISLAY 469
Cdd:TIGR01512  165 IDRFARYYTPAVLAIALAAALV---------------PPLLGAGP-----FLEWIYRALVLLVVASPCALVISAPAAYLS 224
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  470 SVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVqayvgDVHYKEIPDPSSINT--KTMELL---INAIAI 544
Cdd:TIGR01512  225 AISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVT-----DVHPADGHSESEVLRlaAAAEQGsthPLARAI 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  545 NSAYTTKILPPEkegalPRQVGNKTECGLLGFVldlkqdyepvrsqmpeeklykvytfnsvrksmstviklpdesfrmys 624
Cdd:TIGR01512  300 VDYARARELAPP-----VEDVEEVPGEGVRAVV----------------------------------------------- 327
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  625 kgaseivlkkcckilnGAGEPRVFRPRDRDEMVKKVIEPMaCDGLRTICVAYRDFpsspepdwdnendilnelTCICVVG 704
Cdd:TIGR01512  328 ----------------DGGEVRIGNPRSLSEAVGASIAVP-ESAGKTIVLVARDG------------------TLLGYIA 372
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  705 IEDPVRPEVPEAIRKCQRAGI-TVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwp 783
Cdd:TIGR01512  373 LSDELRPDAAEAIAELKALGIkRLVMLTGDRRAVAEAVARELGID----------------------------------- 417
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  784 klRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 863
Cdd:TIGR01512  418 --EVHAELLPEDKLEIVKELREKAG-----PVAMVGDGINDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQ 490
                          730       740       750
                   ....*....|....*....|....*....|...
gi 1034633534  864 AVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 896
Cdd:TIGR01512  491 AIRLARRTRRIIKQNVVIALGIILVLILLALFG 523
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
194-893 2.33e-40

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 158.21  E-value: 2.33e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDkDPmLLSGTHVMEGSGRMLV 273
Cdd:TIGR01511   96 LTKDGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DP-VIAGTVNGTGSLVVRA 172
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  274 TAVGVNSQTGIIFTLLGaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvDASQSKAKqqdg 353
Cdd:TIGR01511  173 TATGEDTTLAQIVRLVR---------------------------------------------------QAQQSKAP---- 197
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  354 aaameMQPLksaeggdADdrkkasmhkkeksvlqgKLTKLavqigkagLVMSAITVIILvlyftvdTFVVnkkpWLpect 433
Cdd:TIGR01511  198 -----IQRL-------AD-----------------KVAGY--------FVPVVIAIALI-------TFVI----WL---- 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  434 pvyvqyfvkF-FIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV 512
Cdd:TIGR01511  226 ---------FaLEFAVTVLIIACPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVT 296
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  513 qayvgDVHykeiPDPSSINTKTMELlINAIAINS---------AYTtkilppEKEGALPRQVGN-KTECGLlgfvlDLKQ 582
Cdd:TIGR01511  297 -----DVH----VFGDRDRTELLAL-AAALEAGSehplakaivSYA------KEKGITLVTVSDfKAIPGI-----GVEG 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  583 DYEPVRSQMPEEKLYKVYTfnsvrksmstvIKLPDESfrmysKGASEIVLkkcckilngageprvfrprdrdemvkkvie 662
Cdd:TIGR01511  356 TVEGTKIQLGNEKLLGENA-----------IKIDGKA-----GQGSTVVL------------------------------ 389
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  663 pmacdglrticvayrdfpsspepdwdneNDILNELTCIcvVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIA 742
Cdd:TIGR01511  390 ----------------------------VAVNGELAGV--FALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVA 439
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  743 IKCGIihpgedflclegkefnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGT 822
Cdd:TIGR01511  440 KELGI--------------------------------------DVRAEVLPDDKAALIKKL-----QEKGPVVAMVGDGI 476
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034633534  823 NDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 893
Cdd:TIGR01511  477 NDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDVATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
52-893 6.26e-39

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 157.54  E-value: 6.26e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534   52 DTEAICRRLKTSPvEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQD-----VTLiileiaaiisLGLSFYhp 126
Cdd:PRK10517    53 PEEELWKTFDTHP-EGL--NEAEVESAREQHGENELPAQKPLPWWVHLWVCYRNpfnilLTI----------LGAISY-- 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  127 pgegnegcATaqggaEDEGeaeagwiegAAILLSVIcVVLVTAFNDWSKEKQFRG---LQSRIEQeqKFTVVRAGQV--- 200
Cdd:PRK10517   118 --------AT-----EDLF---------AAGVIALM-VAISTLLNFIQEARSTKAadaLKAMVSN--TATVLRVINDkge 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  201 ---VQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRK-----------SVDKDPMLLSGTHVME 266
Cdd:PRK10517   173 ngwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECDTLCFMGTNVVS 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  267 GSGRMLVTAVGVNSQTGIIFTLLGAggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmQDGNVDASQS 346
Cdd:PRK10517   253 GTAQAVVIATGANTWFGQLAGRVSE---------------------------------------------QDSEPNAFQQ 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  347 KAKqqdgaaamemqplksaeggdaddrkKASMhkkeksvlqgKLTKLAvqigkagLVMSAitVIILVLYFTvdtfvvnKK 426
Cdd:PRK10517   288 GIS-------------------------RVSW----------LLIRFM-------LVMAP--VVLLINGYT-------KG 316
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  427 PWlpectpvyvqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT 506
Cdd:PRK10517   317 DW------------WEAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQ 384
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  507 NRMtVVQAYVgDVHYKeipdpssintKTMELLINAIaINSAYTTKIlppekEGALPRQVgnkTECGLLGFVLDLKQDYEP 586
Cdd:PRK10517   385 DKI-VLENHT-DISGK----------TSERVLHSAW-LNSHYQTGL-----KNLLDTAV---LEGVDEESARSLASRWQK 443
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  587 VrSQMPeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKI-LNGAGEPRVfrpRDRDEMVKKVIEPMA 665
Cdd:PRK10517   444 I-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQVrHNGEIVPLD---DIMLRRIKRVTDTLN 510
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  666 CDGLRTICVAYRDFPSSPEpDWD--NENDilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAI 743
Cdd:PRK10517   511 RQGLRVVAVATKYLPAREG-DYQraDESD----LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCH 585
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  744 KCGIIHPGedflCLEGkefnrrirnekGEIEQ---ERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTHteqrqVVAVTGD 820
Cdd:PRK10517   586 EVGLDAGE----VLIG-----------SDIETlsdDELANLAERTTLFARLTPMHKERIVTLLKREGH-----VVGFMGD 645
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034633534  821 GTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 893
Cdd:PRK10517   646 GINDAPALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
407-967 2.29e-34

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 142.69  E-value: 2.29e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  407 ITVIILVLYFTVDTFVVNKK-----PWL--PECTPVYVQYFVKF--FIIgvtVLVVAVPegLPLAVTISLAYSV------ 471
Cdd:cd02073    253 CILIVMCLISAIGKGIWLSKhgrdlWYLlpKEERSPALEFFFDFltFII---LYNNLIP--ISLYVTIEVVKFLqsffin 327
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  472 --KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipdpssintktmeLLINAIAI- 544
Cdd:cd02073    328 wdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDY---------------GFFLALALc 392
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  545 NSAYTTKILPPEK---------EGALPRQvgnkteCGLLGFVLdLKQDYEPV-RSQMPEEKLYK---VYTFNSVRKSMST 611
Cdd:cd02073    393 HTVVPEKDDHPGQlvyqasspdEAALVEA------ARDLGFVF-LSRTPDTVtINALGEEEEYEilhILEFNSDRKRMSV 465
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  612 VIKLPDESFRMYSKGASEIVLKKCckilngAGEPRVFRprdrdEMVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNE- 690
Cdd:cd02073    466 IVRDPDGRILLYCKGADSVIFERL------SPSSLELV-----EKTQEHLEDFASEGLRTLCLAYREISEEEYEEWNEKy 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  691 ------------------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPG- 751
Cdd:cd02073    535 deastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLLSEDm 614
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  752 EDF-LCLEGKEFNrrirnekgEIEQERIDKIWPKLRVLA------RSSPTDKHTLVKGIIDSThteqRQVVAVTGDGTND 824
Cdd:cd02073    615 ENLaLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSK----KAVTLAIGDGAND 682
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  825 GPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFSSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV----- 892
Cdd:cd02073    683 VSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFYKNIAFYLTqfwyq 754
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  893 AFTGAciTQDSPLKAVQMLWVNLImdtFASLalatePP----------TETLLLRKP----YGRNKPLIS-RTMMKNILg 957
Cdd:cd02073    755 FFNGF--SGQTLYDSWYLTLYNVL---FTSL-----PPlvigifdqdvSAETLLRYPelykPGQLNELFNwKVFLYWIL- 823
                          650
                   ....*....|
gi 1034633534  958 HAVYQLALIF 967
Cdd:cd02073    824 DGIYQSLIIF 833
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
194-893 2.78e-32

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 134.35  E-value: 2.78e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESdqvrKSVDKDP--MLLSGTHVMEGSGRM 271
Cdd:cd07552    135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEV 209
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  272 LVTAVGVNSQTGIIFTLLGaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvDASQSKAKQQ 351
Cdd:cd07552    210 KVTKTGEDSYLSQVMELVA---------------------------------------------------QAQASKSRAE 238
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  352 DGAaamemqplksaeggdadDRkkasmhkkeksvLQGKLTKLAVQIGkaglvmsAITVIILVLYFTVDTFVvnkkpwlpe 431
Cdd:cd07552    239 NLA-----------------DK------------VAGWLFYIALGVG-------IIAFIIWLILGDLAFAL--------- 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  432 ctpvyvqyfvkffIIGVTVLVVAVPEGL----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTTN 507
Cdd:cd07552    274 -------------ERAVTVLVIACPHALglaiPLVVARSTSIAAKNGL----LIRNREALERARDIDVVLFDKTGTLTEG 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  508 RMTVVQAYV-GDVHYKEIpdpssinTKTMELLIN------AIAINSAYTTKILPPEKegalPRQVGNKTECGLLGFVldl 580
Cdd:cd07552    337 KFGVTDVITfDEYDEDEI-------LSLAAALEAgsehplAQAIVSAAKEKGIRPVE----VENFENIPGVGVEGTV--- 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  581 kqdyepvrsqmpEEKLYKVYTFNSVRKSMstvIKLPDESFRMY-SKGASEIVLkkcckilngageprvfrprdrdemvkk 659
Cdd:cd07552    403 ------------NGKRYQVVSPKYLKELG---LKYDEELVKRLaQQGNTVSFL--------------------------- 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  660 viepmacdglrticvayrdfpsspepdwdnendiLNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTAR 739
Cdd:cd07552    441 ----------------------------------IQDGEVIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQ 486
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  740 AIAIKCGIIhpgedflclegkefnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTG 819
Cdd:cd07552    487 AVAEELGID-------------------------------------EYFAEVLPEDKAKKVK-----ELQAEGKKVAMVG 524
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034633534  820 DGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 893
Cdd:cd07552    525 DGVNDAPALAQADVGIAIG-AGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIPLA 597
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
481-894 5.92e-32

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 135.59  E-value: 5.92e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  481 VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHY-----------------------KEIPDPSSINTKTMEL 537
Cdd:TIGR01652  347 VRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgdgfteikdgirerlgsyvenenSMLVESKGFTFVDPRL 426
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  538 L-------INAIAINSAYTT-----KILP---PEKEGALPRQVGNKTECGL------LGFVLDLKQDY-----EPVRSQM 591
Cdd:TIGR01652  427 VdllktnkPNAKRINEFFLAlalchTVVPefnDDGPEEITYQAASPDEAALvkaardVGFVFFERTPKsisllIEMHGET 506
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  592 PEEKLYKVYTFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKkcckILNGAGeprvfrpRDRDEMVKKVIEPMACDGLRT 671
Cdd:TIGR01652  507 KEYEILNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK----RLSSGG-------NQVNEETKEHLENYASEGLRT 575
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  672 ICVAYRDFPSSPEPDW-----------DNENDILNE--------LTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTG 732
Cdd:TIGR01652  576 LCIAYRELSEEEYEEWneeyneastalTDREEKLDVvaesiekdLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTG 655
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  733 DNINTARAIAIKCGIIHPGEDFL---------CLEGKEFNRRIRNEKGEIEQERIDK---------------IWPKLR-- 786
Cdd:TIGR01652  656 DKVETAINIGYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDEELEke 735
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  787 ----------VLA-RSSPTDKHTLVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIIL 853
Cdd:TIGR01652  736 flqlalkckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMASDFAI 809
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 1034633534  854 TddNFSSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAF 894
Cdd:TIGR01652  810 G--QFRFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQF 849
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
193-952 3.31e-31

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 132.84  E-value: 3.31e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  193 TVVR------AGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQV----------RKSVDKDP 256
Cdd:PRK15122   151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVekydtlgavaGKSADALA 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  257 -----------MLLSGTHVMEGSGRMLVTAVGVNSQTGiiftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaad 325
Cdd:PRK15122   231 ddegslldlpnICFMGTNVVSGTATAVVVATGSRTYFG------------------------------------------ 268
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  326 sanaslvngkmqdgnvdasqSKAKQQDGaaamemqplksaeggdadDRKKASMHKKEKSVlqgklTKLAVqigKAGLVMs 405
Cdd:PRK15122   269 --------------------SLAKSIVG------------------TRAQTAFDRGVNSV-----SWLLI---RFMLVM- 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  406 aITVIILVLYFTvdtfvvnKKPWLPECTpvyvqyfvkfFiigvtVLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVR 482
Cdd:PRK15122   302 -VPVVLLINGFT-------KGDWLEALL----------F-----ALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVK 358
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  483 HLDACETMGNATAICSDKTGTLTTNRMTVVQAYvgDVHYKEipdpssiNTKTMELlinaIAINSAYTTKILPPEKEGALP 562
Cdd:PRK15122   359 RLNAIQNFGAMDVLCTDKTGTLTQDRIILEHHL--DVSGRK-------DERVLQL----AWLNSFHQSGMKNLMDQAVVA 425
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  563 RQVGNKTECGLLGFvldLKQDYEPvrsqmpeeklykvytFNSVRKSMSTVIKLPDESFRMYSKGASEIVLKKCCKILNGa 642
Cdd:PRK15122   426 FAEGNPEIVKPAGY---RKVDELP---------------FDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVRDG- 486
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  643 GEPRVFRPRDRDEMVKKVIEPMAcDGLRTICVAYRDFPSSPEPDW---DNENDILNE--LTCIcvvgieDPVRPEVPEAI 717
Cdd:PRK15122   487 DTVRPLDEARRERLLALAEAYNA-DGFRVLLVATREIPGGESRAQystADERDLVIRgfLTFL------DPPKESAAPAI 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  718 RKCQRAGITVRMVTGDN-INTARaIAIKCGIiHPGEDflcLEGKEFNRRIRNEKGEIEQERIdkiwpklrVLARSSPTDK 796
Cdd:PRK15122   560 AALRENGVAVKVLTGDNpIVTAK-ICREVGL-EPGEP---LLGTEIEAMDDAALAREVEERT--------VFAKLTPLQK 626
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  797 HTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIS 876
Cdd:PRK15122   627 SRVLKALQANGHT-----VGFLGDGINDAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNII 700
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  877 KFLqfQLTV-----NVVAVIVAftGACITQdSPLKAVQMLWVNLIMDtFASLALatepPTETL---LLRKPYGRNKPLIS 948
Cdd:PRK15122   701 KYL--NMTAssnfgNVFSVLVA--SAFIPF-LPMLAIHLLLQNLMYD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIG 770

                   ....
gi 1034633534  949 RTMM 952
Cdd:PRK15122   771 RFML 774
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
450-973 5.53e-31

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 132.49  E-value: 5.53e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  450 VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV--VQAYVGDVHY-KEIPD 526
Cdd:TIGR01657  405 IITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVCCFDKTGTLTEDGLDLrgVQGLSGNQEFlKIVTE 484
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  527 PSSINtktMELLINAIAINSAyTTKIlppekEGALprqVGNKTECGLLGFV-LDLKQDYE---------PVRSQMPEEKL 596
Cdd:TIGR01657  485 DSSLK---PSITHKALATCHS-LTKL-----EGKL---VGDPLDKKMFEATgWTLEEDDEsaeptsilaVVRTDDPPQEL 552
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  597 Y--KVYTFNSVRKSMSTVIKLPDESFRM-YSKGASEIVLKKCCKilngagePRVfrPRDRDEMVKKVIEpmacDGLRTIC 673
Cdd:TIGR01657  553 SiiRRFQFSSALQRMSVIVSTNDERSPDaFVKGAPETIQSLCSP-------ETV--PSDYQEVLKSYTR----EGYRVLA 619
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  674 VAYRDFPSSPepdWD-----NENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGII 748
Cdd:TIGR01657  620 LAYKELPKLT---LQkaqdlSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIV 696
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  749 ------------------------HPGEDF---------------------------LCLEGKEFNRRIRNEKgeieqER 777
Cdd:TIGR01657  697 npsntlilaeaeppesgkpnqikfEVIDSIpfastqveipyplgqdsvedllasryhLAMSGKAFAVLQAHSP-----EL 771
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  778 IDKIWPKLRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAM-----GIAGTDVAKEAS--- 849
Cdd:TIGR01657  772 LLRLLSHTTVFARMAPDQKETLVE-----LLQKLDYTVGMCGDGANDCGALKQADVGISLseaeaSVAAPFTSKLASisc 846
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  850 --DIILTddnfssivkavmwGR-NVYDSISKFlQFQLTVNVVAVIVAFTGACItqDSPLKAVQMLWVNLIMDTFASLALA 926
Cdd:TIGR01657  847 vpNVIRE-------------GRcALVTSFQMF-KYMALYSLIQFYSVSILYLI--GSNLGDGQFLTIDLLLIFPVALLMS 910
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633534  927 TEPPTETLLLRKPYGRnkpLISRTMMKNILGhavyQLALIFTLLFVG 973
Cdd:TIGR01657  911 RNKPLKKLSKERPPSN---LFSVYILTSVLI----QFVLHILSQVYL 950
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
194-896 1.67e-27

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 119.28  E-value: 1.67e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLV 273
Cdd:cd07551    117 IQRDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRV 193
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  274 TAVgvNSQT---GIIftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaSLVNgkmqdgnvDASQSKAKQ 350
Cdd:cd07551    194 TKL--SSDTvfaKIV--------------------------------------------QLVE--------EAQSEKSPT 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  351 QdgaaamemQPLKSAEGGdaddrkkasmhkkeksvlqgkltklavqigKAGLVMSAITVIILVLYFtvdtfvVNKKPWLP 430
Cdd:cd07551    220 Q--------SFIERFERI------------------------------YVKGVLLAVLLLLLLPPF------LLGWTWAD 255
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  431 EctpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMT 510
Cdd:cd07551    256 S------------FYRAMVFLVVASPCALVASTPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPR 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  511 VVqayvgDVHYKEIPDPSSINT--KTMELLIN---AIAINSAYTTKILPPekegALPRQVGNKTECGLLGFVldlkqdye 585
Cdd:cd07551    324 VT-----DVIPAEGVDEEELLQvaAAAESQSEhplAQAIVRYAEERGIPR----LPAIEVEAVTGKGVTATV-------- 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  586 pvrsqmpEEKLYKVytfnsvrksmstviklpdesfrmyskgaseivlkkcckilngaGEPRVFRPRDRDEMVKKVIEPMA 665
Cdd:cd07551    387 -------DGQTYRI-------------------------------------------GKPGFFGEVGIPSEAAALAAELE 416
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  666 CDGLRTICVAYRDfpsspepdwdnendilnelTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKC 745
Cdd:cd07551    417 SEGKTVVYVARDD-------------------QVVGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKEL 477
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  746 GIihpgedflclegkefnrrirnekgeieqeriDKIWPKLRvlarssPTDKhtlVKgIIDSTHTEQRQVvAVTGDGTNDG 825
Cdd:cd07551    478 GI-------------------------------DEVVANLL------PEDK---VA-IIRELQQEYGTV-AMVGDGINDA 515
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034633534  826 PALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 896
Cdd:cd07551    516 PALANADVGIAMG-AGTDVALETADVVLMKDDLSKLPYAIRLSRKMRRIIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
450-972 2.06e-27

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 120.05  E-value: 2.06e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  450 VLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETMGNATAI---CSDKTGTLTTNRMTVVQAYVGDVHYKE 523
Cdd:cd07542    262 IITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRINICGKInlvCFDKTGTLTEDGLDLWGVRPVSGNNFG 335
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  524 IPDPSSINTKTMELLINAIAINSAYTTKILppekegalpRQVGNKtecgLLGFVLDLKQ------DYEPVRSqmpeekly 597
Cdd:cd07542    336 DLEVFSLDLDLDSSLPNGPLLRAMATCHSL---------TLIDGE----LVGDPLDLKMfeftgwSLEILRQ-------- 394
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  598 kvYTFNSVRKSMSTVIKLP-DESFRMYSKGASEIVLKKCckilngagEPRVFrPRDRDEMVKKviepMACDGLRTICVAY 676
Cdd:cd07542    395 --FPFSSALQRMSVIVKTPgDDSMMAFTKGAPEMIASLC--------KPETV-PSNFQEVLNE----YTKQGFRVIALAY 459
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  677 RDFPSSPEPDWDNENDIL-NELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFL 755
Cdd:cd07542    460 KALESKTWLLQKLSREEVeSDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVARECGMISPSKKVI 539
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  756 CLEGKEfnrrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGI--IDSThteqrqvVAVTGDGTNDGPALKKADV 833
Cdd:cd07542    540 LIEAVK-------PEDDDSASLTWTLLLKGTVFARMSPDQKSELVEELqkLDYT-------VGMCGDGANDCGALKAADV 605
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  834 GFAMGIAGTDVakeASDIILTDDNFSSIVKAVMWGRNVYD---SISKFLqfqltvnVVAVIVAFTGACI--TQDSPLKAV 908
Cdd:cd07542    606 GISLSEAEASV---AAPFTSKVPDISCVPTVIKEGRAALVtsfSCFKYM-------ALYSLIQFISVLIlySINSNLGDF 675
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034633534  909 QMLWVNLIMDTFASLALATEPPTETLLLRKPYGRnkpLISRTMMKNILGHAVYQLALIFTLLFV 972
Cdd:cd07542    676 QFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LVSPPVLVSLLGQIVLILLFQVIGFLI 736
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
172-896 3.99e-27

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 118.15  E-value: 3.99e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  172 DWSKEKQFRGL-QSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRK 250
Cdd:cd07550     81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  251 SVDKdpMLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLLgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanas 330
Cdd:cd07550    160 REGD--LVFASTVVEEGQLVIRAERVGRETRAARIAELI----------------------------------------- 196
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  331 lvngkmqdgnvdasqskakqqdgaaamemqplksaeggdaddrKKASMHKKEKsvlQGKLTKLAVQIGKAGLVMSAITvi 410
Cdd:cd07550    197 -------------------------------------------EQSPSLKARI---QNYAERLADRLVPPTLGLAGLV-- 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  411 ilvlyftvdtfvvnkkpwlpectpvyvqyfvkFFIIG-----VTVLVV----AVPEGLPLAVTISLAYSVKKMMkdnnLV 481
Cdd:cd07550    229 --------------------------------YALTGdisraAAVLLVdfscGIRLSTPVAVLSALNHAARHGI----LV 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  482 RHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipdpssintktmellinaIAINSAYttkilpPEKEgal 561
Cdd:cd07550    273 KGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI---------------------------ITFDGRL------SEED--- 316
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  562 prqvgnktecgLLGFVLDLkqdyepvrsqmpEEKLYKVYTFNSVRKSMSTVIKLPDESFRMY--SKG-ASEIVLKKcckI 638
Cdd:cd07550    317 -----------LLYLAASA------------EEHFPHPVARAIVREAEERGIEHPEHEEVEYivGHGiASTVDGKR---I 370
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  639 LngAGEPRVFRPRDRD--EMVKKVIEPMACDGLRTICVAYrdfpsspepdwDNEndilneltCICVVGIEDPVRPEVPEA 716
Cdd:cd07550    371 R--VGSRHFMEEEEIIliPEVDELIEDLHAEGKSLLYVAI-----------DGR--------LIGVIGLSDPLRPEAAEV 429
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  717 IRKCQRAG-ITVRMVTGDNINTARAIAikcgiihpgedflclegkefnrrirnekgeiEQERIDkiwpklRVLARSSPTD 795
Cdd:cd07550    430 IARLRALGgKRIIMLTGDHEQRARALA-------------------------------EQLGID------RYHAEALPED 472
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  796 KHTLVKGIIDSTHTeqrqvVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSI 875
Cdd:cd07550    473 KAEIVEKLQAEGRT-----VAFVGDGINDSPALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALI 546
                          730       740
                   ....*....|....*....|.
gi 1034633534  876 SKFLQFQLTVNVVAVIVAFTG 896
Cdd:cd07550    547 KRNIALVVGPNTAVLAGGVFG 567
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
151-923 1.59e-26

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 116.36  E-value: 1.59e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  151 WIEGAAIllsVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKF-TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFI 229
Cdd:cd07545     59 WPEAAMV---VFLFAISEALEAYSMDRARRSIRSLMDIAPKTaLVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIV 135
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  230 QGNDLkIDESSLTGESDQVRKSVDKDpmLLSGTHVMEGSGRMLVTAVGVNSQTGIIFTLlgaggeeeekkdkkgvkkgdg 309
Cdd:cd07545    136 RGESS-VNQAAITGESLPVEKGVGDE--VFAGTLNGEGALEVRVTKPAEDSTIARIIHL--------------------- 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  310 lqlpaadgaaasnaadsanaslvngkmqdgnVDASQSkakqqdgaaamemqplksaeggdaddrkkasmhkkEKSVLQGK 389
Cdd:cd07545    192 -------------------------------VEEAQA-----------------------------------ERAPTQAF 205
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  390 LTKLAVQIGKAGLVMSAITVIILVLYFTVDTFvvnkkPWlpectpVYVqyfvkffiiGVTVLVVAVPEGLPLAVTISLAY 469
Cdd:cd07545    206 VDRFARYYTPVVMAIAALVAIVPPLFFGGAWF-----TW------IYR---------GLALLVVACPCALVISTPVSIVS 265
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  470 SVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVgdvhykeipdpssintktmellinaiainsayt 549
Cdd:cd07545    266 AIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVV--------------------------------- 312
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  550 tkilppekegalprqVGNKTECGLLGFVLDLKQdyepvRSQMPEEKLYkvytfnsVRKSMSTVIKLPD-ESFR-MYSKGA 627
Cdd:cd07545    313 ---------------LGGQTEKELLAIAAALEY-----RSEHPLASAI-------VKKAEQRGLTLSAvEEFTaLTGRGV 365
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  628 SEIVLKKCCKIlngaGEPRVFRPRDRDEMV--KKVIEPMACDGlRTICVayrdfpsspepdwdnendILNELTCICVVGI 705
Cdd:cd07545    366 RGVVNGTTYYI----GSPRLFEELNLSESPalEAKLDALQNQG-KTVMI------------------LGDGERILGVIAV 422
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  706 EDPVRPEVPEAIRKCQRAGI--TVrMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekGEIEQERIdkiwp 783
Cdd:cd07545    423 ADQVRPSSRNAIAALHQLGIkqTV-MLTGDNPQTAQAIAAQVGV-----------------------SDIRAELL----- 473
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  784 klrvlarssPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 863
Cdd:cd07545    474 ---------PQDKLDAIEAL-----QAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIALMGDDLRKLPF 539
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  864 AVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitqdsplkaVQMLWVNLIMDTFASL 923
Cdd:cd07545    540 AVRLSRKTLAIIKQNIAFALGIKLIALLLVIPG-----------WLTLWMAVFADMGASL 588
E1-E2_ATPase pfam00122
E1-E2 ATPase;
193-476 1.89e-26

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 107.27  E-value: 1.89e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKsvDKDPMLLSGTHVMEGSGRML 272
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  273 VTAVGVNSQTGIIFTLLgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqd 352
Cdd:pfam00122   85 VTATGEDTELGRIARLV--------------------------------------------------------------- 101
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  353 gaaamemqplksaeggdaddrkkaSMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVvnkkpwlpec 432
Cdd:pfam00122  102 ------------------------EEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRA---------- 147
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1034633534  433 tpvyvqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMK 476
Cdd:pfam00122  148 -----------LLRALAVLVAACPCALPLATPLALAVGARRLAK 180
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
442-845 4.39e-25

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 112.68  E-value: 4.39e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  442 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMtVVQAYVGDVHY 521
Cdd:cd02082    252 FIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQLKGQN 330
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  522 KEIPDPSSINTKTMELLINAIAINSAyTTKIlppekEGALprqVGNKTECGLLGFV-LDLKQDYE----PVRSQMPEEKL 596
Cdd:cd02082    331 QTFDPIQCQDPNNISIEHKLFAICHS-LTKI-----NGKL---LGDPLDVKMAEAStWDLDYDHEakqhYSKSGTKRFYI 401
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  597 YKVYTFNSVRKSMSTV---IKLPDESFRMYS--KGASEIVLKKCCKIlngageprvfrPRDRdemvKKVIEPMACDGLRT 671
Cdd:cd02082    402 IQVFQFHSALQRMSVVakeVDMITKDFKHYAfiKGAPEKIQSLFSHV-----------PSDE----KAQLSTLINEGYRV 466
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  672 ICVAYRDFPSSPEPDWDN--ENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIH 749
Cdd:cd02082    467 LALGYKELPQSEIDAFLDlsREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEIIN 546
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  750 PGEDFLCLEGkefnrrIRNEKGEIEQERIDKIwPKLRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALK 829
Cdd:cd02082    547 RKNPTIIIHL------LIPEIQKDNSTQWILI-IHTNVFARTAPEQKQTIIRLL-----KESDYIVCMCGDGANDCGALK 614
                          410
                   ....*....|....*.
gi 1034633534  830 KADVGFAMGIAGTDVA 845
Cdd:cd02082    615 EADVGISLAEADASFA 630
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
190-896 2.12e-24

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 109.72  E-value: 2.12e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  190 QKFTVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRKSvdkdpmllSGTHVMEGSg 269
Cdd:cd07544    110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKR--------PGDRVMSGA- 179
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  270 rmlvtavgvnsqtgiiftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslVNGkmqDGNVDASQSKAk 349
Cdd:cd07544    180 --------------------------------------------------------------VNG---DSALTMVATKL- 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  350 QQDGAAAMEMQPLKSAEGGDAddrkkasmhkkeksvlqgKLTKLAVQIGkaglvmsaitviilvLYFTVDTFVVNKKPWL 429
Cdd:cd07544    194 AADSQYAGIVRLVKEAQANPA------------------PFVRLADRYA---------------VPFTLLALAIAGVAWA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  430 PECTPVYVqyfvkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRM 509
Cdd:cd07544    241 VSGDPVRF----------AAVLVVATPCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQP 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  510 TVVQAyvgdvhykeIPDPssiNTKTMELL------------INAIAINSAYTTKILPPekegALPRQVGNKTECGLLGFV 577
Cdd:cd07544    311 KVVDV---------VPAP---GVDADEVLrlaasveqysshVLARAIVAAARERELQL----SAVTELTEVPGAGVTGTV 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  578 ldlkqdyepvrsqmpEEKLYKVYTFNSVRKSMSTviklpDESFRMYSKGASEIVLkkcckilngageprvfrprdrdemv 657
Cdd:cd07544    375 ---------------DGHEVKVGKLKFVLARGAW-----APDIRNRPLGGTAVYV------------------------- 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  658 kkviepmACDGlrTICVAYRdfpsspepdwdnendilneltcicvvgIEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNIN 736
Cdd:cd07544    410 -------SVDG--KYAGAIT---------------------------LRDEVRPEAKETLAHLRKAGVErLVMLTGDRRS 453
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  737 TARAIAIKCGIIHpgedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKgiidsTHTEQRQVVA 816
Cdd:cd07544    454 VAEYIASEVGIDE-------------------------------------VRAELLPEDKLAAVK-----EAPKAGPTIM 491
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  817 VtGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVA 893
Cdd:cd07544    492 V-GDGVNDAPALAAADVGIAMGARGSTAASEAADVVILVDDLDRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIA 567

                   ...
gi 1034633534  894 FTG 896
Cdd:cd07544    568 AFG 570
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
442-837 3.18e-22

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 103.62  E-value: 3.18e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  442 KFFIIGVTVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTTNRMtVV 512
Cdd:cd07543    260 KLFLECTLILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VV 329
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  513 QAYVGDVHYKE-IPDPSSINTKTmellINAIAinSAYTtkiLPPEKEGALprqVGNKTECGLLGFV---LDLKQDYEPVR 588
Cdd:cd07543    330 EGVAGLNDGKEvIPVSSIEPVET----ILVLA--SCHS---LVKLDDGKL---VGDPLEKATLEAVdwtLTKDEKVFPRS 397
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  589 SQMPEEKLYKVYTFNSVRKSMSTV--IKLP---DESFRMYSKGASEIV---LKKCckilngageprvfrPRDRDEMVKKv 660
Cdd:cd07543    398 KKTKGLKIIQRFHFSSALKRMSVVasYKDPgstDLKYIVAVKGAPETLksmLSDV--------------PADYDEVYKE- 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  661 iepMACDGLRTICVAYRDFPS---SPEPDWDNEnDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINT 737
Cdd:cd07543    463 ---YTRQGSRVLALGYKELGHltkQQARDYKRE-DVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLT 538
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  738 ARAIAIKCGIIhpgedflclegkeFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVkgiidSTHTEQRQVVAV 817
Cdd:cd07543    539 ACHVAKELGIV-------------DKPVLILILSEEGKSNEWKLIPHVKVFARVAPKQKEFII-----TTLKELGYVTLM 600
                          410       420
                   ....*....|....*....|
gi 1034633534  818 TGDGTNDGPALKKADVGFAM 837
Cdd:cd07543    601 CGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
384-892 4.64e-21

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 99.60  E-value: 4.64e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  384 SVLQGKLTKLAVQIGKAGLVMS-----------AITVIILVLYFTVDTFVVNKKPWLPEcTPVYVQY----FVKFFIIGV 448
Cdd:cd07536    220 VVYTGKETKLVMNTSNAKNKVGlldlelnrltkALFLALVVLSLVMVTLQGFWGPWYGE-KNWYIKKmdttSDNFGRNLL 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  449 TVLVV---AVPEGLPLAVTISLAYSVKKMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAY 515
Cdd:cd07536    299 RFLLLfsyIIPISLRVNLDMVKAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCH 378
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  516 VGDVHYKeipdpssintktmellinaiainsayttkilppekegalprqvGNKTECGLLgfvldlkqdyepvrsqmpeek 595
Cdd:cd07536    379 IGGVSYG-------------------------------------------GQVLSFCIL--------------------- 394
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  596 lyKVYTFNSVRKSMSTVIKLPDES-FRMYSKGASEIVLkkcckilngagePRVfRPRDRDEMVKKVIEPMACDGLRTICV 674
Cdd:cd07536    395 --QLLEFTSDRKRMSVIVRDESTGeITLYMKGADVAIS------------PIV-SKDSYMEQYNDWLEEECGEGLRTLCV 459
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  675 AYRDFPSSPEPDW------------DNE-------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNI 735
Cdd:cd07536    460 AKKALTENEYQEWesryteaslslhDRSlrvaevvESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQ 539
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  736 NTARAIAIKCGIIHP-------------GED-----FLCLEGKEFNRR------IRNEKGEI-----EQERID-KIWPKL 785
Cdd:cd07536    540 ETAICIAKSCHLVSRtqdihllrqdtsrGERaaitqHAHLELNAFRRKhdvalvIDGDSLEValkyyRHEFVElACQCPA 619
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  786 RVLARSSPTDKHTLVKgiIDSTHTEQRQVvaVTGDGTNDGPALKKADVGfaMGIAGTD--VAKEASDIILTddNFSSIVK 863
Cdd:cd07536    620 VICCRVSPTQKARIVT--LLKQHTGRRTL--AIGDGGNDVSMIQAADCG--VGISGKEgkQASLAADYSIT--QFRHLGR 691
                          570       580       590
                   ....*....|....*....|....*....|
gi 1034633534  864 AVM-WGRNVYDSISKFLQFQLTVNVVAVIV 892
Cdd:cd07536    692 LLLvHGRNSYNRSAALGQYVFYKGLIISTI 721
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
542-638 1.01e-19

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 84.96  E-value: 1.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  542 IAINSAyttkILPPEKEGALPRQVGNKTECGLLGFVLDLKQDYEPVRSQMPEEKlykVYTFNSVRKSMSTVIKLPDES-F 620
Cdd:pfam13246    1 ALCNSA----AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLPDDGkY 73
                           90
                   ....*....|....*...
gi 1034633534  621 RMYSKGASEIVLKKCCKI 638
Cdd:pfam13246   74 RLFVKGAPEIILDRCTTI 91
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
193-927 6.77e-19

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 92.08  E-value: 6.77e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  193 TVVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDlKIDESSLTGESDQVRKSvdkdpmllSGTHVMEGSgrml 272
Cdd:cd07546    102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKA--------AGDKVFAGS---- 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  273 vtavgvnsqtgiiftllgaggeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslVNGkmqdgnvdasqskakqqD 352
Cdd:cd07546    169 -----------------------------------------------------------INV-----------------D 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  353 GAAAMEmqpLKSAEGGDADDRKKASMHKKE--KSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTfvvnkKPWLP 430
Cdd:cd07546    173 GVLRIR---VTSAPGDNAIDRILHLIEEAEerRAPIERFIDRFSRWYTPAIMAVALLVIVVPPLLFGADW-----QTWIY 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  431 EctpvyvqyfvkffiiGVTVLVVAVPEGL----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTT 506
Cdd:cd07546    245 R---------------GLALLLIGCPCALvistPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTR 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  507 NRMTVVqayvgDVHYKEIPDPSsintktmELLINAIAINSAYT----TKILP-PEKEGALPRQVGNKTecGLLGFVLDLK 581
Cdd:cd07546    306 GKPVVT-----DVVPLTGISEA-------ELLALAAAVEMGSShplaQAIVArAQAAGLTIPPAEEAR--ALVGRGIEGQ 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  582 QDYEPVRsqmpeeklykvytfnsvrksmstviklpdesfrmyskgaseivlkkcckilngAGEPRVFRPRDRDEmVKKVI 661
Cdd:cd07546    372 VDGERVL-----------------------------------------------------IGAPKFAADRGTLE-VQGRI 397
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  662 EPMACDGlRTICVAYRdfpsspepdwdnENDILNeltcicVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 741
Cdd:cd07546    398 AALEQAG-KTVVVVLA------------NGRVLG------LIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAI 458
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  742 AIKCGIihpgeDFlclegkefnrrirneKGEIeqeridkiwpklrvlarsSPTDKhtlVKGIidsTHTEQRQVVAVTGDG 821
Cdd:cd07546    459 AAELGL-----DF---------------RAGL------------------LPEDK---VKAV---RELAQHGPVAMVGDG 494
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  822 TNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacITQ 901
Cdd:cd07546    495 INDAPAMKAASIGIAMG-SGTDVALETADAALTHNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG--ITG 571
                          730       740
                   ....*....|....*....|....*.
gi 1034633534  902 dsplkavqmLWVNLIMDTFASlALAT 927
Cdd:cd07546    572 ---------LWLAVLADTGAT-VLVT 587
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
702-869 2.58e-18

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 90.40  E-value: 2.58e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  702 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeridki 781
Cdd:cd02078    430 VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL-------------------------- 479
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  782 wpklrvlARSSPTDKHTLVKgiidsthTEQRQ--VVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFS 859
Cdd:cd02078    480 -------AEAKPEDKLELIR-------KEQAKgkLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAGNMVDLDSDPT 544
                          170
                   ....*....|
gi 1034633534  860 SIVKAVMWGR 869
Cdd:cd02078    545 KLIEVVEIGK 554
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
461-881 3.68e-18

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 90.16  E-value: 3.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  461 LAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYkeipdpsSINTKT 534
Cdd:cd07541    288 LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQNEMVFKKLHLGTVSY-------GGQNLN 360
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  535 MELLinaiainsayttkilppekegalprqvgnktecgllgfvldlkqdyepvrsqmpeeklyKVYTFNSVRKSMSTVIK 614
Cdd:cd07541    361 YEIL-----------------------------------------------------------QIFPFTSESKRMGIIVR 381
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  615 LP-DESFRMYSKGAseivlkkcckilngageprvfrprdrDEMVKKVIEP----------MACDGLRTICVAYRDFPSSP 683
Cdd:cd07541    382 EEkTGEITFYMKGA--------------------------DVVMSKIVQYndwleeecgnMAREGLRTLVVAKKKLSEEE 435
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  684 EPDWDNEND-------------------ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIK 744
Cdd:cd07541    436 YQAFEKRYNaaklsihdrdlkvaevvesLERELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKS 515
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  745 CGI------IH-------PGEDFLCLEgkeFNRRIRNEK------------GEIEQERIDKIWPKLRVLA-RSSPTDKHT 798
Cdd:cd07541    516 SKLvsrgqyIHvfrkvttREEAHLELN---NLRRKHDCAlvidgeslevclKYYEHEFIELACQLPAVVCcRCSPTQKAQ 592
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  799 LVKGIIDSThteQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTDdnFSSIVKAVMW-GRNVYDS 874
Cdd:cd07541    593 IVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ--FSHIGRLLLWhGRNSYKR 663

                   ....*..
gi 1034633534  875 ISKFLQF 881
Cdd:cd07541    664 SAKLAQF 670
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
705-869 1.93e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 84.21  E-value: 1.93e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  705 IEDPVRPEVPEAIRKCQRAGIT-VRMVTGDNINTARAIAIKCGIihpgedflclegkefnrrirnekgeieqeriDKIWP 783
Cdd:cd07548    426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGI-------------------------------DEVYA 474
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  784 KLrvlarsSPTDKHTLVKGIIDsthtEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVK 863
Cdd:cd07548    475 EL------LPEDKVEKVEELKA----ESKGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                   ....*.
gi 1034633534  864 AVMWGR 869
Cdd:cd07548    545 AIKIAR 550
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
702-897 1.70e-14

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 78.38  E-value: 1.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  702 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgEDFLclegkefnrrirnekgeieqeridki 781
Cdd:TIGR01497  440 VIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI-------------------------- 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  782 wpklrvlARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 861
Cdd:TIGR01497  490 -------AEATPEDKIALIR-----QEQAEGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKL 556
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1034633534  862 VKAVMWGRNVYDSISKFLQFQLTVNVV---AVI-VAFTGA 897
Cdd:TIGR01497  557 IEVVHIGKQLLITRGALTTFSIANDVAkyfAIIpAIFAAA 596
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
700-854 5.34e-14

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 76.96  E-value: 5.34e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  700 ICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIihpgeDFlclegkefnrrirnekgeieqerid 779
Cdd:PRK11033   560 LGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-----DF------------------------- 609
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034633534  780 kiwpklrvlaRSS--PTDKhtlVKGIidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 854
Cdd:PRK11033   610 ----------RAGllPEDK---VKAV---TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
copA PRK10671
copper-exporting P-type ATPase CopA;
702-865 1.08e-12

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 72.47  E-value: 1.08e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  702 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridki 781
Cdd:PRK10671   644 LLAIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGID--------------------------------- 690
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  782 wpklRVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 861
Cdd:PRK10671   691 ----EVIAGVLPDGKAEAIKRL-----QSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGV 760

                   ....
gi 1034633534  862 VKAV 865
Cdd:PRK10671   761 ADAL 764
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1126-1168 5.54e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 61.27  E-value: 5.54e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034633534 1126 GQILWFRGLNRIQTQIEVVNTFKSGA--SFQGALRRQS--SVTSQSQ 1168
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSLreGIQKPYLRNSihSFMSHPE 47
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
194-907 8.32e-12

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 69.31  E-value: 8.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  194 VVRAGQVVQIPVAEIVVGDIAQVKYGDLLPADGLFIQGNDLkIDESSLTGESDQVRksVDKDPMLLSGTHVMEGSGRMLV 273
Cdd:cd02092    131 LQADGSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPVT--VAPGDLVQAGAMNLSGPLRLRA 207
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  274 TAVGVNsqtgiifTLLGAGgeeeekkdkkgvkkgdglqlpaadgaaasnaadsanaslvngkmqdgnvdasqskakqqdg 353
Cdd:cd02092    208 TAAGDD-------TLLAEI------------------------------------------------------------- 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  354 AAAMEMqplksAEGGDAddrkkasmhkkeksvlqgKLTKLAVQIgkAGLVMSAITVIILVlyftvdTFVVnkkpWLPECT 433
Cdd:cd02092    220 ARLMEA-----AEQGRS------------------RYVRLADRA--ARLYAPVVHLLALL------TFVG----WVAAGG 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  434 PVYVQyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ 513
Cdd:cd02092    265 DWRHA-----LLIAVAVLIITCPCALGLAVPAVQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVG 339
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  514 AyvgdvhykeipdpSSINTKTMELLiNAIAINSAYTTKILPPEKEGALPRQVGNKTE---CGLLGFVLDLkqdyePVRSQ 590
Cdd:cd02092    340 A-------------HAISADLLALA-AALAQASRHPLSRALAAAAGARPVELDDAREvpgRGVEGRIDGA-----RVRLG 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  591 MPEeklykvytFNSVRKSMSTviklpdesfrmyskgASEIVLKKcckilnGAGEPRVFRprdrdemvkkviepmacdglr 670
Cdd:cd02092    401 RPA--------WLGASAGVST---------------ASELALSK------GGEEAARFP--------------------- 430
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  671 ticvayrdfpsspepdwdnendilneltcicvvgIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHp 750
Cdd:cd02092    431 ----------------------------------FEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED- 475
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  751 gedflclegkefnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIidsthTEQRQVVAVTGDGTNDGPALKK 830
Cdd:cd02092    476 ------------------------------------WRAGLTPAEKVARIEEL-----KAQGRRVLMVGDGLNDAPALAA 514
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034633534  831 ADVGFAMGIAgTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 907
Cdd:cd02092    515 AHVSMAPASA-VDASRSAADIVFLGDSLAPVPEAIEIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
PLN03190 PLN03190
aminophospholipid translocase; Provisional
444-741 3.91e-11

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 67.62  E-value: 3.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  444 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTTNRMT 510
Cdd:PLN03190   394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  511 VVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILP---------PEKEGA----------------LPRQV 565
Cdd:PLN03190   471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPqllelsksgKDTEEAkhvhdfflalaacntiVPIVV 550
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  566 GNKTE---------------------CGLLGFVLDLKQDYEPVRSQMPEEKLYKV---YTFNSVRKSMSTVIKLPDESFR 621
Cdd:PLN03190   551 DDTSDptvklmdyqgespdeqalvyaAAAYGFMLIERTSGHIVIDIHGERQRFNVlglHEFDSDRKRMSVILGCPDKTVK 630
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  622 MYSKGASEIVLKKCCKILNgagePRVFRPrdrdemVKKVIEPMACDGLRTICVAYRDFPSSPEPDWDNE----------- 690
Cdd:PLN03190   631 VFVKGADTSMFSVIDRSLN----MNVIRA------TEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFSfeaastaligr 700
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034633534  691 --------NDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 741
Cdd:PLN03190   701 aallrkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
448-907 1.15e-10

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 65.61  E-value: 1.15e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  448 VTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAyvgdvhykeipDP 527
Cdd:cd07553    273 TSVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFVMV-----------NP 341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  528 SSINTKtmellinaiAINSAYTTkilppekegalprqvgnktecgllgfvldLKQDYEPVrSQMPEEKLYKVytfNSVRK 607
Cdd:cd07553    342 EGIDRL---------ALRAISAI-----------------------------EAHSRHPI-SRAIREHLMAK---GLIKA 379
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  608 SMSTVIKLPDESFRMYSKGaSEIVLKKCCkilngageprvfrprdrdemvkkviepMACDGLRTICVAYRDfpsspepdw 687
Cdd:cd07553    380 GASELVEIVGKGVSGNSSG-SLWKLGSAP---------------------------DACGIQESGVVIARD--------- 422
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  688 dnendilneLTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAikcgiihpgeDFLCLEGKEfnrrir 767
Cdd:cd07553    423 ---------GRQLLDLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVG----------DSLGLDPRQ------ 477
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  768 nekgeieqeridkiwpklrVLARSSPTDKHTLVKgiidsthTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKE 847
Cdd:cd07553    478 -------------------LFGNLSPEEKLAWIE-------SHSPENTLMVGDGANDALALASAFVGIAVA-GEVGVSLE 530
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  848 ASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACitqdSPLKA 907
Cdd:cd07553    531 AADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLALSGWI----SPLVA 586
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
702-887 1.08e-09

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 62.80  E-value: 1.08e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  702 VVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIhpgedflclegkefnrrirnekgeieqeridki 781
Cdd:PRK14010   435 VIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------------------- 481
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  782 wpklRVLARSSPTDKHTLVKgiidsTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFSSI 861
Cdd:PRK14010   482 ----RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAANLIDLDSNPTKL 551
                          170       180
                   ....*....|....*....|....*.
gi 1034633534  862 VKAVMWGRNVYDSISKFLQFQLTVNV 887
Cdd:PRK14010   552 MEVVLIGKQLLMTRGSLTTFSIANDI 577
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
693-832 5.06e-08

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 54.51  E-value: 5.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  693 ILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFnrrirnekge 772
Cdd:pfam00702   83 VLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV---------- 152
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  773 ieqeridkiwpklrvlARSSPTDKHTLVKGIIDSTHteqrQVVAVtGDGTNDGPALKKAD 832
Cdd:pfam00702  153 ----------------GKPKPEIYLAALERLGVKPE----EVLMV-GDGVNDIPAAKAAG 191
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
50-112 6.11e-07

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 47.94  E-value: 6.11e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034633534   50 YGDTEAICRRLKTSPVEGLpgTAPDLEKRKQIFGQNFIPPKKPKTFLQLVWEALQDVTLIILE 112
Cdd:pfam00690    3 ALSVEEVLKKLGTDLEKGL--TEAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILL 63
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
711-857 3.85e-06

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 48.98  E-value: 3.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  711 PEVPEAIRKCQRAGITVRMVTGDNINTARAIAIKCGIIHPgedFLCLEGKEfnrrIRNEKGE------IEQERIDKIWPK 784
Cdd:COG0561     22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGAL----IYDPDGEvlyerpLDPEDVREILEL 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  785 LR-------VLARSSPT---------DKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEA 848
Cdd:COG0561     95 LRehglhlqVVVRSGPGfleilpkgvSKGSALKKLAERLGIPPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEVKAA 172

                   ....*....
gi 1034633534  849 SDIIlTDDN 857
Cdd:COG0561    173 ADYV-TGSN 180
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
766-864 5.96e-04

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 43.00  E-value: 5.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633534  766 IRNEKGEIEQ--ERIDKIWPKLRVLARSSP---------TDKHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVG 834
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 1034633534  835 FAMGIAgTDVAKEASDIILTDDNFSSIVKA 864
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
815-857 8.63e-04

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 42.64  E-value: 8.63e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034633534  815 VAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 857
Cdd:TIGR00099  207 VIAFGDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
HAD_HPP cd07517
phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate ...
796-867 8.84e-03

phosphatase, similar to Bacteroides thetaiotaomicron VPI-5482 BT4131 hexose phosphate phosphatase; belongs to the haloacid dehalogenase-like superfamily; Bacteroides thetaiotaomicron VPI-5482 BT4131 is a phosphatase with preference for hexose phosphates. In addition this family includes uncharacterized Bacillus subtilis YkrA, a putative phosphatase and uncharacterized Streptococcus pyogenes MGAS10394 a putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319819 [Multi-domain]  Cd Length: 213  Bit Score: 39.13  E-value: 8.84e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034633534  796 KHTLVKGIIDSTHTEQRQVVAVtGDGTNDGPALKKADVGFAMGIAGTDVaKEASDIIlTDDNFSS-IVKAVMW 867
Cdd:cd07517    142 KAKGIQKVIEHLGIKKEETMAF-GDGLNDIEMLEAVGIGIAMGNAHEEL-KEIADYV-TKDVDEDgILKALKH 211
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
810-857 9.70e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.12  E-value: 9.70e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034633534  810 EQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 857
Cdd:cd07516    198 SLEEVIAF-GDNENDLSMLEYAGLGVAMGNA-IDEVKEAADYV-TLTN 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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