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Conserved domains on  [gi|1034633686|ref|XP_016862033|]
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alpha-1,4-N-acetylglucosaminyltransferase isoform X1 [Homo sapiens]

Protein Classification

Gly_transf_sug and Gb3_synth domain-containing protein( domain architecture ID 10517332)

Gly_transf_sug and Gb3_synth domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 196-321 1.18e-59

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


:

Pssm-ID: 428017  Cd Length: 130  Bit Score: 187.84  E-value: 1.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686 196 GFLPHHPFLWECMENFVEHYNSAIWGNQGPELMTRMLRVWCKLEDFQEVSDLRCLNISFLHPQRFYPISYREWRRYYEVW 275
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1034633686 276 DTEPS---FNVSYALHLWNHMNQeGRAVIRGSNTLVENLYRKHCPRTYR 321
Cdd:pfam04572  81 DLEETmklTKDSYAVHLWNKLSK-GEPLKVGSNSLYARLARKHCPRTYA 128
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 64-182 4.29e-19

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


:

Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 80.84  E-value: 4.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686  64 PHLVSCSVESAAKIYPEWPVVFFMKGLTdstpmpsnstypafsflsaidnvflFPLDMKRLLEDTPlfsWYNQINasaER 143
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDLD-------------------------FALDINFLKSDTP---WFLEAY---SL 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034633686 144 NWLHI-SSDASRLAIIWKYGGIYMDTDVISIRPI----PEENFL 182
Cdd:pfam04488  50 LPLFIaKSDLLRYAILYKYGGIYLDTDVIPLKSLnsigAQERFL 93
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 196-321 1.18e-59

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 187.84  E-value: 1.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686 196 GFLPHHPFLWECMENFVEHYNSAIWGNQGPELMTRMLRVWCKLEDFQEVSDLRCLNISFLHPQRFYPISYREWRRYYEVW 275
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1034633686 276 DTEPS---FNVSYALHLWNHMNQeGRAVIRGSNTLVENLYRKHCPRTYR 321
Cdd:pfam04572  81 DLEETmklTKDSYAVHLWNKLSK-GEPLKVGSNSLYARLARKHCPRTYA 128
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 64-182 4.29e-19

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 80.84  E-value: 4.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686  64 PHLVSCSVESAAKIYPEWPVVFFMKGLTdstpmpsnstypafsflsaidnvflFPLDMKRLLEDTPlfsWYNQINasaER 143
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDLD-------------------------FALDINFLKSDTP---WFLEAY---SL 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034633686 144 NWLHI-SSDASRLAIIWKYGGIYMDTDVISIRPI----PEENFL 182
Cdd:pfam04488  50 LPLFIaKSDLLRYAILYKYGGIYLDTDVIPLKSLnsigAQERFL 93
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
129-209 4.99e-10

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 56.82  E-value: 4.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686 129 PLFSWYNQINASAERnwlhisSDASRLAIIWKYGGIYMDTDVISIRPIPEenFLAAQA---------SRYSSNGIFGFLP 199
Cdd:COG3774    55 EYLEAYYKLKKGAAR------ADLFRLLLLYKYGGIYLDIDVECLKPLDP--LLDGDDlflgyedppPGIISNGFIAAEP 126

                          90
                  ....*....|
gi 1034633686 200 HHPFLWECME 209
Cdd:COG3774   127 GHPFLKKALE 136
 
Name Accession Description Interval E-value
Gb3_synth pfam04572
Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of ...
 196-321 1.18e-59

Alpha 1,4-glycosyltransferase conserved region; The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilize UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region.


Pssm-ID: 428017  Cd Length: 130  Bit Score: 187.84  E-value: 1.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686 196 GFLPHHPFLWECMENFVEHYNSAIWGNQGPELMTRMLRVWCKLEDFQEVSDLRCLNISFLHPQRFYPISYREWRRYYEVW 275
Cdd:pfam04572   1 AFDKGHPFLELCLRDFVENYNGDEWGHNGPGLLTRVLKKFCNTSDLKAMERVRCRGFTVLPPEAFYPIPYPNWKRFFEPE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1034633686 276 DTEPS---FNVSYALHLWNHMNQeGRAVIRGSNTLVENLYRKHCPRTYR 321
Cdd:pfam04572  81 DLEETmklTKDSYAVHLWNKLSK-GEPLKVGSNSLYARLARKHCPRTYA 128
Gly_transf_sug pfam04488
Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short ...
 64-182 4.29e-19

Glycosyltransferase sugar-binding region containing DXD motif; The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases.


Pssm-ID: 398274 [Multi-domain]  Cd Length: 93  Bit Score: 80.84  E-value: 4.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686  64 PHLVSCSVESAAKIYPEWPVVFFMKGLTdstpmpsnstypafsflsaidnvflFPLDMKRLLEDTPlfsWYNQINasaER 143
Cdd:pfam04488   1 PERVMKAIESLIKLHPDYCYVVLSDDLD-------------------------FALDINFLKSDTP---WFLEAY---SL 49

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034633686 144 NWLHI-SSDASRLAIIWKYGGIYMDTDVISIRPI----PEENFL 182
Cdd:pfam04488  50 LPLFIaKSDLLRYAILYKYGGIYLDTDVIPLKSLnsigAQERFL 93
OCH1 COG3774
Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];
129-209 4.99e-10

Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442988 [Multi-domain]  Cd Length: 136  Bit Score: 56.82  E-value: 4.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633686 129 PLFSWYNQINASAERnwlhisSDASRLAIIWKYGGIYMDTDVISIRPIPEenFLAAQA---------SRYSSNGIFGFLP 199
Cdd:COG3774    55 EYLEAYYKLKKGAAR------ADLFRLLLLYKYGGIYLDIDVECLKPLDP--LLDGDDlflgyedppPGIISNGFIAAEP 126

                          90
                  ....*....|
gi 1034633686 200 HHPFLWECME 209
Cdd:COG3774   127 GHPFLKKALE 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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